-- dump date 20140619_102645 -- class Genbank::misc_feature -- table misc_feature_note -- id note 526225000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 526225000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 526225000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225000004 Walker A motif; other site 526225000005 ATP binding site [chemical binding]; other site 526225000006 Walker B motif; other site 526225000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 526225000008 arginine finger; other site 526225000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 526225000010 DnaA box-binding interface [nucleotide binding]; other site 526225000011 DNA polymerase III subunit beta; Validated; Region: PRK07761 526225000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 526225000013 putative DNA binding surface [nucleotide binding]; other site 526225000014 dimer interface [polypeptide binding]; other site 526225000015 beta-clamp/clamp loader binding surface; other site 526225000016 beta-clamp/translesion DNA polymerase binding surface; other site 526225000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 526225000018 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 526225000019 recombination protein F; Reviewed; Region: recF; PRK00064 526225000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 526225000021 Walker A/P-loop; other site 526225000022 ATP binding site [chemical binding]; other site 526225000023 Q-loop/lid; other site 526225000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225000025 ABC transporter signature motif; other site 526225000026 Walker B; other site 526225000027 D-loop; other site 526225000028 H-loop/switch region; other site 526225000029 Protein of unknown function (DUF721); Region: DUF721; cl02324 526225000030 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526225000031 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 526225000032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225000033 Walker A/P-loop; other site 526225000034 ATP binding site [chemical binding]; other site 526225000035 Q-loop/lid; other site 526225000036 ABC transporter signature motif; other site 526225000037 Walker B; other site 526225000038 D-loop; other site 526225000039 H-loop/switch region; other site 526225000040 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 526225000041 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 526225000042 putative NAD(P) binding site [chemical binding]; other site 526225000043 putative active site [active] 526225000044 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 526225000045 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 526225000046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225000047 ATP binding site [chemical binding]; other site 526225000048 Mg2+ binding site [ion binding]; other site 526225000049 G-X-G motif; other site 526225000050 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 526225000051 anchoring element; other site 526225000052 dimer interface [polypeptide binding]; other site 526225000053 ATP binding site [chemical binding]; other site 526225000054 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 526225000055 active site 526225000056 putative metal-binding site [ion binding]; other site 526225000057 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 526225000058 DNA gyrase subunit A; Validated; Region: PRK05560 526225000059 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 526225000060 CAP-like domain; other site 526225000061 active site 526225000062 primary dimer interface [polypeptide binding]; other site 526225000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526225000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526225000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526225000066 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526225000067 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526225000068 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 526225000069 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 526225000070 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225000071 Helix-turn-helix domain; Region: HTH_17; cl17695 526225000072 TrwC relaxase; Region: TrwC; pfam08751 526225000073 AAA domain; Region: AAA_30; pfam13604 526225000074 Family description; Region: UvrD_C_2; pfam13538 526225000075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225000076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225000077 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 526225000078 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225000079 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 526225000080 putative NAD(P) binding site [chemical binding]; other site 526225000081 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225000082 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 526225000083 Walker A/P-loop; other site 526225000084 ATP binding site [chemical binding]; other site 526225000085 Q-loop/lid; other site 526225000086 ABC transporter signature motif; other site 526225000087 Walker B; other site 526225000088 D-loop; other site 526225000089 H-loop/switch region; other site 526225000090 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 526225000091 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526225000092 Coenzyme A binding pocket [chemical binding]; other site 526225000093 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 526225000094 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 526225000095 tandem repeat interface [polypeptide binding]; other site 526225000096 oligomer interface [polypeptide binding]; other site 526225000097 active site residues [active] 526225000098 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 526225000099 active site 526225000100 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 526225000101 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526225000102 dimer interface [polypeptide binding]; other site 526225000103 active site 526225000104 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 526225000105 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 526225000106 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 526225000107 Glutamine amidotransferase class-I; Region: GATase; pfam00117 526225000108 glutamine binding [chemical binding]; other site 526225000109 catalytic triad [active] 526225000110 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526225000111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225000112 active site 526225000113 ATP binding site [chemical binding]; other site 526225000114 substrate binding site [chemical binding]; other site 526225000115 activation loop (A-loop); other site 526225000116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 526225000117 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225000118 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225000119 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225000120 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225000121 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225000122 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225000123 active site 526225000124 ATP binding site [chemical binding]; other site 526225000125 substrate binding site [chemical binding]; other site 526225000126 activation loop (A-loop); other site 526225000127 PASTA domain; Region: PASTA; smart00740 526225000128 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 526225000129 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 526225000130 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 526225000131 active site 526225000132 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 526225000133 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 526225000134 phosphopeptide binding site; other site 526225000135 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 526225000136 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 526225000137 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 526225000138 phosphopeptide binding site; other site 526225000139 SnoaL-like domain; Region: SnoaL_2; pfam12680 526225000140 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 526225000141 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 526225000142 active site 526225000143 catalytic residues [active] 526225000144 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 526225000145 MOSC domain; Region: MOSC; pfam03473 526225000146 S4 domain; Region: S4_2; pfam13275 526225000147 aminotransferase; Validated; Region: PRK07777 526225000148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526225000149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225000150 homodimer interface [polypeptide binding]; other site 526225000151 catalytic residue [active] 526225000152 C-N hydrolase family amidase; Provisional; Region: PRK10438 526225000153 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 526225000154 active site 526225000155 catalytic triad [active] 526225000156 dimer interface [polypeptide binding]; other site 526225000157 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526225000158 active site 526225000159 PRC-barrel domain; Region: PRC; pfam05239 526225000160 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 526225000161 putative active site; other site 526225000162 putative metal binding residues [ion binding]; other site 526225000163 signature motif; other site 526225000164 putative triphosphate binding site [ion binding]; other site 526225000165 CHAD domain; Region: CHAD; pfam05235 526225000166 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 526225000167 putative active site [active] 526225000168 putative metal binding site [ion binding]; other site 526225000169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225000170 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 526225000171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225000172 DNA-binding site [nucleotide binding]; DNA binding site 526225000173 UTRA domain; Region: UTRA; pfam07702 526225000174 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526225000175 hydrophobic ligand binding site; other site 526225000176 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 526225000177 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 526225000178 enoyl-CoA hydratase; Provisional; Region: PRK08140 526225000179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225000180 substrate binding site [chemical binding]; other site 526225000181 oxyanion hole (OAH) forming residues; other site 526225000182 trimer interface [polypeptide binding]; other site 526225000183 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225000184 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225000185 active site 526225000186 ATP binding site [chemical binding]; other site 526225000187 substrate binding site [chemical binding]; other site 526225000188 activation loop (A-loop); other site 526225000189 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225000190 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225000191 active site 526225000192 ATP binding site [chemical binding]; other site 526225000193 substrate binding site [chemical binding]; other site 526225000194 activation loop (A-loop); other site 526225000195 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225000196 competence damage-inducible protein A; Provisional; Region: PRK00549 526225000197 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 526225000198 MPT binding site; other site 526225000199 Competence-damaged protein; Region: CinA; pfam02464 526225000200 Cupin domain; Region: Cupin_2; pfam07883 526225000201 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526225000202 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526225000203 Domain of unknown function (DUF222); Region: DUF222; pfam02720 526225000204 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526225000205 active site 526225000206 PAS fold; Region: PAS_4; pfam08448 526225000207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225000208 putative active site [active] 526225000209 heme pocket [chemical binding]; other site 526225000210 PAS fold; Region: PAS_4; pfam08448 526225000211 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225000212 metal binding site [ion binding]; metal-binding site 526225000213 active site 526225000214 I-site; other site 526225000215 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225000216 LabA_like proteins; Region: LabA_like; cd06167 526225000217 putative metal binding site [ion binding]; other site 526225000218 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 526225000219 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 526225000220 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 526225000221 putative active site [active] 526225000222 putative active site [active] 526225000223 catalytic site [active] 526225000224 catalytic site [active] 526225000225 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 526225000226 putative active site [active] 526225000227 catalytic site [active] 526225000228 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 526225000229 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 526225000230 PAS domain; Region: PAS; smart00091 526225000231 PAS domain S-box; Region: sensory_box; TIGR00229 526225000232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225000233 putative active site [active] 526225000234 heme pocket [chemical binding]; other site 526225000235 GAF domain; Region: GAF_2; pfam13185 526225000236 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225000237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225000238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225000239 metal binding site [ion binding]; metal-binding site 526225000240 active site 526225000241 I-site; other site 526225000242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225000243 PilZ domain; Region: PilZ; pfam07238 526225000244 PilZ domain; Region: PilZ; pfam07238 526225000245 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 526225000246 G1 box; other site 526225000247 GTP/Mg2+ binding site [chemical binding]; other site 526225000248 G2 box; other site 526225000249 Switch I region; other site 526225000250 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 526225000251 G1 box; other site 526225000252 GTP/Mg2+ binding site [chemical binding]; other site 526225000253 G2 box; other site 526225000254 Switch I region; other site 526225000255 G3 box; other site 526225000256 Switch II region; other site 526225000257 G4 box; other site 526225000258 G5 box; other site 526225000259 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225000260 GAF domain; Region: GAF; pfam01590 526225000261 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 526225000262 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 526225000263 active site 526225000264 amino acid transporter; Region: 2A0306; TIGR00909 526225000265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225000266 PAS fold; Region: PAS_3; pfam08447 526225000267 putative active site [active] 526225000268 heme pocket [chemical binding]; other site 526225000269 PAS domain; Region: PAS; smart00091 526225000270 PAS fold; Region: PAS_4; pfam08448 526225000271 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225000272 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225000273 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526225000274 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 526225000275 intersubunit interface [polypeptide binding]; other site 526225000276 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 526225000277 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 526225000278 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 526225000279 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 526225000280 active site 526225000281 thiamine phosphate binding site [chemical binding]; other site 526225000282 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 526225000283 ThiS interaction site; other site 526225000284 putative active site [active] 526225000285 tetramer interface [polypeptide binding]; other site 526225000286 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 526225000287 thiS-thiF/thiG interaction site; other site 526225000288 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 526225000289 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526225000290 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 526225000291 Na binding site [ion binding]; other site 526225000292 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 526225000293 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 526225000294 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 526225000295 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 526225000296 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 526225000297 Uncharacterized conserved protein [Function unknown]; Region: COG1656 526225000298 Protein of unknown function DUF82; Region: DUF82; pfam01927 526225000299 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 526225000300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225000301 putative active site [active] 526225000302 putative metal binding site [ion binding]; other site 526225000303 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526225000304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526225000305 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526225000306 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 526225000307 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 526225000308 catalytic site [active] 526225000309 methionine sulfoxide reductase A; Provisional; Region: PRK00058 526225000310 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 526225000311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225000312 S-adenosylmethionine binding site [chemical binding]; other site 526225000313 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225000314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225000315 S-adenosylmethionine binding site [chemical binding]; other site 526225000316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526225000317 dimerization interface [polypeptide binding]; other site 526225000318 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 526225000319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526225000320 dimer interface [polypeptide binding]; other site 526225000321 putative CheW interface [polypeptide binding]; other site 526225000322 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 526225000323 active site 526225000324 homotetramer interface [polypeptide binding]; other site 526225000325 putative OHCU decarboxylase; Provisional; Region: PRK13798 526225000326 GAF domain; Region: GAF_3; pfam13492 526225000327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225000328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225000329 dimer interface [polypeptide binding]; other site 526225000330 phosphorylation site [posttranslational modification] 526225000331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225000332 ATP binding site [chemical binding]; other site 526225000333 Mg2+ binding site [ion binding]; other site 526225000334 G-X-G motif; other site 526225000335 Response regulator receiver domain; Region: Response_reg; pfam00072 526225000336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225000337 active site 526225000338 phosphorylation site [posttranslational modification] 526225000339 intermolecular recognition site; other site 526225000340 dimerization interface [polypeptide binding]; other site 526225000341 PAS domain S-box; Region: sensory_box; TIGR00229 526225000342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225000343 putative active site [active] 526225000344 heme pocket [chemical binding]; other site 526225000345 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225000346 GAF domain; Region: GAF_2; pfam13185 526225000347 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225000348 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225000349 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 526225000350 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225000351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225000352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225000353 putative Zn2+ binding site [ion binding]; other site 526225000354 putative DNA binding site [nucleotide binding]; other site 526225000355 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 526225000356 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 526225000357 active site 526225000358 DNA binding site [nucleotide binding] 526225000359 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 526225000360 DNA binding site [nucleotide binding] 526225000361 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 526225000362 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 526225000363 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 526225000364 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 526225000365 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 526225000366 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 526225000367 FAD binding domain; Region: FAD_binding_4; pfam01565 526225000368 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 526225000369 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 526225000370 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 526225000371 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 526225000372 MarR family; Region: MarR; pfam01047 526225000373 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526225000374 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526225000375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225000376 Walker A/P-loop; other site 526225000377 ATP binding site [chemical binding]; other site 526225000378 Q-loop/lid; other site 526225000379 ABC transporter signature motif; other site 526225000380 Walker B; other site 526225000381 D-loop; other site 526225000382 H-loop/switch region; other site 526225000383 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526225000384 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 526225000385 active site 526225000386 catalytic site [active] 526225000387 RibD C-terminal domain; Region: RibD_C; cl17279 526225000388 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225000389 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 526225000390 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 526225000391 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 526225000392 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526225000393 catalytic residue [active] 526225000394 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225000395 active site 526225000396 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225000397 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 526225000398 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 526225000399 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225000400 Cytochrome P450; Region: p450; cl12078 526225000401 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 526225000402 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 526225000403 hypothetical protein; Provisional; Region: PRK06184 526225000404 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225000405 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 526225000406 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 526225000407 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 526225000408 active site 526225000409 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 526225000410 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 526225000411 dimer interface [polypeptide binding]; other site 526225000412 active site 526225000413 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 526225000414 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 526225000415 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 526225000416 putative hydrophobic ligand binding site [chemical binding]; other site 526225000417 active site 526225000418 catalytic residues_2 [active] 526225000419 catalytic residues_1 [active] 526225000420 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 526225000421 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 526225000422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526225000423 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225000424 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 526225000425 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526225000426 carboxyltransferase (CT) interaction site; other site 526225000427 biotinylation site [posttranslational modification]; other site 526225000428 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 526225000429 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 526225000430 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 526225000431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225000432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225000433 active site 526225000434 phosphorylation site [posttranslational modification] 526225000435 intermolecular recognition site; other site 526225000436 dimerization interface [polypeptide binding]; other site 526225000437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225000438 DNA binding residues [nucleotide binding] 526225000439 dimerization interface [polypeptide binding]; other site 526225000440 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225000441 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225000442 DNA binding residues [nucleotide binding] 526225000443 dimerization interface [polypeptide binding]; other site 526225000444 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 526225000445 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 526225000446 FMN binding site [chemical binding]; other site 526225000447 active site 526225000448 substrate binding site [chemical binding]; other site 526225000449 catalytic residue [active] 526225000450 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225000451 MarR family; Region: MarR; pfam01047 526225000452 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 526225000453 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526225000454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225000455 Walker A/P-loop; other site 526225000456 ATP binding site [chemical binding]; other site 526225000457 Q-loop/lid; other site 526225000458 ABC transporter signature motif; other site 526225000459 Walker B; other site 526225000460 D-loop; other site 526225000461 H-loop/switch region; other site 526225000462 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526225000463 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 526225000464 Walker A/P-loop; other site 526225000465 ATP binding site [chemical binding]; other site 526225000466 Q-loop/lid; other site 526225000467 ABC transporter signature motif; other site 526225000468 Walker B; other site 526225000469 D-loop; other site 526225000470 H-loop/switch region; other site 526225000471 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225000472 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225000473 short chain dehydrogenase; Provisional; Region: PRK06197 526225000474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225000475 NAD(P) binding site [chemical binding]; other site 526225000476 active site 526225000477 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 526225000478 putative hydrophobic ligand binding site [chemical binding]; other site 526225000479 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 526225000480 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 526225000481 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526225000482 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 526225000483 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225000484 catalytic loop [active] 526225000485 iron binding site [ion binding]; other site 526225000486 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 526225000487 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 526225000488 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 526225000489 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 526225000490 CoA-ligase; Region: Ligase_CoA; pfam00549 526225000491 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 526225000492 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 526225000493 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 526225000494 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 526225000495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526225000496 RNA binding surface [nucleotide binding]; other site 526225000497 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 526225000498 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 526225000499 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 526225000500 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 526225000501 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526225000502 dimer interface [polypeptide binding]; other site 526225000503 putative CheW interface [polypeptide binding]; other site 526225000504 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 526225000505 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 526225000506 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 526225000507 putative substrate binding site [chemical binding]; other site 526225000508 nucleotide binding site [chemical binding]; other site 526225000509 nucleotide binding site [chemical binding]; other site 526225000510 homodimer interface [polypeptide binding]; other site 526225000511 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 526225000512 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 526225000513 active site 526225000514 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 526225000515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225000516 ATP binding site [chemical binding]; other site 526225000517 putative Mg++ binding site [ion binding]; other site 526225000518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225000519 nucleotide binding region [chemical binding]; other site 526225000520 ATP-binding site [chemical binding]; other site 526225000521 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 526225000522 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 526225000523 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526225000524 Walker A/P-loop; other site 526225000525 ATP binding site [chemical binding]; other site 526225000526 Q-loop/lid; other site 526225000527 ABC transporter signature motif; other site 526225000528 Walker B; other site 526225000529 D-loop; other site 526225000530 H-loop/switch region; other site 526225000531 Predicted transcriptional regulators [Transcription]; Region: COG1725 526225000532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225000533 DNA-binding site [nucleotide binding]; DNA binding site 526225000534 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 526225000535 alpha-gamma subunit interface [polypeptide binding]; other site 526225000536 beta-gamma subunit interface [polypeptide binding]; other site 526225000537 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 526225000538 gamma-beta subunit interface [polypeptide binding]; other site 526225000539 alpha-beta subunit interface [polypeptide binding]; other site 526225000540 urease subunit alpha; Reviewed; Region: ureC; PRK13206 526225000541 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 526225000542 subunit interactions [polypeptide binding]; other site 526225000543 active site 526225000544 flap region; other site 526225000545 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 526225000546 UreD urease accessory protein; Region: UreD; cl00530 526225000547 allantoicase; Provisional; Region: PRK13257 526225000548 Allantoicase repeat; Region: Allantoicase; pfam03561 526225000549 Allantoicase repeat; Region: Allantoicase; pfam03561 526225000550 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 526225000551 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 526225000552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225000553 active site 526225000554 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526225000555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225000556 catalytic residue [active] 526225000557 Anti-sigma-K factor rskA; Region: RskA; pfam10099 526225000558 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 526225000559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225000560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225000561 DNA binding residues [nucleotide binding] 526225000562 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 526225000563 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 526225000564 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 526225000565 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 526225000566 putative active site [active] 526225000567 putative dimer interface [polypeptide binding]; other site 526225000568 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 526225000569 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 526225000570 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 526225000571 Domain of unknown function (DUF309); Region: DUF309; pfam03745 526225000572 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 526225000573 putative hydrophobic ligand binding site [chemical binding]; other site 526225000574 Predicted transcriptional regulators [Transcription]; Region: COG1695 526225000575 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 526225000576 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 526225000577 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 526225000578 Malic enzyme, N-terminal domain; Region: malic; pfam00390 526225000579 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 526225000580 putative NAD(P) binding site [chemical binding]; other site 526225000581 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 526225000582 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 526225000583 putative DNA binding site [nucleotide binding]; other site 526225000584 catalytic residue [active] 526225000585 putative H2TH interface [polypeptide binding]; other site 526225000586 putative catalytic residues [active] 526225000587 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 526225000588 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 526225000589 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 526225000590 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 526225000591 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 526225000592 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 526225000593 [2Fe-2S] cluster binding site [ion binding]; other site 526225000594 Protein of unknown function, DUF485; Region: DUF485; pfam04341 526225000595 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 526225000596 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 526225000597 Na binding site [ion binding]; other site 526225000598 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 526225000599 dimanganese center [ion binding]; other site 526225000600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225000601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225000602 ATP binding site [chemical binding]; other site 526225000603 Mg2+ binding site [ion binding]; other site 526225000604 G-X-G motif; other site 526225000605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225000606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225000607 DNA binding residues [nucleotide binding] 526225000608 dimerization interface [polypeptide binding]; other site 526225000609 Predicted membrane protein [Function unknown]; Region: COG3428 526225000610 Bacterial PH domain; Region: DUF304; pfam03703 526225000611 Bacterial PH domain; Region: DUF304; pfam03703 526225000612 Bacterial PH domain; Region: DUF304; cl01348 526225000613 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526225000614 active site residue [active] 526225000615 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 526225000616 Predicted membrane protein [Function unknown]; Region: COG2246 526225000617 GtrA-like protein; Region: GtrA; pfam04138 526225000618 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225000619 active site 526225000620 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225000621 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225000622 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 526225000623 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225000624 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 526225000625 DXD motif; other site 526225000626 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 526225000627 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 526225000628 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 526225000629 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 526225000630 dimer interface [polypeptide binding]; other site 526225000631 acyl-activating enzyme (AAE) consensus motif; other site 526225000632 putative active site [active] 526225000633 AMP binding site [chemical binding]; other site 526225000634 putative CoA binding site [chemical binding]; other site 526225000635 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225000636 Cytochrome P450; Region: p450; cl12078 526225000637 SEC-C motif; Region: SEC-C; pfam02810 526225000638 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 526225000639 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 526225000640 putative ligand binding site [chemical binding]; other site 526225000641 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 526225000642 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526225000643 Walker A/P-loop; other site 526225000644 ATP binding site [chemical binding]; other site 526225000645 Q-loop/lid; other site 526225000646 ABC transporter signature motif; other site 526225000647 Walker B; other site 526225000648 D-loop; other site 526225000649 H-loop/switch region; other site 526225000650 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 526225000651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225000652 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526225000653 TM-ABC transporter signature motif; other site 526225000654 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526225000655 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526225000656 DNA binding site [nucleotide binding] 526225000657 domain linker motif; other site 526225000658 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 526225000659 ligand binding site [chemical binding]; other site 526225000660 dimerization interface (open form) [polypeptide binding]; other site 526225000661 dimerization interface (closed form) [polypeptide binding]; other site 526225000662 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 526225000663 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 526225000664 putative N- and C-terminal domain interface [polypeptide binding]; other site 526225000665 putative active site [active] 526225000666 MgATP binding site [chemical binding]; other site 526225000667 catalytic site [active] 526225000668 metal binding site [ion binding]; metal-binding site 526225000669 putative carbohydrate binding site [chemical binding]; other site 526225000670 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 526225000671 intersubunit interface [polypeptide binding]; other site 526225000672 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 526225000673 active site 526225000674 Zn2+ binding site [ion binding]; other site 526225000675 L-arabinose isomerase; Provisional; Region: PRK02929 526225000676 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 526225000677 hexamer (dimer of trimers) interface [polypeptide binding]; other site 526225000678 trimer interface [polypeptide binding]; other site 526225000679 substrate binding site [chemical binding]; other site 526225000680 Mn binding site [ion binding]; other site 526225000681 arginine deiminase; Provisional; Region: PRK01388 526225000682 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 526225000683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225000684 NAD(P) binding site [chemical binding]; other site 526225000685 active site 526225000686 FAD binding domain; Region: FAD_binding_4; pfam01565 526225000687 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 526225000688 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 526225000689 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526225000690 Cysteine-rich domain; Region: CCG; pfam02754 526225000691 Cysteine-rich domain; Region: CCG; pfam02754 526225000692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225000693 S-adenosylmethionine binding site [chemical binding]; other site 526225000694 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 526225000695 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225000696 DNA binding residues [nucleotide binding] 526225000697 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 526225000698 Protein of unknown function (DUF664); Region: DUF664; pfam04978 526225000699 DinB superfamily; Region: DinB_2; pfam12867 526225000700 haloalkane dehalogenase; Provisional; Region: PRK03592 526225000701 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 526225000702 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 526225000703 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526225000704 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 526225000705 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225000706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225000707 Walker A/P-loop; other site 526225000708 ATP binding site [chemical binding]; other site 526225000709 Q-loop/lid; other site 526225000710 ABC transporter signature motif; other site 526225000711 Walker B; other site 526225000712 D-loop; other site 526225000713 H-loop/switch region; other site 526225000714 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 526225000715 Predicted membrane protein [Function unknown]; Region: COG2119 526225000716 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 526225000717 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 526225000718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225000719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225000720 Helix-turn-helix domain; Region: HTH_18; pfam12833 526225000721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225000722 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 526225000723 putative dimer interface [polypeptide binding]; other site 526225000724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225000725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225000726 metal binding site [ion binding]; metal-binding site 526225000727 active site 526225000728 I-site; other site 526225000729 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 526225000730 AIR carboxylase; Region: AIRC; cl00310 526225000731 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225000732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225000733 metal binding site [ion binding]; metal-binding site 526225000734 active site 526225000735 I-site; other site 526225000736 prephenate dehydratase; Provisional; Region: PRK11898 526225000737 Prephenate dehydratase; Region: PDT; pfam00800 526225000738 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 526225000739 putative L-Phe binding site [chemical binding]; other site 526225000740 MMPL family; Region: MMPL; pfam03176 526225000741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225000742 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 526225000743 oligomerisation interface [polypeptide binding]; other site 526225000744 mobile loop; other site 526225000745 roof hairpin; other site 526225000746 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 526225000747 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 526225000748 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225000749 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 526225000750 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225000751 phosphate binding site [ion binding]; other site 526225000752 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225000753 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 526225000754 DXD motif; other site 526225000755 HEAT repeats; Region: HEAT_2; pfam13646 526225000756 HEAT repeats; Region: HEAT_2; pfam13646 526225000757 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225000758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225000759 active site 526225000760 phosphorylation site [posttranslational modification] 526225000761 intermolecular recognition site; other site 526225000762 dimerization interface [polypeptide binding]; other site 526225000763 CHASE3 domain; Region: CHASE3; pfam05227 526225000764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225000765 phosphorylation site [posttranslational modification] 526225000766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225000767 ATP binding site [chemical binding]; other site 526225000768 Mg2+ binding site [ion binding]; other site 526225000769 G-X-G motif; other site 526225000770 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 526225000771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225000772 active site 526225000773 phosphorylation site [posttranslational modification] 526225000774 intermolecular recognition site; other site 526225000775 dimerization interface [polypeptide binding]; other site 526225000776 Response regulator receiver domain; Region: Response_reg; pfam00072 526225000777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225000778 active site 526225000779 phosphorylation site [posttranslational modification] 526225000780 intermolecular recognition site; other site 526225000781 dimerization interface [polypeptide binding]; other site 526225000782 seryl-tRNA synthetase; Provisional; Region: PRK05431 526225000783 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 526225000784 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 526225000785 dimer interface [polypeptide binding]; other site 526225000786 active site 526225000787 motif 1; other site 526225000788 motif 2; other site 526225000789 motif 3; other site 526225000790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 526225000791 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 526225000792 active site 526225000793 motif I; other site 526225000794 motif II; other site 526225000795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225000796 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 526225000797 active site 526225000798 motif I; other site 526225000799 motif II; other site 526225000800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225000801 motif II; other site 526225000802 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 526225000803 Domain of unknown function (DUF336); Region: DUF336; pfam03928 526225000804 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 526225000805 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 526225000806 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 526225000807 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 526225000808 alpha-beta subunit interface [polypeptide binding]; other site 526225000809 alpha-gamma subunit interface [polypeptide binding]; other site 526225000810 active site 526225000811 substrate and K+ binding site; other site 526225000812 K+ binding site [ion binding]; other site 526225000813 cobalamin binding site [chemical binding]; other site 526225000814 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 526225000815 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 526225000816 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 526225000817 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 526225000818 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526225000819 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526225000820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225000821 catalytic residue [active] 526225000822 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 526225000823 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 526225000824 NAD(P) binding site [chemical binding]; other site 526225000825 Cupin; Region: Cupin_6; pfam12852 526225000826 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 526225000827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225000828 4-coumarate--CoA ligase; Region: PLN02246 526225000829 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 526225000830 acyl-activating enzyme (AAE) consensus motif; other site 526225000831 active site 526225000832 putative CoA binding site [chemical binding]; other site 526225000833 AMP binding site [chemical binding]; other site 526225000834 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526225000835 CoenzymeA binding site [chemical binding]; other site 526225000836 subunit interaction site [polypeptide binding]; other site 526225000837 PHB binding site; other site 526225000838 dihydropteroate synthase; Region: DHPS; TIGR01496 526225000839 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 526225000840 substrate binding pocket [chemical binding]; other site 526225000841 dimer interface [polypeptide binding]; other site 526225000842 inhibitor binding site; inhibition site 526225000843 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 526225000844 putative active site [active] 526225000845 putative catalytic site [active] 526225000846 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225000847 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225000848 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 526225000849 IHF dimer interface [polypeptide binding]; other site 526225000850 IHF - DNA interface [nucleotide binding]; other site 526225000851 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225000852 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225000853 active site 526225000854 catalytic tetrad [active] 526225000855 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225000856 Predicted membrane protein [Function unknown]; Region: COG2860 526225000857 UPF0126 domain; Region: UPF0126; pfam03458 526225000858 amidase; Provisional; Region: PRK07235 526225000859 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 526225000860 acyl-coenzyme A oxidase; Region: PLN02636 526225000861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225000862 active site 526225000863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225000864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225000865 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 526225000866 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526225000867 dimer interface [polypeptide binding]; other site 526225000868 active site 526225000869 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 526225000870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225000871 NAD(P) binding site [chemical binding]; other site 526225000872 active site 526225000873 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 526225000874 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 526225000875 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 526225000876 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 526225000877 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526225000878 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526225000879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225000880 dimer interface [polypeptide binding]; other site 526225000881 conserved gate region; other site 526225000882 putative PBP binding loops; other site 526225000883 ABC-ATPase subunit interface; other site 526225000884 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526225000885 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 526225000886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225000887 putative PBP binding loops; other site 526225000888 dimer interface [polypeptide binding]; other site 526225000889 ABC-ATPase subunit interface; other site 526225000890 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 526225000891 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526225000892 Walker A/P-loop; other site 526225000893 ATP binding site [chemical binding]; other site 526225000894 Q-loop/lid; other site 526225000895 ABC transporter signature motif; other site 526225000896 Walker B; other site 526225000897 D-loop; other site 526225000898 H-loop/switch region; other site 526225000899 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 526225000900 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 526225000901 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526225000902 Walker A/P-loop; other site 526225000903 ATP binding site [chemical binding]; other site 526225000904 Q-loop/lid; other site 526225000905 ABC transporter signature motif; other site 526225000906 Walker B; other site 526225000907 D-loop; other site 526225000908 H-loop/switch region; other site 526225000909 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 526225000910 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 526225000911 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225000912 Methyltransferase domain; Region: Methyltransf_12; pfam08242 526225000913 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 526225000914 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 526225000915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 526225000916 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225000917 Ligand Binding Site [chemical binding]; other site 526225000918 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 526225000919 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 526225000920 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 526225000921 putative phosphate binding site [ion binding]; other site 526225000922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225000923 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 526225000924 substrate binding site [chemical binding]; other site 526225000925 oxyanion hole (OAH) forming residues; other site 526225000926 trimer interface [polypeptide binding]; other site 526225000927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225000928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225000929 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225000930 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225000931 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526225000932 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 526225000933 putative ADP-binding pocket [chemical binding]; other site 526225000934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225000935 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 526225000936 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 526225000937 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 526225000938 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 526225000939 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 526225000940 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526225000941 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 526225000942 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526225000943 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526225000944 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526225000945 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526225000946 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 526225000947 molybdopterin cofactor binding site; other site 526225000948 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 526225000949 4Fe-4S binding domain; Region: Fer4; cl02805 526225000950 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 526225000951 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 526225000952 classical (c) SDRs; Region: SDR_c; cd05233 526225000953 NAD(P) binding site [chemical binding]; other site 526225000954 active site 526225000955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225000956 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 526225000957 putative ADP-binding pocket [chemical binding]; other site 526225000958 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526225000959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225000960 active site 526225000961 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 526225000962 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 526225000963 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 526225000964 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225000965 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526225000966 Probable Catalytic site; other site 526225000967 metal-binding site 526225000968 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 526225000969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225000970 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 526225000971 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 526225000972 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 526225000973 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 526225000974 Chain length determinant protein; Region: Wzz; pfam02706 526225000975 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 526225000976 Phosphotransferase enzyme family; Region: APH; pfam01636 526225000977 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 526225000978 active site 526225000979 ATP binding site [chemical binding]; other site 526225000980 substrate binding site [chemical binding]; other site 526225000981 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 526225000982 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 526225000983 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 526225000984 active site 526225000985 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 526225000986 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225000987 Methyltransferase domain; Region: Methyltransf_12; pfam08242 526225000988 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 526225000989 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 526225000990 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 526225000991 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 526225000992 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 526225000993 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 526225000994 extended (e) SDRs; Region: SDR_e; cd08946 526225000995 NAD(P) binding site [chemical binding]; other site 526225000996 active site 526225000997 substrate binding site [chemical binding]; other site 526225000998 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526225000999 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 526225001000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001001 active site 526225001002 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 526225001003 putative ADP-binding pocket [chemical binding]; other site 526225001004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225001005 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 526225001006 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526225001007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001008 active site 526225001009 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 526225001010 Bacterial sugar transferase; Region: Bac_transf; pfam02397 526225001011 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526225001012 MULE transposase domain; Region: MULE; pfam10551 526225001013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225001014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225001015 NAD(P) binding site [chemical binding]; other site 526225001016 active site 526225001017 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 526225001018 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 526225001019 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 526225001020 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 526225001021 Predicted membrane protein [Function unknown]; Region: COG4763 526225001022 Acyltransferase family; Region: Acyl_transf_3; pfam01757 526225001023 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 526225001024 active site 526225001025 catalytic residues [active] 526225001026 Chain length determinant protein; Region: Wzz; cl15801 526225001027 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 526225001028 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526225001029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001030 active site 526225001031 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 526225001032 ABC-2 type transporter; Region: ABC2_membrane; cl17235 526225001033 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 526225001034 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 526225001035 Walker A/P-loop; other site 526225001036 ATP binding site [chemical binding]; other site 526225001037 Q-loop/lid; other site 526225001038 ABC transporter signature motif; other site 526225001039 Walker B; other site 526225001040 D-loop; other site 526225001041 H-loop/switch region; other site 526225001042 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 526225001043 putative carbohydrate binding site [chemical binding]; other site 526225001044 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 526225001045 active site 526225001046 Protein of unknown function (DUF563); Region: DUF563; pfam04577 526225001047 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225001048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001049 active site 526225001050 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526225001051 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 526225001052 active site 526225001053 active site 526225001054 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 526225001055 hypothetical protein; Provisional; Region: PRK07208 526225001056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225001057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225001058 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225001059 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 526225001060 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 526225001061 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 526225001062 putative ADP-binding pocket [chemical binding]; other site 526225001063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225001064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526225001065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001066 active site 526225001067 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 526225001068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526225001069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526225001070 active site 526225001071 Ribonuclease P; Region: Ribonuclease_P; cl00457 526225001072 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225001073 Methyltransferase domain; Region: Methyltransf_11; pfam08241 526225001074 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001076 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 526225001077 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 526225001078 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 526225001079 putative active site [active] 526225001080 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526225001081 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 526225001082 active site 526225001083 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 526225001084 putative ADP-binding pocket [chemical binding]; other site 526225001085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225001086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225001087 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 526225001088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001089 active site 526225001090 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 526225001091 Bacterial sugar transferase; Region: Bac_transf; pfam02397 526225001092 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 526225001093 Bacterial sugar transferase; Region: Bac_transf; pfam02397 526225001094 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 526225001095 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 526225001096 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 526225001097 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 526225001098 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 526225001099 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 526225001100 Transposase; Region: DEDD_Tnp_IS110; pfam01548 526225001101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 526225001102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 526225001103 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225001104 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526225001105 Probable Catalytic site; other site 526225001106 metal-binding site 526225001107 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526225001108 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 526225001109 Ligand binding site; other site 526225001110 Putative Catalytic site; other site 526225001111 DXD motif; other site 526225001112 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 526225001113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225001114 NAD(P) binding site [chemical binding]; other site 526225001115 active site 526225001116 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 526225001117 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 526225001118 AMP-binding enzyme; Region: AMP-binding; pfam00501 526225001119 acyl-activating enzyme (AAE) consensus motif; other site 526225001120 AMP binding site [chemical binding]; other site 526225001121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 526225001122 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225001123 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526225001124 active site 526225001125 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 526225001126 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 526225001127 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 526225001128 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225001129 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 526225001130 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 526225001131 putative active site [active] 526225001132 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526225001133 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 526225001134 active site 526225001135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001136 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 526225001137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225001138 acyl-activating enzyme (AAE) consensus motif; other site 526225001139 AMP binding site [chemical binding]; other site 526225001140 active site 526225001141 CoA binding site [chemical binding]; other site 526225001142 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 526225001143 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 526225001144 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 526225001145 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 526225001146 active site 526225001147 catalytic residues [active] 526225001148 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 526225001149 Ligand binding site; other site 526225001150 Putative Catalytic site; other site 526225001151 DXD motif; other site 526225001152 hypothetical protein; Provisional; Region: PRK07945 526225001153 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 526225001154 active site 526225001155 Predicted membrane protein [Function unknown]; Region: COG2259 526225001156 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 526225001157 active site 526225001158 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 526225001159 CGNR zinc finger; Region: zf-CGNR; pfam11706 526225001160 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225001161 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 526225001162 phosphate binding site [ion binding]; other site 526225001163 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225001164 MarR family; Region: MarR_2; pfam12802 526225001165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001166 active site 526225001167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225001168 active site 526225001169 motif I; other site 526225001170 motif II; other site 526225001171 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 526225001172 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 526225001173 putative active site [active] 526225001174 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 526225001175 putative ADP-binding pocket [chemical binding]; other site 526225001176 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 526225001177 dimer interface [polypeptide binding]; other site 526225001178 active site 526225001179 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 526225001180 ATP binding site [chemical binding]; other site 526225001181 substrate binding site [chemical binding]; other site 526225001182 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225001183 active site 526225001184 nucleotide binding site [chemical binding]; other site 526225001185 HIGH motif; other site 526225001186 KMSKS motif; other site 526225001187 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 526225001188 putative active site [active] 526225001189 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 526225001190 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526225001191 metal ion-dependent adhesion site (MIDAS); other site 526225001192 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225001193 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 526225001194 NAD binding site [chemical binding]; other site 526225001195 putative substrate binding site 2 [chemical binding]; other site 526225001196 putative substrate binding site 1 [chemical binding]; other site 526225001197 active site 526225001198 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 526225001199 prephenate dehydrogenase; Validated; Region: PRK08507 526225001200 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526225001201 CoenzymeA binding site [chemical binding]; other site 526225001202 subunit interaction site [polypeptide binding]; other site 526225001203 PHB binding site; other site 526225001204 Methyltransferase domain; Region: Methyltransf_31; pfam13847 526225001205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225001206 S-adenosylmethionine binding site [chemical binding]; other site 526225001207 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 526225001208 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 526225001209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225001210 motif II; other site 526225001211 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 526225001212 nucleoside/Zn binding site; other site 526225001213 dimer interface [polypeptide binding]; other site 526225001214 catalytic motif [active] 526225001215 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225001216 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225001217 active site 526225001218 ATP binding site [chemical binding]; other site 526225001219 substrate binding site [chemical binding]; other site 526225001220 activation loop (A-loop); other site 526225001221 EamA-like transporter family; Region: EamA; pfam00892 526225001222 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 526225001223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225001224 Walker A motif; other site 526225001225 ATP binding site [chemical binding]; other site 526225001226 Walker B motif; other site 526225001227 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 526225001228 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 526225001229 putative hydrophobic ligand binding site [chemical binding]; other site 526225001230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225001231 dimerization interface [polypeptide binding]; other site 526225001232 putative DNA binding site [nucleotide binding]; other site 526225001233 putative Zn2+ binding site [ion binding]; other site 526225001234 hypothetical protein; Validated; Region: PRK00153 526225001235 recombination protein RecR; Reviewed; Region: recR; PRK00076 526225001236 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 526225001237 RecR protein; Region: RecR; pfam02132 526225001238 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 526225001239 putative active site [active] 526225001240 putative metal-binding site [ion binding]; other site 526225001241 tetramer interface [polypeptide binding]; other site 526225001242 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 526225001243 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 526225001244 peptide binding site [polypeptide binding]; other site 526225001245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526225001246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225001247 dimer interface [polypeptide binding]; other site 526225001248 conserved gate region; other site 526225001249 putative PBP binding loops; other site 526225001250 ABC-ATPase subunit interface; other site 526225001251 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 526225001252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225001253 dimer interface [polypeptide binding]; other site 526225001254 conserved gate region; other site 526225001255 putative PBP binding loops; other site 526225001256 ABC-ATPase subunit interface; other site 526225001257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 526225001258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526225001259 Walker A/P-loop; other site 526225001260 ATP binding site [chemical binding]; other site 526225001261 Q-loop/lid; other site 526225001262 ABC transporter signature motif; other site 526225001263 Walker B; other site 526225001264 D-loop; other site 526225001265 H-loop/switch region; other site 526225001266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 526225001267 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 526225001268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526225001269 Walker A/P-loop; other site 526225001270 ATP binding site [chemical binding]; other site 526225001271 Q-loop/lid; other site 526225001272 ABC transporter signature motif; other site 526225001273 Walker B; other site 526225001274 D-loop; other site 526225001275 H-loop/switch region; other site 526225001276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 526225001277 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 526225001278 iron-sulfur cluster [ion binding]; other site 526225001279 [2Fe-2S] cluster binding site [ion binding]; other site 526225001280 Repair protein; Region: Repair_PSII; pfam04536 526225001281 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 526225001282 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225001283 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 526225001284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225001285 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 526225001286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225001287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225001288 metal binding site [ion binding]; metal-binding site 526225001289 active site 526225001290 I-site; other site 526225001291 Pirin; Region: Pirin; pfam02678 526225001292 Pirin-related protein [General function prediction only]; Region: COG1741 526225001293 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 526225001294 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 526225001295 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526225001296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526225001297 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526225001298 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526225001299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225001300 ABC transporter; Region: ABC_tran_2; pfam12848 526225001301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225001302 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 526225001303 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225001304 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 526225001305 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 526225001306 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 526225001307 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 526225001308 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225001309 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 526225001310 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 526225001311 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 526225001312 putative dimer interface [polypeptide binding]; other site 526225001313 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526225001314 2-isopropylmalate synthase; Validated; Region: PRK03739 526225001315 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 526225001316 active site 526225001317 catalytic residues [active] 526225001318 metal binding site [ion binding]; metal-binding site 526225001319 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 526225001320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225001321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225001322 non-specific DNA binding site [nucleotide binding]; other site 526225001323 salt bridge; other site 526225001324 sequence-specific DNA binding site [nucleotide binding]; other site 526225001325 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 526225001326 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 526225001327 putative active site [active] 526225001328 catalytic site [active] 526225001329 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 526225001330 putative active site [active] 526225001331 catalytic site [active] 526225001332 aspartate kinase; Reviewed; Region: PRK06635 526225001333 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 526225001334 putative nucleotide binding site [chemical binding]; other site 526225001335 putative catalytic residues [active] 526225001336 putative Mg ion binding site [ion binding]; other site 526225001337 putative aspartate binding site [chemical binding]; other site 526225001338 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 526225001339 putative allosteric regulatory site; other site 526225001340 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 526225001341 putative allosteric regulatory residue; other site 526225001342 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 526225001343 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 526225001344 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 526225001345 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225001346 Domain of unknown function DUF21; Region: DUF21; pfam01595 526225001347 FOG: CBS domain [General function prediction only]; Region: COG0517 526225001348 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 526225001349 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 526225001350 Domain of unknown function DUF21; Region: DUF21; pfam01595 526225001351 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 526225001352 Transporter associated domain; Region: CorC_HlyC; smart01091 526225001353 phosphodiesterase YaeI; Provisional; Region: PRK11340 526225001354 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 526225001355 putative active site [active] 526225001356 putative metal binding site [ion binding]; other site 526225001357 Yqey-like protein; Region: YqeY; cl17540 526225001358 Transglycosylase; Region: Transgly; pfam00912 526225001359 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 526225001360 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 526225001361 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 526225001362 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 526225001363 P loop; other site 526225001364 Nucleotide binding site [chemical binding]; other site 526225001365 DTAP/Switch II; other site 526225001366 Switch I; other site 526225001367 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 526225001368 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 526225001369 DTAP/Switch II; other site 526225001370 Switch I; other site 526225001371 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 526225001372 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 526225001373 homotrimer interaction site [polypeptide binding]; other site 526225001374 putative active site [active] 526225001375 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526225001376 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526225001377 ligand binding site [chemical binding]; other site 526225001378 flexible hinge region; other site 526225001379 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 526225001380 non-specific DNA interactions [nucleotide binding]; other site 526225001381 DNA binding site [nucleotide binding] 526225001382 sequence specific DNA binding site [nucleotide binding]; other site 526225001383 putative cAMP binding site [chemical binding]; other site 526225001384 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 526225001385 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526225001386 minor groove reading motif; other site 526225001387 helix-hairpin-helix signature motif; other site 526225001388 substrate binding pocket [chemical binding]; other site 526225001389 active site 526225001390 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526225001391 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526225001392 catalytic residues [active] 526225001393 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 526225001394 putative active site [active] 526225001395 putative CoA binding site [chemical binding]; other site 526225001396 nudix motif; other site 526225001397 metal binding site [ion binding]; metal-binding site 526225001398 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 526225001399 Colicin V production protein; Region: Colicin_V; pfam02674 526225001400 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 526225001401 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526225001402 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225001403 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 526225001404 acetyl-CoA synthetase; Provisional; Region: PRK00174 526225001405 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 526225001406 active site 526225001407 CoA binding site [chemical binding]; other site 526225001408 acyl-activating enzyme (AAE) consensus motif; other site 526225001409 AMP binding site [chemical binding]; other site 526225001410 acetate binding site [chemical binding]; other site 526225001411 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 526225001412 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 526225001413 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 526225001414 HflX GTPase family; Region: HflX; cd01878 526225001415 G1 box; other site 526225001416 GTP/Mg2+ binding site [chemical binding]; other site 526225001417 Switch I region; other site 526225001418 G2 box; other site 526225001419 G3 box; other site 526225001420 Switch II region; other site 526225001421 G4 box; other site 526225001422 G5 box; other site 526225001423 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 526225001424 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 526225001425 short chain dehydrogenase; Provisional; Region: PRK08263 526225001426 classical (c) SDRs; Region: SDR_c; cd05233 526225001427 NAD(P) binding site [chemical binding]; other site 526225001428 active site 526225001429 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 526225001430 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 526225001431 DNA binding residues [nucleotide binding] 526225001432 dimer interface [polypeptide binding]; other site 526225001433 [2Fe-2S] cluster binding site [ion binding]; other site 526225001434 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 526225001435 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 526225001436 putative active site [active] 526225001437 metal binding site [ion binding]; metal-binding site 526225001438 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225001439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225001440 non-specific DNA binding site [nucleotide binding]; other site 526225001441 salt bridge; other site 526225001442 sequence-specific DNA binding site [nucleotide binding]; other site 526225001443 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 526225001444 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 526225001445 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 526225001446 homodimer interface [polypeptide binding]; other site 526225001447 active site 526225001448 SAM binding site [chemical binding]; other site 526225001449 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 526225001450 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 526225001451 putative dimer interface [polypeptide binding]; other site 526225001452 active site pocket [active] 526225001453 hypothetical protein; Provisional; Region: PRK07908 526225001454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526225001455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225001456 homodimer interface [polypeptide binding]; other site 526225001457 catalytic residue [active] 526225001458 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 526225001459 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 526225001460 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 526225001461 Walker A/P-loop; other site 526225001462 ATP binding site [chemical binding]; other site 526225001463 Q-loop/lid; other site 526225001464 ABC transporter signature motif; other site 526225001465 Walker B; other site 526225001466 D-loop; other site 526225001467 H-loop/switch region; other site 526225001468 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 526225001469 cobalt transport protein CbiN; Provisional; Region: PRK02898 526225001470 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 526225001471 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 526225001472 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 526225001473 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 526225001474 catalytic triad [active] 526225001475 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 526225001476 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 526225001477 homodimer interface [polypeptide binding]; other site 526225001478 Walker A motif; other site 526225001479 ATP binding site [chemical binding]; other site 526225001480 hydroxycobalamin binding site [chemical binding]; other site 526225001481 Walker B motif; other site 526225001482 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 526225001483 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 526225001484 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 526225001485 metal ion-dependent adhesion site (MIDAS); other site 526225001486 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225001487 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 526225001488 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 526225001489 Putative ammonia monooxygenase; Region: AmoA; pfam05145 526225001490 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 526225001491 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225001492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225001493 S-adenosylmethionine binding site [chemical binding]; other site 526225001494 PemK-like protein; Region: PemK; pfam02452 526225001495 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 526225001496 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 526225001497 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526225001498 active site 526225001499 cobyric acid synthase; Provisional; Region: PRK00784 526225001500 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 526225001501 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 526225001502 catalytic triad [active] 526225001503 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 526225001504 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 526225001505 putative acyl-acceptor binding pocket; other site 526225001506 PAS fold; Region: PAS_3; pfam08447 526225001507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 526225001508 putative active site [active] 526225001509 heme pocket [chemical binding]; other site 526225001510 ANTAR domain; Region: ANTAR; pfam03861 526225001511 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 526225001512 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 526225001513 active site 526225001514 catalytic residues [active] 526225001515 metal binding site [ion binding]; metal-binding site 526225001516 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 526225001517 active site 526225001518 putative homodimer interface [polypeptide binding]; other site 526225001519 SAM binding site [chemical binding]; other site 526225001520 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 526225001521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 526225001522 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 526225001523 SAM binding site [chemical binding]; other site 526225001524 active site 526225001525 homodimer interface [polypeptide binding]; other site 526225001526 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 526225001527 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 526225001528 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 526225001529 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 526225001530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225001531 motif II; other site 526225001532 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 526225001533 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 526225001534 conserved cys residue [active] 526225001535 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225001536 MarR family; Region: MarR_2; pfam12802 526225001537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225001538 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 526225001539 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225001540 phosphate binding site [ion binding]; other site 526225001541 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 526225001542 active site 526225001543 SAM binding site [chemical binding]; other site 526225001544 homodimer interface [polypeptide binding]; other site 526225001545 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 526225001546 active site 526225001547 SAM binding site [chemical binding]; other site 526225001548 homodimer interface [polypeptide binding]; other site 526225001549 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 526225001550 Precorrin-8X methylmutase; Region: CbiC; pfam02570 526225001551 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 526225001552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225001553 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225001554 sequence-specific DNA binding site [nucleotide binding]; other site 526225001555 salt bridge; other site 526225001556 TIGR04222 domain; Region: near_uncomplex 526225001557 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 526225001558 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 526225001559 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 526225001560 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 526225001561 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 526225001562 homotrimer interface [polypeptide binding]; other site 526225001563 Walker A motif; other site 526225001564 GTP binding site [chemical binding]; other site 526225001565 Walker B motif; other site 526225001566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225001567 catalytic core [active] 526225001568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225001569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225001570 active site 526225001571 catalytic tetrad [active] 526225001572 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 526225001573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225001574 motif II; other site 526225001575 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 526225001576 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526225001577 Type II/IV secretion system protein; Region: