-- dump date 20140619_102735 -- class Genbank::misc_feature -- table misc_feature_note -- id note 983545000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 983545000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 983545000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545000004 Walker A motif; other site 983545000005 ATP binding site [chemical binding]; other site 983545000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 983545000007 Walker B motif; other site 983545000008 arginine finger; other site 983545000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 983545000010 DnaA box-binding interface [nucleotide binding]; other site 983545000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 983545000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 983545000013 putative DNA binding surface [nucleotide binding]; other site 983545000014 dimer interface [polypeptide binding]; other site 983545000015 beta-clamp/clamp loader binding surface; other site 983545000016 beta-clamp/translesion DNA polymerase binding surface; other site 983545000017 recombination protein F; Reviewed; Region: recF; PRK00064 983545000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545000019 Walker A/P-loop; other site 983545000020 ATP binding site [chemical binding]; other site 983545000021 Q-loop/lid; other site 983545000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545000023 ABC transporter signature motif; other site 983545000024 Walker B; other site 983545000025 D-loop; other site 983545000026 H-loop/switch region; other site 983545000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 983545000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000029 Mg2+ binding site [ion binding]; other site 983545000030 G-X-G motif; other site 983545000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 983545000032 anchoring element; other site 983545000033 dimer interface [polypeptide binding]; other site 983545000034 ATP binding site [chemical binding]; other site 983545000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 983545000036 active site 983545000037 putative metal-binding site [ion binding]; other site 983545000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 983545000039 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 983545000040 aspartate racemase; Region: asp_race; TIGR00035 983545000041 HAMP domain; Region: HAMP; pfam00672 983545000042 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545000043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000044 metal binding site [ion binding]; metal-binding site 983545000045 active site 983545000046 I-site; other site 983545000047 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 983545000048 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 983545000049 DALR anticodon binding domain; Region: DALR_1; pfam05746 983545000050 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 983545000051 dimer interface [polypeptide binding]; other site 983545000052 motif 1; other site 983545000053 active site 983545000054 motif 2; other site 983545000055 motif 3; other site 983545000056 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 983545000057 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 983545000058 Der GTPase activator; Provisional; Region: PRK05244 983545000059 Cytochrome c553 [Energy production and conversion]; Region: COG2863 983545000060 Cytochrome c; Region: Cytochrom_C; cl11414 983545000061 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 983545000062 G1 box; other site 983545000063 GTP/Mg2+ binding site [chemical binding]; other site 983545000064 Switch I region; other site 983545000065 G2 box; other site 983545000066 G3 box; other site 983545000067 Switch II region; other site 983545000068 G4 box; other site 983545000069 G5 box; other site 983545000070 DNA polymerase I; Provisional; Region: PRK05755 983545000071 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 983545000072 active site 983545000073 metal binding site 1 [ion binding]; metal-binding site 983545000074 putative 5' ssDNA interaction site; other site 983545000075 metal binding site 3; metal-binding site 983545000076 metal binding site 2 [ion binding]; metal-binding site 983545000077 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 983545000078 putative DNA binding site [nucleotide binding]; other site 983545000079 putative metal binding site [ion binding]; other site 983545000080 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 983545000081 active site 983545000082 catalytic site [active] 983545000083 substrate binding site [chemical binding]; other site 983545000084 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 983545000085 active site 983545000086 DNA binding site [nucleotide binding] 983545000087 catalytic site [active] 983545000088 Cation transport protein; Region: TrkH; cl17365 983545000089 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 983545000090 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 983545000091 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 983545000092 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 983545000093 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 983545000094 TrkA-N domain; Region: TrkA_N; pfam02254 983545000095 TrkA-C domain; Region: TrkA_C; pfam02080 983545000096 TrkA-N domain; Region: TrkA_N; pfam02254 983545000097 TrkA-C domain; Region: TrkA_C; pfam02080 983545000098 16S rRNA methyltransferase B; Provisional; Region: PRK10901 983545000099 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 983545000100 putative RNA binding site [nucleotide binding]; other site 983545000101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000102 S-adenosylmethionine binding site [chemical binding]; other site 983545000103 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 983545000104 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 983545000105 putative active site [active] 983545000106 substrate binding site [chemical binding]; other site 983545000107 putative cosubstrate binding site; other site 983545000108 catalytic site [active] 983545000109 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 983545000110 substrate binding site [chemical binding]; other site 983545000111 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 983545000112 active site 983545000113 catalytic residues [active] 983545000114 metal binding site [ion binding]; metal-binding site 983545000115 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983545000116 hypothetical protein; Provisional; Region: PRK10736 983545000117 DNA protecting protein DprA; Region: dprA; TIGR00732 983545000118 hypothetical protein; Validated; Region: PRK03430 983545000119 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 983545000120 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 983545000121 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 983545000122 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 983545000123 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 983545000124 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 983545000125 OmpW family; Region: OmpW; cl17427 983545000126 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 983545000127 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 983545000128 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 983545000129 shikimate binding site; other site 983545000130 NAD(P) binding site [chemical binding]; other site 983545000131 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 983545000132 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 983545000133 trimer interface [polypeptide binding]; other site 983545000134 putative metal binding site [ion binding]; other site 983545000135 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 983545000136 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 983545000137 putative active site [active] 983545000138 putative PHP Thumb interface [polypeptide binding]; other site 983545000139 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 983545000140 generic binding surface II; other site 983545000141 generic binding surface I; other site 983545000142 DNA Polymerase Y-family; Region: PolY_like; cd03468 983545000143 active site 983545000144 DNA binding site [nucleotide binding] 983545000145 Uncharacterized conserved protein [Function unknown]; Region: COG4544 983545000146 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 983545000147 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545000148 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545000149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000150 metal binding site [ion binding]; metal-binding site 983545000151 active site 983545000152 I-site; other site 983545000153 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983545000154 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545000155 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545000156 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545000157 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 983545000158 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545000159 active site 983545000160 metal binding site [ion binding]; metal-binding site 983545000161 Phytase; Region: Phytase; cl17685 983545000162 Phytase; Region: Phytase; cl17685 983545000163 EVE domain; Region: EVE; cl00728 983545000164 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545000165 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 983545000166 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545000167 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 983545000168 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545000169 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 983545000170 Peptidase family M28; Region: Peptidase_M28; pfam04389 983545000171 metal binding site [ion binding]; metal-binding site 983545000172 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545000173 division inhibitor protein; Provisional; Region: slmA; PRK09480 983545000174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545000175 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 983545000176 Flavoprotein; Region: Flavoprotein; pfam02441 983545000177 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 983545000178 hypothetical protein; Reviewed; Region: PRK00024 983545000179 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 983545000180 MPN+ (JAMM) motif; other site 983545000181 Zinc-binding site [ion binding]; other site 983545000182 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983545000183 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 983545000184 Substrate binding site; other site 983545000185 metal-binding site 983545000186 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 983545000187 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 983545000188 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 983545000189 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 983545000190 DNA binding site [nucleotide binding] 983545000191 catalytic residue [active] 983545000192 H2TH interface [polypeptide binding]; other site 983545000193 putative catalytic residues [active] 983545000194 turnover-facilitating residue; other site 983545000195 intercalation triad [nucleotide binding]; other site 983545000196 8OG recognition residue [nucleotide binding]; other site 983545000197 putative reading head residues; other site 983545000198 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 983545000199 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 983545000200 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 983545000201 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 983545000202 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 983545000203 active site 983545000204 (T/H)XGH motif; other site 983545000205 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 983545000206 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 983545000207 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 983545000208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545000209 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545000210 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 983545000211 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 983545000212 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545000213 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545000214 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000215 metal binding site [ion binding]; metal-binding site 983545000216 active site 983545000217 I-site; other site 983545000218 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000219 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 983545000220 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 983545000221 substrate-cofactor binding pocket; other site 983545000222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000223 catalytic residue [active] 983545000224 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 983545000225 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 983545000226 NAD(P) binding site [chemical binding]; other site 983545000227 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 983545000228 active site residue [active] 983545000229 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 983545000230 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 983545000231 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 983545000232 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 983545000233 Chorismate lyase; Region: Chor_lyase; cl01230 983545000234 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 983545000235 UbiA prenyltransferase family; Region: UbiA; pfam01040 983545000236 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 983545000237 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545000238 