-- dump date 20140619_102349 -- class Genbank::misc_feature -- table misc_feature_note -- id note 269799000001 conserved nucleotide sequence; Gmet_AN001 269799000002 conserved nucleotide sequence; Gmet_AN002 269799000003 palindrome; Gmet_AN003 269799000004 iteron pair; Gmet_AN004 269799000005 palindrome; Gmet_AN005 269799000006 conserved palindrome; Gmet_AN006 269799000007 two palindromes; Gmet_AN007 269799000008 iteron pair; Gmet_AN008 269799000009 iteron pair; Gmet_AN009 269799000010 iteron pair; Gmet_AN010 269799000011 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 269799000012 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799000013 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799000014 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799000015 conserved palindrome; Gmet_AN011 269799000016 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 269799000017 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 269799000018 addiction module autoregulatory site; Gmet_AN012 269799000019 conserved palindrome; Gmet_AN013 269799000020 conserved nucleotide sequence; Gmet_AN014 269799000021 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 269799000022 conserved nucleotide sequence; Gmet_AN015 269799000023 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 269799000024 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 269799000025 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 269799000026 conserved palindrome; Gmet_AN016 269799000027 conserved palindrome; Gmet_AN017 269799000028 conserved palindrome; Gmet_AN018 269799000029 conserved palindrome; Gmet_AN019 269799000030 six hairpins; Gmet_AN020 269799000031 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 269799000032 DnaA N-terminal domain; Region: DnaA_N; pfam11638 269799000033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799000034 Walker A motif; other site 269799000035 ATP binding site [chemical binding]; other site 269799000036 Walker B motif; other site 269799000037 arginine finger; other site 269799000038 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 269799000039 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 269799000040 DnaA box-binding interface [nucleotide binding]; other site 269799000041 DNA polymerase III subunit beta; Validated; Region: PRK05643 269799000042 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 269799000043 putative DNA binding surface [nucleotide binding]; other site 269799000044 dimer interface [polypeptide binding]; other site 269799000045 beta-clamp/clamp loader binding surface; other site 269799000046 beta-clamp/translesion DNA polymerase binding surface; other site 269799000047 recombination protein F; Reviewed; Region: recF; PRK00064 269799000048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799000049 Walker A/P-loop; other site 269799000050 ATP binding site [chemical binding]; other site 269799000051 Q-loop/lid; other site 269799000052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799000053 ABC transporter signature motif; other site 269799000054 Walker B; other site 269799000055 D-loop; other site 269799000056 H-loop/switch region; other site 269799000057 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 269799000058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000059 Mg2+ binding site [ion binding]; other site 269799000060 G-X-G motif; other site 269799000061 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 269799000062 anchoring element; other site 269799000063 dimer interface [polypeptide binding]; other site 269799000064 ATP binding site [chemical binding]; other site 269799000065 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 269799000066 active site 269799000067 putative metal-binding site [ion binding]; other site 269799000068 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 269799000069 DNA gyrase subunit A; Validated; Region: PRK05560 269799000070 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 269799000071 CAP-like domain; other site 269799000072 active site 269799000073 primary dimer interface [polypeptide binding]; other site 269799000074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269799000075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269799000076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269799000077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269799000078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269799000079 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269799000080 'integration host factor binding site, putative; Gmet_I101A' 269799000081 'integration host factor binding site, putative; Gmet_I101B' 269799000082 Homeodomain-like domain; Region: HTH_23; pfam13384 269799000083 Winged helix-turn helix; Region: HTH_29; pfam13551 269799000084 Integrase core domain; Region: rve; pfam00665 269799000085 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 269799000086 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 269799000087 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 269799000088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 269799000089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799000090 dimerization interface [polypeptide binding]; other site 269799000091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799000092 putative active site [active] 269799000093 heme pocket [chemical binding]; other site 269799000094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799000095 dimer interface [polypeptide binding]; other site 269799000096 phosphorylation site [posttranslational modification] 269799000097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000098 ATP binding site [chemical binding]; other site 269799000099 Mg2+ binding site [ion binding]; other site 269799000100 G-X-G motif; other site 269799000101 Response regulator receiver domain; Region: Response_reg; pfam00072 269799000102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799000103 active site 269799000104 phosphorylation site [posttranslational modification] 269799000105 intermolecular recognition site; other site 269799000106 dimerization interface [polypeptide binding]; other site 269799000107 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269799000108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799000109 putative active site [active] 269799000110 heme pocket [chemical binding]; other site 269799000111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799000112 dimer interface [polypeptide binding]; other site 269799000113 phosphorylation site [posttranslational modification] 269799000114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000115 ATP binding site [chemical binding]; other site 269799000116 Mg2+ binding site [ion binding]; other site 269799000117 G-X-G motif; other site 269799000118 PAS domain S-box; Region: sensory_box; TIGR00229 269799000119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799000120 putative active site [active] 269799000121 heme pocket [chemical binding]; other site 269799000122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799000123 dimer interface [polypeptide binding]; other site 269799000124 phosphorylation site [posttranslational modification] 269799000125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000126 ATP binding site [chemical binding]; other site 269799000127 Mg2+ binding site [ion binding]; other site 269799000128 G-X-G motif; other site 269799000129 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799000130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799000131 active site 269799000132 phosphorylation site [posttranslational modification] 269799000133 intermolecular recognition site; other site 269799000134 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269799000135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799000136 dimer interface [polypeptide binding]; other site 269799000137 phosphorylation site [posttranslational modification] 269799000138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000139 ATP binding site [chemical binding]; other site 269799000140 Mg2+ binding site [ion binding]; other site 269799000141 G-X-G motif; other site 269799000142 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269799000143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799000144 Walker A/P-loop; other site 269799000145 ATP binding site [chemical binding]; other site 269799000146 Q-loop/lid; other site 269799000147 ABC transporter signature motif; other site 269799000148 Walker B; other site 269799000149 D-loop; other site 269799000150 H-loop/switch region; other site 269799000151 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 269799000152 ABC-2 type transporter; Region: ABC2_membrane; cl17235 269799000153 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269799000154 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 269799000155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799000156 FeS/SAM binding site; other site 269799000157 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 269799000158 conserved nucleotide sequence; Gmet_R1001 269799000159 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 269799000160 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 269799000161 substrate binding site [chemical binding]; other site 269799000162 active site 269799000163 SlyX; Region: SlyX; pfam04102 269799000164 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 269799000165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799000166 dimerization interface [polypeptide binding]; other site 269799000167 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 269799000168 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799000169 Zn2+ binding site [ion binding]; other site 269799000170 Mg2+ binding site [ion binding]; other site 269799000171 Ferrochelatase; Region: Ferrochelatase; pfam00762 269799000172 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 269799000173 C-terminal domain interface [polypeptide binding]; other site 269799000174 active site 269799000175 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 269799000176 active site 269799000177 N-terminal domain interface [polypeptide binding]; other site 269799000178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799000179 Walker A motif; other site 269799000180 ATP binding site [chemical binding]; other site 269799000181 Walker B motif; other site 269799000182 arginine finger; other site 269799000183 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 269799000184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799000185 dimerization interface [polypeptide binding]; other site 269799000186 PAS domain S-box; Region: sensory_box; TIGR00229 269799000187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799000188 putative active site [active] 269799000189 heme pocket [chemical binding]; other site 269799000190 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 269799000191 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 269799000192 Protein of unknown function (DUF507); Region: DUF507; cl01112 269799000193 conserved nucleotide sequence; Gmet_R0060 269799000194 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 269799000195 oligomerisation interface [polypeptide binding]; other site 269799000196 mobile loop; other site 269799000197 roof hairpin; other site 269799000198 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 269799000199 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 269799000200 ring oligomerisation interface [polypeptide binding]; other site 269799000201 ATP/Mg binding site [chemical binding]; other site 269799000202 stacking interactions; other site 269799000203 hinge regions; other site 269799000204 PrkA AAA domain; Region: AAA_PrkA; smart00763 269799000205 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 269799000206 conserved nucleotide sequence; Gmet_R1002 269799000207 hypothetical protein; Provisional; Region: PRK05325 269799000208 SpoVR like protein; Region: SpoVR; pfam04293 269799000209 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 269799000210 PrkA AAA domain; Region: AAA_PrkA; smart00763 269799000211 AAA domain; Region: AAA_17; pfam13207 269799000212 phosphodiesterase YaeI; Provisional; Region: PRK11340 269799000213 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 269799000214 putative active site [active] 269799000215 putative metal binding site [ion binding]; other site 269799000216 HDOD domain; Region: HDOD; pfam08668 269799000217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799000218 Zn2+ binding site [ion binding]; other site 269799000219 Mg2+ binding site [ion binding]; other site 269799000220 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 269799000221 K+ potassium transporter; Region: K_trans; pfam02705 269799000222 K+ potassium transporter; Region: K_trans; pfam02705 269799000223 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 269799000224 Peptidase family U32; Region: Peptidase_U32; pfam01136 269799000225 Collagenase; Region: DUF3656; pfam12392 269799000226 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 269799000227 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 269799000228 dimerization interface [polypeptide binding]; other site 269799000229 domain crossover interface; other site 269799000230 redox-dependent activation switch; other site 269799000231 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 269799000232 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799000233 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 269799000234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000235 ATP binding site [chemical binding]; other site 269799000236 Mg2+ binding site [ion binding]; other site 269799000237 G-X-G motif; other site 269799000238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269799000239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799000240 active site 269799000241 phosphorylation site [posttranslational modification] 269799000242 intermolecular recognition site; other site 269799000243 dimerization interface [polypeptide binding]; other site 269799000244 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799000245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799000246 metal binding site [ion binding]; metal-binding site 269799000247 active site 269799000248 I-site; other site 269799000249 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799000250 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799000251 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799000252 'integration host factor binding site, putative; Gmet_I102A' 269799000253 'integration host factor binding site, putative; Gmet_I102B' 269799000254 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799000255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799000256 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799000257 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 269799000258 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269799000259 RNA binding surface [nucleotide binding]; other site 269799000260 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 269799000261 active site 269799000262 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 269799000263 dimer interface [polypeptide binding]; other site 269799000264 ADP-ribose binding site [chemical binding]; other site 269799000265 active site 269799000266 nudix motif; other site 269799000267 metal binding site [ion binding]; metal-binding site 269799000268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799000269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799000270 metal binding site [ion binding]; metal-binding site 269799000271 active site 269799000272 I-site; other site 269799000273 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 269799000274 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 269799000275 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269799000276 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269799000277 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269799000278 'integration host factor binding site, putative; Gmet_I201A' 269799000279 'integration host factor binding site, putative; Gmet_I201B' 269799000280 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 269799000281 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 269799000282 conserved nucleotide sequence; Gmet_R0061 269799000283 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799000284 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799000285 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 269799000286 Putative Fe-S cluster; Region: FeS; cl17515 269799000287 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 269799000288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799000289 Walker A motif; other site 269799000290 ATP binding site [chemical binding]; other site 269799000291 Walker B motif; other site 269799000292 arginine finger; other site 269799000293 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799000294 conserved nucleotide sequence; Gmet_R0062 269799000295 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 269799000296 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 269799000297 active site 269799000298 HIGH motif; other site 269799000299 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 269799000300 KMSKS motif; other site 269799000301 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 269799000302 tRNA binding surface [nucleotide binding]; other site 269799000303 anticodon binding site; other site 269799000304 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 269799000305 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269799000306 active site 269799000307 HIGH motif; other site 269799000308 nucleotide binding site [chemical binding]; other site 269799000309 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 269799000310 KMSKS motif; other site 269799000311 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 269799000312 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 269799000313 homotrimer interaction site [polypeptide binding]; other site 269799000314 zinc binding site [ion binding]; other site 269799000315 CDP-binding sites; other site 269799000316 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 269799000317 substrate binding site; other site 269799000318 dimer interface; other site 269799000319 selenocysteine synthase; Provisional; Region: PRK04311 269799000320 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 269799000321 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 269799000322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799000323 catalytic residue [active] 269799000324 Transcriptional regulators [Transcription]; Region: GntR; COG1802 269799000325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269799000326 DNA-binding site [nucleotide binding]; DNA binding site 269799000327 FCD domain; Region: FCD; pfam07729 269799000328 conserved nucleotide sequence; Gmet_R0063 269799000329 Ion channel; Region: Ion_trans_2; pfam07885 269799000330 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 269799000331 TrkA-N domain; Region: TrkA_N; pfam02254 269799000332 TrkA-C domain; Region: TrkA_C; pfam02080 269799000333 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 269799000334 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 269799000335 Metal-binding active site; metal-binding site 269799000336 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 269799000337 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 269799000338 putative active site [active] 269799000339 catalytic site [active] 269799000340 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 269799000341 putative active site [active] 269799000342 catalytic site [active] 269799000343 NusB family; Region: NusB; pfam01029 269799000344 16S rRNA methyltransferase B; Provisional; Region: PRK14902 269799000345 putative RNA binding site [nucleotide binding]; other site 269799000346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799000347 S-adenosylmethionine binding site [chemical binding]; other site 269799000348 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 269799000349 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 269799000350 substrate binding site [chemical binding]; other site 269799000351 hexamer interface [polypeptide binding]; other site 269799000352 metal binding site [ion binding]; metal-binding site 269799000353 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 269799000354 putative active site [active] 269799000355 putative CoA binding site [chemical binding]; other site 269799000356 nudix motif; other site 269799000357 metal binding site [ion binding]; metal-binding site 269799000358 Response regulator receiver domain; Region: Response_reg; pfam00072 269799000359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799000360 active site 269799000361 phosphorylation site [posttranslational modification] 269799000362 intermolecular recognition site; other site 269799000363 dimerization interface [polypeptide binding]; other site 269799000364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799000365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799000366 metal binding site [ion binding]; metal-binding site 269799000367 active site 269799000368 I-site; other site 269799000369 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 269799000370 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 269799000371 minor groove reading motif; other site 269799000372 helix-hairpin-helix signature motif; other site 269799000373 substrate binding pocket [chemical binding]; other site 269799000374 active site 269799000375 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 269799000376 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269799000377 metal binding triad; other site 269799000378 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 269799000379 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269799000380 metal binding triad; other site 269799000381 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 269799000382 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 269799000383 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 269799000384 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 269799000385 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 269799000386 GatB domain; Region: GatB_Yqey; smart00845 269799000387 BRO family, N-terminal domain; Region: Bro-N; pfam02498 269799000388 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 269799000389 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 269799000390 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 269799000391 conserved nucleotide sequence; Gmet_P0076 269799000392 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269799000393 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799000394 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 269799000395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799000396 dimer interface [polypeptide binding]; other site 269799000397 phosphorylation site [posttranslational modification] 269799000398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000399 ATP binding site [chemical binding]; other site 269799000400 Mg2+ binding site [ion binding]; other site 269799000401 G-X-G motif; other site 269799000402 Response regulator receiver domain; Region: Response_reg; pfam00072 269799000403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799000404 active site 269799000405 phosphorylation site [posttranslational modification] 269799000406 intermolecular recognition site; other site 269799000407 dimerization interface [polypeptide binding]; other site 269799000408 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 269799000409 PLD-like domain; Region: PLDc_2; pfam13091 269799000410 putative active site [active] 269799000411 catalytic site [active] 269799000412 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 269799000413 PLD-like domain; Region: PLDc_2; pfam13091 269799000414 putative active site [active] 269799000415 catalytic site [active] 269799000416 cyclase homology domain; Region: CHD; cd07302 269799000417 nucleotidyl binding site; other site 269799000418 metal binding site [ion binding]; metal-binding site 269799000419 dimer interface [polypeptide binding]; other site 269799000420 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799000421 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799000422 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 269799000423 nucleotidyl binding site; other site 269799000424 metal binding site [ion binding]; metal-binding site 269799000425 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 269799000426 conserved nucleotide sequence; Gmet_R2001 269799000427 SPFH domain / Band 7 family; Region: Band_7; pfam01145 269799000428 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 269799000429 conserved nucleotide sequence; Gmet_P0084 269799000430 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 269799000431 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 269799000432 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 269799000433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799000434 putative substrate translocation pore; other site 269799000435 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 269799000436 putative acyl-acceptor binding pocket; other site 269799000437 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 269799000438 acyl-activating enzyme (AAE) consensus motif; other site 269799000439 putative AMP binding site [chemical binding]; other site 269799000440 Amidohydrolase; Region: Amidohydro_2; pfam04909 269799000441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799000442 Walker B motif; other site 269799000443 arginine finger; other site 269799000444 conserved nucleotide sequence; Gmet_R1003 269799000445 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 269799000446 Part of AAA domain; Region: AAA_19; pfam13245 269799000447 Family description; Region: UvrD_C_2; pfam13538 269799000448 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 269799000449 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 269799000450 DNA binding site [nucleotide binding] 269799000451 active site 269799000452 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 269799000453 putative acyl-acceptor binding pocket; other site 269799000454 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269799000455 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269799000456 ligand binding site [chemical binding]; other site 269799000457 flexible hinge region; other site 269799000458 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 269799000459 putative switch regulator; other site 269799000460 non-specific DNA interactions [nucleotide binding]; other site 269799000461 DNA binding site [nucleotide binding] 269799000462 sequence specific DNA binding site [nucleotide binding]; other site 269799000463 putative cAMP binding site [chemical binding]; other site 269799000464 Homeodomain-like domain; Region: HTH_23; pfam13384 269799000465 Winged helix-turn helix; Region: HTH_29; pfam13551 269799000466 Integrase core domain; Region: rve; pfam00665 269799000467 'integration host factor binding site, putative; Gmet_I103A' 269799000468 'integration host factor binding site, putative; Gmet_I103B' 269799000469 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799000470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799000471 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799000472 SMUG: single-strand-selective monofunctional uracil-DNA glycosylase; Region: UDG_F3_SMUG; cd10029 269799000473 active site 269799000474 substrate specificity residue; other site 269799000475 DNA binding site [nucleotide binding] 269799000476 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 269799000477 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 269799000478 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 269799000479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269799000480 RNA binding surface [nucleotide binding]; other site 269799000481 elongation factor P; Provisional; Region: PRK14578 269799000482 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 269799000483 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 269799000484 RNA binding site [nucleotide binding]; other site 269799000485 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 269799000486 RNA binding site [nucleotide binding]; other site 269799000487 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 269799000488 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 269799000489 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 269799000490 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799000491 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 269799000492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799000493 FeS/SAM binding site; other site 269799000494 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14355 269799000495 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 269799000496 Substrate binding site; other site 269799000497 Mg++ binding site; other site 269799000498 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 269799000499 active site 269799000500 substrate binding site [chemical binding]; other site 269799000501 CoA binding site [chemical binding]; other site 269799000502 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 269799000503 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 269799000504 glutaminase active site [active] 269799000505 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 269799000506 dimer interface [polypeptide binding]; other site 269799000507 active site 269799000508 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 269799000509 dimer interface [polypeptide binding]; other site 269799000510 active site 269799000511 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 269799000512 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 269799000513 NAD binding site [chemical binding]; other site 269799000514 ligand binding site [chemical binding]; other site 269799000515 catalytic site [active] 269799000516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 269799000517 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 269799000518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799000519 Walker A motif; other site 269799000520 ATP binding site [chemical binding]; other site 269799000521 Walker B motif; other site 269799000522 arginine finger; other site 269799000523 Peptidase family M48; Region: Peptidase_M48; pfam01435 269799000524 OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336 269799000525 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269799000526 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269799000527 HSP70 interaction site [polypeptide binding]; other site 269799000528 PilZ domain; Region: PilZ; pfam07238 269799000529 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 269799000530 active site 269799000531 nucleophile elbow; other site 269799000532 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 269799000533 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 269799000534 dimerization interface [polypeptide binding]; other site 269799000535 ATP binding site [chemical binding]; other site 269799000536 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 269799000537 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 269799000538 HupF/HypC family; Region: HupF_HypC; pfam01455 269799000539 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 269799000540 Acylphosphatase; Region: Acylphosphatase; pfam00708 269799000541 HypF finger; Region: zf-HYPF; pfam07503 269799000542 HypF finger; Region: zf-HYPF; pfam07503 269799000543 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 269799000544 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799000545 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 269799000546 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 269799000547 domain interfaces; other site 269799000548 active site 269799000549 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 269799000550 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 269799000551 active site 269799000552 FMN binding site [chemical binding]; other site 269799000553 substrate binding site [chemical binding]; other site 269799000554 putative catalytic residue [active] 269799000555 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 269799000556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799000557 FeS/SAM binding site; other site 269799000558 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 269799000559 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 269799000560 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 269799000561 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 269799000562 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 269799000563 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 269799000564 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 269799000565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799000566 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 269799000567 non-specific DNA binding site [nucleotide binding]; other site 269799000568 salt bridge; other site 269799000569 sequence-specific DNA binding site [nucleotide binding]; other site 269799000570 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 269799000571 Catalytic site [active] 269799000572 'integration host factor binding site, putative; Gmet_I104A' 269799000573 'integration host factor binding site, putative; Gmet_I104B' 269799000574 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799000575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799000576 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799000577 polyphosphate kinase; Provisional; Region: PRK05443 269799000578 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 269799000579 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 269799000580 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 269799000581 putative domain interface [polypeptide binding]; other site 269799000582 putative active site [active] 269799000583 catalytic site [active] 269799000584 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 269799000585 putative domain interface [polypeptide binding]; other site 269799000586 putative active site [active] 269799000587 catalytic site [active] 269799000588 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 269799000589 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 269799000590 Cl binding site [ion binding]; other site 269799000591 oligomer interface [polypeptide binding]; other site 269799000592 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 269799000593 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 269799000594 active site 269799000595 substrate binding site [chemical binding]; other site 269799000596 metal binding site [ion binding]; metal-binding site 269799000597 Methyltransferase domain; Region: Methyltransf_31; pfam13847 269799000598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799000599 S-adenosylmethionine binding site [chemical binding]; other site 269799000600 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 269799000601 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 269799000602 substrate binding site [chemical binding]; other site 269799000603 Uncharacterized conserved protein [Function unknown]; Region: COG5316 269799000604 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 269799000605 ResB-like family; Region: ResB; pfam05140 269799000606 conserved nucleotide sequence; Gmet_R0064 269799000607 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 269799000608 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 269799000609 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 269799000610 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 269799000611 active site 269799000612 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 269799000613 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 269799000614 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 269799000615 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 269799000616 active site 269799000617 dimer interface [polypeptide binding]; other site 269799000618 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 269799000619 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 269799000620 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 269799000621 active site 269799000622 FMN binding site [chemical binding]; other site 269799000623 substrate binding site [chemical binding]; other site 269799000624 3Fe-4S cluster binding site [ion binding]; other site 269799000625 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 269799000626 domain_subunit interface; other site 269799000627 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 269799000628 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 269799000629 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 269799000630 propionate/acetate kinase; Provisional; Region: PRK12379 269799000631 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 269799000632 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269799000633 catalytic triad [active] 269799000634 thioredoxin 2; Provisional; Region: PRK10996 269799000635 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 269799000636 catalytic residues [active] 269799000637 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 269799000638 conserved nucleotide sequence; Gmet_R1004 269799000639 NADH dehydrogenase subunit B; Validated; Region: PRK06411 269799000640 trifunctional NADH dehydrogenase I subunit B/C/D; Provisional; Region: PRK13292 269799000641 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 269799000642 NADH dehydrogenase subunit D; Validated; Region: PRK06075 269799000643 NADH dehydrogenase subunit E; Validated; Region: PRK07539 269799000644 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 269799000645 putative dimer interface [polypeptide binding]; other site 269799000646 [2Fe-2S] cluster binding site [ion binding]; other site 269799000647 Cytochrome c; Region: Cytochrom_C; cl11414 269799000648 Uncharacterized conserved protein [Function unknown]; Region: COG3189 269799000649 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 269799000650 SLBB domain; Region: SLBB; pfam10531 269799000651 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 269799000652 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 269799000653 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799000654 catalytic loop [active] 269799000655 iron binding site [ion binding]; other site 269799000656 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 269799000657 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799000658 molybdopterin cofactor binding site; other site 269799000659 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799000660 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 269799000661 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 269799000662 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 269799000663 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799000664 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799000665 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 269799000666 4Fe-4S binding domain; Region: Fer4; pfam00037 269799000667 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 269799000668 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 269799000669 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 269799000670 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 269799000671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799000672 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 269799000673 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 269799000674 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 269799000675 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799000676 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 269799000677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799000678 hypothetical protein; Provisional; Region: PRK09272 269799000679 conserved nucleotide sequence; Gmet_R4001 269799000680 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 269799000681 mercuric reductase; Region: MerA; TIGR02053 269799000682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 269799000683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799000684 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 269799000685 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 269799000686 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 269799000687 TPP-binding site [chemical binding]; other site 269799000688 dimer interface [polypeptide binding]; other site 269799000689 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269799000690 PYR/PP interface [polypeptide binding]; other site 269799000691 dimer interface [polypeptide binding]; other site 269799000692 TPP binding site [chemical binding]; other site 269799000693 DTW domain; Region: DTW; cl01221 269799000694 'integration host factor binding site, putative; Gmet_I105A' 269799000695 'integration host factor binding site, putative; Gmet_I105B' 269799000696 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 269799000697 putative active site [active] 269799000698 putative catalytic site [active] 269799000699 Protein of unknown function, DUF393; Region: DUF393; pfam04134 269799000700 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 269799000701 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 269799000702 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 269799000703 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 269799000704 RNA binding site [nucleotide binding]; other site 269799000705 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 269799000706 dimer interface [polypeptide binding]; other site 269799000707 catalytic triad [active] 269799000708 peroxidatic and resolving cysteines [active] 269799000709 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 269799000710 Putative exonuclease, RdgC; Region: RdgC; cl01122 269799000711 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 269799000712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269799000713 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 269799000714 putative dimerization interface [polypeptide binding]; other site 269799000715 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 269799000716 ribonuclease Z; Provisional; Region: PRK02126 269799000717 'integration host factor binding site, putative; Gmet_I202A' 269799000718 'integration host factor binding site, putative; Gmet_I202B' 269799000719 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 269799000720 dimer interface [polypeptide binding]; other site 269799000721 active site 269799000722 Schiff base residues; other site 269799000723 Predicted membrane protein [Function unknown]; Region: COG2259 269799000724 PilZ domain; Region: PilZ; pfam07238 269799000725 conserved nucleotide sequence; Gmet_P0192 269799000726 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 269799000727 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 269799000728 G1 box; other site 269799000729 putative GEF interaction site [polypeptide binding]; other site 269799000730 GTP/Mg2+ binding site [chemical binding]; other site 269799000731 Switch I region; other site 269799000732 G2 box; other site 269799000733 G3 box; other site 269799000734 Switch II region; other site 269799000735 G4 box; other site 269799000736 G5 box; other site 269799000737 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 269799000738 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 269799000739 AIR carboxylase; Region: AIRC; smart01001 269799000740 hypothetical protein; Provisional; Region: PRK04194 269799000741 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 269799000742 tetramer interfaces [polypeptide binding]; other site 269799000743 binuclear metal-binding site [ion binding]; other site 269799000744 competence damage-inducible protein A; Provisional; Region: PRK00549 269799000745 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 269799000746 putative MPT binding site; other site 269799000747 Competence-damaged protein; Region: CinA; pfam02464 269799000748 PAS domain S-box; Region: sensory_box; TIGR00229 269799000749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799000750 putative active site [active] 269799000751 heme pocket [chemical binding]; other site 269799000752 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799000753 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799000754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799000755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799000756 dimer interface [polypeptide binding]; other site 269799000757 phosphorylation site [posttranslational modification] 269799000758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000759 ATP binding site [chemical binding]; other site 269799000760 Mg2+ binding site [ion binding]; other site 269799000761 G-X-G motif; other site 269799000762 recombinase A; Provisional; Region: recA; PRK09354 269799000763 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 269799000764 hexamer interface [polypeptide binding]; other site 269799000765 Walker A motif; other site 269799000766 ATP binding site [chemical binding]; other site 269799000767 Walker B motif; other site 269799000768 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 269799000769 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269799000770 Walker A motif; other site 269799000771 ATP binding site [chemical binding]; other site 269799000772 Walker B motif; other site 269799000773 recombination regulator RecX; Reviewed; Region: recX; PRK00117 269799000774 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 269799000775 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 269799000776 motif 1; other site 269799000777 active site 269799000778 motif 2; other site 269799000779 motif 3; other site 269799000780 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 269799000781 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 269799000782 linker region; other site 269799000783 DHHA1 domain; Region: DHHA1; pfam02272 269799000784 Response regulator receiver domain; Region: Response_reg; pfam00072 269799000785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799000786 active site 269799000787 phosphorylation site [posttranslational modification] 269799000788 intermolecular recognition site; other site 269799000789 dimerization interface [polypeptide binding]; other site 269799000790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799000791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799000792 dimer interface [polypeptide binding]; other site 269799000793 phosphorylation site [posttranslational modification] 269799000794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799000795 ATP binding site [chemical binding]; other site 269799000796 Mg2+ binding site [ion binding]; other site 269799000797 G-X-G motif; other site 269799000798 conserved nucleotide sequence; Gmet_P0203 269799000799 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 269799000800 feedback inhibition sensing region; other site 269799000801 homohexameric interface [polypeptide binding]; other site 269799000802 nucleotide binding site [chemical binding]; other site 269799000803 N-acetyl-L-glutamate binding site [chemical binding]; other site 269799000804 acetylornithine aminotransferase; Provisional; Region: PRK02627 269799000805 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269799000806 inhibitor-cofactor binding pocket; inhibition site 269799000807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799000808 catalytic residue [active] 269799000809 ornithine carbamoyltransferase; Provisional; Region: PRK00779 269799000810 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 269799000811 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 269799000812 argininosuccinate synthase; Provisional; Region: PRK13820 269799000813 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 269799000814 ANP binding site [chemical binding]; other site 269799000815 Substrate Binding Site II [chemical binding]; other site 269799000816 Substrate Binding Site I [chemical binding]; other site 269799000817 conserved nucleotide sequence; Gmet_P0207 269799000818 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 269799000819 nudix motif; other site 269799000820 argininosuccinate lyase; Provisional; Region: PRK00855 269799000821 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 269799000822 active sites [active] 269799000823 tetramer interface [polypeptide binding]; other site 269799000824 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 269799000825 conserved nucleotide sequence; Gmet_P0211 269799000826 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 269799000827 dihydrodipicolinate synthase; Region: dapA; TIGR00674 269799000828 dimer interface [polypeptide binding]; other site 269799000829 active site 269799000830 catalytic residue [active] 269799000831 dihydrodipicolinate reductase; Provisional; Region: PRK00048 269799000832 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 269799000833 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 269799000834 conserved nucleotide sequence; Gmet_R1005 269799000835 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 269799000836 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269799000837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799000838 homodimer interface [polypeptide binding]; other site 269799000839 catalytic residue [active] 269799000840 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 269799000841 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 269799000842 active site 269799000843 NTP binding site [chemical binding]; other site 269799000844 metal binding triad [ion binding]; metal-binding site 269799000845 antibiotic binding site [chemical binding]; other site 269799000846 HEPN domain; Region: HEPN; pfam05168 269799000847 conserved nucleotide sequence; Gmet_R0065 269799000848 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 269799000849 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 269799000850 active site 269799000851 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269799000852 substrate binding site [chemical binding]; other site 269799000853 catalytic residues [active] 269799000854 dimer interface [polypeptide binding]; other site 269799000855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 269799000856 methionine sulfoxide reductase B; Provisional; Region: PRK00222 269799000857 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 269799000858 methionine sulfoxide reductase A; Provisional; Region: PRK14054 269799000859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799000860 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 269799000861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269799000862 Coenzyme A binding pocket [chemical binding]; other site 269799000863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799000864 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269799000865 putative substrate translocation pore; other site 269799000866 conserved nucleotide sequence; Gmet_P0225 269799000867 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 269799000868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799000869 motif II; other site 269799000870 Protein of unknown function (DUF445); Region: DUF445; pfam04286 269799000871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799000872 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799000873 Predicted membrane protein [Function unknown]; Region: COG2259 269799000874 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 269799000875 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 269799000876 NAD(P) binding site [chemical binding]; other site 269799000877 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 269799000878 S1 domain; Region: S1_2; pfam13509 269799000879 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 269799000880 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 269799000881 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269799000882 DNA-binding site [nucleotide binding]; DNA binding site 269799000883 RNA-binding motif; other site 269799000884 conserved nucleotide sequence; Gmet_P0237 269799000885 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 269799000886 nucleoside/Zn binding site; other site 269799000887 dimer interface [polypeptide binding]; other site 269799000888 catalytic motif [active] 269799000889 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 269799000890 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 269799000891 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 269799000892 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 269799000893 Ligand binding site; other site 269799000894 Ligand binding site; other site 269799000895 Ligand binding site; other site 269799000896 Putative Catalytic site; other site 269799000897 DXD motif; other site 269799000898 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 269799000899 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 269799000900 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 269799000901 Radical SAM superfamily; Region: Radical_SAM; pfam04055 269799000902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 269799000903 serine/threonine protein kinase; Provisional; Region: PRK11768 269799000904 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 269799000905 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 269799000906 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 269799000907 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 269799000908 homodimer interface [polypeptide binding]; other site 269799000909 NADP binding site [chemical binding]; other site 269799000910 substrate binding site [chemical binding]; other site 269799000911 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 269799000912 Cu(I) binding site [ion binding]; other site 269799000913 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 269799000914 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 269799000915 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 269799000916 Subunit I/III interface [polypeptide binding]; other site 269799000917 conserved nucleotide sequence; Gmet_R1006 269799000918 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 269799000919 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 269799000920 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 269799000921 Cytochrome c; Region: Cytochrom_C; cl11414 269799000922 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 269799000923 UbiA prenyltransferase family; Region: UbiA; pfam01040 269799000924 Predicted membrane protein [Function unknown]; Region: COG2860 269799000925 UPF0126 domain; Region: UPF0126; pfam03458 269799000926 UPF0126 domain; Region: UPF0126; pfam03458 269799000927 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 269799000928 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 269799000929 cofactor binding site; other site 269799000930 DNA binding site [nucleotide binding] 269799000931 substrate interaction site [chemical binding]; other site 269799000932 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 269799000933 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799000934 acyl-activating enzyme (AAE) consensus motif; other site 269799000935 AMP binding site [chemical binding]; other site 269799000936 active site 269799000937 CoA binding site [chemical binding]; other site 269799000938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799000939 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269799000940 putative substrate translocation pore; other site 269799000941 conserved nucleotide sequence; Gmet_R0066 269799000942 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 269799000943 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 269799000944 FMN binding site [chemical binding]; other site 269799000945 active site 269799000946 catalytic residues [active] 269799000947 substrate binding site [chemical binding]; other site 269799000948 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 269799000949 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269799000950 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 269799000951 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269799000952 Walker A motif; other site 269799000953 ATP binding site [chemical binding]; other site 269799000954 Walker B motif; other site 269799000955 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 269799000956 hypothetical protein; Provisional; Region: PRK11239 269799000957 Protein of unknown function, DUF480; Region: DUF480; pfam04337 269799000958 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 269799000959 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 269799000960 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 269799000961 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 269799000962 dimer interface [polypeptide binding]; other site 269799000963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799000964 catalytic residue [active] 269799000965 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 269799000966 putative active site [active] 269799000967 putative CoA binding site [chemical binding]; other site 269799000968 nudix motif; other site 269799000969 metal binding site [ion binding]; metal-binding site 269799000970 PilZ domain; Region: PilZ; pfam07238 269799000971 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 269799000972 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 269799000973 active site 269799000974 methionine sulfoxide reductase A; Provisional; Region: PRK14054 269799000975 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 269799000976 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 269799000977 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 269799000978 tetramer interface [polypeptide binding]; other site 269799000979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799000980 catalytic residue [active] 269799000981 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 269799000982 murein hydrolase B; Provisional; Region: PRK10760; cl17906 269799000983 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 269799000984 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 269799000985 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 269799000986 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 269799000987 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 269799000988 Protein of unknown function (DUF770); Region: DUF770; pfam05591 269799000989 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 269799000990 Protein of unknown function (DUF877); Region: DUF877; pfam05943 269799000991 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 269799000992 Transposase domain (DUF772); Region: DUF772; pfam05598 269799000993 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799000994 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 269799000995 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 269799000996 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 269799000997 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 269799000998 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 269799000999 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 269799001000 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 269799001001 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 269799001002 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269799001003 PGAP1-like protein; Region: PGAP1; pfam07819 269799001004 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 269799001005 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 269799001006 Cytochrome c552; Region: Cytochrom_C552; pfam02335 269799001007 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 269799001008 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 269799001009 Cytochrome c552; Region: Cytochrom_C552; pfam02335 269799001010 4Fe-4S binding domain; Region: Fer4_5; pfam12801 269799001011 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799001012 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 269799001013 PAS domain S-box; Region: sensory_box; TIGR00229 269799001014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799001015 putative active site [active] 269799001016 heme pocket [chemical binding]; other site 269799001017 HPP family; Region: HPP; pfam04982 269799001018 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional; Region: PRK14489 269799001019 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 269799001020 GTP binding site; other site 269799001021 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 269799001022 Walker A motif; other site 269799001023 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 269799001024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799001025 FeS/SAM binding site; other site 269799001026 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 269799001027 'integration host factor binding site, putative; Gmet_I301A' 269799001028 'integration host factor binding site, putative; Gmet_I301B' 269799001029 MOSC domain; Region: MOSC; pfam03473 269799001030 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 269799001031 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 269799001032 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 269799001033 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 269799001034 succinyl-CoA synthetase, alpha subunit; Region: sucCoAalpha; TIGR01019 269799001035 CoA binding domain; Region: CoA_binding; cl17356 269799001036 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 269799001037 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 269799001038 citrylCoA binding site [chemical binding]; other site 269799001039 oxalacetate binding site [chemical binding]; other site 269799001040 coenzyme A binding site [chemical binding]; other site 269799001041 catalytic triad [active] 269799001042 conserved nucleotide sequence; Gmet_I401 269799001043 FOG: CBS domain [General function prediction only]; Region: COG0517 269799001044 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 269799001045 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 269799001046 L-aspartate oxidase; Provisional; Region: PRK06175 269799001047 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 269799001048 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 269799001049 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799001050 catalytic loop [active] 269799001051 iron binding site [ion binding]; other site 269799001052 conserved palindrome; Gmet_R5001 269799001053 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 269799001054 Cysteine-rich domain; Region: CCG; pfam02754 269799001055 Cysteine-rich domain; Region: CCG; pfam02754 269799001056 conserved nucleotide sequence; Gmet_R0067 269799001057 conserved nucleotide sequence; Gmet_R0068 269799001058 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 269799001059 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 269799001060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799001061 salt bridge; other site 269799001062 non-specific DNA binding site [nucleotide binding]; other site 269799001063 sequence-specific DNA binding site [nucleotide binding]; other site 269799001064 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 269799001065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799001066 non-specific DNA binding site [nucleotide binding]; other site 269799001067 salt bridge; other site 269799001068 sequence-specific DNA binding site [nucleotide binding]; other site 269799001069 transposase/IS protein; Provisional; Region: PRK09183 269799001070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799001071 Walker A motif; other site 269799001072 ATP binding site [chemical binding]; other site 269799001073 Walker B motif; other site 269799001074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 269799001075 Integrase core domain; Region: rve; pfam00665 269799001076 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799001077 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799001078 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799001079 conserved nucleotide sequence; Gmet_R4002 269799001080 tetrathionate reductase subunit B; Provisional; Region: PRK14993 269799001081 Predicted membrane protein [Function unknown]; Region: COG4881 269799001082 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 269799001083 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 269799001084 [4Fe-4S] binding site [ion binding]; other site 269799001085 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799001086 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799001087 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799001088 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 269799001089 molybdopterin cofactor binding site; other site 269799001090 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 269799001091 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799001092 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 269799001093 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 269799001094 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 269799001095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799001096 putative substrate translocation pore; other site 269799001097 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 269799001098 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799001099 heme-binding residues [chemical binding]; other site 269799001100 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 269799001101 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 269799001102 dimer interface [polypeptide binding]; other site 269799001103 putative functional site; other site 269799001104 putative MPT binding site; other site 269799001105 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 269799001106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799001107 FeS/SAM binding site; other site 269799001108 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 269799001109 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 269799001110 heme-binding site [chemical binding]; other site 269799001111 PAS domain; Region: PAS_10; pfam13596 269799001112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799001113 putative active site [active] 269799001114 heme pocket [chemical binding]; other site 269799001115 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 269799001116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799001117 Walker A motif; other site 269799001118 ATP binding site [chemical binding]; other site 269799001119 Walker B motif; other site 269799001120 arginine finger; other site 269799001121 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799001122 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269799001123 DNA-binding site [nucleotide binding]; DNA binding site 269799001124 RNA-binding motif; other site 269799001125 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 269799001126 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 269799001127 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269799001128 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799001129 ligand binding site [chemical binding]; other site 269799001130 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 269799001131 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 269799001132 Predicted membrane protein [Function unknown]; Region: COG1238 269799001133 conserved nucleotide sequence; Gmet_R0069 269799001134 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 269799001135 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 269799001136 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 269799001137 Zn binding site [ion binding]; other site 269799001138 Protein of unknown function, DUF399; Region: DUF399; pfam04187 269799001139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799001140 active site 269799001141 phosphorylation site [posttranslational modification] 269799001142 intermolecular recognition site; other site 269799001143 PAS domain; Region: PAS_8; pfam13188 269799001144 PAS domain; Region: PAS_9; pfam13426 269799001145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799001146 dimer interface [polypeptide binding]; other site 269799001147 phosphorylation site [posttranslational modification] 269799001148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799001149 ATP binding site [chemical binding]; other site 269799001150 Mg2+ binding site [ion binding]; other site 269799001151 G-X-G motif; other site 269799001152 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 269799001153 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269799001154 active site 269799001155 HIGH motif; other site 269799001156 nucleotide binding site [chemical binding]; other site 269799001157 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 269799001158 active site 269799001159 KMSKS motif; other site 269799001160 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 269799001161 tRNA binding surface [nucleotide binding]; other site 269799001162 anticodon binding site; other site 269799001163 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 269799001164 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 269799001165 lipoprotein signal peptidase; Provisional; Region: PRK14787 269799001166 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 269799001167 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 269799001168 Transglycosylase; Region: Transgly; pfam00912 269799001169 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 269799001170 conserved nucleotide sequence; Gmet_P0355 269799001171 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269799001172 IHF dimer interface [polypeptide binding]; other site 269799001173 IHF - DNA interface [nucleotide binding]; other site 269799001174 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 269799001175 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 269799001176 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 269799001177 conserved nucleotide sequence; Gmet_P0358 269799001178 transcriptional regulator SlyA; Provisional; Region: PRK03573 269799001179 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 269799001180 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 269799001181 short chain dehydrogenase; Validated; Region: PRK08264 269799001182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799001183 NAD(P) binding site [chemical binding]; other site 269799001184 active site 269799001185 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 269799001186 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 269799001187 dimer interface [polypeptide binding]; other site 269799001188 ssDNA binding site [nucleotide binding]; other site 269799001189 tetramer (dimer of dimers) interface [polypeptide binding]; other site 269799001190 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 269799001191 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 269799001192 putative acyl-acceptor binding pocket; other site 269799001193 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 269799001194 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269799001195 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 269799001196 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 269799001197 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 269799001198 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 269799001199 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799001200 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 269799001201 four heptanucleotide repeats; Gmet_H401 269799001202 Transcriptional regulator [Transcription]; Region: IclR; COG1414 269799001203 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 269799001204 Bacterial transcriptional regulator; Region: IclR; pfam01614 269799001205 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 269799001206 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 269799001207 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 269799001208 hydrogenase 4 subunit F; Validated; Region: PRK06458 269799001209 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799001210 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 269799001211 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 269799001212 hydrogenase 4 subunit B; Validated; Region: PRK06521 269799001213 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799001214 transcription termination factor Rho; Provisional; Region: rho; PRK09376 269799001215 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 269799001216 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 269799001217 RNA binding site [nucleotide binding]; other site 269799001218 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 269799001219 multimer interface [polypeptide binding]; other site 269799001220 Walker A motif; other site 269799001221 ATP binding site [chemical binding]; other site 269799001222 Walker B motif; other site 269799001223 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 269799001224 conserved nucleotide sequence; Gmet_P0378 269799001225 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 269799001226 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 269799001227 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 269799001228 peptide chain release factor 1; Validated; Region: prfA; PRK00591 269799001229 This domain is found in peptide chain release factors; Region: PCRF; smart00937 269799001230 RF-1 domain; Region: RF-1; pfam00472 269799001231 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 269799001232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799001233 S-adenosylmethionine binding site [chemical binding]; other site 269799001234 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 269799001235 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 269799001236 hinge; other site 269799001237 active site 269799001238 four heptanucleotide repeats; Gmet_H402 269799001239 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 269799001240 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 269799001241 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 269799001242 histidinol dehydrogenase; Region: hisD; TIGR00069 269799001243 NAD binding site [chemical binding]; other site 269799001244 dimerization interface [polypeptide binding]; other site 269799001245 product binding site; other site 269799001246 substrate binding site [chemical binding]; other site 269799001247 zinc binding site [ion binding]; other site 269799001248 catalytic residues [active] 269799001249 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 269799001250 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269799001251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799001252 homodimer interface [polypeptide binding]; other site 269799001253 catalytic residue [active] 269799001254 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 269799001255 putative active site pocket [active] 269799001256 4-fold oligomerization interface [polypeptide binding]; other site 269799001257 metal binding residues [ion binding]; metal-binding site 269799001258 3-fold/trimer interface [polypeptide binding]; other site 269799001259 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 269799001260 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 269799001261 putative active site [active] 269799001262 oxyanion strand; other site 269799001263 catalytic triad [active] 269799001264 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 269799001265 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 269799001266 catalytic residues [active] 269799001267 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 269799001268 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 269799001269 substrate binding site [chemical binding]; other site 269799001270 glutamase interaction surface [polypeptide binding]; other site 269799001271 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 269799001272 metal binding site [ion binding]; metal-binding site 269799001273 conserved nucleotide sequence; Gmet_P0391 269799001274 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 269799001275 Yqey-like protein; Region: YqeY; pfam09424 269799001276 Colicin V production protein; Region: Colicin_V; pfam02674 269799001277 DNA primase; Validated; Region: dnaG; PRK05667 269799001278 CHC2 zinc finger; Region: zf-CHC2; pfam01807 269799001279 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 269799001280 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 269799001281 active site 269799001282 metal binding site [ion binding]; metal-binding site 269799001283 interdomain interaction site; other site 269799001284 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 269799001285 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 269799001286 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 269799001287 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 269799001288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269799001289 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 269799001290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269799001291 DNA binding residues [nucleotide binding] 269799001292 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 269799001293 putative deacylase active site [active] 269799001294 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 269799001295 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 269799001296 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 269799001297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269799001298 Uncharacterized conserved protein [Function unknown]; Region: COG0327 269799001299 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 269799001300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 269799001301 Uncharacterized conserved protein [Function unknown]; Region: COG0327 269799001302 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 269799001303 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 269799001304 Putative zinc ribbon domain; Region: DUF164; pfam02591 269799001305 conserved nucleotide sequence; Gmet_P0403 269799001306 cell division protein MraZ; Reviewed; Region: PRK00326 269799001307 MraZ protein; Region: MraZ; pfam02381 269799001308 MraZ protein; Region: MraZ; pfam02381 269799001309 MraW methylase family; Region: Methyltransf_5; pfam01795 269799001310 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 269799001311 cell division protein FtsL; Region: ftsL_broad; TIGR02209 269799001312 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 269799001313 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 269799001314 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 269799001315 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 269799001316 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 269799001317 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 269799001318 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269799001319 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269799001320 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 269799001321 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 269799001322 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269799001323 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269799001324 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 269799001325 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 269799001326 Mg++ binding site [ion binding]; other site 269799001327 putative catalytic motif [active] 269799001328 putative substrate binding site [chemical binding]; other site 269799001329 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 269799001330 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 269799001331 NAD(P) binding pocket [chemical binding]; other site 269799001332 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269799001333 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269799001334 cell division protein FtsW; Region: ftsW; TIGR02614 269799001335 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 269799001336 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 269799001337 active site 269799001338 homodimer interface [polypeptide binding]; other site 269799001339 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 269799001340 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 269799001341 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 269799001342 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269799001343 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 269799001344 FAD binding domain; Region: FAD_binding_4; pfam01565 269799001345 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 269799001346 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 269799001347 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 269799001348 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269799001349 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 269799001350 Cell division protein FtsQ; Region: FtsQ; pfam03799 269799001351 four heptanucleotide repeats; Gmet_H403 269799001352 cell division protein FtsA; Region: ftsA; TIGR01174 269799001353 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 269799001354 nucleotide binding site [chemical binding]; other site 269799001355 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 269799001356 Cell division protein FtsA; Region: FtsA; pfam14450 269799001357 cell division protein FtsZ; Validated; Region: PRK09330 269799001358 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 269799001359 nucleotide binding site [chemical binding]; other site 269799001360 SulA interaction site; other site 269799001361 conserved nucleotide sequence; Gmet_P0418 269799001362 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 269799001363 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 269799001364 B12 binding site [chemical binding]; other site 269799001365 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 269799001366 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 269799001367 Active site cavity [active] 269799001368 catalytic acid [active] 269799001369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799001370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799001371 WHG domain; Region: WHG; pfam13305 269799001372 BON domain; Region: BON; pfam04972 269799001373 BON domain; Region: BON; pfam04972 269799001374 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 269799001375 classical (c) SDRs; Region: SDR_c; cd05233 269799001376 NAD(P) binding site [chemical binding]; other site 269799001377 active site 269799001378 Radical SAM superfamily; Region: Radical_SAM; pfam04055 269799001379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799001380 FeS/SAM binding site; other site 269799001381 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 269799001382 FHIPEP family; Region: FHIPEP; pfam00771 269799001383 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 269799001384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799001385 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799001386 Walker A/P-loop; other site 269799001387 ATP binding site [chemical binding]; other site 269799001388 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 269799001389 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799001390 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 269799001391 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 269799001392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269799001393 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 269799001394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269799001395 DNA binding residues [nucleotide binding] 269799001396 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 269799001397 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 269799001398 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 269799001399 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 269799001400 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269799001401 SAF-like; Region: SAF_2; pfam13144 269799001402 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 269799001403 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 269799001404 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 269799001405 Flagellar L-ring protein; Region: FlgH; pfam02107 269799001406 four heptanucleotide repeats; Gmet_H404 269799001407 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 269799001408 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 269799001409 four heptanucleotide repeats; Gmet_H405 269799001410 four heptanucleotide repeats; Gmet_H406 269799001411 Rod binding protein; Region: Rod-binding; pfam10135 269799001412 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 269799001413 FlgN protein; Region: FlgN; pfam05130 269799001414 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 269799001415 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 269799001416 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269799001417 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 269799001418 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 269799001419 Global regulator protein family; Region: CsrA; pfam02599 269799001420 flagellar assembly protein FliW; Provisional; Region: PRK13285 269799001421 flagellin; Provisional; Region: PRK12802 269799001422 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 269799001423 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 269799001424 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799001425 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799001426 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 269799001427 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 269799001428 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 269799001429 Flagellar protein FliS; Region: FliS; cl00654 269799001430 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 269799001431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799001432 binding surface 269799001433 TPR motif; other site 269799001434 N-terminal catalytic domain of alpha-galactosidase; glycoside hydrolase family 57 (GH57); Region: GH57N_PfGalA_like; cd10794 269799001435 putative active site [active] 269799001436 catalytic site [active] 269799001437 hypothetical protein; Provisional; Region: PRK07206 269799001438 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 269799001439 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 269799001440 classical (c) SDRs; Region: SDR_c; cd05233 269799001441 NAD(P) binding site [chemical binding]; other site 269799001442 active site 269799001443 Glucuronate isomerase; Region: UxaC; pfam02614 269799001444 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 269799001445 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799001446 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799001447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799001448 S-adenosylmethionine binding site [chemical binding]; other site 269799001449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 269799001450 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 269799001451 ligand binding site; other site 269799001452 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 269799001453 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269799001454 NeuB family; Region: NeuB; pfam03102 269799001455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 269799001456 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 269799001457 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 269799001458 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799001459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799001460 S-adenosylmethionine binding site [chemical binding]; other site 269799001461 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 269799001462 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 269799001463 inhibitor-cofactor binding pocket; inhibition site 269799001464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799001465 catalytic residue [active] 269799001466 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 269799001467 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 269799001468 NAD(P) binding site [chemical binding]; other site 269799001469 homodimer interface [polypeptide binding]; other site 269799001470 substrate binding site [chemical binding]; other site 269799001471 active site 269799001472 PilZ domain; Region: PilZ; pfam07238 269799001473 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 269799001474 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 269799001475 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799001476 ligand binding site [chemical binding]; other site 269799001477 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 269799001478 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 269799001479 Flagellar protein (FlbD); Region: FlbD; pfam06289 269799001480 FlaG protein; Region: FlaG; pfam03646 269799001481 HDOD domain; Region: HDOD; pfam08668 269799001482 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 269799001483 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 269799001484 G1 box; other site 269799001485 GTP/Mg2+ binding site [chemical binding]; other site 269799001486 Switch I region; other site 269799001487 G2 box; other site 269799001488 G3 box; other site 269799001489 Switch II region; other site 269799001490 G4 box; other site 269799001491 G5 box; other site 269799001492 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 269799001493 homotrimer interface [polypeptide binding]; other site 269799001494 Walker A motif; other site 269799001495 GTP binding site [chemical binding]; other site 269799001496 Walker B motif; other site 269799001497 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 