T2SE; pfam00437 526225001578 Walker A motif; other site 526225001579 ATP binding site [chemical binding]; other site 526225001580 Walker B motif; other site 526225001581 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 526225001582 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 526225001583 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 526225001584 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 526225001585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225001586 ATP binding site [chemical binding]; other site 526225001587 putative Mg++ binding site [ion binding]; other site 526225001588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225001589 ATP-binding site [chemical binding]; other site 526225001590 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 526225001591 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 526225001592 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 526225001593 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 526225001594 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 526225001595 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 526225001596 active site 526225001597 interdomain interaction site; other site 526225001598 putative metal-binding site [ion binding]; other site 526225001599 nucleotide binding site [chemical binding]; other site 526225001600 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 526225001601 domain I; other site 526225001602 phosphate binding site [ion binding]; other site 526225001603 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 526225001604 domain II; other site 526225001605 domain III; other site 526225001606 nucleotide binding site [chemical binding]; other site 526225001607 DNA binding groove [nucleotide binding] 526225001608 catalytic site [active] 526225001609 domain IV; other site 526225001610 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 526225001611 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 526225001612 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 526225001613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225001614 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 526225001615 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 526225001616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225001617 S-adenosylmethionine binding site [chemical binding]; other site 526225001618 thymidylate kinase; Validated; Region: tmk; PRK00698 526225001619 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 526225001620 TMP-binding site; other site 526225001621 ATP-binding site [chemical binding]; other site 526225001622 DNA polymerase III subunit delta'; Validated; Region: PRK07940 526225001623 DNA polymerase III subunit delta'; Validated; Region: PRK08485 526225001624 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 526225001625 dimer interface [polypeptide binding]; other site 526225001626 substrate binding site [chemical binding]; other site 526225001627 metal binding sites [ion binding]; metal-binding site 526225001628 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 526225001629 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 526225001630 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 526225001631 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 526225001632 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 526225001633 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 526225001634 Ligand Binding Site [chemical binding]; other site 526225001635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526225001636 active site 526225001637 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 526225001638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225001639 Walker A motif; other site 526225001640 ATP binding site [chemical binding]; other site 526225001641 Walker B motif; other site 526225001642 arginine finger; other site 526225001643 Peptidase family M41; Region: Peptidase_M41; pfam01434 526225001644 GTP cyclohydrolase I; Provisional; Region: PLN03044 526225001645 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 526225001646 homodecamer interface [polypeptide binding]; other site 526225001647 active site 526225001648 putative catalytic site residues [active] 526225001649 zinc binding site [ion binding]; other site 526225001650 GTP-CH-I/GFRP interaction surface; other site 526225001651 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 526225001652 substrate binding pocket [chemical binding]; other site 526225001653 inhibitor binding site; inhibition site 526225001654 Dihydroneopterin aldolase; Region: FolB; pfam02152 526225001655 active site 526225001656 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 526225001657 catalytic center binding site [active] 526225001658 ATP binding site [chemical binding]; other site 526225001659 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 526225001660 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 526225001661 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 526225001662 Walker A/P-loop; other site 526225001663 ATP binding site [chemical binding]; other site 526225001664 Q-loop/lid; other site 526225001665 ABC transporter signature motif; other site 526225001666 Walker B; other site 526225001667 D-loop; other site 526225001668 H-loop/switch region; other site 526225001669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225001670 dimer interface [polypeptide binding]; other site 526225001671 conserved gate region; other site 526225001672 ABC-ATPase subunit interface; other site 526225001673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225001674 ABC-ATPase subunit interface; other site 526225001675 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 526225001676 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 526225001677 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 526225001678 Rossmann-like domain; Region: Rossmann-like; pfam10727 526225001679 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 526225001680 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 526225001681 active site 526225001682 nucleotide binding site [chemical binding]; other site 526225001683 HIGH motif; other site 526225001684 KMSKS motif; other site 526225001685 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 526225001686 tetramerization interface [polypeptide binding]; other site 526225001687 active site 526225001688 L-aspartate oxidase; Provisional; Region: PRK07804 526225001689 L-aspartate oxidase; Provisional; Region: PRK06175 526225001690 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 526225001691 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 526225001692 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 526225001693 dimerization interface [polypeptide binding]; other site 526225001694 active site 526225001695 Type III pantothenate kinase; Region: Pan_kinase; cl17198 526225001696 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 526225001697 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 526225001698 dimer interface [polypeptide binding]; other site 526225001699 putative anticodon binding site; other site 526225001700 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526225001701 motif 1; other site 526225001702 dimer interface [polypeptide binding]; other site 526225001703 active site 526225001704 motif 2; other site 526225001705 motif 3; other site 526225001706 Lsr2; Region: Lsr2; pfam11774 526225001707 Clp protease ATP binding subunit; Region: clpC; CHL00095 526225001708 Clp amino terminal domain; Region: Clp_N; pfam02861 526225001709 Clp amino terminal domain; Region: Clp_N; pfam02861 526225001710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225001711 Walker A motif; other site 526225001712 ATP binding site [chemical binding]; other site 526225001713 Walker B motif; other site 526225001714 arginine finger; other site 526225001715 UvrB/uvrC motif; Region: UVR; pfam02151 526225001716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225001717 Walker A motif; other site 526225001718 ATP binding site [chemical binding]; other site 526225001719 Walker B motif; other site 526225001720 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 526225001721 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 526225001722 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526225001723 minor groove reading motif; other site 526225001724 helix-hairpin-helix signature motif; other site 526225001725 active site 526225001726 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 526225001727 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 526225001728 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 526225001729 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 526225001730 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 526225001731 DNA repair protein RadA; Provisional; Region: PRK11823 526225001732 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526225001733 Walker A motif; other site 526225001734 ATP binding site [chemical binding]; other site 526225001735 Walker B motif; other site 526225001736 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 526225001737 Protein of unknown function (DUF461); Region: DUF461; cl01071 526225001738 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 526225001739 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 526225001740 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 526225001741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225001742 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225001743 DNA binding residues [nucleotide binding] 526225001744 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 526225001745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225001746 active site 526225001747 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 526225001748 homotrimer interaction site [polypeptide binding]; other site 526225001749 zinc binding site [ion binding]; other site 526225001750 CDP-binding sites; other site 526225001751 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 526225001752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225001753 active site 526225001754 HIGH motif; other site 526225001755 nucleotide binding site [chemical binding]; other site 526225001756 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 526225001757 KMSKS motif; other site 526225001758 tRNA binding surface [nucleotide binding]; other site 526225001759 anticodon binding site; other site 526225001760 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 526225001761 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 526225001762 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 526225001763 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 526225001764 Protein of unknown function (DUF445); Region: DUF445; pfam04286 526225001765 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526225001766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526225001767 protein binding site [polypeptide binding]; other site 526225001768 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 526225001769 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225001770 Ligand Binding Site [chemical binding]; other site 526225001771 Lysine efflux permease [General function prediction only]; Region: COG1279 526225001772 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 526225001773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526225001774 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526225001775 dimerization interface [polypeptide binding]; other site 526225001776 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225001777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225001778 non-specific DNA binding site [nucleotide binding]; other site 526225001779 salt bridge; other site 526225001780 sequence-specific DNA binding site [nucleotide binding]; other site 526225001781 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 526225001782 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 526225001783 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526225001784 Walker A motif; other site 526225001785 ATP binding site [chemical binding]; other site 526225001786 Walker B motif; other site 526225001787 TadE-like protein; Region: TadE; pfam07811 526225001788 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526225001789 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526225001790 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 526225001791 Abi-like protein; Region: Abi_2; pfam07751 526225001792 AAA-like domain; Region: AAA_10; pfam12846 526225001793 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526225001794 Peptidase family M23; Region: Peptidase_M23; pfam01551 526225001795 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 526225001796 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 526225001797 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 526225001798 Helix-turn-helix domain; Region: HTH_38; pfam13936 526225001799 Homeodomain-like domain; Region: HTH_32; pfam13565 526225001800 Integrase core domain; Region: rve; pfam00665 526225001801 DDE superfamily endonuclease; Region: DDE_4; pfam13359 526225001802 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 526225001803 Transglycosylase; Region: Transgly; pfam00912 526225001804 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 526225001805 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 526225001806 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 526225001807 putative active site [active] 526225001808 putative metal binding site [ion binding]; other site 526225001809 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 526225001810 Tetratricopeptide repeat; Region: TPR_10; cl17452 526225001811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225001812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225001813 active site 526225001814 phosphorylation site [posttranslational modification] 526225001815 intermolecular recognition site; other site 526225001816 dimerization interface [polypeptide binding]; other site 526225001817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225001818 DNA binding residues [nucleotide binding] 526225001819 dimerization interface [polypeptide binding]; other site 526225001820 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 526225001821 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 526225001822 Lsr2; Region: Lsr2; pfam11774 526225001823 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 526225001824 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 526225001825 Lsr2; Region: Lsr2; pfam11774 526225001826 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225001827 active site 526225001828 Predicted transcriptional regulator [Transcription]; Region: COG4742 526225001829 Fic/DOC family; Region: Fic; cl00960 526225001830 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526225001831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225001832 NAD(P) binding site [chemical binding]; other site 526225001833 active site 526225001834 TIR domain; Region: TIR_2; pfam13676 526225001835 TIR domain; Region: TIR_2; pfam13676 526225001836 TIR domain; Region: TIR_2; pfam13676 526225001837 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 526225001838 TrwC relaxase; Region: TrwC; pfam08751 526225001839 AAA domain; Region: AAA_30; pfam13604 526225001840 Family description; Region: UvrD_C_2; pfam13538 526225001841 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 526225001842 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 526225001843 active site 526225001844 metal binding site [ion binding]; metal-binding site 526225001845 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 526225001846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225001847 ATP binding site [chemical binding]; other site 526225001848 Mg2+ binding site [ion binding]; other site 526225001849 G-X-G motif; other site 526225001850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225001851 DNA binding residues [nucleotide binding] 526225001852 AIPR protein; Region: AIPR; pfam10592 526225001853 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 526225001854 Z1 domain; Region: Z1; pfam10593 526225001855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225001856 ATP binding site [chemical binding]; other site 526225001857 Mg2+ binding site [ion binding]; other site 526225001858 G-X-G motif; other site 526225001859 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 526225001860 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 526225001861 cofactor binding site; other site 526225001862 DNA binding site [nucleotide binding] 526225001863 substrate interaction site [chemical binding]; other site 526225001864 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 526225001865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225001866 ATP binding site [chemical binding]; other site 526225001867 Mg2+ binding site [ion binding]; other site 526225001868 G-X-G motif; other site 526225001869 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 526225001870 additional DNA contacts [nucleotide binding]; other site 526225001871 mismatch recognition site; other site 526225001872 active site 526225001873 zinc binding site [ion binding]; other site 526225001874 DNA intercalation site [nucleotide binding]; other site 526225001875 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225001876 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225001877 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225001878 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225001879 active site 526225001880 DNA binding site [nucleotide binding] 526225001881 Int/Topo IB signature motif; other site 526225001882 HAMP domain; Region: HAMP; pfam00672 526225001883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225001884 dimerization interface [polypeptide binding]; other site 526225001885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225001886 dimer interface [polypeptide binding]; other site 526225001887 phosphorylation site [posttranslational modification] 526225001888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225001889 ATP binding site [chemical binding]; other site 526225001890 Mg2+ binding site [ion binding]; other site 526225001891 G-X-G motif; other site 526225001892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225001893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225001894 active site 526225001895 phosphorylation site [posttranslational modification] 526225001896 intermolecular recognition site; other site 526225001897 dimerization interface [polypeptide binding]; other site 526225001898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225001899 DNA binding site [nucleotide binding] 526225001900 Dodecin; Region: Dodecin; pfam07311 526225001901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 526225001902 FOG: CBS domain [General function prediction only]; Region: COG0517 526225001903 Predicted permeases [General function prediction only]; Region: RarD; COG2962 526225001904 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 526225001905 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 526225001906 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225001907 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526225001908 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 526225001909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225001910 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 526225001911 Walker A/P-loop; other site 526225001912 ATP binding site [chemical binding]; other site 526225001913 Q-loop/lid; other site 526225001914 ABC transporter signature motif; other site 526225001915 Walker B; other site 526225001916 D-loop; other site 526225001917 H-loop/switch region; other site 526225001918 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 526225001919 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 526225001920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225001921 active site 526225001922 motif I; other site 526225001923 motif II; other site 526225001924 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 526225001925 threonine synthase; Validated; Region: PRK07591 526225001926 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 526225001927 homodimer interface [polypeptide binding]; other site 526225001928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225001929 catalytic residue [active] 526225001930 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526225001931 DNA-binding site [nucleotide binding]; DNA binding site 526225001932 RNA-binding motif; other site 526225001933 classical (c) SDRs; Region: SDR_c; cd05233 526225001934 NAD(P) binding site [chemical binding]; other site 526225001935 active site 526225001936 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 526225001937 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 526225001938 ring oligomerisation interface [polypeptide binding]; other site 526225001939 ATP/Mg binding site [chemical binding]; other site 526225001940 stacking interactions; other site 526225001941 hinge regions; other site 526225001942 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 526225001943 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 526225001944 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 526225001945 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 526225001946 Interdomain contacts; other site 526225001947 Protein of unknown function DUF72; Region: DUF72; pfam01904 526225001948 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225001949 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225001950 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526225001951 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 526225001952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 526225001953 acetylornithine deacetylase; Validated; Region: PRK06915 526225001954 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526225001955 metal binding site [ion binding]; metal-binding site 526225001956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225001957 metabolite-proton symporter; Region: 2A0106; TIGR00883 526225001958 putative substrate translocation pore; other site 526225001959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225001960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225001961 DNA binding residues [nucleotide binding] 526225001962 dimerization interface [polypeptide binding]; other site 526225001963 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 526225001964 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 526225001965 ATP binding site [chemical binding]; other site 526225001966 putative Mg++ binding site [ion binding]; other site 526225001967 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526225001968 putative active site [active] 526225001969 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 526225001970 Predicted ATPase [General function prediction only]; Region: COG3903 526225001971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225001972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225001973 DNA binding residues [nucleotide binding] 526225001974 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 526225001975 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 526225001976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225001977 ATP binding site [chemical binding]; other site 526225001978 putative Mg++ binding site [ion binding]; other site 526225001979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225001980 nucleotide binding region [chemical binding]; other site 526225001981 ATP-binding site [chemical binding]; other site 526225001982 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 526225001983 WYL domain; Region: WYL; pfam13280 526225001984 AMP-binding domain protein; Validated; Region: PRK08315 526225001985 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225001986 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 526225001987 acyl-activating enzyme (AAE) consensus motif; other site 526225001988 acyl-activating enzyme (AAE) consensus motif; other site 526225001989 putative AMP binding site [chemical binding]; other site 526225001990 putative active site [active] 526225001991 putative CoA binding site [chemical binding]; other site 526225001992 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 526225001993 putative catalytic site [active] 526225001994 putative metal binding site [ion binding]; other site 526225001995 putative phosphate binding site [ion binding]; other site 526225001996 Domain of unknown function (DUF202); Region: DUF202; cl09954 526225001997 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526225001998 DNA-binding site [nucleotide binding]; DNA binding site 526225001999 RNA-binding motif; other site 526225002000 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 526225002001 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 526225002002 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225002003 MarR family; Region: MarR; pfam01047 526225002004 H+ Antiporter protein; Region: 2A0121; TIGR00900 526225002005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225002006 putative substrate translocation pore; other site 526225002007 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 526225002008 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 526225002009 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 526225002010 putative heme binding site [chemical binding]; other site 526225002011 putative substrate binding site [chemical binding]; other site 526225002012 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225002013 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225002014 active site 526225002015 catalytic tetrad [active] 526225002016 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 526225002017 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 526225002018 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225002019 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 526225002020 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 526225002021 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 526225002022 phosphoserine aminotransferase; Provisional; Region: PRK03080 526225002023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225002024 catalytic residue [active] 526225002025 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 526225002026 dimer interface [polypeptide binding]; other site 526225002027 Citrate synthase; Region: Citrate_synt; pfam00285 526225002028 active site 526225002029 citrylCoA binding site [chemical binding]; other site 526225002030 oxalacetate/citrate binding site [chemical binding]; other site 526225002031 coenzyme A binding site [chemical binding]; other site 526225002032 catalytic triad [active] 526225002033 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 526225002034 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 526225002035 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 526225002036 H+ Antiporter protein; Region: 2A0121; TIGR00900 526225002037 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 526225002038 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 526225002039 Fe-S cluster binding site [ion binding]; other site 526225002040 active site 526225002041 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 526225002042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225002043 Walker A/P-loop; other site 526225002044 ATP binding site [chemical binding]; other site 526225002045 Q-loop/lid; other site 526225002046 ABC transporter signature motif; other site 526225002047 Walker B; other site 526225002048 D-loop; other site 526225002049 H-loop/switch region; other site 526225002050 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 526225002051 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 526225002052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526225002053 binding surface 526225002054 TPR motif; other site 526225002055 TPR repeat; Region: TPR_11; pfam13414 526225002056 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 526225002057 active site 526225002058 catalytic site [active] 526225002059 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 526225002060 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 526225002061 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 526225002062 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 526225002063 active site 526225002064 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 526225002065 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 526225002066 ferredoxin-NADP+ reductase; Region: PLN02852 526225002067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225002068 Uncharacterized conserved protein [Function unknown]; Region: COG1359 526225002069 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 526225002070 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 526225002071 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 526225002072 putative DNA binding site [nucleotide binding]; other site 526225002073 catalytic residue [active] 526225002074 putative H2TH interface [polypeptide binding]; other site 526225002075 putative catalytic residues [active] 526225002076 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 526225002077 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 526225002078 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 526225002079 DNA photolyase; Region: DNA_photolyase; pfam00875 526225002080 Predicted acetyltransferase [General function prediction only]; Region: COG2388 526225002081 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 526225002082 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225002083 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 526225002084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225002085 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 526225002086 DNA binding site [nucleotide binding] 526225002087 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 526225002088 NB-ARC domain; Region: NB-ARC; pfam00931 526225002089 AAA domain; Region: AAA_30; pfam13604 526225002090 Family description; Region: UvrD_C_2; pfam13538 526225002091 Helix-turn-helix domain; Region: HTH_17; pfam12728 526225002092 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225002093 active site 526225002094 DNA binding site [nucleotide binding] 526225002095 Int/Topo IB signature motif; other site 526225002096 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225002097 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 526225002098 Na binding site [ion binding]; other site 526225002099 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 526225002100 nucleoside/Zn binding site; other site 526225002101 dimer interface [polypeptide binding]; other site 526225002102 catalytic motif [active] 526225002103 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 526225002104 hydrophobic ligand binding site; other site 526225002105 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 526225002106 NAD-dependent deacetylase; Provisional; Region: PRK00481 526225002107 Phosphotransferase enzyme family; Region: APH; pfam01636 526225002108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 526225002109 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526225002110 CoenzymeA binding site [chemical binding]; other site 526225002111 subunit interaction site [polypeptide binding]; other site 526225002112 PHB binding site; other site 526225002113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225002114 active site 526225002115 metal binding site [ion binding]; metal-binding site 526225002116 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 526225002117 putative deacylase active site [active] 526225002118 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 526225002119 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 526225002120 SnoaL-like domain; Region: SnoaL_2; pfam12680 526225002121 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225002122 MarR family; Region: MarR_2; pfam12802 526225002123 MarR family; Region: MarR_2; cl17246 526225002124 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 526225002125 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 526225002126 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 526225002127 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 526225002128 CoA-transferase family III; Region: CoA_transf_3; pfam02515 526225002129 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 526225002130 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 526225002131 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 526225002132 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 526225002133 active site 526225002134 tetramer interface; other site 526225002135 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 526225002136 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 526225002137 dimer interface [polypeptide binding]; other site 526225002138 putative functional site; other site 526225002139 putative MPT binding site; other site 526225002140 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 526225002141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526225002142 PRC-barrel domain; Region: PRC; pfam05239 526225002143 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 526225002144 Catalytic site [active] 526225002145 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225002146 metal binding site [ion binding]; metal-binding site 526225002147 active site 526225002148 I-site; other site 526225002149 enoyl-CoA hydratase; Provisional; Region: PRK06688 526225002150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225002151 substrate binding site [chemical binding]; other site 526225002152 oxyanion hole (OAH) forming residues; other site 526225002153 trimer interface [polypeptide binding]; other site 526225002154 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 526225002155 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 526225002156 Predicted methyltransferases [General function prediction only]; Region: COG0313 526225002157 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 526225002158 putative SAM binding site [chemical binding]; other site 526225002159 putative homodimer interface [polypeptide binding]; other site 526225002160 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 526225002161 putative active site [active] 526225002162 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 526225002163 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 526225002164 oligomer interface [polypeptide binding]; other site 526225002165 metal binding site [ion binding]; metal-binding site 526225002166 metal binding site [ion binding]; metal-binding site 526225002167 putative Cl binding site [ion binding]; other site 526225002168 basic sphincter; other site 526225002169 hydrophobic gate; other site 526225002170 periplasmic entrance; other site 526225002171 amino acid transporter; Region: 2A0306; TIGR00909 526225002172 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 526225002173 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 526225002174 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 526225002175 active site 526225002176 HIGH motif; other site 526225002177 KMSKS motif; other site 526225002178 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 526225002179 tRNA binding surface [nucleotide binding]; other site 526225002180 anticodon binding site; other site 526225002181 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 526225002182 active site 526225002183 Domain of unknown function (DUF348); Region: DUF348; pfam03990 526225002184 Domain of unknown function (DUF348); Region: DUF348; pfam03990 526225002185 G5 domain; Region: G5; pfam07501 526225002186 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 526225002187 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 526225002188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225002189 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 526225002190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225002191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225002192 Fatty acid desaturase; Region: FA_desaturase; pfam00487 526225002193 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 526225002194 Di-iron ligands [ion binding]; other site 526225002195 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 526225002196 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 526225002197 Substrate binding site; other site 526225002198 Mg++ binding site; other site 526225002199 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 526225002200 active site 526225002201 substrate binding site [chemical binding]; other site 526225002202 CoA binding site [chemical binding]; other site 526225002203 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 526225002204 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 526225002205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526225002206 active site 526225002207 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 526225002208 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 526225002209 NAD(P) binding site [chemical binding]; other site 526225002210 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 526225002211 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 526225002212 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 526225002213 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 526225002214 5S rRNA interface [nucleotide binding]; other site 526225002215 CTC domain interface [polypeptide binding]; other site 526225002216 L16 interface [polypeptide binding]; other site 526225002217 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 526225002218 putative active site [active] 526225002219 catalytic residue [active] 526225002220 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 526225002221 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 526225002222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225002223 ATP binding site [chemical binding]; other site 526225002224 putative Mg++ binding site [ion binding]; other site 526225002225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225002226 nucleotide binding region [chemical binding]; other site 526225002227 ATP-binding site [chemical binding]; other site 526225002228 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 526225002229 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 526225002230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225002231 acyl-activating enzyme (AAE) consensus motif; other site 526225002232 AMP binding site [chemical binding]; other site 526225002233 active site 526225002234 CoA binding site [chemical binding]; other site 526225002235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 526225002236 Thioesterase domain; Region: Thioesterase; pfam00975 526225002237 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 526225002238 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 526225002239 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 526225002240 homodimer interface [polypeptide binding]; other site 526225002241 metal binding site [ion binding]; metal-binding site 526225002242 enolase; Provisional; Region: eno; PRK00077 526225002243 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 526225002244 dimer interface [polypeptide binding]; other site 526225002245 metal binding site [ion binding]; metal-binding site 526225002246 substrate binding pocket [chemical binding]; other site 526225002247 Protein of unknown function (DUF501); Region: DUF501; cl00652 526225002248 exopolyphosphatase; Region: exo_poly_only; TIGR03706 526225002249 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 526225002250 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 526225002251 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 526225002252 Fe-S cluster binding site [ion binding]; other site 526225002253 DNA binding site [nucleotide binding] 526225002254 active site 526225002255 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 526225002256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225002257 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526225002258 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 526225002259 PA/protease or protease-like domain interface [polypeptide binding]; other site 526225002260 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 526225002261 Peptidase family M28; Region: Peptidase_M28; pfam04389 526225002262 active site 526225002263 metal binding site [ion binding]; metal-binding site 526225002264 Bax inhibitor 1 like; Region: BaxI_1; cl17691 526225002265 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 526225002266 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526225002267 dimer interface [polypeptide binding]; other site 526225002268 active site 526225002269 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 526225002270 active site 526225002271 catalytic triad [active] 526225002272 oxyanion hole [active] 526225002273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 526225002274 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 526225002275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526225002276 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 526225002277 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526225002278 metal ion-dependent adhesion site (MIDAS); other site 526225002279 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 526225002280 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 526225002281 threonine dehydratase; Provisional; Region: PRK08198 526225002282 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 526225002283 tetramer interface [polypeptide binding]; other site 526225002284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225002285 catalytic residue [active] 526225002286 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 526225002287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225002288 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 526225002289 Walker A/P-loop; other site 526225002290 ATP binding site [chemical binding]; other site 526225002291 Q-loop/lid; other site 526225002292 ABC transporter signature motif; other site 526225002293 Walker B; other site 526225002294 D-loop; other site 526225002295 H-loop/switch region; other site 526225002296 ABC-2 type transporter; Region: ABC2_membrane; cl17235 526225002297 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526225002298 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 526225002299 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 526225002300 active site 526225002301 Zn binding site [ion binding]; other site 526225002302 RNHCP domain; Region: RNHCP; pfam12647 526225002303 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 526225002304 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 526225002305 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 526225002306 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 526225002307 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 526225002308 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 526225002309 catalytic residues [active] 526225002310 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225002311 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 526225002312 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 526225002313 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 526225002314 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 526225002315 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 526225002316 catalytic residue [active] 526225002317 putative FPP diphosphate binding site; other site 526225002318 putative FPP binding hydrophobic cleft; other site 526225002319 dimer interface [polypeptide binding]; other site 526225002320 putative IPP diphosphate binding site; other site 526225002321 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 526225002322 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 526225002323 putative active site [active] 526225002324 PhoH-like protein; Region: PhoH; pfam02562 526225002325 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 526225002326 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 526225002327 FHIPEP family; Region: FHIPEP; pfam00771 526225002328 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 526225002329 YacP-like NYN domain; Region: NYN_YacP; cl01491 526225002330 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 526225002331 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 526225002332 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 526225002333 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 526225002334 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 526225002335 flagellar motor switch protein FliN; Region: fliN; TIGR02480 526225002336 Flagellar motor switch protein FliM; Region: FliM; pfam02154 526225002337 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 526225002338 flagellar motor protein MotS; Reviewed; Region: PRK06925 526225002339 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 526225002340 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 526225002341 ligand binding site [chemical binding]; other site 526225002342 flagellar motor protein MotA; Validated; Region: PRK08124 526225002343 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 526225002344 Flagellar protein (FlbD); Region: FlbD; pfam06289 526225002345 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 526225002346 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 526225002347 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 526225002348 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 526225002349 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 526225002350 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 526225002351 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 526225002352 NlpC/P60 family; Region: NLPC_P60; pfam00877 526225002353 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 526225002354 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 526225002355 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526225002356 catalytic residue [active] 526225002357 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 526225002358 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 526225002359 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 526225002360 Walker A motif/ATP binding site; other site 526225002361 Walker B motif; other site 526225002362 Flagellar assembly protein FliH; Region: FliH; pfam02108 526225002363 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 526225002364 FliG C-terminal domain; Region: FliG_C; pfam01706 526225002365 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 526225002366 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 526225002367 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 526225002368 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 526225002369 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 526225002370 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 526225002371 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 526225002372 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 526225002373 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 526225002374 Flagellar protein FliS; Region: FliS; cl00654 526225002375 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 526225002376 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 526225002377 flagellin; Provisional; Region: PRK12804 526225002378 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 526225002379 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 526225002380 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 526225002381 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 526225002382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225002383 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526225002384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225002385 DNA binding residues [nucleotide binding] 526225002386 FlgN protein; Region: FlgN; pfam05130 526225002387 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 526225002388 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 526225002389 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 526225002390 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 526225002391 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 526225002392 FliW protein; Region: FliW; pfam02623 526225002393 Global regulator protein family; Region: CsrA; pfam02599 526225002394 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 526225002395 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 526225002396 NlpC/P60 family; Region: NLPC_P60; cl17555 526225002397 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 526225002398 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 526225002399 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 526225002400 dimer interface [polypeptide binding]; other site 526225002401 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 526225002402 active site 526225002403 citrylCoA binding site [chemical binding]; other site 526225002404 NADH binding [chemical binding]; other site 526225002405 cationic pore residues; other site 526225002406 oxalacetate/citrate binding site [chemical binding]; other site 526225002407 coenzyme A binding site [chemical binding]; other site 526225002408 catalytic triad [active] 526225002409 fumarate hydratase; Reviewed; Region: fumC; PRK00485 526225002410 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 526225002411 active sites [active] 526225002412 tetramer interface [polypeptide binding]; other site 526225002413 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 526225002414 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 526225002415 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 526225002416 putative active site [active] 526225002417 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 526225002418 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 526225002419 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 526225002420 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 526225002421 generic binding surface II; other site 526225002422 generic binding surface I; other site 526225002423 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 526225002424 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 526225002425 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 526225002426 RmuC family; Region: RmuC; pfam02646 526225002427 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 526225002428 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 526225002429 DNA binding site [nucleotide binding] 526225002430 active site 526225002431 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 526225002432 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 526225002433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225002434 AlkA N-terminal domain; Region: AlkA_N; smart01009 526225002435 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 526225002436 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 526225002437 minor groove reading motif; other site 526225002438 helix-hairpin-helix signature motif; other site 526225002439 substrate binding pocket [chemical binding]; other site 526225002440 active site 526225002441 Ligand Binding Site [chemical binding]; other site 526225002442 Universal stress protein family; Region: Usp; pfam00582 526225002443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225002444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225002445 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 526225002446 Isochorismatase family; Region: Isochorismatase; pfam00857 526225002447 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 526225002448 catalytic triad [active] 526225002449 conserved cis-peptide bond; other site 526225002450 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 526225002451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225002452 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225002453 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 526225002454 uncharacterized domain; Region: TIGR00702 526225002455 YcaO-like family; Region: YcaO; pfam02624 526225002456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225002457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225002458 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225002459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225002460 S-adenosylmethionine binding site [chemical binding]; other site 526225002461 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 526225002462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225002463 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526225002464 Walker A/P-loop; other site 526225002465 ATP binding site [chemical binding]; other site 526225002466 Q-loop/lid; other site 526225002467 ABC transporter signature motif; other site 526225002468 Walker B; other site 526225002469 D-loop; other site 526225002470 H-loop/switch region; other site 526225002471 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526225002472 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 526225002473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225002474 Histidine kinase; Region: HisKA_3; pfam07730 526225002475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225002476 ATP binding site [chemical binding]; other site 526225002477 Mg2+ binding site [ion binding]; other site 526225002478 G-X-G motif; other site 526225002479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225002480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225002481 active site 526225002482 phosphorylation site [posttranslational modification] 526225002483 intermolecular recognition site; other site 526225002484 dimerization interface [polypeptide binding]; other site 526225002485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225002486 dimerization interface [polypeptide binding]; other site 526225002487 DNA binding residues [nucleotide binding] 526225002488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225002489 Coenzyme A binding pocket [chemical binding]; other site 526225002490 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 526225002491 GTP-binding protein YchF; Reviewed; Region: PRK09601 526225002492 YchF GTPase; Region: YchF; cd01900 526225002493 G1 box; other site 526225002494 GTP/Mg2+ binding site [chemical binding]; other site 526225002495 Switch I region; other site 526225002496 G2 box; other site 526225002497 Switch II region; other site 526225002498 G3 box; other site 526225002499 G4 box; other site 526225002500 G5 box; other site 526225002501 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 526225002502 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 526225002503 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 526225002504 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 526225002505 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526225002506 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 526225002507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 526225002508 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526225002509 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225002510 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 526225002511 putative hydrophobic ligand binding site [chemical binding]; other site 526225002512 Patatin-like phospholipase; Region: Patatin; pfam01734 526225002513 nucleophile elbow; other site 526225002514 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225002515 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 526225002516 NAD(P) binding site [chemical binding]; other site 526225002517 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 526225002518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225002519 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225002520 active site 526225002521 catalytic tetrad [active] 526225002522 PspC domain; Region: PspC; pfam04024 526225002523 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 526225002524 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 526225002525 4Fe-4S binding domain; Region: Fer4; pfam00037 526225002526 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 526225002527 L-aspartate oxidase; Provisional; Region: PRK06175 526225002528 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 526225002529 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 526225002530 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 526225002531 putative Iron-sulfur protein interface [polypeptide binding]; other site 526225002532 proximal heme binding site [chemical binding]; other site 526225002533 distal heme binding site [chemical binding]; other site 526225002534 putative dimer interface [polypeptide binding]; other site 526225002535 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 526225002536 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 526225002537 Moco binding site; other site 526225002538 metal coordination site [ion binding]; other site 526225002539 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 526225002540 FAD binding pocket [chemical binding]; other site 526225002541 conserved FAD binding motif [chemical binding]; other site 526225002542 phosphate binding motif [ion binding]; other site 526225002543 beta-alpha-beta structure motif; other site 526225002544 NAD binding pocket [chemical binding]; other site 526225002545 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 526225002546 Zn binding site [ion binding]; other site 526225002547 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 526225002548 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 526225002549 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 526225002550 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 526225002551 AAA ATPase domain; Region: AAA_16; pfam13191 526225002552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225002553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225002554 dimerization interface [polypeptide binding]; other site 526225002555 DNA binding residues [nucleotide binding] 526225002556 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 526225002557 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 526225002558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 526225002559 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 526225002560 aromatic arch; other site 526225002561 DCoH dimer interaction site [polypeptide binding]; other site 526225002562 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 526225002563 DCoH tetramer interaction site [polypeptide binding]; other site 526225002564 substrate binding site [chemical binding]; other site 526225002565 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 526225002566 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 526225002567 Active Sites [active] 526225002568 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 526225002569 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 526225002570 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 526225002571 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 526225002572 ligand-binding site [chemical binding]; other site 526225002573 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 526225002574 Transcriptional regulator; Region: Rrf2; pfam02082 526225002575 Transcriptional regulator; Region: Rrf2; cl17282 526225002576 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 526225002577 active site 526225002578 8-oxo-dGMP binding site [chemical binding]; other site 526225002579 nudix motif; other site 526225002580 metal binding site [ion binding]; metal-binding site 526225002581 CsbD-like; Region: CsbD; pfam05532 526225002582 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 526225002583 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526225002584 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 526225002585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225002586 dimer interface [polypeptide binding]; other site 526225002587 conserved gate region; other site 526225002588 putative PBP binding loops; other site 526225002589 ABC-ATPase subunit interface; other site 526225002590 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 526225002591 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 526225002592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225002593 dimer interface [polypeptide binding]; other site 526225002594 conserved gate region; other site 526225002595 putative PBP binding loops; other site 526225002596 ABC-ATPase subunit interface; other site 526225002597 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 526225002598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526225002599 Walker A/P-loop; other site 526225002600 ATP binding site [chemical binding]; other site 526225002601 Q-loop/lid; other site 526225002602 ABC transporter signature motif; other site 526225002603 Walker B; other site 526225002604 D-loop; other site 526225002605 H-loop/switch region; other site 526225002606 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 526225002607 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 526225002608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 526225002609 Walker A/P-loop; other site 526225002610 ATP binding site [chemical binding]; other site 526225002611 Q-loop/lid; other site 526225002612 ABC transporter signature motif; other site 526225002613 Walker B; other site 526225002614 D-loop; other site 526225002615 H-loop/switch region; other site 526225002616 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 526225002617 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 526225002618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225002619 Coenzyme A binding pocket [chemical binding]; other site 526225002620 Ferredoxin [Energy production and conversion]; Region: COG1146 526225002621 4Fe-4S binding domain; Region: Fer4; pfam00037 526225002622 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 526225002623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526225002624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225002625 homodimer interface [polypeptide binding]; other site 526225002626 catalytic residue [active] 526225002627 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 526225002628 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 526225002629 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225002630 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 526225002631 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 526225002632 putative trimer interface [polypeptide binding]; other site 526225002633 putative CoA binding site [chemical binding]; other site 526225002634 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 526225002635 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 526225002636 metal binding site [ion binding]; metal-binding site 526225002637 putative dimer interface [polypeptide binding]; other site 526225002638 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 526225002639 DivIVA domain; Region: DivI1A_domain; TIGR03544 526225002640 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 526225002641 hydrophobic ligand binding site; other site 526225002642 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 526225002643 EamA-like transporter family; Region: EamA; pfam00892 526225002644 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 526225002645 Fibronectin type 3 domain; Region: FN3; smart00060 526225002646 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 526225002647 Interdomain contacts; other site 526225002648 Cytokine receptor motif; other site 526225002649 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 526225002650 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 526225002651 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 526225002652 interface (dimer of trimers) [polypeptide binding]; other site 526225002653 Substrate-binding/catalytic site; other site 526225002654 Zn-binding sites [ion binding]; other site 526225002655 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 526225002656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225002657 DNA-binding site [nucleotide binding]; DNA binding site 526225002658 phytoene desaturase; Region: crtI_fam; TIGR02734 526225002659 PAS fold; Region: PAS_4; pfam08448 526225002660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225002661 putative active site [active] 526225002662 heme pocket [chemical binding]; other site 526225002663 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225002664 GAF domain; Region: GAF_2; pfam13185 526225002665 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225002666 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 526225002667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225002668 FeS/SAM binding site; other site 526225002669 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 526225002670 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 526225002671 Catalytic site [active] 526225002672 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 526225002673 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 526225002674 Multicopper oxidase; Region: Cu-oxidase; pfam00394 526225002675 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 526225002676 Histidine kinase; Region: HisKA_3; pfam07730 526225002677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 526225002678 Mg2+ binding site [ion binding]; other site 526225002679 G-X-G motif; other site 526225002680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225002681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225002682 active site 526225002683 phosphorylation site [posttranslational modification] 526225002684 intermolecular recognition site; other site 526225002685 dimerization interface [polypeptide binding]; other site 526225002686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225002687 DNA binding residues [nucleotide binding] 526225002688 dimerization interface [polypeptide binding]; other site 526225002689 Response regulator receiver domain; Region: Response_reg; pfam00072 526225002690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225002691 active site 526225002692 phosphorylation site [posttranslational modification] 526225002693 intermolecular recognition site; other site 526225002694 dimerization interface [polypeptide binding]; other site 526225002695 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 526225002696 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225002697 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 526225002698 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 526225002699 ligand binding site; other site 526225002700 oligomer interface; other site 526225002701 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 526225002702 dimer interface [polypeptide binding]; other site 526225002703 N-terminal domain interface [polypeptide binding]; other site 526225002704 sulfate 1 binding site; other site 526225002705 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 526225002706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 526225002707 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 526225002708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225002709 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225002710 DNA binding residues [nucleotide binding] 526225002711 Putative zinc-finger; Region: zf-HC2; pfam13490 526225002712 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 526225002713 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526225002714 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526225002715 protein binding site [polypeptide binding]; other site 526225002716 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 526225002717 Domain of unknown function DUF59; Region: DUF59; cl00941 526225002718 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 526225002719 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 526225002720 AzlC protein; Region: AzlC; pfam03591 526225002721 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526225002722 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225002723 DNA binding residues [nucleotide binding] 526225002724 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 526225002725 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 526225002726 MgtE intracellular N domain; Region: MgtE_N; smart00924 526225002727 FOG: CBS domain [General function prediction only]; Region: COG0517 526225002728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 526225002729 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 526225002730 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 526225002731 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 526225002732 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225002733 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225002734 active site 526225002735 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 526225002736 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 526225002737 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225002738 putative NAD(P) binding site [chemical binding]; other site 526225002739 EthD domain; Region: EthD; cl17553 526225002740 hypothetical protein; Validated; Region: PRK07586 526225002741 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 526225002742 PYR/PP interface [polypeptide binding]; other site 526225002743 dimer interface [polypeptide binding]; other site 526225002744 TPP binding site [chemical binding]; other site 526225002745 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 526225002746 TPP-binding site [chemical binding]; other site 526225002747 dimer interface [polypeptide binding]; other site 526225002748 OsmC-like protein; Region: OsmC; pfam02566 526225002749 patatin-related protein; Region: TIGR03607 526225002750 Patatin-like phospholipase; Region: Patatin; pfam01734 526225002751 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 526225002752 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 526225002753 catalytic residues [active] 526225002754 catalytic nucleophile [active] 526225002755 Recombinase; Region: Recombinase; pfam07508 526225002756 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 526225002757 CHAT domain; Region: CHAT; pfam12770 526225002758 SIR2-like domain; Region: SIR2_2; pfam13289 526225002759 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225002760 SIR2-like domain; Region: SIR2_2; pfam13289 526225002761 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526225002762 structural tetrad; other site 526225002763 FOG: WD40 repeat [General function prediction only]; Region: COG2319 526225002764 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526225002765 structural tetrad; other site 526225002766 WD40 repeats; Region: WD40; smart00320 526225002767 WD domain, G-beta repeat; Region: WD40; pfam00400 526225002768 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 526225002769 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526225002770 active site 526225002771 metal binding site [ion binding]; metal-binding site 526225002772 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 526225002773 TIR domain; Region: TIR_2; pfam13676 526225002774 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 526225002775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225002776 catalytic residue [active] 526225002777 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 526225002778 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 526225002779 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 526225002780 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225002781 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 526225002782 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526225002783 active site 526225002784 Lsr2; Region: Lsr2; pfam11774 526225002785 SnoaL-like domain; Region: SnoaL_2; pfam12680 526225002786 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 526225002787 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526225002788 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 526225002789 PA/protease or protease-like domain interface [polypeptide binding]; other site 526225002790 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 526225002791 Peptidase family M28; Region: Peptidase_M28; pfam04389 526225002792 active site 526225002793 metal binding site [ion binding]; metal-binding site 526225002794 Transposase; Region: DDE_Tnp_ISL3; pfam01610 526225002795 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 526225002796 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 526225002797 putative dimer interface [polypeptide binding]; other site 526225002798 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 526225002799 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 526225002800 active site 526225002801 Zn binding site [ion binding]; other site 526225002802 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 526225002803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225002804 active site 526225002805 motif I; other site 526225002806 motif II; other site 526225002807 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 526225002808 metal binding site [ion binding]; metal-binding site 526225002809 Peptidase family M28; Region: Peptidase_M28; pfam04389 526225002810 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 526225002811 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225002812 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225002813 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225002814 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526225002815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 526225002816 putative transposase OrfB; Reviewed; Region: PHA02517 526225002817 HTH-like domain; Region: HTH_21; pfam13276 526225002818 Integrase core domain; Region: rve; pfam00665 526225002819 Integrase core domain; Region: rve_3; pfam13683 526225002820 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 526225002821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225002822 DDE superfamily endonuclease; Region: DDE_4; pfam13359 526225002823 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 526225002824 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 526225002825 active site 526225002826 catalytic site [active] 526225002827 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 526225002828 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 526225002829 putative transposase OrfB; Reviewed; Region: PHA02517 526225002830 HTH-like domain; Region: HTH_21; pfam13276 526225002831 Integrase core domain; Region: rve; pfam00665 526225002832 Integrase core domain; Region: rve_2; pfam13333 526225002833 Transposase; Region: HTH_Tnp_1; cl17663 526225002834 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 526225002835 substrate binding site [chemical binding]; other site 526225002836 homodimer interface [polypeptide binding]; other site 526225002837 heme binding site [chemical binding]; other site 526225002838 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 526225002839 putative heme binding pocket [chemical binding]; other site 526225002840 Bacterial transcriptional activator domain; Region: BTAD; smart01043 526225002841 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 526225002842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225002843 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 526225002844 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 526225002845 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 526225002846 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 526225002847 PAS fold; Region: PAS; pfam00989 526225002848 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225002849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225002850 metal binding site [ion binding]; metal-binding site 526225002851 active site 526225002852 I-site; other site 526225002853 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225002854 peptide chain release factor 2; Validated; Region: prfB; PRK00578 526225002855 This domain is found in peptide chain release factors; Region: PCRF; smart00937 526225002856 RF-1 domain; Region: RF-1; pfam00472 526225002857 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 526225002858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225002859 Walker A/P-loop; other site 526225002860 ATP binding site [chemical binding]; other site 526225002861 Q-loop/lid; other site 526225002862 ABC transporter signature motif; other site 526225002863 Walker B; other site 526225002864 D-loop; other site 526225002865 H-loop/switch region; other site 526225002866 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 526225002867 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 526225002868 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 526225002869 SmpB-tmRNA interface; other site 526225002870 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225002871 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 526225002872 putative NAD(P) binding site [chemical binding]; other site 526225002873 Amidohydrolase; Region: Amidohydro_4; pfam13147 526225002874 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 526225002875 active site 526225002876 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 526225002877 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 526225002878 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225002879 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 526225002880 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 526225002881 active site 526225002882 Uncharacterized conserved protein [Function unknown]; Region: COG2128 526225002883 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 526225002884 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 526225002885 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 526225002886 oligomer interface [polypeptide binding]; other site 526225002887 metal binding site [ion binding]; metal-binding site 526225002888 metal binding site [ion binding]; metal-binding site 526225002889 putative Cl binding site [ion binding]; other site 526225002890 basic sphincter; other site 526225002891 hydrophobic gate; other site 526225002892 periplasmic entrance; other site 526225002893 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 526225002894 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 526225002895 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 526225002896 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526225002897 catalytic residue [active] 526225002898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225002899 PAS fold; Region: PAS_3; pfam08447 526225002900 putative active site [active] 526225002901 heme pocket [chemical binding]; other site 526225002902 PAS domain; Region: PAS_9; pfam13426 526225002903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225002904 putative active site [active] 526225002905 heme pocket [chemical binding]; other site 526225002906 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225002907 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225002908 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225002909 Ion channel; Region: Ion_trans_2; pfam07885 526225002910 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 526225002911 TrkA-N domain; Region: TrkA_N; pfam02254 526225002912 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 526225002913 active site 526225002914 nucleophile elbow; other site 526225002915 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 526225002916 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 526225002917 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 526225002918 putative active site [active] 526225002919 catalytic site [active] 526225002920 putative metal binding site [ion binding]; other site 526225002921 TIR domain; Region: TIR_2; pfam13676 526225002922 AAA ATPase domain; Region: AAA_16; pfam13191 526225002923 NB-ARC domain; Region: NB-ARC; pfam00931 526225002924 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526225002925 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 526225002926 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 526225002927 catalytic residues [active] 526225002928 MarR family; Region: MarR_2; pfam12802 526225002929 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225002930 MarR family; Region: MarR_2; cl17246 526225002931 Uncharacterized conserved protein [Function unknown]; Region: COG2353 526225002932 hypothetical protein; Provisional; Region: PRK07236 526225002933 hypothetical protein; Provisional; Region: PRK07588 526225002934 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 526225002935 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 526225002936 G1 box; other site 526225002937 putative GEF interaction site [polypeptide binding]; other site 526225002938 GTP/Mg2+ binding site [chemical binding]; other site 526225002939 Switch I region; other site 526225002940 G2 box; other site 526225002941 G3 box; other site 526225002942 Switch II region; other site 526225002943 G4 box; other site 526225002944 G5 box; other site 526225002945 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 526225002946 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 526225002947 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 526225002948 active site 526225002949 catalytic residues [active] 526225002950 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225002951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225002952 NAD(P) binding site [chemical binding]; other site 526225002953 active site 526225002954 Predicted permeases [General function prediction only]; Region: COG0730 526225002955 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 526225002956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225002957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225002958 DNA binding residues [nucleotide binding] 526225002959 CopC domain; Region: CopC; pfam04234 526225002960 YtkA-like; Region: YtkA; pfam13115 526225002961 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 526225002962 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 526225002963 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 526225002964 Cu(I) binding site [ion binding]; other site 526225002965 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 526225002966 active site 526225002967 metal-binding site 526225002968 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 526225002969 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 526225002970 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 526225002971 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225002972 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 526225002973 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 526225002974 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 526225002975 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526225002976 Peptidase family M23; Region: Peptidase_M23; pfam01551 526225002977 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 526225002978 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 526225002979 Putative cyclase; Region: Cyclase; pfam04199 526225002980 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 526225002981 homotrimer interaction site [polypeptide binding]; other site 526225002982 putative active site [active] 526225002983 Predicted transcriptional regulators [Transcription]; Region: COG1733 526225002984 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 526225002985 Muconolactone delta-isomerase; Region: MIase; pfam02426 526225002986 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 526225002987 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 526225002988 active site 526225002989 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 526225002990 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 526225002991 active site 526225002992 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 526225002993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526225002994 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 526225002995 dimerization interface [polypeptide binding]; other site 526225002996 substrate binding pocket [chemical binding]; other site 526225002997 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 526225002998 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 526225002999 iron-sulfur cluster [ion binding]; other site 526225003000 [2Fe-2S] cluster binding site [ion binding]; other site 526225003001 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 526225003002 putative alpha subunit interface [polypeptide binding]; other site 526225003003 putative active site [active] 526225003004 putative substrate binding site [chemical binding]; other site 526225003005 Fe binding site [ion binding]; other site 526225003006 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 526225003007 inter-subunit interface; other site 526225003008 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 526225003009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225003010 catalytic loop [active] 526225003011 iron binding site [ion binding]; other site 526225003012 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 526225003013 FAD binding pocket [chemical binding]; other site 526225003014 FAD binding motif [chemical binding]; other site 526225003015 phosphate binding motif [ion binding]; other site 526225003016 beta-alpha-beta structure motif; other site 526225003017 NAD binding pocket [chemical binding]; other site 526225003018 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 526225003019 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 526225003020 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 526225003021 putative NAD(P) binding site [chemical binding]; other site 526225003022 active site 526225003023 AAA ATPase domain; Region: AAA_16; pfam13191 526225003024 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225003025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225003026 DNA binding residues [nucleotide binding] 526225003027 dimerization interface [polypeptide binding]; other site 526225003028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225003029 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 526225003030 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 526225003031 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225003032 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225003033 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 526225003034 GAF domain; Region: GAF_2; pfam13185 526225003035 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 526225003036 Sodium Bile acid symporter family; Region: SBF; cl17470 526225003037 Flagellar protein (FlbD); Region: FlbD; pfam06289 526225003038 Methyltransferase domain; Region: Methyltransf_12; pfam08242 526225003039 S-adenosylmethionine binding site [chemical binding]; other site 526225003040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225003041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225003042 active site 526225003043 phosphorylation site [posttranslational modification] 526225003044 intermolecular recognition site; other site 526225003045 dimerization interface [polypeptide binding]; other site 526225003046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225003047 DNA binding site [nucleotide binding] 526225003048 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 526225003049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225003050 putative active site [active] 526225003051 heme pocket [chemical binding]; other site 526225003052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225003053 dimer interface [polypeptide binding]; other site 526225003054 phosphorylation site [posttranslational modification] 526225003055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225003056 ATP binding site [chemical binding]; other site 526225003057 Mg2+ binding site [ion binding]; other site 526225003058 G-X-G motif; other site 526225003059 Response regulator receiver domain; Region: Response_reg; pfam00072 526225003060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225003061 active site 526225003062 phosphorylation site [posttranslational modification] 526225003063 intermolecular recognition site; other site 526225003064 dimerization interface [polypeptide binding]; other site 526225003065 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 526225003066 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 526225003067 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 526225003068 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 526225003069 FAD binding pocket [chemical binding]; other site 526225003070 FAD binding motif [chemical binding]; other site 526225003071 phosphate binding motif [ion binding]; other site 526225003072 NAD binding pocket [chemical binding]; other site 526225003073 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 526225003074 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 526225003075 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 526225003076 Domain of unknown function (DUF385); Region: DUF385; pfam04075 526225003077 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 526225003078 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 526225003079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225003080 NAD(P) binding site [chemical binding]; other site 526225003081 active site 526225003082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225003083 S-adenosylmethionine binding site [chemical binding]; other site 526225003084 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 526225003085 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 526225003086 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526225003087 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 526225003088 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526225003089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225003090 Walker A/P-loop; other site 526225003091 ATP binding site [chemical binding]; other site 526225003092 Q-loop/lid; other site 526225003093 ABC transporter signature motif; other site 526225003094 Walker B; other site 526225003095 D-loop; other site 526225003096 H-loop/switch region; other site 526225003097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225003098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225003099 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225003100 active site 526225003101 catalytic tetrad [active] 526225003102 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 526225003103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225003104 putative substrate translocation pore; other site 526225003105 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 526225003106 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526225003107 NAD binding site [chemical binding]; other site 526225003108 catalytic Zn binding site [ion binding]; other site 526225003109 structural Zn binding site [ion binding]; other site 526225003110 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526225003111 Peptidase family M23; Region: Peptidase_M23; pfam01551 526225003112 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 526225003113 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 526225003114 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 526225003115 homotetramer interface [polypeptide binding]; other site 526225003116 active site 526225003117 metal binding site [ion binding]; metal-binding site 526225003118 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 526225003119 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 526225003120 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 526225003121 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 526225003122 D-pathway; other site 526225003123 Putative ubiquinol binding site [chemical binding]; other site 526225003124 Low-spin heme (heme b) binding site [chemical binding]; other site 526225003125 Putative water exit pathway; other site 526225003126 Binuclear center (heme o3/CuB) [ion binding]; other site 526225003127 K-pathway; other site 526225003128 Putative proton exit pathway; other site 526225003129 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 526225003130 phosphoserine phosphatase SerB; Region: serB; TIGR00338 526225003131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225003132 motif