dimerization interface [polypeptide binding]; other site 983545000239 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545000240 dimer interface [polypeptide binding]; other site 983545000241 putative CheW interface [polypeptide binding]; other site 983545000242 Membrane fusogenic activity; Region: BMFP; pfam04380 983545000243 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 983545000244 Part of AAA domain; Region: AAA_19; pfam13245 983545000245 Family description; Region: UvrD_C_2; pfam13538 983545000246 GAF domain; Region: GAF; pfam01590 983545000247 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545000248 GAF domain; Region: GAF_3; pfam13492 983545000249 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545000250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000251 metal binding site [ion binding]; metal-binding site 983545000252 active site 983545000253 I-site; other site 983545000254 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000255 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 983545000256 DNA ligase; Provisional; Region: PRK09125 983545000257 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 983545000258 DNA binding site [nucleotide binding] 983545000259 active site 983545000260 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 983545000261 DNA binding site [nucleotide binding] 983545000262 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545000263 PGAP1-like protein; Region: PGAP1; pfam07819 983545000264 oxidative damage protection protein; Provisional; Region: PRK05408 983545000265 adenine DNA glycosylase; Provisional; Region: PRK10880 983545000266 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 983545000267 minor groove reading motif; other site 983545000268 helix-hairpin-helix signature motif; other site 983545000269 substrate binding pocket [chemical binding]; other site 983545000270 active site 983545000271 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 983545000272 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 983545000273 DNA binding and oxoG recognition site [nucleotide binding] 983545000274 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545000275 Methyltransferase domain; Region: Methyltransf_31; pfam13847 983545000276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000277 S-adenosylmethionine binding site [chemical binding]; other site 983545000278 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 983545000279 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 983545000280 Methyltransferase small domain; Region: MTS; pfam05175 983545000281 glycogen synthase; Provisional; Region: glgA; PRK00654 983545000282 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 983545000283 ADP-binding pocket [chemical binding]; other site 983545000284 homodimer interface [polypeptide binding]; other site 983545000285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545000286 dimerization interface [polypeptide binding]; other site 983545000287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545000288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545000289 dimer interface [polypeptide binding]; other site 983545000290 phosphorylation site [posttranslational modification] 983545000291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000292 ATP binding site [chemical binding]; other site 983545000293 G-X-G motif; other site 983545000294 two-component response regulator; Provisional; Region: PRK11173 983545000295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000296 active site 983545000297 phosphorylation site [posttranslational modification] 983545000298 intermolecular recognition site; other site 983545000299 dimerization interface [polypeptide binding]; other site 983545000300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545000301 DNA binding site [nucleotide binding] 983545000302 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 983545000303 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 983545000304 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 983545000305 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 983545000306 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 983545000307 DsbD alpha interface [polypeptide binding]; other site 983545000308 catalytic residues [active] 983545000309 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 983545000310 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983545000311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545000312 active site 983545000313 Protein of unknown function, DUF479; Region: DUF479; cl01203 983545000314 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 983545000315 Dehydroquinase class II; Region: DHquinase_II; pfam01220 983545000316 trimer interface [polypeptide binding]; other site 983545000317 active site 983545000318 dimer interface [polypeptide binding]; other site 983545000319 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 983545000320 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545000321 carboxyltransferase (CT) interaction site; other site 983545000322 biotinylation site [posttranslational modification]; other site 983545000323 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 983545000324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545000325 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 983545000326 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 983545000327 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 983545000328 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 983545000329 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 983545000330 DNA methylase; Region: N6_N4_Mtase; cl17433 983545000331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000332 S-adenosylmethionine binding site [chemical binding]; other site 983545000333 Predicted transcriptional regulators [Transcription]; Region: COG1733 983545000334 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 983545000335 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 983545000336 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 983545000337 active site 983545000338 catalytic residues [active] 983545000339 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 983545000340 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 983545000341 active site 983545000342 catalytic residues [active] 983545000343 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 983545000344 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 983545000345 active site 983545000346 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983545000347 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 983545000348 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 983545000349 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 983545000350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545000351 Walker A motif; other site 983545000352 ATP binding site [chemical binding]; other site 983545000353 Walker B motif; other site 983545000354 arginine finger; other site 983545000355 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 983545000356 metal ion-dependent adhesion site (MIDAS); other site 983545000357 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545000358 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545000359 conserved cys residue [active] 983545000360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545000361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545000362 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 983545000363 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545000364 active site 983545000365 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 983545000366 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545000367 active site 983545000368 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545000369 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545000370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545000371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545000372 putative substrate translocation pore; other site 983545000373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545000374 dimerization interface [polypeptide binding]; other site 983545000375 putative DNA binding site [nucleotide binding]; other site 983545000376 putative Zn2+ binding site [ion binding]; other site 983545000377 Predicted permeases [General function prediction only]; Region: COG0701 983545000378 hypothetical protein; Provisional; Region: PRK09897 983545000379 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 983545000380 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 983545000381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545000382 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 983545000383 putative active site [active] 983545000384 putative cosubstrate binding site; other site 983545000385 putative substrate binding site [chemical binding]; other site 983545000386 catalytic site [active] 983545000387 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 983545000388 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 983545000389 active site 983545000390 nucleophile elbow; other site 983545000391 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 983545000392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545000393 catalytic residue [active] 983545000394 Uncharacterized conserved protein [Function unknown]; Region: COG1284 983545000395 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 983545000396 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545000397 putative metal binding site [ion binding]; other site 983545000398 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 983545000399 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 983545000400 GDP-binding site [chemical binding]; other site 983545000401 ACT binding site; other site 983545000402 IMP binding site; other site 983545000403 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 983545000404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545000405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545000406 dimer interface [polypeptide binding]; other site 983545000407 phosphorylation site [posttranslational modification] 983545000408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000409 ATP binding site [chemical binding]; other site 983545000410 Mg2+ binding site [ion binding]; other site 983545000411 G-X-G motif; other site 983545000412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545000413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000414 active site 983545000415 phosphorylation site [posttranslational modification] 983545000416 intermolecular recognition site; other site 983545000417 dimerization interface [polypeptide binding]; other site 983545000418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545000419 DNA binding site [nucleotide binding] 983545000420 Spondin_N; Region: Spond_N; pfam06468 983545000421 Spondin_N; Region: Spond_N; pfam06468 983545000422 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 983545000423 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873 983545000424 metal binding site [ion binding]; metal-binding site 983545000425 phosphoribulokinase; Provisional; Region: PRK15453 983545000426 osmolarity response regulator; Provisional; Region: ompR; PRK09468 983545000427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000428 active site 983545000429 phosphorylation site [posttranslational modification] 983545000430 intermolecular recognition site; other site 983545000431 dimerization interface [polypeptide binding]; other site 983545000432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545000433 DNA binding site [nucleotide binding] 983545000434 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 983545000435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545000436 dimerization interface [polypeptide binding]; other site 983545000437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545000438 dimer interface [polypeptide binding]; other site 983545000439 phosphorylation site [posttranslational modification] 983545000440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000441 ATP binding site [chemical binding]; other site 983545000442 Mg2+ binding site [ion binding]; other site 983545000443 G-X-G motif; other site 983545000444 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 983545000445 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 983545000446 dimerization interface [polypeptide binding]; other site 983545000447 domain crossover interface; other site 983545000448 redox-dependent activation switch; other site 983545000449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545000450 RNA binding surface [nucleotide binding]; other site 983545000451 glucose-1-dehydrogenase; Provisional; Region: PRK06947 983545000452 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545000453 NADP binding site [chemical binding]; other site 983545000454 homodimer interface [polypeptide binding]; other site 983545000455 active site 983545000456 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 983545000457 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983545000458 type II secretion system protein D; Region: type_II_gspD; TIGR02517 983545000459 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000460 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000461 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000462 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 983545000463 type II secretion system protein E; Region: type_II_gspE; TIGR02533 983545000464 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545000465 Walker A motif; other site 983545000466 ATP binding site [chemical binding]; other site 983545000467 Walker B motif; other site 983545000468 type