269799001498 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 269799001499 putative dimer interface [polypeptide binding]; other site 269799001500 active site pocket [active] 269799001501 putative cataytic base [active] 269799001502 four heptanucleotide repeats; Gmet_H407 269799001503 cobalamin synthase; Reviewed; Region: cobS; PRK00235 269799001504 four heptanucleotide repeats; Gmet_H408 269799001505 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 269799001506 catalytic core [active] 269799001507 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 269799001508 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799001509 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 269799001510 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 269799001511 catalytic triad [active] 269799001512 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 269799001513 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 269799001514 'integration host factor binding site, putative; Gmet_I203A' 269799001515 'integration host factor binding site, putative; Gmet_I203B' 269799001516 cobalt transport protein CbiM; Validated; Region: PRK08319 269799001517 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 269799001518 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 269799001519 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 269799001520 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 269799001521 Walker A/P-loop; other site 269799001522 ATP binding site [chemical binding]; other site 269799001523 Q-loop/lid; other site 269799001524 ABC transporter signature motif; other site 269799001525 Walker B; other site 269799001526 D-loop; other site 269799001527 H-loop/switch region; other site 269799001528 conserved nucleotide sequence; Gmet_R6001 269799001529 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 269799001530 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 269799001531 putative active site [active] 269799001532 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 269799001533 Precorrin-8X methylmutase; Region: CbiC; pfam02570 269799001534 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 269799001535 four heptanucleotide repeats; Gmet_H409 269799001536 four heptanucleotide repeats; Gmet_H410 269799001537 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 269799001538 active site 269799001539 NTP binding site [chemical binding]; other site 269799001540 metal binding triad [ion binding]; metal-binding site 269799001541 antibiotic binding site [chemical binding]; other site 269799001542 Uncharacterized conserved protein [Function unknown]; Region: COG2361 269799001543 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 269799001544 active site 269799001545 putative homodimer interface [polypeptide binding]; other site 269799001546 SAM binding site [chemical binding]; other site 269799001547 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 269799001548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799001549 S-adenosylmethionine binding site [chemical binding]; other site 269799001550 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 269799001551 active site 269799001552 SAM binding site [chemical binding]; other site 269799001553 homodimer interface [polypeptide binding]; other site 269799001554 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 269799001555 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 269799001556 active site 269799001557 SAM binding site [chemical binding]; other site 269799001558 homodimer interface [polypeptide binding]; other site 269799001559 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 269799001560 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 269799001561 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 269799001562 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 269799001563 'integration host factor binding site, putative; Gmet_I302A' 269799001564 'integration host factor binding site, putative; Gmet_I302B' 269799001565 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 269799001566 active site 269799001567 SAM binding site [chemical binding]; other site 269799001568 homodimer interface [polypeptide binding]; other site 269799001569 cobyric acid synthase; Provisional; Region: PRK00784 269799001570 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 269799001571 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 269799001572 catalytic triad [active] 269799001573 four heptanucleotide repeats; Gmet_H411 269799001574 four heptanucleotide repeats; Gmet_H412 269799001575 four heptanucleotide repeats; Gmet_H413 269799001576 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 269799001577 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 269799001578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269799001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799001580 homodimer interface [polypeptide binding]; other site 269799001581 catalytic residue [active] 269799001582 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799001583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799001584 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799001585 'integration host factor binding site, putative; Gmet_I106A' 269799001586 'integration host factor binding site, putative; Gmet_I106B' 269799001587 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 269799001588 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 269799001589 trimer interface [polypeptide binding]; other site 269799001590 putative Zn binding site [ion binding]; other site 269799001591 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 269799001592 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 269799001593 metal binding site [ion binding]; metal-binding site 269799001594 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 269799001595 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 269799001596 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 269799001597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 269799001598 ABC-ATPase subunit interface; other site 269799001599 dimer interface [polypeptide binding]; other site 269799001600 putative PBP binding regions; other site 269799001601 nickel responsive regulator; Provisional; Region: PRK04460 269799001602 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 269799001603 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 269799001604 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 269799001605 catalytic center binding site [active] 269799001606 ATP binding site [chemical binding]; other site 269799001607 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 269799001608 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 269799001609 active site 269799001610 intersubunit interactions; other site 269799001611 catalytic residue [active] 269799001612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269799001613 Coenzyme A binding pocket [chemical binding]; other site 269799001614 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 269799001615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799001616 PAS domain; Region: PAS_9; pfam13426 269799001617 putative active site [active] 269799001618 heme pocket [chemical binding]; other site 269799001619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799001620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799001621 dimer interface [polypeptide binding]; other site 269799001622 phosphorylation site [posttranslational modification] 269799001623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799001624 ATP binding site [chemical binding]; other site 269799001625 Mg2+ binding site [ion binding]; other site 269799001626 G-X-G motif; other site 269799001627 Response regulator receiver domain; Region: Response_reg; pfam00072 269799001628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799001629 active site 269799001630 phosphorylation site [posttranslational modification] 269799001631 intermolecular recognition site; other site 269799001632 dimerization interface [polypeptide binding]; other site 269799001633 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 269799001634 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 269799001635 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 269799001636 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 269799001637 DRTGG domain; Region: DRTGG; pfam07085 269799001638 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 269799001639 DHH family; Region: DHH; pfam01368 269799001640 DHHA2 domain; Region: DHHA2; pfam02833 269799001641 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 269799001642 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 269799001643 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 269799001644 FAD binding site [chemical binding]; other site 269799001645 YtxH-like protein; Region: YtxH; cl02079 269799001646 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 269799001647 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269799001648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799001649 ligand binding site [chemical binding]; other site 269799001650 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 269799001651 molybdenum-pterin binding domain; Region: Mop; TIGR00638 269799001652 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 269799001653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 269799001654 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 269799001655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799001656 dimer interface [polypeptide binding]; other site 269799001657 conserved gate region; other site 269799001658 putative PBP binding loops; other site 269799001659 ABC-ATPase subunit interface; other site 269799001660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799001661 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 269799001662 Walker A/P-loop; other site 269799001663 ATP binding site [chemical binding]; other site 269799001664 Q-loop/lid; other site 269799001665 ABC transporter signature motif; other site 269799001666 Walker B; other site 269799001667 D-loop; other site 269799001668 H-loop/switch region; other site 269799001669 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 269799001670 Cation efflux family; Region: Cation_efflux; cl00316 269799001671 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 269799001672 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 269799001673 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 269799001674 catalytic residues [active] 269799001675 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 269799001676 Predicted permeases [General function prediction only]; Region: COG0701 269799001677 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 269799001678 arsenical-resistance protein; Region: acr3; TIGR00832 269799001679 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 269799001680 Low molecular weight phosphatase family; Region: LMWPc; cd00115 269799001681 active site 269799001682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269799001683 dimerization interface [polypeptide binding]; other site 269799001684 putative DNA binding site [nucleotide binding]; other site 269799001685 putative Zn2+ binding site [ion binding]; other site 269799001686 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 269799001687 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 269799001688 Walker A/P-loop; other site 269799001689 ATP binding site [chemical binding]; other site 269799001690 Q-loop/lid; other site 269799001691 ABC transporter signature motif; other site 269799001692 Walker B; other site 269799001693 D-loop; other site 269799001694 H-loop/switch region; other site 269799001695 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 269799001696 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 269799001697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799001698 dimer interface [polypeptide binding]; other site 269799001699 conserved gate region; other site 269799001700 putative PBP binding loops; other site 269799001701 ABC-ATPase subunit interface; other site 269799001702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799001703 putative PBP binding loops; other site 269799001704 dimer interface [polypeptide binding]; other site 269799001705 ABC-ATPase subunit interface; other site 269799001706 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 269799001707 active site 269799001708 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 269799001709 Sulfatase; Region: Sulfatase; pfam00884 269799001710 conserved nucleotide sequence; Gmet_P0526 269799001711 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 269799001712 HAMP domain; Region: HAMP; pfam00672 269799001713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799001714 dimer interface [polypeptide binding]; other site 269799001715 phosphorylation site [posttranslational modification] 269799001716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799001717 ATP binding site [chemical binding]; other site 269799001718 Mg2+ binding site [ion binding]; other site 269799001719 G-X-G motif; other site 269799001720 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 269799001721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799001722 active site 269799001723 phosphorylation site [posttranslational modification] 269799001724 intermolecular recognition site; other site 269799001725 dimerization interface [polypeptide binding]; other site 269799001726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269799001727 DNA binding site [nucleotide binding] 269799001728 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799001729 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799001730 dimerization interface [polypeptide binding]; other site 269799001731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799001732 dimer interface [polypeptide binding]; other site 269799001733 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 269799001734 putative CheW interface [polypeptide binding]; other site 269799001735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269799001736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269799001737 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 269799001738 dimerization interface [polypeptide binding]; other site 269799001739 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 269799001740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 269799001741 active site residue [active] 269799001742 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 269799001743 active site residue [active] 269799001744 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 269799001745 conserved nucleotide sequence; Gmet_P0535 269799001746 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 269799001747 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 269799001748 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 269799001749 iron-sulfur cluster [ion binding]; other site 269799001750 [2Fe-2S] cluster binding site [ion binding]; other site 269799001751 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 269799001752 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 269799001753 intrachain domain interface; other site 269799001754 heme bH binding site [chemical binding]; other site 269799001755 heme bL binding site [chemical binding]; other site 269799001756 interchain domain interface [polypeptide binding]; other site 269799001757 Qo binding site; other site 269799001758 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 269799001759 Cytochrome c; Region: Cytochrom_C; cl11414 269799001760 Predicted metallopeptidase [General function prediction only]; Region: COG4900 269799001761 four heptanucleotide repeats; Gmet_H414 269799001762 four heptanucleotide repeats; Gmet_H415 269799001763 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 269799001764 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 269799001765 glutamate racemase; Provisional; Region: PRK00865 269799001766 Sporulation and spore germination; Region: Germane; pfam10646 269799001767 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 269799001768 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 269799001769 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 269799001770 substrate binding pocket [chemical binding]; other site 269799001771 dimer interface [polypeptide binding]; other site 269799001772 inhibitor binding site; inhibition site 269799001773 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 269799001774 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 269799001775 B12 binding site [chemical binding]; other site 269799001776 cobalt ligand [ion binding]; other site 269799001777 transketolase; Reviewed; Region: PRK05899 269799001778 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 269799001779 TPP-binding site [chemical binding]; other site 269799001780 dimer interface [polypeptide binding]; other site 269799001781 conserved nucleotide sequence; Gmet_R1007 269799001782 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 269799001783 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269799001784 PYR/PP interface [polypeptide binding]; other site 269799001785 dimer interface [polypeptide binding]; other site 269799001786 TPP binding site [chemical binding]; other site 269799001787 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269799001788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799001789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799001790 dimerization interface [polypeptide binding]; other site 269799001791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799001792 dimer interface [polypeptide binding]; other site 269799001793 phosphorylation site [posttranslational modification] 269799001794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799001795 ATP binding site [chemical binding]; other site 269799001796 Mg2+ binding site [ion binding]; other site 269799001797 G-X-G motif; other site 269799001798 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799001799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799001800 active site 269799001801 phosphorylation site [posttranslational modification] 269799001802 intermolecular recognition site; other site 269799001803 dimerization interface [polypeptide binding]; other site 269799001804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799001805 Walker A motif; other site 269799001806 ATP binding site [chemical binding]; other site 269799001807 Walker B motif; other site 269799001808 arginine finger; other site 269799001809 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799001810 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 269799001811 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 269799001812 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 269799001813 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 269799001814 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799001815 Right handed beta helix region; Region: Beta_helix; pfam13229 269799001816 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 269799001817 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 269799001818 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 269799001819 ResB-like family; Region: ResB; pfam05140 269799001820 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 269799001821 Predicted permease; Region: DUF318; cl17795 269799001822 Cupin domain; Region: Cupin_2; pfam07883 269799001823 'integration host factor binding site, putative; Gmet_I204A' 269799001824 'integration host factor binding site, putative; Gmet_I204B' 269799001825 GeoRSP system PqqD family protein; Region: geo_PqqD_fam; TIGR04302 269799001826 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 269799001827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799001828 FeS/SAM binding site; other site 269799001829 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 269799001830 GeoRSP system SPASM domain protein; Region: GeoRSP_SPASM; TIGR04304 269799001831 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 269799001832 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 269799001833 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 269799001834 'integration host factor binding site, putative; Gmet_I205A' 269799001835 'integration host factor binding site, putative; Gmet_I205B' 269799001836 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799001837 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 269799001838 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 269799001839 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 269799001840 ResB-like family; Region: ResB; pfam05140 269799001841 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 269799001842 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 269799001843 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 269799001844 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 269799001845 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 269799001846 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 269799001847 ResB-like family; Region: ResB; pfam05140 269799001848 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 269799001849 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 269799001850 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 269799001851 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 269799001852 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 269799001853 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 269799001854 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799001855 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799001856 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 269799001857 spermidine synthase; Provisional; Region: PRK03612 269799001858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799001859 S-adenosylmethionine binding site [chemical binding]; other site 269799001860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799001861 binding surface 269799001862 TPR repeat; Region: TPR_11; pfam13414 269799001863 TPR motif; other site 269799001864 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 269799001865 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269799001866 putative active site [active] 269799001867 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 269799001868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799001869 FeS/SAM binding site; other site 269799001870 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 269799001871 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 269799001872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799001873 FeS/SAM binding site; other site 269799001874 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 269799001875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799001876 binding surface 269799001877 TPR motif; other site 269799001878 TPR repeat; Region: TPR_11; pfam13414 269799001879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799001880 binding surface 269799001881 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799001882 TPR motif; other site 269799001883 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799001884 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 269799001885 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 269799001886 Ligand binding site; other site 269799001887 Putative Catalytic site; other site 269799001888 DXD motif; other site 269799001889 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 269799001890 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 269799001891 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 269799001892 Right handed beta helix region; Region: Beta_helix; pfam13229 269799001893 ResB-like family; Region: ResB; pfam05140 269799001894 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 269799001895 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 269799001896 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 269799001897 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 269799001898 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 269799001899 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799001900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799001901 FeS/SAM binding site; other site 269799001902 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799001903 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799001904 heme-binding residues [chemical binding]; other site 269799001905 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799001906 heme-binding residues [chemical binding]; other site 269799001907 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799001908 heme-binding residues [chemical binding]; other site 269799001909 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799001910 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 269799001911 heme-binding residues [chemical binding]; other site 269799001912 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 269799001913 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 269799001914 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 269799001915 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799001916 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799001917 heme-binding residues [chemical binding]; other site 269799001918 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799001919 heme-binding residues [chemical binding]; other site 269799001920 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 269799001921 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 269799001922 tartrate dehydrogenase; Region: TTC; TIGR02089 269799001923 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 269799001924 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 269799001925 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 269799001926 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 269799001927 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 269799001928 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 269799001929 dimerization interface 3.5A [polypeptide binding]; other site 269799001930 active site 269799001931 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 269799001932 23S rRNA interface [nucleotide binding]; other site 269799001933 L3 interface [polypeptide binding]; other site 269799001934 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 269799001935 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 269799001936 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 269799001937 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 269799001938 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 269799001939 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 269799001940 elongation factor Tu; Reviewed; Region: PRK00049 269799001941 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 269799001942 G1 box; other site 269799001943 GEF interaction site [polypeptide binding]; other site 269799001944 GTP/Mg2+ binding site [chemical binding]; other site 269799001945 Switch I region; other site 269799001946 G2 box; other site 269799001947 G3 box; other site 269799001948 Switch II region; other site 269799001949 G4 box; other site 269799001950 G5 box; other site 269799001951 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 269799001952 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 269799001953 Antibiotic Binding Site [chemical binding]; other site 269799001954 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 269799001955 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 269799001956 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 269799001957 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 269799001958 putative homodimer interface [polypeptide binding]; other site 269799001959 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 269799001960 heterodimer interface [polypeptide binding]; other site 269799001961 homodimer interface [polypeptide binding]; other site 269799001962 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 269799001963 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 269799001964 23S rRNA interface [nucleotide binding]; other site 269799001965 L7/L12 interface [polypeptide binding]; other site 269799001966 putative thiostrepton binding site; other site 269799001967 L25 interface [polypeptide binding]; other site 269799001968 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 269799001969 mRNA/rRNA interface [nucleotide binding]; other site 269799001970 conserved nucleotide sequence; Gmet_P0617 269799001971 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 269799001972 23S rRNA interface [nucleotide binding]; other site 269799001973 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 269799001974 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 269799001975 L11 interface [polypeptide binding]; other site 269799001976 putative EF-Tu interaction site [polypeptide binding]; other site 269799001977 putative EF-G interaction site [polypeptide binding]; other site 269799001978 conserved nucleotide sequence; Gmet_P0619 269799001979 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 269799001980 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 269799001981 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 269799001982 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 269799001983 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 269799001984 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 269799001985 RPB3 interaction site [polypeptide binding]; other site 269799001986 RPB1 interaction site [polypeptide binding]; other site 269799001987 RPB11 interaction site [polypeptide binding]; other site 269799001988 RPB10 interaction site [polypeptide binding]; other site 269799001989 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 269799001990 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 269799001991 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 269799001992 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 269799001993 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 269799001994 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 269799001995 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 269799001996 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 269799001997 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 269799001998 DNA binding site [nucleotide binding] 269799001999 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 269799002000 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 269799002001 S17 interaction site [polypeptide binding]; other site 269799002002 S8 interaction site; other site 269799002003 16S rRNA interaction site [nucleotide binding]; other site 269799002004 streptomycin interaction site [chemical binding]; other site 269799002005 23S rRNA interaction site [nucleotide binding]; other site 269799002006 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 269799002007 30S ribosomal protein S7; Validated; Region: PRK05302 269799002008 elongation factor G; Reviewed; Region: PRK00007 269799002009 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 269799002010 G1 box; other site 269799002011 putative GEF interaction site [polypeptide binding]; other site 269799002012 GTP/Mg2+ binding site [chemical binding]; other site 269799002013 Switch I region; other site 269799002014 G2 box; other site 269799002015 G3 box; other site 269799002016 Switch II region; other site 269799002017 G4 box; other site 269799002018 G5 box; other site 269799002019 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 269799002020 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 269799002021 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 269799002022 elongation factor Tu; Reviewed; Region: PRK00049 269799002023 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 269799002024 G1 box; other site 269799002025 GEF interaction site [polypeptide binding]; other site 269799002026 GTP/Mg2+ binding site [chemical binding]; other site 269799002027 Switch I region; other site 269799002028 G2 box; other site 269799002029 G3 box; other site 269799002030 Switch II region; other site 269799002031 G4 box; other site 269799002032 G5 box; other site 269799002033 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 269799002034 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 269799002035 Antibiotic Binding Site [chemical binding]; other site 269799002036 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 269799002037 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 269799002038 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 269799002039 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 269799002040 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 269799002041 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 269799002042 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 269799002043 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 269799002044 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 269799002045 putative translocon binding site; other site 269799002046 protein-rRNA interface [nucleotide binding]; other site 269799002047 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 269799002048 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 269799002049 G-X-X-G motif; other site 269799002050 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 269799002051 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 269799002052 23S rRNA interface [nucleotide binding]; other site 269799002053 5S rRNA interface [nucleotide binding]; other site 269799002054 putative antibiotic binding site [chemical binding]; other site 269799002055 L25 interface [polypeptide binding]; other site 269799002056 L27 interface [polypeptide binding]; other site 269799002057 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 269799002058 23S rRNA interface [nucleotide binding]; other site 269799002059 putative translocon interaction site; other site 269799002060 signal recognition particle (SRP54) interaction site; other site 269799002061 L23 interface [polypeptide binding]; other site 269799002062 trigger factor interaction site; other site 269799002063 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 269799002064 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 269799002065 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 269799002066 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 269799002067 RNA binding site [nucleotide binding]; other site 269799002068 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 269799002069 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 269799002070 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 269799002071 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 269799002072 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 269799002073 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 269799002074 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 269799002075 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 269799002076 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 269799002077 5S rRNA interface [nucleotide binding]; other site 269799002078 L27 interface [polypeptide binding]; other site 269799002079 23S rRNA interface [nucleotide binding]; other site 269799002080 L5 interface [polypeptide binding]; other site 269799002081 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 269799002082 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 269799002083 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 269799002084 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 269799002085 23S rRNA binding site [nucleotide binding]; other site 269799002086 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 269799002087 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 269799002088 SecY translocase; Region: SecY; pfam00344 269799002089 adenylate kinase; Reviewed; Region: adk; PRK00279 269799002090 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 269799002091 AMP-binding site [chemical binding]; other site 269799002092 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 269799002093 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 269799002094 active site 269799002095 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 269799002096 30S ribosomal protein S13; Region: bact_S13; TIGR03631 269799002097 30S ribosomal protein S11; Validated; Region: PRK05309 269799002098 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 269799002099 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 269799002100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269799002101 RNA binding surface [nucleotide binding]; other site 269799002102 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 269799002103 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 269799002104 alphaNTD homodimer interface [polypeptide binding]; other site 269799002105 alphaNTD - beta interaction site [polypeptide binding]; other site 269799002106 alphaNTD - beta' interaction site [polypeptide binding]; other site 269799002107 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 269799002108 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 269799002109 palindrome; Gmet_R0071 269799002110 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269799002111 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 269799002112 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269799002113 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 269799002114 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269799002115 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 269799002116 Walker A/P-loop; other site 269799002117 ATP binding site [chemical binding]; other site 269799002118 Q-loop/lid; other site 269799002119 ABC transporter signature motif; other site 269799002120 Walker B; other site 269799002121 D-loop; other site 269799002122 H-loop/switch region; other site 269799002123 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269799002124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799002125 Walker A/P-loop; other site 269799002126 ATP binding site [chemical binding]; other site 269799002127 Q-loop/lid; other site 269799002128 ABC transporter signature motif; other site 269799002129 Walker B; other site 269799002130 D-loop; other site 269799002131 H-loop/switch region; other site 269799002132 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 269799002133 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 269799002134 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799002135 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 269799002136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799002137 active site 269799002138 phosphorylation site [posttranslational modification] 269799002139 intermolecular recognition site; other site 269799002140 dimerization interface [polypeptide binding]; other site 269799002141 ANTAR domain; Region: ANTAR; pfam03861 269799002142 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 269799002143 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269799002144 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269799002145 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 269799002146 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269799002147 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269799002148 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 269799002149 IMP binding site; other site 269799002150 dimer interface [polypeptide binding]; other site 269799002151 partial ornithine binding site; other site 269799002152 conserved nucleotide sequence; Gmet_R0072 269799002153 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 269799002154 nitrogenase iron protein; Region: nifH; TIGR01287 269799002155 Nucleotide-binding sites [chemical binding]; other site 269799002156 Walker A motif; other site 269799002157 Switch I region of nucleotide binding site; other site 269799002158 Fe4S4 binding sites [ion binding]; other site 269799002159 Switch II region of nucleotide binding site; other site 269799002160 conserved nucleotide sequence; Gmet_R1008 269799002161 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 269799002162 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 269799002163 MoFe protein alpha/beta subunit interactions; other site 269799002164 Alpha subunit P cluster binding residues; other site 269799002165 FeMoco binding residues [chemical binding]; other site 269799002166 MoFe protein alpha subunit/Fe protein contacts; other site 269799002167 MoFe protein dimer/ dimer interactions; other site 269799002168 'integration host factor binding site, putative; Gmet_I107A' 269799002169 'integration host factor binding site, putative; Gmet_I107B' 269799002170 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 269799002171 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 269799002172 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 269799002173 MoFe protein beta/alpha subunit interactions; other site 269799002174 Beta subunit P cluster binding residues; other site 269799002175 MoFe protein beta subunit/Fe protein contacts; other site 269799002176 MoFe protein dimer/ dimer interactions; other site 269799002177 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 269799002178 metal binding triad [ion binding]; metal-binding site 269799002179 PAS domain S-box; Region: sensory_box; TIGR00229 269799002180 PAS domain S-box; Region: sensory_box; TIGR00229 269799002181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799002182 putative active site [active] 269799002183 heme pocket [chemical binding]; other site 269799002184 PAS domain; Region: PAS_9; pfam13426 269799002185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799002186 putative active site [active] 269799002187 heme pocket [chemical binding]; other site 269799002188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799002189 dimer interface [polypeptide binding]; other site 269799002190 phosphorylation site [posttranslational modification] 269799002191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002192 ATP binding site [chemical binding]; other site 269799002193 Mg2+ binding site [ion binding]; other site 269799002194 G-X-G motif; other site 269799002195 Rubrerythrin [Energy production and conversion]; Region: COG1592 269799002196 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 269799002197 binuclear metal center [ion binding]; other site 269799002198 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 269799002199 iron binding site [ion binding]; other site 269799002200 Rubrerythrin [Energy production and conversion]; Region: COG1592 269799002201 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 269799002202 binuclear metal center [ion binding]; other site 269799002203 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 269799002204 iron binding site [ion binding]; other site 269799002205 bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477 269799002206 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 269799002207 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 269799002208 'integration host factor binding site, putative; Gmet_I108A' 269799002209 'integration host factor binding site, putative; Gmet_I108B' 269799002210 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799002211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799002212 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799002213 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 269799002214 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 269799002215 4Fe-4S binding domain; Region: Fer4; cl02805 269799002216 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 269799002217 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 269799002218 Restriction endonuclease [Defense mechanisms]; Region: COG3587 269799002219 Restriction endonuclease [Defense mechanisms]; Region: COG3587 269799002220 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 269799002221 DNA methylase; Region: N6_N4_Mtase; pfam01555 269799002222 DNA methylase; Region: N6_N4_Mtase; pfam01555 269799002223 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 269799002224 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 269799002225 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 269799002226 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 269799002227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799002228 Radical SAM superfamily; Region: Radical_SAM; pfam04055 269799002229 FeS/SAM binding site; other site 269799002230 putative acetyltransferase; Provisional; Region: PRK03624 269799002231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269799002232 Coenzyme A binding pocket [chemical binding]; other site 269799002233 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799002234 Ligand binding site [chemical binding]; other site 269799002235 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799002236 4Fe-4S binding domain; Region: Fer4; pfam00037 269799002237 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799002238 4Fe-4S binding domain; Region: Fer4; pfam00037 269799002239 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799002240 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269799002241 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799002242 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799002243 4Fe-4S binding domain; Region: Fer4; cl02805 269799002244 Cysteine-rich domain; Region: CCG; pfam02754 269799002245 Cysteine-rich domain; Region: CCG; pfam02754 269799002246 sensor protein QseC; Provisional; Region: PRK10337 269799002247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799002248 dimer interface [polypeptide binding]; other site 269799002249 phosphorylation site [posttranslational modification] 269799002250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002251 ATP binding site [chemical binding]; other site 269799002252 Mg2+ binding site [ion binding]; other site 269799002253 G-X-G motif; other site 269799002254 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 269799002255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799002256 active site 269799002257 phosphorylation site [posttranslational modification] 269799002258 intermolecular recognition site; other site 269799002259 dimerization interface [polypeptide binding]; other site 269799002260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269799002261 DNA binding site [nucleotide binding] 269799002262 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 269799002263 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 269799002264 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 269799002265 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 269799002266 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 269799002267 active site 269799002268 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 269799002269 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 269799002270 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 269799002271 active site 269799002272 catalytic residues [active] 269799002273 metal binding site [ion binding]; metal-binding site 269799002274 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 269799002275 Nitrogen regulatory protein P-II; Region: P-II; smart00938 269799002276 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 269799002277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799002278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799002279 dimer interface [polypeptide binding]; other site 269799002280 phosphorylation site [posttranslational modification] 269799002281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002282 ATP binding site [chemical binding]; other site 269799002283 Mg2+ binding site [ion binding]; other site 269799002284 G-X-G motif; other site 269799002285 'integration host factor binding site, putative; Gmet_I206A' 269799002286 'integration host factor binding site, putative; Gmet_I206B' 269799002287 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 269799002288 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 269799002289 active site 269799002290 dimerization interface [polypeptide binding]; other site 269799002291 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 269799002292 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269799002293 homodimer interface [polypeptide binding]; other site 269799002294 substrate-cofactor binding pocket; other site 269799002295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799002296 catalytic residue [active] 269799002297 four heptanucleotide repeats; Gmet_H416 269799002298 cystathionine beta-lyase; Provisional; Region: PRK08064 269799002299 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269799002300 homodimer interface [polypeptide binding]; other site 269799002301 substrate-cofactor binding pocket; other site 269799002302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799002303 catalytic residue [active] 269799002304 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799002305 dimerization interface [polypeptide binding]; other site 269799002306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799002307 PAS domain; Region: PAS_9; pfam13426 269799002308 putative active site [active] 269799002309 heme pocket [chemical binding]; other site 269799002310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799002311 metal binding site [ion binding]; metal-binding site 269799002312 active site 269799002313 I-site; other site 269799002314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269799002315 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269799002316 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269799002317 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269799002318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799002319 dimerization interface [polypeptide binding]; other site 269799002320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799002321 dimer interface [polypeptide binding]; other site 269799002322 phosphorylation site [posttranslational modification] 269799002323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002324 ATP binding site [chemical binding]; other site 269799002325 Mg2+ binding site [ion binding]; other site 269799002326 G-X-G motif; other site 269799002327 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799002328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799002329 active site 269799002330 phosphorylation site [posttranslational modification] 269799002331 intermolecular recognition site; other site 269799002332 dimerization interface [polypeptide binding]; other site 269799002333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799002334 Walker A motif; other site 269799002335 ATP binding site [chemical binding]; other site 269799002336 Walker B motif; other site 269799002337 arginine finger; other site 269799002338 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799002339 conserved nucleotide sequence; Gmet_P0703 269799002340 conserved nucleotide sequence; Gmet_P0704 269799002341 glycogen synthase; Provisional; Region: glgA; PRK00654 269799002342 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 269799002343 ADP-binding pocket [chemical binding]; other site 269799002344 homodimer interface [polypeptide binding]; other site 269799002345 Homeodomain-like domain; Region: HTH_23; pfam13384 269799002346 Winged helix-turn helix; Region: HTH_29; pfam13551 269799002347 Integrase core domain; Region: rve; pfam00665 269799002348 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 269799002349 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 269799002350 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 269799002351 putative active site; other site 269799002352 catalytic triad [active] 269799002353 putative dimer interface [polypeptide binding]; other site 269799002354 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 269799002355 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 269799002356 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799002357 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269799002358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799002359 dimerization interface [polypeptide binding]; other site 269799002360 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799002361 dimer interface [polypeptide binding]; other site 269799002362 putative CheW interface [polypeptide binding]; other site 269799002363 PAS domain S-box; Region: sensory_box; TIGR00229 269799002364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799002365 putative active site [active] 269799002366 heme pocket [chemical binding]; other site 269799002367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799002368 dimer interface [polypeptide binding]; other site 269799002369 phosphorylation site [posttranslational modification] 269799002370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002371 ATP binding site [chemical binding]; other site 269799002372 Mg2+ binding site [ion binding]; other site 269799002373 G-X-G motif; other site 269799002374 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 269799002375 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 269799002376 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 269799002377 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 269799002378 putative NADH binding site [chemical binding]; other site 269799002379 putative active site [active] 269799002380 nudix motif; other site 269799002381 putative metal binding site [ion binding]; other site 269799002382 four heptanucleotide repeats; Gmet_H417 269799002383 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 269799002384 conserved nucleotide sequence; Gmet_R0074 269799002385 conserved nucleotide sequence; Gmet_R0075 269799002386 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 269799002387 Methyltransferase domain; Region: Methyltransf_18; pfam12847 269799002388 S-adenosylmethionine binding site [chemical binding]; other site 269799002389 four heptanucleotide repeats; Gmet_H418 269799002390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 269799002391 SEC-C motif; Region: SEC-C; pfam02810 269799002392 SEC-C motif; Region: SEC-C; pfam02810 269799002393 'integration host factor binding site, putative; Gmet_I109A' 269799002394 'integration host factor binding site, putative; Gmet_I109B' 269799002395 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799002396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799002397 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799002398 ribonuclease Z; Provisional; Region: PRK02126 269799002399 PilZ domain; Region: PilZ; cl01260 269799002400 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 269799002401 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 269799002402 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 269799002403 nucleophilic elbow; other site 269799002404 catalytic triad; other site 269799002405 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 269799002406 TPR repeat; Region: TPR_11; pfam13414 269799002407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799002408 binding surface 269799002409 TPR motif; other site 269799002410 TPR repeat; Region: TPR_11; pfam13414 269799002411 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 269799002412 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 269799002413 CoA-ligase; Region: Ligase_CoA; pfam00549 269799002414 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 269799002415 CoA binding domain; Region: CoA_binding; smart00881 269799002416 CoA-ligase; Region: Ligase_CoA; pfam00549 269799002417 PAS domain; Region: PAS_9; pfam13426 269799002418 PAS domain; Region: PAS_9; pfam13426 269799002419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799002420 putative active site [active] 269799002421 heme pocket [chemical binding]; other site 269799002422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799002423 dimer interface [polypeptide binding]; other site 269799002424 phosphorylation site [posttranslational modification] 269799002425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002426 ATP binding site [chemical binding]; other site 269799002427 Mg2+ binding site [ion binding]; other site 269799002428 G-X-G motif; other site 269799002429 aspartate aminotransferase; Provisional; Region: PRK06836 269799002430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269799002431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799002432 homodimer interface [polypeptide binding]; other site 269799002433 catalytic residue [active] 269799002434 PilX N-terminal; Region: PilX_N; pfam14341 269799002435 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 269799002436 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269799002437 metal binding triad; other site 269799002438 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 269799002439 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 269799002440 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 269799002441 Na binding site [ion binding]; other site 269799002442 Protein of unknown function, DUF485; Region: DUF485; pfam04341 269799002443 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 269799002444 Transcriptional regulator [Transcription]; Region: IclR; COG1414 269799002445 Bacterial transcriptional regulator; Region: IclR; pfam01614 269799002446 hypothetical protein; Validated; Region: PRK00110 269799002447 conserved nucleotide sequence; Gmet_R6002 269799002448 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 269799002449 active site 269799002450 putative DNA-binding cleft [nucleotide binding]; other site 269799002451 dimer interface [polypeptide binding]; other site 269799002452 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 269799002453 RuvA N terminal domain; Region: RuvA_N; pfam01330 269799002454 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 269799002455 conserved palindrome; Gmet_R5002 269799002456 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 269799002457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799002458 Walker A motif; other site 269799002459 ATP binding site [chemical binding]; other site 269799002460 Walker B motif; other site 269799002461 arginine finger; other site 269799002462 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 269799002463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799002464 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 269799002465 Walker A motif; other site 269799002466 ATP binding site [chemical binding]; other site 269799002467 Walker B motif; other site 269799002468 arginine finger; other site 269799002469 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 269799002470 active site 269799002471 catalytic triad [active] 269799002472 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 269799002473 conserved nucleotide sequence; Gmet_P0749 269799002474 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269799002475 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269799002476 ligand binding site [chemical binding]; other site 269799002477 flexible hinge region; other site 269799002478 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 269799002479 putative switch regulator; other site 269799002480 non-specific DNA interactions [nucleotide binding]; other site 269799002481 DNA binding site [nucleotide binding] 269799002482 sequence specific DNA binding site [nucleotide binding]; other site 269799002483 putative cAMP binding site [chemical binding]; other site 269799002484 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 269799002485 active site 269799002486 catalytic triad [active] 269799002487 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 269799002488 conserved nucleotide sequence; Gmet_P0751 269799002489 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 269799002490 Ligand Binding Site [chemical binding]; other site 269799002491 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 269799002492 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 269799002493 Double zinc ribbon; Region: DZR; pfam12773 269799002494 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 269799002495 Domain of unknown function (DUF329); Region: DUF329; cl01144 269799002496 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 269799002497 Predicted DNA-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG1571 269799002498 Uncharacterized conserved protein [Function unknown]; Region: COG3937 269799002499 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 269799002500 ABC1 family; Region: ABC1; cl17513 269799002501 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 269799002502 Uncharacterized conserved protein [Function unknown]; Region: COG2006 269799002503 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799002504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799002505 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799002506 phosphorylation site [posttranslational modification] 269799002507 intermolecular recognition site; other site 269799002508 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799002509 GAF domain; Region: GAF; cl17456 269799002510 GAF domain; Region: GAF; pfam01590 269799002511 GAF domain; Region: GAF_2; pfam13185 269799002512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799002513 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 269799002514 Walker A motif; other site 269799002515 ATP binding site [chemical binding]; other site 269799002516 Walker B motif; other site 269799002517 arginine finger; other site 269799002518 putative hydrolase; Provisional; Region: PRK02113 269799002519 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 269799002520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799002521 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799002522 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 269799002523 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 269799002524 phosphoenolpyruvate synthase; Validated; Region: PRK06464 269799002525 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 269799002526 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269799002527 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269799002528 conserved nucleotide sequence; Gmet_I402 269799002529 conserved nucleotide sequence; Gmet_I403 269799002530 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 269799002531 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 269799002532 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 269799002533 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 269799002534 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269799002535 ligand binding site [chemical binding]; other site 269799002536 flexible hinge region; other site 269799002537 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799002538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799002539 metal binding site [ion binding]; metal-binding site 269799002540 active site 269799002541 I-site; other site 269799002542 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 269799002543 active site clefts [active] 269799002544 zinc binding site [ion binding]; other site 269799002545 dimer interface [polypeptide binding]; other site 269799002546 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 269799002547 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799002548 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269799002549 ligand binding site [chemical binding]; other site 269799002550 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269799002551 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799002552 ligand binding site [chemical binding]; other site 269799002553 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799002554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799002555 active site 269799002556 phosphorylation site [posttranslational modification] 269799002557 intermolecular recognition site; other site 269799002558 dimerization interface [polypeptide binding]; other site 269799002559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799002560 Walker A motif; other site 269799002561 ATP binding site [chemical binding]; other site 269799002562 Walker B motif; other site 269799002563 arginine finger; other site 269799002564 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799002565 'integration host factor binding site, putative; Gmet_I207A' 269799002566 'integration host factor binding site, putative; Gmet_I207B' 269799002567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 269799002568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799002569 dimerization interface [polypeptide binding]; other site 269799002570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799002571 putative active site [active] 269799002572 heme pocket [chemical binding]; other site 269799002573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799002574 dimer interface [polypeptide binding]; other site 269799002575 phosphorylation site [posttranslational modification] 269799002576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002577 ATP binding site [chemical binding]; other site 269799002578 Mg2+ binding site [ion binding]; other site 269799002579 G-X-G motif; other site 269799002580 Response regulator receiver domain; Region: Response_reg; pfam00072 269799002581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799002582 active site 269799002583 phosphorylation site [posttranslational modification] 269799002584 intermolecular recognition site; other site 269799002585 dimerization interface [polypeptide binding]; other site 269799002586 PAS domain; Region: PAS_9; pfam13426 269799002587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002588 ATP binding site [chemical binding]; other site 269799002589 G-X-G motif; other site 269799002590 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 269799002591 CheB methylesterase; Region: CheB_methylest; pfam01339 269799002592 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269799002593 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 269799002594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799002595 S-adenosylmethionine binding site [chemical binding]; other site 269799002596 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 269799002597 PAS domain; Region: PAS_10; pfam13596 269799002598 PBP superfamily domain; Region: PBP_like_2; pfam12849 269799002599 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 269799002600 PAS domain; Region: PAS; smart00091 269799002601 PAS domain; Region: PAS_9; pfam13426 269799002602 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799002603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799002604 metal binding site [ion binding]; metal-binding site 269799002605 active site 269799002606 I-site; other site 269799002607 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269799002608 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 269799002609 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 269799002610 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 269799002611 mce related protein; Region: MCE; pfam02470 269799002612 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 269799002613 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 269799002614 Walker A/P-loop; other site 269799002615 ATP binding site [chemical binding]; other site 269799002616 Q-loop/lid; other site 269799002617 ABC transporter signature motif; other site 269799002618 Walker B; other site 269799002619 D-loop; other site 269799002620 H-loop/switch region; other site 269799002621 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 269799002622 Permease; Region: Permease; pfam02405 269799002623 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 269799002624 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 269799002625 tetrameric interface [polypeptide binding]; other site 269799002626 activator binding site; other site 269799002627 NADP binding site [chemical binding]; other site 269799002628 substrate binding site [chemical binding]; other site 269799002629 catalytic residues [active] 269799002630 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 269799002631 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 269799002632 PrcB C-terminal; Region: PrcB_C; pfam14343 269799002633 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 269799002634 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 269799002635 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 269799002636 Predicted GTPases [General function prediction only]; Region: COG1162 269799002637 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269799002638 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 269799002639 GTPase/Zn-binding domain interface [polypeptide binding]; other site 269799002640 GTP/Mg2+ binding site [chemical binding]; other site 269799002641 G4 box; other site 269799002642 G5 box; other site 269799002643 G1 box; other site 269799002644 Switch I region; other site 269799002645 G2 box; other site 269799002646 G3 box; other site 269799002647 Switch II region; other site 269799002648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799002649 S-adenosylmethionine binding site [chemical binding]; other site 269799002650 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 269799002651 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 269799002652 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 269799002653 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799002654 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799002655 dimer interface [polypeptide binding]; other site 269799002656 putative CheW interface [polypeptide binding]; other site 269799002657 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799002658 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799002659 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 269799002660 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 269799002661 PhnA protein; Region: PhnA; pfam03831 269799002662 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 269799002663 conserved nucleotide sequence; Gmet_P0803 269799002664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799002665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799002666 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 269799002667 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 269799002668 NADP binding site [chemical binding]; other site 269799002669 dimer interface [polypeptide binding]; other site 269799002670 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 269799002671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799002672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269799002673 putative substrate translocation pore; other site 269799002674 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 269799002675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799002676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799002677 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 269799002678 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269799002679 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799002680 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 269799002681 Protein export membrane protein; Region: SecD_SecF; cl14618 269799002682 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 269799002683 'integration host factor binding site, putative; Gmet_I110A' 269799002684 'integration host factor binding site, putative; Gmet_I110B' 269799002685 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799002686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799002687 active site 269799002688 phosphorylation site [posttranslational modification] 269799002689 intermolecular recognition site; other site 269799002690 dimerization interface [polypeptide binding]; other site 269799002691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799002692 Walker A motif; other site 269799002693 ATP binding site [chemical binding]; other site 269799002694 Walker B motif; other site 269799002695 arginine finger; other site 269799002696 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 269799002697 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 269799002698 active site 269799002699 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 269799002700 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 269799002701 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 269799002702 SurA N-terminal domain; Region: SurA_N_3; cl07813 269799002703 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 269799002704 conserved nucleotide sequence; Gmet_P0816 269799002705 pyruvate carboxylase; Reviewed; Region: PRK12999 269799002706 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269799002707 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 269799002708 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269799002709 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 269799002710 active site 269799002711 catalytic residues [active] 269799002712 metal binding site [ion binding]; metal-binding site 269799002713 homodimer binding site [polypeptide binding]; other site 269799002714 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269799002715 carboxyltransferase (CT) interaction site; other site 269799002716 biotinylation site [posttranslational modification]; other site 269799002717 conserved nucleotide sequence; Gmet_P0817 269799002718 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 269799002719 putative FMN binding site [chemical binding]; other site 269799002720 NADPH bind site [chemical binding]; other site 269799002721 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 269799002722 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269799002723 homodimer interface [polypeptide binding]; other site 269799002724 substrate-cofactor binding pocket; other site 269799002725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799002726 catalytic residue [active] 269799002727 conserved nucleotide sequence; Gmet_P0820 269799002728 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799002729 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799002730 dimerization interface [polypeptide binding]; other site 269799002731 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799002732 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799002733 dimer interface [polypeptide binding]; other site 269799002734 putative CheW interface [polypeptide binding]; other site 269799002735 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 269799002736 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269799002737 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 269799002738 putative NAD(P) binding site [chemical binding]; other site 269799002739 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799002740 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 269799002741 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 269799002742 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 269799002743 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 269799002744 NAD(P) binding site [chemical binding]; other site 269799002745 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 269799002746 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 269799002747 active site 269799002748 catalytic site [active] 269799002749 Hemerythrin; Region: Hemerythrin; cd12107 269799002750 Fe binding site [ion binding]; other site 269799002751 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 269799002752 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 269799002753 Ligand binding site; other site 269799002754 metal-binding site 269799002755 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 269799002756 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 269799002757 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 269799002758 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 269799002759 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 269799002760 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 269799002761 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799002762 catalytic loop [active] 269799002763 iron binding site [ion binding]; other site 269799002764 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 269799002765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799002766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799002767 metal binding site [ion binding]; metal-binding site 269799002768 active site 269799002769 I-site; other site 269799002770 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 269799002771 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 269799002772 active site 269799002773 metal binding site [ion binding]; metal-binding site 269799002774 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 269799002775 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 269799002776 substrate-cofactor binding pocket; other site 269799002777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799002778 catalytic residue [active] 269799002779 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 269799002780 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 269799002781 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 269799002782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799002783 S-adenosylmethionine binding site [chemical binding]; other site 269799002784 octanucleotide repeats; Gmet_R0152 269799002785 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 269799002786 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 269799002787 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 269799002788 putative RNA binding site [nucleotide binding]; other site 269799002789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799002790 S-adenosylmethionine binding site [chemical binding]; other site 269799002791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269799002792 dimerization interface [polypeptide binding]; other site 269799002793 putative DNA binding site [nucleotide binding]; other site 269799002794 putative Zn2+ binding site [ion binding]; other site 269799002795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269799002796 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 269799002797 Walker A/P-loop; other site 269799002798 ATP binding site [chemical binding]; other site 269799002799 Q-loop/lid; other site 269799002800 ABC transporter signature motif; other site 269799002801 Walker B; other site 269799002802 D-loop; other site 269799002803 H-loop/switch region; other site 269799002804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 269799002805 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 269799002806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 269799002807 Walker A/P-loop; other site 269799002808 ATP binding site [chemical binding]; other site 269799002809 Q-loop/lid; other site 269799002810 ABC transporter signature motif; other site 269799002811 Walker B; other site 269799002812 D-loop; other site 269799002813 H-loop/switch region; other site 269799002814 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 269799002815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799002816 dimerization interface [polypeptide binding]; other site 269799002817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799002818 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799002819 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 269799002820 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799002821 Zn2+ binding site [ion binding]; other site 269799002822 Mg2+ binding site [ion binding]; other site 269799002823 Stage II sporulation protein; Region: SpoIID; pfam08486 269799002824 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 269799002825 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 269799002826 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 269799002827 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 269799002828 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 269799002829 Preprotein translocase subunit; Region: YajC; pfam02699 269799002830 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 269799002831 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 269799002832 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 269799002833 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 269799002834 Protein export membrane protein; Region: SecD_SecF; pfam02355 269799002835 TPR repeat; Region: TPR_11; pfam13414 269799002836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799002837 binding surface 269799002838 TPR motif; other site 269799002839 TPR repeat; Region: TPR_11; pfam13414 269799002840 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 269799002841 DHH family; Region: DHH; pfam01368 269799002842 DHHA1 domain; Region: DHHA1; pfam02272 269799002843 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 269799002844 Cation efflux family; Region: Cation_efflux; pfam01545 269799002845 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799002846 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 269799002847 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269799002848 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269799002849 Walker A motif; other site 269799002850 ATP binding site [chemical binding]; other site 269799002851 Walker B motif; other site 269799002852 Chorismate mutase type II; Region: CM_2; pfam01817 269799002853 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 269799002854 Prephenate dehydratase; Region: PDT; pfam00800 269799002855 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 269799002856 putative L-Phe binding site [chemical binding]; other site 269799002857 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 269799002858 prephenate dehydrogenase; Validated; Region: PRK08507 269799002859 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 269799002860 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 269799002861 hinge; other site 269799002862 active site 269799002863 cytidylate kinase; Provisional; Region: cmk; PRK00023 269799002864 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 269799002865 CMP-binding site; other site 269799002866 The sites determining sugar specificity; other site 269799002867 LytB protein; Region: LYTB; cl00507 269799002868 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 269799002869 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 269799002870 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 269799002871 RNA binding site [nucleotide binding]; other site 269799002872 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 269799002873 RNA binding site [nucleotide binding]; other site 269799002874 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 269799002875 RNA binding site [nucleotide binding]; other site 269799002876 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269799002877 RNA binding site [nucleotide binding]; other site 269799002878 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 269799002879 RNA binding site [nucleotide binding]; other site 269799002880 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 269799002881 RNA binding site [nucleotide binding]; other site 269799002882 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269799002883 IHF dimer interface [polypeptide binding]; other site 269799002884 IHF - DNA interface [nucleotide binding]; other site 269799002885 serine O-acetyltransferase; Region: cysE; TIGR01172 269799002886 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 269799002887 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 269799002888 trimer interface [polypeptide binding]; other site 269799002889 active site 269799002890 substrate binding site [chemical binding]; other site 269799002891 CoA binding site [chemical binding]; other site 269799002892 conserved nucleotide sequence; Gmet_R7001 269799002893 Transcriptional regulator; Region: Rrf2; cl17282 269799002894 Rrf2 family protein; Region: rrf2_super; TIGR00738 269799002895 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 269799002896 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 269799002897 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799002898 catalytic residue [active] 269799002899 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 269799002900 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 269799002901 Ligand Binding Site [chemical binding]; other site 269799002902 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 269799002903 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 269799002904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799002905 FeS/SAM binding site; other site 269799002906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799002907 Response regulator receiver domain; Region: Response_reg; pfam00072 269799002908 active site 269799002909 phosphorylation site [posttranslational modification] 269799002910 intermolecular recognition site; other site 269799002911 dimerization interface [polypeptide binding]; other site 269799002912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799002913 dimer interface [polypeptide binding]; other site 269799002914 phosphorylation site [posttranslational modification] 269799002915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799002916 ATP binding site [chemical binding]; other site 269799002917 Mg2+ binding site [ion binding]; other site 269799002918 G-X-G motif; other site 269799002919 hypothetical protein; Provisional; Region: PRK05170 269799002920 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 269799002921 catalytic core [active] 269799002922 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 269799002923 exopolyphosphatase; Region: exo_poly_only; TIGR03706 269799002924 Cell division protein FtsA; Region: FtsA; cl17206 269799002925 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 269799002926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799002927 Zn2+ binding site [ion binding]; other site 269799002928 Mg2+ binding site [ion binding]; other site 269799002929 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 269799002930 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 269799002931 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 269799002932 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 269799002933 putative active site [active] 269799002934 putative catalytic site [active] 269799002935 putative Zn binding site [ion binding]; other site 269799002936 conserved nucleotide sequence; Gmet_R1009 269799002937 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 269799002938 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 269799002939 NAD binding site [chemical binding]; other site 269799002940 substrate binding site [chemical binding]; other site 269799002941 active site 269799002942 putative formyltransferase; Provisional; Region: PRK06988 269799002943 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 269799002944 active site 269799002945 substrate binding site [chemical binding]; other site 269799002946 cosubstrate binding site; other site 269799002947 catalytic site [active] 269799002948 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 269799002949 active site 269799002950 hexamer interface [polypeptide binding]; other site 269799002951 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 269799002952 Ligand binding site; other site 269799002953 Putative Catalytic site; other site 269799002954 DXD motif; other site 269799002955 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 269799002956 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 269799002957 inhibitor-cofactor binding pocket; inhibition site 269799002958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799002959 catalytic residue [active] 269799002960 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 269799002961 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 269799002962 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 269799002963 Peptidase family U32; Region: Peptidase_U32; pfam01136 269799002964 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799002965 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 269799002966 DNA protecting protein DprA; Region: dprA; TIGR00732 269799002967 DNA topoisomerase I; Validated; Region: PRK06599 269799002968 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 269799002969 active site 269799002970 interdomain interaction site; other site 269799002971 putative metal-binding site [ion binding]; other site 269799002972 nucleotide binding site [chemical binding]; other site 269799002973 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 269799002974 domain I; other site 269799002975 DNA binding groove [nucleotide binding] 269799002976 phosphate binding site [ion binding]; other site 269799002977 domain II; other site 269799002978 domain III; other site 269799002979 nucleotide binding site [chemical binding]; other site 269799002980 catalytic site [active] 269799002981 domain IV; other site 269799002982 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 269799002983 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 269799002984 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 269799002985 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 269799002986 conserved nucleotide sequence; Gmet_P0892 269799002987 'integration host factor binding site, putative; Gmet_I111A' 269799002988 'integration host factor binding site, putative; Gmet_I111B' 269799002989 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 269799002990 Glucose inhibited division protein A; Region: GIDA; pfam01134 269799002991 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 269799002992 Maf-like protein; Region: Maf; pfam02545 269799002993 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 269799002994 active site 269799002995 dimer interface [polypeptide binding]; other site 269799002996 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 269799002997 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269799002998 catalytic residue [active] 269799002999 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 269799003000 putative active site [active] 269799003001 putative metal binding site [ion binding]; other site 269799003002 pyrroline-5-carboxylate reductase; Region: PLN02688 269799003003 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 269799003004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799003005 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799003006 conserved nucleotide sequence; Gmet_R0076 269799003007 conserved nucleotide sequence; Gmet_R0077 269799003008 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 269799003009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799003010 non-specific DNA binding site [nucleotide binding]; other site 269799003011 salt bridge; other site 269799003012 sequence-specific DNA binding site [nucleotide binding]; other site 269799003013 Cupin domain; Region: Cupin_2; pfam07883 269799003014 conserved nucleotide sequence; Gmet_R1010 269799003015 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 269799003016 conserved nucleotide sequence; Gmet_R1011 269799003017 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 269799003018 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 269799003019 dimer interface [polypeptide binding]; other site 269799003020 active site 269799003021 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269799003022 catalytic residues [active] 269799003023 substrate binding site [chemical binding]; other site 269799003024 conserved nucleotide sequence; Gmet_R1012 269799003025 conserved nucleotide sequence; Gmet_R1013 269799003026 arginine decarboxylase; Provisional; Region: PRK05354 269799003027 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 269799003028 active site 269799003029 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269799003030 catalytic residues [active] 269799003031 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 269799003032 Ycf46; Provisional; Region: ycf46; CHL00195 269799003033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799003034 Walker A motif; other site 269799003035 ATP binding site [chemical binding]; other site 269799003036 Walker B motif; other site 269799003037 arginine finger; other site 269799003038 four heptanucleotide repeats; Gmet_H419 269799003039 four heptanucleotide repeats; Gmet_H420 269799003040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799003041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269799003042 putative substrate translocation pore; other site 269799003043 conserved nucleotide sequence; Gmet_P0908 269799003044 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 269799003045 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 269799003046 palindrome; Gmet_R0078 269799003047 conserved nucleotide sequence; Gmet_P0911 269799003048 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 269799003049 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 269799003050 active site 269799003051 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 269799003052 ATP binding site [chemical binding]; other site 269799003053 active site 269799003054 substrate binding site [chemical binding]; other site 269799003055 SurA N-terminal domain; Region: SurA_N_3; pfam13624 269799003056 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 269799003057 rod shape-determining protein MreB; Provisional; Region: PRK13927 269799003058 MreB and similar proteins; Region: MreB_like; cd10225 269799003059 nucleotide binding site [chemical binding]; other site 269799003060 Mg binding site [ion binding]; other site 269799003061 putative protofilament interaction site [polypeptide binding]; other site 269799003062 RodZ interaction site [polypeptide binding]; other site 269799003063 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 269799003064 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269799003065 active site 269799003066 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 269799003067 dimer interface [polypeptide binding]; other site 269799003068 active site 269799003069 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 269799003070 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 269799003071 putative ribose interaction site [chemical binding]; other site 269799003072 putative ADP binding site [chemical binding]; other site 269799003073 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 269799003074 active site 269799003075 nucleotide binding site [chemical binding]; other site 269799003076 HIGH motif; other site 269799003077 KMSKS motif; other site 269799003078 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 269799003079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799003080 active site 269799003081 motif I; other site 269799003082 motif II; other site 269799003083 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 269799003084 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 269799003085 tetramer interface; other site 269799003086 substrate binding site; other site 269799003087 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 269799003088 rod shape-determining protein MreC; Provisional; Region: PRK13922 269799003089 rod shape-determining protein MreC; Region: MreC; pfam04085 269799003090 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 269799003091 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 269799003092 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 269799003093 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 269799003094 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 269799003095 six hairpins; Gmet_R0079 269799003096 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 269799003097 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 269799003098 active site 269799003099 catalytic residues [active] 269799003100 SurA N-terminal domain; Region: SurA_N_3; cl07813 269799003101 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 269799003102 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 269799003103 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 269799003104 Cadherin repeat-like domain; Region: CA_like; cl15786 269799003105 Ca2+ binding site [ion binding]; other site 269799003106 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 269799003107 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 269799003108 putative acyl-acceptor binding pocket; other site 269799003109 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 269799003110 RNA/DNA hybrid binding site [nucleotide binding]; other site 269799003111 active site 269799003112 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 269799003113 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 269799003114 active site 269799003115 phosphoglycolate phosphatase; Provisional; Region: PRK13222 269799003116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799003117 motif II; other site 269799003118 6-phosphofructokinase; Provisional; Region: PRK03202 269799003119 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 269799003120 active site 269799003121 ADP/pyrophosphate binding site [chemical binding]; other site 269799003122 dimerization interface [polypeptide binding]; other site 269799003123 allosteric effector site; other site 269799003124 fructose-1,6-bisphosphate binding site; other site 269799003125 recombination factor protein RarA; Reviewed; Region: PRK13342 269799003126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799003127 Walker A motif; other site 269799003128 ATP binding site [chemical binding]; other site 269799003129 Walker B motif; other site 269799003130 arginine finger; other site 269799003131 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 269799003132 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 269799003133 homodimer interface [polypeptide binding]; other site 269799003134 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 269799003135 active site pocket [active] 269799003136 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 269799003137 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 269799003138 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 269799003139 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 269799003140 Walker A/P-loop; other site 269799003141 ATP binding site [chemical binding]; other site 269799003142 Q-loop/lid; other site 269799003143 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 269799003144 ABC transporter signature motif; other site 269799003145 Walker B; other site 269799003146 D-loop; other site 269799003147 H-loop/switch region; other site 269799003148 HDOD domain; Region: HDOD; pfam08668 269799003149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799003150 Zn2+ binding site [ion binding]; other site 269799003151 Mg2+ binding site [ion binding]; other site 269799003152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799003153 active site 269799003154 phosphorylation site [posttranslational modification] 269799003155 intermolecular recognition site; other site 269799003156 dimerization interface [polypeptide binding]; other site 269799003157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799003158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799003159 metal binding site [ion binding]; metal-binding site 269799003160 active site 269799003161 I-site; other site 269799003162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269799003163 Coenzyme A binding pocket [chemical binding]; other site 269799003164 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 269799003165 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 269799003166 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269799003167 dimer interface [polypeptide binding]; other site 269799003168 PYR/PP interface [polypeptide binding]; other site 269799003169 TPP binding site [chemical binding]; other site 269799003170 substrate binding site [chemical binding]; other site 269799003171 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 269799003172 TPP-binding site; other site 269799003173 4Fe-4S binding domain; Region: Fer4; pfam00037 269799003174 indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK06274 269799003175 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799003176 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 269799003177 acyl-activating enzyme (AAE) consensus motif; other site 269799003178 AMP binding site [chemical binding]; other site 269799003179 active site 269799003180 CoA binding site [chemical binding]; other site 269799003181 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 269799003182 DEAD/DEAH box helicase; Region: DEAD; pfam00270 269799003183 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 269799003184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 269799003185 nucleotide binding region [chemical binding]; other site 269799003186 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 269799003187 heterotetramer interface [polypeptide binding]; other site 269799003188 active site pocket [active] 269799003189 cleavage site 269799003190 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 269799003191 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 269799003192 Beta-lactamase; Region: Beta-lactamase; pfam00144 269799003193 Response regulator receiver domain; Region: Response_reg; pfam00072 269799003194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799003195 active site 269799003196 phosphorylation site [posttranslational modification] 269799003197 intermolecular recognition site; other site 269799003198 dimerization interface [polypeptide binding]; other site 269799003199 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 269799003200 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 269799003201 HIGH motif; other site 269799003202 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 269799003203 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 269799003204 active site 269799003205 KMSKS motif; other site 269799003206 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 269799003207 tRNA binding surface [nucleotide binding]; other site 269799003208 anticodon binding site; other site 269799003209 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 269799003210 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799003211 GAF domain; Region: GAF_2; pfam13185 269799003212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799003213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799003214 metal binding site [ion binding]; metal-binding site 269799003215 active site 269799003216 I-site; other site 269799003217 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269799003218 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799003219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799003220 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799003221 'integration host factor binding site, putative; Gmet_I112A' 269799003222 'integration host factor binding site, putative; Gmet_I112B' 269799003223 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 269799003224 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 269799003225 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 269799003226 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 269799003227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799003228 dimerization interface [polypeptide binding]; other site 269799003229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799003230 dimer interface [polypeptide binding]; other site 269799003231 phosphorylation site [posttranslational modification] 269799003232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799003233 ATP binding site [chemical binding]; other site 269799003234 Mg2+ binding site [ion binding]; other site 269799003235 G-X-G motif; other site 269799003236 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799003237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799003238 active site 269799003239 phosphorylation site [posttranslational modification] 269799003240 intermolecular recognition site; other site 269799003241 dimerization interface [polypeptide binding]; other site 269799003242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799003243 Walker A motif; other site 269799003244 ATP binding site [chemical binding]; other site 269799003245 Walker B motif; other site 269799003246 arginine finger; other site 269799003247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799003248 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 269799003249 palindrome; Gmet_R0080 269799003250 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 269799003251 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 269799003252 Type II transport protein GspH; Region: GspH; pfam12019 269799003253 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 269799003254 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 269799003255 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 269799003256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799003257 non-specific DNA binding site [nucleotide binding]; other site 269799003258 salt bridge; other site 269799003259 sequence-specific DNA binding site [nucleotide binding]; other site 269799003260 Competence protein A; Region: Competence_A; pfam11104 269799003261 Cell division protein FtsA; Region: FtsA; cl17206 269799003262 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 269799003263 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 269799003264 Pilus assembly protein, PilO; Region: PilO; pfam04350 269799003265 Pilus assembly protein, PilP; Region: PilP; pfam04351 269799003266 AMIN domain; Region: AMIN; pfam11741 269799003267 AMIN domain; Region: AMIN; pfam11741 269799003268 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 269799003269 Secretin and TonB N terminus short domain; Region: STN; smart00965 269799003270 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 269799003271 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 269799003272 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 269799003273 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 269799003274 Tetramer interface [polypeptide binding]; other site 269799003275 active site 269799003276 FMN-binding site [chemical binding]; other site 269799003277 shikimate kinase; Reviewed; Region: aroK; PRK00131 269799003278 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 269799003279 ADP binding site [chemical binding]; other site 269799003280 magnesium binding site [ion binding]; other site 269799003281 putative shikimate binding site; other site 269799003282 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 269799003283 active site 269799003284 dimer interface [polypeptide binding]; other site 269799003285 metal binding site [ion binding]; metal-binding site 269799003286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799003287 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799003288 TPR motif; other site 269799003289 binding surface 269799003290 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799003291 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 269799003292 Dehydroquinase class II; Region: DHquinase_II; pfam01220 269799003293 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 269799003294 trimer interface [polypeptide binding]; other site 269799003295 active site 269799003296 dimer interface [polypeptide binding]; other site 269799003297 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 269799003298 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 269799003299 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 269799003300 active site 269799003301 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 269799003302 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269799003303 carboxyltransferase (CT) interaction site; other site 269799003304 biotinylation site [posttranslational modification]; other site 269799003305 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 269799003306 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269799003307 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 269799003308 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269799003309 glycine cleavage system protein H; Provisional; Region: PRK13380 269799003310 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 269799003311 lipoyl attachment site [posttranslational modification]; other site 269799003312 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 269799003313 PAS domain S-box; Region: sensory_box; TIGR00229 269799003314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799003315 putative active site [active] 269799003316 heme pocket [chemical binding]; other site 269799003317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799003318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799003319 metal binding site [ion binding]; metal-binding site 269799003320 active site 269799003321 I-site; other site 269799003322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269799003323 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 269799003324 nudix motif; other site 269799003325 conserved nucleotide sequence; Gmet_R0081 269799003326 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 269799003327 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 269799003328 active site 269799003329 substrate binding site [chemical binding]; other site 269799003330 metal binding site [ion binding]; metal-binding site 269799003331 'integration host factor binding site, putative; Gmet_I208A' 269799003332 'integration host factor binding site, putative; Gmet_I208B' 269799003333 conserved nucleotide sequence; Gmet_P0991 269799003334 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 269799003335 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 269799003336 trimerization site [polypeptide binding]; other site 269799003337 active site 269799003338 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 269799003339 NifU-like domain; Region: NifU; cl00484 269799003340 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 269799003341 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 269799003342 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799003343 catalytic residue [active] 269799003344 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 269799003345 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 269799003346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269799003347 ATP binding site [chemical binding]; other site 269799003348 putative Mg++ binding site [ion binding]; other site 269799003349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799003350 nucleotide binding region [chemical binding]; other site 269799003351 ATP-binding site [chemical binding]; other site 269799003352 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269799003353 VacJ like lipoprotein; Region: VacJ; cl01073 269799003354 NMT1-like family; Region: NMT1_2; pfam13379 269799003355 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 269799003356 substrate binding pocket [chemical binding]; other site 269799003357 membrane-bound complex binding site; other site 269799003358 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 269799003359 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 269799003360 Walker A/P-loop; other site 269799003361 ATP binding site [chemical binding]; other site 269799003362 Q-loop/lid; other site 269799003363 ABC transporter signature motif; other site 269799003364 Walker B; other site 269799003365 D-loop; other site 269799003366 H-loop/switch region; other site 269799003367 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 269799003368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799003369 dimer interface [polypeptide binding]; other site 269799003370 conserved gate region; other site 269799003371 putative PBP binding loops; other site 269799003372 ABC-ATPase subunit interface; other site 269799003373 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 269799003374 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 269799003375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 269799003376 motif II; other site 269799003377 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 269799003378 conserved nucleotide sequence; Gmet_P1001 269799003379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799003380 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799003381 conserved nucleotide sequence; Gmet_R2002 269799003382 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 269799003383 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 269799003384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799003385 GAF domain; Region: GAF; pfam01590 269799003386 PAS domain S-box; Region: sensory_box; TIGR00229 269799003387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799003388 putative active site [active] 269799003389 heme pocket [chemical binding]; other site 269799003390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799003391 dimer interface [polypeptide binding]; other site 269799003392 phosphorylation site [posttranslational modification] 269799003393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799003394 ATP binding site [chemical binding]; other site 269799003395 Mg2+ binding site [ion binding]; other site 269799003396 G-X-G motif; other site 269799003397 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 269799003398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799003399 FeS/SAM binding site; other site 269799003400 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 269799003401 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 269799003402 substrate binding site [chemical binding]; other site 269799003403 conserved nucleotide sequence; Gmet_R0082 269799003404 Uncharacterized conserved protein [Function unknown]; Region: COG2128 269799003405 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 269799003406 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 269799003407 Hemerythrin-like domain; Region: Hr-like; cd12108 269799003408 Fe binding site [ion binding]; other site 269799003409 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 269799003410 active site residue [active] 269799003411 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 269799003412 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269799003413 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269799003414 protein binding site [polypeptide binding]; other site 269799003415 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269799003416 protein binding site [polypeptide binding]; other site 269799003417 hypothetical protein; Provisional; Region: PRK10316 269799003418 YfdX protein; Region: YfdX; pfam10938 269799003419 aconitate hydratase; Validated; Region: PRK09277 269799003420 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 269799003421 substrate binding site [chemical binding]; other site 269799003422 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 269799003423 ligand binding site [chemical binding]; other site 269799003424 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 269799003425 substrate binding site [chemical binding]; other site 269799003426 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 269799003427 iron-sulfur cluster [ion binding]; other site 269799003428 [2Fe-2S] cluster binding site [ion binding]; other site 269799003429 Cytochrome c; Region: Cytochrom_C; pfam00034 269799003430 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 269799003431 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 269799003432 [4Fe-4S] binding site [ion binding]; other site 269799003433 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799003434 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799003435 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799003436 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 269799003437 molybdopterin cofactor binding site; other site 269799003438 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 269799003439 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 269799003440 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 269799003441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269799003442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799003443 active site 269799003444 phosphorylation site [posttranslational modification] 269799003445 intermolecular recognition site; other site 269799003446 dimerization interface [polypeptide binding]; other site 269799003447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269799003448 DNA binding site [nucleotide binding] 269799003449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799003450 HAMP domain; Region: HAMP; pfam00672 269799003451 dimerization interface [polypeptide binding]; other site 269799003452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799003453 dimer interface [polypeptide binding]; other site 269799003454 phosphorylation site [posttranslational modification] 269799003455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799003456 ATP binding site [chemical binding]; other site 269799003457 Mg2+ binding site [ion binding]; other site 269799003458 G-X-G motif; other site 269799003459 conserved nucleotide sequence; Gmet_R0083 269799003460 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269799003461 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 269799003462 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 269799003463 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799003464 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799003465 conserved nucleotide sequence; Gmet_P1034 269799003466 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 269799003467 propionate/acetate kinase; Provisional; Region: PRK12379 269799003468 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 269799003469 conserved nucleotide sequence; Gmet_P1035 269799003470 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 269799003471 MPT binding site; other site 269799003472 trimer interface [polypeptide binding]; other site 269799003473 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 269799003474 trimer interface [polypeptide binding]; other site 269799003475 dimer interface [polypeptide binding]; other site 269799003476 putative active site [active] 269799003477 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 269799003478 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 269799003479 dimer interface [polypeptide binding]; other site 269799003480 putative functional site; other site 269799003481 putative MPT binding site; other site 269799003482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799003483 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 269799003484 Walker A/P-loop; other site 269799003485 ATP binding site [chemical binding]; other site 269799003486 Q-loop/lid; other site 269799003487 ABC transporter signature motif; other site 269799003488 Walker B; other site 269799003489 D-loop; other site 269799003490 H-loop/switch region; other site 269799003491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799003492 dimer interface [polypeptide binding]; other site 269799003493 conserved gate region; other site 269799003494 putative PBP binding loops; other site 269799003495 ABC-ATPase subunit interface; other site 269799003496 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 269799003497 PBP superfamily domain; Region: PBP_like_2; pfam12849 269799003498 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 269799003499 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 269799003500 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 269799003501 ATP binding site [chemical binding]; other site 269799003502 substrate interface [chemical binding]; other site 269799003503 ThiS family; Region: ThiS; pfam02597 269799003504 charged pocket; other site 269799003505 hydrophobic patch; other site 269799003506 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 269799003507 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 269799003508 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 269799003509 conserved nucleotide sequence; Gmet_R1014 269799003510 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 269799003511 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 269799003512 dimer interface [polypeptide binding]; other site 269799003513 active site 269799003514 metal binding site [ion binding]; metal-binding site 269799003515 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 269799003516 Predicted ATPase [General function prediction only]; Region: COG5293 269799003517 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 269799003518 Predicted transcriptional regulator [Transcription]; Region: COG4190 269799003519 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 269799003520 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 269799003521 putative active site [active] 269799003522 metal binding site [ion binding]; metal-binding site 269799003523 conserved nucleotide sequence; Gmet_R1015 269799003524 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799003525 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799003526 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269799003527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799003528 dimer interface [polypeptide binding]; other site 269799003529 phosphorylation site [posttranslational modification] 269799003530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799003531 ATP binding site [chemical binding]; other site 269799003532 Mg2+ binding site [ion binding]; other site 269799003533 G-X-G motif; other site 269799003534 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799003535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799003536 active site 269799003537 phosphorylation site [posttranslational modification] 269799003538 intermolecular recognition site; other site 269799003539 dimerization interface [polypeptide binding]; other site 269799003540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799003541 Walker A motif; other site 269799003542 ATP binding site [chemical binding]; other site 269799003543 Walker B motif; other site 269799003544 arginine finger; other site 269799003545 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799003546 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 269799003547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799003548 dimerization interface [polypeptide binding]; other site 269799003549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799003550 dimer interface [polypeptide binding]; other site 269799003551 phosphorylation site [posttranslational modification] 269799003552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799003553 ATP binding site [chemical binding]; other site 269799003554 Mg2+ binding site [ion binding]; other site 269799003555 G-X-G motif; other site 269799003556 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799003557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799003558 active site 269799003559 phosphorylation site [posttranslational modification] 269799003560 intermolecular recognition site; other site 269799003561 dimerization interface [polypeptide binding]; other site 269799003562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799003563 Walker A motif; other site 269799003564 ATP binding site [chemical binding]; other site 269799003565 Walker B motif; other site 269799003566 arginine finger; other site 269799003567 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799003568 conserved nucleotide sequence; Gmet_P1058 269799003569 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 269799003570 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 269799003571 [4Fe-4S] binding site [ion binding]; other site 269799003572 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799003573 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 269799003574 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 269799003575 molybdopterin cofactor binding site; other site 269799003576 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 269799003577 4Fe-4S binding domain; Region: Fer4_6; pfam12837 269799003578 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 269799003579 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 269799003580 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 269799003581 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 269799003582 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 269799003583 GTP binding site; other site 269799003584 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 269799003585 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 269799003586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 269799003587 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 269799003588 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 269799003589 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 269799003590 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 269799003591 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 269799003592 conserved palindrome; Gmet_R5003 269799003593 Transposase IS200 like; Region: Y1_Tnp; cl00848 269799003594 conserved palindrome; Gmet_R5004 269799003595 Transposase domain (DUF772); Region: DUF772; pfam05598 269799003596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799003597 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 269799003598 conserved palindrome; Gmet_R5005 269799003599 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 269799003600 BRO family, N-terminal domain; Region: Bro-N; smart01040 269799003601 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 269799003602 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 269799003603 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 269799003604 putative FMN binding site [chemical binding]; other site 269799003605 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 269799003606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799003607 active site 269799003608 phosphorylation site [posttranslational modification] 269799003609 intermolecular recognition site; other site 269799003610 dimerization interface [polypeptide binding]; other site 269799003611 CheB methylesterase; Region: CheB_methylest; pfam01339 269799003612 CheD chemotactic sensory transduction; Region: CheD; cl00810 269799003613 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 269799003614 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269799003615 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269799003616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 269799003617 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269799003618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799003619 dimerization interface [polypeptide binding]; other site 269799003620 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799003621 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799003622 dimer interface [polypeptide binding]; other site 269799003623 putative CheW interface [polypeptide binding]; other site 269799003624 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 269799003625 putative CheA interaction surface; other site 269799003626 chemotaxis protein CheA; Provisional; Region: PRK10547 269799003627 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269799003628 putative binding surface; other site 269799003629 active site 269799003630 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 269799003631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799003632 ATP binding site [chemical binding]; other site 269799003633 Mg2+ binding site [ion binding]; other site 269799003634 G-X-G motif; other site 269799003635 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 269799003636 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799003637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799003638 active site 269799003639 phosphorylation site [posttranslational modification] 269799003640 intermolecular recognition site; other site 269799003641 dimerization interface [polypeptide binding]; other site 269799003642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799003643 Walker A motif; other site 269799003644 ATP binding site [chemical binding]; other site 269799003645 Walker B motif; other site 269799003646 arginine finger; other site 269799003647 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799003648 PAS domain S-box; Region: sensory_box; TIGR00229 269799003649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799003650 putative active site [active] 269799003651 heme pocket [chemical binding]; other site 269799003652 PAS fold; Region: PAS_4; pfam08448 269799003653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799003654 putative active site [active] 269799003655 heme pocket [chemical binding]; other site 269799003656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799003657 putative active site [active] 269799003658 PAS fold; Region: PAS_3; pfam08447 269799003659 heme pocket [chemical binding]; other site 269799003660 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269799003661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799003662 dimer interface [polypeptide binding]; other site 269799003663 phosphorylation site [posttranslational modification] 269799003664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799003665 ATP binding site [chemical binding]; other site 269799003666 Mg2+ binding site [ion binding]; other site 269799003667 G-X-G motif; other site 269799003668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269799003669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269799003670 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 269799003671 putative dimerization interface [polypeptide binding]; other site 269799003672 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 269799003673 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 269799003674 CPxP motif; other site 269799003675 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 269799003676 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 269799003677 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 269799003678 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 269799003679 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 269799003680 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 269799003681 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 269799003682 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 269799003683 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 269799003684 Cytochrome c; Region: Cytochrom_C; pfam00034 269799003685 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 269799003686 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 269799003687 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 269799003688 hexamer interface [polypeptide binding]; other site 269799003689 ligand binding site [chemical binding]; other site 269799003690 putative active site [active] 269799003691 NAD(P) binding site [chemical binding]; other site 269799003692 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 269799003693 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 269799003694 RNA binding site [nucleotide binding]; other site 269799003695 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 269799003696 RNA binding site [nucleotide binding]; other site 269799003697 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 269799003698 RNA binding site [nucleotide binding]; other site 269799003699 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269799003700 RNA binding site [nucleotide binding]; other site 269799003701 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 269799003702 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 269799003703 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 269799003704 'integration host factor binding site, putative; Gmet_I303A' 269799003705 'integration host factor binding site, putative; Gmet_I303B' 269799003706 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 269799003707 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 269799003708 Substrate binding site; other site 269799003709 Cupin domain; Region: Cupin_2; cl17218 269799003710 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 269799003711 putative cation:proton antiport protein; Provisional; Region: PRK10669 269799003712 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 269799003713 TrkA-N domain; Region: TrkA_N; pfam02254 269799003714 TrkA-C domain; Region: TrkA_C; pfam02080 269799003715 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 269799003716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799003717 Zn2+ binding site [ion binding]; other site 269799003718 Mg2+ binding site [ion binding]; other site 269799003719 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 269799003720 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 269799003721 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 269799003722 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 269799003723 putative dimer interface [polypeptide binding]; other site 269799003724 [2Fe-2S] cluster binding site [ion binding]; other site 269799003725 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 269799003726 dimer interface [polypeptide binding]; other site 269799003727 [2Fe-2S] cluster binding site [ion binding]; other site 269799003728 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 269799003729 SLBB domain; Region: SLBB; pfam10531 269799003730 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 269799003731 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 269799003732 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799003733 catalytic loop [active] 269799003734 iron binding site [ion binding]; other site 269799003735 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 269799003736 4Fe-4S binding domain; Region: Fer4; cl02805 269799003737 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 269799003738 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 269799003739 transposase/IS protein; Provisional; Region: PRK09183 269799003740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799003741 Walker A motif; other site 269799003742 ATP binding site [chemical binding]; other site 269799003743 Walker B motif; other site 269799003744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 269799003745 Integrase core domain; Region: rve; pfam00665 269799003746 Transcriptional regulators [Transcription]; Region: GntR; COG1802 269799003747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 269799003748 DNA-binding site [nucleotide binding]; DNA binding site 269799003749 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 269799003750 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 269799003751 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 269799003752 tetramer interface [polypeptide binding]; other site 269799003753 active site 269799003754 Mg2+/Mn2+ binding site [ion binding]; other site 269799003755 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 269799003756 2-methylcitrate dehydratase; Region: prpD; TIGR02330 269799003757 type I citrate synthase; Reviewed; Region: PRK09569 269799003758 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 269799003759 oxalacetate binding site [chemical binding]; other site 269799003760 citrylCoA binding site [chemical binding]; other site 269799003761 coenzyme A binding site [chemical binding]; other site 269799003762 catalytic triad [active] 269799003763 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269799003764 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 269799003765 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269799003766 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 269799003767 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 269799003768 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 269799003769 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 269799003770 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 269799003771 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 269799003772 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 269799003773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799003774 Walker A motif; other site 269799003775 ATP binding site [chemical binding]; other site 269799003776 Walker B motif; other site 269799003777 arginine finger; other site 269799003778 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 269799003779 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 269799003780 conserved nucleotide sequence; Gmet_R1016 269799003781 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 269799003782 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 269799003783 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 269799003784 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 269799003785 'integration host factor binding site, putative; Gmet_I113A' 269799003786 'integration host factor binding site, putative; Gmet_I113B' 269799003787 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799003788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799003789 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799003790 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 269799003791 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 269799003792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799003793 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 269799003794 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 269799003795 dimerization domain [polypeptide binding]; other site 269799003796 dimer interface [polypeptide binding]; other site 269799003797 catalytic residues [active] 269799003798 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 269799003799 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 269799003800 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 269799003801 Domain of unknown function DUF21; Region: DUF21; pfam01595 269799003802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 269799003803 Transporter associated domain; Region: CorC_HlyC; smart01091 269799003804 Domain of unknown function DUF20; Region: UPF0118; pfam01594 269799003805 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 269799003806 conserved palindrome; Gmet_R5006 269799003807 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 269799003808 Peptidase family M48; Region: Peptidase_M48; cl12018 269799003809 conserved nucleotide sequence; Gmet_R0086 269799003810 Predicted membrane protein [Function unknown]; Region: COG2119 269799003811 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 269799003812 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 269799003813 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 269799003814 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 269799003815 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 269799003816 active site 269799003817 tetramer interface; other site 269799003818 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 269799003819 FAD binding site [chemical binding]; other site 269799003820 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 269799003821 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 269799003822 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 269799003823 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 269799003824 homodimer interface [polypeptide binding]; other site 269799003825 NADP binding site [chemical binding]; other site 269799003826 substrate binding site [chemical binding]; other site 269799003827 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 269799003828 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 269799003829 DivIVA protein; Region: DivIVA; pfam05103 269799003830 DivIVA domain; Region: DivI1A_domain; TIGR03544 269799003831 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 269799003832 YGGT family; Region: YGGT; pfam02325 269799003833 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 269799003834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799003835 S-adenosylmethionine binding site [chemical binding]; other site 269799003836 Uncharacterized conserved protein [Function unknown]; Region: COG1624 269799003837 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 269799003838 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799003839 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 269799003840 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799003841 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 269799003842 NlpC/P60 family; Region: NLPC_P60; pfam00877 269799003843 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 269799003844 active site 269799003845 8-oxo-dGMP binding site [chemical binding]; other site 269799003846 nudix motif; other site 269799003847 metal binding site [ion binding]; metal-binding site 269799003848 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 269799003849 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799003850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799003851 FeS/SAM binding site; other site 269799003852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799003853 binding surface 269799003854 TPR repeat; Region: TPR_11; pfam13414 269799003855 TPR motif; other site 269799003856 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799003857 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 269799003858 TIGR02099 family protein; Region: TIGR02099 269799003859 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 269799003860 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 269799003861 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 269799003862 Walker A/P-loop; other site 269799003863 ATP binding site [chemical binding]; other site 269799003864 Q-loop/lid; other site 269799003865 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 269799003866 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 269799003867 ABC transporter signature motif; other site 269799003868 Walker B; other site 269799003869 D-loop; other site 269799003870 H-loop/switch region; other site 269799003871 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 269799003872 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 269799003873 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 269799003874 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 269799003875 P loop; other site 269799003876 GTP binding site [chemical binding]; other site 269799003877 Protein of unknown function (DUF904); Region: DUF904; pfam06005 269799003878 Cell division protein ZapA; Region: ZapA; pfam05164 269799003879 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 269799003880 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 269799003881 phosphodiesterase; Provisional; Region: PRK12704 269799003882 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799003883 Zn2+ binding site [ion binding]; other site 269799003884 Mg2+ binding site [ion binding]; other site 269799003885 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 269799003886 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 269799003887 putative active site [active] 269799003888 metal binding site [ion binding]; metal-binding site 269799003889 homodimer binding site [polypeptide binding]; other site 269799003890 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 269799003891 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 269799003892 active site 269799003893 HIGH motif; other site 269799003894 dimer interface [polypeptide binding]; other site 269799003895 KMSKS motif; other site 269799003896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269799003897 RNA binding surface [nucleotide binding]; other site 269799003898 putative transposase OrfB; Reviewed; Region: PHA02517 269799003899 HTH-like domain; Region: HTH_21; pfam13276 269799003900 Integrase core domain; Region: rve; pfam00665 269799003901 Integrase core domain; Region: rve_3; pfam13683 269799003902 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 269799003903 DNA-binding interface [nucleotide binding]; DNA binding site 269799003904 Winged helix-turn helix; Region: HTH_29; pfam13551 269799003905 glutamate dehydrogenase; Provisional; Region: PRK09414 269799003906 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 269799003907 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 269799003908 NAD(P) binding site [chemical binding]; other site 269799003909 conserved nucleotide sequence; Gmet_P1187 269799003910 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 269799003911 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 269799003912 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 269799003913 oligomer interface [polypeptide binding]; other site 269799003914 metal binding site [ion binding]; metal-binding site 269799003915 metal binding site [ion binding]; metal-binding site 269799003916 Cl binding site [ion binding]; other site 269799003917 aspartate ring; other site 269799003918 basic sphincter; other site 269799003919 putative hydrophobic gate; other site 269799003920 periplasmic entrance; other site 269799003921 Outer membrane efflux protein; Region: OEP; pfam02321 269799003922 Outer membrane efflux protein; Region: OEP; pfam02321 269799003923 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 269799003924 conserved nucleotide sequence; Gmet_P1194 269799003925 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 269799003926 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 269799003927 catalytic triad [active] 269799003928 putative active site [active] 269799003929 TIR domain; Region: TIR_2; pfam13676 269799003930 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 269799003931 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 269799003932 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 269799003933 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 269799003934 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 269799003935 Putative serine esterase (DUF676); Region: DUF676; pfam05057 269799003936 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 269799003937 CHAT domain; Region: CHAT; pfam12770 269799003938 TIR domain; Region: TIR_2; pfam13676 269799003939 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799003940 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 269799003941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799003942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799003943 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799003944 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799003945 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799003946 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 269799003947 LrgB-like family; Region: LrgB; pfam04172 269799003948 LrgA family; Region: LrgA; pfam03788 269799003949 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 269799003950 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 269799003951 DNA binding site [nucleotide binding] 269799003952 putative catalytic residues [active] 269799003953 turnover-facilitating residue; other site 269799003954 intercalation triad [nucleotide binding]; other site 269799003955 8OG recognition residue [nucleotide binding]; other site 269799003956 putative reading head residues; other site 269799003957 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 269799003958 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 269799003959 Clostripain family; Region: Peptidase_C11; pfam03415 269799003960 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 269799003961 conserved nucleotide sequence; Gmet_R7002 269799003962 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 269799003963 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 269799003964 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 269799003965 palindrome; Gmet_R0087 269799003966 PAS domain S-box; Region: sensory_box; TIGR00229 269799003967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799003968 putative active site [active] 269799003969 heme pocket [chemical binding]; other site 269799003970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799003971 dimer interface [polypeptide binding]; other site 269799003972 phosphorylation site [posttranslational modification] 269799003973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799003974 ATP binding site [chemical binding]; other site 269799003975 Mg2+ binding site [ion binding]; other site 269799003976 G-X-G motif; other site 269799003977 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 269799003978 AAA ATPase domain; Region: AAA_16; pfam13191 269799003979 NACHT domain; Region: NACHT; pfam05729 269799003980 Walker A motif; other site 269799003981 ATP binding site [chemical binding]; other site 269799003982 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 269799003983 structural tetrad; other site 269799003984 FOG: WD40 repeat [General function prediction only]; Region: COG2319 269799003985 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 269799003986 structural tetrad; other site 269799003987 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 269799003988 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 269799003989 active site 269799003990 PHP Thumb interface [polypeptide binding]; other site 269799003991 metal binding site [ion binding]; metal-binding site 269799003992 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 269799003993 generic binding surface II; other site 269799003994 generic binding surface I; other site 269799003995 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 269799003996 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 269799003997 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 269799003998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269799003999 RNA binding surface [nucleotide binding]; other site 269799004000 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 269799004001 active site 269799004002 PAS domain S-box; Region: sensory_box; TIGR00229 269799004003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799004004 putative active site [active] 269799004005 heme pocket [chemical binding]; other site 269799004006 PAS fold; Region: PAS_4; pfam08448 269799004007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799004008 putative active site [active] 269799004009 heme pocket [chemical binding]; other site 269799004010 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269799004011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799004012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799004013 dimer interface [polypeptide binding]; other site 269799004014 phosphorylation site [posttranslational modification] 269799004015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799004016 ATP binding site [chemical binding]; other site 269799004017 Mg2+ binding site [ion binding]; other site 269799004018 G-X-G motif; other site 269799004019 Response regulator receiver domain; Region: Response_reg; pfam00072 269799004020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799004021 active site 269799004022 phosphorylation site [posttranslational modification] 269799004023 intermolecular recognition site; other site 269799004024 dimerization interface [polypeptide binding]; other site 269799004025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799004026 dimer interface [polypeptide binding]; other site 269799004027 phosphorylation site [posttranslational modification] 269799004028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799004029 ATP binding site [chemical binding]; other site 269799004030 Mg2+ binding site [ion binding]; other site 269799004031 G-X-G motif; other site 269799004032 Response regulator receiver domain; Region: Response_reg; pfam00072 269799004033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799004034 active site 269799004035 phosphorylation site [posttranslational modification] 269799004036 intermolecular recognition site; other site 269799004037 dimerization interface [polypeptide binding]; other site 269799004038 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269799004039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799004040 sequence-specific DNA binding site [nucleotide binding]; other site 269799004041 salt bridge; other site 269799004042 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 269799004043 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269799004044 RNA binding surface [nucleotide binding]; other site 269799004045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799004046 S-adenosylmethionine binding site [chemical binding]; other site 269799004047 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 269799004048 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 269799004049 active site 269799004050 metal binding site [ion binding]; metal-binding site 269799004051 DNA binding site [nucleotide binding] 269799004052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799004053 ABC transporter signature motif; other site 269799004054 Walker B; other site 269799004055 D-loop; other site 269799004056 H-loop/switch region; other site 269799004057 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 269799004058 nucleotide binding site/active site [active] 269799004059 HIT family signature motif; other site 269799004060 catalytic residue [active] 269799004061 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 269799004062 conserved nucleotide sequence; Gmet_R0088 269799004063 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 269799004064 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 269799004065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799004066 ATP binding site [chemical binding]; other site 269799004067 Mg2+ binding site [ion binding]; other site 269799004068 G-X-G motif; other site 269799004069 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 269799004070 anti sigma factor interaction site; other site 269799004071 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 269799004072 regulatory phosphorylation site [posttranslational modification]; other site 269799004073 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 269799004074 Na binding site [ion binding]; other site 269799004075 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 269799004076 GAF domain; Region: GAF_2; pfam13185 269799004077 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799004078 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 269799004079 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 269799004080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 269799004081 Predicted kinase [General function prediction only]; Region: COG0645 269799004082 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 269799004083 active site 269799004084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004085 binding surface 269799004086 TPR motif; other site 269799004087 TPR repeat; Region: TPR_11; pfam13414 269799004088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004089 TPR motif; other site 269799004090 binding surface 269799004091 TPR repeat; Region: TPR_11; pfam13414 269799004092 Tetratricopeptide repeat; Region: TPR_12; pfam13424 269799004093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004094 binding surface 269799004095 TPR motif; other site 269799004096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004097 binding surface 269799004098 TPR motif; other site 269799004099 TPR repeat; Region: TPR_11; pfam13414 269799004100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004101 binding surface 269799004102 TPR motif; other site 269799004103 TPR repeat; Region: TPR_11; pfam13414 269799004104 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 269799004105 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 269799004106 peptide binding site [polypeptide binding]; other site 269799004107 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 269799004108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799004109 dimer interface [polypeptide binding]; other site 269799004110 conserved gate region; other site 269799004111 putative PBP binding loops; other site 269799004112 ABC-ATPase subunit interface; other site 269799004113 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 269799004114 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 269799004115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799004116 dimer interface [polypeptide binding]; other site 269799004117 conserved gate region; other site 269799004118 putative PBP binding loops; other site 269799004119 ABC-ATPase subunit interface; other site 269799004120 Peptidase family M48; Region: Peptidase_M48; pfam01435 269799004121 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 269799004122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799004123 Walker A motif; other site 269799004124 ATP binding site [chemical binding]; other site 269799004125 Walker B motif; other site 269799004126 conserved nucleotide sequence; Gmet_R0089 269799004127 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456 269799004128 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799004129 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799004130 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 269799004131 active site clefts [active] 269799004132 zinc binding site [ion binding]; other site 269799004133 dimer interface [polypeptide binding]; other site 269799004134 sensor protein ZraS; Provisional; Region: PRK10364 269799004135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799004136 dimerization interface [polypeptide binding]; other site 269799004137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799004138 dimer interface [polypeptide binding]; other site 269799004139 phosphorylation site [posttranslational modification] 269799004140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799004141 ATP binding site [chemical binding]; other site 269799004142 Mg2+ binding site [ion binding]; other site 269799004143 G-X-G motif; other site 269799004144 Response regulator receiver domain; Region: Response_reg; pfam00072 269799004145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799004146 active site 269799004147 phosphorylation site [posttranslational modification] 269799004148 intermolecular recognition site; other site 269799004149 dimerization interface [polypeptide binding]; other site 269799004150 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 269799004151 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 269799004152 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269799004153 N-terminal plug; other site 269799004154 ligand-binding site [chemical binding]; other site 269799004155 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 269799004156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799004157 FeS/SAM binding site; other site 269799004158 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 269799004159 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 269799004160 IPT/TIG domain; Region: TIG; pfam01833 269799004161 Predicted permeases [General function prediction only]; Region: COG0795 269799004162 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 269799004163 Predicted permeases [General function prediction only]; Region: COG0795 269799004164 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 269799004165 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 269799004166 rRNA interaction site [nucleotide binding]; other site 269799004167 S8 interaction site; other site 269799004168 putative laminin-1 binding site; other site 269799004169 elongation factor Ts; Reviewed; Region: tsf; PRK12332 269799004170 UBA/TS-N domain; Region: UBA; pfam00627 269799004171 Elongation factor TS; Region: EF_TS; pfam00889 269799004172 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 269799004173 putative nucleotide binding site [chemical binding]; other site 269799004174 uridine monophosphate binding site [chemical binding]; other site 269799004175 homohexameric interface [polypeptide binding]; other site 269799004176 ribosome recycling factor; Reviewed; Region: frr; PRK00083 269799004177 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 269799004178 hinge region; other site 269799004179 conserved nucleotide sequence; Gmet_P1254 269799004180 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 269799004181 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 269799004182 catalytic residue [active] 269799004183 putative FPP diphosphate binding site; other site 269799004184 putative FPP binding hydrophobic cleft; other site 269799004185 dimer interface [polypeptide binding]; other site 269799004186 putative IPP diphosphate binding site; other site 269799004187 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 269799004188 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 269799004189 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 269799004190 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 269799004191 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 269799004192 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 269799004193 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 269799004194 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 269799004195 active site 269799004196 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 269799004197 protein binding site [polypeptide binding]; other site 269799004198 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 269799004199 putative substrate binding region [chemical binding]; other site 269799004200 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 269799004201 Glycoprotease family; Region: Peptidase_M22; pfam00814 269799004202 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 269799004203 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 269799004204 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 269799004205 PYR/PP interface [polypeptide binding]; other site 269799004206 dimer interface [polypeptide binding]; other site 269799004207 TPP binding site [chemical binding]; other site 269799004208 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 269799004209 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 269799004210 TPP-binding site [chemical binding]; other site 269799004211 dimer interface [polypeptide binding]; other site 269799004212 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 269799004213 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 269799004214 putative valine binding site [chemical binding]; other site 269799004215 dimer interface [polypeptide binding]; other site 269799004216 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 269799004217 ketol-acid reductoisomerase; Provisional; Region: PRK05479 269799004218 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 269799004219 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 269799004220 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 269799004221 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 269799004222 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 269799004223 2-isopropylmalate synthase; Validated; Region: PRK00915 269799004224 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 269799004225 active site 269799004226 catalytic residues [active] 269799004227 metal binding site [ion binding]; metal-binding site 269799004228 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 269799004229 palindrome; Gmet_R0090 269799004230 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269799004231 DNA-binding site [nucleotide binding]; DNA binding site 269799004232 RNA-binding motif; other site 269799004233 conserved nucleotide sequence; Gmet_P1266 269799004234 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 269799004235 conserved nucleotide sequence; Gmet_P1268 269799004236 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 269799004237 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 269799004238 substrate binding site [chemical binding]; other site 269799004239 ligand binding site [chemical binding]; other site 269799004240 3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171 269799004241 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 269799004242 substrate binding site [chemical binding]; other site 269799004243 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 269799004244 Permease; Region: Permease; pfam02405 269799004245 mce related protein; Region: MCE; pfam02470 269799004246 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 269799004247 Protein of unknown function (DUF422); Region: DUF422; cl00991 269799004248 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 269799004249 conserved nucleotide sequence; Gmet_P1274 269799004250 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 269799004251 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 269799004252 Ligand binding site; other site 269799004253 oligomer interface; other site 269799004254 CTP synthetase; Validated; Region: pyrG; PRK05380 269799004255 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 269799004256 Catalytic site [active] 269799004257 active site 269799004258 UTP binding site [chemical binding]; other site 269799004259 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 269799004260 active site 269799004261 putative oxyanion hole; other site 269799004262 catalytic triad [active] 269799004263 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 269799004264 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 269799004265 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 269799004266 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 269799004267 putative active site [active] 269799004268 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 269799004269 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 269799004270 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 269799004271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 269799004272 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 269799004273 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 269799004274 OstA-like protein; Region: OstA; pfam03968 269799004275 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 269799004276 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 269799004277 Walker A/P-loop; other site 269799004278 ATP binding site [chemical binding]; other site 269799004279 Q-loop/lid; other site 269799004280 ABC transporter signature motif; other site 269799004281 Walker B; other site 269799004282 D-loop; other site 269799004283 H-loop/switch region; other site 269799004284 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 269799004285 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 269799004286 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 269799004287 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 269799004288 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 269799004289 30S subunit binding site; other site 269799004290 HPr kinase/phosphorylase; Provisional; Region: PRK05428 269799004291 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 269799004292 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 269799004293 Hpr binding site; other site 269799004294 active site 269799004295 homohexamer subunit interaction site [polypeptide binding]; other site 269799004296 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 269799004297 AAA domain; Region: AAA_33; pfam13671 269799004298 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 269799004299 active pocket/dimerization site; other site 269799004300 active site 269799004301 phosphorylation site [posttranslational modification] 269799004302 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 269799004303 dimerization domain swap beta strand [polypeptide binding]; other site 269799004304 regulatory protein interface [polypeptide binding]; other site 269799004305 active site 269799004306 regulatory phosphorylation site [posttranslational modification]; other site 269799004307 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 269799004308 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 269799004309 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269799004310 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269799004311 S-adenosylmethionine synthetase; Validated; Region: PRK05250 269799004312 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 269799004313 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 269799004314 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 269799004315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269799004316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799004317 active site 269799004318 phosphorylation site [posttranslational modification] 269799004319 intermolecular recognition site; other site 269799004320 dimerization interface [polypeptide binding]; other site 269799004321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269799004322 DNA binding site [nucleotide binding] 269799004323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799004324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799004325 dimer interface [polypeptide binding]; other site 269799004326 phosphorylation site [posttranslational modification] 269799004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799004328 ATP binding site [chemical binding]; other site 269799004329 Mg2+ binding site [ion binding]; other site 269799004330 G-X-G motif; other site 269799004331 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 269799004332 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 269799004333 FMN binding site [chemical binding]; other site 269799004334 substrate binding site [chemical binding]; other site 269799004335 putative catalytic residue [active] 269799004336 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 269799004337 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 269799004338 homotetramer interface [polypeptide binding]; other site 269799004339 ligand binding site [chemical binding]; other site 269799004340 catalytic site [active] 269799004341 NAD binding site [chemical binding]; other site 269799004342 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 269799004343 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 269799004344 active site 269799004345 Zn binding site [ion binding]; other site 269799004346 Smr domain; Region: Smr; pfam01713 269799004347 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 269799004348 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 269799004349 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 269799004350 active site 269799004351 dimer interface [polypeptide binding]; other site 269799004352 effector binding site; other site 269799004353 TSCPD domain; Region: TSCPD; pfam12637 269799004354 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799004355 GAF domain; Region: GAF; pfam01590 269799004356 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799004357 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799004358 metal binding site [ion binding]; metal-binding site 269799004359 active site 269799004360 I-site; other site 269799004361 Right handed beta helix region; Region: Beta_helix; pfam13229 269799004362 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 269799004363 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 269799004364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799004365 catalytic residue [active] 269799004366 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 269799004367 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 269799004368 putative active site [active] 269799004369 PhoH-like protein; Region: PhoH; pfam02562 269799004370 UGMP family protein; Validated; Region: PRK09604 269799004371 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 269799004372 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 269799004373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799004374 S-adenosylmethionine binding site [chemical binding]; other site 269799004375 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 269799004376 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799004377 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799004378 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 269799004379 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269799004380 dimer interface [polypeptide binding]; other site 269799004381 PYR/PP interface [polypeptide binding]; other site 269799004382 TPP binding site [chemical binding]; other site 269799004383 substrate binding site [chemical binding]; other site 269799004384 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 269799004385 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 269799004386 TPP-binding site [chemical binding]; other site 269799004387 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 269799004388 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 269799004389 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799004390 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799004391 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 269799004392 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 269799004393 NADP-binding site; other site 269799004394 homotetramer interface [polypeptide binding]; other site 269799004395 substrate binding site [chemical binding]; other site 269799004396 homodimer interface [polypeptide binding]; other site 269799004397 active site 269799004398 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 269799004399 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 269799004400 NADP binding site [chemical binding]; other site 269799004401 active site 269799004402 putative substrate binding site [chemical binding]; other site 269799004403 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 269799004404 metal binding triad [ion binding]; metal-binding site 269799004405 Protein of unknown function DUF86; Region: DUF86; pfam01934 269799004406 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799004407 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799004408 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799004409 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 269799004410 active site 269799004411 NTP binding site [chemical binding]; other site 269799004412 metal binding triad [ion binding]; metal-binding site 269799004413 antibiotic binding site [chemical binding]; other site 269799004414 Protein of unknown function DUF86; Region: DUF86; pfam01934 269799004415 conserved nucleotide sequence; Gmet_R8001 269799004416 conserved nucleotide sequence; Gmet_R8002 269799004417 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 269799004418 active site 269799004419 NTP binding site [chemical binding]; other site 269799004420 metal binding triad [ion binding]; metal-binding site 269799004421 antibiotic binding site [chemical binding]; other site 269799004422 conserved nucleotide sequence; Gmet_R8003 269799004423 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 269799004424 YcfA-like protein; Region: YcfA; pfam07927 269799004425 conserved nucleotide sequence; Gmet_R8004 269799004426 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 269799004427 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 269799004428 putative trimer interface [polypeptide binding]; other site 269799004429 putative active site [active] 269799004430 putative substrate binding site [chemical binding]; other site 269799004431 putative CoA binding site [chemical binding]; other site 269799004432 WxcM-like, C-terminal; Region: FdtA; pfam05523 269799004433 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 269799004434 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 269799004435 inhibitor-cofactor binding pocket; inhibition site 269799004436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799004437 catalytic residue [active] 269799004438 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 269799004439 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 269799004440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004441 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269799004442 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 269799004443 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 269799004444 GDP-Fucose binding site [chemical binding]; other site 269799004445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269799004446 active site 269799004447 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004448 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269799004449 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269799004450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799004451 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799004452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269799004453 active site 269799004454 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269799004455 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 269799004456 putative NAD(P) binding site [chemical binding]; other site 269799004457 active site 269799004458 putative substrate binding site [chemical binding]; other site 269799004459 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 269799004460 AAA domain; Region: AAA_14; pfam13173 269799004461 Bacterial sugar transferase; Region: Bac_transf; pfam02397 269799004462 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 269799004463 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 269799004464 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 269799004465 NAD(P) binding site [chemical binding]; other site 269799004466 homodimer interface [polypeptide binding]; other site 269799004467 substrate binding site [chemical binding]; other site 269799004468 active site 269799004469 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 269799004470 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 269799004471 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 269799004472 putative active site [active] 269799004473 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 269799004474 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 269799004475 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269799004476 Beta-Casp domain; Region: Beta-Casp; smart01027 269799004477 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 269799004478 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 269799004479 SLBB domain; Region: SLBB; pfam10531 269799004480 SLBB domain; Region: SLBB; pfam10531 269799004481 SLBB domain; Region: SLBB; pfam10531 269799004482 SLBB domain; Region: SLBB; pfam10531 269799004483 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 269799004484 Chain length determinant protein; Region: Wzz; pfam02706 269799004485 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 269799004486 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 269799004487 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 269799004488 active site 269799004489 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 269799004490 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 269799004491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799004492 motif II; other site 269799004493 octanucleotide repeats; Gmet_R0153 269799004494 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 269799004495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269799004496 ATP binding site [chemical binding]; other site 269799004497 putative Mg++ binding site [ion binding]; other site 269799004498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799004499 nucleotide binding region [chemical binding]; other site 269799004500 ATP-binding site [chemical binding]; other site 269799004501 Helicase associated domain (HA2); Region: HA2; pfam04408 269799004502 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 269799004503 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 269799004504 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269799004505 Peptidase family M23; Region: Peptidase_M23; pfam01551 269799004506 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 269799004507 Nitrogen regulatory protein P-II; Region: P-II; smart00938 269799004508 glutamine synthetase, type I; Region: GlnA; TIGR00653 269799004509 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 269799004510 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 269799004511 conserved palindrome; Gmet_R0091 269799004512 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 