II; other site 526225003133 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 526225003134 Isochorismatase family; Region: Isochorismatase; pfam00857 526225003135 catalytic triad [active] 526225003136 metal binding site [ion binding]; metal-binding site 526225003137 conserved cis-peptide bond; other site 526225003138 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 526225003139 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 526225003140 active site 526225003141 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 526225003142 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 526225003143 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 526225003144 MPN+ (JAMM) motif; other site 526225003145 Zinc-binding site [ion binding]; other site 526225003146 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 526225003147 MoaE interaction surface [polypeptide binding]; other site 526225003148 MoeB interaction surface [polypeptide binding]; other site 526225003149 thiocarboxylated glycine; other site 526225003150 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 526225003151 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 526225003152 dimer interface [polypeptide binding]; other site 526225003153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225003154 catalytic residue [active] 526225003155 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 526225003156 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 526225003157 nucleotide binding site [chemical binding]; other site 526225003158 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 526225003159 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 526225003160 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 526225003161 catalytic triad [active] 526225003162 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 526225003163 ribonuclease PH; Reviewed; Region: rph; PRK00173 526225003164 Ribonuclease PH; Region: RNase_PH_bact; cd11362 526225003165 hexamer interface [polypeptide binding]; other site 526225003166 active site 526225003167 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 526225003168 active site 526225003169 dimerization interface [polypeptide binding]; other site 526225003170 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 526225003171 Domain of unknown function (DUF427); Region: DUF427; pfam04248 526225003172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225003173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225003174 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225003175 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225003176 catalytic core [active] 526225003177 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225003178 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225003179 active site 526225003180 catalytic tetrad [active] 526225003181 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225003182 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225003183 active site 526225003184 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225003185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225003186 NAD(P) binding site [chemical binding]; other site 526225003187 active site 526225003188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225003189 putative substrate translocation pore; other site 526225003190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225003191 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 526225003192 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 526225003193 active site 526225003194 metal binding site [ion binding]; metal-binding site 526225003195 nudix motif; other site 526225003196 TIGR03086 family protein; Region: TIGR03086 526225003197 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 526225003198 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 526225003199 NodB motif; other site 526225003200 active site 526225003201 catalytic site [active] 526225003202 metal binding site [ion binding]; metal-binding site 526225003203 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526225003204 classical (c) SDRs; Region: SDR_c; cd05233 526225003205 NAD(P) binding site [chemical binding]; other site 526225003206 active site 526225003207 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 526225003208 dimerization interface [polypeptide binding]; other site 526225003209 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 526225003210 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225003211 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 526225003212 putative dimer interface [polypeptide binding]; other site 526225003213 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225003214 Berberine and berberine like; Region: BBE; pfam08031 526225003215 stage V sporulation protein K; Region: spore_V_K; TIGR02881 526225003216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225003217 Walker A motif; other site 526225003218 ATP binding site [chemical binding]; other site 526225003219 Walker B motif; other site 526225003220 arginine finger; other site 526225003221 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 526225003222 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 526225003223 catalytic residues [active] 526225003224 catalytic nucleophile [active] 526225003225 Presynaptic Site I dimer interface [polypeptide binding]; other site 526225003226 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 526225003227 Synaptic Flat tetramer interface [polypeptide binding]; other site 526225003228 Synaptic Site I dimer interface [polypeptide binding]; other site 526225003229 DNA binding site [nucleotide binding] 526225003230 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 526225003231 DNA-binding interface [nucleotide binding]; DNA binding site 526225003232 putative lipid kinase; Reviewed; Region: PRK13057 526225003233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225003234 putative DNA binding site [nucleotide binding]; other site 526225003235 putative Zn2+ binding site [ion binding]; other site 526225003236 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 526225003237 putative hydrophobic ligand binding site [chemical binding]; other site 526225003238 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 526225003239 active site 526225003240 NTP binding site [chemical binding]; other site 526225003241 metal binding triad [ion binding]; metal-binding site 526225003242 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 526225003243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225003244 SnoaL-like domain; Region: SnoaL_2; pfam12680 526225003245 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225003246 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225003247 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225003248 TIR domain; Region: TIR_2; pfam13676 526225003249 NB-ARC domain; Region: NB-ARC; pfam00931 526225003250 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225003251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225003252 S-adenosylmethionine binding site [chemical binding]; other site 526225003253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 526225003254 OsmC-like protein; Region: OsmC; pfam02566 526225003255 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225003256 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 526225003257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225003258 non-specific DNA binding site [nucleotide binding]; other site 526225003259 salt bridge; other site 526225003260 sequence-specific DNA binding site [nucleotide binding]; other site 526225003261 RibD C-terminal domain; Region: RibD_C; cl17279 526225003262 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 526225003263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225003264 PAS fold; Region: PAS_2; pfam08446 526225003265 GAF domain; Region: GAF; pfam01590 526225003266 Phytochrome region; Region: PHY; pfam00360 526225003267 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225003268 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 526225003269 heme binding pocket [chemical binding]; other site 526225003270 heme ligand [chemical binding]; other site 526225003271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225003272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225003273 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 526225003274 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225003275 Proline dehydrogenase; Region: Pro_dh; cl03282 526225003276 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 526225003277 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 526225003278 Glutamate binding site [chemical binding]; other site 526225003279 NAD binding site [chemical binding]; other site 526225003280 catalytic residues [active] 526225003281 Protein of unknown function, DUF488; Region: DUF488; pfam04343 526225003282 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225003283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225003284 S-adenosylmethionine binding site [chemical binding]; other site 526225003285 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225003286 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 526225003287 Walker A/P-loop; other site 526225003288 ATP binding site [chemical binding]; other site 526225003289 Q-loop/lid; other site 526225003290 ABC transporter signature motif; other site 526225003291 Walker B; other site 526225003292 D-loop; other site 526225003293 H-loop/switch region; other site 526225003294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225003295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225003296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225003297 Ion channel; Region: Ion_trans_2; pfam07885 526225003298 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 526225003299 TrkA-N domain; Region: TrkA_N; pfam02254 526225003300 TrkA-N domain; Region: TrkA_N; pfam02254 526225003301 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 526225003302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225003303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225003304 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 526225003305 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 526225003306 active site 526225003307 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 526225003308 intersubunit interface [polypeptide binding]; other site 526225003309 active site 526225003310 Zn2+ binding site [ion binding]; other site 526225003311 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 526225003312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225003313 DNA-binding site [nucleotide binding]; DNA binding site 526225003314 UTRA domain; Region: UTRA; pfam07702 526225003315 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 526225003316 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 526225003317 ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326 526225003318 dimer interface [polypeptide binding]; other site 526225003319 active site 526225003320 catalytic residue [active] 526225003321 metal binding site [ion binding]; metal-binding site 526225003322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 526225003323 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225003324 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 526225003325 NAD(P) binding site [chemical binding]; other site 526225003326 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 526225003327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225003328 active site 526225003329 DNA binding site [nucleotide binding] 526225003330 Int/Topo IB signature motif; other site 526225003331 Helix-turn-helix domain; Region: HTH_17; pfam12728 526225003332 TrwC relaxase; Region: TrwC; pfam08751 526225003333 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 526225003334 AAA domain; Region: AAA_30; pfam13604 526225003335 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 526225003336 active site 526225003337 catalytic triad [active] 526225003338 oxyanion hole [active] 526225003339 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526225003340 putative active site [active] 526225003341 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 526225003342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 526225003343 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 526225003344 VPS10 domain; Region: VPS10; smart00602 526225003345 Ubiquitin-like proteins; Region: UBQ; cl00155 526225003346 charged pocket; other site 526225003347 hydrophobic patch; other site 526225003348 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225003349 GAF domain; Region: GAF; pfam01590 526225003350 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 526225003351 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 526225003352 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 526225003353 catalytic site [active] 526225003354 putative active site [active] 526225003355 putative substrate binding site [chemical binding]; other site 526225003356 dimer interface [polypeptide binding]; other site 526225003357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225003358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225003359 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 526225003360 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 526225003361 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 526225003362 Ferritin-like domain; Region: Ferritin; pfam00210 526225003363 ferroxidase diiron center [ion binding]; other site 526225003364 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 526225003365 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526225003366 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225003367 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 526225003368 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526225003369 carboxyltransferase (CT) interaction site; other site 526225003370 biotinylation site [posttranslational modification]; other site 526225003371 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225003372 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225003373 active site 526225003374 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 526225003375 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 526225003376 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225003377 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 526225003378 NAD(P) binding site [chemical binding]; other site 526225003379 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 526225003380 dimer interface [polypeptide binding]; other site 526225003381 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225003382 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 526225003383 AAA ATPase domain; Region: AAA_16; pfam13191 526225003384 NACHT domain; Region: NACHT; pfam05729 526225003385 FO synthase; Reviewed; Region: fbiC; PRK09234 526225003386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225003387 FeS/SAM binding site; other site 526225003388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225003389 FeS/SAM binding site; other site 526225003390 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 526225003391 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225003392 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526225003393 Walker A/P-loop; other site 526225003394 ATP binding site [chemical binding]; other site 526225003395 Q-loop/lid; other site 526225003396 ABC transporter signature motif; other site 526225003397 Walker B; other site 526225003398 D-loop; other site 526225003399 H-loop/switch region; other site 526225003400 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 526225003401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225003402 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225003403 DNA binding residues [nucleotide binding] 526225003404 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 526225003405 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 526225003406 dimer interface [polypeptide binding]; other site 526225003407 ADP-ribose binding site [chemical binding]; other site 526225003408 active site 526225003409 nudix motif; other site 526225003410 metal binding site [ion binding]; metal-binding site 526225003411 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 526225003412 active site 526225003413 catalytic triad [active] 526225003414 oxyanion hole [active] 526225003415 PAS domain S-box; Region: sensory_box; TIGR00229 526225003416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225003417 putative active site [active] 526225003418 heme pocket [chemical binding]; other site 526225003419 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225003420 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225003421 metal binding site [ion binding]; metal-binding site 526225003422 active site 526225003423 I-site; other site 526225003424 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225003425 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 526225003426 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 526225003427 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 526225003428 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 526225003429 Mrr N-terminal domain; Region: Mrr_N; pfam14338 526225003430 Restriction endonuclease; Region: Mrr_cat; pfam04471 526225003431 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 526225003432 polymerase nucleotide-binding site; other site 526225003433 DNA-binding residues [nucleotide binding]; DNA binding site 526225003434 nucleotide binding site [chemical binding]; other site 526225003435 primase nucleotide-binding site [nucleotide binding]; other site 526225003436 AAA domain; Region: AAA_25; pfam13481 526225003437 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526225003438 Walker A motif; other site 526225003439 ATP binding site [chemical binding]; other site 526225003440 Walker B motif; other site 526225003441 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 526225003442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526225003443 active site 526225003444 metal binding site [ion binding]; metal-binding site 526225003445 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225003446 active site 526225003447 Int/Topo IB signature motif; other site 526225003448 DNA binding site [nucleotide binding] 526225003449 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225003450 DNA binding site [nucleotide binding] 526225003451 active site 526225003452 Int/Topo IB signature motif; other site 526225003453 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 526225003454 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 526225003455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225003456 Response regulator receiver domain; Region: Response_reg; pfam00072 526225003457 active site 526225003458 phosphorylation site [posttranslational modification] 526225003459 intermolecular recognition site; other site 526225003460 dimerization interface [polypeptide binding]; other site 526225003461 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225003462 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225003463 metal binding site [ion binding]; metal-binding site 526225003464 active site 526225003465 I-site; other site 526225003466 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225003467 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 526225003468 DXD motif; other site 526225003469 Response regulator receiver domain; Region: Response_reg; pfam00072 526225003470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225003471 active site 526225003472 phosphorylation site [posttranslational modification] 526225003473 intermolecular recognition site; other site 526225003474 dimerization interface [polypeptide binding]; other site 526225003475 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225003476 GAF domain; Region: GAF; pfam01590 526225003477 PAS domain S-box; Region: sensory_box; TIGR00229 526225003478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 526225003479 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 526225003480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225003481 putative active site [active] 526225003482 heme pocket [chemical binding]; other site 526225003483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225003484 dimer interface [polypeptide binding]; other site 526225003485 phosphorylation site [posttranslational modification] 526225003486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225003487 ATP binding site [chemical binding]; other site 526225003488 Mg2+ binding site [ion binding]; other site 526225003489 G-X-G motif; other site 526225003490 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526225003491 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526225003492 dimer interface [polypeptide binding]; other site 526225003493 ssDNA binding site [nucleotide binding]; other site 526225003494 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526225003495 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 526225003496 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225003497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225003498 ABC transporter; Region: ABC_tran_2; pfam12848 526225003499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225003500 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526225003501 active site 526225003502 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 526225003503 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526225003504 hypothetical protein; Provisional; Region: PRK11770 526225003505 Domain of unknown function (DUF307); Region: DUF307; pfam03733 526225003506 Domain of unknown function (DUF307); Region: DUF307; pfam03733 526225003507 MOSC domain; Region: MOSC; pfam03473 526225003508 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 526225003509 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 526225003510 Walker A/P-loop; other site 526225003511 ATP binding site [chemical binding]; other site 526225003512 Q-loop/lid; other site 526225003513 ABC transporter signature motif; other site 526225003514 Walker B; other site 526225003515 D-loop; other site 526225003516 H-loop/switch region; other site 526225003517 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 526225003518 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 526225003519 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 526225003520 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526225003521 Walker A/P-loop; other site 526225003522 ATP binding site [chemical binding]; other site 526225003523 Q-loop/lid; other site 526225003524 ABC transporter signature motif; other site 526225003525 Walker B; other site 526225003526 D-loop; other site 526225003527 H-loop/switch region; other site 526225003528 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 526225003529 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 526225003530 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 526225003531 active site 526225003532 catalytic site [active] 526225003533 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526225003534 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 526225003535 apolar tunnel; other site 526225003536 heme binding site [chemical binding]; other site 526225003537 dimerization interface [polypeptide binding]; other site 526225003538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225003539 H+ Antiporter protein; Region: 2A0121; TIGR00900 526225003540 putative substrate translocation pore; other site 526225003541 Mechanosensitive ion channel; Region: MS_channel; pfam00924 526225003542 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 526225003543 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 526225003544 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225003545 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 526225003546 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526225003547 active site 526225003548 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 526225003549 active site 526225003550 catalytic site [active] 526225003551 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526225003552 kynureninase; Region: kynureninase; TIGR01814 526225003553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225003554 catalytic residue [active] 526225003555 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 526225003556 Amidase; Region: Amidase; pfam01425 526225003557 Repair protein; Region: Repair_PSII; pfam04536 526225003558 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 526225003559 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 526225003560 Zn binding site [ion binding]; other site 526225003561 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 526225003562 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 526225003563 catalytic residues [active] 526225003564 Protein of unknown function (DUF429); Region: DUF429; cl12046 526225003565 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 526225003566 hypothetical protein; Provisional; Region: PRK01346 526225003567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225003568 Coenzyme A binding pocket [chemical binding]; other site 526225003569 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 526225003570 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 526225003571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225003572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225003573 DNA binding residues [nucleotide binding] 526225003574 SnoaL-like domain; Region: SnoaL_2; pfam12680 526225003575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 526225003576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526225003577 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 526225003578 dimerization interface [polypeptide binding]; other site 526225003579 substrate binding pocket [chemical binding]; other site 526225003580 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 526225003581 EamA-like transporter family; Region: EamA; pfam00892 526225003582 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 526225003583 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 526225003584 Ligand Binding Site [chemical binding]; other site 526225003585 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 526225003586 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 526225003587 AIR carboxylase; Region: AIRC; smart01001 526225003588 hypothetical protein; Provisional; Region: PRK04194 526225003589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225003590 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225003591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 526225003592 GAF domain; Region: GAF; pfam01590 526225003593 GAF domain; Region: GAF_2; pfam13185 526225003594 ANTAR domain; Region: ANTAR; pfam03861 526225003595 short chain dehydrogenase; Provisional; Region: PRK06180 526225003596 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 526225003597 NADP binding site [chemical binding]; other site 526225003598 active site 526225003599 steroid binding site; other site 526225003600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225003601 salt bridge; other site 526225003602 non-specific DNA binding site [nucleotide binding]; other site 526225003603 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225003604 sequence-specific DNA binding site [nucleotide binding]; other site 526225003605 GAF domain; Region: GAF; pfam01590 526225003606 GAF domain; Region: GAF_2; pfam13185 526225003607 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 526225003608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225003609 putative active site [active] 526225003610 heme pocket [chemical binding]; other site 526225003611 GAF domain; Region: GAF; cl17456 526225003612 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 526225003613 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225003614 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225003615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225003616 ATP binding site [chemical binding]; other site 526225003617 Mg2+ binding site [ion binding]; other site 526225003618 G-X-G motif; other site 526225003619 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 526225003620 intracellular protease, PfpI family; Region: PfpI; TIGR01382 526225003621 proposed catalytic triad [active] 526225003622 conserved cys residue [active] 526225003623 trigger factor; Provisional; Region: tig; PRK01490 526225003624 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 526225003625 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 526225003626 Clp protease; Region: CLP_protease; pfam00574 526225003627 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 526225003628 oligomer interface [polypeptide binding]; other site 526225003629 active site residues [active] 526225003630 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 526225003631 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 526225003632 oligomer interface [polypeptide binding]; other site 526225003633 active site residues [active] 526225003634 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 526225003635 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 526225003636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225003637 Walker A motif; other site 526225003638 ATP binding site [chemical binding]; other site 526225003639 Walker B motif; other site 526225003640 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 526225003641 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 526225003642 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 526225003643 putative active site [active] 526225003644 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 526225003645 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225003646 active site 526225003647 HIGH motif; other site 526225003648 nucleotide binding site [chemical binding]; other site 526225003649 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225003650 active site 526225003651 KMSKS motif; other site 526225003652 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 526225003653 tRNA binding surface [nucleotide binding]; other site 526225003654 anticodon binding site; other site 526225003655 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 526225003656 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526225003657 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526225003658 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 526225003659 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 526225003660 active site 526225003661 multimer interface [polypeptide binding]; other site 526225003662 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 526225003663 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 526225003664 B12 binding site [chemical binding]; other site 526225003665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225003666 FeS/SAM binding site; other site 526225003667 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 526225003668 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 526225003669 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 526225003670 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 526225003671 homodimer interface [polypeptide binding]; other site 526225003672 oligonucleotide binding site [chemical binding]; other site 526225003673 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 526225003674 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 526225003675 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 526225003676 GTPase CgtA; Reviewed; Region: obgE; PRK12296 526225003677 GTP1/OBG; Region: GTP1_OBG; pfam01018 526225003678 Obg GTPase; Region: Obg; cd01898 526225003679 G1 box; other site 526225003680 GTP/Mg2+ binding site [chemical binding]; other site 526225003681 Switch I region; other site 526225003682 G2 box; other site 526225003683 G3 box; other site 526225003684 Switch II region; other site 526225003685 G4 box; other site 526225003686 G5 box; other site 526225003687 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 526225003688 gamma-glutamyl kinase; Provisional; Region: PRK05429 526225003689 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 526225003690 nucleotide binding site [chemical binding]; other site 526225003691 homotetrameric interface [polypeptide binding]; other site 526225003692 putative phosphate binding site [ion binding]; other site 526225003693 putative allosteric binding site; other site 526225003694 PUA domain; Region: PUA; pfam01472 526225003695 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 526225003696 active site 526225003697 catalytic residues [active] 526225003698 metal binding site [ion binding]; metal-binding site 526225003699 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 526225003700 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 526225003701 tetramer interface [polypeptide binding]; other site 526225003702 active site 526225003703 Mg2+/Mn2+ binding site [ion binding]; other site 526225003704 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225003705 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225003706 MarR family; Region: MarR_2; pfam12802 526225003707 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 526225003708 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 526225003709 putative active site [active] 526225003710 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526225003711 metal binding site 2 [ion binding]; metal-binding site 526225003712 putative DNA binding helix; other site 526225003713 metal binding site 1 [ion binding]; metal-binding site 526225003714 dimer interface [polypeptide binding]; other site 526225003715 structural Zn2+ binding site [ion binding]; other site 526225003716 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 526225003717 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526225003718 ABC-ATPase subunit interface; other site 526225003719 dimer interface [polypeptide binding]; other site 526225003720 putative PBP binding regions; other site 526225003721 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526225003722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225003723 Walker A/P-loop; other site 526225003724 ATP binding site [chemical binding]; other site 526225003725 Q-loop/lid; other site 526225003726 ABC transporter signature motif; other site 526225003727 Walker B; other site 526225003728 D-loop; other site 526225003729 H-loop/switch region; other site 526225003730 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526225003731 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 526225003732 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526225003733 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 526225003734 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 526225003735 putative catalytic cysteine [active] 526225003736 MoxR-like ATPases [General function prediction only]; Region: COG0714 526225003737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225003738 Walker A motif; other site 526225003739 ATP binding site [chemical binding]; other site 526225003740 Walker B motif; other site 526225003741 arginine finger; other site 526225003742 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 526225003743 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 526225003744 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 526225003745 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 526225003746 active site 526225003747 (T/H)XGH motif; other site 526225003748 Oligomerisation domain; Region: Oligomerisation; pfam02410 526225003749 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225003750 catalytic core [active] 526225003751 EDD domain protein, DegV family; Region: DegV; TIGR00762 526225003752 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 526225003753 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 526225003754 SLBB domain; Region: SLBB; pfam10531 526225003755 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 526225003756 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 526225003757 hypothetical protein; Reviewed; Region: PRK07914 526225003758 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 526225003759 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 526225003760 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 526225003761 GTP-binding protein LepA; Provisional; Region: PRK05433 526225003762 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 526225003763 G1 box; other site 526225003764 putative GEF interaction site [polypeptide binding]; other site 526225003765 GTP/Mg2+ binding site [chemical binding]; other site 526225003766 Switch I region; other site 526225003767 G2 box; other site 526225003768 G3 box; other site 526225003769 Switch II region; other site 526225003770 G4 box; other site 526225003771 G5 box; other site 526225003772 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 526225003773 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 526225003774 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 526225003775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 526225003776 MOSC domain; Region: MOSC; pfam03473 526225003777 AAA ATPase domain; Region: AAA_16; pfam13191 526225003778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225003779 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 526225003780 DNA binding residues [nucleotide binding] 526225003781 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526225003782 FAD binding domain; Region: FAD_binding_4; pfam01565 526225003783 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526225003784 FAD binding domain; Region: FAD_binding_4; pfam01565 526225003785 Clp amino terminal domain; Region: Clp_N; pfam02861 526225003786 Clp amino terminal domain; Region: Clp_N; pfam02861 526225003787 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 526225003788 putative deacylase active site [active] 526225003789 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225003790 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225003791 NAD(P) binding site [chemical binding]; other site 526225003792 selenophosphate synthetase; Provisional; Region: PRK00943 526225003793 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 526225003794 dimerization interface [polypeptide binding]; other site 526225003795 putative ATP binding site [chemical binding]; other site 526225003796 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 526225003797 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526225003798 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 526225003799 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526225003800 selenocysteine synthase; Provisional; Region: PRK04311 526225003801 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 526225003802 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526225003803 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225003804 catalytic residue [active] 526225003805 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 526225003806 G1 box; other site 526225003807 GTP/Mg2+ binding site [chemical binding]; other site 526225003808 G2 box; other site 526225003809 Switch I region; other site 526225003810 G3 box; other site 526225003811 Switch II region; other site 526225003812 G4 box; other site 526225003813 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 526225003814 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 526225003815 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 526225003816 pentamer interface [polypeptide binding]; other site 526225003817 dodecaamer interface [polypeptide binding]; other site 526225003818 enoyl-CoA hydratase; Provisional; Region: PRK07827 526225003819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225003820 substrate binding site [chemical binding]; other site 526225003821 oxyanion hole (OAH) forming residues; other site 526225003822 trimer interface [polypeptide binding]; other site 526225003823 coproporphyrinogen III oxidase; Validated; Region: PRK05628 526225003824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225003825 FeS/SAM binding site; other site 526225003826 HemN C-terminal domain; Region: HemN_C; pfam06969 526225003827 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225003828 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526225003829 Walker A/P-loop; other site 526225003830 ATP binding site [chemical binding]; other site 526225003831 Q-loop/lid; other site 526225003832 ABC transporter signature motif; other site 526225003833 Walker B; other site 526225003834 D-loop; other site 526225003835 H-loop/switch region; other site 526225003836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225003837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225003838 ATP binding site [chemical binding]; other site 526225003839 Mg2+ binding site [ion binding]; other site 526225003840 G-X-G motif; other site 526225003841 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225003842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225003843 active site 526225003844 phosphorylation site [posttranslational modification] 526225003845 intermolecular recognition site; other site 526225003846 dimerization interface [polypeptide binding]; other site 526225003847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225003848 DNA binding residues [nucleotide binding] 526225003849 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 526225003850 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 526225003851 HTH domain; Region: HTH_11; pfam08279 526225003852 chaperone protein DnaJ; Provisional; Region: PRK14278 526225003853 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 526225003854 HSP70 interaction site [polypeptide binding]; other site 526225003855 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 526225003856 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 526225003857 dimer interface [polypeptide binding]; other site 526225003858 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 526225003859 Protein of unknown function (DUF418); Region: DUF418; pfam04235 526225003860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225003861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225003862 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 526225003863 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 526225003864 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 526225003865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225003866 Walker A/P-loop; other site 526225003867 ATP binding site [chemical binding]; other site 526225003868 Q-loop/lid; other site 526225003869 ABC transporter signature motif; other site 526225003870 Walker B; other site 526225003871 D-loop; other site 526225003872 H-loop/switch region; other site 526225003873 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 526225003874 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 526225003875 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526225003876 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225003877 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526225003878 TM-ABC transporter signature motif; other site 526225003879 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526225003880 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526225003881 TM-ABC transporter signature motif; other site 526225003882 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526225003883 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526225003884 Walker A/P-loop; other site 526225003885 ATP binding site [chemical binding]; other site 526225003886 Q-loop/lid; other site 526225003887 ABC transporter signature motif; other site 526225003888 Walker B; other site 526225003889 D-loop; other site 526225003890 H-loop/switch region; other site 526225003891 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526225003892 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526225003893 Walker A/P-loop; other site 526225003894 ATP binding site [chemical binding]; other site 526225003895 Q-loop/lid; other site 526225003896 ABC transporter signature motif; other site 526225003897 Walker B; other site 526225003898 D-loop; other site 526225003899 H-loop/switch region; other site 526225003900 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 526225003901 nucleotide binding site/active site [active] 526225003902 HIT family signature motif; other site 526225003903 catalytic residue [active] 526225003904 TspO/MBR family; Region: TspO_MBR; cl01379 526225003905 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526225003906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225003907 substrate binding site [chemical binding]; other site 526225003908 oxyanion hole (OAH) forming residues; other site 526225003909 trimer interface [polypeptide binding]; other site 526225003910 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 526225003911 PhoH-like protein; Region: PhoH; pfam02562 526225003912 metal-binding heat shock protein; Provisional; Region: PRK00016 526225003913 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 526225003914 Domain of unknown function DUF21; Region: DUF21; pfam01595 526225003915 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 526225003916 Transporter associated domain; Region: CorC_HlyC; smart01091 526225003917 GTPase Era; Reviewed; Region: era; PRK00089 526225003918 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 526225003919 G1 box; other site 526225003920 GTP/Mg2+ binding site [chemical binding]; other site 526225003921 Switch I region; other site 526225003922 G2 box; other site 526225003923 Switch II region; other site 526225003924 G3 box; other site 526225003925 G4 box; other site 526225003926 KH domain; Region: KH_2; pfam07650 526225003927 Recombination protein O N terminal; Region: RecO_N; pfam11967 526225003928 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 526225003929 Recombination protein O C terminal; Region: RecO_C; pfam02565 526225003930 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 526225003931 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 526225003932 catalytic residue [active] 526225003933 putative FPP diphosphate binding site; other site 526225003934 putative FPP binding hydrophobic cleft; other site 526225003935 dimer interface [polypeptide binding]; other site 526225003936 putative IPP diphosphate binding site; other site 526225003937 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 526225003938 glycyl-tRNA synthetase; Provisional; Region: PRK04173 526225003939 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526225003940 motif 1; other site 526225003941 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 526225003942 active site 526225003943 motif 2; other site 526225003944 motif 3; other site 526225003945 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 526225003946 anticodon binding site; other site 526225003947 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 526225003948 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 526225003949 putative active site [active] 526225003950 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 526225003951 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 526225003952 FMN binding site [chemical binding]; other site 526225003953 active site 526225003954 catalytic residues [active] 526225003955 substrate binding site [chemical binding]; other site 526225003956 pyruvate phosphate dikinase; Provisional; Region: PRK09279 526225003957 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 526225003958 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 526225003959 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 526225003960 Uncharacterized conserved protein [Function unknown]; Region: COG1434 526225003961 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 526225003962 putative active site [active] 526225003963 DNA primase; Validated; Region: dnaG; PRK05667 526225003964 CHC2 zinc finger; Region: zf-CHC2; pfam01807 526225003965 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 526225003966 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 526225003967 active site 526225003968 metal binding site [ion binding]; metal-binding site 526225003969 interdomain interaction site; other site 526225003970 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 526225003971 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 526225003972 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 526225003973 AAA ATPase domain; Region: AAA_16; pfam13191 526225003974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225003975 DNA binding residues [nucleotide binding] 526225003976 dimerization interface [polypeptide binding]; other site 526225003977 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 526225003978 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 526225003979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225003980 Walker A/P-loop; other site 526225003981 ATP binding site [chemical binding]; other site 526225003982 Q-loop/lid; other site 526225003983 ABC transporter signature motif; other site 526225003984 Walker B; other site 526225003985 D-loop; other site 526225003986 H-loop/switch region; other site 526225003987 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 526225003988 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225003989 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225003990 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 526225003991 DNA binding site [nucleotide binding] 526225003992 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 526225003993 Predicted ATPase [General function prediction only]; Region: COG3903 526225003994 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 526225003995 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225003996 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 526225003997 putative NAD(P) binding site [chemical binding]; other site 526225003998 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 526225003999 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225004000 catalytic core [active] 526225004001 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 526225004002 putative homotetramer interface [polypeptide binding]; other site 526225004003 putative homodimer interface [polypeptide binding]; other site 526225004004 putative allosteric switch controlling residues; other site 526225004005 putative metal binding site [ion binding]; other site 526225004006 putative homodimer-homodimer interface [polypeptide binding]; other site 526225004007 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526225004008 metal-binding site [ion binding] 526225004009 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 526225004010 NADH dehydrogenase; Region: NADHdh; cl00469 526225004011 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225004012 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225004013 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225004014 NRDE protein; Region: NRDE; cl01315 526225004015 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 526225004016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225004017 Walker A/P-loop; other site 526225004018 ATP binding site [chemical binding]; other site 526225004019 Q-loop/lid; other site 526225004020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225004021 ABC transporter signature motif; other site 526225004022 Walker B; other site 526225004023 D-loop; other site 526225004024 H-loop/switch region; other site 526225004025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225004026 Walker A/P-loop; other site 526225004027 ATP binding site [chemical binding]; other site 526225004028 Q-loop/lid; other site 526225004029 ABC transporter signature motif; other site 526225004030 Walker B; other site 526225004031 D-loop; other site 526225004032 H-loop/switch region; other site 526225004033 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 526225004034 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 526225004035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225004036 catalytic residue [active] 526225004037 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 526225004038 tetramerization interface [polypeptide binding]; other site 526225004039 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526225004040 NAD(P) binding site [chemical binding]; other site 526225004041 catalytic residues [active] 526225004042 BCCT family transporter; Region: BCCT; cl00569 526225004043 choline dehydrogenase; Validated; Region: PRK02106 526225004044 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 526225004045 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160 526225004046 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 526225004047 putative ligand binding site [chemical binding]; other site 526225004048 putative NAD binding site [chemical binding]; other site 526225004049 catalytic site [active] 526225004050 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526225004051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225004052 DNA-binding site [nucleotide binding]; DNA binding site 526225004053 FCD domain; Region: FCD; pfam07729 526225004054 fructuronate transporter; Provisional; Region: PRK10034; cl15264 526225004055 fructuronate transporter; Provisional; Region: PRK10034; cl15264 526225004056 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 526225004057 TPP-binding site [chemical binding]; other site 526225004058 dimer interface [polypeptide binding]; other site 526225004059 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 526225004060 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526225004061 PYR/PP interface [polypeptide binding]; other site 526225004062 dimer interface [polypeptide binding]; other site 526225004063 TPP binding site [chemical binding]; other site 526225004064 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526225004065 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526225004066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225004067 NAD(P) binding site [chemical binding]; other site 526225004068 active site 526225004069 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 526225004070 classical (c) SDRs; Region: SDR_c; cd05233 526225004071 NAD(P) binding site [chemical binding]; other site 526225004072 active site 526225004073 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526225004074 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 526225004075 NAD(P) binding site [chemical binding]; other site 526225004076 catalytic residues [active] 526225004077 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 526225004078 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 526225004079 tetrameric interface [polypeptide binding]; other site 526225004080 NAD binding site [chemical binding]; other site 526225004081 catalytic residues [active] 526225004082 substrate binding site [chemical binding]; other site 526225004083 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 526225004084 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225004085 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 526225004086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526225004087 inhibitor-cofactor binding pocket; inhibition site 526225004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225004089 catalytic residue [active] 526225004090 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 526225004091 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 526225004092 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 526225004093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225004094 putative DNA binding site [nucleotide binding]; other site 526225004095 putative Zn2+ binding site [ion binding]; other site 526225004096 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 526225004097 agmatinase; Region: agmatinase; TIGR01230 526225004098 oligomer interface [polypeptide binding]; other site 526225004099 putative active site [active] 526225004100 Mn binding site [ion binding]; other site 526225004101 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 526225004102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225004103 non-specific DNA binding site [nucleotide binding]; other site 526225004104 salt bridge; other site 526225004105 sequence-specific DNA binding site [nucleotide binding]; other site 526225004106 Cupin domain; Region: Cupin_2; pfam07883 526225004107 amino acid transporter; Region: 2A0306; TIGR00909 526225004108 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 526225004109 Predicted amidohydrolase [General function prediction only]; Region: COG0388 526225004110 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 526225004111 putative active site [active] 526225004112 catalytic triad [active] 526225004113 putative dimer interface [polypeptide binding]; other site 526225004114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225004115 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 526225004116 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526225004117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225004118 Coenzyme A binding pocket [chemical binding]; other site 526225004119 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 526225004120 active site 526225004121 ATP binding site [chemical binding]; other site 526225004122 Phosphotransferase enzyme family; Region: APH; pfam01636 526225004123 substrate binding site [chemical binding]; other site 526225004124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225004125 dimerization interface [polypeptide binding]; other site 526225004126 putative DNA binding site [nucleotide binding]; other site 526225004127 putative Zn2+ binding site [ion binding]; other site 526225004128 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526225004129 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225004130 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225004131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225004132 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 526225004133 active site 526225004134 metal binding site [ion binding]; metal-binding site 526225004135 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526225004136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225004137 substrate binding site [chemical binding]; other site 526225004138 oxyanion hole (OAH) forming residues; other site 526225004139 trimer interface [polypeptide binding]; other site 526225004140 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225004141 tyramine oxidase; Provisional; Region: tynA; PRK11504 526225004142 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 526225004143 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 526225004144 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 526225004145 agmatinase; Region: agmatinase; TIGR01230 526225004146 Agmatinase-like family; Region: Agmatinase-like; cd09990 526225004147 active site 526225004148 oligomer interface [polypeptide binding]; other site 526225004149 Mn binding site [ion binding]; other site 526225004150 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 526225004151 MMPL family; Region: MMPL; pfam03176 526225004152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225004153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225004154 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 526225004155 Amidohydrolase; Region: Amidohydro_2; pfam04909 526225004156 Domain of unknown function DUF59; Region: DUF59; pfam01883 526225004157 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 526225004158 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 526225004159 NAD binding site [chemical binding]; other site 526225004160 substrate binding site [chemical binding]; other site 526225004161 catalytic Zn binding site [ion binding]; other site 526225004162 structural Zn binding site [ion binding]; other site 526225004163 pyruvate carboxylase; Reviewed; Region: PRK12999 526225004164 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526225004165 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225004166 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 526225004167 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 526225004168 active site 526225004169 catalytic residues [active] 526225004170 metal binding site [ion binding]; metal-binding site 526225004171 homodimer binding site [polypeptide binding]; other site 526225004172 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526225004173 carboxyltransferase (CT) interaction site; other site 526225004174 biotinylation site [posttranslational modification]; other site 526225004175 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526225004176 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225004177 active site 526225004178 ATP binding site [chemical binding]; other site 526225004179 substrate binding site [chemical binding]; other site 526225004180 activation loop (A-loop); other site 526225004181 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225004182 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 526225004183 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 526225004184 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 526225004185 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 526225004186 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 526225004187 Cysteine-rich domain; Region: CCG; pfam02754 526225004188 Cysteine-rich domain; Region: CCG; pfam02754 526225004189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526225004190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526225004191 DNA binding site [nucleotide binding] 526225004192 domain linker motif; other site 526225004193 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526225004194 dimerization interface [polypeptide binding]; other site 526225004195 ligand binding site [chemical binding]; other site 526225004196 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 526225004197 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 526225004198 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 526225004199 AAA domain; Region: AAA_33; pfam13671 526225004200 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 526225004201 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 526225004202 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 526225004203 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 526225004204 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 526225004205 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 526225004206 active site residue [active] 526225004207 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 526225004208 active site residue [active] 526225004209 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225004210 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225004211 metal binding site [ion binding]; metal-binding site 526225004212 active site 526225004213 I-site; other site 526225004214 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225004215 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 526225004216 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526225004217 NAD binding site [chemical binding]; other site 526225004218 catalytic Zn binding site [ion binding]; other site 526225004219 structural Zn binding site [ion binding]; other site 526225004220 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 526225004221 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 526225004222 active site 526225004223 catalytic site [active] 526225004224 metal binding site [ion binding]; metal-binding site 526225004225 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 526225004226 putative active site [active] 526225004227 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 526225004228 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 526225004229 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 526225004230 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 526225004231 active site 526225004232 nucleophile elbow; other site 526225004233 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 526225004234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526225004235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225004236 homodimer interface [polypeptide binding]; other site 526225004237 catalytic residue [active] 526225004238 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526225004239 FAD binding domain; Region: FAD_binding_4; pfam01565 526225004240 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 526225004241 Cysteine-rich domain; Region: CCG; pfam02754 526225004242 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 526225004243 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225004244 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 526225004245 dimer interface [polypeptide binding]; other site 526225004246 substrate binding site [chemical binding]; other site 526225004247 metal binding sites [ion binding]; metal-binding site 526225004248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225004249 NADH(P)-binding; Region: NAD_binding_10; pfam13460 526225004250 NAD(P) binding site [chemical binding]; other site 526225004251 active site 526225004252 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 526225004253 active site 526225004254 catalytic site [active] 526225004255 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526225004256 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 526225004257 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225004258 catalytic loop [active] 526225004259 iron binding site [ion binding]; other site 526225004260 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 526225004261 L-aspartate oxidase; Provisional; Region: PRK06175 526225004262 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 526225004263 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 526225004264 catalytic triad [active] 526225004265 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 526225004266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225004267 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 526225004268 Thioredoxin; Region: Thioredoxin_4; pfam13462 526225004269 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 526225004270 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526225004271 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526225004272 ligand binding site [chemical binding]; other site 526225004273 flexible hinge region; other site 526225004274 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 526225004275 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 526225004276 active site 526225004277 catalytic site [active] 526225004278 metal binding site [ion binding]; metal-binding site 526225004279 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225004280 anti sigma factor interaction site; other site 526225004281 regulatory phosphorylation site [posttranslational modification]; other site 526225004282 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 526225004283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225004284 acyl-coenzyme A oxidase; Region: PLN02526 526225004285 active site 526225004286 Ion channel; Region: Ion_trans_2; pfam07885 526225004287 TrkA-N domain; Region: TrkA_N; pfam02254 526225004288 Protein of unknown function (DUF664); Region: DUF664; pfam04978 526225004289 DinB superfamily; Region: DinB_2; pfam12867 526225004290 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225004291 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225004292 active site 526225004293 ATP binding site [chemical binding]; other site 526225004294 substrate binding site [chemical binding]; other site 526225004295 activation loop (A-loop); other site 526225004296 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225004297 Ligand Binding Site [chemical binding]; other site 526225004298 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 526225004299 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 526225004300 amino acid transporter; Region: 2A0306; TIGR00909 526225004301 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 526225004302 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 526225004303 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 526225004304 acyl-activating enzyme (AAE) consensus motif; other site 526225004305 putative AMP binding site [chemical binding]; other site 526225004306 putative active site [active] 526225004307 putative CoA binding site [chemical binding]; other site 526225004308 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 526225004309 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 526225004310 active site 526225004311 NAD binding site [chemical binding]; other site 526225004312 metal binding site [ion binding]; metal-binding site 526225004313 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526225004314 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 526225004315 CoenzymeA binding site [chemical binding]; other site 526225004316 subunit interaction site [polypeptide binding]; other site 526225004317 PHB binding site; other site 526225004318 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 526225004319 Part of AAA domain; Region: AAA_19; pfam13245 526225004320 Family description; Region: UvrD_C_2; pfam13538 526225004321 Methyltransferase domain; Region: Methyltransf_31; pfam13847 526225004322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225004323 S-adenosylmethionine binding site [chemical binding]; other site 526225004324 cytokinin dehydrogenase; Region: PLN02441 526225004325 FAD binding domain; Region: FAD_binding_4; pfam01565 526225004326 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 526225004327 O-methyltransferase; Region: Methyltransf_2; pfam00891 526225004328 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 526225004329 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225004330 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225004331 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526225004332 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 526225004333 tetramer interface [polypeptide binding]; other site 526225004334 catalytic Zn binding site [ion binding]; other site 526225004335 NADP binding site [chemical binding]; other site 526225004336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225004337 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 526225004338 NAD(P) binding site [chemical binding]; other site 526225004339 active site 526225004340 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 526225004341 hypothetical protein; Validated; Region: PRK07581 526225004342 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 526225004343 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 526225004344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225004345 EthD domain; Region: EthD; cl17553 526225004346 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 526225004347 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 526225004348 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 526225004349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 526225004350 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 526225004351 putative hydrophobic ligand binding site [chemical binding]; other site 526225004352 protein interface [polypeptide binding]; other site 526225004353 gate; other site 526225004354 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225004355 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225004356 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225004357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225004358 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225004359 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 526225004360 active site 2 [active] 526225004361 active site 1 [active] 526225004362 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 526225004363 NAD(P) binding site [chemical binding]; other site 526225004364 Enoylreductase; Region: PKS_ER; smart00829 526225004365 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526225004366 MULE transposase domain; Region: MULE; pfam10551 526225004367 Lsr2; Region: Lsr2; pfam11774 526225004368 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 526225004369 Prostaglandin dehydrogenases; Region: PGDH; cd05288 526225004370 NAD(P) binding site [chemical binding]; other site 526225004371 substrate binding site [chemical binding]; other site 526225004372 dimer interface [polypeptide binding]; other site 526225004373 TIR domain; Region: TIR_2; pfam13676 526225004374 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225004375 active site 526225004376 Int/Topo IB signature motif; other site 526225004377 DNA binding site [nucleotide binding] 526225004378 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 526225004379 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 526225004380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225004381 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526225004382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225004383 DNA binding residues [nucleotide binding] 526225004384 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 526225004385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 526225004386 nucleotide binding site [chemical binding]; other site 526225004387 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 526225004388 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 526225004389 active site 526225004390 dimerization interface [polypeptide binding]; other site 526225004391 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 526225004392 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 526225004393 putative active site [active] 526225004394 putative substrate binding site [chemical binding]; other site 526225004395 ATP binding site [chemical binding]; other site 526225004396 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 526225004397 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 526225004398 trimer interface [polypeptide binding]; other site 526225004399 active site 526225004400 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 526225004401 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 526225004402 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225004403 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 526225004404 generic binding surface II; other site 526225004405 ssDNA binding site; other site 526225004406 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 526225004407 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 526225004408 TrkA-N domain; Region: TrkA_N; pfam02254 526225004409 TrkA-C domain; Region: TrkA_C; pfam02080 526225004410 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 526225004411 TrkA-N domain; Region: TrkA_N; pfam02254 526225004412 TrkA-C domain; Region: TrkA_C; pfam02080 526225004413 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 526225004414 TRAM domain; Region: TRAM; pfam01938 526225004415 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 526225004416 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 526225004417 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 526225004418 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 526225004419 TPP-binding site; other site 526225004420 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526225004421 PYR/PP interface [polypeptide binding]; other site 526225004422 dimer interface [polypeptide binding]; other site 526225004423 TPP binding site [chemical binding]; other site 526225004424 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526225004425 Domain of unknown function DUF77; Region: DUF77; pfam01910 526225004426 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225004427 fatty oxidation complex, alpha subunit FadJ; Region: FadJ; TIGR02440 526225004428 substrate binding site [chemical binding]; other site 526225004429 oxyanion hole (OAH) forming residues; other site 526225004430 trimer interface [polypeptide binding]; other site 526225004431 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 526225004432 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526225004433 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526225004434 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 526225004435 dimer interface [polypeptide binding]; other site 526225004436 active site 526225004437 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 526225004438 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 526225004439 catalytic site [active] 526225004440 putative active site [active] 526225004441 putative substrate binding site [chemical binding]; other site 526225004442 Helicase and RNase D C-terminal; Region: HRDC; smart00341 526225004443 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 526225004444 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 526225004445 substrate binding site [chemical binding]; other site 526225004446 active site 526225004447 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 526225004448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225004449 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 526225004450 methionine sulfoxide reductase B; Provisional; Region: PRK00222 526225004451 SelR domain; Region: SelR; pfam01641 526225004452 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526225004453 DNA-binding site [nucleotide binding]; DNA binding site 526225004454 RNA-binding motif; other site 526225004455 YCII-related domain; Region: YCII; cl00999 526225004456 Predicted membrane protein [Function unknown]; Region: COG2261 526225004457 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526225004458 active site 526225004459 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 526225004460 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 526225004461 FAD binding pocket [chemical binding]; other site 526225004462 FAD binding motif [chemical binding]; other site 526225004463 phosphate binding motif [ion binding]; other site 526225004464 beta-alpha-beta structure motif; other site 526225004465 NAD(p) ribose binding residues [chemical binding]; other site 526225004466 NAD binding pocket [chemical binding]; other site 526225004467 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 526225004468 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225004469 catalytic loop [active] 526225004470 iron binding site [ion binding]; other site 526225004471 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 526225004472 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 526225004473 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 526225004474 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 526225004475 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 526225004476 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 526225004477 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 526225004478 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225004479 acyl-activating enzyme (AAE) consensus motif; other site 526225004480 AMP binding site [chemical binding]; other site 526225004481 active site 526225004482 CoA binding site [chemical binding]; other site 526225004483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225004484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225004485 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 526225004486 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 526225004487 substrate binding site [chemical binding]; other site 526225004488 dimer interface [polypeptide binding]; other site 526225004489 NADP binding site [chemical binding]; other site 526225004490 catalytic residues [active] 526225004491 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 526225004492 active site 2 [active] 526225004493 active site 1 [active] 526225004494 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225004495 Cytochrome P450; Region: p450; cl12078 526225004496 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 526225004497 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 526225004498 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526225004499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225004500 metabolite-proton symporter; Region: 2A0106; TIGR00883 526225004501 putative substrate translocation pore; other site 526225004502 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225004503 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 526225004504 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225004505 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526225004506 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 526225004507 NAD(P) binding site [chemical binding]; other site 526225004508 catalytic residues [active] 526225004509 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 526225004510 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 526225004511 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 526225004512 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 526225004513 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 526225004514 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225004515 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526225004516 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225004517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225004518 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 526225004519 Amino acid permease; Region: AA_permease; pfam00324 526225004520 tyramine oxidase; Provisional; Region: tynA; PRK11504 526225004521 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 526225004522 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 526225004523 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 526225004524 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 526225004525 putative DNA binding site [nucleotide binding]; other site 526225004526 putative Zn2+ binding site [ion binding]; other site 526225004527 AsnC family; Region: AsnC_trans_reg; pfam01037 526225004528 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 526225004529 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 526225004530 dimer interface [polypeptide binding]; other site 526225004531 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 526225004532 active site 526225004533 Fe binding site [ion binding]; other site 526225004534 Uncharacterized conserved protein [Function unknown]; Region: COG2966 526225004535 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 526225004536 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 526225004537 hypothetical protein; Provisional; Region: PRK06541 526225004538 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526225004539 inhibitor-cofactor binding pocket; inhibition site 526225004540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225004541 catalytic residue [active] 526225004542 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 526225004543 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 526225004544 hexamer interface [polypeptide binding]; other site 526225004545 ligand binding site [chemical binding]; other site 526225004546 putative active site [active] 526225004547 NAD(P) binding site [chemical binding]; other site 526225004548 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 526225004549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225004550 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526225004551 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 526225004552 NAD(P) binding site [chemical binding]; other site 526225004553 catalytic residues [active] 526225004554 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526225004555 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 526225004556 aldehyde dehydrogenase family 7 member; Region: PLN02315 526225004557 tetrameric interface [polypeptide binding]; other site 526225004558 NAD binding site [chemical binding]; other site 526225004559 catalytic residues [active] 526225004560 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 526225004561 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 526225004562 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 526225004563 nucleotide binding site [chemical binding]; other site 526225004564 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225004565 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 526225004566 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 526225004567 active site 526225004568 DNA binding site [nucleotide binding] 526225004569 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 526225004570 DNA binding site [nucleotide binding] 526225004571 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 526225004572 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 526225004573 putative active site [active] 526225004574 hypothetical protein; Provisional; Region: PRK14059 526225004575 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 526225004576 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 526225004577 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 526225004578 catalytic site [active] 526225004579 active site 526225004580 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526225004581 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 526225004582 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526225004583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225004584 Walker A/P-loop; other site 526225004585 ATP binding site [chemical binding]; other site 526225004586 Q-loop/lid; other site 526225004587 ABC transporter signature motif; other site 526225004588 Walker B; other site 526225004589 D-loop; other site 526225004590 H-loop/switch region; other site 526225004591 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 526225004592 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 526225004593 FtsX-like permease family; Region: FtsX; pfam02687 526225004594 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 526225004595 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526225004596 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 526225004597 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 526225004598 active site 526225004599 catalytic site [active] 526225004600 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 526225004601 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 526225004602 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 526225004603 active site 526225004604 catalytic site [active] 526225004605 excinuclease ABC subunit B; Provisional; Region: PRK05298 526225004606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225004607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225004608 nucleotide binding region [chemical binding]; other site 526225004609 ATP-binding site [chemical binding]; other site 526225004610 Ultra-violet resistance protein B; Region: UvrB; pfam12344 526225004611 UvrB/uvrC motif; Region: UVR; pfam02151 526225004612 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 526225004613 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 526225004614 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 526225004615 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 526225004616 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225004617 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 526225004618 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526225004619 classical (c) SDRs; Region: SDR_c; cd05233 526225004620 NAD(P) binding site [chemical binding]; other site 526225004621 active site 526225004622 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 526225004623 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526225004624 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526225004625 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 526225004626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225004627 NAD(P) binding site [chemical binding]; other site 526225004628 active site 526225004629 CAAX protease self-immunity; Region: Abi; pfam02517 526225004630 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 526225004631 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 526225004632 catalytic residues [active] 526225004633 catalytic nucleophile [active] 526225004634 Recombinase; Region: Recombinase; pfam07508 526225004635 CHC2 zinc finger; Region: zf-CHC2; cl17510 526225004636 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 526225004637 active site 526225004638 metal binding site [ion binding]; metal-binding site 526225004639 interdomain interaction site; other site 526225004640 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 526225004641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225004642 non-specific DNA binding site [nucleotide binding]; other site 526225004643 salt bridge; other site 526225004644 sequence-specific DNA binding site [nucleotide binding]; other site 526225004645 Histidine kinase; Region: HisKA_3; pfam07730 526225004646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225004647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225004648 active site 526225004649 phosphorylation site [posttranslational modification] 526225004650 intermolecular recognition site; other site 526225004651 dimerization interface [polypeptide binding]; other site 526225004652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225004653 DNA binding residues [nucleotide binding] 526225004654 dimerization interface [polypeptide binding]; other site 526225004655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225004656 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225004657 putative substrate translocation pore; other site 526225004658 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 526225004659 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225004660 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526225004661 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 526225004662 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 526225004663 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 526225004664 cyclase homology domain; Region: CHD; cd07302 526225004665 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 526225004666 nucleotidyl binding site; other site 526225004667 metal binding site [ion binding]; metal-binding site 526225004668 dimer interface [polypeptide binding]; other site 526225004669 Predicted ATPase [General function prediction only]; Region: COG3903 526225004670 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 526225004671 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 526225004672 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 526225004673 cyclase homology domain; Region: CHD; cd07302 526225004674 dimer interface [polypeptide binding]; other site 526225004675 Predicted ATPase [General function prediction only]; Region: COG3903 526225004676 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225004677 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 526225004678 putative NAD(P) binding site [chemical binding]; other site 526225004679 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 526225004680 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 526225004681 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225004682 DDE superfamily endonuclease; Region: DDE_4; cl17710 526225004683 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225004684 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 526225004685 DoxX-like family; Region: DoxX_2; pfam13564 526225004686 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 526225004687 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225004688 active site 526225004689 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 526225004690 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 526225004691 putative active site [active] 526225004692 metal binding site [ion binding]; metal-binding site 526225004693 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 526225004694 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 526225004695 NADP binding site [chemical binding]; other site 526225004696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225004697 Histidine kinase; Region: HisKA_3; pfam07730 526225004698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225004699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225004700 active site 526225004701 phosphorylation site [posttranslational modification] 526225004702 intermolecular recognition site; other site 526225004703 dimerization interface [polypeptide binding]; other site 526225004704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225004705 DNA binding