II secretion system protein F; Region: GspF; TIGR02120 983545000469 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 983545000470 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 983545000471 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 983545000472 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 983545000473 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 983545000474 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 983545000475 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 983545000476 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 983545000477 type II secretion system protein I; Region: gspI; TIGR01707 983545000478 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 983545000479 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 983545000480 type II secretion system protein J; Region: gspJ; TIGR01711 983545000481 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 983545000482 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 983545000483 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 983545000484 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 983545000485 GspL periplasmic domain; Region: GspL_C; cl14909 983545000486 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 983545000487 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 983545000488 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 983545000489 AMP binding site [chemical binding]; other site 983545000490 metal binding site [ion binding]; metal-binding site 983545000491 active site 983545000492 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 983545000493 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545000494 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545000495 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 983545000496 active site 983545000497 Zn binding site [ion binding]; other site 983545000498 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 983545000499 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 983545000500 substrate binding site [chemical binding]; other site 983545000501 active site 983545000502 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 983545000503 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 983545000504 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 983545000505 putative NADH binding site [chemical binding]; other site 983545000506 putative active site [active] 983545000507 nudix motif; other site 983545000508 putative metal binding site [ion binding]; other site 983545000509 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 983545000510 metal binding site 2 [ion binding]; metal-binding site 983545000511 putative DNA binding helix; other site 983545000512 metal binding site 1 [ion binding]; metal-binding site 983545000513 dimer interface [polypeptide binding]; other site 983545000514 structural Zn2+ binding site [ion binding]; other site 983545000515 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 983545000516 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 983545000517 Uncharacterized conserved protein [Function unknown]; Region: COG0432 983545000518 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 983545000519 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545000520 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983545000521 ligand binding site [chemical binding]; other site 983545000522 replicative DNA helicase; Region: DnaB; TIGR00665 983545000523 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 983545000524 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 983545000525 Walker A motif; other site 983545000526 ATP binding site [chemical binding]; other site 983545000527 Walker B motif; other site 983545000528 DNA binding loops [nucleotide binding] 983545000529 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 983545000530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545000531 ATP binding site [chemical binding]; other site 983545000532 putative Mg++ binding site [ion binding]; other site 983545000533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545000534 nucleotide binding region [chemical binding]; other site 983545000535 ATP-binding site [chemical binding]; other site 983545000536 CXXC zinc finger domain; Region: zf-CXXC; pfam02008 983545000537 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 983545000538 HRDC domain; Region: HRDC; pfam00570 983545000539 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545000540 CoenzymeA binding site [chemical binding]; other site 983545000541 subunit interaction site [polypeptide binding]; other site 983545000542 PHB binding site; other site 983545000543 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 983545000544 apolar tunnel; other site 983545000545 heme binding site [chemical binding]; other site 983545000546 dimerization interface [polypeptide binding]; other site 983545000547 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 983545000548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545000549 dimerization interface [polypeptide binding]; other site 983545000550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000551 metal binding site [ion binding]; metal-binding site 983545000552 active site 983545000553 I-site; other site 983545000554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000555 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545000556 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000557 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545000558 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000559 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 983545000560 Surface antigen; Region: Bac_surface_Ag; pfam01103 983545000561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 983545000562 Family of unknown function (DUF490); Region: DUF490; pfam04357 983545000563 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 983545000564 MgtE intracellular N domain; Region: MgtE_N; pfam03448 983545000565 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 983545000566 Divalent cation transporter; Region: MgtE; cl00786 983545000567 BON domain; Region: BON; cl02771 983545000568 BON domain; Region: BON; pfam04972 983545000569 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000571 active site 983545000572 phosphorylation site [posttranslational modification] 983545000573 intermolecular recognition site; other site 983545000574 dimerization interface [polypeptide binding]; other site 983545000575 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545000576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000577 metal binding site [ion binding]; metal-binding site 983545000578 active site 983545000579 I-site; other site 983545000580 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 983545000581 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 983545000582 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 983545000583 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 983545000584 Predicted methyltransferase [General function prediction only]; Region: COG4798 983545000585 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 983545000586 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 983545000587 purine monophosphate binding site [chemical binding]; other site 983545000588 dimer interface [polypeptide binding]; other site 983545000589 putative catalytic residues [active] 983545000590 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 983545000591 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 983545000592 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 983545000593 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 983545000594 FMN binding site [chemical binding]; other site 983545000595 active site 983545000596 catalytic residues [active] 983545000597 substrate binding site [chemical binding]; other site 983545000598 Protein of unknown function (DUF962); Region: DUF962; pfam06127 983545000599 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 983545000600 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 983545000601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545000602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545000603 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545000604 putative effector binding pocket; other site 983545000605 dimerization interface [polypeptide binding]; other site 983545000606 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545000607 putative catalytic residues [active] 983545000608 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 983545000609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545000610 motif II; other site 983545000611 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 983545000612 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 983545000613 substrate binding pocket [chemical binding]; other site 983545000614 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 983545000615 Predicted deacylase [General function prediction only]; Region: COG3608 983545000616 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983545000617 active site 983545000618 Zn binding site [ion binding]; other site 983545000619 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545000620 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 983545000621 Conserved TM helix; Region: TM_helix; pfam05552 983545000622 mechanosensitive channel MscS; Provisional; Region: PRK10334 983545000623 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000624 hypothetical protein; Provisional; Region: PRK12361 983545000625 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 983545000626 active site 983545000627 catalytic residues [active] 983545000628 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 983545000629 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545000630 putative catalytic residues [active] 983545000631 Hemerythrin-like domain; Region: Hr-like; cd12108 983545000632 Fe binding site [ion binding]; other site 983545000633 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 983545000634 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 983545000635 Predicted membrane protein [Function unknown]; Region: COG1238 983545000636 Predicted permeases [General function prediction only]; Region: RarD; COG2962 983545000637 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545000638 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000640 active site 983545000641 phosphorylation site [posttranslational modification] 983545000642 intermolecular recognition site; other site 983545000643 dimerization interface [polypeptide binding]; other site 983545000644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545000645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000646 metal binding site [ion binding]; metal-binding site 983545000647 active site 983545000648 I-site; other site 983545000649 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 983545000650 Part of AAA domain; Region: AAA_19; pfam13245 983545000651 Family description; Region: UvrD_C_2; pfam13538 983545000652 Baculoviridae ME53; Region: Baculo_ME53; pfam06061 983545000653 serine acetyltransferase; Provisional; Region: cysE; PRK11132 983545000654 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 983545000655 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 983545000656 trimer interface [polypeptide binding]; other site 983545000657 active site 983545000658 substrate binding site [chemical binding]; other site 983545000659 CoA binding site [chemical binding]; other site 983545000660 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 983545000661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545000662 motif II; other site 983545000663 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 983545000664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545000665 active site 983545000666 DNA binding site [nucleotide binding] 983545000667 Int/Topo IB signature motif; other site 983545000668 Protein of unknown function, DUF484; Region: DUF484; cl17449 983545000669 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 983545000670 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 983545000671 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 983545000672 diaminopimelate decarboxylase; Region: lysA; TIGR01048 983545000673 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 983545000674 active site 983545000675 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545000676 substrate binding site [chemical binding]; other site 983545000677 catalytic residues [active] 983545000678 dimer interface [polypeptide binding]; other site 983545000679 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 983545000680 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 983545000681 active site 983545000682 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 983545000683 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 983545000684 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 983545000685 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 983545000686 flavodoxin FldB; Provisional; Region: PRK12359 983545000687 SnoaL-like domain; Region: SnoaL_2; pfam12680 983545000688 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 983545000689 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545000690 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545000691 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 983545000692 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 983545000693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 983545000694 methionine sulfoxide reductase A; Provisional; Region: PRK14054 983545000695 Protein of unknown function, DUF393; Region: DUF393; pfam04134 983545000696 C factor cell-cell signaling protein; Provisional; Region: PRK09009 983545000697 