269799004513 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 269799004514 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 269799004515 prolyl-tRNA synthetase; Provisional; Region: PRK09194 269799004516 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 269799004517 dimer interface [polypeptide binding]; other site 269799004518 motif 1; other site 269799004519 active site 269799004520 motif 2; other site 269799004521 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 269799004522 putative deacylase active site [active] 269799004523 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 269799004524 active site 269799004525 motif 3; other site 269799004526 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 269799004527 anticodon binding site; other site 269799004528 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 269799004529 active site 269799004530 dimer interface [polypeptide binding]; other site 269799004531 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 269799004532 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 269799004533 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 269799004534 conserved nucleotide sequence; Gmet_R0092 269799004535 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 269799004536 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 269799004537 dimer interface [polypeptide binding]; other site 269799004538 anticodon binding site; other site 269799004539 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 269799004540 homodimer interface [polypeptide binding]; other site 269799004541 motif 1; other site 269799004542 active site 269799004543 motif 2; other site 269799004544 GAD domain; Region: GAD; pfam02938 269799004545 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 269799004546 motif 3; other site 269799004547 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799004548 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 269799004549 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 269799004550 malate dehydrogenase; Reviewed; Region: PRK06223 269799004551 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 269799004552 NAD(P) binding site [chemical binding]; other site 269799004553 dimer interface [polypeptide binding]; other site 269799004554 tetramer (dimer of dimers) interface [polypeptide binding]; other site 269799004555 substrate binding site [chemical binding]; other site 269799004556 conserved palindrome; Gmet_R0093 269799004557 conserved nucleotide sequence; Gmet_P1361 269799004558 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799004559 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 269799004560 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 269799004561 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269799004562 dimer interface [polypeptide binding]; other site 269799004563 PYR/PP interface [polypeptide binding]; other site 269799004564 TPP binding site [chemical binding]; other site 269799004565 substrate binding site [chemical binding]; other site 269799004566 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269799004567 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 269799004568 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 269799004569 TPP-binding site [chemical binding]; other site 269799004570 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 269799004571 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 269799004572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799004573 Zn2+ binding site [ion binding]; other site 269799004574 Mg2+ binding site [ion binding]; other site 269799004575 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 269799004576 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 269799004577 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 269799004578 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 269799004579 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 269799004580 Uncharacterized conserved protein [Function unknown]; Region: COG4095 269799004581 LemA family; Region: LemA; pfam04011 269799004582 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 269799004583 Repair protein; Region: Repair_PSII; pfam04536 269799004584 Repair protein; Region: Repair_PSII; cl01535 269799004585 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 269799004586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799004587 putative substrate translocation pore; other site 269799004588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799004589 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 269799004590 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269799004591 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799004592 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 269799004593 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 269799004594 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 269799004595 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269799004596 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269799004597 catalytic residue [active] 269799004598 Response regulator receiver domain; Region: Response_reg; pfam00072 269799004599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799004600 active site 269799004601 phosphorylation site [posttranslational modification] 269799004602 intermolecular recognition site; other site 269799004603 dimerization interface [polypeptide binding]; other site 269799004604 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 269799004605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799004606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799004607 ATP binding site [chemical binding]; other site 269799004608 Mg2+ binding site [ion binding]; other site 269799004609 G-X-G motif; other site 269799004610 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 269799004611 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 269799004612 catalytic residues [active] 269799004613 hinge region; other site 269799004614 alpha helical domain; other site 269799004615 putative disulfide oxidoreductase; Provisional; Region: PRK04307 269799004616 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 269799004617 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 269799004618 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269799004619 catalytic residues [active] 269799004620 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 269799004621 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 269799004622 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 269799004623 ribonuclease R; Region: RNase_R; TIGR02063 269799004624 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 269799004625 RNA binding site [nucleotide binding]; other site 269799004626 RNB domain; Region: RNB; pfam00773 269799004627 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 269799004628 RNA binding site [nucleotide binding]; other site 269799004629 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 269799004630 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 269799004631 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 269799004632 active site 269799004633 Riboflavin kinase; Region: Flavokinase; pfam01687 269799004634 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 269799004635 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799004636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799004637 S-adenosylmethionine binding site [chemical binding]; other site 269799004638 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 269799004639 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 269799004640 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 269799004641 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 269799004642 shikimate binding site; other site 269799004643 NAD(P) binding site [chemical binding]; other site 269799004644 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 269799004645 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269799004646 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 269799004647 Walker A motif; other site 269799004648 ATP binding site [chemical binding]; other site 269799004649 Walker B motif; other site 269799004650 conserved nucleotide sequence; Gmet_P1394 269799004651 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 269799004652 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 269799004653 Walker A motif; other site 269799004654 ATP binding site [chemical binding]; other site 269799004655 Walker B motif; other site 269799004656 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 269799004657 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 269799004658 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 269799004659 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269799004660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799004661 putative active site [active] 269799004662 heme pocket [chemical binding]; other site 269799004663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799004664 dimer interface [polypeptide binding]; other site 269799004665 phosphorylation site [posttranslational modification] 269799004666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799004667 ATP binding site [chemical binding]; other site 269799004668 Mg2+ binding site [ion binding]; other site 269799004669 G-X-G motif; other site 269799004670 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799004671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799004672 active site 269799004673 phosphorylation site [posttranslational modification] 269799004674 intermolecular recognition site; other site 269799004675 dimerization interface [polypeptide binding]; other site 269799004676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799004677 Walker A motif; other site 269799004678 ATP binding site [chemical binding]; other site 269799004679 Walker B motif; other site 269799004680 arginine finger; other site 269799004681 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799004682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799004683 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799004684 conserved nucleotide sequence; Gmet_P1399 269799004685 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 269799004686 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269799004687 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 269799004688 Walker A/P-loop; other site 269799004689 ATP binding site [chemical binding]; other site 269799004690 Q-loop/lid; other site 269799004691 ABC transporter signature motif; other site 269799004692 Walker B; other site 269799004693 D-loop; other site 269799004694 H-loop/switch region; other site 269799004695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 269799004696 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 269799004697 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 269799004698 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 269799004699 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 269799004700 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 269799004701 Walker A/P-loop; other site 269799004702 ATP binding site [chemical binding]; other site 269799004703 Q-loop/lid; other site 269799004704 ABC transporter signature motif; other site 269799004705 Walker B; other site 269799004706 D-loop; other site 269799004707 H-loop/switch region; other site 269799004708 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799004709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004710 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 269799004711 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269799004712 putative active site [active] 269799004713 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 269799004714 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 269799004715 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 269799004716 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 269799004717 active site 269799004718 dimer interface [polypeptide binding]; other site 269799004719 motif 1; other site 269799004720 motif 2; other site 269799004721 motif 3; other site 269799004722 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 269799004723 anticodon binding site; other site 269799004724 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 269799004725 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 269799004726 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 269799004727 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 269799004728 conserved nucleotide sequence; Gmet_P1414 269799004729 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 269799004730 23S rRNA binding site [nucleotide binding]; other site 269799004731 L21 binding site [polypeptide binding]; other site 269799004732 L13 binding site [polypeptide binding]; other site 269799004733 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 269799004734 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 269799004735 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 269799004736 dimer interface [polypeptide binding]; other site 269799004737 motif 1; other site 269799004738 active site 269799004739 motif 2; other site 269799004740 motif 3; other site 269799004741 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 269799004742 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 269799004743 putative tRNA-binding site [nucleotide binding]; other site 269799004744 B3/4 domain; Region: B3_4; pfam03483 269799004745 tRNA synthetase B5 domain; Region: B5; smart00874 269799004746 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 269799004747 dimer interface [polypeptide binding]; other site 269799004748 motif 1; other site 269799004749 motif 3; other site 269799004750 motif 2; other site 269799004751 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 269799004752 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269799004753 IHF - DNA interface [nucleotide binding]; other site 269799004754 IHF dimer interface [polypeptide binding]; other site 269799004755 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 269799004756 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 269799004757 DNA binding residues [nucleotide binding] 269799004758 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 269799004759 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 269799004760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799004761 S-adenosylmethionine binding site [chemical binding]; other site 269799004762 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 269799004763 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 269799004764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269799004765 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 269799004766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269799004767 DNA binding residues [nucleotide binding] 269799004768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269799004769 active site 269799004770 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 269799004771 MutS domain I; Region: MutS_I; pfam01624 269799004772 MutS domain II; Region: MutS_II; pfam05188 269799004773 MutS domain III; Region: MutS_III; pfam05192 269799004774 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 269799004775 Walker A/P-loop; other site 269799004776 ATP binding site [chemical binding]; other site 269799004777 Q-loop/lid; other site 269799004778 ABC transporter signature motif; other site 269799004779 Walker B; other site 269799004780 D-loop; other site 269799004781 H-loop/switch region; other site 269799004782 AMIN domain; Region: AMIN; pfam11741 269799004783 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 269799004784 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 269799004785 active site 269799004786 metal binding site [ion binding]; metal-binding site 269799004787 PII uridylyl-transferase; Provisional; Region: PRK05092 269799004788 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269799004789 metal binding triad; other site 269799004790 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 269799004791 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 269799004792 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 269799004793 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 269799004794 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 269799004795 active site 269799004796 Int/Topo IB signature motif; other site 269799004797 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 269799004798 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 269799004799 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 269799004800 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 269799004801 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 269799004802 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 269799004803 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 269799004804 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 269799004805 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269799004806 NAD binding site [chemical binding]; other site 269799004807 putative substrate binding site 2 [chemical binding]; other site 269799004808 putative substrate binding site 1 [chemical binding]; other site 269799004809 active site 269799004810 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 269799004811 Septum formation initiator; Region: DivIC; pfam04977 269799004812 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 269799004813 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 269799004814 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 269799004815 active site 269799004816 HIGH motif; other site 269799004817 KMSK motif region; other site 269799004818 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 269799004819 tRNA binding surface [nucleotide binding]; other site 269799004820 anticodon binding site; other site 269799004821 Sporulation related domain; Region: SPOR; pfam05036 269799004822 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 269799004823 GIY-YIG motif/motif A; other site 269799004824 putative active site [active] 269799004825 putative metal binding site [ion binding]; other site 269799004826 LexA repressor; Validated; Region: PRK00215 269799004827 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 269799004828 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 269799004829 Catalytic site [active] 269799004830 DNA polymerase IV; Reviewed; Region: PRK03103 269799004831 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 269799004832 active site 269799004833 DNA binding site [nucleotide binding] 269799004834 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 269799004835 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 269799004836 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 269799004837 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 269799004838 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 269799004839 SLBB domain; Region: SLBB; pfam10531 269799004840 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 269799004841 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 269799004842 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 269799004843 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799004844 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 269799004845 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 269799004846 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 269799004847 active site 269799004848 catalytic residues [active] 269799004849 PBP superfamily domain; Region: PBP_like_2; cl17296 269799004850 PEP-CTERM motif; Region: VPEP; pfam07589 269799004851 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269799004852 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 269799004853 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269799004854 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 269799004855 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 269799004856 Surface antigen; Region: Bac_surface_Ag; pfam01103 269799004857 haemagglutination activity domain; Region: Haemagg_act; smart00912 269799004858 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 269799004859 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 269799004860 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 269799004861 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 269799004862 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 269799004863 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 269799004864 TonB C terminal; Region: TonB_2; pfam13103 269799004865 Competence protein CoiA-like family; Region: CoiA; cl11541 269799004866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799004867 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 269799004868 M28 Zn-Peptidases; Region: M28_like_1; cd05640 269799004869 Peptidase family M28; Region: Peptidase_M28; pfam04389 269799004870 metal binding site [ion binding]; metal-binding site 269799004871 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 269799004872 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 269799004873 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799004874 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 269799004875 acyl-activating enzyme (AAE) consensus motif; other site 269799004876 putative AMP binding site [chemical binding]; other site 269799004877 putative active site [active] 269799004878 putative CoA binding site [chemical binding]; other site 269799004879 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 269799004880 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 269799004881 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 269799004882 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 269799004883 ski2-like helicase; Provisional; Region: PRK02362 269799004884 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 269799004885 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 269799004886 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 269799004887 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 269799004888 RHS Repeat; Region: RHS_repeat; pfam05593 269799004889 RHS Repeat; Region: RHS_repeat; pfam05593 269799004890 RHS Repeat; Region: RHS_repeat; pfam05593 269799004891 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 269799004892 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 269799004893 GH3 auxin-responsive promoter; Region: GH3; pfam03321 269799004894 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 269799004895 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 269799004896 active site 269799004897 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 269799004898 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004899 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 269799004900 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 269799004901 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 269799004902 NAD binding site [chemical binding]; other site 269799004903 homodimer interface [polypeptide binding]; other site 269799004904 active site 269799004905 substrate binding site [chemical binding]; other site 269799004906 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 269799004907 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 269799004908 glutaminase active site [active] 269799004909 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 269799004910 dimer interface [polypeptide binding]; other site 269799004911 active site 269799004912 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 269799004913 dimer interface [polypeptide binding]; other site 269799004914 active site 269799004915 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 269799004916 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 269799004917 NADP-binding site; other site 269799004918 homotetramer interface [polypeptide binding]; other site 269799004919 substrate binding site [chemical binding]; other site 269799004920 homodimer interface [polypeptide binding]; other site 269799004921 active site 269799004922 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 269799004923 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 269799004924 active site 269799004925 homodimer interface [polypeptide binding]; other site 269799004926 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 269799004927 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_epsE_like; cd13129 269799004928 Methyltransferase domain; Region: Methyltransf_24; pfam13578 269799004929 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004930 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799004931 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269799004932 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 269799004933 metal-binding site 269799004934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004935 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269799004936 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004937 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799004938 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269799004939 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 269799004940 active site 269799004941 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004942 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 269799004943 putative ADP-binding pocket [chemical binding]; other site 269799004944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799004945 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799004946 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 269799004947 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 269799004948 putative glycosyl transferase; Provisional; Region: PRK10307 269799004949 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 269799004950 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 269799004951 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 269799004952 EpsI family protein; Region: EpsI_fam; TIGR02914 269799004953 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 269799004954 active site 269799004955 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 269799004956 homodimer interface [polypeptide binding]; other site 269799004957 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 269799004958 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 269799004959 Mg++ binding site [ion binding]; other site 269799004960 putative catalytic motif [active] 269799004961 substrate binding site [chemical binding]; other site 269799004962 FAR1 DNA-binding domain; Region: FAR1; pfam03101 269799004963 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 269799004964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004965 binding surface 269799004966 TPR motif; other site 269799004967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004968 binding surface 269799004969 TPR motif; other site 269799004970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004971 binding surface 269799004972 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799004973 TPR motif; other site 269799004974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004975 binding surface 269799004976 TPR motif; other site 269799004977 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269799004978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004979 binding surface 269799004980 TPR motif; other site 269799004981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799004982 binding surface 269799004983 TPR motif; other site 269799004984 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 269799004985 Beta-lactamase; Region: Beta-lactamase; pfam00144 269799004986 Flavodoxin domain; Region: Flavodoxin_5; cl17428 269799004987 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799004988 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 269799004989 putative deacylase active site [active] 269799004990 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 269799004991 active site 1 [active] 269799004992 dimer interface [polypeptide binding]; other site 269799004993 hexamer interface [polypeptide binding]; other site 269799004994 active site 2 [active] 269799004995 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 269799004996 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269799004997 transcriptional regulator EpsA; Region: EpsA; TIGR03020 269799004998 Autoinducer binding domain; Region: Autoind_bind; pfam03472 269799004999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269799005000 DNA binding residues [nucleotide binding] 269799005001 dimerization interface [polypeptide binding]; other site 269799005002 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269799005003 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269799005004 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 269799005005 FtsX-like permease family; Region: FtsX; pfam02687 269799005006 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269799005007 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269799005008 Walker A/P-loop; other site 269799005009 ATP binding site [chemical binding]; other site 269799005010 Q-loop/lid; other site 269799005011 ABC transporter signature motif; other site 269799005012 Walker B; other site 269799005013 D-loop; other site 269799005014 H-loop/switch region; other site 269799005015 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 269799005016 ABC1 family; Region: ABC1; pfam03109 269799005017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799005018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799005019 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 269799005020 CoA-transferase family III; Region: CoA_transf_3; pfam02515 269799005021 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 269799005022 CoA-transferase family III; Region: CoA_transf_3; pfam02515 269799005023 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799005024 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 269799005025 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 269799005026 active site 269799005027 enoyl-CoA hydratase; Provisional; Region: PRK06494 269799005028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799005029 substrate binding site [chemical binding]; other site 269799005030 oxyanion hole (OAH) forming residues; other site 269799005031 trimer interface [polypeptide binding]; other site 269799005032 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799005033 Ligand binding site [chemical binding]; other site 269799005034 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799005035 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 269799005036 Ligand Binding Site [chemical binding]; other site 269799005037 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799005038 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799005039 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799005040 Cysteine-rich domain; Region: CCG; pfam02754 269799005041 Cysteine-rich domain; Region: CCG; pfam02754 269799005042 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 269799005043 DUF35 OB-fold domain; Region: DUF35; pfam01796 269799005044 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 269799005045 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 269799005046 active site 269799005047 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269799005048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799005049 NAD(P) binding site [chemical binding]; other site 269799005050 active site 269799005051 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269799005052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799005053 NAD(P) binding site [chemical binding]; other site 269799005054 active site 269799005055 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 269799005056 ligand binding site [chemical binding]; other site 269799005057 flexible hinge region; other site 269799005058 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 269799005059 L-aspartate oxidase; Provisional; Region: PRK06175 269799005060 Predicted oxidoreductase [General function prediction only]; Region: COG3573 269799005061 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 269799005062 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 269799005063 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 269799005064 metal ion-dependent adhesion site (MIDAS); other site 269799005065 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 269799005066 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 269799005067 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 269799005068 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 269799005069 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 269799005070 BssC/TutF protein; Region: BssC_TutF; pfam08201 269799005071 [benzylsuccinate synthase]-activating enzyme; Region: rSAM_BssD; TIGR04003 269799005072 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 269799005073 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799005074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005075 FeS/SAM binding site; other site 269799005076 Activator of aromatic catabolism; Region: XylR_N; pfam06505 269799005077 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 269799005078 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 269799005079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799005080 Walker A motif; other site 269799005081 ATP binding site [chemical binding]; other site 269799005082 Walker B motif; other site 269799005083 arginine finger; other site 269799005084 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799005085 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 269799005086 Cytochrome C' Region: Cytochrom_C_2; cl01610 269799005087 Sporulation and spore germination; Region: Germane; pfam10646 269799005088 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 269799005089 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 269799005090 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799005091 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 269799005092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799005093 Response regulator receiver domain; Region: Response_reg; pfam00072 269799005094 active site 269799005095 phosphorylation site [posttranslational modification] 269799005096 intermolecular recognition site; other site 269799005097 dimerization interface [polypeptide binding]; other site 269799005098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269799005099 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269799005100 Walker A/P-loop; other site 269799005101 ATP binding site [chemical binding]; other site 269799005102 Q-loop/lid; other site 269799005103 ABC transporter signature motif; other site 269799005104 Walker B; other site 269799005105 D-loop; other site 269799005106 H-loop/switch region; other site 269799005107 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 269799005108 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269799005109 FtsX-like permease family; Region: FtsX; pfam02687 269799005110 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 269799005111 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269799005112 metal-binding site [ion binding] 269799005113 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269799005114 metal-binding site [ion binding] 269799005115 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 269799005116 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 269799005117 dimer interface [polypeptide binding]; other site 269799005118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799005119 catalytic residue [active] 269799005120 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269799005121 Peptidase family M23; Region: Peptidase_M23; pfam01551 269799005122 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 269799005123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799005124 Zn2+ binding site [ion binding]; other site 269799005125 Mg2+ binding site [ion binding]; other site 269799005126 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 269799005127 conserved nucleotide sequence fragment; Gmet_P3650 269799005128 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 269799005129 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269799005130 homodimer interface [polypeptide binding]; other site 269799005131 substrate-cofactor binding pocket; other site 269799005132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799005133 catalytic residue [active] 269799005134 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 269799005135 thiS-thiF/thiG interaction site; other site 269799005136 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 269799005137 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 269799005138 ATP binding site [chemical binding]; other site 269799005139 substrate interface [chemical binding]; other site 269799005140 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 269799005141 MPN+ (JAMM) motif; other site 269799005142 Zinc-binding site [ion binding]; other site 269799005143 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 269799005144 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 269799005145 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799005146 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 269799005147 CPxP motif; other site 269799005148 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 269799005149 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799005150 substrate binding site [chemical binding]; other site 269799005151 oxyanion hole (OAH) forming residues; other site 269799005152 trimer interface [polypeptide binding]; other site 269799005153 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 269799005154 homodimer interface [polypeptide binding]; other site 269799005155 Walker A motif; other site 269799005156 ATP binding site [chemical binding]; other site 269799005157 hydroxycobalamin binding site [chemical binding]; other site 269799005158 Walker B motif; other site 269799005159 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 269799005160 B12 binding site [chemical binding]; other site 269799005161 cobalt ligand [ion binding]; other site 269799005162 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 269799005163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799005164 substrate binding site [chemical binding]; other site 269799005165 oxyanion hole (OAH) forming residues; other site 269799005166 trimer interface [polypeptide binding]; other site 269799005167 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 269799005168 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 269799005169 Walker A; other site 269799005170 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 269799005171 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 269799005172 DHH family; Region: DHH; pfam01368 269799005173 FOG: CBS domain [General function prediction only]; Region: COG0517 269799005174 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 269799005175 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 269799005176 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 269799005177 active site 269799005178 NTP binding site [chemical binding]; other site 269799005179 metal binding triad [ion binding]; metal-binding site 269799005180 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 269799005181 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 269799005182 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 269799005183 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269799005184 inhibitor-cofactor binding pocket; inhibition site 269799005185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799005186 catalytic residue [active] 269799005187 AAA domain; Region: AAA_26; pfam13500 269799005188 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 269799005189 biotin synthase; Region: bioB; TIGR00433 269799005190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005191 FeS/SAM binding site; other site 269799005192 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 269799005193 ribosome maturation protein RimP; Reviewed; Region: PRK00092 269799005194 Sm and related proteins; Region: Sm_like; cl00259 269799005195 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 269799005196 putative oligomer interface [polypeptide binding]; other site 269799005197 putative RNA binding site [nucleotide binding]; other site 269799005198 NusA N-terminal domain; Region: NusA_N; pfam08529 269799005199 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 269799005200 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 269799005201 RNA binding site [nucleotide binding]; other site 269799005202 homodimer interface [polypeptide binding]; other site 269799005203 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 269799005204 G-X-X-G motif; other site 269799005205 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 269799005206 G-X-X-G motif; other site 269799005207 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 269799005208 putative RNA binding cleft [nucleotide binding]; other site 269799005209 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 269799005210 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 269799005211 translation initiation factor IF-2; Validated; Region: infB; PRK05306 269799005212 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 269799005213 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 269799005214 G1 box; other site 269799005215 putative GEF interaction site [polypeptide binding]; other site 269799005216 GTP/Mg2+ binding site [chemical binding]; other site 269799005217 Switch I region; other site 269799005218 G2 box; other site 269799005219 G3 box; other site 269799005220 Switch II region; other site 269799005221 G4 box; other site 269799005222 G5 box; other site 269799005223 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 269799005224 Translation-initiation factor 2; Region: IF-2; pfam11987 269799005225 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 269799005226 ribosome-binding factor A; Provisional; Region: PRK13815 269799005227 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 269799005228 DHH family; Region: DHH; pfam01368 269799005229 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 269799005230 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 269799005231 RNA binding site [nucleotide binding]; other site 269799005232 active site 269799005233 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 269799005234 16S/18S rRNA binding site [nucleotide binding]; other site 269799005235 S13e-L30e interaction site [polypeptide binding]; other site 269799005236 25S rRNA binding site [nucleotide binding]; other site 269799005237 conserved nucleotide sequence; Gmet_R0151 269799005238 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 269799005239 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 269799005240 RNase E interface [polypeptide binding]; other site 269799005241 trimer interface [polypeptide binding]; other site 269799005242 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 269799005243 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 269799005244 RNase E interface [polypeptide binding]; other site 269799005245 trimer interface [polypeptide binding]; other site 269799005246 active site 269799005247 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 269799005248 putative nucleic acid binding region [nucleotide binding]; other site 269799005249 G-X-X-G motif; other site 269799005250 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 269799005251 RNA binding site [nucleotide binding]; other site 269799005252 domain interface; other site 269799005253 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269799005254 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269799005255 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269799005256 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 269799005257 trimer interface [polypeptide binding]; other site 269799005258 active site 269799005259 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 269799005260 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 269799005261 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 269799005262 conserved nucleotide sequence; Gmet_P1596 269799005263 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 269799005264 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 269799005265 putative phosphate acyltransferase; Provisional; Region: PRK05331 269799005266 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 269799005267 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 269799005268 dimer interface [polypeptide binding]; other site 269799005269 active site 269799005270 CoA binding pocket [chemical binding]; other site 269799005271 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 269799005272 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 269799005273 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 269799005274 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 269799005275 NAD(P) binding site [chemical binding]; other site 269799005276 homotetramer interface [polypeptide binding]; other site 269799005277 homodimer interface [polypeptide binding]; other site 269799005278 active site 269799005279 acyl carrier protein; Provisional; Region: acpP; PRK00982 269799005280 conserved palindrome; Gmet_P1603 269799005281 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 269799005282 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 269799005283 dimer interface [polypeptide binding]; other site 269799005284 active site 269799005285 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 269799005286 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 269799005287 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 269799005288 dimer interface [polypeptide binding]; other site 269799005289 active site 269799005290 glycine-pyridoxal phosphate binding site [chemical binding]; other site 269799005291 folate binding site [chemical binding]; other site 269799005292 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 269799005293 Response regulator receiver domain; Region: Response_reg; pfam00072 269799005294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799005295 active site 269799005296 phosphorylation site [posttranslational modification] 269799005297 intermolecular recognition site; other site 269799005298 dimerization interface [polypeptide binding]; other site 269799005299 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269799005300 IHF dimer interface [polypeptide binding]; other site 269799005301 IHF - DNA interface [nucleotide binding]; other site 269799005302 conserved nucleotide sequence; Gmet_R0094 269799005303 TSCPD domain; Region: TSCPD; pfam12637 269799005304 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 269799005305 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799005306 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799005307 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 269799005308 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 269799005309 acyl-activating enzyme (AAE) consensus motif; other site 269799005310 putative AMP binding site [chemical binding]; other site 269799005311 putative active site [active] 269799005312 putative CoA binding site [chemical binding]; other site 269799005313 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 269799005314 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 269799005315 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 269799005316 putative acyl-acceptor binding pocket; other site 269799005317 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 269799005318 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 269799005319 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269799005320 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 269799005321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799005322 motif II; other site 269799005323 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 269799005324 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 269799005325 AAA domain; Region: AAA_26; pfam13500 269799005326 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 269799005327 DRTGG domain; Region: DRTGG; pfam07085 269799005328 Protein of unknown function (DUF327); Region: DUF327; pfam03885 269799005329 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 269799005330 hypothetical protein; Reviewed; Region: PRK09588 269799005331 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799005332 Zn2+ binding site [ion binding]; other site 269799005333 Mg2+ binding site [ion binding]; other site 269799005334 RF-1 domain; Region: RF-1; pfam00472 269799005335 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 269799005336 catalytic motif [active] 269799005337 Zn binding site [ion binding]; other site 269799005338 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 269799005339 ATP cone domain; Region: ATP-cone; pfam03477 269799005340 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 269799005341 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 269799005342 catalytic motif [active] 269799005343 Zn binding site [ion binding]; other site 269799005344 RibD C-terminal domain; Region: RibD_C; cl17279 269799005345 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 269799005346 Lumazine binding domain; Region: Lum_binding; pfam00677 269799005347 Lumazine binding domain; Region: Lum_binding; pfam00677 269799005348 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 269799005349 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 269799005350 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 269799005351 dimerization interface [polypeptide binding]; other site 269799005352 active site 269799005353 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 269799005354 homopentamer interface [polypeptide binding]; other site 269799005355 active site 269799005356 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 269799005357 putative RNA binding site [nucleotide binding]; other site 269799005358 homoserine dehydrogenase; Provisional; Region: PRK06349 269799005359 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 269799005360 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 269799005361 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 269799005362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 269799005363 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 269799005364 motif II; other site 269799005365 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 269799005366 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 269799005367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799005368 catalytic residue [active] 269799005369 MoxR-like ATPases [General function prediction only]; Region: COG0714 269799005370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 269799005371 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 269799005372 Protein of unknown function DUF58; Region: DUF58; pfam01882 269799005373 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 269799005374 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 269799005375 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 269799005376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799005377 TPR motif; other site 269799005378 binding surface 269799005379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799005380 TPR motif; other site 269799005381 binding surface 269799005382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799005383 binding surface 269799005384 TPR motif; other site 269799005385 Tetratricopeptide repeat; Region: TPR_12; pfam13424 269799005386 TonB C terminal; Region: TonB_2; pfam13103 269799005387 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 269799005388 Malic enzyme, N-terminal domain; Region: malic; pfam00390 269799005389 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 269799005390 putative NAD(P) binding site [chemical binding]; other site 269799005391 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 269799005392 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 269799005393 nucleotide binding site/active site [active] 269799005394 HIT family signature motif; other site 269799005395 catalytic residue [active] 269799005396 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 269799005397 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 269799005398 nucleotide binding site [chemical binding]; other site 269799005399 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 269799005400 phosphofructokinase; Region: PFK_mixed; TIGR02483 269799005401 active site 269799005402 ADP/pyrophosphate binding site [chemical binding]; other site 269799005403 dimerization interface [polypeptide binding]; other site 269799005404 allosteric effector site; other site 269799005405 fructose-1,6-bisphosphate binding site; other site 269799005406 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799005407 GAF domain; Region: GAF; pfam01590 269799005408 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799005409 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799005410 dimer interface [polypeptide binding]; other site 269799005411 putative CheW interface [polypeptide binding]; other site 269799005412 conserved nucleotide sequence; Gmet_P1642 269799005413 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 269799005414 oligomerization interface [polypeptide binding]; other site 269799005415 active site 269799005416 metal binding site [ion binding]; metal-binding site 269799005417 pantoate--beta-alanine ligase; Region: panC; TIGR00018 269799005418 Pantoate-beta-alanine ligase; Region: PanC; cd00560 269799005419 active site 269799005420 ATP-binding site [chemical binding]; other site 269799005421 pantoate-binding site; other site 269799005422 HXXH motif; other site 269799005423 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 269799005424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799005425 catalytic residue [active] 269799005426 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 269799005427 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 269799005428 active site 269799005429 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 269799005430 SmpB-tmRNA interface; other site 269799005431 conserved nucleotide sequence; Gmet_R0095 269799005432 palindrome; Gmet_R0096 269799005433 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 269799005434 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 269799005435 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269799005436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269799005437 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799005438 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 269799005439 Protein export membrane protein; Region: SecD_SecF; cl14618 269799005440 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 269799005441 catalytic core [active] 269799005442 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 269799005443 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 269799005444 endonuclease III; Region: ENDO3c; smart00478 269799005445 minor groove reading motif; other site 269799005446 helix-hairpin-helix signature motif; other site 269799005447 substrate binding pocket [chemical binding]; other site 269799005448 active site 269799005449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269799005450 putative DNA binding site [nucleotide binding]; other site 269799005451 putative Zn2+ binding site [ion binding]; other site 269799005452 CoA binding domain; Region: CoA_binding_2; pfam13380 269799005453 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 269799005454 active site 269799005455 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 269799005456 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 269799005457 Creatinine amidohydrolase; Region: Creatininase; pfam02633 269799005458 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 269799005459 RES domain; Region: RES; smart00953 269799005460 Uncharacterized conserved protein [Function unknown]; Region: COG1359 269799005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799005462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269799005463 putative substrate translocation pore; other site 269799005464 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 269799005465 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269799005466 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269799005467 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 269799005468 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 269799005469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799005470 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799005471 dimerization interface [polypeptide binding]; other site 269799005472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799005473 dimer interface [polypeptide binding]; other site 269799005474 phosphorylation site [posttranslational modification] 269799005475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799005476 ATP binding site [chemical binding]; other site 269799005477 Mg2+ binding site [ion binding]; other site 269799005478 G-X-G motif; other site 269799005479 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 269799005480 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 269799005481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269799005482 N-terminal plug; other site 269799005483 ligand-binding site [chemical binding]; other site 269799005484 Response regulator receiver domain; Region: Response_reg; pfam00072 269799005485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799005486 active site 269799005487 phosphorylation site [posttranslational modification] 269799005488 intermolecular recognition site; other site 269799005489 dimerization interface [polypeptide binding]; other site 269799005490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799005491 dimer interface [polypeptide binding]; other site 269799005492 phosphorylation site [posttranslational modification] 269799005493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799005494 ATP binding site [chemical binding]; other site 269799005495 Mg2+ binding site [ion binding]; other site 269799005496 G-X-G motif; other site 269799005497 Transglycosylase; Region: Transgly; pfam00912 269799005498 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 269799005499 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 269799005500 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 269799005501 CoenzymeA binding site [chemical binding]; other site 269799005502 subunit interaction site [polypeptide binding]; other site 269799005503 PHB binding site; other site 269799005504 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 269799005505 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 269799005506 glycerol kinase; Provisional; Region: glpK; PRK00047 269799005507 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 269799005508 N- and C-terminal domain interface [polypeptide binding]; other site 269799005509 active site 269799005510 MgATP binding site [chemical binding]; other site 269799005511 catalytic site [active] 269799005512 metal binding site [ion binding]; metal-binding site 269799005513 glycerol binding site [chemical binding]; other site 269799005514 homotetramer interface [polypeptide binding]; other site 269799005515 homodimer interface [polypeptide binding]; other site 269799005516 FBP binding site [chemical binding]; other site 269799005517 protein IIAGlc interface [polypeptide binding]; other site 269799005518 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 269799005519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 269799005520 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 269799005521 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 269799005522 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 269799005523 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269799005524 Peptidase family M23; Region: Peptidase_M23; pfam01551 269799005525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799005526 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 269799005527 putative substrate translocation pore; other site 269799005528 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799005529 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799005530 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799005531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 269799005532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 269799005533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 269799005534 dimerization interface [polypeptide binding]; other site 269799005535 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 269799005536 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 269799005537 putative active site [active] 269799005538 putative catalytic site [active] 269799005539 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269799005540 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 269799005541 Ligand binding site; other site 269799005542 Putative Catalytic site; other site 269799005543 DXD motif; other site 269799005544 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 269799005545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005546 FeS/SAM binding site; other site 269799005547 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 269799005548 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 269799005549 putative acyl-acceptor binding pocket; other site 269799005550 Phosphopantetheine attachment site; Region: PP-binding; cl09936 269799005551 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 269799005552 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799005553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005554 FeS/SAM binding site; other site 269799005555 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 269799005556 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 269799005557 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269799005558 active site 269799005559 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 269799005560 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 269799005561 B12 binding site [chemical binding]; other site 269799005562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005563 FeS/SAM binding site; other site 269799005564 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 269799005565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799005566 NAD(P) binding site [chemical binding]; other site 269799005567 active site 269799005568 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 269799005569 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 269799005570 dimer interface [polypeptide binding]; other site 269799005571 active site 269799005572 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 269799005573 active site 269799005574 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 269799005575 active site 1 [active] 269799005576 active site 2 [active] 269799005577 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 269799005578 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 269799005579 Predicted exporter [General function prediction only]; Region: COG4258 269799005580 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799005581 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 269799005582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005583 FeS/SAM binding site; other site 269799005584 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799005585 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 269799005586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005587 FeS/SAM binding site; other site 269799005588 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 269799005589 conserved nucleotide sequence; Gmet_R0097 269799005590 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799005591 palindrome; Gmet_R0098 269799005592 conserved nucleotide sequence; Gmet_R0099 269799005593 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 269799005594 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799005595 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 269799005596 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005597 FeS/SAM binding site; other site 269799005598 Response regulator receiver domain; Region: Response_reg; pfam00072 269799005599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799005600 active site 269799005601 phosphorylation site [posttranslational modification] 269799005602 intermolecular recognition site; other site 269799005603 dimerization interface [polypeptide binding]; other site 269799005604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799005605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799005606 metal binding site [ion binding]; metal-binding site 269799005607 active site 269799005608 I-site; other site 269799005609 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 269799005610 PAS domain S-box; Region: sensory_box; TIGR00229 269799005611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799005612 putative active site [active] 269799005613 heme pocket [chemical binding]; other site 269799005614 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269799005615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799005616 putative active site [active] 269799005617 heme pocket [chemical binding]; other site 269799005618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799005619 dimer interface [polypeptide binding]; other site 269799005620 phosphorylation site [posttranslational modification] 269799005621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799005622 ATP binding site [chemical binding]; other site 269799005623 Mg2+ binding site [ion binding]; other site 269799005624 G-X-G motif; other site 269799005625 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799005626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799005627 active site 269799005628 phosphorylation site [posttranslational modification] 269799005629 intermolecular recognition site; other site 269799005630 dimerization interface [polypeptide binding]; other site 269799005631 Hpt domain; Region: Hpt; pfam01627 269799005632 Coenzyme A transferase; Region: CoA_trans; cl17247 269799005633 Coenzyme A transferase; Region: CoA_trans; smart00882 269799005634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799005635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269799005636 active site 269799005637 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 269799005638 CoA-transferase family III; Region: CoA_transf_3; pfam02515 269799005639 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799005640 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269799005641 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799005642 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799005643 Ligand binding site [chemical binding]; other site 269799005644 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799005645 conserved nucleotide sequence; Gmet_R1017 269799005646 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 269799005647 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799005648 4Fe-4S binding domain; Region: Fer4; cl02805 269799005649 Cysteine-rich domain; Region: CCG; pfam02754 269799005650 Cysteine-rich domain; Region: CCG; pfam02754 269799005651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799005652 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 269799005653 FAD binding site [chemical binding]; other site 269799005654 homotetramer interface [polypeptide binding]; other site 269799005655 substrate binding pocket [chemical binding]; other site 269799005656 catalytic base [active] 269799005657 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 269799005658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799005659 substrate binding site [chemical binding]; other site 269799005660 oxyanion hole (OAH) forming residues; other site 269799005661 trimer interface [polypeptide binding]; other site 269799005662 conserved nucleotide sequence; Gmet_R6003 269799005663 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 269799005664 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 269799005665 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 269799005666 'integration host factor binding site, putative; Gmet_I114A' 269799005667 'integration host factor binding site, putative; Gmet_I114B' 269799005668 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799005669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799005670 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799005671 putative acyltransferase; Provisional; Region: PRK05790 269799005672 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269799005673 dimer interface [polypeptide binding]; other site 269799005674 active site 269799005675 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 269799005676 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 269799005677 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 269799005678 active site 269799005679 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 269799005680 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 269799005681 conserved nucleotide sequence; Gmet_R1018 269799005682 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 269799005683 B12 binding site [chemical binding]; other site 269799005684 cobalt ligand [ion binding]; other site 269799005685 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 269799005686 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799005687 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 269799005688 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 269799005689 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 269799005690 DNA binding residues [nucleotide binding] 269799005691 dimer interface [polypeptide binding]; other site 269799005692 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 269799005693 YaeQ protein; Region: YaeQ; pfam07152 269799005694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 269799005695 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 269799005696 active site 269799005697 catalytic tetrad [active] 269799005698 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799005699 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 269799005700 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 269799005701 palindrome; Gmet_R0100 269799005702 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269799005703 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 269799005704 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269799005705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799005706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799005707 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 269799005708 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269799005709 active site 269799005710 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 269799005711 active site 2 [active] 269799005712 active site 1 [active] 269799005713 Methyltransferase domain; Region: Methyltransf_31; pfam13847 269799005714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799005715 S-adenosylmethionine binding site [chemical binding]; other site 269799005716 Domain of unknown function (DUF329); Region: DUF329; pfam03884 269799005717 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 269799005718 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 269799005719 HIGH motif; other site 269799005720 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 269799005721 active site 269799005722 KMSKS motif; other site 269799005723 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269799005724 Response regulator receiver domain; Region: Response_reg; pfam00072 269799005725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799005726 active site 269799005727 phosphorylation site [posttranslational modification] 269799005728 intermolecular recognition site; other site 269799005729 dimerization interface [polypeptide binding]; other site 269799005730 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 269799005731 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 269799005732 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 269799005733 active site 269799005734 Zn binding site [ion binding]; other site 269799005735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 269799005736 binding surface 269799005737 TPR motif; other site 269799005738 conserved nucleotide sequence; Gmet_R0101 269799005739 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 269799005740 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 269799005741 Walker A/P-loop; other site 269799005742 ATP binding site [chemical binding]; other site 269799005743 Q-loop/lid; other site 269799005744 ABC transporter signature motif; other site 269799005745 Walker B; other site 269799005746 D-loop; other site 269799005747 H-loop/switch region; other site 269799005748 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799005749 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 269799005750 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 269799005751 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 269799005752 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 269799005753 zinc binding site [ion binding]; other site 269799005754 putative ligand binding site [chemical binding]; other site 269799005755 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269799005756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799005757 active site 269799005758 phosphorylation site [posttranslational modification] 269799005759 intermolecular recognition site; other site 269799005760 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 269799005761 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 269799005762 active site 269799005763 metal binding site [ion binding]; metal-binding site 269799005764 homotetramer interface [polypeptide binding]; other site 269799005765 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 269799005766 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 269799005767 oligomer interface [polypeptide binding]; other site 269799005768 tandem repeat interface [polypeptide binding]; other site 269799005769 active site residues [active] 269799005770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 269799005771 Peptidase M15; Region: Peptidase_M15_3; cl01194 269799005772 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 269799005773 putative subunit interface; other site 269799005774 four heptanucleotide repeats; Gmet_H421 269799005775 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 269799005776 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 269799005777 putative active site [active] 269799005778 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 269799005779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799005780 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799005781 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 269799005782 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 269799005783 4Fe-4S binding domain; Region: Fer4; pfam00037 269799005784 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 269799005785 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 269799005786 active site 269799005787 FMN binding site [chemical binding]; other site 269799005788 substrate binding site [chemical binding]; other site 269799005789 3Fe-4S cluster binding site [ion binding]; other site 269799005790 PilZ domain; Region: PilZ; pfam07238 269799005791 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 269799005792 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 269799005793 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 269799005794 active site 269799005795 (T/H)XGH motif; other site 269799005796 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 269799005797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799005798 S-adenosylmethionine binding site [chemical binding]; other site 269799005799 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 269799005800 intersubunit interface [polypeptide binding]; other site 269799005801 active site 269799005802 zinc binding site [ion binding]; other site 269799005803 Na+ binding site [ion binding]; other site 269799005804 conserved nucleotide sequence; Gmet_R0102 269799005805 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 269799005806 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799005807 Zn2+ binding site [ion binding]; other site 269799005808 Mg2+ binding site [ion binding]; other site 269799005809 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 269799005810 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 269799005811 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 269799005812 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 269799005813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799005814 ATP binding site [chemical binding]; other site 269799005815 Mg2+ binding site [ion binding]; other site 269799005816 G-X-G motif; other site 269799005817 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799005818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799005819 active site 269799005820 phosphorylation site [posttranslational modification] 269799005821 intermolecular recognition site; other site 269799005822 dimerization interface [polypeptide binding]; other site 269799005823 GTP-binding protein LepA; Provisional; Region: PRK05433 269799005824 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 269799005825 G1 box; other site 269799005826 putative GEF interaction site [polypeptide binding]; other site 269799005827 GTP/Mg2+ binding site [chemical binding]; other site 269799005828 Switch I region; other site 269799005829 G2 box; other site 269799005830 G3 box; other site 269799005831 Switch II region; other site 269799005832 G4 box; other site 269799005833 G5 box; other site 269799005834 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 269799005835 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 269799005836 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 269799005837 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 269799005838 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 269799005839 Catalytic site [active] 269799005840 conserved nucleotide sequence; Gmet_P1768 269799005841 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 269799005842 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269799005843 active site 269799005844 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 269799005845 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 269799005846 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 269799005847 dihydroorotase; Validated; Region: pyrC; PRK09357 269799005848 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269799005849 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 269799005850 active site 269799005851 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 269799005852 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 269799005853 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 269799005854 catalytic site [active] 269799005855 subunit interface [polypeptide binding]; other site 269799005856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005857 FeS/SAM binding site; other site 269799005858 Protein of unknown function, DUF486; Region: DUF486; cl01236 269799005859 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 269799005860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269799005861 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 269799005862 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 269799005863 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269799005864 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269799005865 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 269799005866 IMP binding site; other site 269799005867 dimer interface [polypeptide binding]; other site 269799005868 partial ornithine binding site; other site 269799005869 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 269799005870 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 269799005871 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 269799005872 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 269799005873 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 269799005874 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 269799005875 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 269799005876 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 269799005877 generic binding surface II; other site 269799005878 ssDNA binding site; other site 269799005879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269799005880 ATP binding site [chemical binding]; other site 269799005881 putative Mg++ binding site [ion binding]; other site 269799005882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799005883 nucleotide binding region [chemical binding]; other site 269799005884 ATP-binding site [chemical binding]; other site 269799005885 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 269799005886 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 269799005887 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269799005888 catalytic residues [active] 269799005889 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 269799005890 active site 269799005891 HIGH motif; other site 269799005892 nucleotide binding site [chemical binding]; other site 269799005893 active site 269799005894 KMSKS motif; other site 269799005895 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 269799005896 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 269799005897 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 269799005898 active site 269799005899 catalytic residues [active] 269799005900 DNA binding site [nucleotide binding] 269799005901 Int/Topo IB signature motif; other site 269799005902 Helix-turn-helix domain; Region: HTH_17; pfam12728 269799005903 transposase/IS protein; Provisional; Region: PRK09183 269799005904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799005905 Walker A motif; other site 269799005906 ATP binding site [chemical binding]; other site 269799005907 Walker B motif; other site 269799005908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 269799005909 Integrase core domain; Region: rve; pfam00665 269799005910 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 269799005911 active site 269799005912 8-oxo-dGMP binding site [chemical binding]; other site 269799005913 nudix motif; other site 269799005914 metal binding site [ion binding]; metal-binding site 269799005915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269799005916 putative DNA binding site [nucleotide binding]; other site 269799005917 dimerization interface [polypeptide binding]; other site 269799005918 putative Zn2+ binding site [ion binding]; other site 269799005919 Arabidopsis thaliana cystatin-related protein; Region: Atha_cystat_rel; TIGR01638 269799005920 SEFIR domain; Region: SEFIR; pfam08357 269799005921 AAA domain; Region: AAA_22; pfam13401 269799005922 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269799005923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799005924 TPR motif; other site 269799005925 binding surface 269799005926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 269799005927 binding surface 269799005928 TPR motif; other site 269799005929 Restriction endonuclease; Region: Mrr_cat; pfam04471 269799005930 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]; Region: RPB9; COG1594 269799005931 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 269799005932 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 269799005933 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799005934 acyl-activating enzyme (AAE) consensus motif; other site 269799005935 active site 269799005936 AMP binding site [chemical binding]; other site 269799005937 acyl-activating enzyme (AAE) consensus motif; other site 269799005938 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799005939 active site 269799005940 AMP binding site [chemical binding]; other site 269799005941 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 269799005942 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 269799005943 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 269799005944 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 269799005945 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 269799005946 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 269799005947 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 269799005948 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 269799005949 dimer interface [polypeptide binding]; other site 269799005950 putative functional site; other site 269799005951 putative MPT binding site; other site 269799005952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799005953 S-adenosylmethionine binding site [chemical binding]; other site 269799005954 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 269799005955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799005956 FeS/SAM binding site; other site 269799005957 conserved nucleotide sequence; Gmet_R0103 269799005958 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799005959 heme-binding residues [chemical binding]; other site 269799005960 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 269799005961 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799005962 molybdopterin cofactor binding site; other site 269799005963 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 269799005964 molybdopterin cofactor binding site; other site 269799005965 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 269799005966 4Fe-4S binding domain; Region: Fer4; cl02805 269799005967 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 269799005968 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 269799005969 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 269799005970 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 269799005971 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 269799005972 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 269799005973 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 269799005974 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 269799005975 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799005976 acyl-activating enzyme (AAE) consensus motif; other site 269799005977 AMP binding site [chemical binding]; other site 269799005978 active site 269799005979 CoA binding site [chemical binding]; other site 269799005980 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 269799005981 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 269799005982 Walker A/P-loop; other site 269799005983 ATP binding site [chemical binding]; other site 269799005984 Q-loop/lid; other site 269799005985 ABC transporter signature motif; other site 269799005986 Walker B; other site 269799005987 D-loop; other site 269799005988 H-loop/switch region; other site 269799005989 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 269799005990 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 269799005991 Walker A/P-loop; other site 269799005992 ATP binding site [chemical binding]; other site 269799005993 Q-loop/lid; other site 269799005994 ABC transporter signature motif; other site 269799005995 Walker B; other site 269799005996 D-loop; other site 269799005997 H-loop/switch region; other site 269799005998 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 269799005999 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 269799006000 TM-ABC transporter signature motif; other site 269799006001 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 269799006002 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 269799006003 TM-ABC transporter signature motif; other site 269799006004 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 269799006005 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 269799006006 putative ligand binding site [chemical binding]; other site 269799006007 ACT domain-containing protein [General function prediction only]; Region: COG4747 269799006008 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 269799006009 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 269799006010 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799006011 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 269799006012 acyl-activating enzyme (AAE) consensus motif; other site 269799006013 AMP binding site [chemical binding]; other site 269799006014 active site 269799006015 CoA binding site [chemical binding]; other site 269799006016 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 269799006017 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 269799006018 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269799006019 dimer interface [polypeptide binding]; other site 269799006020 PYR/PP interface [polypeptide binding]; other site 269799006021 TPP binding site [chemical binding]; other site 269799006022 substrate binding site [chemical binding]; other site 269799006023 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 269799006024 TPP-binding site; other site 269799006025 conserved nucleotide sequence; Gmet_P1827 269799006026 exopolyphosphatase; Region: exo_poly_only; TIGR03706 269799006027 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 269799006028 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 269799006029 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 269799006030 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 269799006031 PhoU domain; Region: PhoU; pfam01895 269799006032 PhoU domain; Region: PhoU; pfam01895 269799006033 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269799006034 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799006035 ligand binding site [chemical binding]; other site 269799006036 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269799006037 IHF dimer interface [polypeptide binding]; other site 269799006038 IHF - DNA interface [nucleotide binding]; other site 269799006039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 