residues [nucleotide binding] 526225004706 dimerization interface [polypeptide binding]; other site 526225004707 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225004708 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 526225004709 Walker A/P-loop; other site 526225004710 ATP binding site [chemical binding]; other site 526225004711 Q-loop/lid; other site 526225004712 ABC transporter signature motif; other site 526225004713 Walker B; other site 526225004714 D-loop; other site 526225004715 H-loop/switch region; other site 526225004716 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225004717 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 526225004718 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 526225004719 Int/Topo IB signature motif; other site 526225004720 Helix-turn-helix domain; Region: HTH_17; pfam12728 526225004721 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 526225004722 AAA domain; Region: AAA_30; pfam13604 526225004723 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 526225004724 intersubunit interface [polypeptide binding]; other site 526225004725 active site 526225004726 Zn2+ binding site [ion binding]; other site 526225004727 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 526225004728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225004729 DNA-binding site [nucleotide binding]; DNA binding site 526225004730 UTRA domain; Region: UTRA; pfam07702 526225004731 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 526225004732 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 526225004733 ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326 526225004734 dimer interface [polypeptide binding]; other site 526225004735 active site 526225004736 catalytic residue [active] 526225004737 metal binding site [ion binding]; metal-binding site 526225004738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 526225004739 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225004740 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 526225004741 NAD(P) binding site [chemical binding]; other site 526225004742 Transposase; Region: DEDD_Tnp_IS110; pfam01548 526225004743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 526225004744 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 526225004745 RibD C-terminal domain; Region: RibD_C; cl17279 526225004746 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225004747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225004748 active site 526225004749 metal binding site [ion binding]; metal-binding site 526225004750 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 526225004751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225004752 amidase; Provisional; Region: PRK12470 526225004753 Amidase; Region: Amidase; cl11426 526225004754 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 526225004755 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 526225004756 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 526225004757 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 526225004758 Uncharacterized conserved protein [Function unknown]; Region: COG3268 526225004759 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 526225004760 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225004761 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225004762 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 526225004763 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 526225004764 GIY-YIG motif/motif A; other site 526225004765 active site 526225004766 catalytic site [active] 526225004767 putative DNA binding site [nucleotide binding]; other site 526225004768 metal binding site [ion binding]; metal-binding site 526225004769 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 526225004770 Helix-hairpin-helix motif; Region: HHH; pfam00633 526225004771 helix-hairpin-helix signature motif; other site 526225004772 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 526225004773 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 526225004774 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 526225004775 putative substrate binding pocket [chemical binding]; other site 526225004776 dimer interface [polypeptide binding]; other site 526225004777 phosphate binding site [ion binding]; other site 526225004778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 526225004779 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 526225004780 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 526225004781 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 526225004782 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 526225004783 Phosphoglycerate kinase; Region: PGK; pfam00162 526225004784 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 526225004785 substrate binding site [chemical binding]; other site 526225004786 hinge regions; other site 526225004787 ADP binding site [chemical binding]; other site 526225004788 catalytic site [active] 526225004789 triosephosphate isomerase; Provisional; Region: PRK14567 526225004790 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 526225004791 substrate binding site [chemical binding]; other site 526225004792 dimer interface [polypeptide binding]; other site 526225004793 catalytic triad [active] 526225004794 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 526225004795 peptide binding site [polypeptide binding]; other site 526225004796 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 526225004797 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 526225004798 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 526225004799 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 526225004800 putative active site [active] 526225004801 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 526225004802 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 526225004803 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 526225004804 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 526225004805 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 526225004806 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 526225004807 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 526225004808 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 526225004809 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 526225004810 putative active site [active] 526225004811 transaldolase; Provisional; Region: PRK03903 526225004812 catalytic residue [active] 526225004813 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 526225004814 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 526225004815 TPP-binding site [chemical binding]; other site 526225004816 dimer interface [polypeptide binding]; other site 526225004817 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 526225004818 PYR/PP interface [polypeptide binding]; other site 526225004819 dimer interface [polypeptide binding]; other site 526225004820 TPP binding site [chemical binding]; other site 526225004821 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526225004822 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 526225004823 UbiA prenyltransferase family; Region: UbiA; pfam01040 526225004824 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 526225004825 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 526225004826 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 526225004827 Clp amino terminal domain; Region: Clp_N; pfam02861 526225004828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225004829 Walker A motif; other site 526225004830 ATP binding site [chemical binding]; other site 526225004831 Walker B motif; other site 526225004832 arginine finger; other site 526225004833 UvrB/uvrC motif; Region: UVR; pfam02151 526225004834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225004835 Walker A motif; other site 526225004836 ATP binding site [chemical binding]; other site 526225004837 Walker B motif; other site 526225004838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 526225004839 Predicted transcriptional regulator [Transcription]; Region: COG2345 526225004840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225004841 putative DNA binding site [nucleotide binding]; other site 526225004842 putative Zn2+ binding site [ion binding]; other site 526225004843 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 526225004844 FeS assembly protein SufB; Region: sufB; TIGR01980 526225004845 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 526225004846 FeS assembly protein SufD; Region: sufD; TIGR01981 526225004847 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 526225004848 [2Fe-2S] cluster binding site [ion binding]; other site 526225004849 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 526225004850 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 526225004851 Walker A/P-loop; other site 526225004852 ATP binding site [chemical binding]; other site 526225004853 Q-loop/lid; other site 526225004854 ABC transporter signature motif; other site 526225004855 Walker B; other site 526225004856 D-loop; other site 526225004857 H-loop/switch region; other site 526225004858 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526225004859 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 526225004860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225004861 catalytic residue [active] 526225004862 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 526225004863 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 526225004864 trimerization site [polypeptide binding]; other site 526225004865 active site 526225004866 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 526225004867 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526225004868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225004869 Walker A/P-loop; other site 526225004870 ATP binding site [chemical binding]; other site 526225004871 Q-loop/lid; other site 526225004872 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225004873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225004874 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526225004875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225004876 substrate binding site [chemical binding]; other site 526225004877 oxyanion hole (OAH) forming residues; other site 526225004878 trimer interface [polypeptide binding]; other site 526225004879 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526225004880 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526225004881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225004882 Walker A/P-loop; other site 526225004883 ATP binding site [chemical binding]; other site 526225004884 Q-loop/lid; other site 526225004885 ABC transporter signature motif; other site 526225004886 Walker B; other site 526225004887 D-loop; other site 526225004888 H-loop/switch region; other site 526225004889 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 526225004890 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 526225004891 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 526225004892 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 526225004893 putative active site [active] 526225004894 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 526225004895 active site 526225004896 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 526225004897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225004898 NAD(P) binding site [chemical binding]; other site 526225004899 active site 526225004900 aconitate hydratase; Provisional; Region: acnA; PRK12881 526225004901 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 526225004902 substrate binding site [chemical binding]; other site 526225004903 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 526225004904 ligand binding site [chemical binding]; other site 526225004905 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 526225004906 substrate binding site [chemical binding]; other site 526225004907 NAD-dependent deacetylase; Provisional; Region: PRK00481 526225004908 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 526225004909 NAD+ binding site [chemical binding]; other site 526225004910 substrate binding site [chemical binding]; other site 526225004911 Zn binding site [ion binding]; other site 526225004912 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 526225004913 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225004914 acyl-activating enzyme (AAE) consensus motif; other site 526225004915 AMP binding site [chemical binding]; other site 526225004916 active site 526225004917 CoA binding site [chemical binding]; other site 526225004918 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 526225004919 NlpC/P60 family; Region: NLPC_P60; pfam00877 526225004920 MoxR-like ATPases [General function prediction only]; Region: COG0714 526225004921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225004922 Walker A motif; other site 526225004923 ATP binding site [chemical binding]; other site 526225004924 Walker B motif; other site 526225004925 arginine finger; other site 526225004926 Protein of unknown function DUF58; Region: DUF58; pfam01882 526225004927 hypothetical protein; Provisional; Region: PRK13685 526225004928 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526225004929 metal ion-dependent adhesion site (MIDAS); other site 526225004930 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225004931 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 526225004932 DXD motif; other site 526225004933 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 526225004934 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 526225004935 Amidase; Region: Amidase; pfam01425 526225004936 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 526225004937 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 526225004938 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 526225004939 short chain dehydrogenase; Provisional; Region: PRK06180 526225004940 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 526225004941 NADP binding site [chemical binding]; other site 526225004942 active site 526225004943 steroid binding site; other site 526225004944 short chain dehydrogenase; Validated; Region: PRK08324 526225004945 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 526225004946 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 526225004947 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526225004948 catalytic Zn binding site [ion binding]; other site 526225004949 NAD(P) binding site [chemical binding]; other site 526225004950 structural Zn binding site [ion binding]; other site 526225004951 Helix-turn-helix domain; Region: HTH_31; pfam13560 526225004952 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 526225004953 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 526225004954 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225004955 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225004956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225004957 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 526225004958 NAD(P) binding site [chemical binding]; other site 526225004959 active site 526225004960 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 526225004961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225004962 NAD(P) binding site [chemical binding]; other site 526225004963 active site 526225004964 ferrochelatase; Reviewed; Region: hemH; PRK00035 526225004965 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 526225004966 C-terminal domain interface [polypeptide binding]; other site 526225004967 active site 526225004968 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 526225004969 active site 526225004970 N-terminal domain interface [polypeptide binding]; other site 526225004971 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225004972 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 526225004973 catalytic site [active] 526225004974 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 526225004975 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 526225004976 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 526225004977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225004978 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 526225004979 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526225004980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225004981 DNA binding residues [nucleotide binding] 526225004982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 526225004983 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225004984 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225004985 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225004986 anti sigma factor interaction site; other site 526225004987 regulatory phosphorylation site [posttranslational modification]; other site 526225004988 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 526225004989 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 526225004990 active site 526225004991 DNA binding site [nucleotide binding] 526225004992 Int/Topo IB signature motif; other site 526225004993 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225004994 anti sigma factor interaction site; other site 526225004995 regulatory phosphorylation site [posttranslational modification]; other site 526225004996 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 526225004997 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 526225004998 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 526225004999 putative DNA binding site [nucleotide binding]; other site 526225005000 putative homodimer interface [polypeptide binding]; other site 526225005001 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 526225005002 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 526225005003 active site 526225005004 DNA binding site [nucleotide binding] 526225005005 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 526225005006 DNA binding site [nucleotide binding] 526225005007 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 526225005008 nucleotide binding site [chemical binding]; other site 526225005009 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 526225005010 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 526225005011 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 526225005012 putative active site [active] 526225005013 putative substrate binding site [chemical binding]; other site 526225005014 putative cosubstrate binding site; other site 526225005015 catalytic site [active] 526225005016 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225005017 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225005018 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225005019 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526225005020 metal binding site 2 [ion binding]; metal-binding site 526225005021 putative DNA binding helix; other site 526225005022 metal binding site 1 [ion binding]; metal-binding site 526225005023 dimer interface [polypeptide binding]; other site 526225005024 structural Zn2+ binding site [ion binding]; other site 526225005025 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 526225005026 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 526225005027 tetramer interface [polypeptide binding]; other site 526225005028 heme binding pocket [chemical binding]; other site 526225005029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225005030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005032 PAC2 family; Region: PAC2; pfam09754 526225005033 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 526225005034 Domain of unknown function DUF20; Region: UPF0118; pfam01594 526225005035 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 526225005036 Dienelactone hydrolase family; Region: DLH; pfam01738 526225005037 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 526225005038 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 526225005039 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 526225005040 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 526225005041 AAA domain; Region: AAA_33; pfam13671 526225005042 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 526225005043 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 526225005044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225005045 NAD(P) binding site [chemical binding]; other site 526225005046 active site 526225005047 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 526225005048 active site 526225005049 catalytic triad [active] 526225005050 oxyanion hole [active] 526225005051 CHAT domain; Region: CHAT; pfam12770 526225005052 Uncharacterized conserved protein [Function unknown]; Region: COG3391 526225005053 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526225005054 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 526225005055 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 526225005056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 526225005057 GAF domain; Region: GAF; pfam01590 526225005058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225005059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225005060 active site 526225005061 phosphorylation site [posttranslational modification] 526225005062 intermolecular recognition site; other site 526225005063 dimerization interface [polypeptide binding]; other site 526225005064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225005065 DNA binding residues [nucleotide binding] 526225005066 dimerization interface [polypeptide binding]; other site 526225005067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225005068 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 526225005069 Mg2+ binding site [ion binding]; other site 526225005070 G-X-G motif; other site 526225005071 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 526225005072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005073 putative substrate translocation pore; other site 526225005074 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 526225005075 N- and C-terminal domain interface [polypeptide binding]; other site 526225005076 active site 526225005077 catalytic site [active] 526225005078 metal binding site [ion binding]; metal-binding site 526225005079 carbohydrate binding site [chemical binding]; other site 526225005080 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 526225005081 ATP binding site [chemical binding]; other site 526225005082 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 526225005083 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 526225005084 active site 526225005085 FMN binding site [chemical binding]; other site 526225005086 substrate binding site [chemical binding]; other site 526225005087 3Fe-4S cluster binding site [ion binding]; other site 526225005088 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 526225005089 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 526225005090 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 526225005091 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 526225005092 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 526225005093 N-acetyl-D-glucosamine binding site [chemical binding]; other site 526225005094 catalytic residue [active] 526225005095 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 526225005096 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 526225005097 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 526225005098 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 526225005099 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 526225005100 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 526225005101 hypothetical protein; Provisional; Region: PRK02237 526225005102 Predicted methyltransferase [General function prediction only]; Region: COG3897 526225005103 Protein of unknown function DUF72; Region: DUF72; pfam01904 526225005104 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225005105 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225005106 active site 526225005107 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 526225005108 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 526225005109 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 526225005110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 526225005111 GXWXG protein; Region: GXWXG; pfam14231 526225005112 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 526225005113 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 526225005114 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 526225005115 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 526225005116 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 526225005117 ligand binding site [chemical binding]; other site 526225005118 homodimer interface [polypeptide binding]; other site 526225005119 NAD(P) binding site [chemical binding]; other site 526225005120 trimer interface B [polypeptide binding]; other site 526225005121 trimer interface A [polypeptide binding]; other site 526225005122 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 526225005123 PAS domain; Region: PAS_9; pfam13426 526225005124 PAS domain S-box; Region: sensory_box; TIGR00229 526225005125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225005126 putative active site [active] 526225005127 heme pocket [chemical binding]; other site 526225005128 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225005129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225005130 metal binding site [ion binding]; metal-binding site 526225005131 active site 526225005132 I-site; other site 526225005133 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225005134 HDOD domain; Region: HDOD; pfam08668 526225005135 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225005136 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225005137 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 526225005138 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 526225005139 active site 526225005140 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 526225005141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225005142 active site 526225005143 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 526225005144 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225005145 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225005146 metal binding site [ion binding]; metal-binding site 526225005147 active site 526225005148 I-site; other site 526225005149 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 526225005150 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225005151 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225005152 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 526225005153 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225005154 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 526225005155 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 526225005156 active site 526225005157 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 526225005158 heterodimer interface [polypeptide binding]; other site 526225005159 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 526225005160 active site 526225005161 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 526225005162 tetramer interface [polypeptide binding]; other site 526225005163 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 526225005164 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526225005165 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 526225005166 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 526225005167 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 526225005168 active site 526225005169 dimer interface [polypeptide binding]; other site 526225005170 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 526225005171 dimer interface [polypeptide binding]; other site 526225005172 active site 526225005173 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526225005174 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 526225005175 NAD(P) binding site [chemical binding]; other site 526225005176 catalytic residues [active] 526225005177 cyanate transporter; Region: CynX; TIGR00896 526225005178 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 526225005179 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 526225005180 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 526225005181 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 526225005182 putative active site [active] 526225005183 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 526225005184 hypothetical protein; Provisional; Region: PRK05463 526225005185 argininosuccinate synthase; Validated; Region: PRK05370 526225005186 RibD C-terminal domain; Region: RibD_C; cl17279 526225005187 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 526225005188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225005189 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 526225005190 putative ADP-binding pocket [chemical binding]; other site 526225005191 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225005192 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225005193 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 526225005194 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225005195 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225005196 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 526225005197 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526225005198 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225005199 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 526225005200 putative NAD(P) binding site [chemical binding]; other site 526225005201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225005202 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 526225005203 Protein of unknown function (DUF664); Region: DUF664; pfam04978 526225005204 Competence protein CoiA-like family; Region: CoiA; cl11541 526225005205 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 526225005206 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 526225005207 active site 526225005208 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225005209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225005210 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 526225005211 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 526225005212 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 526225005213 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225005214 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 526225005215 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 526225005216 NAD(P) binding site [chemical binding]; other site 526225005217 catalytic residues [active] 526225005218 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 526225005219 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225005220 putative NAD(P) binding site [chemical binding]; other site 526225005221 pyridoxamine kinase; Validated; Region: PRK05756 526225005222 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 526225005223 pyridoxal binding site [chemical binding]; other site 526225005224 dimer interface [polypeptide binding]; other site 526225005225 ATP binding site [chemical binding]; other site 526225005226 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 526225005227 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225005228 active site 526225005229 HIGH motif; other site 526225005230 nucleotide binding site [chemical binding]; other site 526225005231 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225005232 active site 526225005233 KMSKS motif; other site 526225005234 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526225005235 active site 526225005236 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 526225005237 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 526225005238 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 526225005239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225005240 Coenzyme A binding pocket [chemical binding]; other site 526225005241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526225005242 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 526225005243 B12 binding site [chemical binding]; other site 526225005244 cobalt ligand [ion binding]; other site 526225005245 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 526225005246 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 526225005247 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 526225005248 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526225005249 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 526225005250 intersubunit interface [polypeptide binding]; other site 526225005251 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 526225005252 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 526225005253 heme-binding site [chemical binding]; other site 526225005254 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 526225005255 FAD binding pocket [chemical binding]; other site 526225005256 FAD binding motif [chemical binding]; other site 526225005257 phosphate binding motif [ion binding]; other site 526225005258 beta-alpha-beta structure motif; other site 526225005259 NAD binding pocket [chemical binding]; other site 526225005260 DivIVA domain; Region: DivI1A_domain; TIGR03544 526225005261 DivIVA protein; Region: DivIVA; pfam05103 526225005262 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 526225005263 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 526225005264 heme-binding site [chemical binding]; other site 526225005265 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 526225005266 FAD binding pocket [chemical binding]; other site 526225005267 FAD binding motif [chemical binding]; other site 526225005268 phosphate binding motif [ion binding]; other site 526225005269 beta-alpha-beta structure motif; other site 526225005270 NAD binding pocket [chemical binding]; other site 526225005271 Heme binding pocket [chemical binding]; other site 526225005272 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225005273 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225005274 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 526225005275 CoA-transferase family III; Region: CoA_transf_3; pfam02515 526225005276 enoyl-CoA hydratase; Provisional; Region: PRK08252 526225005277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225005278 substrate binding site [chemical binding]; other site 526225005279 oxyanion hole (OAH) forming residues; other site 526225005280 trimer interface [polypeptide binding]; other site 526225005281 Uncharacterized conserved protein [Function unknown]; Region: COG2353 526225005282 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 526225005283 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 526225005284 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 526225005285 Chromate transporter; Region: Chromate_transp; pfam02417 526225005286 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 526225005287 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225005288 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225005289 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225005290 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 526225005291 active site 526225005292 catalytic triad [active] 526225005293 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 526225005294 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225005295 anti sigma factor interaction site; other site 526225005296 regulatory phosphorylation site [posttranslational modification]; other site 526225005297 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 526225005298 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 526225005299 NAD binding site [chemical binding]; other site 526225005300 6-phosphofructokinase; Provisional; Region: PRK03202 526225005301 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 526225005302 active site 526225005303 ADP/pyrophosphate binding site [chemical binding]; other site 526225005304 dimerization interface [polypeptide binding]; other site 526225005305 allosteric effector site; other site 526225005306 fructose-1,6-bisphosphate binding site; other site 526225005307 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 526225005308 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526225005309 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225005310 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 526225005311 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 526225005312 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 526225005313 shikimate binding site; other site 526225005314 NAD(P) binding site [chemical binding]; other site 526225005315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005316 metabolite-proton symporter; Region: 2A0106; TIGR00883 526225005317 putative substrate translocation pore; other site 526225005318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225005319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225005320 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 526225005321 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526225005322 catalytic residues [active] 526225005323 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 526225005324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 526225005325 active site 526225005326 phosphorylation site [posttranslational modification] 526225005327 intermolecular recognition site; other site 526225005328 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 526225005329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225005330 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 526225005331 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 526225005332 ligand binding site [chemical binding]; other site 526225005333 flexible hinge region; other site 526225005334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225005335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225005336 ATP binding site [chemical binding]; other site 526225005337 Mg2+ binding site [ion binding]; other site 526225005338 G-X-G motif; other site 526225005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005340 putative substrate translocation pore; other site 526225005341 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 526225005342 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 526225005343 PAS domain; Region: PAS; smart00091 526225005344 PAS fold; Region: PAS; pfam00989 526225005345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225005346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225005347 ATP binding site [chemical binding]; other site 526225005348 G-X-G motif; other site 526225005349 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 526225005350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225005351 active site 526225005352 phosphorylation site [posttranslational modification] 526225005353 intermolecular recognition site; other site 526225005354 dimerization interface [polypeptide binding]; other site 526225005355 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 526225005356 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526225005357 FAD binding domain; Region: FAD_binding_4; pfam01565 526225005358 Berberine and berberine like; Region: BBE; pfam08031 526225005359 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225005360 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 526225005361 catalytic site [active] 526225005362 oxaloacetate decarboxylase; Provisional; Region: PRK14040 526225005363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 526225005364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526225005365 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 526225005366 dimerization interface [polypeptide binding]; other site 526225005367 substrate binding pocket [chemical binding]; other site 526225005368 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 526225005369 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 526225005370 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 526225005371 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 526225005372 trimer interface [polypeptide binding]; other site 526225005373 putative metal binding site [ion binding]; other site 526225005374 ribonuclease Z; Reviewed; Region: PRK00055 526225005375 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 526225005376 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 526225005377 active site 526225005378 SUMO-1 interface [polypeptide binding]; other site 526225005379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526225005380 Predicted transcriptional regulators [Transcription]; Region: COG1733 526225005381 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 526225005382 AzlC protein; Region: AzlC; pfam03591 526225005383 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 526225005384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225005385 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526225005386 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526225005387 DNA-binding site [nucleotide binding]; DNA binding site 526225005388 RNA-binding motif; other site 526225005389 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526225005390 DNA-binding site [nucleotide binding]; DNA binding site 526225005391 RNA-binding motif; other site 526225005392 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526225005393 DNA-binding site [nucleotide binding]; DNA binding site 526225005394 RNA-binding motif; other site 526225005395 YciI-like protein; Reviewed; Region: PRK12866 526225005396 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 526225005397 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225005398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225005399 ATP binding site [chemical binding]; other site 526225005400 Mg2+ binding site [ion binding]; other site 526225005401 G-X-G motif; other site 526225005402 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 526225005403 ATP binding site [chemical binding]; other site 526225005404 putative Mg++ binding site [ion binding]; other site 526225005405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225005406 nucleotide binding region [chemical binding]; other site 526225005407 ATP-binding site [chemical binding]; other site 526225005408 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 526225005409 active site 526225005410 oxyanion hole [active] 526225005411 putative hydrolase; Provisional; Region: PRK11460 526225005412 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526225005413 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 526225005414 Soluble P-type ATPase [General function prediction only]; Region: COG4087 526225005415 Helix-turn-helix domain; Region: HTH_18; pfam12833 526225005416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225005417 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225005418 TIGR03086 family protein; Region: TIGR03086 526225005419 Domain of unknown function (DUF336); Region: DUF336; cl01249 526225005420 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 526225005421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225005422 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 526225005423 Walker A/P-loop; other site 526225005424 ATP binding site [chemical binding]; other site 526225005425 Q-loop/lid; other site 526225005426 ABC transporter signature motif; other site 526225005427 Walker B; other site 526225005428 D-loop; other site 526225005429 H-loop/switch region; other site 526225005430 ABC-2 type transporter; Region: ABC2_membrane; cl17235 526225005431 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526225005432 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 526225005433 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 526225005434 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 526225005435 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225005436 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 526225005437 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 526225005438 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 526225005439 active site 526225005440 catalytic site [active] 526225005441 amidophosphoribosyltransferase; Region: PLN02440 526225005442 CAAX protease self-immunity; Region: Abi; pfam02517 526225005443 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 526225005444 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 526225005445 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225005446 GAF domain; Region: GAF; pfam01590 526225005447 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 526225005448 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 526225005449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225005450 active site 526225005451 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 526225005452 active site 526225005453 ornithine cyclodeaminase; Validated; Region: PRK06141 526225005454 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 526225005455 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 526225005456 Proline racemase; Region: Pro_racemase; pfam05544 526225005457 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 526225005458 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 526225005459 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 526225005460 dimer interface [polypeptide binding]; other site 526225005461 putative anticodon binding site; other site 526225005462 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526225005463 motif 1; other site 526225005464 dimer interface [polypeptide binding]; other site 526225005465 active site 526225005466 motif 2; other site 526225005467 motif 3; other site 526225005468 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 526225005469 Protein of unknown function (DUF461); Region: DUF461; pfam04314 526225005470 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 526225005471 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 526225005472 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 526225005473 active site 526225005474 catalytic site [active] 526225005475 Zn binding site [ion binding]; other site 526225005476 tetramer interface [polypeptide binding]; other site 526225005477 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 526225005478 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 526225005479 active site 526225005480 homotetramer interface [polypeptide binding]; other site 526225005481 homodimer interface [polypeptide binding]; other site 526225005482 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 526225005483 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 526225005484 FAD binding pocket [chemical binding]; other site 526225005485 FAD binding motif [chemical binding]; other site 526225005486 phosphate binding motif [ion binding]; other site 526225005487 beta-alpha-beta structure motif; other site 526225005488 NAD binding pocket [chemical binding]; other site 526225005489 acyl-CoA synthetase; Validated; Region: PRK08162 526225005490 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 526225005491 acyl-activating enzyme (AAE) consensus motif; other site 526225005492 putative active site [active] 526225005493 AMP binding site [chemical binding]; other site 526225005494 putative CoA binding site [chemical binding]; other site 526225005495 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 526225005496 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 526225005497 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 526225005498 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 526225005499 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 526225005500 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 526225005501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225005502 Walker A/P-loop; other site 526225005503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225005504 Walker A/P-loop; other site 526225005505 ATP binding site [chemical binding]; other site 526225005506 ATP binding site [chemical binding]; other site 526225005507 Q-loop/lid; other site 526225005508 ABC transporter signature motif; other site 526225005509 Walker B; other site 526225005510 D-loop; other site 526225005511 RibD C-terminal domain; Region: RibD_C; cl17279 526225005512 RibD C-terminal domain; Region: RibD_C; cl17279 526225005513 Integrase core domain; Region: rve_3; cl15866 526225005514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005515 putative substrate translocation pore; other site 526225005516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225005517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005518 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 526225005519 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 526225005520 glycogen branching enzyme; Provisional; Region: PRK14705 526225005521 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 526225005522 hypothetical protein; Provisional; Region: PRK07236 526225005523 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 526225005524 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 526225005525 active site 526225005526 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 526225005527 DNA binding site [nucleotide binding] 526225005528 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 526225005529 DAK2 domain; Region: Dak2; cl03685 526225005530 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 526225005531 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 526225005532 Protein of unknown function (DUF461); Region: DUF461; cl01071 526225005533 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225005534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225005535 active site 526225005536 phosphorylation site [posttranslational modification] 526225005537 intermolecular recognition site; other site 526225005538 dimerization interface [polypeptide binding]; other site 526225005539 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225005540 DNA binding site [nucleotide binding] 526225005541 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 526225005542 SpoOM protein; Region: Spo0M; pfam07070 526225005543 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225005544 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 526225005545 active site 526225005546 putative substrate binding region [chemical binding]; other site 526225005547 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 526225005548 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 526225005549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225005550 NAD(P) binding site [chemical binding]; other site 526225005551 active site 526225005552 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 526225005553 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526225005554 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225005555 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 526225005556 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 526225005557 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225005558 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 526225005559 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 526225005560 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 526225005561 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225005562 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 526225005563 NAD(P) binding site [chemical binding]; other site 526225005564 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 526225005565 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225005566 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526225005567 Sucrose-6-phosphate phosphohydrolase C-terminal; Region: S6PP_C; pfam08472 526225005568 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 526225005569 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 526225005570 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526225005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225005572 acyl-CoA synthetase; Validated; Region: PRK08316 526225005573 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225005574 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 526225005575 acyl-activating enzyme (AAE) consensus motif; other site 526225005576 putative AMP binding site [chemical binding]; other site 526225005577 putative active site [active] 526225005578 putative CoA binding site [chemical binding]; other site 526225005579 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 526225005580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225005581 acyl-activating enzyme (AAE) consensus motif; other site 526225005582 AMP binding site [chemical binding]; other site 526225005583 active site 526225005584 CoA binding site [chemical binding]; other site 526225005585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225005586 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225005587 active site 526225005588 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 526225005589 E-class dimer interface [polypeptide binding]; other site 526225005590 P-class dimer interface [polypeptide binding]; other site 526225005591 active site 526225005592 Cu2+ binding site [ion binding]; other site 526225005593 Zn2+ binding site [ion binding]; other site 526225005594 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 526225005595 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 526225005596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225005597 acyl-coenzyme A oxidase; Region: PLN02526 526225005598 active site 526225005599 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 526225005600 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526225005601 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225005602 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225005603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225005604 S-adenosylmethionine binding site [chemical binding]; other site 526225005605 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225005606 Cytochrome P450; Region: p450; cl12078 526225005607 hypothetical protein; Provisional; Region: PRK06185 526225005608 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225005609 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225005610 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225005611 Ligand Binding Site [chemical binding]; other site 526225005612 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 526225005613 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 526225005614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 526225005615 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 526225005616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526225005617 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 526225005618 dimerization interface [polypeptide binding]; other site 526225005619 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 526225005620 N-acetylneuraminate lyase; Provisional; Region: PRK04147 526225005621 catalytic residue [active] 526225005622 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 526225005623 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 526225005624 active site 526225005625 tetramer interface [polypeptide binding]; other site 526225005626 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 526225005627 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 526225005628 active site pocket [active] 526225005629 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 526225005630 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 526225005631 dimer interface [polypeptide binding]; other site 526225005632 NADP binding site [chemical binding]; other site 526225005633 catalytic residues [active] 526225005634 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225005635 Membrane transport protein; Region: Mem_trans; cl09117 526225005636 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526225005637 FAD binding domain; Region: FAD_binding_4; pfam01565 526225005638 Berberine and berberine like; Region: BBE; pfam08031 526225005639 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225005640 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225005641 malate:quinone oxidoreductase; Validated; Region: PRK05257 526225005642 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526225005643 FAD binding domain; Region: FAD_binding_4; pfam01565 526225005644 Transcription factor WhiB; Region: Whib; pfam02467 526225005645 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526225005646 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 526225005647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225005648 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 526225005649 Bacterial transcriptional activator domain; Region: BTAD; smart01043 526225005650 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225005651 Cytochrome P450; Region: p450; cl12078 526225005652 Uncharacterized conserved protein [Function unknown]; Region: COG4850 526225005653 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 526225005654 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 526225005655 DNA-binding site [nucleotide binding]; DNA binding site 526225005656 RNA-binding motif; other site 526225005657 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526225005658 catalytic residues [active] 526225005659 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 526225005660 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 526225005661 NAD(P) binding site [chemical binding]; other site 526225005662 homotetramer interface [polypeptide binding]; other site 526225005663 homodimer interface [polypeptide binding]; other site 526225005664 active site 526225005665 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 526225005666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526225005667 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225005668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 526225005669 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526225005670 carboxyltransferase (CT) interaction site; other site 526225005671 biotinylation site [posttranslational modification]; other site 526225005672 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 526225005673 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 526225005674 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 526225005675 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 526225005676 active site 526225005677 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 526225005678 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 526225005679 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 526225005680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225005681 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 526225005682 YCII-related domain; Region: YCII; cl00999 526225005683 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 526225005684 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 526225005685 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 526225005686 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 526225005687 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 526225005688 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225005689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225005690 Mg2+ binding site [ion binding]; other site 526225005691 G-X-G motif; other site 526225005692 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225005693 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 526225005694 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225005695 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 526225005696 active site 526225005697 intersubunit interface [polypeptide binding]; other site 526225005698 catalytic residue [active] 526225005699 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 526225005700 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225005701 phosphate binding site [ion binding]; other site 526225005702 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526225005703 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 526225005704 substrate binding site [chemical binding]; other site 526225005705 ATP binding site [chemical binding]; other site 526225005706 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 526225005707 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 526225005708 inhibitor site; inhibition site 526225005709 active site 526225005710 dimer interface [polypeptide binding]; other site 526225005711 catalytic residue [active] 526225005712 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 526225005713 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 526225005714 ligand binding site [chemical binding]; other site 526225005715 NAD binding site [chemical binding]; other site 526225005716 catalytic site [active] 526225005717 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526225005718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225005719 NAD(P) binding site [chemical binding]; other site 526225005720 active site 526225005721 dihydroxy-acid dehydratase; Validated; Region: PRK06131 526225005722 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225005723 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 526225005724 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225005725 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 526225005726 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 526225005727 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225005728 NAD(P) binding site [chemical binding]; other site 526225005729 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 526225005730 short chain dehydrogenase; Provisional; Region: PRK06138 526225005731 classical (c) SDRs; Region: SDR_c; cd05233 526225005732 NAD(P) binding site [chemical binding]; other site 526225005733 active site 526225005734 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 526225005735 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 526225005736 active site 526225005737 dimer interface [polypeptide binding]; other site 526225005738 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 526225005739 LytTr DNA-binding domain; Region: LytTR; smart00850 526225005740 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 526225005741 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 526225005742 NAD binding site [chemical binding]; other site 526225005743 catalytic Zn binding site [ion binding]; other site 526225005744 structural Zn binding site [ion binding]; other site 526225005745 Actinobacterial PQQ system protein; Region: PQQ_MSMEG_3727; TIGR04339 526225005746 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 526225005747 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 526225005748 Trp docking motif [polypeptide binding]; other site 526225005749 active site 526225005750 PqqA family; Region: PqqA; cl15372 526225005751 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 526225005752 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 526225005753 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 526225005754 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 526225005755 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 526225005756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225005757 FeS/SAM binding site; other site 526225005758 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 526225005759 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 526225005760 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 526225005761 Domain of unknown function (DUF336); Region: DUF336; pfam03928 526225005762 amino acid transporter; Region: 2A0306; TIGR00909 526225005763 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225005764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225005765 NAD(P) binding site [chemical binding]; other site 526225005766 active site 526225005767 haloalkane dehalogenase; Provisional; Region: PRK03592 526225005768 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225005769 peptide synthase; Provisional; Region: PRK09274 526225005770 acyl-activating enzyme (AAE) consensus motif; other site 526225005771 AMP binding site [chemical binding]; other site 526225005772 active site 526225005773 CoA binding site [chemical binding]; other site 526225005774 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 526225005775 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 526225005776 active site 526225005777 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 526225005778 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225005779 active site 526225005780 DNA binding site [nucleotide binding] 526225005781 Int/Topo IB signature motif; other site 526225005782 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225005783 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 526225005784 Methyltransferase domain; Region: Methyltransf_24; pfam13578 526225005785 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 526225005786 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 526225005787 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 526225005788 ligand binding site [chemical binding]; other site 526225005789 NAD binding site [chemical binding]; other site 526225005790 tetramer interface [polypeptide binding]; other site 526225005791 catalytic site [active] 526225005792 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 526225005793 L-serine binding site [chemical binding]; other site 526225005794 ACT domain interface; other site 526225005795 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 526225005796 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 526225005797 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 526225005798 active site 526225005799 catalytic site [active] 526225005800 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225005801 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 526225005802 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225005803 active site 526225005804 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 526225005805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225005806 Coenzyme A binding pocket [chemical binding]; other site 526225005807 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 526225005808 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526225005809 substrate binding pocket [chemical binding]; other site 526225005810 membrane-bound complex binding site; other site 526225005811 hinge residues; other site 526225005812 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 526225005813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225005814 dimer interface [polypeptide binding]; other site 526225005815 conserved gate region; other site 526225005816 ABC-ATPase subunit interface; other site 526225005817 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 526225005818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225005819 putative PBP binding loops; other site 526225005820 ABC-ATPase subunit interface; other site 526225005821 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 526225005822 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 526225005823 Walker A/P-loop; other site 526225005824 ATP binding site [chemical binding]; other site 526225005825 Q-loop/lid; other site 526225005826 ABC transporter signature motif; other site 526225005827 Walker B; other site 526225005828 D-loop; other site 526225005829 H-loop/switch region; other site 526225005830 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 526225005831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225005832 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 526225005833 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225005834 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 526225005835 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 526225005836 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 526225005837 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225005838 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225005839 DNA binding residues [nucleotide binding] 526225005840 dimerization interface [polypeptide binding]; other site 526225005841 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 526225005842 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 526225005843 active site 526225005844 Zn binding site [ion binding]; other site 526225005845 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 526225005846 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 526225005847 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 526225005848 nucleophile elbow; other site 526225005849 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 526225005850 putative acyl-acceptor binding pocket; other site 526225005851 GYD domain; Region: GYD; pfam08734 526225005852 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 526225005853 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225005854 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 526225005855 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 526225005856 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225005857 Cytochrome P450; Region: p450; cl12078 526225005858 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526225005859 active site 526225005860 catalytic residues [active] 526225005861 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 526225005862 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 526225005863 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 526225005864 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 526225005865 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 526225005866 alpha-dioxygenase; Region: PLN02283 526225005867 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 526225005868 putative heme binding site [chemical binding]; other site 526225005869 putative active site [active] 526225005870 putative substrate binding site [chemical binding]; other site 526225005871 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 526225005872 active site 526225005873 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 526225005874 active site 526225005875 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 526225005876 active site 526225005877 Zn binding site [ion binding]; other site 526225005878 Ferritin-like; Region: Ferritin-like; pfam12902 526225005879 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 526225005880 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 526225005881 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 526225005882 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225005883 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 526225005884 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 526225005885 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 526225005886 hypothetical protein; Validated; Region: PRK06201 526225005887 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 526225005888 enoyl-CoA hydratase; Provisional; Region: PRK06688 526225005889 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225005890 substrate binding site [chemical binding]; other site 526225005891 oxyanion hole (OAH) forming residues; other site 526225005892 trimer interface [polypeptide binding]; other site 526225005893 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225005894 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225005895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225005896 NAD(P) binding site [chemical binding]; other site 526225005897 active site 526225005898 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 526225005899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005900 putative substrate translocation pore; other site 526225005901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005902 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 526225005903 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225005904 DNA binding residues [nucleotide binding] 526225005905 drug binding residues [chemical binding]; other site 526225005906 dimer interface [polypeptide binding]; other site 526225005907 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 526225005908 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 526225005909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225005910 nucleophilic elbow; other site 526225005911 catalytic triad; other site 526225005912 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225005913 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225005914 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225005915 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225005916 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 526225005917 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 526225005918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225005919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225005920 ATP binding site [chemical binding]; other site 526225005921 Mg2+ binding site [ion binding]; other site 526225005922 G-X-G motif; other site 526225005923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225005924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225005925 active site 526225005926 phosphorylation site [posttranslational modification] 526225005927 intermolecular recognition site; other site 526225005928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225005929 DNA binding residues [nucleotide binding] 526225005930 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225005931 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 526225005932 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 526225005933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225005934 ATP binding site [chemical binding]; other site 526225005935 putative Mg++ binding site [ion binding]; other site 526225005936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225005937 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 526225005938 nucleotide binding region [chemical binding]; other site 526225005939 ATP-binding site [chemical binding]; other site 526225005940 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225005941 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225005942 active site 526225005943 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 526225005944 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225005945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225005946 ATP binding site [chemical binding]; other site 526225005947 Mg2+ binding site [ion binding]; other site 526225005948 G-X-G motif; other site 526225005949 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 526225005950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225005951 FeS/SAM binding site; other site 526225005952 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 526225005953 putative ligand binding pocket/active site [active] 526225005954 putative metal binding site [ion binding]; other site 526225005955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526225005956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005957 putative substrate translocation pore; other site 526225005958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225005959 CsbD-like; Region: CsbD; pfam05532 526225005960 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 526225005961 FAD binding domain; Region: FAD_binding_4; pfam01565 526225005962 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 526225005963 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 526225005964 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 526225005965 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 526225005966 DNA binding site [nucleotide binding] 526225005967 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 526225005968 Predicted ATPase [General function prediction only]; Region: COG3903 526225005969 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526225005970 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 526225005971 CoenzymeA binding site [chemical binding]; other site 526225005972 subunit interaction site [polypeptide binding]; other site 526225005973 PHB binding site; other site 526225005974 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 526225005975 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 526225005976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225005977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225005978 DNA binding residues [nucleotide binding] 526225005979 dimerization interface [polypeptide binding]; other site 526225005980 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 526225005981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225005982 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225005983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225005984 NAD(P) binding site [chemical binding]; other site 526225005985 active site 526225005986 hypothetical protein; Provisional; Region: PRK08244 526225005987 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225005988 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225005989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225005990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225005991 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225005992 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 526225005993 Integrase core domain; Region: rve; pfam00665 526225005994 Integrase core domain; Region: rve_2; pfam13333 526225005995 Transposase; Region: HTH_Tnp_1; cl17663 526225005996 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 526225005997 Transposase; Region: DEDD_Tnp_IS110; pfam01548 526225005998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 526225005999 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 526225006000 DDE superfamily endonuclease; Region: DDE_5; pfam13546 526225006001 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225006002 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225006003 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225006004 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 526225006005 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225006006 DDE superfamily endonuclease; Region: DDE_4; pfam13359 526225006007 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225006008 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225006009 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526225006010 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225006011 Winged helix-turn helix; Region: HTH_29; pfam13551 526225006012 Homeodomain-like domain; Region: HTH_32; pfam13565 526225006013 Winged helix-turn helix; Region: HTH_33; pfam13592 526225006014 DDE superfamily endonuclease; Region: DDE_3; pfam13358 526225006015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 526225006016 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 526225006017 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 526225006018 dimer interface [polypeptide binding]; other site 526225006019 substrate binding site [chemical binding]; other site 526225006020 metal binding sites [ion binding]; metal-binding site 526225006021 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225006022 anti sigma factor interaction site; other site 526225006023 regulatory phosphorylation site [posttranslational modification]; other site 526225006024 Epoxide hydrolase N terminus; Region: EHN; pfam06441 526225006025 Dodecin; Region: Dodecin; pfam07311 526225006026 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 526225006027 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 526225006028 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 526225006029 putative active site [active] 526225006030 putative metal binding site [ion binding]; other site 526225006031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225006032 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 526225006033 PGAP1-like protein; Region: PGAP1; pfam07819 526225006034 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 526225006035 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 526225006036 Transposase; Region: HTH_Tnp_1; cl17663 526225006037 Integrase core domain; Region: rve; pfam00665 526225006038 Integrase core domain; Region: rve_3; pfam13683 526225006039 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 526225006040 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 526225006041 active site 526225006042 catalytic residues [active] 526225006043 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526225006044 MULE transposase domain; Region: MULE; pfam10551 526225006045 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225006046 active site 526225006047 Int/Topo IB signature motif; other site 526225006048 DNA binding site [nucleotide binding] 526225006049 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 526225006050 active site 526225006051 catalytic residues [active] 526225006052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225006053 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526225006054 TM-ABC transporter signature motif; other site 526225006055 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225006056 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526225006057 TM-ABC transporter signature motif; other site 526225006058 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 526225006059 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526225006060 Walker A/P-loop; other site 526225006061 ATP binding site [chemical binding]; other site 526225006062 Q-loop/lid; other site 526225006063 ABC transporter signature motif; other site 526225006064 Walker B; other site 526225006065 D-loop; other site 526225006066 H-loop/switch region; other site 526225006067 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 526225006068 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 526225006069 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 526225006070 ligand binding site [chemical binding]; other site 526225006071 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 526225006072 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526225006073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526225006074 DNA binding site [nucleotide binding] 526225006075 domain linker motif; other site 526225006076 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526225006077 dimerization interface [polypeptide binding]; other site 526225006078 ligand binding site [chemical binding]; other site 526225006079 hypothetical protein; Provisional; Region: PRK07906 526225006080 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 526225006081 putative metal binding site [ion binding]; other site 526225006082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 526225006083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526225006084 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 526225006085 putative dimerization interface [polypeptide binding]; other site 526225006086 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 526225006087 aspartate racemase; Region: asp_race; TIGR00035 526225006088 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 526225006089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225006090 NAD(P) binding site [chemical binding]; other site 526225006091 active site 526225006092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225006093 S-adenosylmethionine binding site [chemical binding]; other site 526225006094 glycosyltransferase, MGT family; Region: MGT; TIGR01426 526225006095 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 526225006096 active site 526225006097 TDP-binding site; other site 526225006098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225006099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225006100 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225006101 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 526225006102 AAA domain; Region: AAA_30; pfam13604 526225006103 AAA domain; Region: AAA_22; pfam13401 526225006104 Family description; Region: UvrD_C_2; pfam13538 526225006105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225006106 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225006107 active site 526225006108 catalytic tetrad [active] 526225006109 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 526225006110 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225006111 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 526225006112 nucleophilic elbow; other site 526225006113 catalytic triad; other site 526225006114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225006115 MarR family; Region: MarR_2; cl17246 526225006116 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225006117 catalytic core [active] 526225006118 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 526225006119 conserved hypothetical protein; Region: TIGR03843 526225006120 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225006121 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225006122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225006123 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 526225006124 active site 526225006125 HIGH motif; other site 526225006126 nucleotide binding site [chemical binding]; other site 526225006127 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225006128 active site 526225006129 KMSKS motif; other site 526225006130 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 526225006131 putative tRNA binding surface [nucleotide binding]; other site 526225006132 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 526225006133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526225006134 Zn2+ binding site [ion binding]; other site 526225006135 Mg2+ binding site [ion binding]; other site 526225006136 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 526225006137 PAC2 family; Region: PAC2; pfam09754 526225006138 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 526225006139 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 526225006140 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 526225006141 substrate binding pocket [chemical binding]; other site 526225006142 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 526225006143 B12 binding site [chemical binding]; other site 526225006144 cobalt ligand [ion binding]; other site 526225006145 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 526225006146 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 526225006147 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 526225006148 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225006149 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225006150 active site 526225006151 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 526225006152 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 526225006153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225006154 S-adenosylmethionine binding site [chemical binding]; other site 526225006155 proteasome ATPase; Region: pup_AAA; TIGR03689 526225006156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225006157 Walker A motif; other site 526225006158 ATP binding site [chemical binding]; other site 526225006159 Walker B motif; other site 526225006160 arginine finger; other site 526225006161 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 526225006162 Pup-like protein; Region: Pup; cl05289 526225006163 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 526225006164 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 526225006165 active site 526225006166 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 526225006167 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 526225006168 active site 526225006169 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 526225006170 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 526225006171 Predicted transcriptional regulator [Transcription]; Region: COG2378 526225006172 WYL domain; Region: WYL; pfam13280 526225006173 Predicted transcriptional regulator [Transcription]; Region: COG2378 526225006174 WYL domain; Region: WYL; pfam13280 526225006175 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 526225006176 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 526225006177 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 526225006178 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526225006179 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225006180 ATP binding site [chemical binding]; other site 526225006181 putative Mg++ binding site [ion binding]; other site 526225006182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225006183 ATP-binding site [chemical binding]; other site 526225006184 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 526225006185 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 526225006186 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 526225006187 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 526225006188 active site 526225006189 metal binding site 1 [ion binding]; metal-binding site 526225006190 putative 5' ssDNA interaction site; other site 526225006191 metal binding site 3; metal-binding site 526225006192 metal binding site 2 [ion binding]; metal-binding site 526225006193 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 526225006194 putative DNA binding site [nucleotide binding]; other site 526225006195 putative metal binding site [ion binding]; other site 526225006196 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 526225006197 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 526225006198 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 526225006199 active site 526225006200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225006201 putative DNA binding site [nucleotide binding]; other site 526225006202 putative Zn2+ binding site [ion binding]; other site 526225006203 AsnC family; Region: AsnC_trans_reg; pfam01037 526225006204 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 526225006205 protein-splicing catalytic site; other site 526225006206 thioester formation/cholesterol transfer; other site 526225006207 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 526225006208 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 526225006209 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 526225006210 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 526225006211 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 526225006212 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 526225006213 putative acyl-acceptor binding pocket; other site 526225006214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526225006215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225006216 Coenzyme A binding pocket [chemical binding]; other site 526225006217 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 526225006218 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225006219 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225006220 active site 526225006221 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 526225006222 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 526225006223 putative active site [active] 526225006224 catalytic triad [active] 526225006225 putative dimer interface [polypeptide binding]; other site 526225006226 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 526225006227 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 526225006228 Ligand binding site; other site 526225006229 Putative Catalytic site; other site 526225006230 DXD motif; other site 526225006231 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 526225006232 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 526225006233 thymidine kinase; Provisional; Region: PRK04296 526225006234 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526225006235 ATP binding site [chemical binding]; other site 526225006236 Walker A motif; other site 526225006237 Walker B motif; other site 526225006238 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 526225006239 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 526225006240 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 526225006241 putative active site [active] 526225006242 catalytic site [active] 526225006243 putative metal binding site [ion binding]; other site 526225006244 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526225006245 putative active site [active] 526225006246 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225006247 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225006248 active site 526225006249 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 526225006250 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 526225006251 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 