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545000698 NADP binding site [chemical binding]; other site 983545000699 homodimer interface [polypeptide binding]; other site 983545000700 active site 983545000701 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 983545000702 Na2 binding site [ion binding]; other site 983545000703 putative substrate binding site 1 [chemical binding]; other site 983545000704 Na binding site 1 [ion binding]; other site 983545000705 putative substrate binding site 2 [chemical binding]; other site 983545000706 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545000707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000708 NAD(P) binding site [chemical binding]; other site 983545000709 active site 983545000710 hypothetical protein; Provisional; Region: PRK10626 983545000711 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 983545000712 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545000713 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000714 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983545000715 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 983545000716 putative acyl-acceptor binding pocket; other site 983545000717 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983545000718 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 983545000719 putative acyl-acceptor binding pocket; other site 983545000720 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 983545000721 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 983545000722 active site 983545000723 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 983545000724 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 983545000725 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983545000726 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 983545000727 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 983545000728 FMN binding site [chemical binding]; other site 983545000729 active site 983545000730 catalytic residues [active] 983545000731 substrate binding site [chemical binding]; other site 983545000732 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 983545000733 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 983545000734 trimer interface [polypeptide binding]; other site 983545000735 active site 983545000736 substrate binding site [chemical binding]; other site 983545000737 CoA binding site [chemical binding]; other site 983545000738 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 983545000739 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 983545000740 acyl-activating enzyme (AAE) consensus motif; other site 983545000741 AMP binding site [chemical binding]; other site 983545000742 active site 983545000743 CoA binding site [chemical binding]; other site 983545000744 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545000745 classical (c) SDRs; Region: SDR_c; cd05233 983545000746 NAD(P) binding site [chemical binding]; other site 983545000747 active site 983545000748 phage shock protein A; Region: phageshock_pspA; TIGR02977 983545000749 Protein of unknown function (DUF461); Region: DUF461; pfam04314 983545000750 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 983545000751 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 983545000752 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 983545000753 Flavodoxin; Region: Flavodoxin_1; pfam00258 983545000754 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 983545000755 FAD binding pocket [chemical binding]; other site 983545000756 FAD binding motif [chemical binding]; other site 983545000757 catalytic residues [active] 983545000758 NAD binding pocket [chemical binding]; other site 983545000759 phosphate binding motif [ion binding]; other site 983545000760 beta-alpha-beta structure motif; other site 983545000761 sulfite reductase subunit beta; Provisional; Region: PRK13504 983545000762 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545000763 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545000764 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 983545000765 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983545000766 Active Sites [active] 983545000767 TIGR03899 family protein; Region: TIGR03899 983545000768 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 983545000770 active site 983545000771 phosphorylation site [posttranslational modification] 983545000772 intermolecular recognition site; other site 983545000773 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 983545000774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545000775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000776 metal binding site [ion binding]; metal-binding site 983545000777 active site 983545000778 I-site; other site 983545000779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000780 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 983545000781 putative uracil binding site [chemical binding]; other site 983545000782 putative active site [active] 983545000783 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 983545000784 Fatty acid desaturase; Region: FA_desaturase; pfam00487 983545000785 Di-iron ligands [ion binding]; other site 983545000786 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 983545000787 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 983545000788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545000789 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 983545000790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000791 S-adenosylmethionine binding site [chemical binding]; other site 983545000792 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545000793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545000794 active site 983545000795 phosphorylation site [posttranslational modification] 983545000796 intermolecular recognition site; other site 983545000797 dimerization interface [polypeptide binding]; other site 983545000798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545000799 DNA binding residues [nucleotide binding] 983545000800 dimerization interface [polypeptide binding]; other site 983545000801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000802 S-adenosylmethionine binding site [chemical binding]; other site 983545000803 Methyltransferase domain; Region: Methyltransf_23; pfam13489 983545000804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545000805 S-adenosylmethionine binding site [chemical binding]; other site 983545000806 alanine racemase; Reviewed; Region: alr; PRK00053 983545000807 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 983545000808 active site 983545000809 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545000810 substrate binding site [chemical binding]; other site 983545000811 catalytic residues [active] 983545000812 dimer interface [polypeptide binding]; other site 983545000813 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 983545000814 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 983545000815 homodimer interface [polypeptide binding]; other site 983545000816 substrate-cofactor binding pocket; other site 983545000817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000818 catalytic residue [active] 983545000819 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 983545000820 S1 domain; Region: S1_2; pfam13509 983545000821 S1 domain; Region: S1_2; pfam13509 983545000822 OsmC-like protein; Region: OsmC; cl00767 983545000823 hypothetical protein; Provisional; Region: PRK05939 983545000824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545000825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545000826 catalytic residue [active] 983545000827 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 983545000828 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983545000829 putative acyl-acceptor binding pocket; other site 983545000830 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 983545000831 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 983545000832 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 983545000833 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 983545000834 phosphopeptide binding site; other site 983545000835 NRDE protein; Region: NRDE; pfam05742 983545000836 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 983545000837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545000838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000839 homodimer interface [polypeptide binding]; other site 983545000840 catalytic residue [active] 983545000841 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 983545000842 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 983545000843 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 983545000844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545000845 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 983545000846 dimerization interface [polypeptide binding]; other site 983545000847 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 983545000848 active site clefts [active] 983545000849 zinc binding site [ion binding]; other site 983545000850 dimer interface [polypeptide binding]; other site 983545000851 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 983545000852 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545000853 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983545000854 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545000855 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983545000856 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 983545000857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545000858 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 983545000859 putative ADP-binding pocket [chemical binding]; other site 983545000860 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 983545000861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545000862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545000863 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545000864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545000865 Bacterial sugar transferase; Region: Bac_transf; pfam02397 983545000866 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 983545000867 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 983545000868 putative trimer interface [polypeptide binding]; other site 983545000869 putative CoA binding site [chemical binding]; other site 983545000870 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983545000871 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545000872 inhibitor-cofactor binding pocket; inhibition site 983545000873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000874 catalytic residue [active] 983545000875 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 983545000876 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545000877 NAD(P) binding site [chemical binding]; other site 983545000878 homodimer interface [polypeptide binding]; other site 983545000879 substrate binding site [chemical binding]; other site 983545000880 active site 983545000881 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545000882 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545000883 SLBB domain; Region: SLBB; pfam10531 983545000884 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 983545000885 Chain length determinant protein; Region: Wzz; pfam02706 983545000886 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 983545000887 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 983545000888 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 983545000889 FAD binding domain; Region: FAD_binding_4; pfam01565 983545000890 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 983545000891 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545000892 dimerization interface [polypeptide binding]; other site 983545000893 putative DNA binding site [nucleotide binding]; other site 983545000894 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 983545000895 putative Zn2+ binding site [ion binding]; other site 983545000896 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 983545000897 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 983545000898 Type III pantothenate kinase; Region: Pan_kinase; cl17198 983545000899 elongation factor Tu; Reviewed; Region: PRK00049 983545000900 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 983545000901 G1 box; other site 983545000902 GEF interaction site [polypeptide binding]; other site 983545000903 GTP/Mg2+ binding site [chemical binding]; other site 983545000904 Switch I region; other site 983545000905 G2 box; other site 983545000906 G3 box; other site 983545000907 Switch II region; other site 983545000908 G4 box; other site 983545000909 G5 box; other site 983545000910 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 983545000911 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 983545000912 Antibiotic Binding Site [chemical binding]; other site 983545000913 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545000914 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545000915 substrate binding pocket [chemical binding]; other site 983545000916 membrane-bound complex binding site; other site 983545000917 hinge residues; other site 983545000918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545000919 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545000920 active site 983545000921 catalytic tetrad [active] 983545000922 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 983545000923 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545000924 FAD binding site [chemical binding]; other site 983545000925 substrate binding pocket [chemical binding]; other site 983545000926 catalytic base [active] 983545000927 PAS domain; Region: PAS_9; pfam13426 983545000928 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545000929 