269799006040 binding surface 269799006041 TPR motif; other site 269799006042 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 269799006043 TRAM domain; Region: TRAM; pfam01938 269799006044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269799006045 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 269799006046 rRNA binding site [nucleotide binding]; other site 269799006047 predicted 30S ribosome binding site; other site 269799006048 elongation factor P; Validated; Region: PRK00529 269799006049 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 269799006050 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 269799006051 RNA binding site [nucleotide binding]; other site 269799006052 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 269799006053 RNA binding site [nucleotide binding]; other site 269799006054 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 269799006055 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 269799006056 motif 1; other site 269799006057 dimer interface [polypeptide binding]; other site 269799006058 active site 269799006059 motif 2; other site 269799006060 motif 3; other site 269799006061 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 269799006062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799006063 FeS/SAM binding site; other site 269799006064 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 269799006065 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 269799006066 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 269799006067 heterodimer interface [polypeptide binding]; other site 269799006068 active site 269799006069 FMN binding site [chemical binding]; other site 269799006070 homodimer interface [polypeptide binding]; other site 269799006071 substrate binding site [chemical binding]; other site 269799006072 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 269799006073 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 269799006074 FAD binding pocket [chemical binding]; other site 269799006075 FAD binding motif [chemical binding]; other site 269799006076 phosphate binding motif [ion binding]; other site 269799006077 beta-alpha-beta structure motif; other site 269799006078 NAD binding pocket [chemical binding]; other site 269799006079 Iron coordination center [ion binding]; other site 269799006080 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 269799006081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269799006082 Coenzyme A binding pocket [chemical binding]; other site 269799006083 conserved nucleotide sequence; Gmet_P1844 269799006084 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 269799006085 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 269799006086 dimerization interface [polypeptide binding]; other site 269799006087 putative ATP binding site [chemical binding]; other site 269799006088 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 269799006089 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 269799006090 active site 269799006091 substrate binding site [chemical binding]; other site 269799006092 cosubstrate binding site; other site 269799006093 catalytic site [active] 269799006094 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799006095 heme-binding residues [chemical binding]; other site 269799006096 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 269799006097 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 269799006098 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 269799006099 generic binding surface II; other site 269799006100 generic binding surface I; other site 269799006101 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269799006102 AAA domain; Region: AAA_31; pfam13614 269799006103 P-loop; other site 269799006104 Magnesium ion binding site [ion binding]; other site 269799006105 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 269799006106 NodB motif; other site 269799006107 putative active site [active] 269799006108 putative catalytic site [active] 269799006109 Zn binding site [ion binding]; other site 269799006110 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 269799006111 dockerin binding interface; other site 269799006112 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 269799006113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 269799006114 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 269799006115 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 269799006116 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 269799006117 protein binding site [polypeptide binding]; other site 269799006118 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 269799006119 Catalytic dyad [active] 269799006120 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 269799006121 Peptidase family M23; Region: Peptidase_M23; pfam01551 269799006122 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 269799006123 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 269799006124 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 269799006125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799006126 Walker A/P-loop; other site 269799006127 ATP binding site [chemical binding]; other site 269799006128 Q-loop/lid; other site 269799006129 ABC transporter signature motif; other site 269799006130 Walker B; other site 269799006131 D-loop; other site 269799006132 H-loop/switch region; other site 269799006133 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 269799006134 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 269799006135 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 269799006136 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 269799006137 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 269799006138 TPR repeat; Region: TPR_11; pfam13414 269799006139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006140 binding surface 269799006141 TPR motif; other site 269799006142 TPR repeat; Region: TPR_11; pfam13414 269799006143 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 269799006144 Secretin and TonB N terminus short domain; Region: STN; smart00965 269799006145 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 269799006146 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 269799006147 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 269799006148 dockerin binding interface; other site 269799006149 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 269799006150 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 269799006151 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 269799006152 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269799006153 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 269799006154 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 269799006155 Walker A motif; other site 269799006156 ATP binding site [chemical binding]; other site 269799006157 Walker B motif; other site 269799006158 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 269799006159 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 269799006160 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 269799006161 NHL repeat; Region: NHL; pfam01436 269799006162 NHL repeat; Region: NHL; pfam01436 269799006163 NHL repeat; Region: NHL; pfam01436 269799006164 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 269799006165 Ligand binding site; other site 269799006166 Putative Catalytic site; other site 269799006167 DXD motif; other site 269799006168 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 269799006169 Found in ATP-dependent protease La (LON); Region: LON; smart00464 269799006170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799006171 Walker A motif; other site 269799006172 ATP binding site [chemical binding]; other site 269799006173 Walker B motif; other site 269799006174 arginine finger; other site 269799006175 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 269799006176 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 269799006177 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 269799006178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799006179 Walker A motif; other site 269799006180 ATP binding site [chemical binding]; other site 269799006181 Walker B motif; other site 269799006182 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 269799006183 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 269799006184 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 269799006185 oligomer interface [polypeptide binding]; other site 269799006186 active site residues [active] 269799006187 trigger factor; Region: tig; TIGR00115 269799006188 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269799006189 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 269799006190 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 269799006191 active site 269799006192 dimerization interface [polypeptide binding]; other site 269799006193 ribonuclease PH; Reviewed; Region: rph; PRK00173 269799006194 Ribonuclease PH; Region: RNase_PH_bact; cd11362 269799006195 hexamer interface [polypeptide binding]; other site 269799006196 active site 269799006197 DHH family; Region: DHH; pfam01368 269799006198 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 269799006199 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 269799006200 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 269799006201 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 269799006202 active site 269799006203 catalytic residues [active] 269799006204 metal binding site [ion binding]; metal-binding site 269799006205 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 269799006206 aspartate kinase; Reviewed; Region: PRK06635 269799006207 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 269799006208 putative nucleotide binding site [chemical binding]; other site 269799006209 putative catalytic residues [active] 269799006210 putative Mg ion binding site [ion binding]; other site 269799006211 putative aspartate binding site [chemical binding]; other site 269799006212 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 269799006213 putative allosteric regulatory site; other site 269799006214 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 269799006215 putative allosteric regulatory residue; other site 269799006216 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 269799006217 FOG: CBS domain [General function prediction only]; Region: COG0517 269799006218 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 269799006219 Uncharacterized conserved protein [Function unknown]; Region: COG0062 269799006220 putative carbohydrate kinase; Provisional; Region: PRK10565 269799006221 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 269799006222 putative substrate binding site [chemical binding]; other site 269799006223 putative ATP binding site [chemical binding]; other site 269799006224 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14656 269799006225 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 269799006226 active site 269799006227 hydrophilic channel; other site 269799006228 dimerization interface [polypeptide binding]; other site 269799006229 catalytic residues [active] 269799006230 active site lid [active] 269799006231 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 269799006232 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 269799006233 active site 269799006234 substrate binding site [chemical binding]; other site 269799006235 metal binding site [ion binding]; metal-binding site 269799006236 YbbR-like protein; Region: YbbR; pfam07949 269799006237 Uncharacterized conserved protein [Function unknown]; Region: COG1624 269799006238 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 269799006239 dihydropteroate synthase; Region: DHPS; TIGR01496 269799006240 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 269799006241 substrate binding pocket [chemical binding]; other site 269799006242 dimer interface [polypeptide binding]; other site 269799006243 inhibitor binding site; inhibition site 269799006244 FtsH Extracellular; Region: FtsH_ext; pfam06480 269799006245 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 269799006246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799006247 Walker A motif; other site 269799006248 ATP binding site [chemical binding]; other site 269799006249 Walker B motif; other site 269799006250 arginine finger; other site 269799006251 Peptidase family M41; Region: Peptidase_M41; pfam01434 269799006252 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 269799006253 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 269799006254 TilS substrate C-terminal domain; Region: TilS_C; smart00977 269799006255 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 269799006256 AAA domain; Region: AAA_30; pfam13604 269799006257 Family description; Region: UvrD_C_2; pfam13538 269799006258 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 269799006259 Family description; Region: UvrD_C_2; pfam13538 269799006260 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 269799006261 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 269799006262 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 269799006263 MarR family; Region: MarR_2; pfam12802 269799006264 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 269799006265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799006266 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 269799006267 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 269799006268 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 269799006269 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 269799006270 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 269799006271 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 269799006272 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 269799006273 Walker A/P-loop; other site 269799006274 ATP binding site [chemical binding]; other site 269799006275 Q-loop/lid; other site 269799006276 ABC transporter signature motif; other site 269799006277 Walker B; other site 269799006278 D-loop; other site 269799006279 H-loop/switch region; other site 269799006280 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 269799006281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799006282 dimer interface [polypeptide binding]; other site 269799006283 conserved gate region; other site 269799006284 putative PBP binding loops; other site 269799006285 ABC-ATPase subunit interface; other site 269799006286 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 269799006287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269799006288 substrate binding pocket [chemical binding]; other site 269799006289 membrane-bound complex binding site; other site 269799006290 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 269799006291 ACS interaction site; other site 269799006292 CODH interaction site; other site 269799006293 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 269799006294 cubane metal cluster (B-cluster) [ion binding]; other site 269799006295 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 269799006296 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 269799006297 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 269799006298 Walker A/P-loop; other site 269799006299 ATP binding site [chemical binding]; other site 269799006300 Q-loop/lid; other site 269799006301 ABC transporter signature motif; other site 269799006302 Walker B; other site 269799006303 D-loop; other site 269799006304 H-loop/switch region; other site 269799006305 TOBE-like domain; Region: TOBE_3; pfam12857 269799006306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799006307 dimer interface [polypeptide binding]; other site 269799006308 conserved gate region; other site 269799006309 putative PBP binding loops; other site 269799006310 ABC-ATPase subunit interface; other site 269799006311 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 269799006312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799006313 dimer interface [polypeptide binding]; other site 269799006314 conserved gate region; other site 269799006315 putative PBP binding loops; other site 269799006316 ABC-ATPase subunit interface; other site 269799006317 conserved nucleotide sequence; Gmet_R1019 269799006318 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 269799006319 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 269799006320 Predicted transcriptional regulator [Transcription]; Region: COG1959 269799006321 Transcriptional regulator; Region: Rrf2; pfam02082 269799006322 Transcriptional regulator; Region: Rrf2; cl17282 269799006323 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 269799006324 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 269799006325 heme binding site [chemical binding]; other site 269799006326 ferroxidase pore; other site 269799006327 ferroxidase diiron center [ion binding]; other site 269799006328 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 269799006329 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 269799006330 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 269799006331 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 269799006332 active site 269799006333 dimer interface [polypeptide binding]; other site 269799006334 effector binding site; other site 269799006335 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 269799006336 conserved nucleotide sequence; Gmet_R0104 269799006337 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 269799006338 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 269799006339 substrate binding site [chemical binding]; other site 269799006340 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 269799006341 substrate binding site [chemical binding]; other site 269799006342 ligand binding site [chemical binding]; other site 269799006343 conserved nucleotide sequence; Gmet_P1912 269799006344 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 269799006345 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 269799006346 dimer interface [polypeptide binding]; other site 269799006347 motif 1; other site 269799006348 active site 269799006349 motif 2; other site 269799006350 motif 3; other site 269799006351 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 269799006352 anticodon binding site; other site 269799006353 Response regulator receiver domain; Region: Response_reg; pfam00072 269799006354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799006355 active site 269799006356 phosphorylation site [posttranslational modification] 269799006357 intermolecular recognition site; other site 269799006358 dimerization interface [polypeptide binding]; other site 269799006359 GAF domain; Region: GAF_3; pfam13492 269799006360 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799006361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799006362 metal binding site [ion binding]; metal-binding site 269799006363 active site 269799006364 I-site; other site 269799006365 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 269799006366 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 269799006367 Competence protein; Region: Competence; pfam03772 269799006368 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 269799006369 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 269799006370 metal binding site [ion binding]; metal-binding site 269799006371 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799006372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799006373 active site 269799006374 phosphorylation site [posttranslational modification] 269799006375 intermolecular recognition site; other site 269799006376 PAS domain S-box; Region: sensory_box; TIGR00229 269799006377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799006378 putative active site [active] 269799006379 heme pocket [chemical binding]; other site 269799006380 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799006381 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799006382 metal binding site [ion binding]; metal-binding site 269799006383 active site 269799006384 I-site; other site 269799006385 Response regulator receiver domain; Region: Response_reg; pfam00072 269799006386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799006387 active site 269799006388 phosphorylation site [posttranslational modification] 269799006389 intermolecular recognition site; other site 269799006390 dimerization interface [polypeptide binding]; other site 269799006391 histidine kinase; Provisional; Region: PRK13557 269799006392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799006393 putative active site [active] 269799006394 heme pocket [chemical binding]; other site 269799006395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799006396 dimer interface [polypeptide binding]; other site 269799006397 phosphorylation site [posttranslational modification] 269799006398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799006399 ATP binding site [chemical binding]; other site 269799006400 Mg2+ binding site [ion binding]; other site 269799006401 G-X-G motif; other site 269799006402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799006403 active site 269799006404 phosphorylation site [posttranslational modification] 269799006405 intermolecular recognition site; other site 269799006406 dimerization interface [polypeptide binding]; other site 269799006407 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 269799006408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799006409 active site 269799006410 phosphorylation site [posttranslational modification] 269799006411 intermolecular recognition site; other site 269799006412 dimerization interface [polypeptide binding]; other site 269799006413 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799006414 Zn2+ binding site [ion binding]; other site 269799006415 Mg2+ binding site [ion binding]; other site 269799006416 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 269799006417 AMP binding site [chemical binding]; other site 269799006418 metal binding site [ion binding]; metal-binding site 269799006419 active site 269799006420 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 269799006421 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 269799006422 iron-sulfur cluster [ion binding]; other site 269799006423 [2Fe-2S] cluster binding site [ion binding]; other site 269799006424 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 269799006425 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 269799006426 intrachain domain interface; other site 269799006427 interchain domain interface [polypeptide binding]; other site 269799006428 heme bH binding site [chemical binding]; other site 269799006429 Qi binding site; other site 269799006430 heme bL binding site [chemical binding]; other site 269799006431 Qo binding site; other site 269799006432 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 269799006433 interchain domain interface [polypeptide binding]; other site 269799006434 intrachain domain interface; other site 269799006435 Qi binding site; other site 269799006436 Qo binding site; other site 269799006437 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 269799006438 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 269799006439 heme-binding residues [chemical binding]; other site 269799006440 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 269799006441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799006442 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799006443 ABC transporter; Region: ABC_tran_2; pfam12848 269799006444 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799006445 Tim44-like domain; Region: Tim44; pfam04280 269799006446 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269799006447 diiron binding motif [ion binding]; other site 269799006448 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 269799006449 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 269799006450 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 269799006451 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 269799006452 conserved palindrome; Gmet_P1930 269799006453 Rrf2 family protein; Region: rrf2_super; TIGR00738 269799006454 Transcriptional regulator; Region: Rrf2; pfam02082 269799006455 TPR repeat; Region: TPR_11; pfam13414 269799006456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006457 binding surface 269799006458 TPR motif; other site 269799006459 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799006460 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799006461 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 269799006462 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269799006463 HSP70 interaction site [polypeptide binding]; other site 269799006464 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 269799006465 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 269799006466 TPP-binding site; other site 269799006467 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269799006468 PYR/PP interface [polypeptide binding]; other site 269799006469 dimer interface [polypeptide binding]; other site 269799006470 TPP binding site [chemical binding]; other site 269799006471 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269799006472 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 269799006473 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 269799006474 substrate binding pocket [chemical binding]; other site 269799006475 chain length determination region; other site 269799006476 substrate-Mg2+ binding site; other site 269799006477 catalytic residues [active] 269799006478 aspartate-rich region 1; other site 269799006479 active site lid residues [active] 269799006480 aspartate-rich region 2; other site 269799006481 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14066 269799006482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269799006483 active site 269799006484 amidophosphoribosyltransferase; Provisional; Region: PRK09123 269799006485 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 269799006486 active site 269799006487 tetramer interface [polypeptide binding]; other site 269799006488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269799006489 active site 269799006490 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 269799006491 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 269799006492 conserved cys residue [active] 269799006493 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 269799006494 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 269799006495 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 269799006496 dimerization interface [polypeptide binding]; other site 269799006497 ATP binding site [chemical binding]; other site 269799006498 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 269799006499 dimerization interface [polypeptide binding]; other site 269799006500 ATP binding site [chemical binding]; other site 269799006501 Mechanosensitive ion channel; Region: MS_channel; pfam00924 269799006502 adenylosuccinate lyase; Provisional; Region: PRK07492 269799006503 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 269799006504 tetramer interface [polypeptide binding]; other site 269799006505 active site 269799006506 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 269799006507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799006508 dimerization interface [polypeptide binding]; other site 269799006509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799006510 putative active site [active] 269799006511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799006512 heme pocket [chemical binding]; other site 269799006513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799006514 dimer interface [polypeptide binding]; other site 269799006515 phosphorylation site [posttranslational modification] 269799006516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799006517 ATP binding site [chemical binding]; other site 269799006518 Mg2+ binding site [ion binding]; other site 269799006519 G-X-G motif; other site 269799006520 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 269799006521 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 269799006522 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 269799006523 Phosphoglycerate kinase; Region: PGK; pfam00162 269799006524 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 269799006525 substrate binding site [chemical binding]; other site 269799006526 hinge regions; other site 269799006527 ADP binding site [chemical binding]; other site 269799006528 catalytic site [active] 269799006529 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 269799006530 triosephosphate isomerase; Provisional; Region: PRK14565 269799006531 substrate binding site [chemical binding]; other site 269799006532 dimer interface [polypeptide binding]; other site 269799006533 catalytic triad [active] 269799006534 Preprotein translocase SecG subunit; Region: SecG; pfam03840 269799006535 palindrome; Gmet_P3607 269799006536 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 269799006537 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 269799006538 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 269799006539 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269799006540 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269799006541 catalytic residue [active] 269799006542 conserved nucleotide sequence; Gmet_P1953 269799006543 L-aspartate oxidase; Provisional; Region: PRK09077 269799006544 L-aspartate oxidase; Provisional; Region: PRK06175 269799006545 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 269799006546 Chorismate mutase type II; Region: CM_2; smart00830 269799006547 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 269799006548 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 269799006549 putative ligand binding pocket/active site [active] 269799006550 putative metal binding site [ion binding]; other site 269799006551 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 269799006552 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 269799006553 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 269799006554 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 269799006555 active site 269799006556 HIGH motif; other site 269799006557 dimer interface [polypeptide binding]; other site 269799006558 KMSKS motif; other site 269799006559 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 269799006560 Peptidase family M50; Region: Peptidase_M50; pfam02163 269799006561 active site 269799006562 putative substrate binding region [chemical binding]; other site 269799006563 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 269799006564 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 269799006565 putative active site [active] 269799006566 Tetratricopeptide repeat; Region: TPR_15; pfam13429 269799006567 TM1410 hypothetical-related protein; Region: DUF297; cl00997 269799006568 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 269799006569 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 269799006570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799006571 Predicted membrane protein [Function unknown]; Region: COG4267 269799006572 TRAM domain; Region: TRAM; pfam01938 269799006573 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 269799006574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799006575 S-adenosylmethionine binding site [chemical binding]; other site 269799006576 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 269799006577 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 269799006578 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 269799006579 endonuclease III; Region: ENDO3c; smart00478 269799006580 minor groove reading motif; other site 269799006581 helix-hairpin-helix signature motif; other site 269799006582 substrate binding pocket [chemical binding]; other site 269799006583 active site 269799006584 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 269799006585 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 269799006586 active site 269799006587 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 269799006588 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799006589 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799006590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799006591 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799006592 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 269799006593 BON domain; Region: BON; pfam04972 269799006594 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 269799006595 MgtC family; Region: MgtC; pfam02308 269799006596 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 269799006597 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 269799006598 G3 box; other site 269799006599 Switch II region; other site 269799006600 GTP/Mg2+ binding site [chemical binding]; other site 269799006601 G4 box; other site 269799006602 G5 box; other site 269799006603 Sporulation related domain; Region: SPOR; pfam05036 269799006604 Sporulation related domain; Region: SPOR; pfam05036 269799006605 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 269799006606 elongation factor G; Reviewed; Region: PRK12740 269799006607 G1 box; other site 269799006608 putative GEF interaction site [polypeptide binding]; other site 269799006609 GTP/Mg2+ binding site [chemical binding]; other site 269799006610 Switch I region; other site 269799006611 G2 box; other site 269799006612 G3 box; other site 269799006613 Switch II region; other site 269799006614 G4 box; other site 269799006615 G5 box; other site 269799006616 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 269799006617 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 269799006618 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 269799006619 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 269799006620 nucleotide binding site [chemical binding]; other site 269799006621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269799006622 dimerization interface [polypeptide binding]; other site 269799006623 putative DNA binding site [nucleotide binding]; other site 269799006624 putative Zn2+ binding site [ion binding]; other site 269799006625 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 269799006626 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 269799006627 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 269799006628 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 269799006629 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 269799006630 dimerization interface [polypeptide binding]; other site 269799006631 active site 269799006632 conserved nucleotide sequence; Gmet_P1988 269799006633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799006634 dimerization interface [polypeptide binding]; other site 269799006635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799006636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799006637 metal binding site [ion binding]; metal-binding site 269799006638 active site 269799006639 I-site; other site 269799006640 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799006641 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799006642 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799006643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799006644 dimer interface [polypeptide binding]; other site 269799006645 phosphorylation site [posttranslational modification] 269799006646 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799006647 GAF domain; Region: GAF; pfam01590 269799006648 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799006649 Zn2+ binding site [ion binding]; other site 269799006650 Mg2+ binding site [ion binding]; other site 269799006651 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 269799006652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799006653 active site 269799006654 phosphorylation site [posttranslational modification] 269799006655 intermolecular recognition site; other site 269799006656 dimerization interface [polypeptide binding]; other site 269799006657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799006658 Walker A motif; other site 269799006659 ATP binding site [chemical binding]; other site 269799006660 Walker B motif; other site 269799006661 arginine finger; other site 269799006662 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799006663 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 269799006664 GAF domain; Region: GAF_3; pfam13492 269799006665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799006666 dimer interface [polypeptide binding]; other site 269799006667 phosphorylation site [posttranslational modification] 269799006668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799006669 ATP binding site [chemical binding]; other site 269799006670 Mg2+ binding site [ion binding]; other site 269799006671 G-X-G motif; other site 269799006672 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 269799006673 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 269799006674 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 269799006675 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 269799006676 CARDB; Region: CARDB; pfam07705 269799006677 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 269799006678 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799006679 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 269799006680 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799006681 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799006682 EpsI family protein; Region: EpsI_fam; TIGR02914 269799006683 exosortase A; Region: exosortase_1; TIGR03109 269799006684 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 269799006685 conserved nucleotide sequence; Gmet_R0105 269799006686 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 269799006687 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 269799006688 putative ADP-binding pocket [chemical binding]; other site 269799006689 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 269799006690 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 269799006691 putative active site [active] 269799006692 putative catalytic site [active] 269799006693 conserved nucleotide sequence; Gmet_R0106 269799006694 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 269799006695 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 269799006696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799006697 catalytic residue [active] 269799006698 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799006699 acyl-activating enzyme (AAE) consensus motif; other site 269799006700 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 269799006701 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799006702 active site 269799006703 CoA binding site [chemical binding]; other site 269799006704 AMP binding site [chemical binding]; other site 269799006705 conserved nucleotide sequence; Gmet_R0107 269799006706 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 269799006707 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269799006708 DXD motif; other site 269799006709 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 269799006710 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 269799006711 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269799006712 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269799006713 active site 269799006714 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799006715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799006716 S-adenosylmethionine binding site [chemical binding]; other site 269799006717 colanic acid exporter; Provisional; Region: PRK10459 269799006718 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 269799006719 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 269799006720 putative active site [active] 269799006721 putative metal binding site [ion binding]; other site 269799006722 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269799006723 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 269799006724 active site 269799006725 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 269799006726 active site residue [active] 269799006727 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 269799006728 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 269799006729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799006730 catalytic residue [active] 269799006731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 269799006732 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 269799006733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 269799006734 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 269799006735 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 269799006736 dimer interface [polypeptide binding]; other site 269799006737 active site 269799006738 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269799006739 catalytic residues [active] 269799006740 substrate binding site [chemical binding]; other site 269799006741 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 269799006742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799006743 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 269799006744 acyl-activating enzyme (AAE) consensus motif; other site 269799006745 acyl-activating enzyme (AAE) consensus motif; other site 269799006746 putative AMP binding site [chemical binding]; other site 269799006747 putative active site [active] 269799006748 putative CoA binding site [chemical binding]; other site 269799006749 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 269799006750 conserved nucleotide sequence; Gmet_I404 269799006751 conserved nucleotide sequence; Gmet_I405 269799006752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 269799006753 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 269799006754 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 269799006755 putative active site [active] 269799006756 putative metal binding site [ion binding]; other site 269799006757 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 269799006758 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269799006759 dimer interface [polypeptide binding]; other site 269799006760 active site 269799006761 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269799006762 Ligand Binding Site [chemical binding]; other site 269799006763 Molecular Tunnel; other site 269799006764 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 269799006765 active site 269799006766 cosubstrate binding site; other site 269799006767 substrate binding site [chemical binding]; other site 269799006768 catalytic site [active] 269799006769 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 269799006770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799006771 Walker A motif; other site 269799006772 ATP binding site [chemical binding]; other site 269799006773 Walker B motif; other site 269799006774 arginine finger; other site 269799006775 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 269799006776 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 269799006777 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799006778 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 269799006779 Chain length determinant protein; Region: Wzz; cl15801 269799006780 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 269799006781 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 269799006782 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 269799006783 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 269799006784 SLBB domain; Region: SLBB; pfam10531 269799006785 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 269799006786 Bacterial sugar transferase; Region: Bac_transf; pfam02397 269799006787 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 269799006788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006789 binding surface 269799006790 TPR motif; other site 269799006791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006792 TPR motif; other site 269799006793 binding surface 269799006794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006795 binding surface 269799006796 TPR motif; other site 269799006797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006798 binding surface 269799006799 TPR motif; other site 269799006800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006801 TPR motif; other site 269799006802 binding surface 269799006803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006804 binding surface 269799006805 TPR motif; other site 269799006806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006807 TPR motif; other site 269799006808 binding surface 269799006809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799006810 binding surface 269799006811 TPR motif; other site 269799006812 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269799006813 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799006814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799006815 active site 269799006816 phosphorylation site [posttranslational modification] 269799006817 intermolecular recognition site; other site 269799006818 dimerization interface [polypeptide binding]; other site 269799006819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799006820 Walker A motif; other site 269799006821 ATP binding site [chemical binding]; other site 269799006822 Walker B motif; other site 269799006823 arginine finger; other site 269799006824 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799006825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799006826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799006827 dimer interface [polypeptide binding]; other site 269799006828 phosphorylation site [posttranslational modification] 269799006829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799006830 ATP binding site [chemical binding]; other site 269799006831 Mg2+ binding site [ion binding]; other site 269799006832 G-X-G motif; other site 269799006833 CAAX prenyl protease-related protein; Region: pepcterm_CAAX; TIGR03008 269799006834 N-acyl amino acid synthase, PEP-CTERM/exosortase system-associated; Region: exosort_acyl; TIGR03694 269799006835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 269799006836 Winged helix-turn helix; Region: HTH_29; pfam13551 269799006837 Homeodomain-like domain; Region: HTH_23; pfam13384 269799006838 Homeodomain-like domain; Region: HTH_32; pfam13565 269799006839 DDE superfamily endonuclease; Region: DDE_3; pfam13358 269799006840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 269799006841 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 269799006842 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 269799006843 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 269799006844 homodimer interface [polypeptide binding]; other site 269799006845 active site 269799006846 TDP-binding site; other site 269799006847 acceptor substrate-binding pocket; other site 269799006848 Cna protein B-type domain; Region: Cna_B; pfam05738 269799006849 Cna protein B-type domain; Region: Cna_B; pfam05738 269799006850 Cna protein B-type domain; Region: Cna_B; pfam05738 269799006851 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 269799006852 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 269799006853 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 269799006854 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 269799006855 dimer interface [polypeptide binding]; other site 269799006856 hypothetical protein; Validated; Region: PRK08223 269799006857 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 269799006858 ATP binding site [chemical binding]; other site 269799006859 substrate interface [chemical binding]; other site 269799006860 MoeZ/MoeB domain; Region: MoeZ_MoeB; pfam05237 269799006861 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 269799006862 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799006863 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799006864 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799006865 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799006866 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 269799006867 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 269799006868 Protein of unknown function (DUF512); Region: DUF512; pfam04459 269799006869 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 269799006870 Domain of unknown function DUF20; Region: UPF0118; pfam01594 269799006871 bacterial Hfq-like; Region: Hfq; cd01716 269799006872 hexamer interface [polypeptide binding]; other site 269799006873 Sm1 motif; other site 269799006874 RNA binding site [nucleotide binding]; other site 269799006875 Sm2 motif; other site 269799006876 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 269799006877 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 269799006878 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 269799006879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799006880 ATP binding site [chemical binding]; other site 269799006881 Mg2+ binding site [ion binding]; other site 269799006882 G-X-G motif; other site 269799006883 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 269799006884 ATP binding site [chemical binding]; other site 269799006885 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 269799006886 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 269799006887 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269799006888 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269799006889 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 269799006890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799006891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799006892 Walker A motif; other site 269799006893 ATP binding site [chemical binding]; other site 269799006894 Walker B motif; other site 269799006895 arginine finger; other site 269799006896 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799006897 Amidohydrolase; Region: Amidohydro_2; pfam04909 269799006898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799006899 enoyl-CoA hydratase; Provisional; Region: PRK09245 269799006900 substrate binding site [chemical binding]; other site 269799006901 oxyanion hole (OAH) forming residues; other site 269799006902 trimer interface [polypeptide binding]; other site 269799006903 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 269799006904 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269799006905 dimer interface [polypeptide binding]; other site 269799006906 active site 269799006907 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 269799006908 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 269799006909 NAD(P) binding site [chemical binding]; other site 269799006910 homotetramer interface [polypeptide binding]; other site 269799006911 homodimer interface [polypeptide binding]; other site 269799006912 active site 269799006913 conserved nucleotide sequence; Gmet_R0158 269799006914 Fusaric acid resistance protein family; Region: FUSC; pfam04632 269799006915 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 269799006916 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 269799006917 Na binding site [ion binding]; other site 269799006918 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799006919 GAF domain; Region: GAF_2; pfam13185 269799006920 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 269799006921 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 269799006922 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269799006923 active site 269799006924 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269799006925 active site 269799006926 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 269799006927 Transcriptional regulator [Transcription]; Region: IclR; COG1414 269799006928 Bacterial transcriptional regulator; Region: IclR; pfam01614 269799006929 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799006930 Cysteine-rich domain; Region: CCG; pfam02754 269799006931 Cysteine-rich domain; Region: CCG; pfam02754 269799006932 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799006933 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269799006934 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799006935 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799006936 Ligand binding site [chemical binding]; other site 269799006937 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799006938 'integration host factor binding site, putative; Gmet_I115A' 269799006939 'integration host factor binding site, putative; Gmet_I115B' 269799006940 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 269799006941 CoA binding domain; Region: CoA_binding; smart00881 269799006942 CoA-ligase; Region: Ligase_CoA; pfam00549 269799006943 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 269799006944 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 269799006945 CoA-ligase; Region: Ligase_CoA; pfam00549 269799006946 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 269799006947 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799006948 4Fe-4S binding domain; Region: Fer4; cl02805 269799006949 Cysteine-rich domain; Region: CCG; pfam02754 269799006950 Cysteine-rich domain; Region: CCG; pfam02754 269799006951 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 269799006952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799006953 substrate binding site [chemical binding]; other site 269799006954 oxyanion hole (OAH) forming residues; other site 269799006955 trimer interface [polypeptide binding]; other site 269799006956 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 269799006957 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 269799006958 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 269799006959 'integration host factor binding site, putative; Gmet_I116A' 269799006960 'integration host factor binding site, putative; Gmet_I116B' 269799006961 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799006962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799006963 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799006964 putative acyltransferase; Provisional; Region: PRK05790 269799006965 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269799006966 dimer interface [polypeptide binding]; other site 269799006967 active site 269799006968 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269799006969 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799006970 active site 269799006971 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 269799006972 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 269799006973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269799006974 Coenzyme A binding pocket [chemical binding]; other site 269799006975 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 269799006976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269799006977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799006978 homodimer interface [polypeptide binding]; other site 269799006979 catalytic residue [active] 269799006980 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799006981 catalytic loop [active] 269799006982 iron binding site [ion binding]; other site 269799006983 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799006984 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 269799006985 dimer interface [polypeptide binding]; other site 269799006986 [2Fe-2S] cluster binding site [ion binding]; other site 269799006987 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 269799006988 SLBB domain; Region: SLBB; pfam10531 269799006989 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 269799006990 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 269799006991 4Fe-4S binding domain; Region: Fer4; pfam00037 269799006992 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 269799006993 4Fe-4S binding domain; Region: Fer4; pfam00037 269799006994 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 269799006995 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 269799006996 putative dimer interface [polypeptide binding]; other site 269799006997 [2Fe-2S] cluster binding site [ion binding]; other site 269799006998 conserved nucleotide sequence; Gmet_R4003 269799006999 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 269799007000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269799007001 putative DNA binding site [nucleotide binding]; other site 269799007002 putative Zn2+ binding site [ion binding]; other site 269799007003 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 269799007004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799007005 4Fe-4S binding domain; Region: Fer4; pfam00037 269799007006 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 269799007007 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 269799007008 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799007009 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799007010 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799007011 Cysteine-rich domain; Region: CCG; pfam02754 269799007012 Cysteine-rich domain; Region: CCG; pfam02754 269799007013 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 269799007014 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 269799007015 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 269799007016 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 269799007017 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200 269799007018 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799007019 substrate binding site [chemical binding]; other site 269799007020 oxyanion hole (OAH) forming residues; other site 269799007021 trimer interface [polypeptide binding]; other site 269799007022 Transposase domain (DUF772); Region: DUF772; pfam05598 269799007023 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799007024 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 269799007025 integrase Gmet_2271 5' region; Gmet_R0108 269799007026 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799007027 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799007028 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799007029 MOSC domain; Region: MOSC; pfam03473 269799007030 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 269799007031 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799007032 FeS/SAM binding site; other site 269799007033 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 269799007034 putative acetyltransferase; Provisional; Region: PRK03624 269799007035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269799007036 Coenzyme A binding pocket [chemical binding]; other site 269799007037 Rrf2 family protein; Region: rrf2_super; TIGR00738 269799007038 Transcriptional regulator; Region: Rrf2; pfam02082 269799007039 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 269799007040 Activator of aromatic catabolism; Region: XylR_N; pfam06505 269799007041 V4R domain; Region: V4R; pfam02830 269799007042 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 269799007043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799007044 Walker A motif; other site 269799007045 ATP binding site [chemical binding]; other site 269799007046 Walker B motif; other site 269799007047 arginine finger; other site 269799007048 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799007049 hypothetical protein; Provisional; Region: PRK08296 269799007050 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269799007051 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 269799007052 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 269799007053 hypothetical protein; Provisional; Region: PRK02399 269799007054 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 269799007055 FOG: CBS domain [General function prediction only]; Region: COG0517 269799007056 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 269799007057 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 269799007058 Flavoprotein; Region: Flavoprotein; pfam02441 269799007059 butyrate kinase; Provisional; Region: PRK03011 269799007060 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 269799007061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799007062 Zn2+ binding site [ion binding]; other site 269799007063 Mg2+ binding site [ion binding]; other site 269799007064 PAS domain S-box; Region: sensory_box; TIGR00229 269799007065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799007066 putative active site [active] 269799007067 heme pocket [chemical binding]; other site 269799007068 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 269799007069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799007070 Walker A motif; other site 269799007071 ATP binding site [chemical binding]; other site 269799007072 Walker B motif; other site 269799007073 arginine finger; other site 269799007074 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799007075 hypothetical protein; Provisional; Region: PRK02399 269799007076 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 269799007077 conserved nucleotide sequence; Gmet_R7003 269799007078 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 269799007079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799007080 motif II; other site 269799007081 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 269799007082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 269799007083 Activator of aromatic catabolism; Region: XylR_N; pfam06505 269799007084 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 269799007085 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 269799007086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799007087 Walker A motif; other site 269799007088 ATP binding site [chemical binding]; other site 269799007089 Walker B motif; other site 269799007090 arginine finger; other site 269799007091 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799007092 PAS domain; Region: PAS_9; pfam13426 269799007093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799007094 putative active site [active] 269799007095 heme pocket [chemical binding]; other site 269799007096 PAS domain; Region: PAS_9; pfam13426 269799007097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799007098 putative active site [active] 269799007099 heme pocket [chemical binding]; other site 269799007100 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 269799007101 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 269799007102 Activator of aromatic catabolism; Region: XylR_N; pfam06505 269799007103 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 269799007104 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 269799007105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799007106 Walker A motif; other site 269799007107 ATP binding site [chemical binding]; other site 269799007108 Walker B motif; other site 269799007109 arginine finger; other site 269799007110 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799007111 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 269799007112 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269799007113 4Fe-4S binding domain; Region: Fer4; pfam00037 269799007114 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 269799007115 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 269799007116 intrachain domain interface; other site 269799007117 heme bH binding site [chemical binding]; other site 269799007118 heme bL binding site [chemical binding]; other site 269799007119 interchain domain interface [polypeptide binding]; other site 269799007120 Qo binding site; other site 269799007121 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 269799007122 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 269799007123 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 269799007124 iron-sulfur cluster [ion binding]; other site 269799007125 [2Fe-2S] cluster binding site [ion binding]; other site 269799007126 Cytochrome c; Region: Cytochrom_C; pfam00034 269799007127 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 269799007128 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269799007129 FAD binding domain; Region: FAD_binding_4; pfam01565 269799007130 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 269799007131 FAD binding domain; Region: FAD_binding_4; pfam01565 269799007132 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 269799007133 butyrate kinase; Provisional; Region: PRK03011 269799007134 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 269799007135 classical (c) SDRs; Region: SDR_c; cd05233 269799007136 NAD(P) binding site [chemical binding]; other site 269799007137 active site 269799007138 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 269799007139 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 269799007140 Pseudomonas putida vanillin dehydrogenase-like; Region: ALDH_VaniDH_like; cd07150 269799007141 NAD(P) binding site [chemical binding]; other site 269799007142 catalytic residues [active] 269799007143 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 269799007144 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 269799007145 MarR family; Region: MarR_2; pfam12802 269799007146 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 269799007147 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 269799007148 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 269799007149 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799007150 catalytic loop [active] 269799007151 iron binding site [ion binding]; other site 269799007152 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 269799007153 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 269799007154 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 269799007155 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 269799007156 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 269799007157 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 269799007158 XdhC Rossmann domain; Region: XdhC_C; pfam13478 269799007159 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 269799007160 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 269799007161 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 269799007162 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 269799007163 Ligand binding site; other site 269799007164 metal-binding site 269799007165 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 269799007166 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 269799007167 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269799007168 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269799007169 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 269799007170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269799007171 Coenzyme A binding pocket [chemical binding]; other site 269799007172 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 269799007173 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 269799007174 dimer interface [polypeptide binding]; other site 269799007175 acyl-activating enzyme (AAE) consensus motif; other site 269799007176 putative active site [active] 269799007177 putative AMP binding site [chemical binding]; other site 269799007178 putative CoA binding site [chemical binding]; other site 269799007179 chemical substrate binding site [chemical binding]; other site 269799007180 PBP superfamily domain; Region: PBP_like_2; cl17296 269799007181 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799007182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799007183 active site 269799007184 phosphorylation site [posttranslational modification] 269799007185 intermolecular recognition site; other site 269799007186 dimerization interface [polypeptide binding]; other site 269799007187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799007188 Walker A motif; other site 269799007189 ATP binding site [chemical binding]; other site 269799007190 Walker B motif; other site 269799007191 arginine finger; other site 269799007192 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799007193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799007194 dimer interface [polypeptide binding]; other site 269799007195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799007196 ATP binding site [chemical binding]; other site 269799007197 G-X-G motif; other site 269799007198 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 269799007199 active site 269799007200 conserved nucleotide sequence; Gmet_R0109 269799007201 cyclohexa-1,5-dienecarbonyl-CoA hydratase; Region: dienoyl_CoA_hyt; TIGR03189 269799007202 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799007203 substrate binding site [chemical binding]; other site 269799007204 oxyanion hole (OAH) forming residues; other site 269799007205 trimer interface [polypeptide binding]; other site 269799007206 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase; Region: dearomat_had; TIGR03201 269799007207 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 269799007208 putative NAD(P) binding site [chemical binding]; other site 269799007209 catalytic Zn binding site [ion binding]; other site 269799007210 structural Zn binding site [ion binding]; other site 269799007211 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799007212 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269799007213 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799007214 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799007215 Ligand binding site [chemical binding]; other site 269799007216 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799007217 conserved nucleotide sequence; Gmet_R7004 269799007218 multicopper oxidase; Provisional; Region: PRK10965 269799007219 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 269799007220 Multicopper oxidase; Region: Cu-oxidase; pfam00394 269799007221 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 269799007222 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 269799007223 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 269799007224 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 269799007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799007226 active site 269799007227 phosphorylation site [posttranslational modification] 269799007228 intermolecular recognition site; other site 269799007229 dimerization interface [polypeptide binding]; other site 269799007230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269799007231 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 269799007232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 269799007233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 269799007234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799007235 active site 269799007236 phosphorylation site [posttranslational modification] 269799007237 intermolecular recognition site; other site 269799007238 dimerization interface [polypeptide binding]; other site 269799007239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 269799007240 DNA binding residues [nucleotide binding] 269799007241 dimerization interface [polypeptide binding]; other site 269799007242 PAS fold; Region: PAS_4; pfam08448 269799007243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799007244 putative active site [active] 269799007245 heme pocket [chemical binding]; other site 269799007246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 269799007247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799007248 ATP binding site [chemical binding]; other site 269799007249 Mg2+ binding site [ion binding]; other site 269799007250 G-X-G motif; other site 269799007251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799007252 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799007253 conserved nucleotide sequence; Gmet_I406 269799007254 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 269799007255 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 269799007256 Mg++ binding site [ion binding]; other site 269799007257 putative catalytic motif [active] 269799007258 substrate binding site [chemical binding]; other site 269799007259 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 269799007260 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 269799007261 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269799007262 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 269799007263 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 269799007264 Family description; Region: VCBS; pfam13517 269799007265 Family description; Region: VCBS; pfam13517 269799007266 conserved nucleotide sequence; Gmet_R0110 269799007267 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 269799007268 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 269799007269 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269799007270 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 269799007271 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 269799007272 Family description; Region: VCBS; pfam13517 269799007273 Family description; Region: VCBS; pfam13517 269799007274 Family description; Region: VCBS; pfam13517 269799007275 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799007276 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799007277 conserved nucleotide sequence; Gmet_R7005 269799007278 Family description; Region: VCBS; pfam13517 269799007279 Family description; Region: VCBS; pfam13517 269799007280 Family description; Region: VCBS; pfam13517 269799007281 Family description; Region: VCBS; pfam13517 269799007282 Family description; Region: VCBS; pfam13517 269799007283 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799007284 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 269799007285 conserved nucleotide sequence; Gmet_R0111 269799007286 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799007287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799007288 S-adenosylmethionine binding site [chemical binding]; other site 269799007289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799007290 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 269799007291 putative ADP-binding pocket [chemical binding]; other site 269799007292 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 269799007293 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 269799007294 active site 269799007295 dimer interface [polypeptide binding]; other site 269799007296 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 269799007297 Ligand Binding Site [chemical binding]; other site 269799007298 Molecular Tunnel; other site 269799007299 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 269799007300 Right handed beta helix region; Region: Beta_helix; pfam13229 269799007301 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269799007302 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 269799007303 Probable Catalytic site; other site 269799007304 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269799007305 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 269799007306 Probable Catalytic site; other site 269799007307 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799007308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799007309 S-adenosylmethionine binding site [chemical binding]; other site 269799007310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 269799007311 Family description; Region: VCBS; pfam13517 269799007312 Family description; Region: VCBS; pfam13517 269799007313 Family description; Region: VCBS; pfam13517 269799007314 Family description; Region: VCBS; pfam13517 269799007315 Family description; Region: VCBS; pfam13517 269799007316 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 269799007317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269799007318 active site 269799007319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799007320 S-adenosylmethionine binding site [chemical binding]; other site 269799007321 colanic acid exporter; Provisional; Region: PRK10459 269799007322 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 269799007323 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 269799007324 Chain length determinant protein; Region: Wzz; pfam02706 269799007325 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 269799007326 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 269799007327 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 269799007328 SLBB domain; Region: SLBB; pfam10531 269799007329 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 269799007330 SLBB domain; Region: SLBB; pfam10531 269799007331 SLBB domain; Region: SLBB; pfam10531 269799007332 SLBB domain; Region: SLBB; pfam10531 269799007333 comEA protein; Region: comE; TIGR01259 269799007334 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 269799007335 Interdomain contacts; other site 269799007336 Cytokine receptor motif; other site 269799007337 Fibronectin type III domain; Region: fn3; pfam00041 269799007338 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 269799007339 Interdomain contacts; other site 269799007340 Cytokine receptor motif; other site 269799007341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799007342 active site 269799007343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799007344 phosphorylation site [posttranslational modification] 269799007345 intermolecular recognition site; other site 269799007346 dimerization interface [polypeptide binding]; other site 269799007347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799007348 dimer interface [polypeptide binding]; other site 269799007349 phosphorylation site [posttranslational modification] 269799007350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799007351 ATP binding site [chemical binding]; other site 269799007352 Mg2+ binding site [ion binding]; other site 269799007353 G-X-G motif; other site 269799007354 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 269799007355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799007356 S-adenosylmethionine binding site [chemical binding]; other site 269799007357 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 269799007358 Uncharacterized conserved protein [Function unknown]; Region: COG3339 269799007359 Hemin uptake protein hemP; Region: hemP; pfam10636 269799007360 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 269799007361 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 269799007362 active site 269799007363 FMN binding site [chemical binding]; other site 269799007364 substrate binding site [chemical binding]; other site 269799007365 putative catalytic residue [active] 269799007366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269799007367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799007368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799007369 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 269799007370 NAD(P) binding site [chemical binding]; other site 269799007371 active site 269799007372 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 269799007373 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799007374 substrate binding site [chemical binding]; other site 269799007375 oxyanion hole (OAH) forming residues; other site 269799007376 trimer interface [polypeptide binding]; other site 269799007377 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799007378 substrate binding site [chemical binding]; other site 269799007379 trimer interface [polypeptide binding]; other site 269799007380 oxyanion hole (OAH) forming residues; other site 269799007381 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 269799007382 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269799007383 dimer interface [polypeptide binding]; other site 269799007384 active site 269799007385 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799007386 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 269799007387 active site 269799007388 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799007389 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 269799007390 FAD binding site [chemical binding]; other site 269799007391 substrate binding site [chemical binding]; other site 269799007392 catalytic base [active] 269799007393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269799007394 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 269799007395 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269799007396 active site 269799007397 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 269799007398 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 269799007399 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 269799007400 active site 269799007401 FMN binding site [chemical binding]; other site 269799007402 substrate binding site [chemical binding]; other site 269799007403 putative catalytic residue [active] 269799007404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269799007405 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 269799007406 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 269799007407 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 269799007408 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 269799007409 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799007410 substrate binding site [chemical binding]; other site 269799007411 oxyanion hole (OAH) forming residues; other site 269799007412 trimer interface [polypeptide binding]; other site 269799007413 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 269799007414 Coenzyme A transferase; Region: CoA_trans; cl17247 269799007415 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 269799007416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799007417 NAD(P) binding site [chemical binding]; other site 269799007418 active site 269799007419 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 269799007420 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799007421 substrate binding site [chemical binding]; other site 269799007422 oxyanion hole (OAH) forming residues; other site 269799007423 trimer interface [polypeptide binding]; other site 269799007424 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 269799007425 B12 binding site [chemical binding]; other site 269799007426 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cd00512 269799007427 ArgK protein; Region: ArgK; pfam03308 269799007428 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 269799007429 Walker A; other site 269799007430 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 269799007431 G4 box; other site 269799007432 G5 box; other site 269799007433 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799007434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269799007435 active site 269799007436 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 269799007437 enoyl-CoA hydratase; Provisional; Region: PRK06688 269799007438 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799007439 substrate binding site [chemical binding]; other site 269799007440 oxyanion hole (OAH) forming residues; other site 269799007441 trimer interface [polypeptide binding]; other site 269799007442 putative acyltransferase; Provisional; Region: PRK05790 269799007443 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269799007444 dimer interface [polypeptide binding]; other site 269799007445 active site 269799007446 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 269799007447 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 269799007448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799007449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799007450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799007451 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269799007452 NAD(P) binding site [chemical binding]; other site 269799007453 active site 269799007454 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 269799007455 active site 269799007456 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 269799007457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269799007458 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269799007459 active site 269799007460 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 269799007461 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 269799007462 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 269799007463 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 269799007464 GAF domain; Region: GAF; pfam01590 269799007465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799007466 Walker A motif; other site 269799007467 ATP binding site [chemical binding]; other site 269799007468 Walker B motif; other site 269799007469 arginine finger; other site 269799007470 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799007471 enoyl-CoA hydratase; Provisional; Region: PRK06688 269799007472 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799007473 substrate binding site [chemical binding]; other site 269799007474 oxyanion hole (OAH) forming residues; other site 269799007475 trimer interface [polypeptide binding]; other site 269799007476 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 269799007477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 269799007478 Predicted oxidoreductase [General function prediction only]; Region: COG3573 269799007479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799007480 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 269799007481 NAD(P) binding site [chemical binding]; other site 269799007482 active site 269799007483 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 269799007484 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 269799007485 putative [Fe4-S4] binding site [ion binding]; other site 269799007486 putative molybdopterin cofactor binding site [chemical binding]; other site 269799007487 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799007488 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 269799007489 putative molybdopterin cofactor binding site; other site 269799007490 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269799007491 active site 269799007492 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 269799007493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799007494 acyl-activating enzyme (AAE) consensus motif; other site 269799007495 AMP binding site [chemical binding]; other site 269799007496 active site 269799007497 CoA binding site [chemical binding]; other site 269799007498 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 269799007499 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 269799007500 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 269799007501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799007502 NAD(P) binding site [chemical binding]; other site 269799007503 active site 269799007504 SnoaL-like domain; Region: SnoaL_2; pfam12680 269799007505 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269799007506 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 269799007507 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 269799007508 CoenzymeA binding site [chemical binding]; other site 269799007509 subunit interaction site [polypeptide binding]; other site 269799007510 PHB binding site; other site 269799007511 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 269799007512 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 269799007513 putative NAD(P) binding site [chemical binding]; other site 269799007514 catalytic Zn binding site [ion binding]; other site 269799007515 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269799007516 classical (c) SDRs; Region: SDR_c; cd05233 269799007517 NAD(P) binding site [chemical binding]; other site 269799007518 active site 269799007519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 269799007520 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 269799007521 dimer interface [polypeptide binding]; other site 269799007522 metal binding site [ion binding]; metal-binding site 269799007523 substrate binding site [chemical binding]; other site 269799007524 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 269799007525 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 269799007526 active site 269799007527 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 269799007528 catalytic triad [active] 269799007529 dimer interface [polypeptide binding]; other site 269799007530 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 269799007531 4Fe-4S binding domain; Region: Fer4; pfam00037 269799007532 Transposase domain (DUF772); Region: DUF772; pfam05598 269799007533 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799007534 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 269799007535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799007536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799007537 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269799007538 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269799007539 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 269799007540 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 269799007541 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 269799007542 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799007543 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 269799007544 acyl-activating enzyme (AAE) consensus motif; other site 269799007545 acyl-activating enzyme (AAE) consensus motif; other site 269799007546 putative AMP binding site [chemical binding]; other site 269799007547 putative active site [active] 269799007548 putative CoA binding site [chemical binding]; other site 269799007549 palindrome; Gmet_R0112 269799007550 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 269799007551 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 269799007552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799007553 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269799007554 NAD(P) binding site [chemical binding]; other site 269799007555 active site 269799007556 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 269799007557 dimerization domain [polypeptide binding]; other site 269799007558 dimer interface [polypeptide binding]; other site 269799007559 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269799007560 catalytic residues [active] 269799007561 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 