526225006252 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 526225006253 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 526225006254 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 526225006255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225006256 motif II; other site 526225006257 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 526225006258 substrate binding site [chemical binding]; other site 526225006259 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 526225006260 pantothenate kinase; Provisional; Region: PRK05439 526225006261 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 526225006262 ATP-binding site [chemical binding]; other site 526225006263 CoA-binding site [chemical binding]; other site 526225006264 Mg2+-binding site [ion binding]; other site 526225006265 glycine dehydrogenase; Provisional; Region: PRK05367 526225006266 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 526225006267 tetramer interface [polypeptide binding]; other site 526225006268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225006269 catalytic residue [active] 526225006270 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 526225006271 tetramer interface [polypeptide binding]; other site 526225006272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225006273 catalytic residue [active] 526225006274 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 526225006275 DNA binding residues [nucleotide binding] 526225006276 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225006277 putative dimer interface [polypeptide binding]; other site 526225006278 Bifunctional nuclease; Region: DNase-RNase; pfam02577 526225006279 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 526225006280 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225006281 DNA binding residues [nucleotide binding] 526225006282 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 526225006283 Double zinc ribbon; Region: DZR; pfam12773 526225006284 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 526225006285 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 526225006286 phosphopeptide binding site; other site 526225006287 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 526225006288 lipoyl attachment site [posttranslational modification]; other site 526225006289 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 526225006290 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 526225006291 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 526225006292 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 526225006293 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 526225006294 elongation factor G; Reviewed; Region: PRK12740 526225006295 G1 box; other site 526225006296 putative GEF interaction site [polypeptide binding]; other site 526225006297 GTP/Mg2+ binding site [chemical binding]; other site 526225006298 Switch I region; other site 526225006299 G2 box; other site 526225006300 G3 box; other site 526225006301 Switch II region; other site 526225006302 G4 box; other site 526225006303 G5 box; other site 526225006304 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 526225006305 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 526225006306 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 526225006307 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 526225006308 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 526225006309 Walker A/P-loop; other site 526225006310 ATP binding site [chemical binding]; other site 526225006311 ABC transporter; Region: ABC_tran; pfam00005 526225006312 Q-loop/lid; other site 526225006313 ABC transporter signature motif; other site 526225006314 Walker B; other site 526225006315 D-loop; other site 526225006316 H-loop/switch region; other site 526225006317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526225006318 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 526225006319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225006320 Walker A/P-loop; other site 526225006321 ATP binding site [chemical binding]; other site 526225006322 Q-loop/lid; other site 526225006323 ABC transporter signature motif; other site 526225006324 Walker B; other site 526225006325 D-loop; other site 526225006326 H-loop/switch region; other site 526225006327 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 526225006328 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 526225006329 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 526225006330 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 526225006331 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 526225006332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225006333 DNA-binding site [nucleotide binding]; DNA binding site 526225006334 UTRA domain; Region: UTRA; pfam07702 526225006335 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 526225006336 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526225006337 substrate binding site [chemical binding]; other site 526225006338 ATP binding site [chemical binding]; other site 526225006339 KduI/IolB family; Region: KduI; pfam04962 526225006340 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 526225006341 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 526225006342 PYR/PP interface [polypeptide binding]; other site 526225006343 dimer interface [polypeptide binding]; other site 526225006344 TPP binding site [chemical binding]; other site 526225006345 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 526225006346 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 526225006347 TPP-binding site; other site 526225006348 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526225006349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225006350 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225006351 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526225006352 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526225006353 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 526225006354 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 526225006355 tetrameric interface [polypeptide binding]; other site 526225006356 NAD binding site [chemical binding]; other site 526225006357 catalytic residues [active] 526225006358 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526225006359 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526225006360 DNA binding site [nucleotide binding] 526225006361 domain linker motif; other site 526225006362 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526225006363 dimerization interface [polypeptide binding]; other site 526225006364 ligand binding site [chemical binding]; other site 526225006365 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526225006366 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 526225006367 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 526225006368 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225006369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225006370 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225006371 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 526225006372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225006373 putative substrate translocation pore; other site 526225006374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225006375 Predicted membrane protein [Function unknown]; Region: COG4129 526225006376 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 526225006377 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 526225006378 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 526225006379 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225006380 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225006381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526225006382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526225006383 DNA binding site [nucleotide binding] 526225006384 domain linker motif; other site 526225006385 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526225006386 ligand binding site [chemical binding]; other site 526225006387 dimerization interface [polypeptide binding]; other site 526225006388 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526225006389 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225006390 Cytochrome P450; Region: p450; cl12078 526225006391 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 526225006392 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 526225006393 FMN-binding pocket [chemical binding]; other site 526225006394 flavin binding motif; other site 526225006395 phosphate binding motif [ion binding]; other site 526225006396 beta-alpha-beta structure motif; other site 526225006397 NAD binding pocket [chemical binding]; other site 526225006398 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225006399 catalytic loop [active] 526225006400 iron binding site [ion binding]; other site 526225006401 Transcriptional regulators [Transcription]; Region: PurR; COG1609 526225006402 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526225006403 DNA binding site [nucleotide binding] 526225006404 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 526225006405 ligand binding site [chemical binding]; other site 526225006406 dimerization interface [polypeptide binding]; other site 526225006407 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225006408 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225006409 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526225006410 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526225006411 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225006412 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225006413 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526225006414 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225006415 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225006416 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526225006417 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 526225006418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 526225006419 DNA binding site [nucleotide binding] 526225006420 domain linker motif; other site 526225006421 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 526225006422 putative ligand binding site [chemical binding]; other site 526225006423 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225006424 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225006425 active site 526225006426 catalytic tetrad [active] 526225006427 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 526225006428 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526225006429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225006430 Walker A/P-loop; other site 526225006431 ATP binding site [chemical binding]; other site 526225006432 Q-loop/lid; other site 526225006433 ABC transporter signature motif; other site 526225006434 Walker B; other site 526225006435 D-loop; other site 526225006436 H-loop/switch region; other site 526225006437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225006438 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526225006439 TM-ABC transporter signature motif; other site 526225006440 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 526225006441 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 526225006442 putative ligand binding site [chemical binding]; other site 526225006443 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225006444 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225006445 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526225006446 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 526225006447 SnoaL-like domain; Region: SnoaL_2; pfam12680 526225006448 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 526225006449 active site 526225006450 catalytic triad [active] 526225006451 oxyanion hole [active] 526225006452 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 526225006453 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 526225006454 active site 526225006455 DNA binding site [nucleotide binding] 526225006456 catalytic site [active] 526225006457 Cupin domain; Region: Cupin_2; pfam07883 526225006458 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 526225006459 putative active site [active] 526225006460 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 526225006461 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225006462 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225006463 active site 526225006464 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 526225006465 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 526225006466 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 526225006467 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 526225006468 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 526225006469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 526225006470 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526225006471 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 526225006472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225006473 motif II; other site 526225006474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225006475 PAS domain; Region: PAS_9; pfam13426 526225006476 putative active site [active] 526225006477 heme pocket [chemical binding]; other site 526225006478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225006479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225006480 metal binding site [ion binding]; metal-binding site 526225006481 active site 526225006482 I-site; other site 526225006483 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 526225006484 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 526225006485 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 526225006486 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 526225006487 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 526225006488 Walker A/P-loop; other site 526225006489 ATP binding site [chemical binding]; other site 526225006490 Q-loop/lid; other site 526225006491 ABC transporter signature motif; other site 526225006492 Walker B; other site 526225006493 D-loop; other site 526225006494 H-loop/switch region; other site 526225006495 TOBE domain; Region: TOBE_2; pfam08402 526225006496 L-idonate 5-dehydrogenase; Region: PLN02702 526225006497 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 526225006498 inhibitor binding site; inhibition site 526225006499 catalytic Zn binding site [ion binding]; other site 526225006500 structural Zn binding site [ion binding]; other site 526225006501 NADP binding site [chemical binding]; other site 526225006502 tetramer interface [polypeptide binding]; other site 526225006503 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526225006504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225006505 dimer interface [polypeptide binding]; other site 526225006506 conserved gate region; other site 526225006507 putative PBP binding loops; other site 526225006508 ABC-ATPase subunit interface; other site 526225006509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225006510 dimer interface [polypeptide binding]; other site 526225006511 conserved gate region; other site 526225006512 putative PBP binding loops; other site 526225006513 ABC-ATPase subunit interface; other site 526225006514 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526225006515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526225006516 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 526225006517 Helix-turn-helix domain; Region: HTH_28; pfam13518 526225006518 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 526225006519 Phosphotransferase enzyme family; Region: APH; pfam01636 526225006520 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 526225006521 active site 526225006522 ATP binding site [chemical binding]; other site 526225006523 substrate binding site [chemical binding]; other site 526225006524 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 526225006525 active site 526225006526 ADP/pyrophosphate binding site [chemical binding]; other site 526225006527 dimerization interface [polypeptide binding]; other site 526225006528 allosteric effector site; other site 526225006529 fructose-1,6-bisphosphate binding site; other site 526225006530 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526225006531 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 526225006532 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 526225006533 TrkA-C domain; Region: TrkA_C; pfam02080 526225006534 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225006535 Ligand Binding Site [chemical binding]; other site 526225006536 MarR family; Region: MarR; pfam01047 526225006537 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 526225006538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225006539 non-specific DNA binding site [nucleotide binding]; other site 526225006540 salt bridge; other site 526225006541 sequence-specific DNA binding site [nucleotide binding]; other site 526225006542 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 526225006543 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 526225006544 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526225006545 inhibitor-cofactor binding pocket; inhibition site 526225006546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225006547 catalytic residue [active] 526225006548 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526225006549 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 526225006550 AsnC family; Region: AsnC_trans_reg; pfam01037 526225006551 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 526225006552 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 526225006553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225006554 dimer interface [polypeptide binding]; other site 526225006555 conserved gate region; other site 526225006556 ABC-ATPase subunit interface; other site 526225006557 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 526225006558 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 526225006559 Walker A/P-loop; other site 526225006560 ATP binding site [chemical binding]; other site 526225006561 Q-loop/lid; other site 526225006562 ABC transporter signature motif; other site 526225006563 Walker B; other site 526225006564 D-loop; other site 526225006565 H-loop/switch region; other site 526225006566 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 526225006567 Sporulation and spore germination; Region: Germane; pfam10646 526225006568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225006569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526225006570 dimerization interface [polypeptide binding]; other site 526225006571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225006572 dimer interface [polypeptide binding]; other site 526225006573 phosphorylation site [posttranslational modification] 526225006574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225006575 ATP binding site [chemical binding]; other site 526225006576 Mg2+ binding site [ion binding]; other site 526225006577 G-X-G motif; other site 526225006578 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225006579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225006580 active site 526225006581 phosphorylation site [posttranslational modification] 526225006582 intermolecular recognition site; other site 526225006583 dimerization interface [polypeptide binding]; other site 526225006584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225006585 DNA binding site [nucleotide binding] 526225006586 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225006587 anti sigma factor interaction site; other site 526225006588 regulatory phosphorylation site [posttranslational modification]; other site 526225006589 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 526225006590 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 526225006591 AAA domain; Region: AAA_30; pfam13604 526225006592 Family description; Region: UvrD_C_2; pfam13538 526225006593 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526225006594 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526225006595 dimer interface [polypeptide binding]; other site 526225006596 ssDNA binding site [nucleotide binding]; other site 526225006597 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526225006598 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 526225006599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225006600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225006601 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225006602 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 526225006603 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225006604 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 526225006605 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 526225006606 FMN-binding pocket [chemical binding]; other site 526225006607 flavin binding motif; other site 526225006608 phosphate binding motif [ion binding]; other site 526225006609 beta-alpha-beta structure motif; other site 526225006610 NAD binding pocket [chemical binding]; other site 526225006611 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225006612 catalytic loop [active] 526225006613 iron binding site [ion binding]; other site 526225006614 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 526225006615 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 526225006616 iron-sulfur cluster [ion binding]; other site 526225006617 [2Fe-2S] cluster binding site [ion binding]; other site 526225006618 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 526225006619 alpha subunit interface [polypeptide binding]; other site 526225006620 active site 526225006621 substrate binding site [chemical binding]; other site 526225006622 Fe binding site [ion binding]; other site 526225006623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225006624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225006625 putative substrate translocation pore; other site 526225006626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225006627 putative substrate translocation pore; other site 526225006628 succinic semialdehyde dehydrogenase; Region: PLN02278 526225006629 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 526225006630 tetramerization interface [polypeptide binding]; other site 526225006631 NAD(P) binding site [chemical binding]; other site 526225006632 catalytic residues [active] 526225006633 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 526225006634 aconitate hydratase; Validated; Region: PRK09277 526225006635 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 526225006636 substrate binding site [chemical binding]; other site 526225006637 ligand binding site [chemical binding]; other site 526225006638 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 526225006639 substrate binding site [chemical binding]; other site 526225006640 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526225006641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225006642 DNA-binding site [nucleotide binding]; DNA binding site 526225006643 FCD domain; Region: FCD; pfam07729 526225006644 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 526225006645 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 526225006646 NodB motif; other site 526225006647 active site 526225006648 catalytic site [active] 526225006649 metal binding site [ion binding]; metal-binding site 526225006650 TIGR03084 family protein; Region: TIGR03084 526225006651 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225006652 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 526225006653 active site 526225006654 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 526225006655 urate oxidase; Region: urate_oxi; TIGR03383 526225006656 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 526225006657 active site 526225006658 allantoicase; Provisional; Region: PRK13257 526225006659 Allantoicase repeat; Region: Allantoicase; pfam03561 526225006660 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 526225006661 allantoinase; Region: allantoinase; TIGR03178 526225006662 active site 526225006663 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 526225006664 allophanate hydrolase; Provisional; Region: PRK08186 526225006665 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526225006666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225006667 DNA-binding site [nucleotide binding]; DNA binding site 526225006668 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 526225006669 fructuronate transporter; Provisional; Region: PRK10034; cl15264 526225006670 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 526225006671 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 526225006672 metal binding site [ion binding]; metal-binding site 526225006673 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 526225006674 substrate binding pocket [chemical binding]; other site 526225006675 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 526225006676 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 526225006677 putative active site [active] 526225006678 putative FMN binding site [chemical binding]; other site 526225006679 putative substrate binding site [chemical binding]; other site 526225006680 putative catalytic residue [active] 526225006681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225006682 Winged helix-turn helix; Region: HTH_29; pfam13551 526225006683 Homeodomain-like domain; Region: HTH_32; pfam13565 526225006684 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526225006685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225006686 DNA-binding site [nucleotide binding]; DNA binding site 526225006687 FCD domain; Region: FCD; pfam07729 526225006688 BCCT family transporter; Region: BCCT; pfam02028 526225006689 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 526225006690 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 526225006691 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 526225006692 [2Fe-2S] cluster binding site [ion binding]; other site 526225006693 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 526225006694 putative alpha subunit interface [polypeptide binding]; other site 526225006695 putative active site [active] 526225006696 putative substrate binding site [chemical binding]; other site 526225006697 Fe binding site [ion binding]; other site 526225006698 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 526225006699 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225006700 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225006701 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 526225006702 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 526225006703 FAD binding pocket [chemical binding]; other site 526225006704 FAD binding motif [chemical binding]; other site 526225006705 phosphate binding motif [ion binding]; other site 526225006706 beta-alpha-beta structure motif; other site 526225006707 NAD binding pocket [chemical binding]; other site 526225006708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225006709 catalytic loop [active] 526225006710 iron binding site [ion binding]; other site 526225006711 Heavy-metal-associated domain; Region: HMA; pfam00403 526225006712 metal-binding site [ion binding] 526225006713 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225006714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225006715 NAD(P) binding site [chemical binding]; other site 526225006716 active site 526225006717 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 526225006718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225006719 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 526225006720 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 526225006721 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225006722 anti sigma factor interaction site; other site 526225006723 regulatory phosphorylation site [posttranslational modification]; other site 526225006724 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225006725 PGAP1-like protein; Region: PGAP1; pfam07819 526225006726 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225006727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225006728 DNA binding residues [nucleotide binding] 526225006729 dimerization interface [polypeptide binding]; other site 526225006730 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225006731 phosphoenolpyruvate synthase; Validated; Region: PRK06464 526225006732 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 526225006733 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 526225006734 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 526225006735 PEP synthetase regulatory protein; Provisional; Region: PRK05339 526225006736 aminodeoxychorismate synthase; Provisional; Region: PRK07508 526225006737 chorismate binding enzyme; Region: Chorismate_bind; cl10555 526225006738 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 526225006739 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 526225006740 substrate-cofactor binding pocket; other site 526225006741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225006742 catalytic residue [active] 526225006743 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 526225006744 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 526225006745 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 526225006746 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 526225006747 putative active site [active] 526225006748 putative substrate binding site [chemical binding]; other site 526225006749 putative cosubstrate binding site; other site 526225006750 catalytic site [active] 526225006751 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 526225006752 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 526225006753 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 526225006754 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526225006755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225006756 DNA-binding site [nucleotide binding]; DNA binding site 526225006757 FCD domain; Region: FCD; pfam07729 526225006758 dihydropteroate synthase; Region: DHPS; TIGR01496 526225006759 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 526225006760 substrate binding pocket [chemical binding]; other site 526225006761 dimer interface [polypeptide binding]; other site 526225006762 inhibitor binding site; inhibition site 526225006763 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 526225006764 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 526225006765 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 526225006766 homodimer interface [polypeptide binding]; other site 526225006767 NADP binding site [chemical binding]; other site 526225006768 substrate binding site [chemical binding]; other site 526225006769 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 526225006770 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526225006771 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526225006772 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 526225006773 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 526225006774 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 526225006775 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 526225006776 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 526225006777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225006778 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 526225006779 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 526225006780 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 526225006781 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 526225006782 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 526225006783 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526225006784 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 526225006785 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 526225006786 dimer interface [polypeptide binding]; other site 526225006787 active site 526225006788 glycine-pyridoxal phosphate binding site [chemical binding]; other site 526225006789 folate binding site [chemical binding]; other site 526225006790 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 526225006791 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 526225006792 NAD binding site [chemical binding]; other site 526225006793 catalytic Zn binding site [ion binding]; other site 526225006794 substrate binding site [chemical binding]; other site 526225006795 structural Zn binding site [ion binding]; other site 526225006796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225006797 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 526225006798 FAD binding site [chemical binding]; other site 526225006799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225006800 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 526225006801 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225006802 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225006803 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 526225006804 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 526225006805 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 526225006806 putative active site [active] 526225006807 putative substrate binding site [chemical binding]; other site 526225006808 putative cosubstrate binding site; other site 526225006809 catalytic site [active] 526225006810 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 526225006811 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 526225006812 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 526225006813 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 526225006814 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 526225006815 [2Fe-2S] cluster binding site [ion binding]; other site 526225006816 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 526225006817 hydrophobic ligand binding site; other site 526225006818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 526225006819 Transposase; Region: DDE_Tnp_ISL3; pfam01610 526225006820 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 526225006821 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 526225006822 FMN-binding pocket [chemical binding]; other site 526225006823 flavin binding motif; other site 526225006824 phosphate binding motif [ion binding]; other site 526225006825 beta-alpha-beta structure motif; other site 526225006826 NAD binding pocket [chemical binding]; other site 526225006827 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225006828 catalytic loop [active] 526225006829 iron binding site [ion binding]; other site 526225006830 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 526225006831 dihydropteroate synthase; Region: DHPS; TIGR01496 526225006832 substrate binding pocket [chemical binding]; other site 526225006833 inhibitor binding site; inhibition site 526225006834 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 526225006835 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 526225006836 NAD binding site [chemical binding]; other site 526225006837 catalytic Zn binding site [ion binding]; other site 526225006838 substrate binding site [chemical binding]; other site 526225006839 structural Zn binding site [ion binding]; other site 526225006840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225006841 Transposase, Mutator family; Region: Transposase_mut; pfam00872 526225006842 MULE transposase domain; Region: MULE; pfam10551 526225006843 BCCT family transporter; Region: BCCT; pfam02028 526225006844 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 526225006845 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225006846 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225006847 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 526225006848 [2Fe-2S] cluster binding site [ion binding]; other site 526225006849 BCCT family transporter; Region: BCCT; pfam02028 526225006850 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 526225006851 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 526225006852 MOSC domain; Region: MOSC; pfam03473 526225006853 DDE superfamily endonuclease; Region: DDE_4; pfam13359 526225006854 Integral membrane protein TerC family; Region: TerC; cl10468 526225006855 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 526225006856 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 526225006857 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225006858 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526225006859 Walker A/P-loop; other site 526225006860 ATP binding site [chemical binding]; other site 526225006861 Q-loop/lid; other site 526225006862 ABC transporter signature motif; other site 526225006863 Walker B; other site 526225006864 D-loop; other site 526225006865 H-loop/switch region; other site 526225006866 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 526225006867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225006868 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 526225006869 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 526225006870 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225006871 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 526225006872 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 526225006873 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 526225006874 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225006875 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 526225006876 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 526225006877 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 526225006878 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 526225006879 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 526225006880 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 526225006881 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 526225006882 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 526225006883 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225006884 Ligand Binding Site [chemical binding]; other site 526225006885 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225006886 anti sigma factor interaction site; other site 526225006887 regulatory phosphorylation site [posttranslational modification]; other site 526225006888 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225006889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225006890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225006891 active site 526225006892 phosphorylation site [posttranslational modification] 526225006893 intermolecular recognition site; other site 526225006894 dimerization interface [polypeptide binding]; other site 526225006895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225006896 DNA binding residues [nucleotide binding] 526225006897 dimerization interface [polypeptide binding]; other site 526225006898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526225006899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225006900 Histidine kinase; Region: HisKA_3; pfam07730 526225006901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225006902 ATP binding site [chemical binding]; other site 526225006903 Mg2+ binding site [ion binding]; other site 526225006904 G-X-G motif; other site 526225006905 potassium/proton antiporter; Reviewed; Region: PRK05326 526225006906 TrkA-C domain; Region: TrkA_C; pfam02080 526225006907 hypothetical protein; Provisional; Region: PRK11573 526225006908 Domain of unknown function DUF21; Region: DUF21; pfam01595 526225006909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 526225006910 Transporter associated domain; Region: CorC_HlyC; pfam03471 526225006911 Domain of unknown function DUF21; Region: DUF21; pfam01595 526225006912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 526225006913 AAA ATPase domain; Region: AAA_16; pfam13191 526225006914 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 526225006915 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225006916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225006917 DNA binding residues [nucleotide binding] 526225006918 dimerization interface [polypeptide binding]; other site 526225006919 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 526225006920 HTH-like domain; Region: HTH_21; pfam13276 526225006921 Integrase core domain; Region: rve; pfam00665 526225006922 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 526225006923 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 526225006924 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 526225006925 transmembrane helices; other site 526225006926 malate dehydrogenase; Provisional; Region: PRK13529 526225006927 Malic enzyme, N-terminal domain; Region: malic; pfam00390 526225006928 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 526225006929 NAD(P) binding pocket [chemical binding]; other site 526225006930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526225006931 E3 interaction surface; other site 526225006932 lipoyl attachment site [posttranslational modification]; other site 526225006933 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526225006934 E3 interaction surface; other site 526225006935 lipoyl attachment site [posttranslational modification]; other site 526225006936 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 526225006937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225006938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225006939 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526225006940 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 526225006941 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526225006942 E3 interaction surface; other site 526225006943 lipoyl attachment site [posttranslational modification]; other site 526225006944 e3 binding domain; Region: E3_binding; pfam02817 526225006945 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 526225006946 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 526225006947 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 526225006948 dimer interface [polypeptide binding]; other site 526225006949 TPP-binding site [chemical binding]; other site 526225006950 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 526225006951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225006952 active site 526225006953 phosphorylation site [posttranslational modification] 526225006954 intermolecular recognition site; other site 526225006955 dimerization interface [polypeptide binding]; other site 526225006956 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 526225006957 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 526225006958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225006959 putative substrate translocation pore; other site 526225006960 Lsr2; Region: Lsr2; pfam11774 526225006961 DDE superfamily endonuclease; Region: DDE_4; pfam13359 526225006962 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 526225006963 putative hydrophobic ligand binding site [chemical binding]; other site 526225006964 Helix-turn-helix domain; Region: HTH_17; pfam12728 526225006965 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 526225006966 Int/Topo IB signature motif; other site 526225006967 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225006968 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225006969 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225006970 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225006971 GTP-binding protein Der; Reviewed; Region: PRK03003 526225006972 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 526225006973 G1 box; other site 526225006974 GTP/Mg2+ binding site [chemical binding]; other site 526225006975 Switch I region; other site 526225006976 G2 box; other site 526225006977 Switch II region; other site 526225006978 G3 box; other site 526225006979 G4 box; other site 526225006980 G5 box; other site 526225006981 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 526225006982 G1 box; other site 526225006983 GTP/Mg2+ binding site [chemical binding]; other site 526225006984 Switch I region; other site 526225006985 G2 box; other site 526225006986 G3 box; other site 526225006987 Switch II region; other site 526225006988 G4 box; other site 526225006989 G5 box; other site 526225006990 cytidylate kinase; Provisional; Region: cmk; PRK00023 526225006991 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 526225006992 active site 526225006993 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 526225006994 CMP-binding site; other site 526225006995 The sites determining sugar specificity; other site 526225006996 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 526225006997 homotrimer interaction site [polypeptide binding]; other site 526225006998 active site 526225006999 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526225007000 D-xylulose kinase; Region: XylB; TIGR01312 526225007001 nucleotide binding site [chemical binding]; other site 526225007002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526225007003 xylose isomerase; Provisional; Region: PRK12677 526225007004 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 526225007005 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526225007006 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 526225007007 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 526225007008 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 526225007009 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 526225007010 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526225007011 RNA binding surface [nucleotide binding]; other site 526225007012 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 526225007013 active site 526225007014 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 526225007015 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 526225007016 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 526225007017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526225007018 P-loop; other site 526225007019 Magnesium ion binding site [ion binding]; other site 526225007020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526225007021 Magnesium ion binding site [ion binding]; other site 526225007022 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 526225007023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225007024 active site 526225007025 DNA binding site [nucleotide binding] 526225007026 Int/Topo IB signature motif; other site 526225007027 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 526225007028 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 526225007029 hexamer interface [polypeptide binding]; other site 526225007030 ligand binding site [chemical binding]; other site 526225007031 putative active site [active] 526225007032 NAD(P) binding site [chemical binding]; other site 526225007033 Domain of unknown function (DUF336); Region: DUF336; pfam03928 526225007034 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 526225007035 Peptidase family M28; Region: Peptidase_M28; pfam04389 526225007036 metal binding site [ion binding]; metal-binding site 526225007037 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 526225007038 dimer interface [polypeptide binding]; other site 526225007039 ADP-ribose binding site [chemical binding]; other site 526225007040 active site 526225007041 nudix motif; other site 526225007042 metal binding site [ion binding]; metal-binding site 526225007043 CTP synthetase; Validated; Region: pyrG; PRK05380 526225007044 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 526225007045 Catalytic site [active] 526225007046 active site 526225007047 UTP binding site [chemical binding]; other site 526225007048 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 526225007049 active site 526225007050 putative oxyanion hole; other site 526225007051 catalytic triad [active] 526225007052 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 526225007053 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225007054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225007055 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 526225007056 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 526225007057 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 526225007058 Thiamine pyrophosphokinase; Region: TPK; cl08415 526225007059 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 526225007060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225007061 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 526225007062 Methyltransferase domain; Region: Methyltransf_26; pfam13659 526225007063 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 526225007064 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 526225007065 Walker A/P-loop; other site 526225007066 ATP binding site [chemical binding]; other site 526225007067 Q-loop/lid; other site 526225007068 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 526225007069 ABC transporter signature motif; other site 526225007070 Walker B; other site 526225007071 D-loop; other site 526225007072 H-loop/switch region; other site 526225007073 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 526225007074 ATP-NAD kinase; Region: NAD_kinase; pfam01513 526225007075 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 526225007076 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526225007077 RNA binding surface [nucleotide binding]; other site 526225007078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225007079 S-adenosylmethionine binding site [chemical binding]; other site 526225007080 SCP-2 sterol transfer family; Region: SCP2; cl01225 526225007081 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 526225007082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225007083 active site 526225007084 motif I; other site 526225007085 motif II; other site 526225007086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225007087 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 526225007088 Uncharacterized conserved protein [Function unknown]; Region: COG4198 526225007089 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 526225007090 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526225007091 dimer interface [polypeptide binding]; other site 526225007092 ssDNA binding site [nucleotide binding]; other site 526225007093 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526225007094 transcription termination factor Rho; Provisional; Region: PRK12678 526225007095 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 526225007096 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 526225007097 active site 526225007098 HIGH motif; other site 526225007099 dimer interface [polypeptide binding]; other site 526225007100 KMSKS motif; other site 526225007101 S4 RNA-binding domain; Region: S4; smart00363 526225007102 RNA binding surface [nucleotide binding]; other site 526225007103 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 526225007104 active site 526225007105 DNA binding site [nucleotide binding] 526225007106 argininosuccinate lyase; Provisional; Region: PRK00855 526225007107 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 526225007108 active sites [active] 526225007109 tetramer interface [polypeptide binding]; other site 526225007110 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 526225007111 arginine repressor; Provisional; Region: PRK04280 526225007112 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 526225007113 ornithine carbamoyltransferase; Provisional; Region: PRK00779 526225007114 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 526225007115 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 526225007116 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 526225007117 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526225007118 inhibitor-cofactor binding pocket; inhibition site 526225007119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225007120 catalytic residue [active] 526225007121 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 526225007122 feedback inhibition sensing region; other site 526225007123 homohexameric interface [polypeptide binding]; other site 526225007124 nucleotide binding site [chemical binding]; other site 526225007125 N-acetyl-L-glutamate binding site [chemical binding]; other site 526225007126 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 526225007127 heterotetramer interface [polypeptide binding]; other site 526225007128 active site pocket [active] 526225007129 cleavage site 526225007130 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 526225007131 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 526225007132 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 526225007133 active site 526225007134 nucleophile elbow; other site 526225007135 Fusaric acid resistance protein family; Region: FUSC; pfam04632 526225007136 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526225007137 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 526225007138 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 526225007139 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 526225007140 putative tRNA-binding site [nucleotide binding]; other site 526225007141 B3/4 domain; Region: B3_4; pfam03483 526225007142 tRNA synthetase B5 domain; Region: B5; smart00874 526225007143 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 526225007144 dimer interface [polypeptide binding]; other site 526225007145 motif 1; other site 526225007146 motif 3; other site 526225007147 motif 2; other site 526225007148 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 526225007149 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 526225007150 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 526225007151 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 526225007152 dimer interface [polypeptide binding]; other site 526225007153 motif 1; other site 526225007154 active site 526225007155 motif 2; other site 526225007156 motif 3; other site 526225007157 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 526225007158 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 526225007159 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 526225007160 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 526225007161 23S rRNA binding site [nucleotide binding]; other site 526225007162 L21 binding site [polypeptide binding]; other site 526225007163 L13 binding site [polypeptide binding]; other site 526225007164 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 526225007165 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 526225007166 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 526225007167 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 526225007168 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 526225007169 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225007170 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 526225007171 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225007172 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 526225007173 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 526225007174 active site 526225007175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225007176 DNA binding site [nucleotide binding] 526225007177 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 526225007178 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 526225007179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225007180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225007181 DNA binding residues [nucleotide binding] 526225007182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225007183 S-adenosylmethionine binding site [chemical binding]; other site 526225007184 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225007185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225007186 sequence-specific DNA binding site [nucleotide binding]; other site 526225007187 salt bridge; other site 526225007188 Cupin domain; Region: Cupin_2; pfam07883 526225007189 O-methyltransferase; Region: Methyltransf_2; pfam00891 526225007190 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 526225007191 iron-sulfur cluster [ion binding]; other site 526225007192 [2Fe-2S] cluster binding site [ion binding]; other site 526225007193 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 526225007194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225007195 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 526225007196 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 526225007197 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 526225007198 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 526225007199 [4Fe-4S] binding site [ion binding]; other site 526225007200 molybdopterin cofactor binding site; other site 526225007201 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 526225007202 molybdopterin cofactor binding site; other site 526225007203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225007204 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526225007205 Coenzyme A binding pocket [chemical binding]; other site 526225007206 YCII-related domain; Region: YCII; cl00999 526225007207 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 526225007208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225007209 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225007210 DNA binding residues [nucleotide binding] 526225007211 hypothetical protein; Provisional; Region: PRK09256 526225007212 Haemolytic domain; Region: Haemolytic; pfam01809 526225007213 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 526225007214 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 526225007215 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526225007216 putative trimer interface [polypeptide binding]; other site 526225007217 putative CoA binding site [chemical binding]; other site 526225007218 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526225007219 putative trimer interface [polypeptide binding]; other site 526225007220 putative CoA binding site [chemical binding]; other site 526225007221 short chain dehydrogenase; Provisional; Region: PRK06701 526225007222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225007223 NAD(P) binding site [chemical binding]; other site 526225007224 active site 526225007225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 526225007226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225007227 ATP binding site [chemical binding]; other site 526225007228 putative Mg++ binding site [ion binding]; other site 526225007229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225007230 nucleotide binding region [chemical binding]; other site 526225007231 ATP-binding site [chemical binding]; other site 526225007232 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 526225007233 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 526225007234 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 526225007235 dimer interface [polypeptide binding]; other site 526225007236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225007237 catalytic residue [active] 526225007238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 526225007239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 526225007240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 526225007241 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 526225007242 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526225007243 putative trimer interface [polypeptide binding]; other site 526225007244 putative CoA binding site [chemical binding]; other site 526225007245 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 526225007246 putative CoA binding site [chemical binding]; other site 526225007247 putative trimer interface [polypeptide binding]; other site 526225007248 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 526225007249 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 526225007250 acyl-activating enzyme (AAE) consensus motif; other site 526225007251 AMP binding site [chemical binding]; other site 526225007252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 526225007253 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 526225007254 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 526225007255 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 526225007256 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 526225007257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225007258 catalytic residue [active] 526225007259 Protein of unknown function (DUF418); Region: DUF418; cl12135 526225007260 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 526225007261 trehalose synthase; Region: treS_nterm; TIGR02456 526225007262 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 526225007263 active site 526225007264 catalytic site [active] 526225007265 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 526225007266 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 526225007267 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225007268 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225007269 metal binding site [ion binding]; metal-binding site 526225007270 active site 526225007271 I-site; other site 526225007272 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225007273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 526225007274 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 526225007275 Coenzyme A transferase; Region: CoA_trans; cl17247 526225007276 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 526225007277 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 526225007278 PYR/PP interface [polypeptide binding]; other site 526225007279 dimer interface [polypeptide binding]; other site 526225007280 TPP binding site [chemical binding]; other site 526225007281 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 526225007282 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 526225007283 TPP-binding site [chemical binding]; other site 526225007284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 526225007285 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 526225007286 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 526225007287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 526225007288 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 526225007289 dimerization interface [polypeptide binding]; other site 526225007290 substrate binding pocket [chemical binding]; other site 526225007291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 526225007292 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 526225007293 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 526225007294 hypothetical protein; Provisional; Region: PRK07877 526225007295 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225007296 Ligand Binding Site [chemical binding]; other site 526225007297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225007298 NADH(P)-binding; Region: NAD_binding_10; pfam13460 526225007299 NAD(P) binding site [chemical binding]; other site 526225007300 active site 526225007301 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225007302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225007303 non-specific DNA binding site [nucleotide binding]; other site 526225007304 salt bridge; other site 526225007305 sequence-specific DNA binding site [nucleotide binding]; other site 526225007306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 526225007307 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 526225007308 putative active site [active] 526225007309 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 526225007310 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 526225007311 NADP binding site [chemical binding]; other site 526225007312 homotetramer interface [polypeptide binding]; other site 526225007313 homodimer interface [polypeptide binding]; other site 526225007314 active site 526225007315 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 526225007316 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225007317 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 526225007318 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 526225007319 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 526225007320 HisG, C-terminal domain; Region: HisG_C; pfam08029 526225007321 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 526225007322 homodimer interface [polypeptide binding]; other site 526225007323 putative metal binding site [ion binding]; other site 526225007324 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 526225007325 homopentamer interface [polypeptide binding]; other site 526225007326 active site 526225007327 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 526225007328 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 526225007329 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 526225007330 dimerization interface [polypeptide binding]; other site 526225007331 active site 526225007332 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 526225007333 Lumazine binding domain; Region: Lum_binding; pfam00677 526225007334 Lumazine binding domain; Region: Lum_binding; pfam00677 526225007335 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 526225007336 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 526225007337 catalytic motif [active] 526225007338 Zn binding site [ion binding]; other site 526225007339 RibD C-terminal domain; Region: RibD_C; cl17279 526225007340 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 526225007341 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 526225007342 substrate binding site [chemical binding]; other site 526225007343 hexamer interface [polypeptide binding]; other site 526225007344 metal binding site [ion binding]; metal-binding site 526225007345 Histidine kinase; Region: HisKA_3; pfam07730 526225007346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225007347 ATP binding site [chemical binding]; other site 526225007348 Mg2+ binding site [ion binding]; other site 526225007349 G-X-G motif; other site 526225007350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225007351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225007352 active site 526225007353 phosphorylation site [posttranslational modification] 526225007354 intermolecular recognition site; other site 526225007355 dimerization interface [polypeptide binding]; other site 526225007356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225007357 DNA binding residues [nucleotide binding] 526225007358 dimerization interface [polypeptide binding]; other site 526225007359 16S rRNA methyltransferase B; Provisional; Region: PRK14902 526225007360 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 526225007361 putative RNA binding site [nucleotide binding]; other site 526225007362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225007363 S-adenosylmethionine binding site [chemical binding]; other site 526225007364 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 526225007365 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 526225007366 putative active site [active] 526225007367 substrate binding site [chemical binding]; other site 526225007368 putative cosubstrate binding site; other site 526225007369 catalytic site [active] 526225007370 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 526225007371 substrate binding site [chemical binding]; other site 526225007372 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 526225007373 active site 526225007374 catalytic residues [active] 526225007375 metal binding site [ion binding]; metal-binding site 526225007376 primosome assembly protein PriA; Provisional; Region: PRK14873 526225007377 S-adenosylmethionine synthetase; Validated; Region: PRK05250 526225007378 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 526225007379 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 526225007380 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 526225007381 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 526225007382 Flavoprotein; Region: Flavoprotein; pfam02441 526225007383 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 526225007384 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 526225007385 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 526225007386 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 526225007387 catalytic site [active] 526225007388 G-X2-G-X-G-K; other site 526225007389 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 526225007390 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 526225007391 active site 526225007392 dimer interface [polypeptide binding]; other site 526225007393 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225007394 phosphate binding site [ion binding]; other site 526225007395 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 526225007396 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526225007397 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225007398 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 526225007399 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526225007400 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225007401 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 526225007402 IMP binding site; other site 526225007403 dimer interface [polypeptide binding]; other site 526225007404 interdomain contacts; other site 526225007405 partial ornithine binding site; other site 526225007406 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 526225007407 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 526225007408 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 526225007409 catalytic site [active] 526225007410 subunit interface [polypeptide binding]; other site 526225007411 dihydroorotase; Validated; Region: pyrC; PRK09357 526225007412 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225007413 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 526225007414 active site 526225007415 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 526225007416 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 526225007417 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 526225007418 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 526225007419 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 526225007420 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225007421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225007422 non-specific DNA binding site [nucleotide binding]; other site 526225007423 salt bridge; other site 526225007424 sequence-specific DNA binding site [nucleotide binding]; other site 526225007425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225007426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225007427 DNA binding residues [nucleotide binding] 526225007428 dimerization interface [polypeptide binding]; other site 526225007429 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 526225007430 transcription antitermination factor NusB; Region: nusB; TIGR01951 526225007431 putative RNA binding site [nucleotide binding]; other site 526225007432 elongation factor P; Validated; Region: PRK00529 526225007433 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 526225007434 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 526225007435 RNA binding site [nucleotide binding]; other site 526225007436 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 526225007437 RNA binding site [nucleotide binding]; other site 526225007438 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 526225007439 aminopeptidase; Provisional; Region: PRK09795 526225007440 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 526225007441 active site 526225007442 Dehydroquinase class II; Region: DHquinase_II; pfam01220 526225007443 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 526225007444 trimer interface [polypeptide binding]; other site 526225007445 active site 526225007446 dimer interface [polypeptide binding]; other site 526225007447 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 526225007448 active site 526225007449 dimer interface [polypeptide binding]; other site 526225007450 metal binding site [ion binding]; metal-binding site 526225007451 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 526225007452 Shikimate kinase; Region: SKI; pfam01202 526225007453 ADP binding site [chemical binding]; other site 526225007454 magnesium binding site [ion binding]; other site 526225007455 putative shikimate binding site; other site 526225007456 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 526225007457 chorismate synthase; Validated; Region: PRK05382 526225007458 Tetramer interface [polypeptide binding]; other site 526225007459 active site 526225007460 FMN-binding site [chemical binding]; other site 526225007461 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 526225007462 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 526225007463 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 526225007464 shikimate binding site; other site 526225007465 NAD(P) binding site [chemical binding]; other site 526225007466 YceG-like family; Region: YceG; pfam02618 526225007467 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 526225007468 dimerization interface [polypeptide binding]; other site 526225007469 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 526225007470 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 526225007471 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 526225007472 motif 1; other site 526225007473 active site 526225007474 motif 2; other site 526225007475 motif 3; other site 526225007476 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 526225007477 recombination factor protein RarA; Reviewed; Region: PRK13342 526225007478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225007479 Walker A motif; other site 526225007480 ATP binding site [chemical binding]; other site 526225007481 Walker B motif; other site 526225007482 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 526225007483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225007484 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225007485 active site 526225007486 catalytic tetrad [active] 526225007487 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 526225007488 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 526225007489 dimer interface [polypeptide binding]; other site 526225007490 anticodon binding site; other site 526225007491 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 526225007492 homodimer interface [polypeptide binding]; other site 526225007493 motif 1; other site 526225007494 active site 526225007495 motif 2; other site 526225007496 GAD domain; Region: GAD; pfam02938 526225007497 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526225007498 active site 526225007499 motif 3; other site 526225007500 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225007501 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225007502 active site 526225007503 catalytic tetrad [active] 526225007504 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 526225007505 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 526225007506 dimer interface [polypeptide binding]; other site 526225007507 motif 1; other site 526225007508 active site 526225007509 motif 2; other site 526225007510 motif 3; other site 526225007511 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 526225007512 anticodon binding site; other site 526225007513 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 526225007514 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 526225007515 active site 526225007516 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 526225007517 active site 526225007518 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 526225007519 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526225007520 Zn2+ binding site [ion binding]; other site 526225007521 Mg2+ binding site [ion binding]; other site 526225007522 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 526225007523 synthetase active site [active] 526225007524 NTP binding site [chemical binding]; other site 526225007525 metal binding site [ion binding]; metal-binding site 526225007526 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 526225007527 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 526225007528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526225007529 active site 526225007530 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 526225007531 Protein export membrane protein; Region: SecD_SecF; cl14618 526225007532 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 526225007533 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 526225007534 Preprotein translocase subunit; Region: YajC; pfam02699 526225007535 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 526225007536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225007537 Walker A motif; other site 526225007538 ATP binding site [chemical binding]; other site 526225007539 Walker B motif; other site 526225007540 arginine finger; other site 526225007541 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 526225007542 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 526225007543 RuvA N terminal domain; Region: RuvA_N; pfam01330 526225007544 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 526225007545 active site 526225007546 putative DNA-binding cleft [nucleotide binding]; other site 526225007547 dimer interface [polypeptide binding]; other site 526225007548 hypothetical protein; Validated; Region: PRK00110 526225007549 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 526225007550 predicted active site [active] 526225007551 catalytic triad [active] 526225007552 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 526225007553 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 526225007554 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 526225007555 active site 526225007556 multimer interface [polypeptide binding]; other site 526225007557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225007558 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225007559 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 526225007560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 526225007561 putative acyl-acceptor binding pocket; other site 526225007562 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 526225007563 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 526225007564 nucleotide binding site/active site [active] 526225007565 HIT family signature motif; other site 526225007566 catalytic residue [active] 526225007567 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 526225007568 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 526225007569 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 526225007570 active site 526225007571 dimer interface [polypeptide binding]; other site 526225007572 motif 1; other site 526225007573 motif 2; other site 526225007574 motif 3; other site 526225007575 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 526225007576 anticodon binding site; other site 526225007577 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 526225007578 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 526225007579 MOSC domain; Region: MOSC; pfam03473 526225007580 HNH endonuclease; Region: HNH; pfam01844 526225007581 RibD C-terminal domain; Region: RibD_C; cl17279 526225007582 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 526225007583 Putative zinc-finger; Region: zf-HC2; pfam13490 526225007584 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 526225007585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225007586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225007587 DNA binding residues [nucleotide binding] 526225007588 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 526225007589 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 526225007590 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 526225007591 CoA-binding site [chemical binding]; other site 526225007592 ATP-binding [chemical binding]; other site 526225007593 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 526225007594 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 526225007595 RNA binding site [nucleotide binding]; other site 526225007596 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 526225007597 RNA binding site [nucleotide binding]; other site 526225007598 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 526225007599 RNA binding site [nucleotide binding]; other site 526225007600 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 526225007601 RNA binding site [nucleotide binding]; other site 526225007602 domain interface; other site 526225007603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225007604 S-adenosylmethionine binding site [chemical binding]; other site 526225007605 DNA polymerase I; Provisional; Region: PRK05755 526225007606 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 526225007607 active site 526225007608 putative 5' ssDNA interaction site; other site 526225007609 metal binding site 3; metal-binding site 526225007610 metal binding site 1 [ion binding]; metal-binding site 526225007611 metal binding site 2 [ion binding]; metal-binding site 526225007612 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 526225007613 putative DNA binding site [nucleotide binding]; other site 526225007614 putative metal binding site [ion binding]; other site 526225007615 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 526225007616 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 526225007617 active site 526225007618 DNA binding site [nucleotide binding] 526225007619 catalytic site [active] 526225007620 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526225007621 CoenzymeA binding site [chemical binding]; other site 526225007622 subunit interaction site [polypeptide binding]; other site 526225007623 PHB binding site; other site 526225007624 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 526225007625 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225007626 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526225007627 TM-ABC transporter signature motif; other site 526225007628 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225007629 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526225007630 TM-ABC transporter signature motif; other site 526225007631 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526225007632 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526225007633 Walker A/P-loop; other site 526225007634 ATP binding site [chemical binding]; other site 526225007635 Q-loop/lid; other site 526225007636 ABC transporter signature motif; other site 526225007637 Walker B; other site 526225007638 D-loop; other site 526225007639 H-loop/switch region; other site 526225007640 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526225007641 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526225007642 Walker A/P-loop; other site 526225007643 ATP binding site [chemical binding]; other site 526225007644 Q-loop/lid; other site 526225007645 ABC transporter signature motif; other site 526225007646 Walker B; other site 526225007647 D-loop; other site 526225007648 H-loop/switch region; other site 526225007649 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 526225007650 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526225007651 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 526225007652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225007653 active site 526225007654 phosphorylation site [posttranslational modification] 526225007655 intermolecular recognition site; other site 526225007656 dimerization interface [polypeptide binding]; other site 526225007657 ANTAR domain; Region: ANTAR; pfam03861 526225007658 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526225007659 tyrosine decarboxylase; Region: PLN02880 526225007660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225007661 catalytic residue [active] 526225007662 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 526225007663 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 526225007664 active site 526225007665 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 526225007666 catalytic triad [active] 526225007667 dimer interface [polypeptide binding]; other site 526225007668 pyruvate kinase; Provisional; Region: PRK06247 526225007669 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 526225007670 domain interfaces; other site 526225007671 active site 526225007672 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 526225007673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225007674 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 526225007675 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 526225007676 active site 526225007677 dimer interface [polypeptide binding]; other site 526225007678 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 526225007679 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 526225007680 active site 526225007681 FMN binding site [chemical binding]; other site 526225007682 substrate binding site [chemical binding]; other site 526225007683 3Fe-4S cluster binding site [ion binding]; other site 526225007684 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 526225007685 domain interface; other site 526225007686 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 526225007687 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 526225007688 substrate binding site [chemical binding]; other site 526225007689 active site 526225007690 catalytic residues [active] 526225007691 heterodimer interface [polypeptide binding]; other site 526225007692 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 526225007693 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 526225007694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225007695 catalytic residue [active] 526225007696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526225007697 active site 526225007698 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 526225007699 active site 526225007700 ribulose/triose binding site [chemical binding]; other site 526225007701 phosphate binding site [ion binding]; other site 526225007702 substrate (anthranilate) binding pocket [chemical binding]; other site 526225007703 product (indole) binding pocket [chemical binding]; other site 526225007704 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 526225007705 anthranilate synthase component I; Provisional; Region: PRK13571 526225007706 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 526225007707 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 526225007708 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 526225007709 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 526225007710 FAD binding domain; Region: FAD_binding_2; pfam00890 526225007711 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 526225007712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526225007713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225007714 Walker A/P-loop; other site 526225007715 ATP binding site [chemical binding]; other site 526225007716 Q-loop/lid; other site 526225007717 ABC transporter signature motif; other site 526225007718 Walker B; other site 526225007719 D-loop; other site 526225007720 H-loop/switch region; other site 526225007721 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 526225007722 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 526225007723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225007724 Walker A/P-loop; other site 526225007725 ATP binding site [chemical binding]; other site 526225007726 Q-loop/lid; other site 526225007727 ABC transporter signature motif; other site 526225007728 Walker B; other site 526225007729 D-loop; other site 526225007730 H-loop/switch region; other site 526225007731 TIGR03085 family protein; Region: TIGR03085 526225007732 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 526225007733 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 526225007734 substrate binding site [chemical binding]; other site 526225007735 glutamase interaction surface [polypeptide binding]; other site 526225007736 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 526225007737 homotrimer interaction site [polypeptide binding]; other site 526225007738 putative active site [active] 526225007739 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 526225007740 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 526225007741 catalytic residues [active] 526225007742 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 526225007743 FMN binding site [chemical binding]; other site 526225007744 dimer interface [polypeptide binding]; other site 526225007745 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 526225007746 classical (c) SDRs; Region: SDR_c; cd05233 526225007747 NAD(P) binding site [chemical binding]; other site 526225007748 active site 526225007749 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526225007750 metal coordination site [ion binding]; other site 526225007751 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 526225007752 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 526225007753 putative active site [active] 526225007754 oxyanion strand; other site 526225007755 catalytic triad [active] 526225007756 Domain of unknown function (DUF222); Region: DUF222; pfam02720 526225007757 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 526225007758 putative active site pocket [active] 526225007759 4-fold oligomerization interface [polypeptide binding]; other site 526225007760 metal binding residues [ion binding]; metal-binding site 526225007761 3-fold/trimer interface [polypeptide binding]; other site 526225007762 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 526225007763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526225007764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225007765 homodimer interface [polypeptide binding]; other site 526225007766 catalytic residue [active] 526225007767 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 526225007768 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 526225007769 NAD binding site [chemical binding]; other site 526225007770 dimerization interface [polypeptide binding]; other site 526225007771 product binding site; other site 526225007772 substrate binding site [chemical binding]; other site 526225007773 zinc binding site [ion binding]; other site 526225007774 catalytic residues [active] 526225007775 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 526225007776 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 526225007777 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 526225007778 active site 526225007779 PHP Thumb interface [polypeptide binding]; other site 526225007780 metal binding site [ion binding]; metal-binding site 526225007781 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 526225007782 generic binding surface II; other site 526225007783 generic binding surface I; other site 526225007784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526225007785 CAAX protease self-immunity; Region: Abi; pfam02517 526225007786 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 526225007787 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 526225007788 active site 526225007789 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 526225007790 malate:quinone oxidoreductase; Validated; Region: PRK05257 526225007791 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 526225007792 potassium/proton antiporter; Reviewed; Region: PRK05326 526225007793 TrkA-C domain; Region: TrkA_C; pfam02080 526225007794 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 526225007795 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225007796 active site 526225007797 HIGH motif; other site 526225007798 nucleotide binding site [chemical binding]; other site 526225007799 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 526225007800 active site 526225007801 KMSKS motif; other site 526225007802 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 526225007803 tRNA binding surface [nucleotide binding]; other site 526225007804 anticodon binding site; other site 526225007805 DivIVA protein; Region: DivIVA; pfam05103 526225007806 DivIVA domain; Region: DivI1A_domain; TIGR03544 526225007807 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 526225007808 YGGT family; Region: YGGT; pfam02325 526225007809 Protein of unknown function (DUF552); Region: DUF552; cl00775 526225007810 