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000930 metal binding site [ion binding]; metal-binding site 983545000931 active site 983545000932 I-site; other site 983545000933 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000934 Ras-like protein; Provisional; Region: PTZ00369 983545000935 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 983545000936 Rab subfamily motif 1 (RabSF1); other site 983545000937 G1 box; other site 983545000938 GTP/Mg2+ binding site [chemical binding]; other site 983545000939 Rab subfamily motif 2 (RabSF2); other site 983545000940 Switch I region; other site 983545000941 G2 box; other site 983545000942 effector interaction site; other site 983545000943 GDI interaction site; other site 983545000944 Rab family motif 1 (RabF1); other site 983545000945 GEF interaction site [polypeptide binding]; other site 983545000946 Rab family motif 2 (RabF2); other site 983545000947 G3 box; other site 983545000948 Switch II region; other site 983545000949 Rab family motif 3 (RabF3); other site 983545000950 Rab family motif 4 (RabF4); other site 983545000951 Rab family motif 5 (RabF5); other site 983545000952 Rab subfamily motif 3 (RabSF3); other site 983545000953 G4 box; other site 983545000954 G5 box; other site 983545000955 Rab subfamily motif 4 (RabSF4); other site 983545000956 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545000957 ligand binding site [chemical binding]; other site 983545000958 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 983545000959 AbgT putative transporter family; Region: ABG_transport; pfam03806 983545000960 ferrochelatase; Reviewed; Region: hemH; PRK00035 983545000961 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 983545000962 C-terminal domain interface [polypeptide binding]; other site 983545000963 active site 983545000964 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 983545000965 active site 983545000966 N-terminal domain interface [polypeptide binding]; other site 983545000967 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 983545000968 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 983545000969 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 983545000970 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545000971 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 983545000972 putative C-terminal domain interface [polypeptide binding]; other site 983545000973 putative GSH binding site (G-site) [chemical binding]; other site 983545000974 putative dimer interface [polypeptide binding]; other site 983545000975 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545000976 N-terminal domain interface [polypeptide binding]; other site 983545000977 dimer interface [polypeptide binding]; other site 983545000978 substrate binding pocket (H-site) [chemical binding]; other site 983545000979 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 983545000980 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545000981 C-terminal domain interface [polypeptide binding]; other site 983545000982 GSH binding site (G-site) [chemical binding]; other site 983545000983 dimer interface [polypeptide binding]; other site 983545000984 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545000985 N-terminal domain interface [polypeptide binding]; other site 983545000986 dimer interface [polypeptide binding]; other site 983545000987 substrate binding pocket (H-site) [chemical binding]; other site 983545000988 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 983545000989 FtsH protease regulator HflC; Provisional; Region: PRK11029 983545000990 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 983545000991 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 983545000992 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 983545000993 HflK protein; Region: hflK; TIGR01933 983545000994 GTPase HflX; Provisional; Region: PRK11058 983545000995 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 983545000996 HflX GTPase family; Region: HflX; cd01878 983545000997 G1 box; other site 983545000998 GTP/Mg2+ binding site [chemical binding]; other site 983545000999 Switch I region; other site 983545001000 G2 box; other site 983545001001 G3 box; other site 983545001002 Switch II region; other site 983545001003 G4 box; other site 983545001004 G5 box; other site 983545001005 bacterial Hfq-like; Region: Hfq; cd01716 983545001006 hexamer interface [polypeptide binding]; other site 983545001007 Sm1 motif; other site 983545001008 RNA binding site [nucleotide binding]; other site 983545001009 Sm2 motif; other site 983545001010 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 983545001011 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 983545001012 active site 983545001013 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 983545001014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001015 ATP binding site [chemical binding]; other site 983545001016 Mg2+ binding site [ion binding]; other site 983545001017 G-X-G motif; other site 983545001018 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 983545001019 ATP binding site [chemical binding]; other site 983545001020 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 983545001021 AMIN domain; Region: AMIN; pfam11741 983545001022 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 983545001023 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 983545001024 active site 983545001025 metal binding site [ion binding]; metal-binding site 983545001026 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545001027 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983545001028 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 983545001029 putative carbohydrate kinase; Provisional; Region: PRK10565 983545001030 Uncharacterized conserved protein [Function unknown]; Region: COG0062 983545001031 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 983545001032 putative substrate binding site [chemical binding]; other site 983545001033 putative ATP binding site [chemical binding]; other site 983545001034 epoxyqueuosine reductase; Region: TIGR00276 983545001035 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 983545001036 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 983545001037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545001038 S-adenosylmethionine binding site [chemical binding]; other site 983545001039 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 983545001040 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 983545001041 NAD binding site [chemical binding]; other site 983545001042 active site 983545001043 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 983545001044 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545001045 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545001046 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 983545001047 pentamer interface [polypeptide binding]; other site 983545001048 dodecaamer interface [polypeptide binding]; other site 983545001049 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 983545001050 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 983545001051 tetramer interface [polypeptide binding]; other site 983545001052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545001053 catalytic residue [active] 983545001054 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 983545001055 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 983545001056 putative active site; other site 983545001057 catalytic triad [active] 983545001058 putative dimer interface [polypeptide binding]; other site 983545001059 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 983545001060 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 983545001061 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 983545001062 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545001063 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 983545001064 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 983545001065 dimerization interface [polypeptide binding]; other site 983545001066 active site 983545001067 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545001068 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545001069 PAS domain S-box; Region: sensory_box; TIGR00229 983545001070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545001071 putative active site [active] 983545001072 heme pocket [chemical binding]; other site 983545001073 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545001074 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001075 metal binding site [ion binding]; metal-binding site 983545001076 active site 983545001077 I-site; other site 983545001078 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545001079 Uncharacterized conserved protein [Function unknown]; Region: COG0397 983545001080 hypothetical protein; Validated; Region: PRK00029 983545001081 Cytochrome c553 [Energy production and conversion]; Region: COG2863 983545001082 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545001083 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 983545001084 putative C-terminal domain interface [polypeptide binding]; other site 983545001085 putative GSH binding site (G-site) [chemical binding]; other site 983545001086 putative dimer interface [polypeptide binding]; other site 983545001087 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 983545001088 putative N-terminal domain interface [polypeptide binding]; other site 983545001089 putative dimer interface [polypeptide binding]; other site 983545001090 putative substrate binding pocket (H-site) [chemical binding]; other site 983545001091 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 983545001092 dimerization interface [polypeptide binding]; other site 983545001093 DNA binding site [nucleotide binding] 983545001094 corepressor binding sites; other site 983545001095 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 983545001096 FAD binding site [chemical binding]; other site 983545001097 hypothetical protein; Reviewed; Region: PRK01637 983545001098 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 983545001099 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 983545001100 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 983545001101 putative active site [active] 983545001102 dimerization interface [polypeptide binding]; other site 983545001103 putative tRNAtyr binding site [nucleotide binding]; other site 983545001104 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 983545001105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545001106 Coenzyme A binding pocket [chemical binding]; other site 983545001107 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 983545001108 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 983545001109 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545001110 Int/Topo IB signature motif; other site 983545001111 DNA binding site [nucleotide binding] 983545001112 active site 983545001113 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 983545001114 active site 983545001115 catalytic residues [active] 983545001116 Int/Topo IB signature motif; other site 983545001117 DNA binding site [nucleotide binding] 983545001118 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 983545001119 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 983545001120 acyl-activating enzyme (AAE) consensus motif; other site 983545001121 putative AMP binding site [chemical binding]; other site 983545001122 putative active site [active] 983545001123 putative CoA binding site [chemical binding]; other site 983545001124 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 983545001125 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 983545001126 [2Fe-2S] cluster binding site [ion binding]; other site 983545001127 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 983545001128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545001129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545001130 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 983545001131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983545001132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545001133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545001134 Cytochrome P450; Region: p450; cl12078 983545001135 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 983545001136 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983545001137 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 983545001138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001139 putative substrate translocation pore; other site 983545001140 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545001141 Cytochrome P450; Region: p450; cl12078 983545001142 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 983545001143 Amidohydrolase; Region: Amidohydro_2; pfam04909 983545001144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545001145 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001146 active site 983545001147 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545001148 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001149 active site 983545001150 enoyl-CoA hydratase; Provisional; Region: PRK09245 983545001151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545001152 substrate binding site [chemical binding]; other site 983545001153 oxyanion hole (OAH) forming residues; other site 983545001154 trimer interface [polypeptide binding]; other site 983545001155 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545001156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001157 active site 983545001158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545001159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545001160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545001161 