269799007562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799007563 AMP-binding domain protein; Validated; Region: PRK08315 269799007564 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799007565 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 269799007566 acyl-activating enzyme (AAE) consensus motif; other site 269799007567 putative AMP binding site [chemical binding]; other site 269799007568 putative active site [active] 269799007569 putative CoA binding site [chemical binding]; other site 269799007570 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 269799007571 CoenzymeA binding site [chemical binding]; other site 269799007572 subunit interaction site [polypeptide binding]; other site 269799007573 PHB binding site; other site 269799007574 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269799007575 diiron binding motif [ion binding]; other site 269799007576 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799007577 Cysteine-rich domain; Region: CCG; pfam02754 269799007578 Cysteine-rich domain; Region: CCG; pfam02754 269799007579 Homeodomain-like domain; Region: HTH_23; pfam13384 269799007580 Winged helix-turn helix; Region: HTH_29; pfam13551 269799007581 Integrase core domain; Region: rve; pfam00665 269799007582 4Fe-4S binding domain; Region: Fer4; pfam00037 269799007583 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799007584 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269799007585 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799007586 conserved nucleotide sequence; Gmet_R1020 269799007587 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799007588 Ligand binding site [chemical binding]; other site 269799007589 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799007590 primosome assembly protein PriA; Validated; Region: PRK05580 269799007591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4306 269799007592 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 269799007593 Transcriptional regulator [Transcription]; Region: IclR; COG1414 269799007594 Bacterial transcriptional regulator; Region: IclR; pfam01614 269799007595 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 269799007596 CoA binding domain; Region: CoA_binding; smart00881 269799007597 CoA-ligase; Region: Ligase_CoA; pfam00549 269799007598 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 269799007599 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 269799007600 CoA-ligase; Region: Ligase_CoA; pfam00549 269799007601 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799007602 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269799007603 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799007604 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799007605 Ligand binding site [chemical binding]; other site 269799007606 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799007607 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 269799007608 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799007609 4Fe-4S binding domain; Region: Fer4; cl02805 269799007610 Cysteine-rich domain; Region: CCG; pfam02754 269799007611 Cysteine-rich domain; Region: CCG; pfam02754 269799007612 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799007613 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269799007614 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799007615 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799007616 Ligand binding site [chemical binding]; other site 269799007617 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799007618 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799007619 4Fe-4S binding domain; Region: Fer4; cl02805 269799007620 Cysteine-rich domain; Region: CCG; pfam02754 269799007621 Cysteine-rich domain; Region: CCG; pfam02754 269799007622 putative acyltransferase; Provisional; Region: PRK05790 269799007623 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269799007624 dimer interface [polypeptide binding]; other site 269799007625 active site 269799007626 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 269799007627 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 269799007628 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 269799007629 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 269799007630 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799007631 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269799007632 active site 269799007633 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 269799007634 integrase Gmet_2271 5' region; Gmet_R0113 269799007635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 269799007636 Integrase core domain; Region: rve; pfam00665 269799007637 transposase/IS protein; Provisional; Region: PRK09183 269799007638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799007639 Walker A motif; other site 269799007640 ATP binding site [chemical binding]; other site 269799007641 Walker B motif; other site 269799007642 Replication initiation factor; Region: Rep_trans; pfam02486 269799007643 Helix-turn-helix domain; Region: HTH_17; pfam12728 269799007644 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 269799007645 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269799007646 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 269799007647 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269799007648 active site 269799007649 DNA binding site [nucleotide binding] 269799007650 Int/Topo IB signature motif; other site 269799007651 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 269799007652 active site 269799007653 Int/Topo IB signature motif; other site 269799007654 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 269799007655 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 269799007656 catalytic residues [active] 269799007657 catalytic nucleophile [active] 269799007658 Recombinase; Region: Recombinase; pfam07508 269799007659 NUMOD4 motif; Region: NUMOD4; pfam07463 269799007660 HNH endonuclease; Region: HNH_3; pfam13392 269799007661 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799007662 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799007663 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 269799007664 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 269799007665 active site 269799007666 NTP binding site [chemical binding]; other site 269799007667 metal binding triad [ion binding]; metal-binding site 269799007668 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 269799007669 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 269799007670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799007671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799007672 ATP binding site [chemical binding]; other site 269799007673 Mg2+ binding site [ion binding]; other site 269799007674 G-X-G motif; other site 269799007675 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 269799007676 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 269799007677 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 269799007678 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 269799007679 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 269799007680 phosphoglycolate phosphatase; Provisional; Region: PRK13222 269799007681 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 269799007682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799007683 motif II; other site 269799007684 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269799007685 Uncharacterized conserved protein [Function unknown]; Region: COG1633 269799007686 diiron binding motif [ion binding]; other site 269799007687 GMP synthase; Reviewed; Region: guaA; PRK00074 269799007688 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 269799007689 AMP/PPi binding site [chemical binding]; other site 269799007690 candidate oxyanion hole; other site 269799007691 catalytic triad [active] 269799007692 potential glutamine specificity residues [chemical binding]; other site 269799007693 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 269799007694 ATP Binding subdomain [chemical binding]; other site 269799007695 Ligand Binding sites [chemical binding]; other site 269799007696 Dimerization subdomain; other site 269799007697 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 269799007698 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 269799007699 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 269799007700 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 269799007701 active site 269799007702 conserved nucleotide sequence; Gmet_P2293 269799007703 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 269799007704 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 269799007705 oligomer interface [polypeptide binding]; other site 269799007706 active site 269799007707 metal binding site [ion binding]; metal-binding site 269799007708 Bifunctional nuclease; Region: DNase-RNase; pfam02577 269799007709 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 269799007710 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 269799007711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799007712 FeS/SAM binding site; other site 269799007713 TRAM domain; Region: TRAM; pfam01938 269799007714 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 269799007715 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 269799007716 DNA polymerase III, delta subunit; Region: holA; TIGR01128 269799007717 Lipopolysaccharide-assembly; Region: LptE; pfam04390 269799007718 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 269799007719 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 269799007720 HIGH motif; other site 269799007721 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 269799007722 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 269799007723 active site 269799007724 KMSKS motif; other site 269799007725 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 269799007726 tRNA binding surface [nucleotide binding]; other site 269799007727 conserved nucleotide sequence; Gmet_P2300 269799007728 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799007729 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799007730 heme-binding residues [chemical binding]; other site 269799007731 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799007732 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799007733 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799007734 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799007735 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799007736 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799007737 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799007738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799007739 active site 269799007740 phosphorylation site [posttranslational modification] 269799007741 intermolecular recognition site; other site 269799007742 dimerization interface [polypeptide binding]; other site 269799007743 GAF domain; Region: GAF_2; pfam13185 269799007744 GAF domain; Region: GAF_3; pfam13492 269799007745 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 269799007746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799007747 active site 269799007748 phosphorylation site [posttranslational modification] 269799007749 intermolecular recognition site; other site 269799007750 dimerization interface [polypeptide binding]; other site 269799007751 CheB methylesterase; Region: CheB_methylest; pfam01339 269799007752 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269799007753 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 269799007754 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269799007755 HEAT repeats; Region: HEAT_2; pfam13646 269799007756 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 269799007757 HEAT repeats; Region: HEAT_2; pfam13646 269799007758 HEAT repeats; Region: HEAT_2; pfam13646 269799007759 HEAT repeats; Region: HEAT_2; pfam13646 269799007760 HEAT repeats; Region: HEAT_2; pfam13646 269799007761 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 269799007762 Response regulator receiver domain; Region: Response_reg; pfam00072 269799007763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799007764 active site 269799007765 phosphorylation site [posttranslational modification] 269799007766 intermolecular recognition site; other site 269799007767 dimerization interface [polypeptide binding]; other site 269799007768 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 269799007769 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 269799007770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799007771 Walker A motif; other site 269799007772 ATP binding site [chemical binding]; other site 269799007773 Walker B motif; other site 269799007774 arginine finger; other site 269799007775 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269799007776 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 269799007777 putative binding surface; other site 269799007778 active site 269799007779 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 269799007780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799007781 ATP binding site [chemical binding]; other site 269799007782 Mg2+ binding site [ion binding]; other site 269799007783 G-X-G motif; other site 269799007784 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 269799007785 Response regulator receiver domain; Region: Response_reg; pfam00072 269799007786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799007787 active site 269799007788 phosphorylation site [posttranslational modification] 269799007789 intermolecular recognition site; other site 269799007790 dimerization interface [polypeptide binding]; other site 269799007791 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 269799007792 GTP-binding protein Der; Reviewed; Region: PRK00093 269799007793 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 269799007794 G1 box; other site 269799007795 GTP/Mg2+ binding site [chemical binding]; other site 269799007796 Switch I region; other site 269799007797 G2 box; other site 269799007798 Switch II region; other site 269799007799 G3 box; other site 269799007800 G4 box; other site 269799007801 G5 box; other site 269799007802 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 269799007803 G1 box; other site 269799007804 GTP/Mg2+ binding site [chemical binding]; other site 269799007805 Switch I region; other site 269799007806 G2 box; other site 269799007807 G3 box; other site 269799007808 Switch II region; other site 269799007809 G4 box; other site 269799007810 G5 box; other site 269799007811 GTPase Era; Reviewed; Region: era; PRK00089 269799007812 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 269799007813 G1 box; other site 269799007814 GTP/Mg2+ binding site [chemical binding]; other site 269799007815 Switch I region; other site 269799007816 G2 box; other site 269799007817 Switch II region; other site 269799007818 G3 box; other site 269799007819 G4 box; other site 269799007820 G5 box; other site 269799007821 KH domain; Region: KH_2; pfam07650 269799007822 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 269799007823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799007824 FeS/SAM binding site; other site 269799007825 ribonuclease III; Reviewed; Region: rnc; PRK00102 269799007826 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 269799007827 dimerization interface [polypeptide binding]; other site 269799007828 active site 269799007829 metal binding site [ion binding]; metal-binding site 269799007830 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 269799007831 dsRNA binding site [nucleotide binding]; other site 269799007832 thymidylate kinase; Validated; Region: tmk; PRK00698 269799007833 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 269799007834 TMP-binding site; other site 269799007835 ATP-binding site [chemical binding]; other site 269799007836 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 269799007837 DNA polymerase III subunit delta'; Validated; Region: PRK08485 269799007838 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 269799007839 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 269799007840 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 269799007841 active site 269799007842 HIGH motif; other site 269799007843 KMSKS motif; other site 269799007844 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 269799007845 tRNA binding surface [nucleotide binding]; other site 269799007846 anticodon binding site; other site 269799007847 Uncharacterized conserved protein [Function unknown]; Region: COG1434 269799007848 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 269799007849 putative active site [active] 269799007850 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 269799007851 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 269799007852 homotrimer interaction site [polypeptide binding]; other site 269799007853 putative active site [active] 269799007854 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 269799007855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799007856 Zn2+ binding site [ion binding]; other site 269799007857 Mg2+ binding site [ion binding]; other site 269799007858 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 269799007859 synthetase active site [active] 269799007860 NTP binding site [chemical binding]; other site 269799007861 metal binding site [ion binding]; metal-binding site 269799007862 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 269799007863 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 269799007864 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 269799007865 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 269799007866 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 269799007867 catalytic site [active] 269799007868 G-X2-G-X-G-K; other site 269799007869 four heptanucleotide repeats; Gmet_H422 269799007870 hypothetical protein; Provisional; Region: PRK11820 269799007871 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 269799007872 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 269799007873 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 269799007874 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 269799007875 NAD binding site [chemical binding]; other site 269799007876 homodimer interface [polypeptide binding]; other site 269799007877 active site 269799007878 substrate binding site [chemical binding]; other site 269799007879 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 269799007880 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269799007881 putative NAD(P) binding site [chemical binding]; other site 269799007882 active site 269799007883 putative substrate binding site [chemical binding]; other site 269799007884 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 269799007885 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269799007886 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269799007887 putative active site [active] 269799007888 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 269799007889 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 269799007890 inhibitor-cofactor binding pocket; inhibition site 269799007891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799007892 catalytic residue [active] 269799007893 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 269799007894 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 269799007895 putative trimer interface [polypeptide binding]; other site 269799007896 putative CoA binding site [chemical binding]; other site 269799007897 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 269799007898 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 269799007899 Ligand binding site; other site 269799007900 metal-binding site 269799007901 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 269799007902 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269799007903 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 269799007904 active site 269799007905 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 269799007906 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 269799007907 acetyl-CoA synthetase; Provisional; Region: PRK04319 269799007908 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 269799007909 active site 269799007910 acyl-activating enzyme (AAE) consensus motif; other site 269799007911 putative CoA binding site [chemical binding]; other site 269799007912 AMP binding site [chemical binding]; other site 269799007913 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 269799007914 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269799007915 putative active site [active] 269799007916 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 269799007917 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 269799007918 Probable Catalytic site; other site 269799007919 metal-binding site 269799007920 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 269799007921 GDP-Fucose binding site [chemical binding]; other site 269799007922 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269799007923 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 269799007924 putative metal binding site; other site 269799007925 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 269799007926 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269799007927 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269799007928 putative active site [active] 269799007929 Uncharacterized conserved protein [Function unknown]; Region: COG2835 269799007930 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 269799007931 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 269799007932 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 269799007933 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 269799007934 four heptanucleotide repeats; Gmet_H423 269799007935 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269799007936 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269799007937 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 269799007938 Walker A/P-loop; other site 269799007939 ATP binding site [chemical binding]; other site 269799007940 Q-loop/lid; other site 269799007941 ABC transporter signature motif; other site 269799007942 Walker B; other site 269799007943 D-loop; other site 269799007944 H-loop/switch region; other site 269799007945 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 269799007946 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 269799007947 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 269799007948 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 269799007949 inhibitor-cofactor binding pocket; inhibition site 269799007950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799007951 catalytic residue [active] 269799007952 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 269799007953 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 269799007954 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 269799007955 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 269799007956 active site 269799007957 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 269799007958 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 269799007959 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 269799007960 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 269799007961 trimer interface [polypeptide binding]; other site 269799007962 active site 269799007963 UDP-GlcNAc binding site [chemical binding]; other site 269799007964 lipid binding site [chemical binding]; lipid-binding site 269799007965 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 269799007966 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269799007967 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 269799007968 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269799007969 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269799007970 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269799007971 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269799007972 Surface antigen; Region: Bac_surface_Ag; pfam01103 269799007973 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269799007974 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269799007975 Walker A/P-loop; other site 269799007976 ATP binding site [chemical binding]; other site 269799007977 Q-loop/lid; other site 269799007978 ABC transporter signature motif; other site 269799007979 Walker B; other site 269799007980 D-loop; other site 269799007981 H-loop/switch region; other site 269799007982 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 269799007983 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269799007984 FtsX-like permease family; Region: FtsX; pfam02687 269799007985 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 269799007986 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 269799007987 dimer interface [polypeptide binding]; other site 269799007988 putative anticodon binding site; other site 269799007989 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 269799007990 motif 1; other site 269799007991 active site 269799007992 motif 2; other site 269799007993 motif 3; other site 269799007994 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 269799007995 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 269799007996 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 269799007997 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269799007998 EVE domain; Region: EVE; pfam01878 269799007999 Uncharacterized conserved protein [Function unknown]; Region: COG4198 269799008000 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 269799008001 Sporulation related domain; Region: SPOR; pfam05036 269799008002 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 269799008003 NlpC/P60 family; Region: NLPC_P60; pfam00877 269799008004 peptide chain release factor 2; Validated; Region: prfB; PRK00578 269799008005 This domain is found in peptide chain release factors; Region: PCRF; smart00937 269799008006 RF-1 domain; Region: RF-1; pfam00472 269799008007 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 269799008008 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 269799008009 putative active site [active] 269799008010 catalytic triad [active] 269799008011 putative dimer interface [polypeptide binding]; other site 269799008012 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 269799008013 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 269799008014 Transporter associated domain; Region: CorC_HlyC; smart01091 269799008015 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 269799008016 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 269799008017 active site 269799008018 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 269799008019 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 269799008020 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 269799008021 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 269799008022 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799008023 Zn2+ binding site [ion binding]; other site 269799008024 Mg2+ binding site [ion binding]; other site 269799008025 enolase; Provisional; Region: eno; PRK00077 269799008026 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 269799008027 dimer interface [polypeptide binding]; other site 269799008028 metal binding site [ion binding]; metal-binding site 269799008029 substrate binding pocket [chemical binding]; other site 269799008030 conserved palindrome; Gmet_R0114 269799008031 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 269799008032 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 269799008033 active site 269799008034 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 269799008035 Isochorismatase family; Region: Isochorismatase; pfam00857 269799008036 catalytic triad [active] 269799008037 metal binding site [ion binding]; metal-binding site 269799008038 conserved cis-peptide bond; other site 269799008039 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 269799008040 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 269799008041 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799008042 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799008043 Staphylococcal nuclease homologues; Region: SNc; smart00318 269799008044 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 269799008045 Catalytic site; other site 269799008046 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 269799008047 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 269799008048 ligand binding site [chemical binding]; other site 269799008049 NAD binding site [chemical binding]; other site 269799008050 dimerization interface [polypeptide binding]; other site 269799008051 catalytic site [active] 269799008052 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 269799008053 putative L-serine binding site [chemical binding]; other site 269799008054 conserved nucleotide sequence; Gmet_P2378 269799008055 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 269799008056 TIGR03987 family protein; Region: TIGR03987 269799008057 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 269799008058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799008059 Zn2+ binding site [ion binding]; other site 269799008060 Mg2+ binding site [ion binding]; other site 269799008061 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 269799008062 intersubunit interface [polypeptide binding]; other site 269799008063 active site 269799008064 zinc binding site [ion binding]; other site 269799008065 Na+ binding site [ion binding]; other site 269799008066 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 269799008067 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 269799008068 active site residue [active] 269799008069 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 269799008070 Rhomboid family; Region: Rhomboid; pfam01694 269799008071 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799008072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799008073 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799008074 conserved nucleotide sequence; Gmet_R0115 269799008075 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 269799008076 Protein of unknown function, DUF479; Region: DUF479; cl01203 269799008077 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 269799008078 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 269799008079 homodimer interface [polypeptide binding]; other site 269799008080 substrate-cofactor binding pocket; other site 269799008081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799008082 catalytic residue [active] 269799008083 4-alpha-glucanotransferase; Provisional; Region: PRK14508 269799008084 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 269799008085 FtsH Extracellular; Region: FtsH_ext; pfam06480 269799008086 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 269799008087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799008088 Walker B motif; other site 269799008089 arginine finger; other site 269799008090 Peptidase family M41; Region: Peptidase_M41; pfam01434 269799008091 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 269799008092 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 269799008093 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 269799008094 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799008095 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 269799008096 L-aspartate oxidase; Provisional; Region: PRK06175 269799008097 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 269799008098 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 269799008099 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse...; Region: SQR_QFR_TypeB_TM; cd03526 269799008100 Iron-sulfur protein interface; other site 269799008101 proximal heme binding site [chemical binding]; other site 269799008102 distal heme binding site [chemical binding]; other site 269799008103 dimer interface [polypeptide binding]; other site 269799008104 conserved nucleotide sequence; Gmet_R0116 269799008105 conserved nucleotide sequence; Gmet_R0117 269799008106 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 269799008107 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 269799008108 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 269799008109 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 269799008110 homodimer interface [polypeptide binding]; other site 269799008111 metal binding site [ion binding]; metal-binding site 269799008112 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 269799008113 homodimer interface [polypeptide binding]; other site 269799008114 active site 269799008115 putative chemical substrate binding site [chemical binding]; other site 269799008116 metal binding site [ion binding]; metal-binding site 269799008117 conserved nucleotide sequence; Gmet_R0118 269799008118 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 269799008119 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 269799008120 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 269799008121 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 269799008122 catalytic residues [active] 269799008123 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 269799008124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799008125 binding surface 269799008126 TPR motif; other site 269799008127 TPR repeat; Region: TPR_11; pfam13414 269799008128 TPR repeat; Region: TPR_11; pfam13414 269799008129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799008130 binding surface 269799008131 TPR motif; other site 269799008132 TPR repeat; Region: TPR_11; pfam13414 269799008133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799008134 binding surface 269799008135 TPR motif; other site 269799008136 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799008137 GAF domain; Region: GAF; pfam01590 269799008138 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 269799008139 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 269799008140 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269799008141 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269799008142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269799008143 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 269799008144 FtsX-like permease family; Region: FtsX; pfam02687 269799008145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269799008146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269799008147 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269799008148 Walker A/P-loop; other site 269799008149 ATP binding site [chemical binding]; other site 269799008150 Q-loop/lid; other site 269799008151 ABC transporter signature motif; other site 269799008152 Walker B; other site 269799008153 D-loop; other site 269799008154 H-loop/switch region; other site 269799008155 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 269799008156 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799008157 intracellular protease, PfpI family; Region: PfpI; TIGR01382 269799008158 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 269799008159 proposed catalytic triad [active] 269799008160 conserved cys residue [active] 269799008161 conserved palindrome; Gmet_R5007 269799008162 superoxide dismutase; Provisional; Region: PRK10543 269799008163 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 269799008164 Protein of unknown function (DUF503); Region: DUF503; pfam04456 269799008165 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 269799008166 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 269799008167 putative dimer interface [polypeptide binding]; other site 269799008168 putative anticodon binding site; other site 269799008169 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 269799008170 homodimer interface [polypeptide binding]; other site 269799008171 motif 1; other site 269799008172 motif 2; other site 269799008173 active site 269799008174 motif 3; other site 269799008175 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 269799008176 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 269799008177 catalytic residues [active] 269799008178 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 269799008179 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 269799008180 putative active site [active] 269799008181 YdjC motif; other site 269799008182 Mg binding site [ion binding]; other site 269799008183 putative homodimer interface [polypeptide binding]; other site 269799008184 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 269799008185 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 269799008186 B12 binding site [chemical binding]; other site 269799008187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799008188 FeS/SAM binding site; other site 269799008189 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269799008190 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 269799008191 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 269799008192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008193 active site 269799008194 phosphorylation site [posttranslational modification] 269799008195 intermolecular recognition site; other site 269799008196 dimerization interface [polypeptide binding]; other site 269799008197 CheB methylesterase; Region: CheB_methylest; pfam01339 269799008198 CheD chemotactic sensory transduction; Region: CheD; cl00810 269799008199 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269799008200 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 269799008201 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269799008202 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 269799008203 putative CheA interaction surface; other site 269799008204 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799008205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799008206 dimerization interface [polypeptide binding]; other site 269799008207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799008208 PAS domain; Region: PAS_9; pfam13426 269799008209 putative active site [active] 269799008210 heme pocket [chemical binding]; other site 269799008211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799008212 PAS domain; Region: PAS_9; pfam13426 269799008213 putative active site [active] 269799008214 heme pocket [chemical binding]; other site 269799008215 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799008216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799008217 dimer interface [polypeptide binding]; other site 269799008218 putative CheW interface [polypeptide binding]; other site 269799008219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799008220 dimerization interface [polypeptide binding]; other site 269799008221 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799008222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799008223 dimer interface [polypeptide binding]; other site 269799008224 putative CheW interface [polypeptide binding]; other site 269799008225 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799008226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799008227 dimerization interface [polypeptide binding]; other site 269799008228 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799008229 dimer interface [polypeptide binding]; other site 269799008230 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 269799008231 putative CheW interface [polypeptide binding]; other site 269799008232 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799008233 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799008234 metal binding site [ion binding]; metal-binding site 269799008235 active site 269799008236 I-site; other site 269799008237 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 269799008238 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799008239 dimerization interface [polypeptide binding]; other site 269799008240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799008241 dimer interface [polypeptide binding]; other site 269799008242 phosphorylation site [posttranslational modification] 269799008243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008244 ATP binding site [chemical binding]; other site 269799008245 Mg2+ binding site [ion binding]; other site 269799008246 G-X-G motif; other site 269799008247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008248 Response regulator receiver domain; Region: Response_reg; pfam00072 269799008249 active site 269799008250 phosphorylation site [posttranslational modification] 269799008251 intermolecular recognition site; other site 269799008252 dimerization interface [polypeptide binding]; other site 269799008253 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 269799008254 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269799008255 putative binding surface; other site 269799008256 active site 269799008257 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 269799008258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008259 ATP binding site [chemical binding]; other site 269799008260 Mg2+ binding site [ion binding]; other site 269799008261 G-X-G motif; other site 269799008262 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 269799008263 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799008264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008265 active site 269799008266 phosphorylation site [posttranslational modification] 269799008267 intermolecular recognition site; other site 269799008268 dimerization interface [polypeptide binding]; other site 269799008269 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 269799008270 anti sigma factor interaction site; other site 269799008271 regulatory phosphorylation site [posttranslational modification]; other site 269799008272 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799008273 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799008274 dimer interface [polypeptide binding]; other site 269799008275 putative CheW interface [polypeptide binding]; other site 269799008276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008277 Response regulator receiver domain; Region: Response_reg; pfam00072 269799008278 active site 269799008279 phosphorylation site [posttranslational modification] 269799008280 intermolecular recognition site; other site 269799008281 dimerization interface [polypeptide binding]; other site 269799008282 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 269799008283 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 269799008284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269799008285 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 269799008286 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 269799008287 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 269799008288 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 269799008289 Ligand Binding Site [chemical binding]; other site 269799008290 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 269799008291 GAF domain; Region: GAF_3; pfam13492 269799008292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799008293 dimer interface [polypeptide binding]; other site 269799008294 phosphorylation site [posttranslational modification] 269799008295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008296 ATP binding site [chemical binding]; other site 269799008297 Mg2+ binding site [ion binding]; other site 269799008298 G-X-G motif; other site 269799008299 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 269799008300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008301 active site 269799008302 phosphorylation site [posttranslational modification] 269799008303 intermolecular recognition site; other site 269799008304 dimerization interface [polypeptide binding]; other site 269799008305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269799008306 DNA binding site [nucleotide binding] 269799008307 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 269799008308 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 269799008309 Walker A/P-loop; other site 269799008310 ATP binding site [chemical binding]; other site 269799008311 Q-loop/lid; other site 269799008312 ABC transporter signature motif; other site 269799008313 Walker B; other site 269799008314 D-loop; other site 269799008315 H-loop/switch region; other site 269799008316 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 269799008317 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 269799008318 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 269799008319 PDGLE domain; Region: PDGLE; pfam13190 269799008320 conserved nucleotide sequence; Gmet_R7006 269799008321 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 269799008322 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 269799008323 FeoA domain; Region: FeoA; pfam04023 269799008324 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 269799008325 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 269799008326 G1 box; other site 269799008327 GTP/Mg2+ binding site [chemical binding]; other site 269799008328 Switch I region; other site 269799008329 G2 box; other site 269799008330 G3 box; other site 269799008331 Switch II region; other site 269799008332 G4 box; other site 269799008333 G5 box; other site 269799008334 Nucleoside recognition; Region: Gate; pfam07670 269799008335 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 269799008336 Nucleoside recognition; Region: Gate; pfam07670 269799008337 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 269799008338 metal binding site 2 [ion binding]; metal-binding site 269799008339 putative DNA binding helix; other site 269799008340 metal binding site 1 [ion binding]; metal-binding site 269799008341 dimer interface [polypeptide binding]; other site 269799008342 structural Zn2+ binding site [ion binding]; other site 269799008343 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 269799008344 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 269799008345 Major royal jelly protein; Region: MRJP; pfam03022 269799008346 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 269799008347 active site 269799008348 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 269799008349 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 269799008350 octanucleotide repeats; Gmet_R0154 269799008351 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 269799008352 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269799008353 catalytic residues [active] 269799008354 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799008355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008356 active site 269799008357 phosphorylation site [posttranslational modification] 269799008358 intermolecular recognition site; other site 269799008359 dimerization interface [polypeptide binding]; other site 269799008360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799008361 Walker A motif; other site 269799008362 ATP binding site [chemical binding]; other site 269799008363 Walker B motif; other site 269799008364 arginine finger; other site 269799008365 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799008366 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 269799008367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799008368 dimer interface [polypeptide binding]; other site 269799008369 phosphorylation site [posttranslational modification] 269799008370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008371 ATP binding site [chemical binding]; other site 269799008372 Mg2+ binding site [ion binding]; other site 269799008373 G-X-G motif; other site 269799008374 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 269799008375 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 269799008376 substrate binding pocket [chemical binding]; other site 269799008377 chain length determination region; other site 269799008378 substrate-Mg2+ binding site; other site 269799008379 catalytic residues [active] 269799008380 aspartate-rich region 1; other site 269799008381 active site lid residues [active] 269799008382 aspartate-rich region 2; other site 269799008383 Uncharacterized conserved protein [Function unknown]; Region: COG0398 269799008384 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 269799008385 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 269799008386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799008387 FeS/SAM binding site; other site 269799008388 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 269799008389 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 269799008390 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 269799008391 active site 269799008392 dimer interface [polypeptide binding]; other site 269799008393 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 269799008394 dimer interface [polypeptide binding]; other site 269799008395 active site 269799008396 CHASE domain; Region: CHASE; pfam03924 269799008397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008398 ATP binding site [chemical binding]; other site 269799008399 Mg2+ binding site [ion binding]; other site 269799008400 G-X-G motif; other site 269799008401 conserved nucleotide sequence; Gmet_P2462 269799008402 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 269799008403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799008404 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 269799008405 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 269799008406 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 269799008407 active site 269799008408 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 269799008409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799008410 FeS/SAM binding site; other site 269799008411 conserved nucleotide sequence; Gmet_P2465 269799008412 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 269799008413 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 269799008414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799008415 Walker A motif; other site 269799008416 ATP binding site [chemical binding]; other site 269799008417 Walker B motif; other site 269799008418 arginine finger; other site 269799008419 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 269799008420 putative active site [active] 269799008421 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 269799008422 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 269799008423 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 269799008424 Interdomain contacts; other site 269799008425 Cytokine receptor motif; other site 269799008426 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 269799008427 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 269799008428 Interdomain contacts; other site 269799008429 Cytokine receptor motif; other site 269799008430 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 269799008431 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 269799008432 Interdomain contacts; other site 269799008433 Cytokine receptor motif; other site 269799008434 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 269799008435 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 269799008436 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 269799008437 Interdomain contacts; other site 269799008438 Cytokine receptor motif; other site 269799008439 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 269799008440 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 269799008441 Interdomain contacts; other site 269799008442 Cytokine receptor motif; other site 269799008443 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 269799008444 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 269799008445 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799008446 Cupin domain; Region: Cupin_2; cl17218 269799008447 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 269799008448 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 269799008449 NADP binding site [chemical binding]; other site 269799008450 active site 269799008451 putative substrate binding site [chemical binding]; other site 269799008452 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 269799008453 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 269799008454 NAD binding site [chemical binding]; other site 269799008455 substrate binding site [chemical binding]; other site 269799008456 homodimer interface [polypeptide binding]; other site 269799008457 active site 269799008458 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 269799008459 OstA-like protein; Region: OstA; cl00844 269799008460 Organic solvent tolerance protein; Region: OstA_C; pfam04453 269799008461 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 269799008462 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 269799008463 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 269799008464 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 269799008465 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 269799008466 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 269799008467 substrate binding site [chemical binding]; other site 269799008468 active site 269799008469 catalytic residues [active] 269799008470 heterodimer interface [polypeptide binding]; other site 269799008471 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799008472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799008473 dimerization interface [polypeptide binding]; other site 269799008474 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799008475 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799008476 dimer interface [polypeptide binding]; other site 269799008477 putative CheW interface [polypeptide binding]; other site 269799008478 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 269799008479 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 269799008480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799008481 Walker A/P-loop; other site 269799008482 ATP binding site [chemical binding]; other site 269799008483 Q-loop/lid; other site 269799008484 ABC transporter signature motif; other site 269799008485 Walker B; other site 269799008486 D-loop; other site 269799008487 H-loop/switch region; other site 269799008488 ABC transporter; Region: ABC_tran_2; pfam12848 269799008489 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799008490 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 269799008491 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269799008492 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269799008493 catalytic residue [active] 269799008494 conserved nucleotide sequence; Gmet_P2481 269799008495 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 269799008496 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 269799008497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799008498 catalytic residue [active] 269799008499 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 269799008500 dimer interface [polypeptide binding]; other site 269799008501 conserved nucleotide sequence; Gmet_P2483 269799008502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799008503 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799008504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799008505 S-adenosylmethionine binding site [chemical binding]; other site 269799008506 conserved nucleotide sequence; Gmet_R9001 269799008507 Transposase domain (DUF772); Region: DUF772; pfam05598 269799008508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799008509 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 269799008510 conserved nucleotide sequence; Gmet_R0119 269799008511 conserved nucleotide sequence; Gmet_R9002 269799008512 Restriction endonuclease; Region: Mrr_cat; pfam04471 269799008513 conserved nucleotide sequence; Gmet_R9003 269799008514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799008515 non-specific DNA binding site [nucleotide binding]; other site 269799008516 salt bridge; other site 269799008517 sequence-specific DNA binding site [nucleotide binding]; other site 269799008518 conserved nucleotide sequence; Gmet_P2491 269799008519 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 269799008520 active site 269799008521 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 269799008522 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 269799008523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799008524 catalytic residue [active] 269799008525 'integration host factor binding site, putative; Gmet_I117A' 269799008526 'integration host factor binding site, putative; Gmet_I117B' 269799008527 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 269799008528 active site 269799008529 ribulose/triose binding site [chemical binding]; other site 269799008530 phosphate binding site [ion binding]; other site 269799008531 substrate (anthranilate) binding pocket [chemical binding]; other site 269799008532 product (indole) binding pocket [chemical binding]; other site 269799008533 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 269799008534 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 269799008535 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 269799008536 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 269799008537 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 269799008538 glutamine binding [chemical binding]; other site 269799008539 catalytic triad [active] 269799008540 anthranilate synthase component I; Provisional; Region: PRK13565 269799008541 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 269799008542 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 269799008543 heat shock protein 90; Provisional; Region: PRK05218 269799008544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008545 ATP binding site [chemical binding]; other site 269799008546 Mg2+ binding site [ion binding]; other site 269799008547 G-X-G motif; other site 269799008548 Cytochrome P450; Region: p450; cl12078 269799008549 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 269799008550 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 269799008551 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 269799008552 PemK-like protein; Region: PemK; pfam02452 269799008553 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 269799008554 Rhomboid family; Region: Rhomboid; cl11446 269799008555 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799008556 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799008557 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799008558 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 269799008559 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 269799008560 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 269799008561 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 269799008562 TPP-binding site [chemical binding]; other site 269799008563 tetramer interface [polypeptide binding]; other site 269799008564 heterodimer interface [polypeptide binding]; other site 269799008565 phosphorylation loop region [posttranslational modification] 269799008566 'integration host factor binding site, putative; Gmet_I209A' 269799008567 'integration host factor binding site, putative; Gmet_I209B' 269799008568 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 269799008569 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 269799008570 alpha subunit interface [polypeptide binding]; other site 269799008571 TPP binding site [chemical binding]; other site 269799008572 heterodimer interface [polypeptide binding]; other site 269799008573 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269799008574 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 269799008575 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269799008576 E3 interaction surface; other site 269799008577 lipoyl attachment site [posttranslational modification]; other site 269799008578 e3 binding domain; Region: E3_binding; pfam02817 269799008579 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 269799008580 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 269799008581 dockerin binding interface; other site 269799008582 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 269799008583 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799008584 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799008585 Hemerythrin-like domain; Region: Hr-like; cd12108 269799008586 Fe binding site [ion binding]; other site 269799008587 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 269799008588 'integration host factor binding site, putative; Gmet_I118A' 269799008589 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 269799008590 'integration host factor binding site, putative; Gmet_I118B' 269799008591 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269799008592 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269799008593 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799008594 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 269799008595 precorrin-3B synthase; Region: CobG; TIGR02435 269799008596 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 269799008597 elongation factor G; Reviewed; Region: PRK13351 269799008598 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 269799008599 G1 box; other site 269799008600 putative GEF interaction site [polypeptide binding]; other site 269799008601 GTP/Mg2+ binding site [chemical binding]; other site 269799008602 Switch I region; other site 269799008603 G2 box; other site 269799008604 G3 box; other site 269799008605 Switch II region; other site 269799008606 G4 box; other site 269799008607 G5 box; other site 269799008608 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 269799008609 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 269799008610 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 269799008611 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 269799008612 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 269799008613 PilZ domain; Region: PilZ; pfam07238 269799008614 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 269799008615 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799008616 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799008617 ABC transporter; Region: ABC_tran_2; pfam12848 269799008618 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799008619 Staphylococcal nuclease homologues; Region: SNc; smart00318 269799008620 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 269799008621 Catalytic site; other site 269799008622 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269799008623 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269799008624 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269799008625 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269799008626 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269799008627 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269799008628 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799008629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799008630 S-adenosylmethionine binding site [chemical binding]; other site 269799008631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799008632 active site 269799008633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799008634 S-adenosylmethionine binding site [chemical binding]; other site 269799008635 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 269799008636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799008637 non-specific DNA binding site [nucleotide binding]; other site 269799008638 salt bridge; other site 269799008639 sequence-specific DNA binding site [nucleotide binding]; other site 269799008640 conserved nucleotide sequence fragment; Gmet_R9004 269799008641 conserved palindrome; Gmet_R0155 269799008642 transposase/IS protein; Provisional; Region: PRK09183 269799008643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799008644 Walker A motif; other site 269799008645 ATP binding site [chemical binding]; other site 269799008646 Walker B motif; other site 269799008647 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 269799008648 Integrase core domain; Region: rve; pfam00665 269799008649 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 269799008650 ATP binding site [chemical binding]; other site 269799008651 Mg2+ binding site [ion binding]; other site 269799008652 G-X-G motif; other site 269799008653 conserved nucleotide sequence; Gmet_P2540 269799008654 conserved palindrome; Gmet_R0156 269799008655 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 269799008656 mce related protein; Region: MCE; pfam02470 269799008657 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 269799008658 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 269799008659 Walker A/P-loop; other site 269799008660 ATP binding site [chemical binding]; other site 269799008661 Q-loop/lid; other site 269799008662 ABC transporter signature motif; other site 269799008663 Walker B; other site 269799008664 D-loop; other site 269799008665 H-loop/switch region; other site 269799008666 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 269799008667 Permease; Region: Permease; pfam02405 269799008668 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 269799008669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799008670 Walker A motif; other site 269799008671 ATP binding site [chemical binding]; other site 269799008672 Walker B motif; other site 269799008673 arginine finger; other site 269799008674 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 269799008675 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 269799008676 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799008677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799008678 ABC transporter; Region: ABC_tran_2; pfam12848 269799008679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799008680 ABC transporter; Region: ABC_tran_2; pfam12848 269799008681 four heptanucleotide repeats; Gmet_H424 269799008682 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 269799008683 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 269799008684 homodimer interface [polypeptide binding]; other site 269799008685 oligonucleotide binding site [chemical binding]; other site 269799008686 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 269799008687 Predicted permease [General function prediction only]; Region: COG2985 269799008688 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 269799008689 TrkA-C domain; Region: TrkA_C; pfam02080 269799008690 TrkA-C domain; Region: TrkA_C; pfam02080 269799008691 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 269799008692 Smr domain; Region: Smr; pfam01713 269799008693 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799008694 ligand binding site [chemical binding]; other site 269799008695 Protein of unknown function (DUF401); Region: DUF401; cl00830 269799008696 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 269799008697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799008698 binding surface 269799008699 TPR motif; other site 269799008700 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269799008701 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269799008702 catalytic residue [active] 269799008703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799008704 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 269799008705 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799008706 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 269799008707 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 269799008708 HflX GTPase family; Region: HflX; cd01878 269799008709 G1 box; other site 269799008710 GTP/Mg2+ binding site [chemical binding]; other site 269799008711 Switch I region; other site 269799008712 G2 box; other site 269799008713 G3 box; other site 269799008714 Switch II region; other site 269799008715 G4 box; other site 269799008716 G5 box; other site 269799008717 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 269799008718 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 269799008719 NAD binding site [chemical binding]; other site 269799008720 homotetramer interface [polypeptide binding]; other site 269799008721 homodimer interface [polypeptide binding]; other site 269799008722 substrate binding site [chemical binding]; other site 269799008723 active site 269799008724 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799008725 GAF domain; Region: GAF_3; pfam13492 269799008726 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 269799008727 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799008728 Zn2+ binding site [ion binding]; other site 269799008729 Mg2+ binding site [ion binding]; other site 269799008730 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 269799008731 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 269799008732 FMN binding site [chemical binding]; other site 269799008733 active site 269799008734 catalytic residues [active] 269799008735 substrate binding site [chemical binding]; other site 269799008736 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269799008737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799008738 putative active site [active] 269799008739 heme pocket [chemical binding]; other site 269799008740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008741 ATP binding site [chemical binding]; other site 269799008742 Mg2+ binding site [ion binding]; other site 269799008743 G-X-G motif; other site 269799008744 four heptanucleotide repeats; Gmet_H425 269799008745 four heptanucleotide repeats; Gmet_H426 269799008746 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799008747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008748 active site 269799008749 phosphorylation site [posttranslational modification] 269799008750 intermolecular recognition site; other site 269799008751 dimerization interface [polypeptide binding]; other site 269799008752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799008753 Walker A motif; other site 269799008754 ATP binding site [chemical binding]; other site 269799008755 Walker B motif; other site 269799008756 arginine finger; other site 269799008757 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 269799008758 four heptanucleotide repeats; Gmet_H427 269799008759 four heptanucleotide repeats; Gmet_H428 269799008760 Isochorismatase family; Region: Isochorismatase; pfam00857 269799008761 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 269799008762 catalytic triad [active] 269799008763 dimer interface [polypeptide binding]; other site 269799008764 conserved cis-peptide bond; other site 269799008765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799008766 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799008767 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799008768 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 269799008769 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 269799008770 active site 269799008771 replicative DNA helicase; Region: DnaB; TIGR00665 269799008772 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 269799008773 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 269799008774 Walker A motif; other site 269799008775 ATP binding site [chemical binding]; other site 269799008776 Walker B motif; other site 269799008777 DNA binding loops [nucleotide binding] 269799008778 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 269799008779 fumarate hydratase; Provisional; Region: PRK15389 269799008780 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 269799008781 Fumarase C-terminus; Region: Fumerase_C; pfam05683 269799008782 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 269799008783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799008784 Walker A motif; other site 269799008785 ATP binding site [chemical binding]; other site 269799008786 Walker B motif; other site 269799008787 Trm112p-like protein; Region: Trm112p; pfam03966 269799008788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269799008789 'integration host factor binding site, putative; Gmet_I210A' 269799008790 'integration host factor binding site, putative; Gmet_I210B' 269799008791 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 269799008792 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 269799008793 ATP binding site [chemical binding]; other site 269799008794 Mg++ binding site [ion binding]; other site 269799008795 motif III; other site 269799008796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799008797 nucleotide binding region [chemical binding]; other site 269799008798 ATP-binding site [chemical binding]; other site 269799008799 Helix-turn-helix domain; Region: HTH_17; pfam12728 269799008800 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 269799008801 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 269799008802 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 269799008803 active site 269799008804 FMN binding site [chemical binding]; other site 269799008805 substrate binding site [chemical binding]; other site 269799008806 homotetramer interface [polypeptide binding]; other site 269799008807 catalytic residue [active] 269799008808 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 269799008809 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 269799008810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799008811 Walker A/P-loop; other site 269799008812 ATP binding site [chemical binding]; other site 269799008813 Q-loop/lid; other site 269799008814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799008815 ABC transporter signature motif; other site 269799008816 Walker B; other site 269799008817 D-loop; other site 269799008818 H-loop/switch region; other site 269799008819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799008820 Walker A/P-loop; other site 269799008821 ATP binding site [chemical binding]; other site 269799008822 Q-loop/lid; other site 269799008823 ABC transporter signature motif; other site 269799008824 Walker B; other site 269799008825 D-loop; other site 269799008826 H-loop/switch region; other site 269799008827 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 269799008828 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 269799008829 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 269799008830 conserved nucleotide sequence; Gmet_I407 269799008831 conserved nucleotide sequence; Gmet_I408 269799008832 conserved nucleotide sequence; Gmet_I409 269799008833 Mechanosensitive ion channel; Region: MS_channel; pfam00924 269799008834 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 269799008835 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 269799008836 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 269799008837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 269799008838 Integrase core domain; Region: rve; pfam00665 269799008839 transposase/IS protein; Provisional; Region: PRK09183 269799008840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799008841 Walker A motif; other site 269799008842 ATP binding site [chemical binding]; other site 269799008843 Walker B motif; other site 269799008844 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 269799008845 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 269799008846 HicB family; Region: HicB; pfam05534 269799008847 Homeodomain-like domain; Region: HTH_23; pfam13384 269799008848 Winged helix-turn helix; Region: HTH_29; pfam13551 269799008849 Integrase core domain; Region: rve; pfam00665 269799008850 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 269799008851 active site 269799008852 catalytic triad [active] 269799008853 oxyanion hole [active] 269799008854 hydrogenase 4 subunit H; Validated; Region: PRK08222 269799008855 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 269799008856 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 269799008857 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 269799008858 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 269799008859 hydrogenase 4 subunit F; Validated; Region: PRK06458 269799008860 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799008861 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 269799008862 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 269799008863 NADH dehydrogenase; Region: NADHdh; cl00469 269799008864 hydrogenase 4 subunit B; Validated; Region: PRK06521 269799008865 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799008866 PemK-like protein; Region: PemK; pfam02452 269799008867 Helix-turn-helix domain; Region: HTH_17; pfam12728 269799008868 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 269799008869 active site 269799008870 phosphorylation site [posttranslational modification] 269799008871 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 269799008872 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 269799008873 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 269799008874 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 269799008875 Flagellin N-methylase; Region: FliB; pfam03692 269799008876 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 269799008877 RNA polymerase factor sigma-70; Validated; Region: PRK09047 269799008878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269799008879 DNA binding residues [nucleotide binding] 269799008880 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 269799008881 non-heme iron binding site [ion binding]; other site 269799008882 tetramer interface [polypeptide binding]; other site 269799008883 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799008884 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799008885 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 269799008886 active site 269799008887 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 269799008888 RNAase interaction site [polypeptide binding]; other site 269799008889 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 269799008890 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 269799008891 putative active site [active] 269799008892 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 269799008893 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 269799008894 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 269799008895 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 269799008896 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 269799008897 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 269799008898 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 269799008899 Tetratricopeptide repeat; Region: TPR_6; pfam13174 269799008900 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 269799008901 putative dimer interface [polypeptide binding]; other site 269799008902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 269799008903 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 269799008904 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 269799008905 putative active site [active] 269799008906 catalytic site [active] 269799008907 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 269799008908 putative active site [active] 269799008909 catalytic site [active] 269799008910 PAS domain S-box; Region: sensory_box; TIGR00229 269799008911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799008912 putative active site [active] 269799008913 heme pocket [chemical binding]; other site 269799008914 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799008915 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799008916 metal binding site [ion binding]; metal-binding site 269799008917 active site 269799008918 I-site; other site 269799008919 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269799008920 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 269799008921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799008922 Walker A/P-loop; other site 269799008923 ATP binding site [chemical binding]; other site 269799008924 Q-loop/lid; other site 269799008925 ABC transporter signature motif; other site 269799008926 Walker B; other site 269799008927 D-loop; other site 269799008928 H-loop/switch region; other site 269799008929 ABC transporter; Region: ABC_tran_2; pfam12848 269799008930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 269799008931 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 269799008932 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 269799008933 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 269799008934 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 269799008935 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269799008936 Walker A/P-loop; other site 269799008937 ATP binding site [chemical binding]; other site 269799008938 Q-loop/lid; other site 269799008939 ABC transporter signature motif; other site 269799008940 Walker B; other site 269799008941 D-loop; other site 269799008942 H-loop/switch region; other site 269799008943 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 269799008944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799008945 Walker A/P-loop; other site 269799008946 ATP binding site [chemical binding]; other site 269799008947 Q-loop/lid; other site 269799008948 ABC transporter signature motif; other site 269799008949 Walker B; other site 269799008950 D-loop; other site 269799008951 H-loop/switch region; other site 269799008952 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 269799008953 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 269799008954 putative dimer interface [polypeptide binding]; other site 269799008955 Protein of unknown function, DUF606; Region: DUF606; pfam04657 269799008956 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 269799008957 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 269799008958 active site 269799008959 substrate-binding site [chemical binding]; other site 269799008960 metal-binding site [ion binding] 269799008961 GTP binding site [chemical binding]; other site 269799008962 Response regulator receiver domain; Region: Response_reg; pfam00072 269799008963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008964 active site 269799008965 phosphorylation site [posttranslational modification] 269799008966 intermolecular recognition site; other site 269799008967 dimerization interface [polypeptide binding]; other site 269799008968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799008969 dimer interface [polypeptide binding]; other site 269799008970 phosphorylation site [posttranslational modification] 269799008971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008972 ATP binding site [chemical binding]; other site 269799008973 Mg2+ binding site [ion binding]; other site 269799008974 G-X-G motif; other site 269799008975 CheB methylesterase; Region: CheB_methylest; pfam01339 269799008976 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 269799008977 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269799008978 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799008979 GAF domain; Region: GAF_2; pfam13185 269799008980 GAF domain; Region: GAF; pfam01590 269799008981 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 269799008982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799008983 ATP binding site [chemical binding]; other site 269799008984 Mg2+ binding site [ion binding]; other site 269799008985 G-X-G motif; other site 269799008986 Response regulator receiver domain; Region: Response_reg; pfam00072 269799008987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008988 active site 269799008989 phosphorylation site [posttranslational modification] 269799008990 intermolecular recognition site; other site 269799008991 dimerization interface [polypeptide binding]; other site 269799008992 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799008993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799008994 active site 269799008995 phosphorylation site [posttranslational modification] 269799008996 intermolecular recognition site; other site 269799008997 dimerization interface [polypeptide binding]; other site 269799008998 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799008999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009000 active site 269799009001 phosphorylation site [posttranslational modification] 269799009002 intermolecular recognition site; other site 269799009003 dimerization interface [polypeptide binding]; other site 269799009004 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 269799009005 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 269799009006 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 269799009007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799009008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799009009 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 269799009010 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 269799009011 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 269799009012 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 269799009013 Cupin domain; Region: Cupin_2; cl17218 269799009014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 269799009015 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 269799009016 active site 269799009017 metal binding site [ion binding]; metal-binding site 269799009018 conserved nucleotide sequence; Gmet_R0120 269799009019 phosphodiesterase YaeI; Provisional; Region: PRK11340 269799009020 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 269799009021 putative active site [active] 269799009022 putative metal binding site [ion binding]; other site 269799009023 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 269799009024 protein binding site [polypeptide binding]; other site 269799009025 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 269799009026 catalytic residues [active] 269799009027 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 269799009028 protein binding site [polypeptide binding]; other site 269799009029 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 269799009030 catalytic residues [active] 269799009031 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799009032 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799009033 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799009034 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 269799009035 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269799009036 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 269799009037 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799009038 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799009039 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799009040 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 269799009041 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799009042 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799009043 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799009044 Ankyrin repeat; Region: Ank; pfam00023 269799009045 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799009046 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799009047 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799009048 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799009049 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269799009050 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269799009051 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 269799009052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 269799009053 TPR repeat; Region: TPR_11; pfam13414 269799009054 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 269799009055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799009056 FeS/SAM binding site; other site 269799009057 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 269799009058 BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; Region: KU; cd00109 269799009059 trypsin interaction site; other site 269799009060 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 269799009061 AAA domain; Region: AAA_14; pfam13173 269799009062 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 269799009063 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 269799009064 CoenzymeA binding site [chemical binding]; other site 269799009065 subunit interaction site [polypeptide binding]; other site 269799009066 PHB binding site; other site 269799009067 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 269799009068 Fe-S cluster binding site [ion binding]; other site 269799009069 active site 269799009070 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 269799009071 'integration host factor binding site, putative; Gmet_I304A' 269799009072 'integration host factor binding site, putative; Gmet_I304B' 269799009073 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 269799009074 Flavoprotein; Region: Flavoprotein; pfam02441 269799009075 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 269799009076 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 269799009077 'integration host factor binding site, putative; Gmet_I211A' 269799009078 'integration host factor binding site, putative; Gmet_I211B' 269799009079 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 269799009080 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 269799009081 generic binding surface II; other site 269799009082 generic binding surface I; other site 269799009083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799009084 Zn2+ binding site [ion binding]; other site 269799009085 Mg2+ binding site [ion binding]; other site 269799009086 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 269799009087 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 269799009088 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009090 active site 269799009091 phosphorylation site [posttranslational modification] 269799009092 intermolecular recognition site; other site 269799009093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799009094 dimerization interface [polypeptide binding]; other site 269799009095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009096 dimer interface [polypeptide binding]; other site 269799009097 phosphorylation site [posttranslational modification] 269799009098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009099 ATP binding site [chemical binding]; other site 269799009100 Mg2+ binding site [ion binding]; other site 269799009101 G-X-G motif; other site 269799009102 