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 526225007811 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526225007812 catalytic residue [active] 526225007813 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 526225007814 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 526225007815 cell division protein FtsZ; Validated; Region: PRK09330 526225007816 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 526225007817 nucleotide binding site [chemical binding]; other site 526225007818 SulA interaction site; other site 526225007819 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 526225007820 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 526225007821 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 526225007822 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 526225007823 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 526225007824 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526225007825 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526225007826 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526225007827 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 526225007828 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 526225007829 active site 526225007830 homodimer interface [polypeptide binding]; other site 526225007831 cell division protein FtsW; Region: ftsW; TIGR02614 526225007832 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 526225007833 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 526225007834 Mg++ binding site [ion binding]; other site 526225007835 putative catalytic motif [active] 526225007836 putative substrate binding site [chemical binding]; other site 526225007837 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 526225007838 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526225007839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526225007840 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 526225007841 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 526225007842 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526225007843 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526225007844 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 526225007845 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 526225007846 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 526225007847 MraW methylase family; Region: Methyltransf_5; cl17771 526225007848 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 526225007849 cell division protein MraZ; Reviewed; Region: PRK00326 526225007850 MraZ protein; Region: MraZ; pfam02381 526225007851 MraZ protein; Region: MraZ; pfam02381 526225007852 MoxR-like ATPases [General function prediction only]; Region: COG0714 526225007853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225007854 ATP binding site [chemical binding]; other site 526225007855 Walker A motif; other site 526225007856 Walker B motif; other site 526225007857 arginine finger; other site 526225007858 Protein of unknown function DUF58; Region: DUF58; pfam01882 526225007859 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 526225007860 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 526225007861 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 526225007862 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 526225007863 active site 526225007864 DNA polymerase IV; Validated; Region: PRK02406 526225007865 DNA binding site [nucleotide binding] 526225007866 Cupin-like domain; Region: Cupin_8; pfam13621 526225007867 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 526225007868 putative dimer interface [polypeptide binding]; other site 526225007869 putative [2Fe-2S] cluster binding site [ion binding]; other site 526225007870 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225007871 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225007872 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 526225007873 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 526225007874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225007875 S-adenosylmethionine binding site [chemical binding]; other site 526225007876 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 526225007877 dimer interface [polypeptide binding]; other site 526225007878 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 526225007879 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 526225007880 active site 526225007881 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 526225007882 generic binding surface II; other site 526225007883 generic binding surface I; other site 526225007884 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 526225007885 putative deacylase active site [active] 526225007886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225007887 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526225007888 Coenzyme A binding pocket [chemical binding]; other site 526225007889 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 526225007890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225007891 Protein of unknown function (DUF422); Region: DUF422; cl00991 526225007892 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225007893 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 526225007894 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 526225007895 substrate binding site [chemical binding]; other site 526225007896 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526225007897 ATP binding site [chemical binding]; other site 526225007898 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 526225007899 Lipase (class 2); Region: Lipase_2; pfam01674 526225007900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225007901 dimerization interface [polypeptide binding]; other site 526225007902 putative DNA binding site [nucleotide binding]; other site 526225007903 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225007904 putative Zn2+ binding site [ion binding]; other site 526225007905 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 526225007906 putative hydrophobic ligand binding site [chemical binding]; other site 526225007907 TIGR03086 family protein; Region: TIGR03086 526225007908 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225007909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225007910 Walker A/P-loop; other site 526225007911 ATP binding site [chemical binding]; other site 526225007912 Q-loop/lid; other site 526225007913 ABC transporter signature motif; other site 526225007914 Walker B; other site 526225007915 D-loop; other site 526225007916 H-loop/switch region; other site 526225007917 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 526225007918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 526225007919 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 526225007920 FAD binding site [chemical binding]; other site 526225007921 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 526225007922 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 526225007923 substrate binding pocket [chemical binding]; other site 526225007924 chain length determination region; other site 526225007925 substrate-Mg2+ binding site; other site 526225007926 catalytic residues [active] 526225007927 aspartate-rich region 1; other site 526225007928 active site lid residues [active] 526225007929 aspartate-rich region 2; other site 526225007930 phytoene desaturase; Region: crtI_fam; TIGR02734 526225007931 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 526225007932 active site lid residues [active] 526225007933 substrate binding pocket [chemical binding]; other site 526225007934 catalytic residues [active] 526225007935 substrate-Mg2+ binding site; other site 526225007936 aspartate-rich region 1; other site 526225007937 aspartate-rich region 2; other site 526225007938 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 526225007939 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 526225007940 Helix-turn-helix domain; Region: HTH_17; pfam12728 526225007941 serine hydroxymethyltransferase; Provisional; Region: PRK13580 526225007942 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 526225007943 dimer interface [polypeptide binding]; other site 526225007944 active site 526225007945 glycine-pyridoxal phosphate binding site [chemical binding]; other site 526225007946 folate binding site [chemical binding]; other site 526225007947 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225007948 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225007949 active site 526225007950 ATP binding site [chemical binding]; other site 526225007951 substrate binding site [chemical binding]; other site 526225007952 activation loop (A-loop); other site 526225007953 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225007954 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225007955 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225007956 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 526225007957 AP endonuclease family 2; Region: AP2Ec; smart00518 526225007958 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 526225007959 AP (apurinic/apyrimidinic) site pocket; other site 526225007960 DNA interaction; other site 526225007961 Metal-binding active site; metal-binding site 526225007962 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 526225007963 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 526225007964 tetramer interface [polypeptide binding]; other site 526225007965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225007966 catalytic residue [active] 526225007967 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 526225007968 phosphofructokinase; Region: PFK_mixed; TIGR02483 526225007969 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 526225007970 active site 526225007971 ADP/pyrophosphate binding site [chemical binding]; other site 526225007972 dimerization interface [polypeptide binding]; other site 526225007973 allosteric effector site; other site 526225007974 fructose-1,6-bisphosphate binding site; other site 526225007975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225007976 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 526225007977 NAD(P) binding site [chemical binding]; other site 526225007978 active site 526225007979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526225007980 dimerization interface [polypeptide binding]; other site 526225007981 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 526225007982 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526225007983 dimer interface [polypeptide binding]; other site 526225007984 putative CheW interface [polypeptide binding]; other site 526225007985 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 526225007986 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 526225007987 putative acyl-acceptor binding pocket; other site 526225007988 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 526225007989 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526225007990 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 526225007991 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 526225007992 putative hydrophobic ligand binding site [chemical binding]; other site 526225007993 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 526225007994 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 526225007995 acyl-activating enzyme (AAE) consensus motif; other site 526225007996 putative AMP binding site [chemical binding]; other site 526225007997 putative active site [active] 526225007998 putative CoA binding site [chemical binding]; other site 526225007999 Peptidase family M48; Region: Peptidase_M48; cl12018 526225008000 NlpC/P60 family; Region: NLPC_P60; cl17555 526225008001 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 526225008002 hypothetical protein; Validated; Region: PRK07883 526225008003 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 526225008004 active site 526225008005 catalytic site [active] 526225008006 substrate binding site [chemical binding]; other site 526225008007 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 526225008008 GIY-YIG motif/motif A; other site 526225008009 active site 526225008010 catalytic site [active] 526225008011 putative DNA binding site [nucleotide binding]; other site 526225008012 metal binding site [ion binding]; metal-binding site 526225008013 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526225008014 AsnC family; Region: AsnC_trans_reg; pfam01037 526225008015 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 526225008016 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 526225008017 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 526225008018 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 526225008019 Subunit I/III interface [polypeptide binding]; other site 526225008020 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 526225008021 Cytochrome c; Region: Cytochrom_C; pfam00034 526225008022 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 526225008023 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 526225008024 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 526225008025 iron-sulfur cluster [ion binding]; other site 526225008026 [2Fe-2S] cluster binding site [ion binding]; other site 526225008027 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 526225008028 heme bH binding site [chemical binding]; other site 526225008029 intrachain domain interface; other site 526225008030 heme bL binding site [chemical binding]; other site 526225008031 interchain domain interface [polypeptide binding]; other site 526225008032 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 526225008033 Qo binding site; other site 526225008034 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 526225008035 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 526225008036 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 526225008037 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 526225008038 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 526225008039 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 526225008040 active site 526225008041 dimer interface [polypeptide binding]; other site 526225008042 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 526225008043 Ligand Binding Site [chemical binding]; other site 526225008044 Molecular Tunnel; other site 526225008045 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 526225008046 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 526225008047 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225008048 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225008049 active site 526225008050 catalytic tetrad [active] 526225008051 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 526225008052 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 526225008053 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 526225008054 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 526225008055 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 526225008056 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 526225008057 multifunctional aminopeptidase A; Provisional; Region: PRK00913 526225008058 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 526225008059 interface (dimer of trimers) [polypeptide binding]; other site 526225008060 Substrate-binding/catalytic site; other site 526225008061 Zn-binding sites [ion binding]; other site 526225008062 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 526225008063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225008064 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526225008065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526225008066 E3 interaction surface; other site 526225008067 lipoyl attachment site [posttranslational modification]; other site 526225008068 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526225008069 E3 interaction surface; other site 526225008070 lipoyl attachment site [posttranslational modification]; other site 526225008071 e3 binding domain; Region: E3_binding; pfam02817 526225008072 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 526225008073 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 526225008074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225008075 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 526225008076 NAD(P) binding site [chemical binding]; other site 526225008077 active site 526225008078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225008079 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526225008080 active site 526225008081 ATP binding site [chemical binding]; other site 526225008082 substrate binding site [chemical binding]; other site 526225008083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526225008084 substrate binding site [chemical binding]; other site 526225008085 activation loop (A-loop); other site 526225008086 activation loop (A-loop); other site 526225008087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225008088 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 526225008089 active site pocket [active] 526225008090 oxyanion hole [active] 526225008091 catalytic triad [active] 526225008092 active site nucleophile [active] 526225008093 lipoate-protein ligase B; Provisional; Region: PRK14345 526225008094 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 526225008095 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225008096 active site 526225008097 HIGH motif; other site 526225008098 nucleotide binding site [chemical binding]; other site 526225008099 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 526225008100 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225008101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 526225008102 active site 526225008103 KMSKS motif; other site 526225008104 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 526225008105 tRNA binding surface [nucleotide binding]; other site 526225008106 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225008107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225008108 metal binding site [ion binding]; metal-binding site 526225008109 active site 526225008110 I-site; other site 526225008111 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225008112 lipoyl synthase; Provisional; Region: PRK05481 526225008113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225008114 FeS/SAM binding site; other site 526225008115 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 526225008116 RDD family; Region: RDD; pfam06271 526225008117 glutamine synthetase, type I; Region: GlnA; TIGR00653 526225008118 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 526225008119 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526225008120 hypothetical protein; Provisional; Region: PRK07208 526225008121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225008122 Protein of unknown function (DUF466); Region: DUF466; cl01082 526225008123 carbon starvation protein A; Provisional; Region: PRK15015 526225008124 Carbon starvation protein CstA; Region: CstA; pfam02554 526225008125 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 526225008126 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 526225008127 substrate binding site [chemical binding]; other site 526225008128 THF binding site; other site 526225008129 zinc-binding site [ion binding]; other site 526225008130 Uncharacterized conserved protein [Function unknown]; Region: COG3189 526225008131 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 526225008132 intersubunit interface [polypeptide binding]; other site 526225008133 active site 526225008134 Zn2+ binding site [ion binding]; other site 526225008135 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 526225008136 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 526225008137 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 526225008138 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526225008139 putative dimer interface [polypeptide binding]; other site 526225008140 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 526225008141 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 526225008142 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526225008143 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 526225008144 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 526225008145 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 526225008146 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 526225008147 FAD binding domain; Region: FAD_binding_4; pfam01565 526225008148 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 526225008149 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 526225008150 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 526225008151 putative active site [active] 526225008152 putative metal binding site [ion binding]; other site 526225008153 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 526225008154 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 526225008155 classical (c) SDRs; Region: SDR_c; cd05233 526225008156 NAD(P) binding site [chemical binding]; other site 526225008157 active site 526225008158 GAF domain; Region: GAF; cl17456 526225008159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526225008160 dimer interface [polypeptide binding]; other site 526225008161 putative CheW interface [polypeptide binding]; other site 526225008162 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 526225008163 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 526225008164 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 526225008165 metal binding triad; other site 526225008166 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 526225008167 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 526225008168 metal binding triad; other site 526225008169 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 526225008170 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 526225008171 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 526225008172 catalytic triad [active] 526225008173 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 526225008174 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 526225008175 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 526225008176 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 526225008177 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 526225008178 NAD synthetase; Provisional; Region: PRK13981 526225008179 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 526225008180 multimer interface [polypeptide binding]; other site 526225008181 active site 526225008182 catalytic triad [active] 526225008183 protein interface 1 [polypeptide binding]; other site 526225008184 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 526225008185 homodimer interface [polypeptide binding]; other site 526225008186 NAD binding pocket [chemical binding]; other site 526225008187 ATP binding pocket [chemical binding]; other site 526225008188 Mg binding site [ion binding]; other site 526225008189 active-site loop [active] 526225008190 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 526225008191 oligomerization interface [polypeptide binding]; other site 526225008192 active site 526225008193 metal binding site [ion binding]; metal-binding site 526225008194 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 526225008195 Cupin domain; Region: Cupin_2; pfam07883 526225008196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225008197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225008198 metal binding site [ion binding]; metal-binding site 526225008199 active site 526225008200 I-site; other site 526225008201 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 526225008202 active site 526225008203 short chain dehydrogenase; Provisional; Region: PRK07109 526225008204 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 526225008205 putative NAD(P) binding site [chemical binding]; other site 526225008206 active site 526225008207 TIR domain; Region: TIR_2; pfam13676 526225008208 ChaB; Region: ChaB; pfam06150 526225008209 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 526225008210 GAF domain; Region: GAF_2; pfam13185 526225008211 GAF domain; Region: GAF; cl17456 526225008212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225008213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225008214 metal binding site [ion binding]; metal-binding site 526225008215 active site 526225008216 I-site; other site 526225008217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225008218 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 526225008219 active site 526225008220 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 526225008221 peptide chain release factor 1; Provisional; Region: PRK04011 526225008222 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 526225008223 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 526225008224 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 526225008225 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 526225008226 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 526225008227 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 526225008228 ATP binding site [chemical binding]; other site 526225008229 Walker A motif; other site 526225008230 hexamer interface [polypeptide binding]; other site 526225008231 Walker B motif; other site 526225008232 AAA domain; Region: AAA_31; pfam13614 526225008233 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 526225008234 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 526225008235 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 526225008236 TadE-like protein; Region: TadE; pfam07811 526225008237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225008238 putative substrate translocation pore; other site 526225008239 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 526225008240 Uncharacterized conserved protein [Function unknown]; Region: COG0397 526225008241 hypothetical protein; Validated; Region: PRK00029 526225008242 GAF domain; Region: GAF; pfam01590 526225008243 ANTAR domain; Region: ANTAR; pfam03861 526225008244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225008245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225008246 Mg2+ binding site [ion binding]; other site 526225008247 G-X-G motif; other site 526225008248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225008249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225008250 active site 526225008251 phosphorylation site [posttranslational modification] 526225008252 intermolecular recognition site; other site 526225008253 dimerization interface [polypeptide binding]; other site 526225008254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225008255 DNA binding residues [nucleotide binding] 526225008256 dimerization interface [polypeptide binding]; other site 526225008257 Coenzyme A transferase; Region: CoA_trans; smart00882 526225008258 Coenzyme A transferase; Region: CoA_trans; cl17247 526225008259 Citrate transporter; Region: CitMHS; pfam03600 526225008260 fructuronate transporter; Provisional; Region: PRK10034; cl15264 526225008261 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 526225008262 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 526225008263 RibD C-terminal domain; Region: RibD_C; cl17279 526225008264 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526225008265 FOG: WD40 repeat [General function prediction only]; Region: COG2319 526225008266 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 526225008267 structural tetrad; other site 526225008268 FOG: WD40 repeat [General function prediction only]; Region: COG2319 526225008269 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 526225008270 structural tetrad; other site 526225008271 Lsr2; Region: Lsr2; pfam11774 526225008272 DDE superfamily endonuclease; Region: DDE_4; pfam13359 526225008273 TIR domain; Region: TIR_2; pfam13676 526225008274 FOG: WD40 repeat [General function prediction only]; Region: COG2319 526225008275 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526225008276 structural tetrad; other site 526225008277 FOG: WD40 repeat [General function prediction only]; Region: COG2319 526225008278 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526225008279 structural tetrad; other site 526225008280 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 526225008281 structural tetrad; other site 526225008282 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526225008283 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 526225008284 nucleoside/Zn binding site; other site 526225008285 dimer interface [polypeptide binding]; other site 526225008286 catalytic motif [active] 526225008287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 526225008288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225008289 S-adenosylmethionine binding site [chemical binding]; other site 526225008290 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225008291 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 526225008292 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 526225008293 quinolinate synthetase; Provisional; Region: PRK09375 526225008294 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 526225008295 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 526225008296 RNA/DNA hybrid binding site [nucleotide binding]; other site 526225008297 active site 526225008298 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225008299 catalytic core [active] 526225008300 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 526225008301 Putative zinc ribbon domain; Region: DUF164; pfam02591 526225008302 Uncharacterized conserved protein [Function unknown]; Region: COG0327 526225008303 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 526225008304 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 526225008305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225008306 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225008307 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225008308 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 526225008309 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 526225008310 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 526225008311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225008312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225008313 NAD(P) binding site [chemical binding]; other site 526225008314 active site 526225008315 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225008316 Serine hydrolase; Region: Ser_hydrolase; cl17834 526225008317 Secretory lipase; Region: LIP; pfam03583 526225008318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225008319 PGAP1-like protein; Region: PGAP1; pfam07819 526225008320 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225008321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225008322 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 526225008323 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225008324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526225008325 TPR motif; other site 526225008326 binding surface 526225008327 TPR repeat; Region: TPR_11; pfam13414 526225008328 TIR domain; Region: TIR_2; pfam13676 526225008329 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 526225008330 SIR2-like domain; Region: SIR2_2; pfam13289 526225008331 TIR domain; Region: TIR_2; pfam13676 526225008332 NB-ARC domain; Region: NB-ARC; pfam00931 526225008333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526225008334 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526225008335 binding surface 526225008336 TPR motif; other site 526225008337 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526225008338 Tetratricopeptide repeat; Region: TPR_12; pfam13424 526225008339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 526225008340 TPR motif; other site 526225008341 binding surface 526225008342 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 526225008343 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 526225008344 Protein of unknown function DUF262; Region: DUF262; pfam03235 526225008345 Uncharacterized conserved protein [Function unknown]; Region: COG1479 526225008346 Protein of unknown function DUF262; Region: DUF262; pfam03235 526225008347 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 526225008348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225008349 salt bridge; other site 526225008350 non-specific DNA binding site [nucleotide binding]; other site 526225008351 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225008352 sequence-specific DNA binding site [nucleotide binding]; other site 526225008353 short chain dehydrogenase; Provisional; Region: PRK06180 526225008354 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 526225008355 NADP binding site [chemical binding]; other site 526225008356 active site 526225008357 steroid binding site; other site 526225008358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225008359 active site 526225008360 Int/Topo IB signature motif; other site 526225008361 DNA binding site [nucleotide binding] 526225008362 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 526225008363 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 526225008364 dimer interface [polypeptide binding]; other site 526225008365 catalytic triad [active] 526225008366 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 526225008367 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 526225008368 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 526225008369 dimer interface [polypeptide binding]; other site 526225008370 TPP-binding site [chemical binding]; other site 526225008371 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 526225008372 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225008373 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 526225008374 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 526225008375 metal binding site [ion binding]; metal-binding site 526225008376 dimer interface [polypeptide binding]; other site 526225008377 Pirin; Region: Pirin; pfam02678 526225008378 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 526225008379 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 526225008380 active site 526225008381 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225008382 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 526225008383 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 526225008384 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 526225008385 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526225008386 carboxyltransferase (CT) interaction site; other site 526225008387 biotinylation site [posttranslational modification]; other site 526225008388 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 526225008389 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 526225008390 dimer interface [polypeptide binding]; other site 526225008391 active site 526225008392 CoA binding pocket [chemical binding]; other site 526225008393 acyl carrier protein; Provisional; Region: acpP; PRK00982 526225008394 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 526225008395 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 526225008396 dimer interface [polypeptide binding]; other site 526225008397 active site 526225008398 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 526225008399 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 526225008400 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 526225008401 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225008402 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225008403 metal binding site [ion binding]; metal-binding site 526225008404 active site 526225008405 I-site; other site 526225008406 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225008407 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526225008408 Peptidase family M23; Region: Peptidase_M23; pfam01551 526225008409 PBP superfamily domain; Region: PBP_like_2; cl17296 526225008410 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 526225008411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225008412 active site 526225008413 DNA binding site [nucleotide binding] 526225008414 Int/Topo IB signature motif; other site 526225008415 Helix-turn-helix domain; Region: HTH_17; pfam12728 526225008416 stage V sporulation protein K; Region: spore_V_K; TIGR02881 526225008417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225008418 Walker A motif; other site 526225008419 ATP binding site [chemical binding]; other site 526225008420 Walker B motif; other site 526225008421 arginine finger; other site 526225008422 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 526225008423 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 526225008424 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 526225008425 Transposase; Region: DEDD_Tnp_IS110; pfam01548 526225008426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 526225008427 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 526225008428 DDE superfamily endonuclease; Region: DDE_5; pfam13546 526225008429 DDE superfamily endonuclease; Region: DDE_4; pfam13359 526225008430 Homeodomain-like domain; Region: HTH_23; pfam13384 526225008431 Winged helix-turn helix; Region: HTH_29; pfam13551 526225008432 Homeodomain-like domain; Region: HTH_32; pfam13565 526225008433 DDE superfamily endonuclease; Region: DDE_3; pfam13358 526225008434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 526225008435 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 526225008436 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 526225008437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225008438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225008439 active site 526225008440 catalytic tetrad [active] 526225008441 Cupin domain; Region: Cupin_2; cl17218 526225008442 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 526225008443 putative hydrophobic ligand binding site [chemical binding]; other site 526225008444 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225008445 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 526225008446 putative NAD(P) binding site [chemical binding]; other site 526225008447 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 526225008448 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225008449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225008450 Walker A/P-loop; other site 526225008451 ATP binding site [chemical binding]; other site 526225008452 Q-loop/lid; other site 526225008453 ABC transporter signature motif; other site 526225008454 Walker B; other site 526225008455 D-loop; other site 526225008456 H-loop/switch region; other site 526225008457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225008458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225008459 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 526225008460 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225008461 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 526225008462 putative NAD(P) binding site [chemical binding]; other site 526225008463 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225008464 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 526225008465 catalytic site [active] 526225008466 DDE superfamily endonuclease; Region: DDE_4; pfam13359 526225008467 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 526225008468 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 526225008469 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 526225008470 VanW like protein; Region: VanW; pfam04294 526225008471 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 526225008472 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 526225008473 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 526225008474 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526225008475 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 526225008476 ATP binding site [chemical binding]; other site 526225008477 substrate binding site [chemical binding]; other site 526225008478 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 526225008479 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 526225008480 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 526225008481 putative active site [active] 526225008482 dimerization interface [polypeptide binding]; other site 526225008483 putative tRNAtyr binding site [nucleotide binding]; other site 526225008484 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 526225008485 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 526225008486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225008487 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526225008488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225008489 DNA binding residues [nucleotide binding] 526225008490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526225008491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225008492 Coenzyme A binding pocket [chemical binding]; other site 526225008493 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 526225008494 CoA binding domain; Region: CoA_binding_2; pfam13380 526225008495 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 526225008496 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 526225008497 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 526225008498 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 526225008499 active site 526225008500 Zn binding site [ion binding]; other site 526225008501 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 526225008502 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 526225008503 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 526225008504 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 526225008505 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 526225008506 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225008507 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 526225008508 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 526225008509 catalytic residues [active] 526225008510 catalytic nucleophile [active] 526225008511 Recombinase; Region: Recombinase; pfam07508 526225008512 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 526225008513 Helix-turn-helix domain; Region: HTH_36; pfam13730 526225008514 Phage capsid family; Region: Phage_capsid; pfam05065 526225008515 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 526225008516 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 526225008517 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 526225008518 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 526225008519 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 526225008520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 526225008521 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 526225008522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225008523 S-adenosylmethionine binding site [chemical binding]; other site 526225008524 Protein of unknown function, DUF608; Region: DUF608; pfam04685 526225008525 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225008526 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526225008527 Probable Catalytic site; other site 526225008528 metal-binding site 526225008529 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225008530 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526225008531 Probable Catalytic site; other site 526225008532 metal-binding site 526225008533 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 526225008534 Methyltransferase domain; Region: Methyltransf_24; pfam13578 526225008535 YibE/F-like protein; Region: YibE_F; pfam07907 526225008536 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225008537 anti sigma factor interaction site; other site 526225008538 regulatory phosphorylation site [posttranslational modification]; other site 526225008539 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 526225008540 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 526225008541 putative dimer interface [polypeptide binding]; other site 526225008542 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 526225008543 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225008544 DNA binding residues [nucleotide binding] 526225008545 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 526225008546 putative homodimer interface [polypeptide binding]; other site 526225008547 putative homotetramer interface [polypeptide binding]; other site 526225008548 putative allosteric switch controlling residues; other site 526225008549 putative metal binding site [ion binding]; other site 526225008550 putative homodimer-homodimer interface [polypeptide binding]; other site 526225008551 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526225008552 metal-binding site [ion binding] 526225008553 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 526225008554 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526225008555 metal-binding site [ion binding] 526225008556 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526225008557 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 526225008558 Epoxide hydrolase N terminus; Region: EHN; pfam06441 526225008559 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225008560 Penicillinase repressor; Region: Pencillinase_R; cl17580 526225008561 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 526225008562 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 526225008563 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 526225008564 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 526225008565 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 526225008566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225008567 Walker A/P-loop; other site 526225008568 ATP binding site [chemical binding]; other site 526225008569 Q-loop/lid; other site 526225008570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225008571 Walker A/P-loop; other site 526225008572 ATP binding site [chemical binding]; other site 526225008573 Q-loop/lid; other site 526225008574 ABC transporter signature motif; other site 526225008575 Walker B; other site 526225008576 D-loop; other site 526225008577 H-loop/switch region; other site 526225008578 RibD C-terminal domain; Region: RibD_C; cl17279 526225008579 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 526225008580 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 526225008581 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 526225008582 tartrate dehydrogenase; Region: TTC; TIGR02089 526225008583 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 526225008584 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 526225008585 NAD(P) binding site [chemical binding]; other site 526225008586 catalytic residues [active] 526225008587 Cupin domain; Region: Cupin_2; pfam07883 526225008588 Uncharacterized conserved protein [Function unknown]; Region: COG1359 526225008589 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 526225008590 Transcriptional regulators [Transcription]; Region: GntR; COG1802 526225008591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225008592 DNA-binding site [nucleotide binding]; DNA binding site 526225008593 FCD domain; Region: FCD; pfam07729 526225008594 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225008595 Ligand Binding Site [chemical binding]; other site 526225008596 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 526225008597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225008598 intermolecular recognition site; other site 526225008599 active site 526225008600 dimerization interface [polypeptide binding]; other site 526225008601 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 526225008602 PAS domain; Region: PAS; smart00091 526225008603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225008604 ATP binding site [chemical binding]; other site 526225008605 Mg2+ binding site [ion binding]; other site 526225008606 G-X-G motif; other site 526225008607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 526225008608 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 526225008609 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 526225008610 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 526225008611 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 526225008612 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 526225008613 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 526225008614 ethanolamine permease; Region: 2A0305; TIGR00908 526225008615 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225008616 GAF domain; Region: GAF; pfam01590 526225008617 ANTAR domain; Region: ANTAR; pfam03861 526225008618 classical (c) SDRs; Region: SDR_c; cd05233 526225008619 NAD(P) binding site [chemical binding]; other site 526225008620 active site 526225008621 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526225008622 putative active site [active] 526225008623 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 526225008624 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 526225008625 putative active site [active] 526225008626 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526225008627 active site 526225008628 dimer interface [polypeptide binding]; other site 526225008629 motif 2; other site 526225008630 motif 3; other site 526225008631 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 526225008632 Domain of unknown function (DUF222); Region: DUF222; pfam02720 526225008633 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526225008634 active site 526225008635 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225008636 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225008637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225008638 NAD(P) binding site [chemical binding]; other site 526225008639 active site 526225008640 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 526225008641 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526225008642 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 526225008643 Walker A/P-loop; other site 526225008644 ATP binding site [chemical binding]; other site 526225008645 Q-loop/lid; other site 526225008646 ABC transporter signature motif; other site 526225008647 Walker B; other site 526225008648 D-loop; other site 526225008649 H-loop/switch region; other site 526225008650 TOBE domain; Region: TOBE_2; pfam08402 526225008651 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 526225008652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225008653 dimer interface [polypeptide binding]; other site 526225008654 conserved gate region; other site 526225008655 ABC-ATPase subunit interface; other site 526225008656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225008657 dimer interface [polypeptide binding]; other site 526225008658 conserved gate region; other site 526225008659 ABC-ATPase subunit interface; other site 526225008660 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 526225008661 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 526225008662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 526225008663 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 526225008664 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 526225008665 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 526225008666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225008667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 526225008668 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 526225008669 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225008670 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526225008671 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 526225008672 CoenzymeA binding site [chemical binding]; other site 526225008673 subunit interaction site [polypeptide binding]; other site 526225008674 PHB binding site; other site 526225008675 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526225008676 FAD binding domain; Region: FAD_binding_4; pfam01565 526225008677 Berberine and berberine like; Region: BBE; pfam08031 526225008678 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526225008679 nudix motif; other site 526225008680 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526225008681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225008682 substrate binding site [chemical binding]; other site 526225008683 oxyanion hole (OAH) forming residues; other site 526225008684 trimer interface [polypeptide binding]; other site 526225008685 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 526225008686 Part of AAA domain; Region: AAA_19; pfam13245 526225008687 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 526225008688 AAA domain; Region: AAA_12; pfam13087 526225008689 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 526225008690 homotetrameric interface [polypeptide binding]; other site 526225008691 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 526225008692 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225008693 active site 526225008694 ATP binding site [chemical binding]; other site 526225008695 substrate binding site [chemical binding]; other site 526225008696 activation loop (A-loop); other site 526225008697 PAS fold; Region: PAS_2; pfam08446 526225008698 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225008699 GAF domain; Region: GAF; pfam01590 526225008700 Phytochrome region; Region: PHY; pfam00360 526225008701 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225008702 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225008703 anti sigma factor interaction site; other site 526225008704 regulatory phosphorylation site [posttranslational modification]; other site 526225008705 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225008706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 526225008707 ATP binding site [chemical binding]; other site 526225008708 Mg2+ binding site [ion binding]; other site 526225008709 G-X-G motif; other site 526225008710 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225008711 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225008712 active site 526225008713 ATP binding site [chemical binding]; other site 526225008714 substrate binding site [chemical binding]; other site 526225008715 activation loop (A-loop); other site 526225008716 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 526225008717 hypothetical protein; Reviewed; Region: PRK09588 526225008718 Cupin domain; Region: Cupin_2; pfam07883 526225008719 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225008720 anti sigma factor interaction site; other site 526225008721 regulatory phosphorylation site [posttranslational modification]; other site 526225008722 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 526225008723 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 526225008724 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 526225008725 Strictosidine synthase; Region: Str_synth; pfam03088 526225008726 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 526225008727 dimerization interface [polypeptide binding]; other site 526225008728 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 526225008729 NAD binding site [chemical binding]; other site 526225008730 ligand binding site [chemical binding]; other site 526225008731 catalytic site [active] 526225008732 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 526225008733 nudix motif; other site 526225008734 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 526225008735 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 526225008736 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 526225008737 active site 526225008738 catalytic residues [active] 526225008739 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 526225008740 HD domain; Region: HD_4; pfam13328 526225008741 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526225008742 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 526225008743 substrate binding site [chemical binding]; other site 526225008744 ATP binding site [chemical binding]; other site 526225008745 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 526225008746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225008747 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 526225008748 oligomeric interface; other site 526225008749 putative active site [active] 526225008750 homodimer interface [polypeptide binding]; other site 526225008751 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 526225008752 RNase_H superfamily; Region: RNase_H_2; pfam13482 526225008753 AAA domain; Region: AAA_30; pfam13604 526225008754 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 526225008755 AAA domain; Region: AAA_12; pfam13087 526225008756 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 526225008757 putative active site [active] 526225008758 homotetrameric interface [polypeptide binding]; other site 526225008759 metal binding site [ion binding]; metal-binding site 526225008760 Cupin domain; Region: Cupin_2; cl17218 526225008761 Domain of unknown function (DUF385); Region: DUF385; cl04387 526225008762 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 526225008763 putative catalytic site [active] 526225008764 putative metal binding site [ion binding]; other site 526225008765 putative phosphate binding site [ion binding]; other site 526225008766 Cupin domain; Region: Cupin_2; pfam07883 526225008767 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 526225008768 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 526225008769 NAD binding site [chemical binding]; other site 526225008770 substrate binding site [chemical binding]; other site 526225008771 catalytic Zn binding site [ion binding]; other site 526225008772 structural Zn binding site [ion binding]; other site 526225008773 Cupin domain; Region: Cupin_2; cl17218 526225008774 PemK-like protein; Region: PemK; pfam02452 526225008775 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 526225008776 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 526225008777 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 526225008778 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 526225008779 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 526225008780 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 526225008781 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225008782 putative Zn2+ binding site [ion binding]; other site 526225008783 putative DNA binding site [nucleotide binding]; other site 526225008784 dimerization interface [polypeptide binding]; other site 526225008785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 526225008786 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 526225008787 Fic/DOC family; Region: Fic; cl00960 526225008788 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 526225008789 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526225008790 active site 526225008791 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 526225008792 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 526225008793 putative catalytic site [active] 526225008794 putative metal binding site [ion binding]; other site 526225008795 putative phosphate binding site [ion binding]; other site 526225008796 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 526225008797 PLD-like domain; Region: PLDc_2; pfam13091 526225008798 putative homodimer interface [polypeptide binding]; other site 526225008799 putative active site [active] 526225008800 catalytic site [active] 526225008801 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 526225008802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225008803 ATP binding site [chemical binding]; other site 526225008804 putative Mg++ binding site [ion binding]; other site 526225008805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225008806 nucleotide binding region [chemical binding]; other site 526225008807 ATP-binding site [chemical binding]; other site 526225008808 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 526225008809 Part of AAA domain; Region: AAA_19; pfam13245 526225008810 Family description; Region: UvrD_C_2; pfam13538 526225008811 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 526225008812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225008813 ATP binding site [chemical binding]; other site 526225008814 putative Mg++ binding site [ion binding]; other site 526225008815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225008816 ATP-binding site [chemical binding]; other site 526225008817 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 526225008818 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 526225008819 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 526225008820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225008821 ATP binding site [chemical binding]; other site 526225008822 putative Mg++ binding site [ion binding]; other site 526225008823 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225008824 nucleotide binding region [chemical binding]; other site 526225008825 ATP-binding site [chemical binding]; other site 526225008826 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 526225008827 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 526225008828 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 526225008829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225008830 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 526225008831 acyl-activating enzyme (AAE) consensus motif; other site 526225008832 acyl-activating enzyme (AAE) consensus motif; other site 526225008833 putative AMP binding site [chemical binding]; other site 526225008834 putative active site [active] 526225008835 putative CoA binding site [chemical binding]; other site 526225008836 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 526225008837 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 526225008838 PAS domain S-box; Region: sensory_box; TIGR00229 526225008839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225008840 putative active site [active] 526225008841 heme pocket [chemical binding]; other site 526225008842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225008843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225008844 metal binding site [ion binding]; metal-binding site 526225008845 active site 526225008846 I-site; other site 526225008847 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225008848 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 526225008849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225008850 S-adenosylmethionine binding site [chemical binding]; other site 526225008851 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 526225008852 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 526225008853 putative active site [active] 526225008854 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 526225008855 ABC1 family; Region: ABC1; pfam03109 526225008856 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 526225008857 active site 526225008858 ATP binding site [chemical binding]; other site 526225008859 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 526225008860 FMN binding site [chemical binding]; other site 526225008861 substrate binding site [chemical binding]; other site 526225008862 putative catalytic residue [active] 526225008863 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 526225008864 Uncharacterized conserved protein [Function unknown]; Region: COG3391 526225008865 Fic family protein [Function unknown]; Region: COG3177 526225008866 Fic/DOC family; Region: Fic; pfam02661 526225008867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225008868 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225008869 TIGR03086 family protein; Region: TIGR03086 526225008870 Transglycosylase; Region: Transgly; pfam00912 526225008871 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 526225008872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225008873 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225008874 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225008875 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225008876 active site 526225008877 enoyl-CoA hydratase; Provisional; Region: PRK05870 526225008878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225008879 substrate binding site [chemical binding]; other site 526225008880 oxyanion hole (OAH) forming residues; other site 526225008881 trimer interface [polypeptide binding]; other site 526225008882 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 526225008883 CoA binding domain; Region: CoA_binding_2; pfam13380 526225008884 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 526225008885 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 526225008886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225008887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225008888 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 526225008889 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 526225008890 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 526225008891 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 526225008892 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 526225008893 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 526225008894 putative NAD(P) binding site [chemical binding]; other site 526225008895 putative active site [active] 526225008896 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 526225008897 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 526225008898 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 526225008899 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 526225008900 inhibitor site; inhibition site 526225008901 active site 526225008902 dimer interface [polypeptide binding]; other site 526225008903 catalytic residue [active] 526225008904 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526225008905 Predicted dehydrogenase [General function prediction only]; Region: COG0579 526225008906 Domain of unknown function (DUF222); Region: DUF222; pfam02720 526225008907 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526225008908 active site 526225008909 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 526225008910 hypothetical protein; Validated; Region: PRK06201 526225008911 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 526225008912 tartrate dehydrogenase; Provisional; Region: PRK08194 526225008913 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 526225008914 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 526225008915 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 526225008916 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 526225008917 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 526225008918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225008919 DNA-binding site [nucleotide binding]; DNA binding site 526225008920 Transcriptional regulators [Transcription]; Region: FadR; COG2186 526225008921 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 526225008922 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 526225008923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225008924 NAD(P) binding site [chemical binding]; other site 526225008925 active site 526225008926 monocarboxylate transporter 1; Region: 2A0113; TIGR00892 526225008927 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 526225008928 CoA-transferase family III; Region: CoA_transf_3; pfam02515 526225008929 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 526225008930 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 526225008931 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 526225008932 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 526225008933 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 526225008934 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 526225008935 putative dimer interface [polypeptide binding]; other site 526225008936 N-terminal domain interface [polypeptide binding]; other site 526225008937 putative substrate binding pocket (H-site) [chemical binding]; other site 526225008938 Excalibur calcium-binding domain; Region: Excalibur; smart00894 526225008939 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 526225008940 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 526225008941 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 526225008942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225008943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225008944 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225008945 active site 526225008946 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225008947 PAS domain; Region: PAS_9; pfam13426 526225008948 putative active site [active] 526225008949 heme pocket [chemical binding]; other site 526225008950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225008951 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225008952 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225008953 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225008954 Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB...; Region: CYCLIN; cl00050 526225008955 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 526225008956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225008957 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 526225008958 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 526225008959 Part of AAA domain; Region: AAA_19; pfam13245 526225008960 Family description; Region: UvrD_C_2; pfam13538 526225008961 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225008962 Cytochrome P450; Region: p450; cl12078 526225008963 SIR2-like domain; Region: SIR2_2; pfam13289 526225008964 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 526225008965 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 526225008966 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 526225008967 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 526225008968 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 526225008969 Predicted membrane protein [Function unknown]; Region: COG4325 526225008970 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 526225008971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225008972 NAD(P) binding site [chemical binding]; other site 526225008973 active site 526225008974 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 526225008975 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526225008976 dimer interface [polypeptide binding]; other site 526225008977 active site 526225008978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225008979 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 526225008980 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 526225008981 ligand binding site [chemical binding]; other site 526225008982 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 526225008983 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 526225008984 TM-ABC transporter signature motif; other site 526225008985 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 526225008986 TM-ABC transporter signature motif; other site 526225008987 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 526225008988 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 526225008989 Walker A/P-loop; other site 526225008990 ATP binding site [chemical binding]; other site 526225008991 Q-loop/lid; other site 526225008992 ABC transporter signature motif; other site 526225008993 Walker B; other site 526225008994 D-loop; other site 526225008995 H-loop/switch region; other site 526225008996 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 526225008997 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 526225008998 Walker A/P-loop; other site 526225008999 ATP binding site [chemical binding]; other site 526225009000 Q-loop/lid; other site 526225009001 ABC transporter signature motif; other site 526225009002 Walker B; other site 526225009003 D-loop; other site 526225009004 H-loop/switch region; other site 526225009005 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225009006 anti sigma factor interaction site; other site 526225009007 regulatory phosphorylation site [posttranslational modification]; other site 526225009008 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 526225009009 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 526225009010 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526225009011 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 526225009012 NAD(P) binding site [chemical binding]; other site 526225009013 catalytic residues [active] 526225009014 choline dehydrogenase; Validated; Region: PRK02106 526225009015 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 526225009016 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225009017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225009018 putative substrate translocation pore; other site 526225009019 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 526225009020 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 526225009021 conserved cys residue [active] 526225009022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225009023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 526225009024 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526225009025 ATP binding site [chemical binding]; other site 526225009026 putative Mg++ binding site [ion binding]; other site 526225009027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225009028 nucleotide binding region [chemical binding]; other site 526225009029 ATP-binding site [chemical binding]; other site 526225009030 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 526225009031 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526225009032 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 526225009033 Metal-binding active site; metal-binding site 526225009034 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 526225009035 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225009036 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225009037 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 526225009038 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 526225009039 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 526225009040 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225009041 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 526225009042 TM-ABC transporter signature motif; other site 526225009043 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 526225009044 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526225009045 Walker A/P-loop; other site 526225009046 ATP binding site [chemical binding]; other site 526225009047 Q-loop/lid; other site 526225009048 ABC transporter signature motif; other site 526225009049 Walker B; other site 526225009050 D-loop; other site 526225009051 H-loop/switch region; other site 526225009052 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 526225009053 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 526225009054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 526225009055 nucleotide binding site [chemical binding]; other site 526225009056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225009057 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 526225009058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225009059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225009060 putative hydrolase; Provisional; Region: PRK11460 526225009061 Predicted esterase [General function prediction only]; Region: COG0400 526225009062 Erythromycin esterase; Region: Erythro_esteras; pfam05139 526225009063 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 526225009064 classical (c) SDRs; Region: SDR_c; cd05233 526225009065 NAD(P) binding site [chemical binding]; other site 526225009066 active site 526225009067 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 526225009068 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 526225009069 trehalose synthase; Region: treS_nterm; TIGR02456 526225009070 active site 526225009071 catalytic site [active] 526225009072 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 526225009073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526225009074 protein binding site [polypeptide binding]; other site 526225009075 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225009076 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225009077 metal binding site [ion binding]; metal-binding site 526225009078 active site 526225009079 I-site; other site 526225009080 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 526225009081 oxidoreductase; Provisional; Region: PRK12743 526225009082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225009083 NAD(P) binding site [chemical binding]; other site 526225009084 active site 526225009085 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 526225009086 HTH domain; Region: HTH_11; cl17392 526225009087 WYL domain; Region: WYL; pfam13280 526225009088 Protein of unknown function (DUF664); Region: DUF664; pfam04978 526225009089 DinB superfamily; Region: DinB_2; pfam12867 526225009090 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 526225009091 putative hydrophobic ligand binding site [chemical binding]; other site 526225009092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225009093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225009094 active site 526225009095 catalytic tetrad [active] 526225009096 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 526225009097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225009098 RibD C-terminal domain; Region: RibD_C; cl17279 526225009099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225009100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225009101 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 526225009102 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 526225009103 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 526225009104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225009105 Coenzyme A binding pocket [chemical binding]; other site 526225009106 Uncharacterized conserved protein [Function unknown]; Region: COG4095 526225009107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225009108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225009109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225009110 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526225009111 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 526225009112 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526225009113 metal-binding site [ion binding] 526225009114 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 526225009115 Soluble P-type ATPase [General function prediction only]; Region: COG4087 526225009116 YtkA-like; Region: YtkA; pfam13115 526225009117 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526225009118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225009119 Coenzyme A binding pocket [chemical binding]; other site 526225009120 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 526225009121 metal-binding site [ion binding] 526225009122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225009123 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 526225009124 putative substrate translocation pore; other site 526225009125 AAA ATPase domain; Region: AAA_16; pfam13191 526225009126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225009127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225009128 DNA binding residues [nucleotide binding] 526225009129 dimerization interface [polypeptide binding]; other site 526225009130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225009131 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 526225009132 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 526225009133 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 526225009134 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 526225009135 active site 526225009136 dimer interface [polypeptide binding]; other site 526225009137 effector binding site; other site 526225009138 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 526225009139 TSCPD domain; Region: TSCPD; pfam12637 526225009140 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 526225009141 ATP cone domain; Region: ATP-cone; pfam03477 526225009142 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 526225009143 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 526225009144 LexA repressor; Validated; Region: PRK00215 526225009145 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 526225009146 Catalytic site [active] 526225009147 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 526225009148 active site 526225009149 GTPases [General function prediction only]; Region: HflX; COG2262 526225009150 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 526225009151 HflX GTPase family; Region: HflX; cd01878 526225009152 G1 box; other site 526225009153 GTP/Mg2+ binding site [chemical binding]; other site 526225009154 Switch I region; other site 526225009155 G2 box; other site 526225009156 G3 box; other site 526225009157 Switch II region; other site 526225009158 G4 box; other site 526225009159 G5 box; other site 526225009160 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 526225009161 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 526225009162 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 526225009163 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 526225009164 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 526225009165 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 526225009166 active site 526225009167 metal binding site [ion binding]; metal-binding site 526225009168 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 526225009169 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 526225009170 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 526225009171 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 526225009172 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 526225009173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225009174 FeS/SAM binding site; other site 526225009175 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 526225009176 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 526225009177 Walker A/P-loop; other site 526225009178 ATP binding site [chemical binding]; other site 526225009179 Q-loop/lid; other site 526225009180 ABC transporter signature motif; other site 526225009181 Walker B; other site 526225009182 D-loop; other site 526225009183 H-loop/switch region; other site 526225009184 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 526225009185 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 526225009186 substrate binding pocket [chemical binding]; other site 526225009187 membrane-bound complex binding site; other site 526225009188 hinge residues; other site 526225009189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225009190 dimer interface [polypeptide binding]; other site 526225009191 conserved gate region; other site 526225009192 putative PBP binding loops; other site 526225009193 ABC-ATPase subunit interface; other site 526225009194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225009195 dimer interface [polypeptide binding]; other site 526225009196 conserved gate region; other site 526225009197 putative PBP binding loops; other site 526225009198 ABC-ATPase subunit interface; other site 526225009199 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 526225009200 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 526225009201 D-pathway; other site 526225009202 Putative ubiquinol binding site [chemical binding]; other site 526225009203 Low-spin heme (heme b) binding site [chemical binding]; other site 526225009204 Putative water exit pathway; other site 526225009205 Binuclear center (heme o3/CuB) [ion binding]; other site 526225009206 K-pathway; other site 526225009207 Putative proton exit pathway; other site 526225009208 recombination regulator RecX; Reviewed; Region: recX; PRK00117 526225009209 recombinase A; Provisional; Region: recA; PRK09354 526225009210 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 526225009211 hexamer interface [polypeptide binding]; other site 526225009212 Walker A motif; other site 526225009213 ATP binding site [chemical binding]; other site 526225009214 Walker B motif; other site 526225009215 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 526225009216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225009217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225009218 active site 526225009219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225009220 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 526225009221 ATP binding site [chemical binding]; other site 526225009222 putative Mg++ binding site [ion binding]; other site 526225009223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225009224 nucleotide binding region [chemical binding]; other site 526225009225 ATP-binding site [chemical binding]; other site 526225009226 DEAD/H associated; Region: DEAD_assoc; pfam08494 526225009227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 526225009228 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 526225009229 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 526225009230 putative DNA binding site [nucleotide binding]; other site 526225009231 catalytic residue [active] 526225009232 putative H2TH interface [polypeptide binding]; other site 526225009233 putative catalytic residues [active] 526225009234 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 526225009235 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 526225009236 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 526225009237 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 526225009238 substrate binding site [chemical binding]; other site 526225009239 ATP binding site [chemical binding]; other site 526225009240 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 526225009241 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 526225009242 Walker A/P-loop; other site 526225009243 ATP binding site [chemical binding]; other site 526225009244 Q-loop/lid; other site 526225009245 ABC transporter signature motif; other site 526225009246 Walker B; other site 526225009247 D-loop; other site 526225009248 H-loop/switch region; other site 526225009249 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 526225009250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225009251 dimer interface [polypeptide binding]; other site 526225009252 conserved gate region; other site 526225009253 ABC-ATPase subunit interface; other site 526225009254 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 526225009255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225009256 dimer interface [polypeptide binding]; other site 526225009257 conserved gate region; other site 526225009258 putative PBP binding loops; other site 526225009259 ABC-ATPase subunit interface; other site 526225009260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 526225009261 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 526225009262 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 526225009263 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 526225009264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225009265 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 526225009266 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 526225009267 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 526225009268 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225009269 FeS/SAM binding site; other site 526225009270 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 526225009271 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 526225009272 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 526225009273 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 526225009274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225009275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225009276 DNA binding residues [nucleotide binding] 526225009277 Putative zinc-finger; Region: zf-HC2; pfam13490 526225009278 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 526225009279 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225009280 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 526225009281 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 526225009282 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 526225009283 dimer interface [polypeptide binding]; other site 526225009284 active site 526225009285 catalytic residue [active] 526225009286 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 526225009287 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 526225009288 folate binding site [chemical binding]; other site 526225009289 NADP+ binding site [chemical binding]; other site 526225009290 thymidylate synthase; Reviewed; Region: thyA; PRK01827 526225009291 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 526225009292 dimerization interface [polypeptide binding]; other site 526225009293 active site 526225009294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 526225009295 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 526225009296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225009297 Coenzyme A binding pocket [chemical binding]; other site 526225009298 dihydrodipicolinate reductase; Provisional; Region: PRK00048 526225009299 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 526225009300 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 526225009301 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526225009302 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526225009303 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526225009304 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 526225009305 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 526225009306 RNase E interface [polypeptide binding]; other site 526225009307 trimer interface [polypeptide binding]; other site 526225009308 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 526225009309 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 526225009310 RNase E interface [polypeptide binding]; other site 526225009311 trimer interface [polypeptide binding]; other site 526225009312 active site 526225009313 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 526225009314 putative nucleic acid binding region [nucleotide binding]; other site 526225009315 G-X-X-G motif; other site 526225009316 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 526225009317 RNA binding site [nucleotide binding]; other site 526225009318 domain interface; other site 526225009319 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 526225009320 16S/18S rRNA binding site [nucleotide binding]; other site 526225009321 S13e-L30e interaction site [polypeptide binding]; other site 526225009322 25S rRNA binding site [nucleotide binding]; other site 526225009323 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 526225009324 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 526225009325 active site 526225009326 Riboflavin kinase; Region: Flavokinase; pfam01687 526225009327 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 526225009328 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 526225009329 homodimer interface [polypeptide binding]; other site 526225009330 substrate-cofactor binding pocket; other site 526225009331 catalytic residue [active] 526225009332 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 526225009333 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 526225009334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225009335 motif II; other site 526225009336 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 526225009337 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 526225009338 RNA binding site [nucleotide binding]; other site 526225009339 active site 526225009340 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 526225009341 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 526225009342 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 526225009343 DHH family; Region: DHH; pfam01368 526225009344 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 526225009345 Protein of unknown function (DUF503); Region: DUF503; pfam04456 526225009346 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 526225009347 translation initiation factor IF-2; Region: IF-2; TIGR00487 526225009348 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 526225009349 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 526225009350 G1 box; other site 526225009351 putative GEF interaction site [polypeptide binding]; other site 526225009352 GTP/Mg2+ binding site [chemical