dimerization interface [polypeptide binding]; other site 983545001162 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 983545001163 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 983545001164 dimer interface [polypeptide binding]; other site 983545001165 PYR/PP interface [polypeptide binding]; other site 983545001166 TPP binding site [chemical binding]; other site 983545001167 substrate binding site [chemical binding]; other site 983545001168 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 983545001169 TPP-binding site [chemical binding]; other site 983545001170 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 983545001171 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545001172 Ligand binding site [chemical binding]; other site 983545001173 Electron transfer flavoprotein domain; Region: ETF; pfam01012 983545001174 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545001175 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545001176 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983545001177 Transmembrane secretion effector; Region: MFS_3; pfam05977 983545001178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001179 putative substrate translocation pore; other site 983545001180 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545001181 Ligand Binding Site [chemical binding]; other site 983545001182 Hemerythrin-like domain; Region: Hr-like; cd12108 983545001183 Fe binding site [ion binding]; other site 983545001184 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 983545001185 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 983545001186 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545001187 active site 983545001188 metal binding site [ion binding]; metal-binding site 983545001189 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545001190 classical (c) SDRs; Region: SDR_c; cd05233 983545001191 NAD(P) binding site [chemical binding]; other site 983545001192 active site 983545001193 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 983545001194 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545001195 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 983545001196 Bacterial transcriptional regulator; Region: IclR; pfam01614 983545001197 lipid-transfer protein; Provisional; Region: PRK07855 983545001198 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 983545001199 active site 983545001200 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 983545001201 DUF35 OB-fold domain; Region: DUF35; pfam01796 983545001202 short chain dehydrogenase; Provisional; Region: PRK12828 983545001203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001204 NAD(P) binding site [chemical binding]; other site 983545001205 active site 983545001206 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 983545001207 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 983545001208 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 983545001209 iron-sulfur cluster [ion binding]; other site 983545001210 [2Fe-2S] cluster binding site [ion binding]; other site 983545001211 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 983545001212 beta subunit interface [polypeptide binding]; other site 983545001213 alpha subunit interface [polypeptide binding]; other site 983545001214 active site 983545001215 substrate binding site [chemical binding]; other site 983545001216 Fe binding site [ion binding]; other site 983545001217 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 983545001218 inter-subunit interface; other site 983545001219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001220 putative substrate translocation pore; other site 983545001221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545001222 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 983545001223 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545001224 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 983545001225 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 983545001226 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545001227 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 983545001228 short chain dehydrogenase; Provisional; Region: PRK07478 983545001229 classical (c) SDRs; Region: SDR_c; cd05233 983545001230 NAD(P) binding site [chemical binding]; other site 983545001231 active site 983545001232 Amidohydrolase; Region: Amidohydro_2; pfam04909 983545001233 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 983545001234 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 983545001235 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 983545001236 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983545001237 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545001238 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545001239 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 983545001240 dimer interface [polypeptide binding]; other site 983545001241 active site 983545001242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545001243 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 983545001244 putative NAD(P) binding site [chemical binding]; other site 983545001245 putative active site [active] 983545001246 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 983545001247 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545001248 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 983545001249 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545001250 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545001251 active site 983545001252 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545001253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545001254 substrate binding site [chemical binding]; other site 983545001255 oxyanion hole (OAH) forming residues; other site 983545001256 trimer interface [polypeptide binding]; other site 983545001257 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 983545001258 classical (c) SDRs; Region: SDR_c; cd05233 983545001259 NAD(P) binding site [chemical binding]; other site 983545001260 active site 983545001261 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545001262 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 983545001263 NAD(P) binding site [chemical binding]; other site 983545001264 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 983545001265 homodecamer interface [polypeptide binding]; other site 983545001266 GTP cyclohydrolase I; Provisional; Region: PLN03044 983545001267 active site 983545001268 putative catalytic site residues [active] 983545001269 zinc binding site [ion binding]; other site 983545001270 GTP-CH-I/GFRP interaction surface; other site 983545001271 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 983545001272 putative active site [active] 983545001273 putative metal binding residues [ion binding]; other site 983545001274 signature motif; other site 983545001275 putative triphosphate binding site [ion binding]; other site 983545001276 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 983545001277 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 983545001278 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 983545001279 putative active site [active] 983545001280 putative NTP binding site [chemical binding]; other site 983545001281 putative nucleic acid binding site [nucleotide binding]; other site 983545001282 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 983545001283 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 983545001284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983545001285 Transposase; Region: HTH_Tnp_1; pfam01527 983545001286 putative transposase OrfB; Reviewed; Region: PHA02517 983545001287 HTH-like domain; Region: HTH_21; pfam13276 983545001288 Integrase core domain; Region: rve; pfam00665 983545001289 Integrase core domain; Region: rve_3; pfam13683 983545001290 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 983545001291 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 983545001292 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 983545001293 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 983545001294 generic binding surface I; other site 983545001295 generic binding surface II; other site 983545001296 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 983545001297 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 983545001298 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545001299 active site 983545001300 DNA binding site [nucleotide binding] 983545001301 Int/Topo IB signature motif; other site 983545001302 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 983545001303 non-specific DNA binding site [nucleotide binding]; other site 983545001304 salt bridge; other site 983545001305 sequence-specific DNA binding site [nucleotide binding]; other site 983545001306 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 983545001307 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 983545001308 dimerization interface [polypeptide binding]; other site 983545001309 putative active cleft [active] 983545001310 alpha-glucosidase; Provisional; Region: PRK10137 983545001311 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 983545001312 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545001313 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545001314 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 983545001315 Na binding site [ion binding]; other site 983545001316 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 983545001317 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 983545001318 MOFRL family; Region: MOFRL; pfam05161 983545001319 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001320 MarR family; Region: MarR_2; pfam12802 983545001321 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 983545001322 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 983545001323 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 983545001324 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 983545001325 HemY protein N-terminus; Region: HemY_N; pfam07219 983545001326 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 983545001327 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 983545001328 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 983545001329 active site 983545001330 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 983545001331 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 983545001332 domain interfaces; other site 983545001333 active site 983545001334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545001335 Coenzyme A binding pocket [chemical binding]; other site 983545001336 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 983545001337 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 983545001338 putative hydrolase; Provisional; Region: PRK11460 983545001339 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 983545001340 putative iron binding site [ion binding]; other site 983545001341 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 983545001342 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 983545001343 catalytic site [active] 983545001344 G-X2-G-X-G-K; other site 983545001345 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 983545001346 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 983545001347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545001348 Zn2+ binding site [ion binding]; other site 983545001349 Mg2+ binding site [ion binding]; other site 983545001350 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 983545001351 synthetase active site [active] 983545001352 NTP binding site [chemical binding]; other site 983545001353 metal binding site [ion binding]; metal-binding site 983545001354 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 983545001355 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 983545001356 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 983545001357 homotrimer interaction site [polypeptide binding]; other site 983545001358 putative active site [active] 983545001359 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 983545001360 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 983545001361 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 983545001362 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545001363 putative catalytic residues [active] 983545001364 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 983545001365 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 983545001366 ssDNA binding site; other site 983545001367 generic binding surface II; other site 983545001368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545001369 ATP binding site [chemical binding]; other site 983545001370 putative Mg++ binding site [ion binding]; other site 983545001371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001372 nucleotide binding region [chemical binding]; other site 983545001373 ATP-binding site [chemical binding]; other site 983545001374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545001375 S-adenosylmethionine binding site [chemical binding]; other site 983545001376 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 983545001377 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545001378 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 983545001379 catalytic triad [active] 983545001380 dimer interface [polypeptide binding]; other site 983545001381 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 983545001382 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 983545001383 Walker A/P-loop; other site 983545001384 ATP binding site [chemical binding]; other site 983545001385 Q-loop/lid; other site 983545001386 ABC transporter signature motif; other site 983545001387 Walker B; other site 983545001388 D-loop; other site 983545001389 H-loop/switch region; other site 983545001390 ABC-2 type