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269799009103 Ligand Binding Site [chemical binding]; other site 269799009104 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009106 active site 269799009107 phosphorylation site [posttranslational modification] 269799009108 intermolecular recognition site; other site 269799009109 dimerization interface [polypeptide binding]; other site 269799009110 GAF domain; Region: GAF; pfam01590 269799009111 GAF domain; Region: GAF_2; pfam13185 269799009112 Helix-turn-helix domain; Region: HTH_25; pfam13413 269799009113 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 269799009114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799009115 binding surface 269799009116 TPR motif; other site 269799009117 TPR repeat; Region: TPR_11; pfam13414 269799009118 TPR repeat; Region: TPR_11; pfam13414 269799009119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799009120 binding surface 269799009121 TPR motif; other site 269799009122 TPR repeat; Region: TPR_11; pfam13414 269799009123 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 269799009124 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 269799009125 substrate binding site [chemical binding]; other site 269799009126 ATP binding site [chemical binding]; other site 269799009127 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 269799009128 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14463 269799009129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799009130 FeS/SAM binding site; other site 269799009131 conserved nucleotide sequence; Gmet_P2685 269799009132 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 269799009133 active site 269799009134 multimer interface [polypeptide binding]; other site 269799009135 palindrome; Gmet_R0121 269799009136 AMMECR1; Region: AMMECR1; pfam01871 269799009137 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 269799009138 palindrome; Gmet_R0122 269799009139 Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS...; Region: ScCS-like; cd06103 269799009140 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 269799009141 dimer interface [polypeptide binding]; other site 269799009142 active site 269799009143 coenzyme A binding site [chemical binding]; other site 269799009144 citrylCoA binding site [chemical binding]; other site 269799009145 oxalacetate/citrate binding site [chemical binding]; other site 269799009146 catalytic triad [active] 269799009147 conserved nucleotide sequence; Gmet_P2689 269799009148 conserved nucleotide sequence; Gmet_R0123 269799009149 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 269799009150 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 269799009151 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 269799009152 active site 269799009153 AMP-binding domain protein; Validated; Region: PRK08315 269799009154 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 269799009155 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 269799009156 acyl-activating enzyme (AAE) consensus motif; other site 269799009157 putative AMP binding site [chemical binding]; other site 269799009158 putative active site [active] 269799009159 putative CoA binding site [chemical binding]; other site 269799009160 conserved nucleotide sequence; Gmet_R0124 269799009161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269799009162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009163 active site 269799009164 phosphorylation site [posttranslational modification] 269799009165 intermolecular recognition site; other site 269799009166 dimerization interface [polypeptide binding]; other site 269799009167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269799009168 DNA binding site [nucleotide binding] 269799009169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799009170 dimerization interface [polypeptide binding]; other site 269799009171 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 269799009172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799009173 putative active site [active] 269799009174 heme pocket [chemical binding]; other site 269799009175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009176 dimer interface [polypeptide binding]; other site 269799009177 phosphorylation site [posttranslational modification] 269799009178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009179 ATP binding site [chemical binding]; other site 269799009180 Mg2+ binding site [ion binding]; other site 269799009181 G-X-G motif; other site 269799009182 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 269799009183 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 269799009184 putative ligand binding site [chemical binding]; other site 269799009185 putative NAD binding site [chemical binding]; other site 269799009186 catalytic site [active] 269799009187 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 269799009188 Carbon starvation protein CstA; Region: CstA; pfam02554 269799009189 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 269799009190 conserved nucleotide sequence; Gmet_R0125 269799009191 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 269799009192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 269799009193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009194 active site 269799009195 phosphorylation site [posttranslational modification] 269799009196 intermolecular recognition site; other site 269799009197 dimerization interface [polypeptide binding]; other site 269799009198 LytTr DNA-binding domain; Region: LytTR; smart00850 269799009199 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 269799009200 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 269799009201 GAF domain; Region: GAF_3; pfam13492 269799009202 Histidine kinase; Region: His_kinase; pfam06580 269799009203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009204 ATP binding site [chemical binding]; other site 269799009205 Mg2+ binding site [ion binding]; other site 269799009206 G-X-G motif; other site 269799009207 Protein of unknown function (DUF502); Region: DUF502; cl01107 269799009208 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 269799009209 PBP superfamily domain; Region: PBP_like_2; cl17296 269799009210 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 269799009211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799009212 ABC-ATPase subunit interface; other site 269799009213 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 269799009214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269799009215 dimer interface [polypeptide binding]; other site 269799009216 conserved gate region; other site 269799009217 putative PBP binding loops; other site 269799009218 ABC-ATPase subunit interface; other site 269799009219 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14256 269799009220 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 269799009221 Walker A/P-loop; other site 269799009222 ATP binding site [chemical binding]; other site 269799009223 Q-loop/lid; other site 269799009224 ABC transporter signature motif; other site 269799009225 Walker B; other site 269799009226 D-loop; other site 269799009227 H-loop/switch region; other site 269799009228 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 269799009229 PhoU domain; Region: PhoU; pfam01895 269799009230 PhoU domain; Region: PhoU; pfam01895 269799009231 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 269799009232 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 269799009233 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269799009234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799009235 TPR motif; other site 269799009236 TPR repeat; Region: TPR_11; pfam13414 269799009237 binding surface 269799009238 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 269799009239 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799009240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799009241 dimerization interface [polypeptide binding]; other site 269799009242 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799009243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799009244 dimer interface [polypeptide binding]; other site 269799009245 putative CheW interface [polypeptide binding]; other site 269799009246 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269799009247 putative binding surface; other site 269799009248 active site 269799009249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009250 ATP binding site [chemical binding]; other site 269799009251 Mg2+ binding site [ion binding]; other site 269799009252 G-X-G motif; other site 269799009253 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 269799009254 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799009255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009256 active site 269799009257 phosphorylation site [posttranslational modification] 269799009258 intermolecular recognition site; other site 269799009259 dimerization interface [polypeptide binding]; other site 269799009260 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 269799009261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009262 active site 269799009263 phosphorylation site [posttranslational modification] 269799009264 intermolecular recognition site; other site 269799009265 dimerization interface [polypeptide binding]; other site 269799009266 CheB methylesterase; Region: CheB_methylest; pfam01339 269799009267 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009269 active site 269799009270 phosphorylation site [posttranslational modification] 269799009271 intermolecular recognition site; other site 269799009272 dimerization interface [polypeptide binding]; other site 269799009273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009274 dimer interface [polypeptide binding]; other site 269799009275 phosphorylation site [posttranslational modification] 269799009276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009277 ATP binding site [chemical binding]; other site 269799009278 Mg2+ binding site [ion binding]; other site 269799009279 G-X-G motif; other site 269799009280 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 269799009281 C-terminal peptidase (prc); Region: prc; TIGR00225 269799009282 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 269799009283 protein binding site [polypeptide binding]; other site 269799009284 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 269799009285 Catalytic dyad [active] 269799009286 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799009287 Zn2+ binding site [ion binding]; other site 269799009288 Mg2+ binding site [ion binding]; other site 269799009289 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 269799009290 conserved nucleotide sequence; Gmet_I410 269799009291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269799009292 active site 269799009293 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 269799009294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269799009295 ATP binding site [chemical binding]; other site 269799009296 putative Mg++ binding site [ion binding]; other site 269799009297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799009298 nucleotide binding region [chemical binding]; other site 269799009299 ATP-binding site [chemical binding]; other site 269799009300 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 269799009301 HRDC domain; Region: HRDC; pfam00570 269799009302 Uncharacterized conserved protein [Function unknown]; Region: COG1262 269799009303 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 269799009304 conserved nucleotide sequence; Gmet_R7007 269799009305 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 269799009306 Sensory domain found in PocR; Region: PocR; pfam10114 269799009307 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799009308 GAF domain; Region: GAF_2; pfam13185 269799009309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799009310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799009311 metal binding site [ion binding]; metal-binding site 269799009312 active site 269799009313 I-site; other site 269799009314 conserved nucleotide sequence; Gmet_I411 269799009315 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 269799009316 substrate binding site [chemical binding]; other site 269799009317 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 269799009318 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 269799009319 dimer interface [polypeptide binding]; other site 269799009320 decamer (pentamer of dimers) interface [polypeptide binding]; other site 269799009321 catalytic triad [active] 269799009322 peroxidatic and resolving cysteines [active] 269799009323 'integration host factor binding site, putative; Gmet_I212A' 269799009324 'integration host factor binding site, putative; Gmet_I212B' 269799009325 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 269799009326 Part of AAA domain; Region: AAA_19; pfam13245 269799009327 Family description; Region: UvrD_C_2; pfam13538 269799009328 conserved nucleotide sequence; Gmet_R0126 269799009329 conserved nucleotide sequence; Gmet_R0127 269799009330 Predicted metalloprotease [General function prediction only]; Region: COG2321 269799009331 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 269799009332 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 269799009333 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269799009334 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799009335 ligand binding site [chemical binding]; other site 269799009336 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 269799009337 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 269799009338 nucleotide binding pocket [chemical binding]; other site 269799009339 K-X-D-G motif; other site 269799009340 catalytic site [active] 269799009341 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 269799009342 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 269799009343 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 269799009344 Dimer interface [polypeptide binding]; other site 269799009345 BRCT sequence motif; other site 269799009346 acylphosphatase; Provisional; Region: PRK14438 269799009347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799009348 Radical SAM superfamily; Region: Radical_SAM; pfam04055 269799009349 FeS/SAM binding site; other site 269799009350 Chromate transporter; Region: Chromate_transp; pfam02417 269799009351 Chromate transporter; Region: Chromate_transp; pfam02417 269799009352 AAA domain; Region: AAA_26; pfam13500 269799009353 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799009354 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 269799009355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799009356 FeS/SAM binding site; other site 269799009357 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 269799009358 conserved nucleotide sequence; Gmet_I412 269799009359 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 269799009360 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 269799009361 N-terminal plug; other site 269799009362 ligand-binding site [chemical binding]; other site 269799009363 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 269799009364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799009365 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799009366 dimerization interface [polypeptide binding]; other site 269799009367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009368 dimer interface [polypeptide binding]; other site 269799009369 phosphorylation site [posttranslational modification] 269799009370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009371 ATP binding site [chemical binding]; other site 269799009372 Mg2+ binding site [ion binding]; other site 269799009373 G-X-G motif; other site 269799009374 'integration host factor binding site, putative; Gmet_I213A' 269799009375 'integration host factor binding site, putative; Gmet_I213B' 269799009376 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 269799009377 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 269799009378 putative [4Fe-4S] binding site [ion binding]; other site 269799009379 putative molybdopterin cofactor binding site [chemical binding]; other site 269799009380 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 269799009381 putative molybdopterin cofactor binding site; other site 269799009382 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 269799009383 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009385 active site 269799009386 phosphorylation site [posttranslational modification] 269799009387 intermolecular recognition site; other site 269799009388 dimerization interface [polypeptide binding]; other site 269799009389 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 269799009390 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 269799009391 Probable Catalytic site; other site 269799009392 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 269799009393 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 269799009394 palindrome; Gmet_R0128 269799009395 Bacterial Ig-like domain; Region: Big_5; pfam13205 269799009396 Bacterial Ig-like domain; Region: Big_5; pfam13205 269799009397 Bacterial Ig-like domain; Region: Big_5; pfam13205 269799009398 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 269799009399 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 269799009400 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 269799009401 AAA domain; Region: AAA_32; pfam13654 269799009402 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 269799009403 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 269799009404 GAF domain; Region: GAF_2; pfam13185 269799009405 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799009406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009407 dimer interface [polypeptide binding]; other site 269799009408 phosphorylation site [posttranslational modification] 269799009409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009410 ATP binding site [chemical binding]; other site 269799009411 Mg2+ binding site [ion binding]; other site 269799009412 G-X-G motif; other site 269799009413 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 269799009414 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 269799009415 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 269799009416 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 269799009417 B12 binding site [chemical binding]; other site 269799009418 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269799009419 E3 interaction surface; other site 269799009420 lipoyl attachment site [posttranslational modification]; other site 269799009421 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 269799009422 e3 binding domain; Region: E3_binding; pfam02817 269799009423 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 269799009424 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 269799009425 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 269799009426 alpha subunit interface [polypeptide binding]; other site 269799009427 TPP binding site [chemical binding]; other site 269799009428 heterodimer interface [polypeptide binding]; other site 269799009429 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269799009430 conserved nucleotide sequence; Gmet_P2753 269799009431 conserved nucleotide sequence; Gmet_R2003 269799009432 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 269799009433 Protein of unknown function (DUF523); Region: DUF523; pfam04463 269799009434 Uncharacterized conserved protein [Function unknown]; Region: COG3272 269799009435 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 269799009436 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 269799009437 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 269799009438 tetramer interface [polypeptide binding]; other site 269799009439 TPP-binding site [chemical binding]; other site 269799009440 heterodimer interface [polypeptide binding]; other site 269799009441 phosphorylation loop region [posttranslational modification] 269799009442 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 269799009443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009444 dimer interface [polypeptide binding]; other site 269799009445 phosphorylation site [posttranslational modification] 269799009446 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 269799009447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009448 dimer interface [polypeptide binding]; other site 269799009449 phosphorylation site [posttranslational modification] 269799009450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009451 ATP binding site [chemical binding]; other site 269799009452 Mg2+ binding site [ion binding]; other site 269799009453 G-X-G motif; other site 269799009454 aconitate hydratase; Validated; Region: PRK07229 269799009455 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 269799009456 substrate binding site [chemical binding]; other site 269799009457 ligand binding site [chemical binding]; other site 269799009458 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 269799009459 substrate binding site [chemical binding]; other site 269799009460 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 269799009461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269799009462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799009463 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 269799009464 four heptanucleotide repeats; Gmet_H429 269799009465 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 269799009466 Sel1-like repeats; Region: SEL1; smart00671 269799009467 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269799009468 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 269799009469 E3 interaction surface; other site 269799009470 lipoyl attachment site [posttranslational modification]; other site 269799009471 e3 binding domain; Region: E3_binding; pfam02817 269799009472 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 269799009473 four heptanucleotide repeats; Gmet_H430 269799009474 four heptanucleotide repeats; Gmet_H431 269799009475 four heptanucleotide repeats; Gmet_H432 269799009476 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 269799009477 homodimer interface [polypeptide binding]; other site 269799009478 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 269799009479 active site pocket [active] 269799009480 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 269799009481 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 269799009482 ligand binding site; other site 269799009483 oligomer interface; other site 269799009484 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 269799009485 dimer interface [polypeptide binding]; other site 269799009486 N-terminal domain interface [polypeptide binding]; other site 269799009487 sulfate 1 binding site; other site 269799009488 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 269799009489 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 269799009490 TPP-binding site [chemical binding]; other site 269799009491 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 269799009492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009493 dimer interface [polypeptide binding]; other site 269799009494 phosphorylation site [posttranslational modification] 269799009495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009496 ATP binding site [chemical binding]; other site 269799009497 Mg2+ binding site [ion binding]; other site 269799009498 G-X-G motif; other site 269799009499 PBP superfamily domain; Region: PBP_like_2; cl17296 269799009500 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269799009501 metal-binding site [ion binding] 269799009502 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 269799009503 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 269799009504 metal-binding site [ion binding] 269799009505 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269799009506 Soluble P-type ATPase [General function prediction only]; Region: COG4087 269799009507 Domain of unknown function DUF20; Region: UPF0118; pfam01594 269799009508 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 269799009509 Domain of unknown function DUF20; Region: UPF0118; pfam01594 269799009510 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 269799009511 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 269799009512 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 269799009513 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 269799009514 putative active site [active] 269799009515 putative metal binding site [ion binding]; other site 269799009516 four heptanucleotide repeats; Gmet_H433 269799009517 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 269799009518 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 269799009519 Predicted transcriptional regulator [Transcription]; Region: COG1959 269799009520 YtxH-like protein; Region: YtxH; pfam12732 269799009521 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 269799009522 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 269799009523 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 269799009524 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 269799009525 AAA domain; Region: AAA_26; pfam13500 269799009526 'integration host factor binding site, putative; Gmet_I119A' 269799009527 'integration host factor binding site, putative; Gmet_I119B' 269799009528 Predicted GTPase [General function prediction only]; Region: COG2403 269799009529 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269799009530 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 269799009531 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 269799009532 putative substrate binding site [chemical binding]; other site 269799009533 homodimer interface [polypeptide binding]; other site 269799009534 nucleotide binding site [chemical binding]; other site 269799009535 nucleotide binding site [chemical binding]; other site 269799009536 Uncharacterized conserved protein [Function unknown]; Region: COG1915 269799009537 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 269799009538 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 269799009539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 269799009540 substrate binding pocket [chemical binding]; other site 269799009541 membrane-bound complex binding site; other site 269799009542 hinge residues; other site 269799009543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009544 dimer interface [polypeptide binding]; other site 269799009545 phosphorylation site [posttranslational modification] 269799009546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009547 ATP binding site [chemical binding]; other site 269799009548 Mg2+ binding site [ion binding]; other site 269799009549 G-X-G motif; other site 269799009550 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799009551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009552 active site 269799009553 phosphorylation site [posttranslational modification] 269799009554 intermolecular recognition site; other site 269799009555 dimerization interface [polypeptide binding]; other site 269799009556 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009558 active site 269799009559 phosphorylation site [posttranslational modification] 269799009560 intermolecular recognition site; other site 269799009561 dimerization interface [polypeptide binding]; other site 269799009562 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 269799009563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009564 dimer interface [polypeptide binding]; other site 269799009565 phosphorylation site [posttranslational modification] 269799009566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009567 ATP binding site [chemical binding]; other site 269799009568 Mg2+ binding site [ion binding]; other site 269799009569 G-X-G motif; other site 269799009570 conserved nucleotide sequence; Gmet_R0130 269799009571 Methyltransferase domain; Region: Methyltransf_31; pfam13847 269799009572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799009573 S-adenosylmethionine binding site [chemical binding]; other site 269799009574 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 269799009575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269799009576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269799009577 DNA binding residues [nucleotide binding] 269799009578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799009579 S-adenosylmethionine binding site [chemical binding]; other site 269799009580 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799009581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799009582 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799009583 transposase/IS protein; Provisional; Region: PRK09183 269799009584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799009585 Walker A motif; other site 269799009586 ATP binding site [chemical binding]; other site 269799009587 Walker B motif; other site 269799009588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 269799009589 Integrase core domain; Region: rve; pfam00665 269799009590 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 269799009591 conserved nucleotide sequence; Gmet_P2799 269799009592 conserved nucleotide sequence; Gmet_P2800 269799009593 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 269799009594 integron integrase; Region: integrase_gron; TIGR02249 269799009595 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 269799009596 Int/Topo IB signature motif; other site 269799009597 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 269799009598 fructokinase; Reviewed; Region: PRK09557 269799009599 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 269799009600 nucleotide binding site [chemical binding]; other site 269799009601 translation initiation factor Sui1; Validated; Region: PRK06824 269799009602 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 269799009603 putative rRNA binding site [nucleotide binding]; other site 269799009604 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 269799009605 trimer interface [polypeptide binding]; other site 269799009606 putative Zn binding site [ion binding]; other site 269799009607 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 269799009608 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269799009609 Surface antigen; Region: Bac_surface_Ag; pfam01103 269799009610 Family of unknown function (DUF490); Region: DUF490; pfam04357 269799009611 'integration host factor binding site, putative; Gmet_I120A' 269799009612 'integration host factor binding site, putative; Gmet_I120B' 269799009613 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799009614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799009615 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799009616 Cache domain; Region: Cache_1; pfam02743 269799009617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799009618 dimerization interface [polypeptide binding]; other site 269799009619 PAS domain; Region: PAS_9; pfam13426 269799009620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009621 dimer interface [polypeptide binding]; other site 269799009622 phosphorylation site [posttranslational modification] 269799009623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009624 ATP binding site [chemical binding]; other site 269799009625 Mg2+ binding site [ion binding]; other site 269799009626 G-X-G motif; other site 269799009627 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 269799009628 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 269799009629 substrate binding site [chemical binding]; other site 269799009630 ATP binding site [chemical binding]; other site 269799009631 MAEBL; Provisional; Region: PTZ00121 269799009632 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 269799009633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799009634 active site 269799009635 motif I; other site 269799009636 motif II; other site 269799009637 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 269799009638 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 269799009639 ligand binding site; other site 269799009640 HEAT repeats; Region: HEAT_2; pfam13646 269799009641 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799009642 Zn2+ binding site [ion binding]; other site 269799009643 Mg2+ binding site [ion binding]; other site 269799009644 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009646 active site 269799009647 phosphorylation site [posttranslational modification] 269799009648 intermolecular recognition site; other site 269799009649 dimerization interface [polypeptide binding]; other site 269799009650 PAS domain S-box; Region: sensory_box; TIGR00229 269799009651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799009652 putative active site [active] 269799009653 heme pocket [chemical binding]; other site 269799009654 PAS domain; Region: PAS_9; pfam13426 269799009655 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799009656 putative active site [active] 269799009657 heme pocket [chemical binding]; other site 269799009658 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 269799009659 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 269799009660 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 269799009661 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 269799009662 four heptanucleotide repeats; Gmet_H434 269799009663 four heptanucleotide repeats; Gmet_H435 269799009664 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 269799009665 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 269799009666 Active site cavity [active] 269799009667 catalytic acid [active] 269799009668 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 269799009669 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 269799009670 putative NADP binding site [chemical binding]; other site 269799009671 putative substrate binding site [chemical binding]; other site 269799009672 active site 269799009673 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 269799009674 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 269799009675 TPP-binding site; other site 269799009676 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269799009677 PYR/PP interface [polypeptide binding]; other site 269799009678 dimer interface [polypeptide binding]; other site 269799009679 TPP binding site [chemical binding]; other site 269799009680 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269799009681 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 269799009682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799009683 FeS/SAM binding site; other site 269799009684 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 269799009685 PAS domain S-box; Region: sensory_box; TIGR00229 269799009686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799009687 putative active site [active] 269799009688 heme pocket [chemical binding]; other site 269799009689 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799009690 GAF domain; Region: GAF; pfam01590 269799009691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799009692 dimer interface [polypeptide binding]; other site 269799009693 phosphorylation site [posttranslational modification] 269799009694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799009695 ATP binding site [chemical binding]; other site 269799009696 Mg2+ binding site [ion binding]; other site 269799009697 G-X-G motif; other site 269799009698 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009700 active site 269799009701 phosphorylation site [posttranslational modification] 269799009702 intermolecular recognition site; other site 269799009703 dimerization interface [polypeptide binding]; other site 269799009704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 269799009705 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 269799009706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799009707 dimerization interface [polypeptide binding]; other site 269799009708 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799009709 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799009710 dimer interface [polypeptide binding]; other site 269799009711 putative CheW interface [polypeptide binding]; other site 269799009712 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 269799009713 CheB methylesterase; Region: CheB_methylest; pfam01339 269799009714 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799009716 active site 269799009717 phosphorylation site [posttranslational modification] 269799009718 intermolecular recognition site; other site 269799009719 dimerization interface [polypeptide binding]; other site 269799009720 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 269799009721 Tar ligand binding domain homologue; Region: TarH; pfam02203 269799009722 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269799009723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799009724 dimerization interface [polypeptide binding]; other site 269799009725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799009726 dimer interface [polypeptide binding]; other site 269799009727 putative CheW interface [polypeptide binding]; other site 269799009728 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 269799009729 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 269799009730 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 269799009731 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 269799009732 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 269799009733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799009734 S-adenosylmethionine binding site [chemical binding]; other site 269799009735 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 269799009736 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 269799009737 hybrid cluster protein; Provisional; Region: PRK05290 269799009738 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799009739 ACS interaction site; other site 269799009740 CODH interaction site; other site 269799009741 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 269799009742 hybrid metal cluster; other site 269799009743 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 269799009744 putative FMN binding site [chemical binding]; other site 269799009745 conserved nucleotide sequence fragment; Gmet_R4004 269799009746 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 269799009747 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 269799009748 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 269799009749 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 269799009750 RNA binding surface [nucleotide binding]; other site 269799009751 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 269799009752 active site 269799009753 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 269799009754 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799009755 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799009756 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 269799009757 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 269799009758 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 269799009759 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 269799009760 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 269799009761 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 269799009762 conserved nucleotide sequence; Gmet_P2844 269799009763 GTP-binding protein YchF; Reviewed; Region: PRK09601 269799009764 YchF GTPase; Region: YchF; cd01900 269799009765 G1 box; other site 269799009766 GTP/Mg2+ binding site [chemical binding]; other site 269799009767 Switch I region; other site 269799009768 G2 box; other site 269799009769 Switch II region; other site 269799009770 G3 box; other site 269799009771 G4 box; other site 269799009772 G5 box; other site 269799009773 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 269799009774 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 269799009775 putative active site [active] 269799009776 catalytic residue [active] 269799009777 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 269799009778 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 269799009779 5S rRNA interface [nucleotide binding]; other site 269799009780 CTC domain interface [polypeptide binding]; other site 269799009781 L16 interface [polypeptide binding]; other site 269799009782 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 269799009783 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 269799009784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269799009785 active site 269799009786 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614 269799009787 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 269799009788 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 269799009789 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 269799009790 NodB motif; other site 269799009791 putative active site [active] 269799009792 putative catalytic site [active] 269799009793 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 269799009794 Clp amino terminal domain; Region: Clp_N; pfam02861 269799009795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799009796 Walker A motif; other site 269799009797 ATP binding site [chemical binding]; other site 269799009798 Walker B motif; other site 269799009799 arginine finger; other site 269799009800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799009801 Walker A motif; other site 269799009802 ATP binding site [chemical binding]; other site 269799009803 Walker B motif; other site 269799009804 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 269799009805 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 269799009806 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 269799009807 homodimer interface [polypeptide binding]; other site 269799009808 substrate-cofactor binding pocket; other site 269799009809 catalytic residue [active] 269799009810 conserved nucleotide sequence; Gmet_P2854 269799009811 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 269799009812 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 269799009813 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269799009814 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269799009815 DNA binding residues [nucleotide binding] 269799009816 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 269799009817 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 269799009818 ATP binding site [chemical binding]; other site 269799009819 substrate interface [chemical binding]; other site 269799009820 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 269799009821 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 269799009822 transmembrane helices; other site 269799009823 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 269799009824 Active Sites [active] 269799009825 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 269799009826 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 269799009827 Active Sites [active] 269799009828 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 269799009829 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 269799009830 CysD dimerization site [polypeptide binding]; other site 269799009831 G1 box; other site 269799009832 putative GEF interaction site [polypeptide binding]; other site 269799009833 GTP/Mg2+ binding site [chemical binding]; other site 269799009834 Switch I region; other site 269799009835 G2 box; other site 269799009836 G3 box; other site 269799009837 Switch II region; other site 269799009838 G4 box; other site 269799009839 G5 box; other site 269799009840 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 269799009841 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 269799009842 Predicted methyltransferases [General function prediction only]; Region: COG0313 269799009843 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 269799009844 putative SAM binding site [chemical binding]; other site 269799009845 putative homodimer interface [polypeptide binding]; other site 269799009846 NAD synthetase; Provisional; Region: PRK13980 269799009847 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 269799009848 homodimer interface [polypeptide binding]; other site 269799009849 NAD binding pocket [chemical binding]; other site 269799009850 ATP binding pocket [chemical binding]; other site 269799009851 Mg binding site [ion binding]; other site 269799009852 active-site loop [active] 269799009853 Predicted amidohydrolase [General function prediction only]; Region: COG0388 269799009854 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 269799009855 putative active site [active] 269799009856 catalytic triad [active] 269799009857 putative dimer interface [polypeptide binding]; other site 269799009858 hypothetical protein; Provisional; Region: PRK14675 269799009859 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 269799009860 RNA/DNA hybrid binding site [nucleotide binding]; other site 269799009861 active site 269799009862 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 269799009863 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 269799009864 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 269799009865 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 269799009866 RimM N-terminal domain; Region: RimM; pfam01782 269799009867 PRC-barrel domain; Region: PRC; pfam05239 269799009868 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 269799009869 KH domain; Region: KH_4; pfam13083 269799009870 G-X-X-G motif; other site 269799009871 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 269799009872 signal recognition particle protein; Provisional; Region: PRK10867 269799009873 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 269799009874 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 269799009875 P loop; other site 269799009876 GTP binding site [chemical binding]; other site 269799009877 Signal peptide binding domain; Region: SRP_SPB; pfam02978 269799009878 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 269799009879 Protein of unknown function (DUF721); Region: DUF721; pfam05258 269799009880 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 269799009881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799009882 S-adenosylmethionine binding site [chemical binding]; other site 269799009883 Predicted integral membrane protein [Function unknown]; Region: COG5617 269799009884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799009885 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799009886 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269799009887 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 269799009888 Probable Catalytic site; other site 269799009889 metal-binding site 269799009890 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 269799009891 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 269799009892 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 269799009893 putative active site [active] 269799009894 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799009895 Methyltransferase domain; Region: Methyltransf_11; pfam08241 269799009896 S-adenosylmethionine binding site [chemical binding]; other site 269799009897 Transposase domain (DUF772); Region: DUF772; pfam05598 269799009898 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799009899 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 269799009900 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 269799009901 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 269799009902 Probable Catalytic site; other site 269799009903 metal-binding site 269799009904 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 269799009905 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 269799009906 putative metal binding site; other site 269799009907 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799009908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799009909 S-adenosylmethionine binding site [chemical binding]; other site 269799009910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 269799009911 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269799009912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799009913 S-adenosylmethionine binding site [chemical binding]; other site 269799009914 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 269799009915 putative DNA binding site [nucleotide binding]; other site 269799009916 dimerization interface [polypeptide binding]; other site 269799009917 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 269799009918 putative Zn2+ binding site [ion binding]; other site 269799009919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 269799009920 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 269799009921 four heptanucleotide repeats; Gmet_H436 269799009922 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 269799009923 four helix bundle protein; Region: TIGR02436 269799009924 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 269799009925 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 269799009926 Ligand binding site; other site 269799009927 Putative Catalytic site; other site 269799009928 DXD motif; other site 269799009929 four heptanucleotide repeats; Gmet_H437 269799009930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799009931 TPR motif; other site 269799009932 binding surface 269799009933 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 269799009934 active site 269799009935 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 269799009936 NHL repeat; Region: NHL; pfam01436 269799009937 Uncharacterized conserved protein [Function unknown]; Region: COG3391 269799009938 NHL repeat; Region: NHL; pfam01436 269799009939 four heptanucleotide repeats; Gmet_H438 269799009940 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 269799009941 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 269799009942 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 269799009943 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 269799009944 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 269799009945 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 269799009946 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 269799009947 ResB-like family; Region: ResB; pfam05140 269799009948 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 269799009949 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799009950 heme-binding residues [chemical binding]; other site 269799009951 AIR carboxylase; Region: AIRC; pfam00731 269799009952 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 269799009953 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 269799009954 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 269799009955 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 269799009956 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 269799009957 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 269799009958 purine monophosphate binding site [chemical binding]; other site 269799009959 dimer interface [polypeptide binding]; other site 269799009960 putative catalytic residues [active] 269799009961 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 269799009962 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 269799009963 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 269799009964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799009965 four heptanucleotide repeats; Gmet_H439 269799009966 selenophosphate synthetase; Provisional; Region: PRK00943 269799009967 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 269799009968 dimerization interface [polypeptide binding]; other site 269799009969 putative ATP binding site [chemical binding]; other site 269799009970 alanine racemase; Reviewed; Region: alr; PRK00053 269799009971 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 269799009972 active site 269799009973 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269799009974 dimer interface [polypeptide binding]; other site 269799009975 substrate binding site [chemical binding]; other site 269799009976 catalytic residues [active] 269799009977 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 269799009978 thiamine phosphate binding site [chemical binding]; other site 269799009979 active site 269799009980 pyrophosphate binding site [ion binding]; other site 269799009981 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 269799009982 substrate binding site [chemical binding]; other site 269799009983 dimer interface [polypeptide binding]; other site 269799009984 ATP binding site [chemical binding]; other site 269799009985 four heptanucleotide repeats; Gmet_H440 269799009986 conserved nucleotide sequence; Gmet_R0132 269799009987 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 269799009988 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 269799009989 FAD binding domain; Region: FAD_binding_2; pfam00890 269799009990 L-aspartate oxidase; Provisional; Region: PRK06175 269799009991 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799009992 catalytic loop [active] 269799009993 iron binding site [ion binding]; other site 269799009994 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799009995 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 269799009996 Response regulator receiver domain; Region: Response_reg; pfam00072 269799009997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 269799009998 active site 269799009999 phosphorylation site [posttranslational modification] 269799010000 intermolecular recognition site; other site 269799010001 dimerization interface [polypeptide binding]; other site 269799010002 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 269799010003 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 269799010004 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 269799010005 active site 269799010006 catalytic site [active] 269799010007 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 269799010008 catalytic residues [active] 269799010009 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 269799010010 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 269799010011 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 269799010012 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 269799010013 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269799010014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799010015 dimerization interface [polypeptide binding]; other site 269799010016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799010017 dimer interface [polypeptide binding]; other site 269799010018 phosphorylation site [posttranslational modification] 269799010019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799010020 ATP binding site [chemical binding]; other site 269799010021 Mg2+ binding site [ion binding]; other site 269799010022 G-X-G motif; other site 269799010023 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799010024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010025 active site 269799010026 phosphorylation site [posttranslational modification] 269799010027 intermolecular recognition site; other site 269799010028 dimerization interface [polypeptide binding]; other site 269799010029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799010030 Walker A motif; other site 269799010031 ATP binding site [chemical binding]; other site 269799010032 Walker B motif; other site 269799010033 arginine finger; other site 269799010034 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799010035 Response regulator receiver domain; Region: Response_reg; pfam00072 269799010036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010037 active site 269799010038 phosphorylation site [posttranslational modification] 269799010039 intermolecular recognition site; other site 269799010040 dimerization interface [polypeptide binding]; other site 269799010041 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 269799010042 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 269799010043 palindrome; Gmet_R0133 269799010044 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799010045 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799010046 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799010047 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 269799010048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799010049 dimerization interface [polypeptide binding]; other site 269799010050 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269799010051 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 269799010052 thiS-thiF/thiG interaction site; other site 269799010053 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 269799010054 ThiS interaction site; other site 269799010055 putative active site [active] 269799010056 tetramer interface [polypeptide binding]; other site 269799010057 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 269799010058 thiamine phosphate binding site [chemical binding]; other site 269799010059 active site 269799010060 pyrophosphate binding site [ion binding]; other site 269799010061 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 269799010062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799010063 FeS/SAM binding site; other site 269799010064 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 269799010065 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 269799010066 conserved nucleotide sequence; Gmet_R0135 269799010067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799010068 dimerization interface [polypeptide binding]; other site 269799010069 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799010070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799010071 dimer interface [polypeptide binding]; other site 269799010072 putative CheW interface [polypeptide binding]; other site 269799010073 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269799010074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799010075 dimerization interface [polypeptide binding]; other site 269799010076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799010077 dimer interface [polypeptide binding]; other site 269799010078 putative CheW interface [polypeptide binding]; other site 269799010079 pyruvate phosphate dikinase; Provisional; Region: PRK09279 269799010080 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 269799010081 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269799010082 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269799010083 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 269799010084 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 269799010085 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 269799010086 dimer interface [polypeptide binding]; other site 269799010087 motif 1; other site 269799010088 active site 269799010089 motif 2; other site 269799010090 motif 3; other site 269799010091 Recombination protein O N terminal; Region: RecO_N; pfam11967 269799010092 DNA repair protein RecO; Region: reco; TIGR00613 269799010093 Recombination protein O C terminal; Region: RecO_C; pfam02565 269799010094 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 269799010095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010096 binding surface 269799010097 TPR motif; other site 269799010098 TPR repeat; Region: TPR_11; pfam13414 269799010099 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 269799010100 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 269799010101 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 269799010102 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 269799010103 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 269799010104 folate binding site [chemical binding]; other site 269799010105 NADP+ binding site [chemical binding]; other site 269799010106 carbon starvation protein A; Provisional; Region: PRK15015 269799010107 Carbon starvation protein CstA; Region: CstA; pfam02554 269799010108 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 269799010109 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 269799010110 EamA-like transporter family; Region: EamA; cl17759 269799010111 EamA-like transporter family; Region: EamA; cl17759 269799010112 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 269799010113 Isochorismatase family; Region: Isochorismatase; pfam00857 269799010114 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 269799010115 catalytic triad [active] 269799010116 conserved cis-peptide bond; other site 269799010117 Flavodoxin domain; Region: Flavodoxin_5; cl17428 269799010118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799010119 S-adenosylmethionine binding site [chemical binding]; other site 269799010120 PAS domain; Region: PAS_9; pfam13426 269799010121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799010122 putative active site [active] 269799010123 heme pocket [chemical binding]; other site 269799010124 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799010125 GAF domain; Region: GAF; pfam01590 269799010126 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799010127 GAF domain; Region: GAF; pfam01590 269799010128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799010129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799010130 dimer interface [polypeptide binding]; other site 269799010131 phosphorylation site [posttranslational modification] 269799010132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799010133 ATP binding site [chemical binding]; other site 269799010134 Mg2+ binding site [ion binding]; other site 269799010135 G-X-G motif; other site 269799010136 Flagellin N-methylase; Region: FliB; cl00497 269799010137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269799010138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799010139 S-adenosylmethionine binding site [chemical binding]; other site 269799010140 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 269799010141 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 269799010142 catalytic residues [active] 269799010143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 269799010144 conserved nucleotide sequence; Gmet_R0178 269799010145 conserved nucleotide sequence; Gmet_R2004 269799010146 Predicted transcriptional regulator [Transcription]; Region: COG4190 269799010147 MarR family; Region: MarR_2; cl17246 269799010148 Methyltransferase domain; Region: Methyltransf_31; pfam13847 269799010149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799010150 S-adenosylmethionine binding site [chemical binding]; other site 269799010151 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 269799010152 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799010153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799010154 FeS/SAM binding site; other site 269799010155 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 269799010156 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 269799010157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799010158 non-specific DNA binding site [nucleotide binding]; other site 269799010159 salt bridge; other site 269799010160 sequence-specific DNA binding site [nucleotide binding]; other site 269799010161 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 269799010162 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 269799010163 MutS domain III; Region: MutS_III; pfam05192 269799010164 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 269799010165 Walker A/P-loop; other site 269799010166 ATP binding site [chemical binding]; other site 269799010167 Q-loop/lid; other site 269799010168 ABC transporter signature motif; other site 269799010169 Walker B; other site 269799010170 D-loop; other site 269799010171 H-loop/switch region; other site 269799010172 Smr domain; Region: Smr; pfam01713 269799010173 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799010174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799010175 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799010176 'integration host factor binding site, putative; Gmet_I121A' 269799010177 'integration host factor binding site, putative; Gmet_I121B' 269799010178 RF-1 domain; Region: RF-1; pfam00472 269799010179 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269799010180 EamA-like transporter family; Region: EamA; pfam00892 269799010181 EamA-like transporter family; Region: EamA; pfam00892 269799010182 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 269799010183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799010184 S-adenosylmethionine binding site [chemical binding]; other site 269799010185 'integration host factor binding site, putative; Gmet_I214A' 269799010186 'integration host factor binding site, putative; Gmet_I214B' 269799010187 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799010188 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 269799010189 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 269799010190 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 269799010191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799010192 metal binding site [ion binding]; metal-binding site 269799010193 active site 269799010194 I-site; other site 269799010195 DNA polymerase I; Provisional; Region: PRK05755 269799010196 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 269799010197 active site 269799010198 metal binding site 1 [ion binding]; metal-binding site 269799010199 putative 5' ssDNA interaction site; other site 269799010200 metal binding site 3; metal-binding site 269799010201 metal binding site 2 [ion binding]; metal-binding site 269799010202 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 269799010203 putative DNA binding site [nucleotide binding]; other site 269799010204 putative metal binding site [ion binding]; other site 269799010205 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 269799010206 active site 269799010207 catalytic site [active] 269799010208 substrate binding site [chemical binding]; other site 269799010209 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 269799010210 active site 269799010211 DNA binding site [nucleotide binding] 269799010212 catalytic site [active] 269799010213 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 269799010214 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 269799010215 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 269799010216 putative dimer interface [polypeptide binding]; other site 269799010217 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 269799010218 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 269799010219 Ligand Binding Site [chemical binding]; other site 269799010220 four heptanucleotide repeats; Gmet_H441 269799010221 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 269799010222 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 269799010223 dimer interface [polypeptide binding]; other site 269799010224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799010225 catalytic residue [active] 269799010226 Predicted transcriptional regulator [Transcription]; Region: COG1959 269799010227 Transcriptional regulator; Region: Rrf2; cl17282 269799010228 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 269799010229 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 269799010230 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 269799010231 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 269799010232 nucleotide binding site/active site [active] 269799010233 HIT family signature motif; other site 269799010234 catalytic residue [active] 269799010235 'integration host factor binding site, putative; Gmet_I215A' 269799010236 'integration host factor binding site, putative; Gmet_I215B' 269799010237 endonuclease IV; Provisional; Region: PRK01060 269799010238 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 269799010239 AP (apurinic/apyrimidinic) site pocket; other site 269799010240 DNA interaction; other site 269799010241 Metal-binding active site; metal-binding site 269799010242 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799010243 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799010244 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 269799010245 putative FMN binding site [chemical binding]; other site 269799010246 PAS domain S-box; Region: sensory_box; TIGR00229 269799010247 PAS domain; Region: PAS; smart00091 269799010248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799010249 dimer interface [polypeptide binding]; other site 269799010250 phosphorylation site [posttranslational modification] 269799010251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799010252 ATP binding site [chemical binding]; other site 269799010253 Mg2+ binding site [ion binding]; other site 269799010254 G-X-G motif; other site 269799010255 Response regulator receiver domain; Region: Response_reg; pfam00072 269799010256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010257 active site 269799010258 phosphorylation site [posttranslational modification] 269799010259 intermolecular recognition site; other site 269799010260 dimerization interface [polypeptide binding]; other site 269799010261 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 269799010262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010263 active site 269799010264 phosphorylation site [posttranslational modification] 269799010265 intermolecular recognition site; other site 269799010266 dimerization interface [polypeptide binding]; other site 269799010267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799010268 Zn2+ binding site [ion binding]; other site 269799010269 Mg2+ binding site [ion binding]; other site 269799010270 conserved nucleotide sequence; Gmet_P3000 269799010271 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 269799010272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799010273 non-specific DNA binding site [nucleotide binding]; other site 269799010274 salt bridge; other site 269799010275 sequence-specific DNA binding site [nucleotide binding]; other site 269799010276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799010277 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799010278 conserved nucleotide sequence; Gmet_P3002 269799010279 TIR domain; Region: TIR_2; pfam13676 269799010280 conserved nucleotide sequence; Gmet_P3004 269799010281 integron integrase; Region: integrase_gron; TIGR02249 269799010282 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 269799010283 Int/Topo IB signature motif; other site 269799010284 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 269799010285 putative ADP-ribose binding site [chemical binding]; other site 269799010286 putative active site [active] 269799010287 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 269799010288 putative active site [active] 269799010289 dimerization interface [polypeptide binding]; other site 269799010290 putative tRNAtyr binding site [nucleotide binding]; other site 269799010291 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 269799010292 aminodeoxychorismate synthase; Provisional; Region: PRK07508 269799010293 chorismate binding enzyme; Region: Chorismate_bind; cl10555 269799010294 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 269799010295 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 269799010296 substrate-cofactor binding pocket; other site 269799010297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799010298 homodimer interface [polypeptide binding]; other site 269799010299 catalytic residue [active] 269799010300 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 269799010301 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 269799010302 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269799010303 Peptidase family M23; Region: Peptidase_M23; pfam01551 269799010304 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 269799010305 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 269799010306 G1 box; other site 269799010307 putative GEF interaction site [polypeptide binding]; other site 269799010308 GTP/Mg2+ binding site [chemical binding]; other site 269799010309 Switch I region; other site 269799010310 G2 box; other site 269799010311 G3 box; other site 269799010312 Switch II region; other site 269799010313 G4 box; other site 269799010314 G5 box; other site 269799010315 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 269799010316 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 269799010317 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 269799010318 SnoaL-like domain; Region: SnoaL_3; pfam13474 269799010319 camphor resistance protein CrcB; Provisional; Region: PRK14222 269799010320 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 269799010321 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 269799010322 active site residue [active] 269799010323 Methylamine utilisation protein MauE; Region: MauE; pfam07291 269799010324 membrane protein; Provisional; Region: PRK14393 269799010325 YceG-like family; Region: YceG; pfam02618 269799010326 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 269799010327 dimerization interface [polypeptide binding]; other site 269799010328 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 269799010329 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799010330 catalytic loop [active] 269799010331 iron binding site [ion binding]; other site 269799010332 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 269799010333 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 269799010334 [4Fe-4S] binding site [ion binding]; other site 269799010335 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 269799010336 molybdopterin cofactor binding site; other site 269799010337 conserved nucleotide sequence; Gmet_P3022 269799010338 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 269799010339 glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316 269799010340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269799010341 conserved nucleotide sequence; Gmet_P3023 269799010342 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 269799010343 Protein of unknown function (DUF342); Region: DUF342; pfam03961 269799010344 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 269799010345 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 269799010346 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 269799010347 CoA-binding site [chemical binding]; other site 269799010348 ATP-binding [chemical binding]; other site 269799010349 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 269799010350 Transcriptional regulator [Transcription]; Region: IclR; COG1414 269799010351 Bacterial transcriptional regulator; Region: IclR; pfam01614 269799010352 conserved nucleotide sequence; Gmet_P3027 269799010353 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269799010354 Ligand Binding Site [chemical binding]; other site 269799010355 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 269799010356 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 269799010357 AP (apurinic/apyrimidinic) site pocket; other site 269799010358 DNA interaction; other site 269799010359 Metal-binding active site; metal-binding site 269799010360 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 269799010361 metal binding triad; other site 269799010362 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 269799010363 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 269799010364 Na binding site [ion binding]; other site 269799010365 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 269799010366 Uncharacterized conserved protein [Function unknown]; Region: COG0585 269799010367 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 269799010368 active site 269799010369 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 269799010370 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 269799010371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799010372 S-adenosylmethionine binding site [chemical binding]; other site 269799010373 major capsid protein; Region: PHA00201 269799010374 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 269799010375 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 269799010376 ATP binding site [chemical binding]; other site 269799010377 Mg++ binding site [ion binding]; other site 269799010378 motif III; other site 269799010379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799010380 nucleotide binding region [chemical binding]; other site 269799010381 ATP-binding site [chemical binding]; other site 269799010382 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269799010383 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 269799010384 FtsX-like permease family; Region: FtsX; pfam02687 269799010385 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269799010386 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269799010387 Walker A/P-loop; other site 269799010388 ATP binding site [chemical binding]; other site 269799010389 Q-loop/lid; other site 269799010390 ABC transporter signature motif; other site 269799010391 Walker B; other site 269799010392 D-loop; other site 269799010393 H-loop/switch region; other site 269799010394 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269799010395 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269799010396 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799010397 conserved nucleotide sequence; Gmet_R0136 269799010398 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799010399 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799010400 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799010401 Uncharacterized conserved protein [Function unknown]; Region: COG2006 269799010402 Domain of unknown function (DUF362); Region: DUF362; pfam04015 269799010403 4Fe-4S binding domain; Region: Fer4; pfam00037 269799010404 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799010405 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 269799010406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799010407 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269799010408 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 269799010409 active site 269799010410 DNA binding site [nucleotide binding] 269799010411 Int/Topo IB signature motif; other site 269799010412 conserved nucleotide sequence; Gmet_P3043 269799010413 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 269799010414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 269799010415 ATP binding site [chemical binding]; other site 269799010416 putative Mg++ binding site [ion binding]; other site 269799010417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799010418 nucleotide binding region [chemical binding]; other site 269799010419 ATP-binding site [chemical binding]; other site 269799010420 conserved palindrome; Gmet_R0137 269799010421 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269799010422 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 269799010423 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269799010424 conserved nucleotide sequence; Gmet_P3044 269799010425 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 269799010426 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 269799010427 Integrase core domain; Region: rve; pfam00665 269799010428 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 269799010429 Bacterial TniB protein; Region: TniB; pfam05621 269799010430 AAA domain; Region: AAA_22; pfam13401 269799010431 TniQ; Region: TniQ; pfam06527 269799010432 'ISGsu7, transposase OrfA N-terminal fragment and 5' sequence; Gmet_R0138' 269799010433 Part of AAA domain; Region: AAA_19; pfam13245 269799010434 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 269799010435 AAA domain; Region: AAA_12; pfam13087 269799010436 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 269799010437 putative active site [active] 269799010438 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 269799010439 T5orf172 domain; Region: T5orf172; pfam10544 269799010440 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269799010441 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 269799010442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010443 binding surface 269799010444 TPR motif; other site 269799010445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010446 TPR motif; other site 269799010447 binding surface 269799010448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010449 binding surface 269799010450 TPR motif; other site 269799010451 Staphylococcal nuclease homologues; Region: SNc; smart00318 269799010452 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 269799010453 Catalytic site; other site 269799010454 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 269799010455 active site 269799010456 catalytic site [active] 269799010457 substrate binding site [chemical binding]; other site 269799010458 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269799010459 IHF dimer interface [polypeptide binding]; other site 269799010460 IHF - DNA interface [nucleotide binding]; other site 269799010461 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269799010462 IHF dimer interface [polypeptide binding]; other site 269799010463 IHF - DNA interface [nucleotide binding]; other site 269799010464 DEAD-like helicases superfamily; Region: DEXDc; smart00487 269799010465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799010466 ATP-binding site [chemical binding]; other site 269799010467 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 269799010468 PLD-like domain; Region: PLDc_2; pfam13091 269799010469 putative homodimer interface [polypeptide binding]; other site 269799010470 putative active site [active] 269799010471 catalytic site [active] 269799010472 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 269799010473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 269799010474 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 269799010475 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 269799010476 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 269799010477 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 269799010478 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 269799010479 thioredoxin reductase; Provisional; Region: PRK10262 269799010480 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 269799010481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799010482 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 269799010483 threonine dehydratase; Provisional; Region: PRK08198 269799010484 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 269799010485 tetramer interface [polypeptide binding]; other site 269799010486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799010487 catalytic residue [active] 269799010488 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 269799010489 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 269799010490 putative GTP cyclohydrolase; Provisional; Region: PRK13674 269799010491 'integration host factor binding site, putative; Gmet_I305A' 269799010492 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 269799010493 Ligand Binding Site [chemical binding]; other site 269799010494 'integration host factor binding site, putative; Gmet_I305B' 269799010495 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 269799010496 putative active site [active] 269799010497 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 269799010498 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 269799010499 putative active site [active] 269799010500 catalytic site [active] 269799010501 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 269799010502 putative active site [active] 269799010503 catalytic site [active] 269799010504 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 269799010505 conserved nucleotide sequence; Gmet_I413 269799010506 conserved nucleotide sequence; Gmet_I414 269799010507 Homeodomain-like domain; Region: HTH_23; pfam13384 269799010508 Winged helix-turn helix; Region: HTH_29; pfam13551 269799010509 Integrase core domain; Region: rve; pfam00665 269799010510 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 269799010511 Aspartase; Region: Aspartase; cd01357 269799010512 active sites [active] 269799010513 tetramer interface [polypeptide binding]; other site 269799010514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269799010515 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 269799010516 active site 269799010517 motif I; other site 269799010518 motif II; other site 269799010519 Uncharacterized conserved protein [Function unknown]; Region: COG1633 269799010520 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269799010521 diiron binding motif [ion binding]; other site 269799010522 Uncharacterized conserved protein [Function unknown]; Region: COG1565 269799010523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799010524 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 269799010525 putative active site [active] 269799010526 heme pocket [chemical binding]; other site 269799010527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799010528 putative active site [active] 269799010529 heme pocket [chemical binding]; other site 269799010530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799010531 putative active site [active] 269799010532 heme pocket [chemical binding]; other site 269799010533 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269799010534 metal binding site [ion binding]; metal-binding site 269799010535 active site 269799010536 I-site; other site 269799010537 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 269799010538 Predicted transcriptional regulator [Transcription]; Region: COG2378 269799010539 HTH domain; Region: HTH_11; pfam08279 269799010540 WYL domain; Region: WYL; pfam13280 269799010541 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 269799010542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799010543 dimerization interface [polypeptide binding]; other site 269799010544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799010545 dimer interface [polypeptide binding]; other site 269799010546 putative CheW interface [polypeptide binding]; other site 269799010547 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 269799010548 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 269799010549 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 269799010550 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 269799010551 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 269799010552 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 269799010553 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 269799010554 toxin interface [polypeptide binding]; other site 269799010555 Zn binding site [ion binding]; other site 269799010556 conserved nucleotide sequence; Gmet_R1021 269799010557 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 269799010558 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 269799010559 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 269799010560 four heptanucleotide repeats; Gmet_H442 269799010561 flagellar biosynthetic protein FliQ; Region: fliQ; TIGR01402 269799010562 four heptanucleotide repeats; Gmet_H443 269799010563 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 269799010564 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 269799010565 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 269799010566 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 269799010567 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 269799010568 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 269799010569 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799010570 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799010571 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 269799010572 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 269799010573 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 269799010574 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269799010575 conserved nucleotide sequence; Gmet_R0139 269799010576 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 269799010577 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 269799010578 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 269799010579 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 269799010580 conserved nucleotide sequence; Gmet_R1022 269799010581 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 269799010582 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 269799010583 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 269799010584 Walker A motif/ATP binding site; other site 269799010585 Walker B motif; other site 269799010586 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 269799010587 Flagellar assembly protein FliH; Region: FliH; pfam02108 269799010588 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 269799010589 MgtE intracellular N domain; Region: MgtE_N; cl15244 269799010590 FliG C-terminal domain; Region: FliG_C; pfam01706 269799010591 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 269799010592 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 269799010593 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 269799010594 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 269799010595 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 269799010596 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 269799010597 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 269799010598 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 269799010599 'integration host factor binding site, putative; Gmet_I306A' 269799010600 'integration host factor binding site, putative; Gmet_I306B' 269799010601 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 269799010602 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 269799010603 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799010604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010605 active site 269799010606 phosphorylation site [posttranslational modification] 269799010607 dimerization interface [polypeptide binding]; other site 269799010608 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 269799010609 Response regulator receiver domain; Region: Response_reg; pfam00072 269799010610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010611 