binding]; other site 526225009353 Switch I region; other site 526225009354 G2 box; other site 526225009355 G3 box; other site 526225009356 Switch II region; other site 526225009357 G4 box; other site 526225009358 G5 box; other site 526225009359 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 526225009360 Translation-initiation factor 2; Region: IF-2; pfam11987 526225009361 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 526225009362 NusA N-terminal domain; Region: NusA_N; pfam08529 526225009363 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 526225009364 RNA binding site [nucleotide binding]; other site 526225009365 homodimer interface [polypeptide binding]; other site 526225009366 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 526225009367 putative RNA binding cleft [nucleotide binding]; other site 526225009368 Sm and related proteins; Region: Sm_like; cl00259 526225009369 ribosome maturation protein RimP; Reviewed; Region: PRK00092 526225009370 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 526225009371 putative oligomer interface [polypeptide binding]; other site 526225009372 putative RNA binding site [nucleotide binding]; other site 526225009373 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 526225009374 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 526225009375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 526225009376 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 526225009377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225009378 Coenzyme A binding pocket [chemical binding]; other site 526225009379 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 526225009380 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 526225009381 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 526225009382 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 526225009383 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 526225009384 active site 526225009385 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 526225009386 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 526225009387 putative substrate binding region [chemical binding]; other site 526225009388 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 526225009389 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 526225009390 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 526225009391 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 526225009392 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 526225009393 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 526225009394 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 526225009395 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 526225009396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225009397 FeS/SAM binding site; other site 526225009398 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 526225009399 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 526225009400 RNA polymerase factor sigma-70; Validated; Region: PRK08241 526225009401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225009402 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 526225009403 SnoaL-like domain; Region: SnoaL_2; pfam12680 526225009404 RibD C-terminal domain; Region: RibD_C; cl17279 526225009405 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 526225009406 Protein of unknown function (DUF952); Region: DUF952; cl01393 526225009407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 526225009408 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 526225009409 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 526225009410 ribosome recycling factor; Reviewed; Region: frr; PRK00083 526225009411 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 526225009412 hinge region; other site 526225009413 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 526225009414 putative nucleotide binding site [chemical binding]; other site 526225009415 uridine monophosphate binding site [chemical binding]; other site 526225009416 homohexameric interface [polypeptide binding]; other site 526225009417 elongation factor Ts; Provisional; Region: tsf; PRK09377 526225009418 UBA/TS-N domain; Region: UBA; pfam00627 526225009419 Elongation factor TS; Region: EF_TS; pfam00889 526225009420 Elongation factor TS; Region: EF_TS; pfam00889 526225009421 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 526225009422 rRNA interaction site [nucleotide binding]; other site 526225009423 S8 interaction site; other site 526225009424 putative laminin-1 binding site; other site 526225009425 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526225009426 Peptidase family M23; Region: Peptidase_M23; pfam01551 526225009427 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 526225009428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225009429 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 526225009430 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225009431 DNA binding residues [nucleotide binding] 526225009432 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 526225009433 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 526225009434 active site 526225009435 DNA binding site [nucleotide binding] 526225009436 Int/Topo IB signature motif; other site 526225009437 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 526225009438 DNA protecting protein DprA; Region: dprA; TIGR00732 526225009439 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 526225009440 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 526225009441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225009442 Walker A motif; other site 526225009443 ATP binding site [chemical binding]; other site 526225009444 Walker B motif; other site 526225009445 arginine finger; other site 526225009446 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 526225009447 hypothetical protein; Reviewed; Region: PRK12497 526225009448 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 526225009449 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 526225009450 RNA/DNA hybrid binding site [nucleotide binding]; other site 526225009451 active site 526225009452 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225009453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225009454 active site 526225009455 phosphorylation site [posttranslational modification] 526225009456 intermolecular recognition site; other site 526225009457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225009458 DNA binding residues [nucleotide binding] 526225009459 dimerization interface [polypeptide binding]; other site 526225009460 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 526225009461 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 526225009462 Catalytic site [active] 526225009463 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 526225009464 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526225009465 nudix motif; other site 526225009466 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 526225009467 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 526225009468 RimM N-terminal domain; Region: RimM; pfam01782 526225009469 hypothetical protein; Provisional; Region: PRK02821 526225009470 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 526225009471 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 526225009472 prolyl-tRNA synthetase; Provisional; Region: PRK09194 526225009473 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526225009474 motif 1; other site 526225009475 dimer interface [polypeptide binding]; other site 526225009476 active site 526225009477 motif 2; other site 526225009478 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 526225009479 putative deacylase active site [active] 526225009480 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 526225009481 active site 526225009482 motif 3; other site 526225009483 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 526225009484 anticodon binding site; other site 526225009485 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 526225009486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225009487 active site 526225009488 signal recognition particle protein; Provisional; Region: PRK10867 526225009489 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 526225009490 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 526225009491 P loop; other site 526225009492 GTP binding site [chemical binding]; other site 526225009493 Signal peptide binding domain; Region: SRP_SPB; pfam02978 526225009494 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 526225009495 PII uridylyl-transferase; Provisional; Region: PRK03381 526225009496 metal binding triad; other site 526225009497 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 526225009498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526225009499 Zn2+ binding site [ion binding]; other site 526225009500 Mg2+ binding site [ion binding]; other site 526225009501 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 526225009502 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 526225009503 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 526225009504 Nitrogen regulatory protein P-II; Region: P-II; smart00938 526225009505 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 526225009506 Cobalt transport protein; Region: CbiQ; cl00463 526225009507 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 526225009508 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 526225009509 Walker A/P-loop; other site 526225009510 ATP binding site [chemical binding]; other site 526225009511 Q-loop/lid; other site 526225009512 ABC transporter signature motif; other site 526225009513 Walker B; other site 526225009514 D-loop; other site 526225009515 H-loop/switch region; other site 526225009516 PAS fold; Region: PAS_4; pfam08448 526225009517 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225009518 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 526225009519 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 526225009520 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 526225009521 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 526225009522 putative active site [active] 526225009523 putative metal binding site [ion binding]; other site 526225009524 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526225009525 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 526225009526 putative catalytic site [active] 526225009527 putative metal binding site [ion binding]; other site 526225009528 putative phosphate binding site [ion binding]; other site 526225009529 putative catalytic site [active] 526225009530 putative phosphate binding site [ion binding]; other site 526225009531 putative metal binding site [ion binding]; other site 526225009532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526225009533 Coenzyme A binding pocket [chemical binding]; other site 526225009534 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 526225009535 putative catalytic site [active] 526225009536 putative metal binding site [ion binding]; other site 526225009537 putative phosphate binding site [ion binding]; other site 526225009538 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 526225009539 AAA domain; Region: AAA_23; pfam13476 526225009540 Walker A/P-loop; other site 526225009541 ATP binding site [chemical binding]; other site 526225009542 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 526225009543 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 526225009544 ABC transporter signature motif; other site 526225009545 Walker B; other site 526225009546 D-loop; other site 526225009547 H-loop/switch region; other site 526225009548 Acylphosphatase; Region: Acylphosphatase; pfam00708 526225009549 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 526225009550 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 526225009551 DNA binding site [nucleotide binding] 526225009552 catalytic residue [active] 526225009553 H2TH interface [polypeptide binding]; other site 526225009554 putative catalytic residues [active] 526225009555 turnover-facilitating residue; other site 526225009556 intercalation triad [nucleotide binding]; other site 526225009557 8OG recognition residue [nucleotide binding]; other site 526225009558 putative reading head residues; other site 526225009559 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 526225009560 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 526225009561 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 526225009562 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 526225009563 dimerization interface [polypeptide binding]; other site 526225009564 active site 526225009565 metal binding site [ion binding]; metal-binding site 526225009566 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 526225009567 dsRNA binding site [nucleotide binding]; other site 526225009568 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 526225009569 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 526225009570 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 526225009571 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 526225009572 active site 526225009573 (T/H)XGH motif; other site 526225009574 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 526225009575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225009576 S-adenosylmethionine binding site [chemical binding]; other site 526225009577 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 526225009578 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 526225009579 generic binding surface II; other site 526225009580 ssDNA binding site; other site 526225009581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225009582 ATP binding site [chemical binding]; other site 526225009583 putative Mg++ binding site [ion binding]; other site 526225009584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225009585 nucleotide binding region [chemical binding]; other site 526225009586 ATP-binding site [chemical binding]; other site 526225009587 DAK2 domain; Region: Dak2; pfam02734 526225009588 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 526225009589 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 526225009590 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 526225009591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 526225009592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225009593 Coenzyme A binding pocket [chemical binding]; other site 526225009594 thiamine monophosphate kinase; Provisional; Region: PRK05731 526225009595 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 526225009596 ATP binding site [chemical binding]; other site 526225009597 dimerization interface [polypeptide binding]; other site 526225009598 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526225009599 AsnC family; Region: AsnC_trans_reg; pfam01037 526225009600 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 526225009601 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 526225009602 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 526225009603 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 526225009604 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 526225009605 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 526225009606 cystathionine gamma-lyase; Validated; Region: PRK07582 526225009607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526225009608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225009609 catalytic residue [active] 526225009610 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 526225009611 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 526225009612 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 526225009613 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 526225009614 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 526225009615 putative acyl-acceptor binding pocket; other site 526225009616 Guanylyl transferase CofC like; Region: CofC; cl17472 526225009617 polyphosphate kinase; Provisional; Region: PRK05443 526225009618 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 526225009619 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 526225009620 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 526225009621 putative domain interface [polypeptide binding]; other site 526225009622 putative active site [active] 526225009623 catalytic site [active] 526225009624 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 526225009625 putative domain interface [polypeptide binding]; other site 526225009626 putative active site [active] 526225009627 catalytic site [active] 526225009628 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 526225009629 active site 526225009630 Ap6A binding site [chemical binding]; other site 526225009631 nudix motif; other site 526225009632 metal binding site [ion binding]; metal-binding site 526225009633 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225009634 catalytic core [active] 526225009635 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 526225009636 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 526225009637 substrate binding site [chemical binding]; other site 526225009638 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 526225009639 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 526225009640 substrate binding site [chemical binding]; other site 526225009641 ligand binding site [chemical binding]; other site 526225009642 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 526225009643 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225009644 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225009645 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 526225009646 Moco binding site; other site 526225009647 metal coordination site [ion binding]; other site 526225009648 dimerization interface [polypeptide binding]; other site 526225009649 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 526225009650 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 526225009651 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 526225009652 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 526225009653 dimer interface [polypeptide binding]; other site 526225009654 active site 526225009655 CAAX protease self-immunity; Region: Abi; pfam02517 526225009656 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 526225009657 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 526225009658 HIGH motif; other site 526225009659 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 526225009660 active site 526225009661 KMSKS motif; other site 526225009662 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 526225009663 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 526225009664 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 526225009665 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 526225009666 active site 526225009667 Uncharacterized conserved protein [Function unknown]; Region: COG1359 526225009668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225009669 Histidine kinase; Region: HisKA_3; pfam07730 526225009670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225009671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225009672 active site 526225009673 phosphorylation site [posttranslational modification] 526225009674 intermolecular recognition site; other site 526225009675 dimerization interface [polypeptide binding]; other site 526225009676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225009677 DNA binding residues [nucleotide binding] 526225009678 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 526225009679 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 526225009680 active site 526225009681 catalytic residues [active] 526225009682 metal binding site [ion binding]; metal-binding site 526225009683 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 526225009684 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 526225009685 tartrate dehydrogenase; Region: TTC; TIGR02089 526225009686 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 526225009687 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 526225009688 ligand binding site [chemical binding]; other site 526225009689 NAD binding site [chemical binding]; other site 526225009690 dimerization interface [polypeptide binding]; other site 526225009691 catalytic site [active] 526225009692 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 526225009693 putative L-serine binding site [chemical binding]; other site 526225009694 ketol-acid reductoisomerase; Provisional; Region: PRK05479 526225009695 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 526225009696 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 526225009697 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 526225009698 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 526225009699 putative valine binding site [chemical binding]; other site 526225009700 dimer interface [polypeptide binding]; other site 526225009701 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 526225009702 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 526225009703 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 526225009704 PYR/PP interface [polypeptide binding]; other site 526225009705 dimer interface [polypeptide binding]; other site 526225009706 TPP binding site [chemical binding]; other site 526225009707 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 526225009708 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 526225009709 TPP-binding site [chemical binding]; other site 526225009710 dimer interface [polypeptide binding]; other site 526225009711 PAS domain S-box; Region: sensory_box; TIGR00229 526225009712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225009713 putative active site [active] 526225009714 heme pocket [chemical binding]; other site 526225009715 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225009716 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225009717 metal binding site [ion binding]; metal-binding site 526225009718 active site 526225009719 I-site; other site 526225009720 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225009721 PAS domain S-box; Region: sensory_box; TIGR00229 526225009722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225009723 putative active site [active] 526225009724 heme pocket [chemical binding]; other site 526225009725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225009726 metal binding site [ion binding]; metal-binding site 526225009727 active site 526225009728 I-site; other site 526225009729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225009730 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 526225009731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225009732 salt bridge; other site 526225009733 non-specific DNA binding site [nucleotide binding]; other site 526225009734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225009735 sequence-specific DNA binding site [nucleotide binding]; other site 526225009736 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 526225009737 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 526225009738 putative ligand binding site [chemical binding]; other site 526225009739 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 526225009740 putative NAD binding site [chemical binding]; other site 526225009741 catalytic site [active] 526225009742 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 526225009743 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 526225009744 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 526225009745 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 526225009746 GatB domain; Region: GatB_Yqey; smart00845 526225009747 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 526225009748 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 526225009749 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 526225009750 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 526225009751 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 526225009752 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 526225009753 nucleotide binding pocket [chemical binding]; other site 526225009754 K-X-D-G motif; other site 526225009755 catalytic site [active] 526225009756 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 526225009757 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 526225009758 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 526225009759 Dimer interface [polypeptide binding]; other site 526225009760 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 526225009761 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 526225009762 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 526225009763 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 526225009764 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 526225009765 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225009766 catalytic residue [active] 526225009767 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 526225009768 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 526225009769 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 526225009770 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 526225009771 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 526225009772 Ligand binding site [chemical binding]; other site 526225009773 Electron transfer flavoprotein domain; Region: ETF; pfam01012 526225009774 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 526225009775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225009776 substrate binding site [chemical binding]; other site 526225009777 oxyanion hole (OAH) forming residues; other site 526225009778 trimer interface [polypeptide binding]; other site 526225009779 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 526225009780 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 526225009781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225009782 Walker A/P-loop; other site 526225009783 ATP binding site [chemical binding]; other site 526225009784 Q-loop/lid; other site 526225009785 ABC transporter signature motif; other site 526225009786 Walker B; other site 526225009787 D-loop; other site 526225009788 H-loop/switch region; other site 526225009789 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 526225009790 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 526225009791 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 526225009792 active site 526225009793 catalytic site [active] 526225009794 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 526225009795 phosphopeptide binding site; other site 526225009796 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 526225009797 putative homodimer interface [polypeptide binding]; other site 526225009798 putative active site pocket [active] 526225009799 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 526225009800 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 526225009801 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 526225009802 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 526225009803 active site 526225009804 homodimer interface [polypeptide binding]; other site 526225009805 catalytic site [active] 526225009806 acceptor binding site [chemical binding]; other site 526225009807 trehalose synthase; Region: treS_nterm; TIGR02456 526225009808 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 526225009809 active site 526225009810 catalytic site [active] 526225009811 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 526225009812 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 526225009813 MARCKS family; Region: MARCKS; pfam02063 526225009814 glycogen branching enzyme; Provisional; Region: PRK05402 526225009815 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 526225009816 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 526225009817 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 526225009818 active site 526225009819 catalytic site [active] 526225009820 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 526225009821 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 526225009822 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 526225009823 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 526225009824 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 526225009825 MarR family; Region: MarR; pfam01047 526225009826 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 526225009827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225009828 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 526225009829 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 526225009830 Walker A; other site 526225009831 putative acyltransferase; Provisional; Region: PRK05790 526225009832 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 526225009833 dimer interface [polypeptide binding]; other site 526225009834 active site 526225009835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225009836 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225009837 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225009838 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 526225009839 dimer interface [polypeptide binding]; other site 526225009840 substrate binding site [chemical binding]; other site 526225009841 metal binding site [ion binding]; metal-binding site 526225009842 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225009843 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 526225009844 NAD(P) binding site [chemical binding]; other site 526225009845 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 526225009846 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 526225009847 active site 526225009848 putative catalytic site [active] 526225009849 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 526225009850 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 526225009851 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526225009852 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 526225009853 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 526225009854 hypothetical protein; Provisional; Region: PRK03298 526225009855 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 526225009856 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 526225009857 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 526225009858 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 526225009859 putative active site [active] 526225009860 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 526225009861 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 526225009862 enoyl-CoA hydratase; Validated; Region: PRK08139 526225009863 substrate binding site [chemical binding]; other site 526225009864 oxyanion hole (OAH) forming residues; other site 526225009865 trimer interface [polypeptide binding]; other site 526225009866 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 526225009867 putative oxidoreductase; Provisional; Region: PRK11579 526225009868 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225009869 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 526225009870 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 526225009871 B12 binding site [chemical binding]; other site 526225009872 cyclase homology domain; Region: CHD; cd07302 526225009873 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 526225009874 nucleotidyl binding site; other site 526225009875 metal binding site [ion binding]; metal-binding site 526225009876 dimer interface [polypeptide binding]; other site 526225009877 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 526225009878 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 526225009879 hinge; other site 526225009880 active site 526225009881 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 526225009882 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 526225009883 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 526225009884 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 526225009885 gamma subunit interface [polypeptide binding]; other site 526225009886 epsilon subunit interface [polypeptide binding]; other site 526225009887 LBP interface [polypeptide binding]; other site 526225009888 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 526225009889 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 526225009890 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 526225009891 alpha subunit interaction interface [polypeptide binding]; other site 526225009892 Walker A motif; other site 526225009893 ATP binding site [chemical binding]; other site 526225009894 Walker B motif; other site 526225009895 inhibitor binding site; inhibition site 526225009896 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 526225009897 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 526225009898 core domain interface [polypeptide binding]; other site 526225009899 delta subunit interface [polypeptide binding]; other site 526225009900 epsilon subunit interface [polypeptide binding]; other site 526225009901 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 526225009902 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 526225009903 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 526225009904 beta subunit interaction interface [polypeptide binding]; other site 526225009905 Walker A motif; other site 526225009906 ATP binding site [chemical binding]; other site 526225009907 Walker B motif; other site 526225009908 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 526225009909 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 526225009910 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 526225009911 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 526225009912 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 526225009913 ATP synthase subunit C; Region: ATP-synt_C; cl00466 526225009914 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 526225009915 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 526225009916 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 526225009917 Mg++ binding site [ion binding]; other site 526225009918 putative catalytic motif [active] 526225009919 substrate binding site [chemical binding]; other site 526225009920 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 526225009921 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 526225009922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225009923 S-adenosylmethionine binding site [chemical binding]; other site 526225009924 peptide chain release factor 1; Validated; Region: prfA; PRK00591 526225009925 This domain is found in peptide chain release factors; Region: PCRF; smart00937 526225009926 RF-1 domain; Region: RF-1; pfam00472 526225009927 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 526225009928 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 526225009929 transcription termination factor Rho; Provisional; Region: PRK12608 526225009930 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 526225009931 RNA binding site [nucleotide binding]; other site 526225009932 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 526225009933 multimer interface [polypeptide binding]; other site 526225009934 Walker A motif; other site 526225009935 ATP binding site [chemical binding]; other site 526225009936 Walker B motif; other site 526225009937 homoserine kinase; Provisional; Region: PRK01212 526225009938 threonine synthase; Reviewed; Region: PRK06721 526225009939 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 526225009940 homodimer interface [polypeptide binding]; other site 526225009941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225009942 catalytic residue [active] 526225009943 homoserine dehydrogenase; Provisional; Region: PRK06349 526225009944 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 526225009945 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 526225009946 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 526225009947 diaminopimelate decarboxylase; Region: lysA; TIGR01048 526225009948 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 526225009949 active site 526225009950 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526225009951 substrate binding site [chemical binding]; other site 526225009952 catalytic residues [active] 526225009953 dimer interface [polypeptide binding]; other site 526225009954 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 526225009955 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 526225009956 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 526225009957 active site 526225009958 HIGH motif; other site 526225009959 KMSK motif region; other site 526225009960 tRNA binding surface [nucleotide binding]; other site 526225009961 DALR anticodon binding domain; Region: DALR_1; smart00836 526225009962 anticodon binding site; other site 526225009963 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 526225009964 Domain of unknown function (DUF305); Region: DUF305; pfam03713 526225009965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225009966 NmrA-like family; Region: NmrA; pfam05368 526225009967 NAD(P) binding site [chemical binding]; other site 526225009968 active site 526225009969 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 526225009970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225009971 NAD(P) binding site [chemical binding]; other site 526225009972 active site 526225009973 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 526225009974 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 526225009975 acyl-activating enzyme (AAE) consensus motif; other site 526225009976 putative AMP binding site [chemical binding]; other site 526225009977 putative active site [active] 526225009978 putative CoA binding site [chemical binding]; other site 526225009979 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 526225009980 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 526225009981 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 526225009982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526225009983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225009984 Coenzyme A binding pocket [chemical binding]; other site 526225009985 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 526225009986 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225009987 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225009988 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 526225009989 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 526225009990 cyclase homology domain; Region: CHD; cd07302 526225009991 nucleotidyl binding site; other site 526225009992 metal binding site [ion binding]; metal-binding site 526225009993 dimer interface [polypeptide binding]; other site 526225009994 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 526225009995 Ligand Binding Site [chemical binding]; other site 526225009996 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225009997 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 526225009998 Walker A/P-loop; other site 526225009999 ATP binding site [chemical binding]; other site 526225010000 Q-loop/lid; other site 526225010001 ABC transporter signature motif; other site 526225010002 Walker B; other site 526225010003 D-loop; other site 526225010004 H-loop/switch region; other site 526225010005 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 526225010006 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 526225010007 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 526225010008 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 526225010009 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 526225010010 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 526225010011 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 526225010012 TPP-binding site [chemical binding]; other site 526225010013 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 526225010014 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 526225010015 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 526225010016 Malic enzyme, N-terminal domain; Region: malic; pfam00390 526225010017 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 526225010018 NAD(P) binding pocket [chemical binding]; other site 526225010019 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 526225010020 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 526225010021 Catalytic site [active] 526225010022 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 526225010023 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225010024 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 526225010025 dimer interface [polypeptide binding]; other site 526225010026 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 526225010027 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 526225010028 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 526225010029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225010030 Coenzyme A binding pocket [chemical binding]; other site 526225010031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225010032 UMP phosphatase; Provisional; Region: PRK10444 526225010033 active site 526225010034 motif I; other site 526225010035 motif II; other site 526225010036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225010037 motif II; other site 526225010038 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526225010039 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 526225010040 Transcription factor WhiB; Region: Whib; pfam02467 526225010041 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 526225010042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 526225010043 Histidine kinase; Region: HisKA_2; pfam07568 526225010044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225010045 Coenzyme A binding pocket [chemical binding]; other site 526225010046 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526225010047 carboxyltransferase (CT) interaction site; other site 526225010048 biotinylation site [posttranslational modification]; other site 526225010049 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526225010050 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 526225010051 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 526225010052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 526225010053 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 526225010054 DNA binding residues [nucleotide binding] 526225010055 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 526225010056 putative deacylase active site [active] 526225010057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 526225010058 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 526225010059 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 526225010060 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 526225010061 NAD(P) binding site [chemical binding]; other site 526225010062 catalytic residues [active] 526225010063 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 526225010064 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 526225010065 hinge; other site 526225010066 active site 526225010067 Predicted GTPases [General function prediction only]; Region: COG1162 526225010068 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 526225010069 GTPase/Zn-binding domain interface [polypeptide binding]; other site 526225010070 GTP/Mg2+ binding site [chemical binding]; other site 526225010071 G4 box; other site 526225010072 G5 box; other site 526225010073 G1 box; other site 526225010074 Switch I region; other site 526225010075 G2 box; other site 526225010076 G3 box; other site 526225010077 Switch II region; other site 526225010078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 526225010079 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 526225010080 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 526225010081 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 526225010082 active site 526225010083 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526225010084 nucleotide binding site [chemical binding]; other site 526225010085 XdhC Rossmann domain; Region: XdhC_C; pfam13478 526225010086 short chain dehydrogenase; Validated; Region: PRK05855 526225010087 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225010088 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225010089 active site 526225010090 catalytic tetrad [active] 526225010091 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225010092 Cytochrome P450; Region: p450; cl12078 526225010093 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225010094 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225010095 active site 526225010096 catalytic tetrad [active] 526225010097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225010098 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 526225010099 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 526225010100 dimer interface [polypeptide binding]; other site 526225010101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225010102 catalytic residue [active] 526225010103 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 526225010104 cystathionine gamma-synthase; Provisional; Region: PRK07811 526225010105 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526225010106 homodimer interface [polypeptide binding]; other site 526225010107 substrate-cofactor binding pocket; other site 526225010108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225010109 catalytic residue [active] 526225010110 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 526225010111 active site 526225010112 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 526225010113 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 526225010114 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225010115 Zn binding site [ion binding]; other site 526225010116 Predicted acetyltransferase [General function prediction only]; Region: COG2388 526225010117 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 526225010118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225010119 dimer interface [polypeptide binding]; other site 526225010120 conserved gate region; other site 526225010121 ABC-ATPase subunit interface; other site 526225010122 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 526225010123 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 526225010124 Walker A/P-loop; other site 526225010125 ATP binding site [chemical binding]; other site 526225010126 Q-loop/lid; other site 526225010127 ABC transporter signature motif; other site 526225010128 Walker B; other site 526225010129 D-loop; other site 526225010130 H-loop/switch region; other site 526225010131 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 526225010132 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 526225010133 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 526225010134 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 526225010135 active site 526225010136 iron coordination sites [ion binding]; other site 526225010137 substrate binding pocket [chemical binding]; other site 526225010138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225010139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225010140 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 526225010141 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 526225010142 hypothetical protein; Validated; Region: PRK00068 526225010143 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 526225010144 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 526225010145 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 526225010146 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 526225010147 Protein of unknown function DUF45; Region: DUF45; pfam01863 526225010148 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 526225010149 ABC1 family; Region: ABC1; pfam03109 526225010150 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 526225010151 active site 526225010152 ATP binding site [chemical binding]; other site 526225010153 Transcription factor WhiB; Region: Whib; pfam02467 526225010154 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225010155 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 526225010156 Part of AAA domain; Region: AAA_19; pfam13245 526225010157 Family description; Region: UvrD_C_2; pfam13538 526225010158 HRDC domain; Region: HRDC; pfam00570 526225010159 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 526225010160 catalytic residues [active] 526225010161 ANTAR domain; Region: ANTAR; pfam03861 526225010162 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 526225010163 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 526225010164 putative NADH binding site [chemical binding]; other site 526225010165 putative active site [active] 526225010166 nudix motif; other site 526225010167 putative metal binding site [ion binding]; other site 526225010168 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526225010169 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526225010170 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 526225010171 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 526225010172 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 526225010173 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 526225010174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 526225010175 Catalytic domain of Protein Kinases; Region: PKc; cd00180 526225010176 active site 526225010177 ATP binding site [chemical binding]; other site 526225010178 substrate binding site [chemical binding]; other site 526225010179 activation loop (A-loop); other site 526225010180 hypothetical protein; Provisional; Region: PRK08201 526225010181 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 526225010182 metal binding site [ion binding]; metal-binding site 526225010183 putative dimer interface [polypeptide binding]; other site 526225010184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225010185 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225010186 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526225010187 Part of AAA domain; Region: AAA_19; pfam13245 526225010188 Family description; Region: UvrD_C_2; pfam13538 526225010189 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 526225010190 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 526225010191 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 526225010192 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 526225010193 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497 526225010194 active site 526225010195 DNA binding site [nucleotide binding] 526225010196 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225010197 TIGR03086 family protein; Region: TIGR03086 526225010198 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 526225010199 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 526225010200 ATP binding site [chemical binding]; other site 526225010201 substrate interface [chemical binding]; other site 526225010202 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 526225010203 active site residue [active] 526225010204 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 526225010205 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 526225010206 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 526225010207 catalytic site [active] 526225010208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225010209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225010210 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 526225010211 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 526225010212 dinuclear metal binding motif [ion binding]; other site 526225010213 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 526225010214 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526225010215 ATP binding site [chemical binding]; other site 526225010216 Mg++ binding site [ion binding]; other site 526225010217 motif III; other site 526225010218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225010219 nucleotide binding region [chemical binding]; other site 526225010220 ATP-binding site [chemical binding]; other site 526225010221 PQQ-like domain; Region: PQQ_2; pfam13360 526225010222 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225010223 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225010224 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 526225010225 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 526225010226 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 526225010227 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 526225010228 active site 526225010229 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 526225010230 Bacterial PH domain; Region: DUF304; pfam03703 526225010231 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526225010232 nudix motif; other site 526225010233 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 526225010234 putative active site [active] 526225010235 putative catalytic site [active] 526225010236 Proteins of 100 residues with WXG; Region: WXG100; cl02005 526225010237 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 526225010238 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 526225010239 phosphopeptide binding site; other site 526225010240 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 526225010241 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 526225010242 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 526225010243 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 526225010244 AAA domain; Region: AAA_31; pfam13614 526225010245 Helix-turn-helix domain; Region: HTH_17; pfam12728 526225010246 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 526225010247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 526225010248 ATP binding site [chemical binding]; other site 526225010249 putative Mg++ binding site [ion binding]; other site 526225010250 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 526225010251 SEC-C motif; Region: SEC-C; pfam02810 526225010252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225010253 active site 526225010254 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 526225010255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 526225010256 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526225010257 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 526225010258 30S subunit binding site; other site 526225010259 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 526225010260 lipoprotein LpqB; Provisional; Region: PRK13613 526225010261 Sporulation and spore germination; Region: Germane; pfam10646 526225010262 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 526225010263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526225010264 dimerization interface [polypeptide binding]; other site 526225010265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225010266 dimer interface [polypeptide binding]; other site 526225010267 phosphorylation site [posttranslational modification] 526225010268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225010269 ATP binding site [chemical binding]; other site 526225010270 Mg2+ binding site [ion binding]; other site 526225010271 G-X-G motif; other site 526225010272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225010273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225010274 active site 526225010275 phosphorylation site [posttranslational modification] 526225010276 intermolecular recognition site; other site 526225010277 dimerization interface [polypeptide binding]; other site 526225010278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225010279 DNA binding site [nucleotide binding] 526225010280 Adenosylhomocysteinase; Provisional; Region: PTZ00075 526225010281 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 526225010282 homotetramer interface [polypeptide binding]; other site 526225010283 ligand binding site [chemical binding]; other site 526225010284 catalytic site [active] 526225010285 NAD binding site [chemical binding]; other site 526225010286 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 526225010287 Excalibur calcium-binding domain; Region: Excalibur; smart00894 526225010288 Methyltransferase domain; Region: Methyltransf_24; pfam13578 526225010289 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 526225010290 putative CoA binding site [chemical binding]; other site 526225010291 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 526225010292 putative trimer interface [polypeptide binding]; other site 526225010293 putative active site [active] 526225010294 putative substrate binding site [chemical binding]; other site 526225010295 putative CoA binding site [chemical binding]; other site 526225010296 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 526225010297 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 526225010298 inhibitor-cofactor binding pocket; inhibition site 526225010299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225010300 catalytic residue [active] 526225010301 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225010302 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225010303 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225010304 active site 526225010305 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 526225010306 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 526225010307 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 526225010308 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 526225010309 Bacterial phospho-glucose isomerase C-terminal region; Region: bact-PGI_C; pfam10432 526225010310 Uncharacterized conserved protein [Function unknown]; Region: COG2835 526225010311 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 526225010312 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 526225010313 active site 526225010314 substrate binding site [chemical binding]; other site 526225010315 metal binding site [ion binding]; metal-binding site 526225010316 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 526225010317 Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577 526225010318 Transcription factor WhiB; Region: Whib; pfam02467 526225010319 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 526225010320 dimer interface [polypeptide binding]; other site 526225010321 phosphate binding site [ion binding]; other site 526225010322 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 526225010323 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 526225010324 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 526225010325 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 526225010326 substrate binding site; other site 526225010327 tetramer interface; other site 526225010328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225010329 active site 526225010330 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 526225010331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225010332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225010333 NAD(P) binding site [chemical binding]; other site 526225010334 active site 526225010335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225010336 FAD dependent oxidoreductase; Region: DAO; pfam01266 526225010337 hydroxyglutarate oxidase; Provisional; Region: PRK11728 526225010338 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 526225010339 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 526225010340 helix-hairpin-helix signature motif; other site 526225010341 active site 526225010342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225010343 NAD(P) binding site [chemical binding]; other site 526225010344 active site 526225010345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225010346 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 526225010347 active site 526225010348 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225010349 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 526225010350 Probable Catalytic site; other site 526225010351 metal-binding site 526225010352 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 526225010353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225010354 UDP-galactopyranose mutase; Region: GLF; pfam03275 526225010355 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526225010356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225010357 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526225010358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225010359 active site 526225010360 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 526225010361 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 526225010362 Walker A/P-loop; other site 526225010363 ATP binding site [chemical binding]; other site 526225010364 Q-loop/lid; other site 526225010365 ABC transporter signature motif; other site 526225010366 Walker B; other site 526225010367 D-loop; other site 526225010368 H-loop/switch region; other site 526225010369 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 526225010370 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 526225010371 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 526225010372 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225010373 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225010374 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 526225010375 LGFP repeat; Region: LGFP; pfam08310 526225010376 LGFP repeat; Region: LGFP; pfam08310 526225010377 LGFP repeat; Region: LGFP; pfam08310 526225010378 LGFP repeat; Region: LGFP; pfam08310 526225010379 LGFP repeat; Region: LGFP; pfam08310 526225010380 LGFP repeat; Region: LGFP; pfam08310 526225010381 LGFP repeat; Region: LGFP; pfam08310 526225010382 LGFP repeat; Region: LGFP; pfam08310 526225010383 LGFP repeat; Region: LGFP; pfam08310 526225010384 LGFP repeat; Region: LGFP; pfam08310 526225010385 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 526225010386 amidase catalytic site [active] 526225010387 Zn binding residues [ion binding]; other site 526225010388 substrate binding site [chemical binding]; other site 526225010389 LGFP repeat; Region: LGFP; pfam08310 526225010390 LGFP repeat; Region: LGFP; pfam08310 526225010391 LGFP repeat; Region: LGFP; pfam08310 526225010392 LGFP repeat; Region: LGFP; pfam08310 526225010393 LGFP repeat; Region: LGFP; pfam08310 526225010394 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 526225010395 LGFP repeat; Region: LGFP; pfam08310 526225010396 LGFP repeat; Region: LGFP; pfam08310 526225010397 LGFP repeat; Region: LGFP; pfam08310 526225010398 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 526225010399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225010400 NAD(P) binding site [chemical binding]; other site 526225010401 active site 526225010402 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 526225010403 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 526225010404 NAD binding site [chemical binding]; other site 526225010405 substrate binding site [chemical binding]; other site 526225010406 homodimer interface [polypeptide binding]; other site 526225010407 active site 526225010408 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 526225010409 ligand binding site; other site 526225010410 tetramer interface; other site 526225010411 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 526225010412 active site 526225010413 homodimer interface [polypeptide binding]; other site 526225010414 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 526225010415 NeuB family; Region: NeuB; pfam03102 526225010416 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 526225010417 NeuB binding interface [polypeptide binding]; other site 526225010418 putative substrate binding site [chemical binding]; other site 526225010419 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 526225010420 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 526225010421 TIGR03089 family protein; Region: TIGR03089 526225010422 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 526225010423 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 526225010424 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 526225010425 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 526225010426 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 526225010427 Predicted membrane protein [Function unknown]; Region: COG2323 526225010428 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 526225010429 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 526225010430 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 526225010431 DNA binding residues [nucleotide binding] 526225010432 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 526225010433 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 526225010434 Sulfate transporter family; Region: Sulfate_transp; pfam00916 526225010435 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 526225010436 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225010437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225010438 active site 526225010439 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 526225010440 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 526225010441 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225010442 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 526225010443 active site 526225010444 catalytic triad [active] 526225010445 oxyanion hole [active] 526225010446 Acyltransferase family; Region: Acyl_transf_3; pfam01757 526225010447 GtrA-like protein; Region: GtrA; pfam04138 526225010448 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 526225010449 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 526225010450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225010451 Walker A/P-loop; other site 526225010452 ATP binding site [chemical binding]; other site 526225010453 Q-loop/lid; other site 526225010454 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 526225010455 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 526225010456 ABC transporter signature motif; other site 526225010457 Walker B; other site 526225010458 D-loop; other site 526225010459 H-loop/switch region; other site 526225010460 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 526225010461 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526225010462 active site 526225010463 metal binding site [ion binding]; metal-binding site 526225010464 DNA binding site [nucleotide binding] 526225010465 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 526225010466 Bacterial PH domain; Region: DUF304; pfam03703 526225010467 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 526225010468 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 526225010469 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 526225010470 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 526225010471 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 526225010472 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 526225010473 Maf-like protein; Region: Maf; pfam02545 526225010474 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 526225010475 active site 526225010476 dimer interface [polypeptide binding]; other site 526225010477 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 526225010478 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 526225010479 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 526225010480 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 526225010481 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 526225010482 carboxyltransferase (CT) interaction site; other site 526225010483 biotinylation site [posttranslational modification]; other site 526225010484 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 526225010485 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 526225010486 LGFP repeat; Region: LGFP; pfam08310 526225010487 LGFP repeat; Region: LGFP; pfam08310 526225010488 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 526225010489 LGFP repeat; Region: LGFP; pfam08310 526225010490 LGFP repeat; Region: LGFP; pfam08310 526225010491 LGFP repeat; Region: LGFP; pfam08310 526225010492 LGFP repeat; Region: LGFP; pfam08310 526225010493 LGFP repeat; Region: LGFP; pfam08310 526225010494 LGFP repeat; Region: LGFP; pfam08310 526225010495 LGFP repeat; Region: LGFP; pfam08310 526225010496 LGFP repeat; Region: LGFP; pfam08310 526225010497 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 526225010498 active site 526225010499 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 526225010500 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 526225010501 NAD binding site [chemical binding]; other site 526225010502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225010503 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 526225010504 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 526225010505 putative active site pocket [active] 526225010506 dimerization interface [polypeptide binding]; other site 526225010507 putative catalytic residue [active] 526225010508 membrane ATPase/protein kinase; Provisional; Region: PRK09435 526225010509 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 526225010510 Walker A; other site 526225010511 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 526225010512 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 526225010513 active site 526225010514 substrate binding site [chemical binding]; other site 526225010515 coenzyme B12 binding site [chemical binding]; other site 526225010516 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 526225010517 B12 binding site [chemical binding]; other site 526225010518 cobalt ligand [ion binding]; other site 526225010519 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 526225010520 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 526225010521 heterodimer interface [polypeptide binding]; other site 526225010522 substrate interaction site [chemical binding]; other site 526225010523 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 526225010524 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 526225010525 metal binding site [ion binding]; metal-binding site 526225010526 putative dimer interface [polypeptide binding]; other site 526225010527 carboxylate-amine ligase; Provisional; Region: PRK13517 526225010528 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 526225010529 purine nucleoside phosphorylase; Provisional; Region: PRK08202 526225010530 extended (e) SDRs; Region: SDR_e; cd08946 526225010531 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225010532 NAD(P) binding site [chemical binding]; other site 526225010533 active site 526225010534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225010535 substrate binding site [chemical binding]; other site 526225010536 active site 526225010537 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 526225010538 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 526225010539 active site 526225010540 substrate binding site [chemical binding]; other site 526225010541 metal binding site [ion binding]; metal-binding site 526225010542 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 526225010543 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 526225010544 intersubunit interface [polypeptide binding]; other site 526225010545 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 526225010546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225010547 motif II; other site 526225010548 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 526225010549 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 526225010550 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526225010551 active site 526225010552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225010553 Coenzyme A binding pocket [chemical binding]; other site 526225010554 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 526225010555 intersubunit interface [polypeptide binding]; other site 526225010556 active site 526225010557 catalytic residue [active] 526225010558 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 526225010559 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 526225010560 NAD(P) binding site [chemical binding]; other site 526225010561 catalytic residues [active] 526225010562 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 526225010563 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 526225010564 NAD(P) binding site [chemical binding]; other site 526225010565 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 526225010566 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526225010567 ATP binding site [chemical binding]; other site 526225010568 Mg++ binding site [ion binding]; other site 526225010569 motif III; other site 526225010570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225010571 nucleotide binding region [chemical binding]; other site 526225010572 ATP-binding site [chemical binding]; other site 526225010573 adenosine deaminase; Provisional; Region: PRK09358 526225010574 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 526225010575 active site 526225010576 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 526225010577 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526225010578 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225010579 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526225010580 Walker A/P-loop; other site 526225010581 ATP binding site [chemical binding]; other site 526225010582 Q-loop/lid; other site 526225010583 ABC transporter signature motif; other site 526225010584 Walker B; other site 526225010585 D-loop; other site 526225010586 H-loop/switch region; other site 526225010587 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 526225010588 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 526225010589 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 526225010590 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 526225010591 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 526225010592 active site 526225010593 catalytic motif [active] 526225010594 Zn binding site [ion binding]; other site 526225010595 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 526225010596 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225010597 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526225010598 TM-ABC transporter signature motif; other site 526225010599 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 526225010600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 526225010601 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 526225010602 TM-ABC transporter signature motif; other site 526225010603 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 526225010604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 526225010605 Walker A/P-loop; other site 526225010606 ATP binding site [chemical binding]; other site 526225010607 Q-loop/lid; other site 526225010608 ABC transporter signature motif; other site 526225010609 Walker B; other site 526225010610 D-loop; other site 526225010611 H-loop/switch region; other site 526225010612 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 526225010613 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 526225010614 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 526225010615 ligand binding site [chemical binding]; other site 526225010616 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 526225010617 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 526225010618 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 526225010619 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 526225010620 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 526225010621 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 526225010622 active site 526225010623 HIGH motif; other site 526225010624 dimer interface [polypeptide binding]; other site 526225010625 KMSKS motif; other site 526225010626 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 526225010627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526225010628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225010629 homodimer interface [polypeptide binding]; other site 526225010630 catalytic residue [active] 526225010631 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 526225010632 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 526225010633 NAD binding site [chemical binding]; other site 526225010634 homodimer interface [polypeptide binding]; other site 526225010635 active site 526225010636 substrate binding site [chemical binding]; other site 526225010637 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 526225010638 Domain of unknown function DUF21; Region: DUF21; pfam01595 526225010639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 526225010640 Transporter associated domain; Region: CorC_HlyC; smart01091 526225010641 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 526225010642 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 526225010643 isocitrate dehydrogenase; Validated; Region: PRK08299 526225010644 malate dehydrogenase; Reviewed; Region: PRK06223 526225010645 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 526225010646 NAD(P) binding site [chemical binding]; other site 526225010647 dimer interface [polypeptide binding]; other site 526225010648 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526225010649 substrate binding site [chemical binding]; other site 526225010650 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 526225010651 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 526225010652 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882 526225010653 NAD(P) binding pocket [chemical binding]; other site 526225010654 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 526225010655 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 526225010656 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 526225010657 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 526225010658 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 526225010659 purine monophosphate binding site [chemical binding]; other site 526225010660 dimer interface [polypeptide binding]; other site 526225010661 putative catalytic residues [active] 526225010662 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 526225010663 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 526225010664 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 526225010665 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 526225010666 active site 526225010667 substrate binding site [chemical binding]; other site 526225010668 cosubstrate binding site; other site 526225010669 catalytic site [active] 526225010670 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 526225010671 CoA binding domain; Region: CoA_binding; smart00881 526225010672 CoA-ligase; Region: Ligase_CoA; pfam00549 526225010673 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 526225010674 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 526225010675 CoA-ligase; Region: Ligase_CoA; pfam00549 526225010676 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 526225010677 B12 binding site [chemical binding]; other site 526225010678 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225010679 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 526225010680 PGAP1-like protein; Region: PGAP1; pfam07819 526225010681 nucleophilic elbow; other site 526225010682 catalytic triad; other site 526225010683 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526225010684 Peptidase family M23; Region: Peptidase_M23; pfam01551 526225010685 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 526225010686 Part of AAA domain; Region: AAA_19; pfam13245 526225010687 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 526225010688 Family description; Region: UvrD_C_2; pfam13538 526225010689 Chorismate mutase type II; Region: CM_2; cl00693 526225010690 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 526225010691 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 526225010692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225010693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225010694 active site 526225010695 phosphorylation site [posttranslational modification] 526225010696 intermolecular recognition site; other site 526225010697 dimerization interface [polypeptide binding]; other site 526225010698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225010699 DNA binding residues [nucleotide binding] 526225010700 dimerization interface [polypeptide binding]; other site 526225010701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225010702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225010703 ATP binding site [chemical binding]; other site 526225010704 Mg2+ binding site [ion binding]; other site 526225010705 G-X-G motif; other site 526225010706 PspC domain; Region: PspC; pfam04024 526225010707 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 526225010708 glutamate dehydrogenase; Provisional; Region: PRK09414 526225010709 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 526225010710 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 526225010711 NAD(P) binding site [chemical binding]; other site 526225010712 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 526225010713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225010714 Coenzyme A binding pocket [chemical binding]; other site 526225010715 GMP synthase; Reviewed; Region: guaA; PRK00074 526225010716 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 526225010717 AMP/PPi binding site [chemical binding]; other site 526225010718 candidate oxyanion hole; other site 526225010719 catalytic triad [active] 526225010720 potential glutamine specificity residues [chemical binding]; other site 526225010721 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 526225010722 ATP Binding subdomain [chemical binding]; other site 526225010723 Ligand Binding sites [chemical binding]; other site 526225010724 Dimerization subdomain; other site 526225010725 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 526225010726 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225010727 phosphate binding site [ion binding]; other site 526225010728 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 526225010729 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225010730 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 526225010731 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 526225010732 active site 526225010733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225010734 active site 526225010735 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225010736 phosphorylation site [posttranslational modification] 526225010737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225010738 DNA binding residues [nucleotide binding] 526225010739 dimerization interface [polypeptide binding]; other site 526225010740 Transcription factor WhiB; Region: Whib; pfam02467 526225010741 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 526225010742 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 526225010743 ring oligomerisation interface [polypeptide binding]; other site 526225010744 ATP/Mg binding site [chemical binding]; other site 526225010745 stacking interactions; other site 526225010746 hinge regions; other site 526225010747 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 526225010748 oligomerisation interface [polypeptide binding]; other site 526225010749 mobile loop; other site 526225010750 roof hairpin; other site 526225010751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225010752 S-adenosylmethionine binding site [chemical binding]; other site 526225010753 UGMP family protein; Validated; Region: PRK09604 526225010754 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 526225010755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225010756 Coenzyme A binding pocket [chemical binding]; other site 526225010757 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 526225010758 Glycoprotease family; Region: Peptidase_M22; pfam00814 526225010759 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 526225010760 nudix motif; other site 526225010761 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 526225010762 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 526225010763 Fe-S cluster binding site [ion binding]; other site 526225010764 active site 526225010765 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225010766 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225010767 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 526225010768 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 526225010769 alanine racemase; Reviewed; Region: alr; PRK00053 526225010770 active site 526225010771 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 526225010772 dimer interface [polypeptide binding]; other site 526225010773 substrate binding site [chemical binding]; other site 526225010774 catalytic residues [active] 526225010775 Uncharacterized conserved protein [Function unknown]; Region: COG0062 526225010776 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 526225010777 putative substrate binding site [chemical binding]; other site 526225010778 putative ATP binding site [chemical binding]; other site 526225010779 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 526225010780 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 526225010781 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 526225010782 glutaminase active site [active] 526225010783 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 526225010784 dimer interface [polypeptide binding]; other site 526225010785 active site 526225010786 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 526225010787 dimer interface [polypeptide binding]; other site 526225010788 active site 526225010789 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 526225010790 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 526225010791 active site 526225010792 substrate binding site [chemical binding]; other site 526225010793 metal binding site [ion binding]; metal-binding site 526225010794 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 526225010795 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 526225010796 23S rRNA interface [nucleotide binding]; other site 526225010797 L3 interface [polypeptide binding]; other site 526225010798 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 526225010799 active site clefts [active] 526225010800 zinc binding site [ion binding]; other site 526225010801 dimer interface [polypeptide binding]; other site 526225010802 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 526225010803 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 526225010804 dimer interface [polypeptide binding]; other site 526225010805 putative functional site; other site 526225010806 putative MPT binding site; other site 526225010807 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 526225010808 trimer interface [polypeptide binding]; other site 526225010809 dimer interface [polypeptide binding]; other site 526225010810 putative active site [active] 526225010811 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 526225010812 MPT binding site; other site 526225010813 trimer interface [polypeptide binding]; other site 526225010814 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 526225010815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225010816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225010817 NADH(P)-binding; Region: NAD_binding_10; pfam13460 526225010818 NAD(P) binding site [chemical binding]; other site 526225010819 active site 526225010820 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 526225010821 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 526225010822 dimerization interface 3.5A [polypeptide binding]; other site 526225010823 active site 526225010824 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 526225010825 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 526225010826 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 526225010827 alphaNTD homodimer interface [polypeptide binding]; other site 526225010828 alphaNTD - beta interaction site [polypeptide binding]; other site 526225010829 alphaNTD - beta' interaction site [polypeptide binding]; other site 526225010830 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 526225010831 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 526225010832 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 526225010833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 526225010834 RNA binding surface [nucleotide binding]; other site 526225010835 30S ribosomal protein S11; Validated; Region: PRK05309 526225010836 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 526225010837 30S ribosomal protein S13; Region: bact_S13; TIGR03631 526225010838 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 526225010839 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 526225010840 rRNA binding site [nucleotide binding]; other site 526225010841 predicted 30S ribosome binding site; other site 526225010842 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 526225010843 active site 526225010844 adenylate kinase; Reviewed; Region: adk; PRK00279 526225010845 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 526225010846 AMP-binding site [chemical binding]; other site 526225010847 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 526225010848 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 526225010849 SecY translocase; Region: SecY; pfam00344 526225010850 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 526225010851 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 526225010852 23S rRNA binding site [nucleotide binding]; other site 526225010853 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 526225010854 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 526225010855 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 526225010856 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 526225010857 5S rRNA interface [nucleotide binding]; other site 526225010858 23S rRNA interface [nucleotide binding]; other site 526225010859 L5 interface [polypeptide binding]; other site 526225010860 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 526225010861 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 526225010862 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 526225010863 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 526225010864 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 526225010865 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 526225010866 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 526225010867 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 526225010868 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 526225010869 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 526225010870 RNA binding site [nucleotide binding]; other site 526225010871 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 526225010872 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 526225010873 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 526225010874 putative translocon interaction site; other site 526225010875 23S rRNA interface [nucleotide binding]; other site 526225010876 signal recognition particle (SRP54) interaction site; other site 526225010877 L23 interface [polypeptide binding]; other site 526225010878 trigger factor interaction site; other site 526225010879 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 526225010880 23S rRNA interface [nucleotide binding]; other site 526225010881 5S rRNA interface [nucleotide binding]; other site 526225010882 putative antibiotic binding site [chemical binding]; other site 526225010883 L25 interface [polypeptide binding]; other site 526225010884 L27 interface [polypeptide binding]; other site 526225010885 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 526225010886 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 526225010887 G-X-X-G motif; other site 526225010888 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 526225010889 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 526225010890 putative translocon binding site; other site 526225010891 protein-rRNA interface [nucleotide binding]; other site 526225010892 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 526225010893 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 526225010894 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 526225010895 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 526225010896 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 526225010897 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 526225010898 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 526225010899 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 