transporter; Region: ABC2_membrane; cl17235 983545001391 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 983545001392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983545001393 Histidine kinase; Region: HisKA_3; pfam07730 983545001394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001395 ATP binding site [chemical binding]; other site 983545001396 Mg2+ binding site [ion binding]; other site 983545001397 G-X-G motif; other site 983545001398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545001399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001400 active site 983545001401 phosphorylation site [posttranslational modification] 983545001402 intermolecular recognition site; other site 983545001403 dimerization interface [polypeptide binding]; other site 983545001404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545001405 DNA binding residues [nucleotide binding] 983545001406 dimerization interface [polypeptide binding]; other site 983545001407 heat shock protein HtpX; Provisional; Region: PRK05457 983545001408 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 983545001409 Predicted flavoproteins [General function prediction only]; Region: COG2081 983545001410 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545001411 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 983545001412 active site 983545001413 catalytic site [active] 983545001414 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545001415 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 983545001416 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 983545001417 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 983545001418 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 983545001419 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 983545001420 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 983545001421 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 983545001422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545001423 Walker A/P-loop; other site 983545001424 ATP binding site [chemical binding]; other site 983545001425 Q-loop/lid; other site 983545001426 ABC transporter signature motif; other site 983545001427 Walker B; other site 983545001428 D-loop; other site 983545001429 H-loop/switch region; other site 983545001430 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 983545001431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545001432 dimer interface [polypeptide binding]; other site 983545001433 conserved gate region; other site 983545001434 putative PBP binding loops; other site 983545001435 ABC-ATPase subunit interface; other site 983545001436 hypothetical protein; Provisional; Region: PRK11622 983545001437 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 983545001438 Protein of unknown function, DUF547; Region: DUF547; pfam04784 983545001439 Uncharacterized conserved protein [Function unknown]; Region: COG0398 983545001440 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 983545001441 mercuric reductase; Validated; Region: PRK06370 983545001442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545001443 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545001444 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545001445 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545001446 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545001447 sugar efflux transporter; Region: 2A0120; TIGR00899 983545001448 PAS domain S-box; Region: sensory_box; TIGR00229 983545001449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545001450 putative active site [active] 983545001451 heme pocket [chemical binding]; other site 983545001452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545001453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001454 metal binding site [ion binding]; metal-binding site 983545001455 active site 983545001456 I-site; other site 983545001457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545001458 DNA binding site [nucleotide binding] 983545001459 AAA ATPase domain; Region: AAA_16; pfam13191 983545001460 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545001461 Protein export membrane protein; Region: SecD_SecF; cl14618 983545001462 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545001463 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545001464 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545001465 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545001466 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 983545001467 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545001468 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545001469 Peptidase family M28; Region: Peptidase_M28; pfam04389 983545001470 metal binding site [ion binding]; metal-binding site 983545001471 DsrE/DsrF-like family; Region: DrsE; pfam02635 983545001472 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 983545001473 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 983545001474 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983545001475 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001476 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 983545001477 AsnC family; Region: AsnC_trans_reg; pfam01037 983545001478 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 983545001479 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545001480 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983545001481 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545001482 catalytic residue [active] 983545001483 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 983545001484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545001485 active site 983545001486 motif I; other site 983545001487 motif II; other site 983545001488 ferredoxin-NADP reductase; Provisional; Region: PRK10926 983545001489 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 983545001490 FAD binding pocket [chemical binding]; other site 983545001491 FAD binding motif [chemical binding]; other site 983545001492 phosphate binding motif [ion binding]; other site 983545001493 beta-alpha-beta structure motif; other site 983545001494 NAD binding pocket [chemical binding]; other site 983545001495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545001496 S-adenosylmethionine binding site [chemical binding]; other site 983545001497 siroheme synthase; Provisional; Region: cysG; PRK10637 983545001498 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 983545001499 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 983545001500 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 983545001501 active site 983545001502 SAM binding site [chemical binding]; other site 983545001503 homodimer interface [polypeptide binding]; other site 983545001504 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 983545001505 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545001506 ATP binding site [chemical binding]; other site 983545001507 Mg++ binding site [ion binding]; other site 983545001508 motif III; other site 983545001509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001510 nucleotide binding region [chemical binding]; other site 983545001511 ATP-binding site [chemical binding]; other site 983545001512 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 983545001513 putative RNA binding site [nucleotide binding]; other site 983545001514 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545001515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001516 binding surface 983545001517 TPR motif; other site 983545001518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001519 TPR motif; other site 983545001520 binding surface 983545001521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001522 TPR motif; other site 983545001523 binding surface 983545001524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001525 TPR motif; other site 983545001526 binding surface 983545001527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001528 TPR motif; other site 983545001529 binding surface 983545001530 thioredoxin 2; Provisional; Region: PRK10996 983545001531 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 983545001532 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545001533 catalytic residues [active] 983545001534 Ion transport protein; Region: Ion_trans; pfam00520 983545001535 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 983545001536 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 983545001537 putative active site [active] 983545001538 metal binding site [ion binding]; metal-binding site 983545001539 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545001540 active site 983545001541 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 983545001542 tetramerization interface [polypeptide binding]; other site 983545001543 substrate binding pocket [chemical binding]; other site 983545001544 catalytic residues [active] 983545001545 inhibitor binding sites; inhibition site 983545001546 NADP(H) binding site [chemical binding]; other site 983545001547 Ferredoxin [Energy production and conversion]; Region: COG1146 983545001548 4Fe-4S binding domain; Region: Fer4; cl02805 983545001549 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 983545001550 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 983545001551 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 983545001552 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 983545001553 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 983545001554 dimer interface [polypeptide binding]; other site 983545001555 ADP-ribose binding site [chemical binding]; other site 983545001556 active site 983545001557 nudix motif; other site 983545001558 metal binding site [ion binding]; metal-binding site 983545001559 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 983545001560 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 983545001561 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545001562 active site 983545001563 metal binding site [ion binding]; metal-binding site 983545001564 hexamer interface [polypeptide binding]; other site 983545001565 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545001566 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 983545001567 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 983545001568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001569 ATP binding site [chemical binding]; other site 983545001570 Mg2+ binding site [ion binding]; other site 983545001571 G-X-G motif; other site 983545001572 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 983545001573 anchoring element; other site 983545001574 dimer interface [polypeptide binding]; other site 983545001575 ATP binding site [chemical binding]; other site 983545001576 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 983545001577 active site 983545001578 metal binding site [ion binding]; metal-binding site 983545001579 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 983545001580 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043 983545001581 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 983545001582 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 983545001583 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545001584 FeS/SAM binding site; other site 983545001585 elongation factor P; Validated; Region: PRK00529 983545001586 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 983545001587 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 983545001588 RNA binding site [nucleotide binding]; other site 983545001589 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 983545001590 RNA binding site [nucleotide binding]; other site 983545001591 poxB regulator PoxA; Provisional; Region: PRK09350 983545001592 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983545001593 motif 1; other site 983545001594 dimer interface [polypeptide binding]; other site 983545001595 active site 983545001596 motif 2; other site 983545001597 motif 3; other site 983545001598 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545001599 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001600 metal binding site [ion binding]; metal-binding site 983545001601 active site 983545001602 I-site; other site 983545001603 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545001604 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 983545001605 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 983545001606 active site 983545001607 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 983545001608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545001609 S-adenosylmethionine binding site [chemical binding]; other site 983545001610 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 983545001611 BolA-like protein; Region: BolA; cl00386 983545001612 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 983545001613 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 983545001614 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 983545001615 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 983545001616 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 983545001617 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 983545001618 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545001619 E3 interaction surface; other site 983545001620 lipoyl attachment site [posttranslational modification]; other site 983545001621 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 983545001622 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 983545001623 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 983545001624 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 983545001625 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 983545001626 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 983545001627 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 