active site 269799010612 phosphorylation site [posttranslational modification] 269799010613 intermolecular recognition site; other site 269799010614 dimerization interface [polypeptide binding]; other site 269799010615 Hemerythrin; Region: Hemerythrin; cd12107 269799010616 Fe binding site [ion binding]; other site 269799010617 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 269799010618 active site residue [active] 269799010619 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 269799010620 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 269799010621 Domain of unknown function DUF302; Region: DUF302; cl01364 269799010622 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 269799010623 conserved palindrome; Gmet_R5008 269799010624 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 269799010625 Protein export membrane protein; Region: SecD_SecF; cl14618 269799010626 Protein export membrane protein; Region: SecD_SecF; cl14618 269799010627 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 269799010628 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799010629 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 269799010630 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 269799010631 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 269799010632 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 269799010633 Bacitracin resistance protein BacA; Region: BacA; pfam02673 269799010634 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 269799010635 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 269799010636 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 269799010637 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 269799010638 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799010639 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799010640 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799010641 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 269799010642 multiple promoter invertase; Provisional; Region: mpi; PRK13413 269799010643 catalytic residues [active] 269799010644 catalytic nucleophile [active] 269799010645 Presynaptic Site I dimer interface [polypeptide binding]; other site 269799010646 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 269799010647 Synaptic Flat tetramer interface [polypeptide binding]; other site 269799010648 Synaptic Site I dimer interface [polypeptide binding]; other site 269799010649 DNA binding site [nucleotide binding] 269799010650 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 269799010651 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 269799010652 catalytic residues [active] 269799010653 catalytic nucleophile [active] 269799010654 Recombinase; Region: Recombinase; pfam07508 269799010655 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 269799010656 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 269799010657 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 269799010658 putative NAD(P) binding site [chemical binding]; other site 269799010659 active site 269799010660 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269799010661 diiron binding motif [ion binding]; other site 269799010662 conserved nucleotide sequence; Gmet_R1023 269799010663 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 269799010664 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269799010665 Dodecin; Region: Dodecin; pfam07311 269799010666 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 269799010667 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 269799010668 lipoyl synthase; Provisional; Region: PRK05481 269799010669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799010670 FeS/SAM binding site; other site 269799010671 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 269799010672 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 269799010673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799010674 catalytic residue [active] 269799010675 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 269799010676 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 269799010677 tetramer interface [polypeptide binding]; other site 269799010678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799010679 catalytic residue [active] 269799010680 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 269799010681 lipoyl attachment site [posttranslational modification]; other site 269799010682 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 269799010683 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 269799010684 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 269799010685 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 269799010686 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 269799010687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799010688 dimerization interface [polypeptide binding]; other site 269799010689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799010690 dimer interface [polypeptide binding]; other site 269799010691 phosphorylation site [posttranslational modification] 269799010692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799010693 ATP binding site [chemical binding]; other site 269799010694 Mg2+ binding site [ion binding]; other site 269799010695 G-X-G motif; other site 269799010696 four heptanucleotide repeats; Gmet_H444 269799010697 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799010698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010699 active site 269799010700 phosphorylation site [posttranslational modification] 269799010701 intermolecular recognition site; other site 269799010702 dimerization interface [polypeptide binding]; other site 269799010703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799010704 Walker A motif; other site 269799010705 ATP binding site [chemical binding]; other site 269799010706 Walker B motif; other site 269799010707 arginine finger; other site 269799010708 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799010709 four heptanucleotide repeats; Gmet_H445 269799010710 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 269799010711 putative homodimer interface [polypeptide binding]; other site 269799010712 putative active site pocket [active] 269799010713 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 269799010714 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 269799010715 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 269799010716 Surface antigen; Region: Bac_surface_Ag; pfam01103 269799010717 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 269799010718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269799010719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799010720 non-specific DNA binding site [nucleotide binding]; other site 269799010721 salt bridge; other site 269799010722 sequence-specific DNA binding site [nucleotide binding]; other site 269799010723 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799010724 heme-binding residues [chemical binding]; other site 269799010725 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 269799010726 heme-binding residues [chemical binding]; other site 269799010727 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 269799010728 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 269799010729 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 269799010730 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 269799010731 conserved nucleotide sequence; Gmet_P3168 269799010732 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 269799010733 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 269799010734 active site 269799010735 substrate-binding site [chemical binding]; other site 269799010736 metal-binding site [ion binding] 269799010737 ATP binding site [chemical binding]; other site 269799010738 4Fe-4S binding domain; Region: Fer4; cl02805 269799010739 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 269799010740 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 269799010741 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 269799010742 Rubredoxin; Region: Rubredoxin; pfam00301 269799010743 iron binding site [ion binding]; other site 269799010744 Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326 269799010745 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 269799010746 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269799010747 catalytic residue [active] 269799010748 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 269799010749 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 269799010750 glycogen synthase; Provisional; Region: glgA; PRK00654 269799010751 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 269799010752 ADP-binding pocket [chemical binding]; other site 269799010753 homodimer interface [polypeptide binding]; other site 269799010754 ADP-glucose phosphorylase; Region: PLN02643 269799010755 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 269799010756 dimer interface [polypeptide binding]; other site 269799010757 active site 269799010758 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 269799010759 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 269799010760 putative active site [active] 269799010761 catalytic site [active] 269799010762 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 269799010763 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 269799010764 active site 269799010765 Substrate binding site; other site 269799010766 Mg++ binding site; other site 269799010767 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 269799010768 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 269799010769 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 269799010770 Response regulator receiver domain; Region: Response_reg; pfam00072 269799010771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010772 active site 269799010773 phosphorylation site [posttranslational modification] 269799010774 intermolecular recognition site; other site 269799010775 dimerization interface [polypeptide binding]; other site 269799010776 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799010777 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799010778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799010779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799010780 dimer interface [polypeptide binding]; other site 269799010781 phosphorylation site [posttranslational modification] 269799010782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799010783 ATP binding site [chemical binding]; other site 269799010784 G-X-G motif; other site 269799010785 conserved nucleotide sequence; Gmet_P3181 269799010786 poly(A) polymerase; Region: pcnB; TIGR01942 269799010787 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 269799010788 active site 269799010789 NTP binding site [chemical binding]; other site 269799010790 metal binding triad [ion binding]; metal-binding site 269799010791 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 269799010792 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 269799010793 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799010794 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799010795 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799010796 hypothetical protein; Provisional; Region: PRK10410 269799010797 4Fe-4S binding domain; Region: Fer4_6; pfam12837 269799010798 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799010799 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 269799010800 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 269799010801 dimer interface [polypeptide binding]; other site 269799010802 decamer (pentamer of dimers) interface [polypeptide binding]; other site 269799010803 catalytic triad [active] 269799010804 peroxidatic and resolving cysteines [active] 269799010805 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 269799010806 DNA polymerase type-B family; Region: POLBc; smart00486 269799010807 active site 269799010808 catalytic site [active] 269799010809 substrate binding site [chemical binding]; other site 269799010810 DNA polymerase family B; Region: DNA_pol_B; pfam00136 269799010811 DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538 269799010812 active site 269799010813 metal-binding site 269799010814 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 269799010815 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 269799010816 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 269799010817 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 269799010818 B12 binding site [chemical binding]; other site 269799010819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799010820 FeS/SAM binding site; other site 269799010821 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 269799010822 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 269799010823 ribonuclease G; Provisional; Region: PRK11712 269799010824 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 269799010825 homodimer interface [polypeptide binding]; other site 269799010826 oligonucleotide binding site [chemical binding]; other site 269799010827 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 269799010828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269799010829 ATP-grasp domain; Region: ATP-grasp; pfam02222 269799010830 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 269799010831 iron-sulfur cluster [ion binding]; other site 269799010832 [2Fe-2S] cluster binding site [ion binding]; other site 269799010833 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 269799010834 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 269799010835 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 269799010836 GTPase CgtA; Reviewed; Region: obgE; PRK12299 269799010837 GTP1/OBG; Region: GTP1_OBG; pfam01018 269799010838 Obg GTPase; Region: Obg; cd01898 269799010839 G1 box; other site 269799010840 GTP/Mg2+ binding site [chemical binding]; other site 269799010841 Switch I region; other site 269799010842 G2 box; other site 269799010843 G3 box; other site 269799010844 Switch II region; other site 269799010845 G4 box; other site 269799010846 G5 box; other site 269799010847 gamma-glutamyl kinase; Provisional; Region: PRK05429 269799010848 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 269799010849 nucleotide binding site [chemical binding]; other site 269799010850 homotetrameric interface [polypeptide binding]; other site 269799010851 putative phosphate binding site [ion binding]; other site 269799010852 putative allosteric binding site; other site 269799010853 PUA domain; Region: PUA; pfam01472 269799010854 'integration host factor binding site, putative; Gmet_I307A' 269799010855 'integration host factor binding site, putative; Gmet_I307B' 269799010856 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 269799010857 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 269799010858 putative catalytic cysteine [active] 269799010859 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 269799010860 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 269799010861 active site 269799010862 (T/H)XGH motif; other site 269799010863 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 269799010864 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 269799010865 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 269799010866 phosphoglyceromutase; Provisional; Region: PRK05434 269799010867 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 269799010868 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 269799010869 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 269799010870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799010871 FeS/SAM binding site; other site 269799010872 TRAM domain; Region: TRAM; cl01282 269799010873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 269799010874 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 269799010875 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 269799010876 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 269799010877 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 269799010878 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 269799010879 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 269799010880 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 269799010881 CheC-like family; Region: CheC; pfam04509 269799010882 CheC-like family; Region: CheC; pfam04509 269799010883 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 269799010884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010885 active site 269799010886 phosphorylation site [posttranslational modification] 269799010887 intermolecular recognition site; other site 269799010888 dimerization interface [polypeptide binding]; other site 269799010889 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 269799010890 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269799010891 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269799010892 thiamine monophosphate kinase; Provisional; Region: PRK05731 269799010893 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 269799010894 ATP binding site [chemical binding]; other site 269799010895 dimerization interface [polypeptide binding]; other site 269799010896 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 269799010897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799010898 Walker A motif; other site 269799010899 ATP binding site [chemical binding]; other site 269799010900 Walker B motif; other site 269799010901 arginine finger; other site 269799010902 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 269799010903 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 269799010904 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 269799010905 putative dimer interface [polypeptide binding]; other site 269799010906 TPR repeat; Region: TPR_11; pfam13414 269799010907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010908 TPR motif; other site 269799010909 binding surface 269799010910 TPR repeat; Region: TPR_11; pfam13414 269799010911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010912 binding surface 269799010913 TPR motif; other site 269799010914 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799010915 TPR repeat; Region: TPR_11; pfam13414 269799010916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010917 binding surface 269799010918 TPR motif; other site 269799010919 TPR repeat; Region: TPR_11; pfam13414 269799010920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010921 TPR motif; other site 269799010922 binding surface 269799010923 TPR repeat; Region: TPR_11; pfam13414 269799010924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799010925 binding surface 269799010926 TPR motif; other site 269799010927 TPR repeat; Region: TPR_11; pfam13414 269799010928 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 269799010929 Response regulator receiver domain; Region: Response_reg; pfam00072 269799010930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010931 active site 269799010932 phosphorylation site [posttranslational modification] 269799010933 intermolecular recognition site; other site 269799010934 dimerization interface [polypeptide binding]; other site 269799010935 excinuclease ABC subunit B; Provisional; Region: PRK05298 269799010936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269799010937 ATP binding site [chemical binding]; other site 269799010938 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799010939 nucleotide binding region [chemical binding]; other site 269799010940 ATP-binding site [chemical binding]; other site 269799010941 Ultra-violet resistance protein B; Region: UvrB; pfam12344 269799010942 UvrB/uvrC motif; Region: UVR; pfam02151 269799010943 Response regulator receiver domain; Region: Response_reg; pfam00072 269799010944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799010945 active site 269799010946 phosphorylation site [posttranslational modification] 269799010947 intermolecular recognition site; other site 269799010948 dimerization interface [polypeptide binding]; other site 269799010949 PilZ domain; Region: PilZ; pfam07238 269799010950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269799010951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269799010952 putative substrate translocation pore; other site 269799010953 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 269799010954 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 269799010955 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 269799010956 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 269799010957 Part of AAA domain; Region: AAA_19; pfam13245 269799010958 Family description; Region: UvrD_C_2; pfam13538 269799010959 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 269799010960 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799010961 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 269799010962 Tetratricopeptide repeat; Region: TPR_6; pfam13174 269799010963 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 269799010964 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 269799010965 conserved nucleotide sequence; Gmet_P3227 269799010966 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 269799010967 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 269799010968 GIY-YIG motif/motif A; other site 269799010969 active site 269799010970 catalytic site [active] 269799010971 putative DNA binding site [nucleotide binding]; other site 269799010972 metal binding site [ion binding]; metal-binding site 269799010973 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 269799010974 H3TH domains of Flap endonuclease-1 (FEN1)-like structure specific 5' nucleases; Region: H3TH_FEN1-XPG-like; cd09897 269799010975 putative DNA binding site [nucleotide binding]; other site 269799010976 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 269799010977 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269799010978 catalytic residues [active] 269799010979 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 269799010980 catalytic residues [active] 269799010981 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 269799010982 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 269799010983 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 269799010984 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 269799010985 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 269799010986 tRNA; other site 269799010987 putative tRNA binding site [nucleotide binding]; other site 269799010988 putative NADP binding site [chemical binding]; other site 269799010989 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 269799010990 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 269799010991 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 269799010992 domain interfaces; other site 269799010993 active site 269799010994 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 269799010995 active site 269799010996 SAM binding site [chemical binding]; other site 269799010997 homodimer interface [polypeptide binding]; other site 269799010998 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 269799010999 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 269799011000 active site 269799011001 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 269799011002 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 269799011003 active site 269799011004 'integration host factor binding site, putative; Gmet_I216A' 269799011005 'integration host factor binding site, putative; Gmet_I216B' 269799011006 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 269799011007 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 269799011008 putative ATP binding site [chemical binding]; other site 269799011009 putative substrate interface [chemical binding]; other site 269799011010 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269799011011 diiron binding motif [ion binding]; other site 269799011012 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 269799011013 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 269799011014 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 269799011015 metal binding site 2 [ion binding]; metal-binding site 269799011016 putative DNA binding helix; other site 269799011017 metal binding site 1 [ion binding]; metal-binding site 269799011018 dimer interface [polypeptide binding]; other site 269799011019 structural Zn2+ binding site [ion binding]; other site 269799011020 Rubredoxin [Energy production and conversion]; Region: COG1773 269799011021 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 269799011022 iron binding site [ion binding]; other site 269799011023 Uncharacterized conserved protein [Function unknown]; Region: COG1633 269799011024 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 269799011025 diiron binding motif [ion binding]; other site 269799011026 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 269799011027 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269799011028 Flavodoxin; Region: Flavodoxin_1; pfam00258 269799011029 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 269799011030 'integration host factor binding site, putative; Gmet_I122A' 269799011031 'integration host factor binding site, putative; Gmet_I122B' 269799011032 FAD binding domain; Region: FAD_binding_4; pfam01565 269799011033 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 269799011034 'integration host factor binding site, putative; Gmet_I217A' 269799011035 'integration host factor binding site, putative; Gmet_I217B' 269799011036 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 269799011037 Cysteine-rich domain; Region: CCG; pfam02754 269799011038 Cysteine-rich domain; Region: CCG; pfam02754 269799011039 conserved nucleotide sequence; Gmet_P3247 269799011040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799011041 sequence-specific DNA binding site [nucleotide binding]; other site 269799011042 salt bridge; other site 269799011043 Cupin domain; Region: Cupin_2; pfam07883 269799011044 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 269799011045 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 269799011046 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 269799011047 'integration host factor binding site, putative; Gmet_I218A' 269799011048 'integration host factor binding site, putative; Gmet_I218B' 269799011049 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269799011050 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269799011051 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269799011052 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 269799011053 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269799011054 carboxyltransferase (CT) interaction site; other site 269799011055 biotinylation site [posttranslational modification]; other site 269799011056 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 269799011057 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 269799011058 TMP-binding site; other site 269799011059 ATP-binding site [chemical binding]; other site 269799011060 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 269799011061 GxxExxY protein; Region: GxxExxY; TIGR04256 269799011062 'integration host factor binding site, putative; Gmet_I219A' 269799011063 'integration host factor binding site, putative; Gmet_I219B' 269799011064 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 269799011065 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 269799011066 dimer interface [polypeptide binding]; other site 269799011067 substrate binding site [chemical binding]; other site 269799011068 metal binding site [ion binding]; metal-binding site 269799011069 conserved nucleotide sequence; Gmet_P3254 269799011070 conserved nucleotide sequence; Gmet_R0140 269799011071 conserved nucleotide sequence; Gmet_R0141 269799011072 Family description; Region: VCBS; pfam13517 269799011073 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 269799011074 mannose binding site [chemical binding]; other site 269799011075 dimerization interface [polypeptide binding]; other site 269799011076 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 269799011077 active site 269799011078 NTP binding site [chemical binding]; other site 269799011079 metal binding triad [ion binding]; metal-binding site 269799011080 antibiotic binding site [chemical binding]; other site 269799011081 Uncharacterized conserved protein [Function unknown]; Region: COG2445 269799011082 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 269799011083 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 269799011084 dimer interface [polypeptide binding]; other site 269799011085 motif 1; other site 269799011086 active site 269799011087 motif 2; other site 269799011088 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 269799011089 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 269799011090 GDP-binding site [chemical binding]; other site 269799011091 ACT binding site; other site 269799011092 IMP binding site; other site 269799011093 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 269799011094 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 269799011095 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 269799011096 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 269799011097 N-acetyl-D-glucosamine binding site [chemical binding]; other site 269799011098 catalytic residue [active] 269799011099 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269799011100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799011101 active site 269799011102 phosphorylation site [posttranslational modification] 269799011103 intermolecular recognition site; other site 269799011104 dimerization interface [polypeptide binding]; other site 269799011105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799011106 Walker A motif; other site 269799011107 ATP binding site [chemical binding]; other site 269799011108 Walker B motif; other site 269799011109 arginine finger; other site 269799011110 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 269799011111 conserved nucleotide sequence; Gmet_P3263 269799011112 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 269799011113 putative CheA interaction surface; other site 269799011114 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 269799011115 putative binding surface; other site 269799011116 active site 269799011117 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 269799011118 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 269799011119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799011120 ATP binding site [chemical binding]; other site 269799011121 Mg2+ binding site [ion binding]; other site 269799011122 G-X-G motif; other site 269799011123 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 269799011124 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 269799011125 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 269799011126 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 269799011127 HDOD domain; Region: HDOD; pfam08668 269799011128 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799011129 Zn2+ binding site [ion binding]; other site 269799011130 Mg2+ binding site [ion binding]; other site 269799011131 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 269799011132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799011133 active site 269799011134 phosphorylation site [posttranslational modification] 269799011135 intermolecular recognition site; other site 269799011136 dimerization interface [polypeptide binding]; other site 269799011137 CheB methylesterase; Region: CheB_methylest; pfam01339 269799011138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799011139 S-adenosylmethionine binding site [chemical binding]; other site 269799011140 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 269799011141 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 269799011142 dimer interface [polypeptide binding]; other site 269799011143 active site 269799011144 CoA binding pocket [chemical binding]; other site 269799011145 'integration host factor binding site, putative (internal deletion); Gmet_I220A' 269799011146 HEAT repeats; Region: HEAT_2; pfam13646 269799011147 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 269799011148 protein binding surface [polypeptide binding]; other site 269799011149 HEAT repeats; Region: HEAT_2; pfam13646 269799011150 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 269799011151 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799011152 Zn2+ binding site [ion binding]; other site 269799011153 Mg2+ binding site [ion binding]; other site 269799011154 HEAT repeats; Region: HEAT_2; pfam13646 269799011155 HEAT repeats; Region: HEAT_2; pfam13646 269799011156 DNA repair protein RadA; Provisional; Region: PRK11823 269799011157 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 269799011158 Walker A motif/ATP binding site; other site 269799011159 ATP binding site [chemical binding]; other site 269799011160 Walker B motif; other site 269799011161 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 269799011162 GAF domain; Region: GAF; cl17456 269799011163 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 269799011164 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 269799011165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799011166 dimer interface [polypeptide binding]; other site 269799011167 phosphorylation site [posttranslational modification] 269799011168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799011169 ATP binding site [chemical binding]; other site 269799011170 Mg2+ binding site [ion binding]; other site 269799011171 G-X-G motif; other site 269799011172 transposase/IS protein; Provisional; Region: PRK09183 269799011173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799011174 Walker A motif; other site 269799011175 ATP binding site [chemical binding]; other site 269799011176 Walker B motif; other site 269799011177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 269799011178 Integrase core domain; Region: rve; pfam00665 269799011179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799011180 enoyl-CoA hydratase; Provisional; Region: PRK09245 269799011181 substrate binding site [chemical binding]; other site 269799011182 oxyanion hole (OAH) forming residues; other site 269799011183 trimer interface [polypeptide binding]; other site 269799011184 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 269799011185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799011186 putative active site [active] 269799011187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799011188 Walker A motif; other site 269799011189 ATP binding site [chemical binding]; other site 269799011190 Walker B motif; other site 269799011191 arginine finger; other site 269799011192 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799011193 Transcriptional regulator [Transcription]; Region: IclR; COG1414 269799011194 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 269799011195 Bacterial transcriptional regulator; Region: IclR; pfam01614 269799011196 Protein of unknown function, DUF485; Region: DUF485; pfam04341 269799011197 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 269799011198 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 269799011199 Na binding site [ion binding]; other site 269799011200 isovaleryl-CoA dehydrogenase; Region: PLN02519 269799011201 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 269799011202 substrate binding site [chemical binding]; other site 269799011203 FAD binding site [chemical binding]; other site 269799011204 catalytic base [active] 269799011205 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 269799011206 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 269799011207 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 269799011208 conserved nucleotide sequence; Gmet_R1024 269799011209 enoyl-CoA hydratase; Provisional; Region: PRK05995 269799011210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799011211 substrate binding site [chemical binding]; other site 269799011212 oxyanion hole (OAH) forming residues; other site 269799011213 trimer interface [polypeptide binding]; other site 269799011214 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 269799011215 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269799011216 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 269799011217 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269799011218 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269799011219 carboxyltransferase (CT) interaction site; other site 269799011220 biotinylation site [posttranslational modification]; other site 269799011221 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 269799011222 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 269799011223 active site 269799011224 catalytic residues [active] 269799011225 metal binding site [ion binding]; metal-binding site 269799011226 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 269799011227 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269799011228 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269799011229 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 269799011230 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 269799011231 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 269799011232 Ligand binding site [chemical binding]; other site 269799011233 Electron transfer flavoprotein domain; Region: ETF; pfam01012 269799011234 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 269799011235 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 269799011236 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 269799011237 putative acyltransferase; Provisional; Region: PRK05790 269799011238 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 269799011239 dimer interface [polypeptide binding]; other site 269799011240 active site 269799011241 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 269799011242 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 269799011243 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 269799011244 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase; Region: dearomat_oah; TIGR03200 269799011245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 269799011246 substrate binding site [chemical binding]; other site 269799011247 oxyanion hole (OAH) forming residues; other site 269799011248 trimer interface [polypeptide binding]; other site 269799011249 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799011250 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269799011251 active site 269799011252 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 269799011253 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 269799011254 active site 269799011255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799011256 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 269799011257 Walker A motif; other site 269799011258 ATP binding site [chemical binding]; other site 269799011259 Walker B motif; other site 269799011260 arginine finger; other site 269799011261 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269799011262 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 269799011263 nudix motif; other site 269799011264 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 269799011265 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 269799011266 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 269799011267 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 269799011268 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 269799011269 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 269799011270 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 269799011271 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 269799011272 Clp amino terminal domain; Region: Clp_N; pfam02861 269799011273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799011274 Walker A motif; other site 269799011275 ATP binding site [chemical binding]; other site 269799011276 Walker B motif; other site 269799011277 arginine finger; other site 269799011278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799011279 Walker A motif; other site 269799011280 ATP binding site [chemical binding]; other site 269799011281 Walker B motif; other site 269799011282 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 269799011283 Bacterial SH3 domain; Region: SH3_3; pfam08239 269799011284 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 269799011285 putative CheA interaction surface; other site 269799011286 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 269799011287 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 269799011288 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 269799011289 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 269799011290 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 269799011291 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799011292 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799011293 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 269799011294 nickel binding site [ion binding]; other site 269799011295 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 269799011296 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 269799011297 dimer interface [polypeptide binding]; other site 269799011298 putative CheW interface [polypeptide binding]; other site 269799011299 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 269799011300 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269799011301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799011302 homodimer interface [polypeptide binding]; other site 269799011303 catalytic residue [active] 269799011304 conserved nucleotide sequence; Gmet_R0142 269799011305 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 269799011306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 269799011307 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 269799011308 active site 269799011309 'integration host factor binding site, putative; Gmet_I123A' 269799011310 'integration host factor binding site, putative; Gmet_I123B' 269799011311 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 269799011312 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 269799011313 putative substrate-binding site; other site 269799011314 nickel binding site [ion binding]; other site 269799011315 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 269799011316 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 269799011317 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 269799011318 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 269799011319 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 269799011320 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 269799011321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269799011322 active site 269799011323 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 269799011324 4Fe-4S binding domain; Region: Fer4_5; pfam12801 269799011325 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799011326 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 269799011327 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799011328 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 269799011329 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 269799011330 Ligand Binding Site [chemical binding]; other site 269799011331 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 269799011332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269799011333 ATP binding site [chemical binding]; other site 269799011334 putative Mg++ binding site [ion binding]; other site 269799011335 helicase superfamily c-terminal domain; Region: HELICc; smart00490 269799011336 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 269799011337 active site 269799011338 catalytic residues [active] 269799011339 metal binding site [ion binding]; metal-binding site 269799011340 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 269799011341 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 269799011342 putative active site [active] 269799011343 substrate binding site [chemical binding]; other site 269799011344 putative cosubstrate binding site; other site 269799011345 catalytic site [active] 269799011346 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 269799011347 substrate binding site [chemical binding]; other site 269799011348 Protein of unknown function DUF116; Region: DUF116; pfam01976 269799011349 Transposase, Mutator family; Region: Transposase_mut; pfam00872 269799011350 MULE transposase domain; Region: MULE; pfam10551 269799011351 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 269799011352 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799011353 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 269799011354 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799011355 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 269799011356 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 269799011357 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269799011358 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 269799011359 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 269799011360 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 269799011361 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 269799011362 4Fe-4S binding domain; Region: Fer4; pfam00037 269799011363 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 269799011364 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 269799011365 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799011366 catalytic loop [active] 269799011367 iron binding site [ion binding]; other site 269799011368 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 269799011369 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 269799011370 molybdopterin cofactor binding site; other site 269799011371 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 269799011372 molybdopterin cofactor binding site; other site 269799011373 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 269799011374 dimer interface [polypeptide binding]; other site 269799011375 [2Fe-2S] cluster binding site [ion binding]; other site 269799011376 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 269799011377 SLBB domain; Region: SLBB; pfam10531 269799011378 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 269799011379 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 269799011380 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 269799011381 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 269799011382 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 269799011383 putative dimer interface [polypeptide binding]; other site 269799011384 [2Fe-2S] cluster binding site [ion binding]; other site 269799011385 NADH dehydrogenase subunit D; Validated; Region: PRK06075 269799011386 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 269799011387 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 269799011388 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 269799011389 NADH dehydrogenase subunit B; Validated; Region: PRK06411 269799011390 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 269799011391 conserved nucleotide sequence; Gmet_R0143 269799011392 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 269799011393 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269799011394 inhibitor-cofactor binding pocket; inhibition site 269799011395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799011396 catalytic residue [active] 269799011397 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 269799011398 ATP synthase I chain; Region: ATP_synt_I; cl09170 269799011399 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 269799011400 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 269799011401 ATP synthase subunit C; Region: ATP-synt_C; cl00466 269799011402 multifunctional aminopeptidase A; Provisional; Region: PRK00913 269799011403 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 269799011404 interface (dimer of trimers) [polypeptide binding]; other site 269799011405 Substrate-binding/catalytic site; other site 269799011406 Zn-binding sites [ion binding]; other site 269799011407 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 269799011408 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269799011409 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269799011410 protein binding site [polypeptide binding]; other site 269799011411 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269799011412 protein binding site [polypeptide binding]; other site 269799011413 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 269799011414 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269799011415 protein binding site [polypeptide binding]; other site 269799011416 type II secretion system protein D; Region: type_II_gspD; TIGR02517 269799011417 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 269799011418 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 269799011419 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 269799011420 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 269799011421 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269799011422 type II secretion system protein E; Region: type_II_gspE; TIGR02533 269799011423 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 269799011424 Walker A motif; other site 269799011425 ATP binding site [chemical binding]; other site 269799011426 Walker B motif; other site 269799011427 type II secretion system protein F; Region: GspF; TIGR02120 269799011428 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 269799011429 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 269799011430 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 269799011431 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 269799011432 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 269799011433 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 269799011434 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 269799011435 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 269799011436 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 269799011437 GspL periplasmic domain; Region: GspL_C; cl14909 269799011438 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 269799011439 Domain of unknown function (DUF309); Region: DUF309; pfam03745 269799011440 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 269799011441 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 269799011442 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 269799011443 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 269799011444 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 269799011445 futalosine nucleosidase; Region: fut_nucase; TIGR03664 269799011446 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 269799011447 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799011448 dimerization interface [polypeptide binding]; other site 269799011449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799011450 dimer interface [polypeptide binding]; other site 269799011451 phosphorylation site [posttranslational modification] 269799011452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799011453 ATP binding site [chemical binding]; other site 269799011454 Mg2+ binding site [ion binding]; other site 269799011455 G-X-G motif; other site 269799011456 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269799011457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799011458 active site 269799011459 phosphorylation site [posttranslational modification] 269799011460 intermolecular recognition site; other site 269799011461 dimerization interface [polypeptide binding]; other site 269799011462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269799011463 DNA binding site [nucleotide binding] 269799011464 PEP synthetase regulatory protein; Provisional; Region: PRK05339 269799011465 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 269799011466 amidohydrolase; Region: amidohydrolases; TIGR01891 269799011467 metal binding site [ion binding]; metal-binding site 269799011468 conserved nucleotide sequence; Gmet_P3386 269799011469 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 269799011470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269799011471 S-adenosylmethionine binding site [chemical binding]; other site 269799011472 RNA methyltransferase, RsmE family; Region: TIGR00046 269799011473 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 269799011474 conserved nucleotide sequence; Gmet_R4005 269799011475 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 269799011476 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 269799011477 catalytic site [active] 269799011478 putative active site [active] 269799011479 putative substrate binding site [chemical binding]; other site 269799011480 HRDC domain; Region: HRDC; pfam00570 269799011481 HRDC domain; Region: HRDC; pfam00570 269799011482 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 269799011483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799011484 FeS/SAM binding site; other site 269799011485 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 269799011486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799011487 FeS/SAM binding site; other site 269799011488 four heptanucleotide repeats; Gmet_H446 269799011489 aromatic acid decarboxylase; Validated; Region: PRK05920 269799011490 Flavoprotein; Region: Flavoprotein; pfam02441 269799011491 prenyltransferase; Reviewed; Region: ubiA; PRK12886 269799011492 UbiA prenyltransferase family; Region: UbiA; pfam01040 269799011493 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 269799011494 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 269799011495 tetramerization interface [polypeptide binding]; other site 269799011496 NAD(P) binding site [chemical binding]; other site 269799011497 catalytic residues [active] 269799011498 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799011499 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799011500 conserved nucleotide sequence; Gmet_I415 269799011501 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 269799011502 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 269799011503 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 269799011504 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 269799011505 Walker A motif; other site 269799011506 ATP binding site [chemical binding]; other site 269799011507 Walker B motif; other site 269799011508 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269799011509 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269799011510 Walker B motif; other site 269799011511 conserved nucleotide sequence; Gmet_P3402 269799011512 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 269799011513 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 269799011514 Ligand Binding Site [chemical binding]; other site 269799011515 'integration host factor binding site, putative; Gmet_I221A' 269799011516 'integration host factor binding site, putative; Gmet_I221B' 269799011517 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 269799011518 Transglycosylase; Region: Transgly; pfam00912 269799011519 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 269799011520 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 269799011521 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 269799011522 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 269799011523 gamma subunit interface [polypeptide binding]; other site 269799011524 epsilon subunit interface [polypeptide binding]; other site 269799011525 LBP interface [polypeptide binding]; other site 269799011526 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 269799011527 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 269799011528 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 269799011529 alpha subunit interaction interface [polypeptide binding]; other site 269799011530 Walker A motif; other site 269799011531 ATP binding site [chemical binding]; other site 269799011532 Walker B motif; other site 269799011533 inhibitor binding site; inhibition site 269799011534 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 269799011535 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 269799011536 core domain interface [polypeptide binding]; other site 269799011537 delta subunit interface [polypeptide binding]; other site 269799011538 epsilon subunit interface [polypeptide binding]; other site 269799011539 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 269799011540 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 269799011541 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 269799011542 beta subunit interaction interface [polypeptide binding]; other site 269799011543 Walker A motif; other site 269799011544 ATP binding site [chemical binding]; other site 269799011545 Walker B motif; other site 269799011546 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 269799011547 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 269799011548 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 269799011549 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 269799011550 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 269799011551 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 269799011552 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 269799011553 ParB-like nuclease domain; Region: ParB; smart00470 269799011554 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 269799011555 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 269799011556 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269799011557 Magnesium ion binding site [ion binding]; other site 269799011558 Response regulator receiver domain; Region: Response_reg; pfam00072 269799011559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799011560 active site 269799011561 phosphorylation site [posttranslational modification] 269799011562 intermolecular recognition site; other site 269799011563 dimerization interface [polypeptide binding]; other site 269799011564 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 269799011565 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 269799011566 G1 box; other site 269799011567 putative GEF interaction site [polypeptide binding]; other site 269799011568 GTP/Mg2+ binding site [chemical binding]; other site 269799011569 Switch I region; other site 269799011570 G2 box; other site 269799011571 G3 box; other site 269799011572 Switch II region; other site 269799011573 G4 box; other site 269799011574 G5 box; other site 269799011575 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 269799011576 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 269799011577 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 269799011578 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 269799011579 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269799011580 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269799011581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799011582 Walker A/P-loop; other site 269799011583 ATP binding site [chemical binding]; other site 269799011584 Q-loop/lid; other site 269799011585 ABC transporter signature motif; other site 269799011586 Walker B; other site 269799011587 D-loop; other site 269799011588 H-loop/switch region; other site 269799011589 conserved nucleotide sequence; Gmet_I416 269799011590 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 269799011591 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 269799011592 G1 box; other site 269799011593 GTP/Mg2+ binding site [chemical binding]; other site 269799011594 G2 box; other site 269799011595 Switch I region; other site 269799011596 G3 box; other site 269799011597 Switch II region; other site 269799011598 G4 box; other site 269799011599 G5 box; other site 269799011600 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 269799011601 conserved nucleotide sequence; Gmet_P3418 269799011602 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 269799011603 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 269799011604 dimer interface [polypeptide binding]; other site 269799011605 PYR/PP interface [polypeptide binding]; other site 269799011606 TPP binding site [chemical binding]; other site 269799011607 substrate binding site [chemical binding]; other site 269799011608 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 269799011609 Domain of unknown function; Region: EKR; pfam10371 269799011610 4Fe-4S binding domain; Region: Fer4_6; pfam12837 269799011611 4Fe-4S binding domain; Region: Fer4_6; pfam12837 269799011612 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 269799011613 TPP-binding site [chemical binding]; other site 269799011614 dimer interface [polypeptide binding]; other site 269799011615 conserved nucleotide sequence; Gmet_R4006 269799011616 recombination protein RecR; Reviewed; Region: recR; PRK00076 269799011617 RecR protein; Region: RecR; pfam02132 269799011618 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 269799011619 putative active site [active] 269799011620 putative metal-binding site [ion binding]; other site 269799011621 tetramer interface [polypeptide binding]; other site 269799011622 hypothetical protein; Validated; Region: PRK00153 269799011623 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 269799011624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269799011625 Walker A motif; other site 269799011626 ATP binding site [chemical binding]; other site 269799011627 Walker B motif; other site 269799011628 arginine finger; other site 269799011629 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 269799011630 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 269799011631 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269799011632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269799011633 Walker A/P-loop; other site 269799011634 ATP binding site [chemical binding]; other site 269799011635 Q-loop/lid; other site 269799011636 ABC transporter signature motif; other site 269799011637 Walker B; other site 269799011638 D-loop; other site 269799011639 H-loop/switch region; other site 269799011640 conserved nucleotide sequence; Gmet_R0145 269799011641 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 269799011642 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 269799011643 Cysteine-rich domain; Region: CCG; pfam02754 269799011644 Cysteine-rich domain; Region: CCG; pfam02754 269799011645 'integration host factor binding site, putative; Gmet_I222A' 269799011646 'integration host factor binding site, putative; Gmet_I222B' 269799011647 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 269799011648 conserved nucleotide sequence; Gmet_R6004 269799011649 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 269799011650 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 269799011651 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 269799011652 'integration host factor binding site, putative; Gmet_I124A' 269799011653 'integration host factor binding site, putative; Gmet_I124B' 269799011654 Transposase; Region: DEDD_Tnp_IS110; pfam01548 269799011655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 269799011656 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 269799011657 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 269799011658 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 269799011659 4Fe-4S binding domain; Region: Fer4; cl02805 269799011660 four heptanucleotide repeats; Gmet_H447 269799011661 four heptanucleotide repeats; Gmet_H448 269799011662 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 269799011663 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 269799011664 FAD binding pocket [chemical binding]; other site 269799011665 FAD binding motif [chemical binding]; other site 269799011666 phosphate binding motif [ion binding]; other site 269799011667 beta-alpha-beta structure motif; other site 269799011668 NAD binding pocket [chemical binding]; other site 269799011669 Iron coordination center [ion binding]; other site 269799011670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799011671 dimer interface [polypeptide binding]; other site 269799011672 phosphorylation site [posttranslational modification] 269799011673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799011674 ATP binding site [chemical binding]; other site 269799011675 Mg2+ binding site [ion binding]; other site 269799011676 G-X-G motif; other site 269799011677 'integration host factor binding site, putative; Gmet_I308A' 269799011678 'integration host factor binding site, putative; Gmet_I308B' 269799011679 hypothetical protein; Provisional; Region: PRK07550 269799011680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269799011681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799011682 homodimer interface [polypeptide binding]; other site 269799011683 catalytic residue [active] 269799011684 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 269799011685 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 269799011686 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 269799011687 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269799011688 RNA binding surface [nucleotide binding]; other site 269799011689 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 269799011690 active site 269799011691 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 269799011692 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269799011693 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269799011694 protein binding site [polypeptide binding]; other site 269799011695 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269799011696 protein binding site [polypeptide binding]; other site 269799011697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269799011698 sequence-specific DNA binding site [nucleotide binding]; other site 269799011699 salt bridge; other site 269799011700 Cupin domain; Region: Cupin_2; pfam07883 269799011701 PilZ domain; Region: PilZ; pfam07238 269799011702 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 269799011703 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 269799011704 metal binding site [ion binding]; metal-binding site 269799011705 putative dimer interface [polypeptide binding]; other site 269799011706 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 269799011707 FMN binding site [chemical binding]; other site 269799011708 dimer interface [polypeptide binding]; other site 269799011709 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 269799011710 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 269799011711 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 269799011712 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 269799011713 putative active site [active] 269799011714 putative CoA binding site [chemical binding]; other site 269799011715 nudix motif; other site 269799011716 metal binding site [ion binding]; metal-binding site 269799011717 Uncharacterized conserved protein [Function unknown]; Region: COG2353 269799011718 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 269799011719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 269799011720 dimerization interface [polypeptide binding]; other site 269799011721 putative Zn2+ binding site [ion binding]; other site 269799011722 putative DNA binding site [nucleotide binding]; other site 269799011723 Sulphur transport; Region: Sulf_transp; pfam04143 269799011724 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 269799011725 CPxP motif; other site 269799011726 PAS domain S-box; Region: sensory_box; TIGR00229 269799011727 PAS domain; Region: PAS; smart00091 269799011728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799011729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799011730 dimer interface [polypeptide binding]; other site 269799011731 phosphorylation site [posttranslational modification] 269799011732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799011733 ATP binding site [chemical binding]; other site 269799011734 Mg2+ binding site [ion binding]; other site 269799011735 G-X-G motif; other site 269799011736 EamA-like transporter family; Region: EamA; pfam00892 269799011737 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 269799011738 EamA-like transporter family; Region: EamA; pfam00892 269799011739 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 269799011740 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269799011741 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 269799011742 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 269799011743 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 269799011744 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 269799011745 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269799011746 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 269799011747 Walker A/P-loop; other site 269799011748 ATP binding site [chemical binding]; other site 269799011749 Q-loop/lid; other site 269799011750 ABC transporter signature motif; other site 269799011751 Walker B; other site 269799011752 D-loop; other site 269799011753 H-loop/switch region; other site 269799011754 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 269799011755 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 269799011756 Walker A/P-loop; other site 269799011757 ATP binding site [chemical binding]; other site 269799011758 Q-loop/lid; other site 269799011759 ABC transporter signature motif; other site 269799011760 Walker B; other site 269799011761 D-loop; other site 269799011762 H-loop/switch region; other site 269799011763 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 269799011764 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269799011765 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 269799011766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 269799011767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 269799011768 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 269799011769 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 269799011770 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 269799011771 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 269799011772 catalytic site [active] 269799011773 active site 269799011774 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 269799011775 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 269799011776 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 269799011777 active site 269799011778 catalytic site [active] 269799011779 trehalose synthase; Region: treS_nterm; TIGR02456 269799011780 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 269799011781 active site 269799011782 catalytic site [active] 269799011783 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 269799011784 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 269799011785 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 269799011786 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 269799011787 Cl- selectivity filter; other site 269799011788 Cl- binding residues [ion binding]; other site 269799011789 pore gating glutamate residue; other site 269799011790 dimer interface [polypeptide binding]; other site 269799011791 FOG: CBS domain [General function prediction only]; Region: COG0517 269799011792 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 269799011793 conserved nucleotide sequence; Gmet_R0146 269799011794 Response regulator receiver domain; Region: Response_reg; pfam00072 269799011795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799011796 active site 269799011797 phosphorylation site [posttranslational modification] 269799011798 intermolecular recognition site; other site 269799011799 dimerization interface [polypeptide binding]; other site 269799011800 Response regulator receiver domain; Region: Response_reg; pfam00072 269799011801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799011802 active site 269799011803 phosphorylation site [posttranslational modification] 269799011804 intermolecular recognition site; other site 269799011805 dimerization interface [polypeptide binding]; other site 269799011806 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 269799011807 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 269799011808 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 269799011809 Walker A motif; other site 269799011810 ATP binding site [chemical binding]; other site 269799011811 Walker B motif; other site 269799011812 Double zinc ribbon; Region: DZR; pfam12773 269799011813 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 269799011814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799011815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799011816 ATP binding site [chemical binding]; other site 269799011817 Mg2+ binding site [ion binding]; other site 269799011818 G-X-G motif; other site 269799011819 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 269799011820 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 269799011821 G1 box; other site 269799011822 GTP/Mg2+ binding site [chemical binding]; other site 269799011823 G2 box; other site 269799011824 Switch I region; other site 269799011825 G3 box; other site 269799011826 Switch II region; other site 269799011827 G4 box; other site 269799011828 G5 box; other site 269799011829 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 269799011830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799011831 active site 269799011832 phosphorylation site [posttranslational modification] 269799011833 intermolecular recognition site; other site 269799011834 dimerization interface [polypeptide binding]; other site 269799011835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269799011836 Zn2+ binding site [ion binding]; other site 269799011837 Mg2+ binding site [ion binding]; other site 269799011838 Cache domain; Region: Cache_1; pfam02743 269799011839 HAMP domain; Region: HAMP; pfam00672 269799011840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799011841 PAS fold; Region: PAS_3; pfam08447 269799011842 putative active site [active] 269799011843 heme pocket [chemical binding]; other site 269799011844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799011845 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 269799011846 putative active site [active] 269799011847 heme pocket [chemical binding]; other site 269799011848 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799011849 putative active site [active] 269799011850 heme pocket [chemical binding]; other site 269799011851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799011852 putative active site [active] 269799011853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 269799011854 heme pocket [chemical binding]; other site 269799011855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799011856 dimer interface [polypeptide binding]; other site 269799011857 phosphorylation site [posttranslational modification] 269799011858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799011859 ATP binding site [chemical binding]; other site 269799011860 Mg2+ binding site [ion binding]; other site 269799011861 G-X-G motif; other site 269799011862 Response regulator receiver domain; Region: Response_reg; pfam00072 269799011863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269799011864 active site 269799011865 phosphorylation site [posttranslational modification] 269799011866 intermolecular recognition site; other site 269799011867 dimerization interface [polypeptide binding]; other site 269799011868 PAS domain; Region: PAS_8; pfam13188 269799011869 PAS fold; Region: PAS; pfam00989 269799011870 Cache domain; Region: Cache_1; pfam02743 269799011871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269799011872 dimerization interface [polypeptide binding]; other site 269799011873 PAS domain S-box; Region: sensory_box; TIGR00229 269799011874 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 269799011875 putative active site [active] 269799011876 heme pocket [chemical binding]; other site 269799011877 PAS domain; Region: PAS; smart00091 269799011878 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 269799011879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269799011880 dimer interface [polypeptide binding]; other site 269799011881 phosphorylation site [posttranslational modification] 269799011882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269799011883 ATP binding site [chemical binding]; other site 269799011884 Mg2+ binding site [ion binding]; other site 269799011885 G-X-G motif; other site 269799011886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 269799011887 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799011888 conserved nucleotide sequence; Gmet_R0147 269799011889 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 269799011890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269799011891 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 269799011892 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 269799011893 active site residue [active] 269799011894 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 269799011895 Sporulation related domain; Region: SPOR; pfam05036 269799011896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799011897 binding surface 269799011898 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269799011899 TPR motif; other site 269799011900 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 269799011901 Ion channel; Region: Ion_trans_2; pfam07885 269799011902 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 269799011903 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 269799011904 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 269799011905 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 269799011906 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 269799011907 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269799011908 catalytic loop [active] 269799011909 iron binding site [ion binding]; other site 269799011910 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 269799011911 Protein of unknown function, DUF488; Region: DUF488; pfam04343 269799011912 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 269799011913 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 269799011914 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 269799011915 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 269799011916 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 269799011917 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 269799011918 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 269799011919 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 269799011920 palindrome; Gmet_R0148 269799011921 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 269799011922 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 269799011923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 269799011924 Soluble P-type ATPase [General function prediction only]; Region: COG4087 269799011925 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 269799011926 Ligand Binding Site [chemical binding]; other site 269799011927 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 269799011928 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799011929 ligand binding site [chemical binding]; other site 269799011930 conserved nucleotide sequence; Gmet_I417 269799011931 conserved nucleotide sequence; Gmet_I418 269799011932 palindrome; Gmet_R0149 269799011933 conserved nucleotide sequence; Gmet_P3502 269799011934 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 269799011935 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 269799011936 tetramer interface [polypeptide binding]; other site 269799011937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269799011938 catalytic residue [active] 269799011939 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 269799011940 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 269799011941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799011942 FeS/SAM binding site; other site 269799011943 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 269799011944 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 269799011945 active site 269799011946 dimer interface [polypeptide binding]; other site 269799011947 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 269799011948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269799011949 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 269799011950 HlyD family secretion protein; Region: HlyD_3; pfam13437 269799011951 conserved nucleotide sequence; Gmet_I419 269799011952 conserved nucleotide sequence; Gmet_I420 269799011953 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 269799011954 This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078 269799011955 conserved nucleotide sequence; Gmet_R0150 269799011956 Proline dehydrogenase; Region: Pro_dh; cl03282 269799011957 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 269799011958 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 269799011959 Glutamate binding site [chemical binding]; other site 269799011960 homodimer interface [polypeptide binding]; other site 269799011961 NAD binding site [chemical binding]; other site 269799011962 catalytic residues [active] 269799011963 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 269799011964 putative catalytic residues [active] 269799011965 Carbonic anhydrase; Region: Pro_CA; smart00947 269799011966 active site clefts [active] 269799011967 zinc binding site [ion binding]; other site 269799011968 dimer interface [polypeptide binding]; other site 269799011969 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 269799011970 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 269799011971 Predicted membrane protein [Function unknown]; Region: COG4881 269799011972 OmpW family; Region: OmpW; cl17427 269799011973 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 269799011974 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 269799011975 conserved cys residue [active] 269799011976 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 269799011977 nucleoside/Zn binding site; other site 269799011978 dimer interface [polypeptide binding]; other site 269799011979 catalytic motif [active] 269799011980 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 269799011981 Transposase; Region: DDE_Tnp_ISL3; pfam01610 269799011982 seryl-tRNA synthetase; Provisional; Region: PRK05431 269799011983 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 269799011984 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 269799011985 dimer interface [polypeptide binding]; other site 269799011986 active site 269799011987 motif 1; other site 269799011988 motif 2; other site 269799011989 motif 3; other site 269799011990 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 269799011991 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 269799011992 putative active site [active] 269799011993 putative metal binding site [ion binding]; other site 269799011994 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 269799011995 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 269799011996 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 269799011997 chaperone protein DnaJ; Provisional; Region: PRK10767 269799011998 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269799011999 HSP70 interaction site [polypeptide binding]; other site 269799012000 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 269799012001 substrate binding site [polypeptide binding]; other site 269799012002 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 269799012003 Zn binding sites [ion binding]; other site 269799012004 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 269799012005 dimer interface [polypeptide binding]; other site 269799012006 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 269799012007 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 269799012008 nucleotide binding site [chemical binding]; other site 269799012009 NEF interaction site [polypeptide binding]; other site 269799012010 SBD interface [polypeptide binding]; other site 269799012011 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 269799012012 GrpE; Region: GrpE; pfam01025 269799012013 dimer interface [polypeptide binding]; other site 269799012014 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 269799012015 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 269799012016 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 269799012017 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 269799012018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269799012019 FeS/SAM binding site; other site 269799012020 HemN C-terminal domain; Region: HemN_C; pfam06969 269799012021 Predicted amidohydrolase [General function prediction only]; Region: COG0388 269799012022 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 269799012023 putative active site [active] 269799012024 catalytic triad [active] 269799012025 putative dimer interface [polypeptide binding]; other site 269799012026 TolQ protein; Region: tolQ; TIGR02796 269799012027 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 269799012028 TolR protein; Region: tolR; TIGR02801 269799012029 TonB C terminal; Region: TonB_2; pfam13103 269799012030 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 269799012031 TolB amino-terminal domain; Region: TolB_N; pfam04052 269799012032 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 269799012033 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 269799012034 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 269799012035 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 269799012036 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 269799012037 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269799012038 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269799012039 ligand binding site [chemical binding]; other site 269799012040 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 269799012041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269799012042 binding surface 269799012043 TPR motif; other site 269799012044 twin arginine translocase protein A; Provisional; Region: tatA; PRK14858 269799012045 Quinolinate synthetase A protein; Region: NadA; pfam02445 269799012046 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 269799012047 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 269799012048 trimer interface [polypeptide binding]; other site 269799012049 putative metal binding site [ion binding]; other site 269799012050 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 269799012051 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799012052 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799012053 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269799012054 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 269799012055 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 269799012056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269799012057 ATP binding site [chemical binding]; other site 269799012058 putative Mg++ binding site [ion binding]; other site 269799012059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269799012060 nucleotide binding region [chemical binding]; other site 269799012061 ATP-binding site [chemical binding]; other site 269799012062 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 269799012063 SurA N-terminal domain; Region: SurA_N_3; cl07813 269799012064 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 269799012065 putative peptidyl-prolyl cis-trans isomerase, LIC12922 family; Region: PCisTranLspir; TIGR04142 269799012066 SurA N-terminal domain; Region: SurA_N; pfam09312 269799012067 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 269799012068 four heptanucleotide repeats; Gmet_H449 269799012069 chaperone protein DnaJ; Provisional; Region: PRK14299 269799012070 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269799012071 HSP70 interaction site [polypeptide binding]; other site 269799012072 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 269799012073 substrate binding site [polypeptide binding]; other site 269799012074 dimer interface [polypeptide binding]; other site 269799012075 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 269799012076 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269799012077 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 269799012078 active site 269799012079 catalytic residues [active] 269799012080 metal binding site [ion binding]; metal-binding site 269799012081 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 269799012082 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 269799012083 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 269799012084 Membrane protein of unknown function; Region: DUF360; pfam04020 269799012085 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 269799012086 active site 269799012087 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 269799012088 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 269799012089 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 269799012090 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 269799012091 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 269799012092 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 269799012093 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 269799012094 trmE is a tRNA modification GTPase; Region: trmE; cd04164 269799012095 G1 box; other site 269799012096 GTP/Mg2+ binding site [chemical binding]; other site 269799012097 Switch I region; other site 269799012098 G2 box; other site 269799012099 Switch II region; other site 269799012100 G3 box; other site 269799012101 G4 box; other site 269799012102 G5 box; other site 269799012103 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 269799012104 membrane protein insertase; Provisional; Region: PRK01318 269799012105 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 269799012106 Haemolytic domain; Region: Haemolytic; pfam01809 269799012107 Ribonuclease P; Region: Ribonuclease_P; cl00457 269799012108 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399