526225010900 elongation factor Tu; Reviewed; Region: PRK00049 526225010901 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 526225010902 G1 box; other site 526225010903 GEF interaction site [polypeptide binding]; other site 526225010904 GTP/Mg2+ binding site [chemical binding]; other site 526225010905 Switch I region; other site 526225010906 G2 box; other site 526225010907 G3 box; other site 526225010908 Switch II region; other site 526225010909 G4 box; other site 526225010910 G5 box; other site 526225010911 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 526225010912 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 526225010913 Antibiotic Binding Site [chemical binding]; other site 526225010914 elongation factor G; Reviewed; Region: PRK00007 526225010915 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 526225010916 G1 box; other site 526225010917 putative GEF interaction site [polypeptide binding]; other site 526225010918 GTP/Mg2+ binding site [chemical binding]; other site 526225010919 Switch I region; other site 526225010920 G2 box; other site 526225010921 G3 box; other site 526225010922 Switch II region; other site 526225010923 G4 box; other site 526225010924 G5 box; other site 526225010925 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 526225010926 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 526225010927 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 526225010928 30S ribosomal protein S7; Validated; Region: PRK05302 526225010929 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 526225010930 S17 interaction site [polypeptide binding]; other site 526225010931 S8 interaction site; other site 526225010932 16S rRNA interaction site [nucleotide binding]; other site 526225010933 streptomycin interaction site [chemical binding]; other site 526225010934 23S rRNA interaction site [nucleotide binding]; other site 526225010935 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 526225010936 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 526225010937 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 526225010938 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 526225010939 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 526225010940 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 526225010941 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 526225010942 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 526225010943 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 526225010944 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 526225010945 G-loop; other site 526225010946 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 526225010947 DNA binding site [nucleotide binding] 526225010948 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 526225010949 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 526225010950 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 526225010951 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 526225010952 RPB10 interaction site [polypeptide binding]; other site 526225010953 RPB1 interaction site [polypeptide binding]; other site 526225010954 RPB11 interaction site [polypeptide binding]; other site 526225010955 RPB3 interaction site [polypeptide binding]; other site 526225010956 RPB12 interaction site [polypeptide binding]; other site 526225010957 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 526225010958 core dimer interface [polypeptide binding]; other site 526225010959 peripheral dimer interface [polypeptide binding]; other site 526225010960 L10 interface [polypeptide binding]; other site 526225010961 L11 interface [polypeptide binding]; other site 526225010962 putative EF-Tu interaction site [polypeptide binding]; other site 526225010963 putative EF-G interaction site [polypeptide binding]; other site 526225010964 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 526225010965 23S rRNA interface [nucleotide binding]; other site 526225010966 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 526225010967 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 526225010968 mRNA/rRNA interface [nucleotide binding]; other site 526225010969 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 526225010970 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 526225010971 23S rRNA interface [nucleotide binding]; other site 526225010972 L7/L12 interface [polypeptide binding]; other site 526225010973 putative thiostrepton binding site; other site 526225010974 L25 interface [polypeptide binding]; other site 526225010975 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 526225010976 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 526225010977 putative homodimer interface [polypeptide binding]; other site 526225010978 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 526225010979 heterodimer interface [polypeptide binding]; other site 526225010980 homodimer interface [polypeptide binding]; other site 526225010981 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 526225010982 aspartate aminotransferase; Provisional; Region: PRK05764 526225010983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526225010984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225010985 homodimer interface [polypeptide binding]; other site 526225010986 catalytic residue [active] 526225010987 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 526225010988 Zn binding site [ion binding]; other site 526225010989 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 526225010990 active site 526225010991 catalytic site [active] 526225010992 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 526225010993 active site 526225010994 catalytic site [active] 526225010995 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 526225010996 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225010997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225010998 metal binding site [ion binding]; metal-binding site 526225010999 active site 526225011000 I-site; other site 526225011001 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225011002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 526225011003 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 526225011004 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 526225011005 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225011006 DNA binding residues [nucleotide binding] 526225011007 dimer interface [polypeptide binding]; other site 526225011008 heat shock protein HtpX; Provisional; Region: PRK03072 526225011009 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 526225011010 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 526225011011 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 526225011012 dimer interface [polypeptide binding]; other site 526225011013 PYR/PP interface [polypeptide binding]; other site 526225011014 TPP binding site [chemical binding]; other site 526225011015 substrate binding site [chemical binding]; other site 526225011016 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 526225011017 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 526225011018 TPP-binding site [chemical binding]; other site 526225011019 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 526225011020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 526225011021 DNA-binding site [nucleotide binding]; DNA binding site 526225011022 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526225011023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225011024 catalytic residue [active] 526225011025 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 526225011026 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 526225011027 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 526225011028 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 526225011029 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 526225011030 substrate binding pocket [chemical binding]; other site 526225011031 chain length determination region; other site 526225011032 substrate-Mg2+ binding site; other site 526225011033 catalytic residues [active] 526225011034 aspartate-rich region 1; other site 526225011035 active site lid residues [active] 526225011036 aspartate-rich region 2; other site 526225011037 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 526225011038 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225011039 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 526225011040 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225011041 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 526225011042 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 526225011043 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 526225011044 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 526225011045 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 526225011046 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 526225011047 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 526225011048 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 526225011049 4Fe-4S binding domain; Region: Fer4; pfam00037 526225011050 4Fe-4S binding domain; Region: Fer4; pfam00037 526225011051 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 526225011052 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 526225011053 NADH dehydrogenase subunit G; Validated; Region: PRK07860 526225011054 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225011055 catalytic loop [active] 526225011056 iron binding site [ion binding]; other site 526225011057 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 526225011058 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 526225011059 molybdopterin cofactor binding site; other site 526225011060 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 526225011061 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 526225011062 SLBB domain; Region: SLBB; pfam10531 526225011063 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 526225011064 NADH dehydrogenase subunit E; Validated; Region: PRK07539 526225011065 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 526225011066 putative dimer interface [polypeptide binding]; other site 526225011067 [2Fe-2S] cluster binding site [ion binding]; other site 526225011068 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 526225011069 NADH dehydrogenase subunit D; Validated; Region: PRK06075 526225011070 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 526225011071 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 526225011072 NADH dehydrogenase subunit B; Validated; Region: PRK06411 526225011073 NADH dehydrogenase subunit A; Validated; Region: PRK07928 526225011074 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 526225011075 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225011076 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 526225011077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225011078 S-adenosylmethionine binding site [chemical binding]; other site 526225011079 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 526225011080 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 526225011081 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 526225011082 dimer interface [polypeptide binding]; other site 526225011083 tetramer interface [polypeptide binding]; other site 526225011084 PYR/PP interface [polypeptide binding]; other site 526225011085 TPP binding site [chemical binding]; other site 526225011086 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 526225011087 TPP-binding site [chemical binding]; other site 526225011088 O-succinylbenzoate synthase; Provisional; Region: PRK02901 526225011089 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 526225011090 active site 526225011091 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225011092 active site 526225011093 CoA binding site [chemical binding]; other site 526225011094 AMP binding site [chemical binding]; other site 526225011095 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 526225011096 UbiA prenyltransferase family; Region: UbiA; pfam01040 526225011097 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526225011098 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225011099 putative DNA binding site [nucleotide binding]; other site 526225011100 putative Zn2+ binding site [ion binding]; other site 526225011101 AsnC family; Region: AsnC_trans_reg; pfam01037 526225011102 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 526225011103 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 526225011104 ResB-like family; Region: ResB; pfam05140 526225011105 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 526225011106 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 526225011107 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 526225011108 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 526225011109 catalytic residues [active] 526225011110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225011111 catalytic core [active] 526225011112 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 526225011113 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 526225011114 inhibitor-cofactor binding pocket; inhibition site 526225011115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225011116 catalytic residue [active] 526225011117 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 526225011118 dimer interface [polypeptide binding]; other site 526225011119 active site 526225011120 Schiff base residues; other site 526225011121 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 526225011122 active site 526225011123 SAM binding site [chemical binding]; other site 526225011124 homodimer interface [polypeptide binding]; other site 526225011125 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 526225011126 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 526225011127 active site 526225011128 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 526225011129 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 526225011130 domain interfaces; other site 526225011131 active site 526225011132 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 526225011133 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 526225011134 tRNA; other site 526225011135 putative tRNA binding site [nucleotide binding]; other site 526225011136 putative NADP binding site [chemical binding]; other site 526225011137 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 526225011138 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 526225011139 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 526225011140 CoA binding domain; Region: CoA_binding; pfam02629 526225011141 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 526225011142 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 526225011143 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 526225011144 acyl-activating enzyme (AAE) consensus motif; other site 526225011145 AMP binding site [chemical binding]; other site 526225011146 active site 526225011147 CoA binding site [chemical binding]; other site 526225011148 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 526225011149 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 526225011150 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 526225011151 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 526225011152 putative acyl-acceptor binding pocket; other site 526225011153 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 526225011154 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225011155 putative NAD(P) binding site [chemical binding]; other site 526225011156 active site 526225011157 putative substrate binding site [chemical binding]; other site 526225011158 DNA binding domain, excisionase family; Region: excise; TIGR01764 526225011159 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 526225011160 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 526225011161 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 526225011162 intracellular protease, PfpI family; Region: PfpI; TIGR01382 526225011163 proposed catalytic triad [active] 526225011164 conserved cys residue [active] 526225011165 exopolyphosphatase; Region: exo_poly_only; TIGR03706 526225011166 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 526225011167 H+ Antiporter protein; Region: 2A0121; TIGR00900 526225011168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225011169 putative substrate translocation pore; other site 526225011170 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 526225011171 active site 526225011172 Methyltransferase domain; Region: Methyltransf_23; pfam13489 526225011173 Methyltransferase domain; Region: Methyltransf_11; pfam08241 526225011174 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 526225011175 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 526225011176 conserved cys residue [active] 526225011177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225011178 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 526225011179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225011180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225011181 active site 526225011182 phosphorylation site [posttranslational modification] 526225011183 intermolecular recognition site; other site 526225011184 dimerization interface [polypeptide binding]; other site 526225011185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225011186 DNA binding site [nucleotide binding] 526225011187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225011188 dimer interface [polypeptide binding]; other site 526225011189 phosphorylation site [posttranslational modification] 526225011190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225011191 ATP binding site [chemical binding]; other site 526225011192 G-X-G motif; other site 526225011193 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 526225011194 PhoU domain; Region: PhoU; pfam01895 526225011195 PhoU domain; Region: PhoU; pfam01895 526225011196 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 526225011197 catalytic core [active] 526225011198 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 526225011199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225011200 putative substrate translocation pore; other site 526225011201 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 526225011202 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 526225011203 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 526225011204 putative ADP-binding pocket [chemical binding]; other site 526225011205 malonic semialdehyde reductase; Provisional; Region: PRK10538 526225011206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225011207 NAD(P) binding site [chemical binding]; other site 526225011208 active site 526225011209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 526225011210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225011211 Coenzyme A binding pocket [chemical binding]; other site 526225011212 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 526225011213 FAD binding domain; Region: FAD_binding_4; pfam01565 526225011214 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 526225011215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 526225011216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225011217 Protein of unknown function (DUF1059); Region: DUF1059; pfam06348 526225011218 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225011219 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225011220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 526225011221 RNase III inhibitor; Provisional; Region: PRK00431 526225011222 ADP-ribose binding site [chemical binding]; other site 526225011223 PspC domain; Region: PspC; pfam04024 526225011224 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 526225011225 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225011226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225011227 non-specific DNA binding site [nucleotide binding]; other site 526225011228 salt bridge; other site 526225011229 sequence-specific DNA binding site [nucleotide binding]; other site 526225011230 L-asparaginase II; Region: Asparaginase_II; pfam06089 526225011231 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 526225011232 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 526225011233 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 526225011234 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 526225011235 metal binding site 2 [ion binding]; metal-binding site 526225011236 putative DNA binding helix; other site 526225011237 metal binding site 1 [ion binding]; metal-binding site 526225011238 dimer interface [polypeptide binding]; other site 526225011239 structural Zn2+ binding site [ion binding]; other site 526225011240 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 526225011241 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 526225011242 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 526225011243 butyrate kinase; Provisional; Region: PRK03011 526225011244 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 526225011245 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 526225011246 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 526225011247 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 526225011248 heme-binding site [chemical binding]; other site 526225011249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225011250 NAD(P) binding site [chemical binding]; other site 526225011251 active site 526225011252 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 526225011253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225011254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225011255 Predicted transcriptional regulators [Transcription]; Region: COG1695 526225011256 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 526225011257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225011258 Walker A/P-loop; other site 526225011259 ATP binding site [chemical binding]; other site 526225011260 Q-loop/lid; other site 526225011261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225011262 PAS domain; Region: PAS_9; pfam13426 526225011263 putative active site [active] 526225011264 heme pocket [chemical binding]; other site 526225011265 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225011266 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 526225011267 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 526225011268 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 526225011269 active site residue [active] 526225011270 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 526225011271 active site residue [active] 526225011272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526225011273 catalytic residues [active] 526225011274 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 526225011275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225011276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225011277 DNA binding site [nucleotide binding] 526225011278 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 526225011279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 526225011280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225011281 Coenzyme A binding pocket [chemical binding]; other site 526225011282 PBP superfamily domain; Region: PBP_like_2; cl17296 526225011283 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 526225011284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225011285 conserved gate region; other site 526225011286 ABC-ATPase subunit interface; other site 526225011287 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 526225011288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225011289 dimer interface [polypeptide binding]; other site 526225011290 conserved gate region; other site 526225011291 putative PBP binding loops; other site 526225011292 ABC-ATPase subunit interface; other site 526225011293 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 526225011294 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 526225011295 Walker A/P-loop; other site 526225011296 ATP binding site [chemical binding]; other site 526225011297 Q-loop/lid; other site 526225011298 ABC transporter signature motif; other site 526225011299 Walker B; other site 526225011300 D-loop; other site 526225011301 H-loop/switch region; other site 526225011302 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 526225011303 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 526225011304 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 526225011305 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 526225011306 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 526225011307 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 526225011308 FAD binding pocket [chemical binding]; other site 526225011309 FAD binding motif [chemical binding]; other site 526225011310 phosphate binding motif [ion binding]; other site 526225011311 NAD binding pocket [chemical binding]; other site 526225011312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225011313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225011314 active site 526225011315 phosphorylation site [posttranslational modification] 526225011316 intermolecular recognition site; other site 526225011317 dimerization interface [polypeptide binding]; other site 526225011318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225011319 DNA binding site [nucleotide binding] 526225011320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225011321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526225011322 dimerization interface [polypeptide binding]; other site 526225011323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225011324 dimer interface [polypeptide binding]; other site 526225011325 phosphorylation site [posttranslational modification] 526225011326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225011327 ATP binding site [chemical binding]; other site 526225011328 Mg2+ binding site [ion binding]; other site 526225011329 G-X-G motif; other site 526225011330 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 526225011331 CoenzymeA binding site [chemical binding]; other site 526225011332 subunit interaction site [polypeptide binding]; other site 526225011333 PHB binding site; other site 526225011334 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 526225011335 active site 526225011336 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 526225011337 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 526225011338 Active Sites [active] 526225011339 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 526225011340 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 526225011341 CysD dimerization site [polypeptide binding]; other site 526225011342 G1 box; other site 526225011343 putative GEF interaction site [polypeptide binding]; other site 526225011344 GTP/Mg2+ binding site [chemical binding]; other site 526225011345 Switch I region; other site 526225011346 G2 box; other site 526225011347 G3 box; other site 526225011348 Switch II region; other site 526225011349 G4 box; other site 526225011350 G5 box; other site 526225011351 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 526225011352 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 526225011353 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 526225011354 FAD binding domain; Region: FAD_binding_4; pfam01565 526225011355 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 526225011356 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 526225011357 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225011358 catalytic loop [active] 526225011359 iron binding site [ion binding]; other site 526225011360 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 526225011361 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 526225011362 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 526225011363 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526225011364 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 526225011365 Cytochrome P450; Region: p450; cl12078 526225011366 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225011367 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 526225011368 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 526225011369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225011370 ATP binding site [chemical binding]; other site 526225011371 putative Mg++ binding site [ion binding]; other site 526225011372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225011373 nucleotide binding region [chemical binding]; other site 526225011374 ATP-binding site [chemical binding]; other site 526225011375 Helicase associated domain (HA2); Region: HA2; pfam04408 526225011376 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 526225011377 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 526225011378 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225011379 MarR family; Region: MarR; pfam01047 526225011380 MarR family; Region: MarR_2; cl17246 526225011381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225011382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225011383 putative substrate translocation pore; other site 526225011384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225011385 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 526225011386 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 526225011387 NAD binding site [chemical binding]; other site 526225011388 catalytic Zn binding site [ion binding]; other site 526225011389 structural Zn binding site [ion binding]; other site 526225011390 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 526225011391 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 526225011392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225011393 active site 526225011394 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 526225011395 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 526225011396 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 526225011397 Hemerythrin-like domain; Region: Hr-like; cd12108 526225011398 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 526225011399 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 526225011400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225011401 motif II; other site 526225011402 Asp23 family; Region: Asp23; pfam03780 526225011403 Asp23 family; Region: Asp23; pfam03780 526225011404 tetracycline repressor protein TetR; Provisional; Region: PRK13756 526225011405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225011406 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 526225011407 PRC-barrel domain; Region: PRC; pfam05239 526225011408 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 526225011409 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 526225011410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225011411 active site 526225011412 phosphorylation site [posttranslational modification] 526225011413 intermolecular recognition site; other site 526225011414 dimerization interface [polypeptide binding]; other site 526225011415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 526225011416 DNA binding site [nucleotide binding] 526225011417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225011418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 526225011419 dimerization interface [polypeptide binding]; other site 526225011420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225011421 dimer interface [polypeptide binding]; other site 526225011422 phosphorylation site [posttranslational modification] 526225011423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225011424 ATP binding site [chemical binding]; other site 526225011425 Mg2+ binding site [ion binding]; other site 526225011426 G-X-G motif; other site 526225011427 Domain of unknown function (DUF222); Region: DUF222; pfam02720 526225011428 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526225011429 active site 526225011430 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 526225011431 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 526225011432 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 526225011433 active site 526225011434 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 526225011435 homodimer interface [polypeptide binding]; other site 526225011436 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225011437 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225011438 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 526225011439 DXD motif; other site 526225011440 Low molecular weight phosphatase family; Region: LMWPc; cd00115 526225011441 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 526225011442 active site 526225011443 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 526225011444 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 526225011445 Multicopper oxidase; Region: Cu-oxidase; pfam00394 526225011446 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 526225011447 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225011448 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 526225011449 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 526225011450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225011451 putative DNA binding site [nucleotide binding]; other site 526225011452 putative Zn2+ binding site [ion binding]; other site 526225011453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 526225011454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225011455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225011456 putative substrate translocation pore; other site 526225011457 Low molecular weight phosphatase family; Region: LMWPc; cl00105 526225011458 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 526225011459 active site 526225011460 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 526225011461 Low molecular weight phosphatase family; Region: LMWPc; cd00115 526225011462 active site 526225011463 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 526225011464 Low molecular weight phosphatase family; Region: LMWPc; cl00105 526225011465 active site 526225011466 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 526225011467 arsenical-resistance protein; Region: acr3; TIGR00832 526225011468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225011469 dimerization interface [polypeptide binding]; other site 526225011470 putative DNA binding site [nucleotide binding]; other site 526225011471 putative Zn2+ binding site [ion binding]; other site 526225011472 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 526225011473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225011474 Coenzyme A binding pocket [chemical binding]; other site 526225011475 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 526225011476 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 526225011477 Int/Topo IB signature motif; other site 526225011478 potential protein location (hypothetical protein Gobs_4727 [Geodermatophilus obscurus DSM 43160]) that overlaps RNA (tRNA-K) 526225011479 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 526225011480 anti sigma factor interaction site; other site 526225011481 regulatory phosphorylation site [posttranslational modification]; other site 526225011482 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225011483 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225011484 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 526225011485 iron-sulfur cluster [ion binding]; other site 526225011486 [2Fe-2S] cluster binding site [ion binding]; other site 526225011487 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 526225011488 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 526225011489 active site 526225011490 metal binding site [ion binding]; metal-binding site 526225011491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 526225011492 Coenzyme A binding pocket [chemical binding]; other site 526225011493 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 526225011494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 526225011495 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225011496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225011497 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 526225011498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 526225011499 Transglycosylase; Region: Transgly; pfam00912 526225011500 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 526225011501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 526225011502 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 526225011503 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 526225011504 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 526225011505 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225011506 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 526225011507 Peptidase family M23; Region: Peptidase_M23; pfam01551 526225011508 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 526225011509 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 526225011510 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 526225011511 NAD binding site [chemical binding]; other site 526225011512 Phe binding site; other site 526225011513 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 526225011514 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 526225011515 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 526225011516 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 526225011517 dimerization interface [polypeptide binding]; other site 526225011518 putative ATP binding site [chemical binding]; other site 526225011519 amidophosphoribosyltransferase; Provisional; Region: PRK07847 526225011520 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 526225011521 active site 526225011522 tetramer interface [polypeptide binding]; other site 526225011523 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526225011524 active site 526225011525 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 526225011526 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 526225011527 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 526225011528 NAD binding site [chemical binding]; other site 526225011529 catalytic Zn binding site [ion binding]; other site 526225011530 substrate binding site [chemical binding]; other site 526225011531 structural Zn binding site [ion binding]; other site 526225011532 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 526225011533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225011534 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 526225011535 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 526225011536 dimerization interface [polypeptide binding]; other site 526225011537 ATP binding site [chemical binding]; other site 526225011538 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 526225011539 dimerization interface [polypeptide binding]; other site 526225011540 ATP binding site [chemical binding]; other site 526225011541 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 526225011542 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 526225011543 putative active site [active] 526225011544 catalytic triad [active] 526225011545 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 526225011546 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 526225011547 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 526225011548 putative active site [active] 526225011549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 526225011550 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 526225011551 ATP binding site [chemical binding]; other site 526225011552 active site 526225011553 substrate binding site [chemical binding]; other site 526225011554 adenylosuccinate lyase; Provisional; Region: PRK07492 526225011555 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 526225011556 tetramer interface [polypeptide binding]; other site 526225011557 active site 526225011558 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 526225011559 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 526225011560 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 526225011561 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 526225011562 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225011563 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 526225011564 GTPase RsgA; Reviewed; Region: PRK01889 526225011565 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 526225011566 GTPase/Zn-binding domain interface [polypeptide binding]; other site 526225011567 GTP/Mg2+ binding site [chemical binding]; other site 526225011568 G4 box; other site 526225011569 G5 box; other site 526225011570 G1 box; other site 526225011571 Switch I region; other site 526225011572 G2 box; other site 526225011573 G3 box; other site 526225011574 Switch II region; other site 526225011575 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 526225011576 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 526225011577 active site 526225011578 catalytic site [active] 526225011579 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 526225011580 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 526225011581 GDP-binding site [chemical binding]; other site 526225011582 ACT binding site; other site 526225011583 IMP binding site; other site 526225011584 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 526225011585 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 526225011586 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 526225011587 active site 526225011588 intersubunit interface [polypeptide binding]; other site 526225011589 zinc binding site [ion binding]; other site 526225011590 Na+ binding site [ion binding]; other site 526225011591 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 526225011592 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 526225011593 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 526225011594 active site 526225011595 Fasciclin domain; Region: Fasciclin; pfam02469 526225011596 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 526225011597 Fasciclin domain; Region: Fasciclin; pfam02469 526225011598 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 526225011599 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 526225011600 Moco binding site; other site 526225011601 metal coordination site [ion binding]; other site 526225011602 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 526225011603 Clp amino terminal domain; Region: Clp_N; pfam02861 526225011604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225011605 Walker A motif; other site 526225011606 ATP binding site [chemical binding]; other site 526225011607 Walker B motif; other site 526225011608 arginine finger; other site 526225011609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225011610 Walker A motif; other site 526225011611 ATP binding site [chemical binding]; other site 526225011612 Walker B motif; other site 526225011613 arginine finger; other site 526225011614 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 526225011615 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225011616 MarR family; Region: MarR; pfam01047 526225011617 OsmC-like protein; Region: OsmC; cl00767 526225011618 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 526225011619 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 526225011620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225011621 putative substrate translocation pore; other site 526225011622 MarR family; Region: MarR; pfam01047 526225011623 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 526225011624 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225011625 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225011626 malate synthase A; Region: malate_syn_A; TIGR01344 526225011627 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 526225011628 active site 526225011629 FAD binding domain; Region: FAD_binding_4; pfam01565 526225011630 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 526225011631 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 526225011632 FAD binding domain; Region: FAD_binding_4; pfam01565 526225011633 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 526225011634 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 526225011635 Cysteine-rich domain; Region: CCG; pfam02754 526225011636 Cysteine-rich domain; Region: CCG; pfam02754 526225011637 glycolate transporter; Provisional; Region: PRK09695 526225011638 L-lactate permease; Region: Lactate_perm; cl00701 526225011639 L-lactate permease; Region: Lactate_perm; cl00701 526225011640 Transcriptional regulators [Transcription]; Region: MarR; COG1846 526225011641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225011642 putative DNA binding site [nucleotide binding]; other site 526225011643 putative Zn2+ binding site [ion binding]; other site 526225011644 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 526225011645 DNA binding residues [nucleotide binding] 526225011646 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225011647 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 526225011648 HSP70 interaction site [polypeptide binding]; other site 526225011649 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 526225011650 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 526225011651 Zn binding sites [ion binding]; other site 526225011652 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 526225011653 dimer interface [polypeptide binding]; other site 526225011654 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 526225011655 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 526225011656 dimer interface [polypeptide binding]; other site 526225011657 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 526225011658 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 526225011659 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 526225011660 nucleotide binding site [chemical binding]; other site 526225011661 NEF interaction site [polypeptide binding]; other site 526225011662 SBD interface [polypeptide binding]; other site 526225011663 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 526225011664 4Fe-4S binding domain; Region: Fer4; pfam00037 526225011665 Cysteine-rich domain; Region: CCG; pfam02754 526225011666 Cysteine-rich domain; Region: CCG; pfam02754 526225011667 cyanate transporter; Region: CynX; TIGR00896 526225011668 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 526225011669 trimer interface [polypeptide binding]; other site 526225011670 active site 526225011671 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 526225011672 catalytic triad [active] 526225011673 putative active site [active] 526225011674 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 526225011675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 526225011676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 526225011677 dimer interface [polypeptide binding]; other site 526225011678 phosphorylation site [posttranslational modification] 526225011679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225011680 ATP binding site [chemical binding]; other site 526225011681 Mg2+ binding site [ion binding]; other site 526225011682 G-X-G motif; other site 526225011683 Response regulator receiver domain; Region: Response_reg; pfam00072 526225011684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225011685 active site 526225011686 phosphorylation site [posttranslational modification] 526225011687 intermolecular recognition site; other site 526225011688 dimerization interface [polypeptide binding]; other site 526225011689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 526225011690 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 526225011691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 526225011692 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 526225011693 GAF domain; Region: GAF_2; pfam13185 526225011694 GAF domain; Region: GAF; pfam01590 526225011695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225011696 Histidine kinase; Region: HisKA_3; pfam07730 526225011697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225011698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225011699 active site 526225011700 phosphorylation site [posttranslational modification] 526225011701 intermolecular recognition site; other site 526225011702 dimerization interface [polypeptide binding]; other site 526225011703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225011704 DNA binding residues [nucleotide binding] 526225011705 dimerization interface [polypeptide binding]; other site 526225011706 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 526225011707 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 526225011708 malonyl-CoA binding site [chemical binding]; other site 526225011709 dimer interface [polypeptide binding]; other site 526225011710 active site 526225011711 product binding site; other site 526225011712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225011713 S-adenosylmethionine binding site [chemical binding]; other site 526225011714 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 526225011715 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 526225011716 substrate binding site [chemical binding]; other site 526225011717 ATP binding site [chemical binding]; other site 526225011718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 526225011719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225011720 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 526225011721 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 526225011722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225011723 active site 526225011724 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 526225011725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225011726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225011727 active site 526225011728 phosphorylation site [posttranslational modification] 526225011729 intermolecular recognition site; other site 526225011730 dimerization interface [polypeptide binding]; other site 526225011731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225011732 DNA binding residues [nucleotide binding] 526225011733 dimerization interface [polypeptide binding]; other site 526225011734 Histidine kinase; Region: HisKA_3; pfam07730 526225011735 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 526225011736 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 526225011737 ABC-2 type transporter; Region: ABC2_membrane; cl17235 526225011738 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 526225011739 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 526225011740 Walker A/P-loop; other site 526225011741 ATP binding site [chemical binding]; other site 526225011742 Q-loop/lid; other site 526225011743 ABC transporter signature motif; other site 526225011744 Walker B; other site 526225011745 D-loop; other site 526225011746 H-loop/switch region; other site 526225011747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225011748 short chain dehydrogenase; Provisional; Region: PRK07577 526225011749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 526225011750 active site 526225011751 GAF domain; Region: GAF; pfam01590 526225011752 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225011753 Tannase and feruloyl esterase; Region: Tannase; pfam07519 526225011754 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 526225011755 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 526225011756 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225011757 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225011758 metal binding site [ion binding]; metal-binding site 526225011759 active site 526225011760 I-site; other site 526225011761 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 526225011762 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 526225011763 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 526225011764 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526225011765 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 526225011766 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 526225011767 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 526225011768 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 526225011769 putative substrate binding site [chemical binding]; other site 526225011770 putative ATP binding site [chemical binding]; other site 526225011771 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 526225011772 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 526225011773 active site 526225011774 phosphorylation site [posttranslational modification] 526225011775 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 526225011776 active site 526225011777 P-loop; other site 526225011778 phosphorylation site [posttranslational modification] 526225011779 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 526225011780 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 526225011781 dimerization domain swap beta strand [polypeptide binding]; other site 526225011782 regulatory protein interface [polypeptide binding]; other site 526225011783 active site 526225011784 regulatory phosphorylation site [posttranslational modification]; other site 526225011785 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 526225011786 putative hydrophobic ligand binding site [chemical binding]; other site 526225011787 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 526225011788 putative active cleft [active] 526225011789 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 526225011790 E3 interaction surface; other site 526225011791 lipoyl attachment site [posttranslational modification]; other site 526225011792 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 526225011793 e3 binding domain; Region: E3_binding; pfam02817 526225011794 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 526225011795 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 526225011796 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 526225011797 alpha subunit interface [polypeptide binding]; other site 526225011798 TPP binding site [chemical binding]; other site 526225011799 heterodimer interface [polypeptide binding]; other site 526225011800 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 526225011801 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 526225011802 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 526225011803 TPP-binding site [chemical binding]; other site 526225011804 heterodimer interface [polypeptide binding]; other site 526225011805 tetramer interface [polypeptide binding]; other site 526225011806 phosphorylation loop region [posttranslational modification] 526225011807 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 526225011808 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 526225011809 AsnC family; Region: AsnC_trans_reg; pfam01037 526225011810 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 526225011811 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 526225011812 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 526225011813 Beta-lactamase; Region: Beta-lactamase; pfam00144 526225011814 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 526225011815 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 526225011816 NlpC/P60 family; Region: NLPC_P60; pfam00877 526225011817 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 526225011818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 526225011819 Transglycosylase; Region: Transgly; pfam00912 526225011820 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 526225011821 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 526225011822 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 526225011823 Part of AAA domain; Region: AAA_19; pfam13245 526225011824 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 526225011825 active site residue [active] 526225011826 Major Facilitator Superfamily; Region: MFS_1; pfam07690 526225011827 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 526225011828 active site 526225011829 substrate-binding site [chemical binding]; other site 526225011830 metal-binding site [ion binding] 526225011831 GTP binding site [chemical binding]; other site 526225011832 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 526225011833 putative hydrophobic ligand binding site [chemical binding]; other site 526225011834 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225011835 dimerization interface [polypeptide binding]; other site 526225011836 putative DNA binding site [nucleotide binding]; other site 526225011837 putative Zn2+ binding site [ion binding]; other site 526225011838 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 526225011839 FMN binding site [chemical binding]; other site 526225011840 substrate binding site [chemical binding]; other site 526225011841 putative catalytic residue [active] 526225011842 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 526225011843 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 526225011844 catalytic residues [active] 526225011845 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 526225011846 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 526225011847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225011848 classical (c) SDRs; Region: SDR_c; cd05233 526225011849 NAD(P) binding site [chemical binding]; other site 526225011850 active site 526225011851 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 526225011852 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 526225011853 Ca binding site [ion binding]; other site 526225011854 active site 526225011855 catalytic site [active] 526225011856 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 526225011857 H+ Antiporter protein; Region: 2A0121; TIGR00900 526225011858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225011859 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 526225011860 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 526225011861 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 526225011862 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 526225011863 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 526225011864 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 526225011865 acyl-activating enzyme (AAE) consensus motif; other site 526225011866 putative AMP binding site [chemical binding]; other site 526225011867 putative active site [active] 526225011868 putative CoA binding site [chemical binding]; other site 526225011869 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 526225011870 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 526225011871 catalytic residues [active] 526225011872 dimer interface [polypeptide binding]; other site 526225011873 EamA-like transporter family; Region: EamA; pfam00892 526225011874 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 526225011875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 526225011876 BCCT family transporter; Region: BCCT; pfam02028 526225011877 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 526225011878 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 526225011879 Mechanosensitive ion channel; Region: MS_channel; pfam00924 526225011880 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 526225011881 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 526225011882 NAD(P) binding site [chemical binding]; other site 526225011883 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 526225011884 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 526225011885 homodimer interface [polypeptide binding]; other site 526225011886 substrate-cofactor binding pocket; other site 526225011887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225011888 catalytic residue [active] 526225011889 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 526225011890 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 526225011891 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 526225011892 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 526225011893 trimer interface [polypeptide binding]; other site 526225011894 putative metal binding site [ion binding]; other site 526225011895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 526225011896 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 526225011897 NlpC/P60 family; Region: NLPC_P60; pfam00877 526225011898 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 526225011899 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 526225011900 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 526225011901 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 526225011902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 526225011903 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 526225011904 homotrimer interaction site [polypeptide binding]; other site 526225011905 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 526225011906 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 526225011907 active site 526225011908 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 526225011909 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 526225011910 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 526225011911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 526225011912 motif II; other site 526225011913 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 526225011914 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 526225011915 putative hydrophobic ligand binding site [chemical binding]; other site 526225011916 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 526225011917 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 526225011918 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 526225011919 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 526225011920 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 526225011921 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 526225011922 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225011923 catalytic loop [active] 526225011924 iron binding site [ion binding]; other site 526225011925 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 526225011926 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 526225011927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 526225011928 putative substrate translocation pore; other site 526225011929 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 526225011930 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 526225011931 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 526225011932 active site 526225011933 Isochorismatase family; Region: Isochorismatase; pfam00857 526225011934 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 526225011935 catalytic triad [active] 526225011936 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 526225011937 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 526225011938 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225011939 phosphate binding site [ion binding]; other site 526225011940 hypothetical protein; Provisional; Region: PRK04233 526225011941 SEC-C motif; Region: SEC-C; pfam02810 526225011942 Domain of unknown function (DUF222); Region: DUF222; pfam02720 526225011943 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 526225011944 active site 526225011945 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 526225011946 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 526225011947 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996 526225011948 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 526225011949 phosphate binding site [ion binding]; other site 526225011950 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 526225011951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225011952 FeS/SAM binding site; other site 526225011953 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 526225011954 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 526225011955 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 526225011956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 526225011957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225011958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225011959 active site 526225011960 catalytic tetrad [active] 526225011961 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 526225011962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225011963 active site 526225011964 phosphorylation site [posttranslational modification] 526225011965 intermolecular recognition site; other site 526225011966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 526225011967 DNA binding residues [nucleotide binding] 526225011968 dimerization interface [polypeptide binding]; other site 526225011969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 526225011970 Histidine kinase; Region: HisKA_3; pfam07730 526225011971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225011972 ATP binding site [chemical binding]; other site 526225011973 Mg2+ binding site [ion binding]; other site 526225011974 G-X-G motif; other site 526225011975 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 526225011976 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 526225011977 active site 526225011978 NAD binding site [chemical binding]; other site 526225011979 metal binding site [ion binding]; metal-binding site 526225011980 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 526225011981 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 526225011982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 526225011983 catalytic residue [active] 526225011984 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 526225011985 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225011986 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 526225011987 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 526225011988 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 526225011989 NAD binding site [chemical binding]; other site 526225011990 catalytic Zn binding site [ion binding]; other site 526225011991 substrate binding site [chemical binding]; other site 526225011992 structural Zn binding site [ion binding]; other site 526225011993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225011994 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 526225011995 Walker A motif; other site 526225011996 ATP binding site [chemical binding]; other site 526225011997 Walker B motif; other site 526225011998 arginine finger; other site 526225011999 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 526225012000 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 526225012001 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 526225012002 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 526225012003 XdhC Rossmann domain; Region: XdhC_C; pfam13478 526225012004 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 526225012005 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 526225012006 metal ion-dependent adhesion site (MIDAS); other site 526225012007 MoxR-like ATPases [General function prediction only]; Region: COG0714 526225012008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 526225012009 Walker A motif; other site 526225012010 ATP binding site [chemical binding]; other site 526225012011 Walker B motif; other site 526225012012 arginine finger; other site 526225012013 PRC-barrel domain; Region: PRC; pfam05239 526225012014 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 526225012015 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 526225012016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225012017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225012018 active site 526225012019 catalytic tetrad [active] 526225012020 hypothetical protein; Provisional; Region: PRK01346 526225012021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 526225012022 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 526225012023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 526225012024 FeS/SAM binding site; other site 526225012025 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 526225012026 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 526225012027 MoaE interaction surface [polypeptide binding]; other site 526225012028 MoeB interaction surface [polypeptide binding]; other site 526225012029 thiocarboxylated glycine; other site 526225012030 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225012031 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 526225012032 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 526225012033 MoaD interaction [polypeptide binding]; other site 526225012034 active site residues [active] 526225012035 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 526225012036 metal-binding site 526225012037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 526225012038 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 526225012039 Walker A/P-loop; other site 526225012040 ATP binding site [chemical binding]; other site 526225012041 Q-loop/lid; other site 526225012042 ABC transporter signature motif; other site 526225012043 Walker B; other site 526225012044 D-loop; other site 526225012045 H-loop/switch region; other site 526225012046 TOBE domain; Region: TOBE; pfam03459 526225012047 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 526225012048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 526225012049 dimer interface [polypeptide binding]; other site 526225012050 conserved gate region; other site 526225012051 putative PBP binding loops; other site 526225012052 ABC-ATPase subunit interface; other site 526225012053 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 526225012054 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 526225012055 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 526225012056 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 526225012057 DNA binding residues [nucleotide binding] 526225012058 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 526225012059 MASE1; Region: MASE1; cl17823 526225012060 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225012061 metal binding site [ion binding]; metal-binding site 526225012062 active site 526225012063 I-site; other site 526225012064 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 526225012065 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 526225012066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225012067 ATP binding site [chemical binding]; other site 526225012068 putative Mg++ binding site [ion binding]; other site 526225012069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 526225012070 nucleotide binding region [chemical binding]; other site 526225012071 ATP-binding site [chemical binding]; other site 526225012072 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 526225012073 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 526225012074 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 526225012075 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 526225012076 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 526225012077 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 526225012078 active site 526225012079 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 526225012080 Transcriptional regulator [Transcription]; Region: LytR; COG1316 526225012081 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 526225012082 putative catalytic site [active] 526225012083 putative phosphate binding site [ion binding]; other site 526225012084 active site 526225012085 metal binding site A [ion binding]; metal-binding site 526225012086 DNA binding site [nucleotide binding] 526225012087 putative AP binding site [nucleotide binding]; other site 526225012088 putative metal binding site B [ion binding]; other site 526225012089 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 526225012090 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 526225012091 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 526225012092 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 526225012093 NAD binding site [chemical binding]; other site 526225012094 catalytic Zn binding site [ion binding]; other site 526225012095 structural Zn binding site [ion binding]; other site 526225012096 hypothetical protein; Validated; Region: PRK02101 526225012097 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225012098 GAF domain; Region: GAF; pfam01590 526225012099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225012100 PAS fold; Region: PAS_3; pfam08447 526225012101 putative active site [active] 526225012102 heme pocket [chemical binding]; other site 526225012103 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225012104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 526225012105 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225012106 amidase; Provisional; Region: PRK07486 526225012107 Amidase; Region: Amidase; pfam01425 526225012108 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 526225012109 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 526225012110 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 526225012111 Membrane protein of unknown function; Region: DUF360; pfam04020 526225012112 Protein of unknown function, DUF393; Region: DUF393; pfam04134 526225012113 AAA ATPase domain; Region: AAA_16; pfam13191 526225012114 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 526225012115 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 526225012116 GAF domain; Region: GAF; pfam01590 526225012117 GAF domain; Region: GAF_2; pfam13185 526225012118 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225012119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225012120 ATP binding site [chemical binding]; other site 526225012121 Mg2+ binding site [ion binding]; other site 526225012122 G-X-G motif; other site 526225012123 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 526225012124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225012125 active site 526225012126 phosphorylation site [posttranslational modification] 526225012127 intermolecular recognition site; other site 526225012128 dimerization interface [polypeptide binding]; other site 526225012129 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 526225012130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225012131 Response regulator receiver domain; Region: Response_reg; pfam00072 526225012132 active site 526225012133 phosphorylation site [posttranslational modification] 526225012134 intermolecular recognition site; other site 526225012135 dimerization interface [polypeptide binding]; other site 526225012136 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 526225012137 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 526225012138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225012139 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 526225012140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 526225012141 active site 526225012142 phosphorylation site [posttranslational modification] 526225012143 intermolecular recognition site; other site 526225012144 dimerization interface [polypeptide binding]; other site 526225012145 CheB methylesterase; Region: CheB_methylest; pfam01339 526225012146 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 526225012147 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 526225012148 oligomer interface; other site 526225012149 ligand binding site; other site 526225012150 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 526225012151 dimer interface [polypeptide binding]; other site 526225012152 N-terminal domain interface [polypeptide binding]; other site 526225012153 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 526225012154 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 526225012155 putative binding surface; other site 526225012156 active site 526225012157 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 526225012158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 526225012159 ATP binding site [chemical binding]; other site 526225012160 Mg2+ binding site [ion binding]; other site 526225012161 G-X-G motif; other site 526225012162 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 526225012163 CheW-like domain; Region: CheW; pfam01584 526225012164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526225012165 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 526225012166 dimer interface [polypeptide binding]; other site 526225012167 putative CheW interface [polypeptide binding]; other site 526225012168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526225012169 dimerization interface [polypeptide binding]; other site 526225012170 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526225012171 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 526225012172 dimer interface [polypeptide binding]; other site 526225012173 putative CheW interface [polypeptide binding]; other site 526225012174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 526225012175 dimerization interface [polypeptide binding]; other site 526225012176 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 526225012177 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 526225012178 dimer interface [polypeptide binding]; other site 526225012179 putative CheW interface [polypeptide binding]; other site 526225012180 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 526225012181 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 526225012182 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 526225012183 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 526225012184 active site 526225012185 homotetramer interface [polypeptide binding]; other site 526225012186 CrcB-like protein; Region: CRCB; pfam02537 526225012187 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 526225012188 Integral membrane protein TerC family; Region: TerC; cl10468 526225012189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225012190 putative Zn2+ binding site [ion binding]; other site 526225012191 putative DNA binding site [nucleotide binding]; other site 526225012192 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 526225012193 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 526225012194 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225012195 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 526225012196 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 526225012197 active site 526225012198 dimer interface [polypeptide binding]; other site 526225012199 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 526225012200 Ligand Binding Site [chemical binding]; other site 526225012201 Molecular Tunnel; other site 526225012202 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 526225012203 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 526225012204 NADP binding site [chemical binding]; other site 526225012205 dimer interface [polypeptide binding]; other site 526225012206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 526225012207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 526225012208 non-specific DNA binding site [nucleotide binding]; other site 526225012209 salt bridge; other site 526225012210 sequence-specific DNA binding site [nucleotide binding]; other site 526225012211 SnoaL-like domain; Region: SnoaL_2; pfam12680 526225012212 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 526225012213 TAP-like protein; Region: Abhydrolase_4; pfam08386 526225012214 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 526225012215 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 526225012216 Walker A/P-loop; other site 526225012217 ATP binding site [chemical binding]; other site 526225012218 Q-loop/lid; other site 526225012219 ABC transporter signature motif; other site 526225012220 Walker B; other site 526225012221 D-loop; other site 526225012222 H-loop/switch region; other site 526225012223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 526225012224 ABC-ATPase subunit interface; other site 526225012225 dimer interface [polypeptide binding]; other site 526225012226 putative PBP binding regions; other site 526225012227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 526225012228 ABC-ATPase subunit interface; other site 526225012229 dimer interface [polypeptide binding]; other site 526225012230 putative PBP binding regions; other site 526225012231 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 526225012232 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 526225012233 putative ligand binding residues [chemical binding]; other site 526225012234 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 526225012235 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 526225012236 active site 526225012237 catalytic tetrad [active] 526225012238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225012239 PAS domain; Region: PAS_9; pfam13426 526225012240 putative active site [active] 526225012241 heme pocket [chemical binding]; other site 526225012242 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 526225012243 GAF domain; Region: GAF; pfam01590 526225012244 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 526225012245 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 526225012246 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 526225012247 active site 526225012248 catalytic residues [active] 526225012249 metal binding site [ion binding]; metal-binding site 526225012250 PAS domain S-box; Region: sensory_box; TIGR00229 526225012251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 526225012252 putative active site [active] 526225012253 heme pocket [chemical binding]; other site 526225012254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 526225012255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 526225012256 metal binding site [ion binding]; metal-binding site 526225012257 active site 526225012258 I-site; other site 526225012259 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 526225012260 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 526225012261 metal binding site [ion binding]; metal-binding site 526225012262 dimer interface [polypeptide binding]; other site 526225012263 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 526225012264 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 526225012265 Transcriptional regulator [Transcription]; Region: IclR; COG1414 526225012266 Bacterial transcriptional regulator; Region: IclR; pfam01614 526225012267 glycerol kinase; Provisional; Region: glpK; PRK00047 526225012268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 526225012269 nucleotide binding site [chemical binding]; other site 526225012270 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 526225012271 amphipathic channel; other site 526225012272 Asn-Pro-Ala signature motifs; other site 526225012273 glycerol kinase; Provisional; Region: glpK; PRK00047 526225012274 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 526225012275 N- and C-terminal domain interface [polypeptide binding]; other site 526225012276 active site 526225012277 MgATP binding site [chemical binding]; other site 526225012278 catalytic site [active] 526225012279 metal binding site [ion binding]; metal-binding site 526225012280 putative homotetramer interface [polypeptide binding]; other site 526225012281 glycerol binding site [chemical binding]; other site 526225012282 homodimer interface [polypeptide binding]; other site 526225012283 phosphoglucomutase; Validated; Region: PRK07564 526225012284 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 526225012285 active site 526225012286 substrate binding site [chemical binding]; other site 526225012287 metal binding site [ion binding]; metal-binding site 526225012288 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 526225012289 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 526225012290 FMN binding site [chemical binding]; other site 526225012291 dimer interface [polypeptide binding]; other site 526225012292 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 526225012293 PGAP1-like protein; Region: PGAP1; pfam07819 526225012294 acyl-CoA esterase; Provisional; Region: PRK10673 526225012295 DEAD-like helicases superfamily; Region: DEXDc; smart00487 526225012296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 526225012297 ATP binding site [chemical binding]; other site 526225012298 putative Mg++ binding site [ion binding]; other site 526225012299 Helicase_C-like; Region: Helicase_C_4; pfam13871 526225012300 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 526225012301 thiamine phosphate binding site [chemical binding]; other site 526225012302 active site 526225012303 pyrophosphate binding site [ion binding]; other site 526225012304 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 526225012305 dimer interface [polypeptide binding]; other site 526225012306 substrate binding site [chemical binding]; other site 526225012307 ATP binding site [chemical binding]; other site 526225012308 DNA polymerase IV; Provisional; Region: PRK03348 526225012309 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 526225012310 active site 526225012311 DNA binding site [nucleotide binding] 526225012312 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 526225012313 Cation efflux family; Region: Cation_efflux; cl00316 526225012314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 526225012315 dimerization interface [polypeptide binding]; other site 526225012316 putative DNA binding site [nucleotide binding]; other site 526225012317 putative Zn2+ binding site [ion binding]; other site 526225012318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225012319 S-adenosylmethionine binding site [chemical binding]; other site 526225012320 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 526225012321 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 526225012322 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 526225012323 FAD binding pocket [chemical binding]; other site 526225012324 FAD binding motif [chemical binding]; other site 526225012325 phosphate binding motif [ion binding]; other site 526225012326 beta-alpha-beta structure motif; other site 526225012327 NAD binding pocket [chemical binding]; other site 526225012328 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 526225012329 catalytic loop [active] 526225012330 iron binding site [ion binding]; other site 526225012331 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 526225012332 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 526225012333 putative di-iron ligands [ion binding]; other site 526225012334 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 526225012335 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 526225012336 Walker A motif; other site 526225012337 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 526225012338 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 526225012339 replicative DNA helicase; Region: DnaB; TIGR00665 526225012340 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 526225012341 ATP binding site [chemical binding]; other site 526225012342 Walker B motif; other site 526225012343 DNA binding loops [nucleotide binding] 526225012344 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 526225012345 homotrimer interaction site [polypeptide binding]; other site 526225012346 putative active site [active] 526225012347 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 526225012348 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 526225012349 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 526225012350 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 526225012351 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 526225012352 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 526225012353 dimer interface [polypeptide binding]; other site 526225012354 ssDNA binding site [nucleotide binding]; other site 526225012355 tetramer (dimer of dimers) interface [polypeptide binding]; other site 526225012356 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 526225012357 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 526225012358 endonuclease IV; Provisional; Region: PRK01060 526225012359 AP (apurinic/apyrimidinic) site pocket; other site 526225012360 DNA interaction; other site 526225012361 Metal-binding active site; metal-binding site 526225012362 Predicted integral membrane protein [Function unknown]; Region: COG5650 526225012363 Predicted integral membrane protein [Function unknown]; Region: COG5650 526225012364 Transglycosylase; Region: Transgly; pfam00912 526225012365 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 526225012366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 526225012367 Predicted transcriptional regulators [Transcription]; Region: COG1695 526225012368 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 526225012369 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 526225012370 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 526225012371 hypothetical protein; Validated; Region: PRK00228 526225012372 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 526225012373 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 526225012374 active site 526225012375 NTP binding site [chemical binding]; other site 526225012376 metal binding triad [ion binding]; metal-binding site 526225012377 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 526225012378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 526225012379 Zn2+ binding site [ion binding]; other site 526225012380 Mg2+ binding site [ion binding]; other site 526225012381 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 526225012382 active site 526225012383 Ap6A binding site [chemical binding]; other site 526225012384 nudix motif; other site 526225012385 metal binding site [ion binding]; metal-binding site 526225012386 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 526225012387 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 526225012388 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 526225012389 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 526225012390 active site 526225012391 ATP binding site [chemical binding]; other site 526225012392 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 526225012393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 526225012394 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 526225012395 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 526225012396 catalytic residues [active] 526225012397 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 526225012398 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 526225012399 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 526225012400 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 526225012401 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 526225012402 active site 526225012403 metal binding site [ion binding]; metal-binding site 526225012404 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 526225012405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 526225012406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 526225012407 homodimer interface [polypeptide binding]; other site 526225012408 catalytic residue [active] 526225012409 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 526225012410 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 526225012411 ATP-grasp domain; Region: ATP-grasp_4; cl17255 526225012412 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 526225012413 ParB-like nuclease domain; Region: ParBc; pfam02195 526225012414 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 526225012415 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526225012416 P-loop; other site 526225012417 Magnesium ion binding site [ion binding]; other site 526225012418 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 526225012419 Magnesium ion binding site [ion binding]; other site 526225012420 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 526225012421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 526225012422 S-adenosylmethionine binding site [chemical binding]; other site 526225012423 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 526225012424 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 526225012425 G-X-X-G motif; other site 526225012426 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 526225012427 RxxxH motif; other site 526225012428 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 526225012429 Haemolytic domain; Region: Haemolytic; pfam01809 526225012430 Ribonuclease P; Region: Ribonuclease_P; cl00457 526225012431 Ribosomal protein L34; Region: Ribosomal_L34; cl00370