983545001628 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545001629 catalytic loop [active] 983545001630 iron binding site [ion binding]; other site 983545001631 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 983545001632 FAD binding pocket [chemical binding]; other site 983545001633 FAD binding motif [chemical binding]; other site 983545001634 phosphate binding motif [ion binding]; other site 983545001635 beta-alpha-beta structure motif; other site 983545001636 NAD binding pocket [chemical binding]; other site 983545001637 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 983545001638 ApbE family; Region: ApbE; pfam02424 983545001639 Protein of unknown function (DUF539); Region: DUF539; cl01129 983545001640 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 983545001641 active site 983545001642 DNA polymerase IV; Validated; Region: PRK02406 983545001643 DNA binding site [nucleotide binding] 983545001644 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 983545001645 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 983545001646 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 983545001647 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 983545001648 active site 983545001649 elongation factor G; Reviewed; Region: PRK00007 983545001650 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 983545001651 G1 box; other site 983545001652 putative GEF interaction site [polypeptide binding]; other site 983545001653 GTP/Mg2+ binding site [chemical binding]; other site 983545001654 Switch I region; other site 983545001655 G2 box; other site 983545001656 G3 box; other site 983545001657 Switch II region; other site 983545001658 G4 box; other site 983545001659 G5 box; other site 983545001660 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 983545001661 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 983545001662 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 983545001663 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545001664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001665 metal binding site [ion binding]; metal-binding site 983545001666 active site 983545001667 I-site; other site 983545001668 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545001669 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545001670 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 983545001671 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545001672 Amidohydrolase; Region: Amidohydro_4; pfam13147 983545001673 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 983545001674 active site 983545001675 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545001676 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545001677 GAF domain; Region: GAF; pfam01590 983545001678 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 983545001679 type II secretion system protein E; Region: type_II_gspE; TIGR02533 983545001680 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545001681 Walker A motif; other site 983545001682 ATP binding site [chemical binding]; other site 983545001683 Walker B motif; other site 983545001684 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 983545001685 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 983545001686 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 983545001687 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 983545001688 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 983545001689 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 983545001690 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 983545001691 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 983545001692 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 983545001693 putative translocon binding site; other site 983545001694 protein-rRNA interface [nucleotide binding]; other site 983545001695 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 983545001696 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 983545001697 G-X-X-G motif; other site 983545001698 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 983545001699 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 983545001700 23S rRNA interface [nucleotide binding]; other site 983545001701 5S rRNA interface [nucleotide binding]; other site 983545001702 putative antibiotic binding site [chemical binding]; other site 983545001703 L25 interface [polypeptide binding]; other site 983545001704 L27 interface [polypeptide binding]; other site 983545001705 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 983545001706 23S rRNA interface [nucleotide binding]; other site 983545001707 putative translocon interaction site; other site 983545001708 signal recognition particle (SRP54) interaction site; other site 983545001709 L23 interface [polypeptide binding]; other site 983545001710 trigger factor interaction site; other site 983545001711 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 983545001712 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 983545001713 protein binding site [polypeptide binding]; other site 983545001714 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 983545001715 Active site serine [active] 983545001716 conserved repeat domain; Region: B_ant_repeat; TIGR01451 983545001717 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 983545001718 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545001719 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001720 metal binding site [ion binding]; metal-binding site 983545001721 active site 983545001722 I-site; other site 983545001723 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545001724 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 983545001725 tetramer interface [polypeptide binding]; other site 983545001726 heme binding pocket [chemical binding]; other site 983545001727 NADPH binding site [chemical binding]; other site 983545001728 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545001729 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 983545001730 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 983545001731 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 983545001732 putative active site [active] 983545001733 putative substrate binding site [chemical binding]; other site 983545001734 putative cosubstrate binding site; other site 983545001735 catalytic site [active] 983545001736 2'-5' RNA ligase; Provisional; Region: PRK15124 983545001737 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 983545001738 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 983545001739 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545001740 ATP binding site [chemical binding]; other site 983545001741 putative Mg++ binding site [ion binding]; other site 983545001742 helicase superfamily c-terminal domain; Region: HELICc; smart00490 983545001743 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 983545001744 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 983545001745 Transglycosylase; Region: Transgly; pfam00912 983545001746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 983545001747 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 983545001748 Nitrogen regulatory protein P-II; Region: P-II; smart00938 983545001749 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 983545001750 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545001751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001752 active site 983545001753 phosphorylation site [posttranslational modification] 983545001754 intermolecular recognition site; other site 983545001755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545001756 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545001757 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545001758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545001759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001760 ATP binding site [chemical binding]; other site 983545001761 Mg2+ binding site [ion binding]; other site 983545001762 G-X-G motif; other site 983545001763 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 983545001764 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 983545001765 cyclase homology domain; Region: CHD; cd07302 983545001766 nucleotidyl binding site; other site 983545001767 metal binding site [ion binding]; metal-binding site 983545001768 dimer interface [polypeptide binding]; other site 983545001769 Tetratricopeptide repeat; Region: TPR_2; pfam07719 983545001770 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 983545001771 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983545001772 inhibitor-cofactor binding pocket; inhibition site 983545001773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545001774 catalytic residue [active] 983545001775 aspartate carbamoyltransferase; Provisional; Region: PRK08192 983545001776 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 983545001777 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 983545001778 AAA domain; Region: AAA_17; pfam13207 983545001779 AAA domain; Region: AAA_18; pfam13238 983545001780 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 983545001781 active site 983545001782 catalytic triad [active] 983545001783 oxyanion hole [active] 983545001784 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 983545001785 active site 983545001786 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545001788 putative DNA binding site [nucleotide binding]; other site 983545001789 putative Zn2+ binding site [ion binding]; other site 983545001790 AsnC family; Region: AsnC_trans_reg; pfam01037 983545001791 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 983545001792 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983545001793 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 983545001794 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 983545001795 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 983545001796 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545001797 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545001798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545001799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545001800 dimer interface [polypeptide binding]; other site 983545001801 phosphorylation site [posttranslational modification] 983545001802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001803 ATP binding site [chemical binding]; other site 983545001804 Mg2+ binding site [ion binding]; other site 983545001805 G-X-G motif; other site 983545001806 Response regulator receiver domain; Region: Response_reg; pfam00072 983545001807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001808 active site 983545001809 phosphorylation site [posttranslational modification] 983545001810 intermolecular recognition site; other site 983545001811 dimerization interface [polypeptide binding]; other site 983545001812 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 983545001813 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 983545001814 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 983545001815 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 983545001816 CAP-like domain; other site 983545001817 active site 983545001818 primary dimer interface [polypeptide binding]; other site 983545001819 Carboxylesterase family; Region: COesterase; pfam00135 983545001820 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 983545001821 substrate binding pocket [chemical binding]; other site 983545001822 catalytic triad [active] 983545001823 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 983545001824 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983545001825 active site 983545001826 Zn binding site [ion binding]; other site 983545001827 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001828 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 983545001829 putative DNA binding site [nucleotide binding]; other site 983545001830 putative Zn2+ binding site [ion binding]; other site 983545001831 AsnC family; Region: AsnC_trans_reg; pfam01037 983545001832 putative peptidase; Provisional; Region: PRK11649 983545001833 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 983545001834 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545001835 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 983545001836 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 983545001837 active site 983545001838 HIGH motif; other site 983545001839 dimer interface [polypeptide binding]; other site 983545001840 KMSKS motif; other site 983545001841 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545001842 RNA binding surface [nucleotide binding]; other site 983545001843 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 983545001844 CobD/Cbib protein; Region: CobD_Cbib; cl00561 983545001845 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 983545001846 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 983545001847 acetyl-CoA synthetase; Provisional; Region: PRK00174 983545001848 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 983545001849 active site 983545001850 CoA binding site [chemical binding]; other site 983545001851 acyl-activating enzyme (AAE) consensus motif; other site 983545001852 AMP binding site [chemical binding]; other site 983545001853 acetate binding site [chemical binding]; other site 983545001854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545001855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001856 active site 983545001857 phosphorylation site [posttranslational modification] 983545001858 intermolecular recognition site; other site 983545001859 dimerization interface [polypeptide binding]; other site 983545001860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545001861 DNA binding residues [nucleotide binding] 983545001862 dimerization interface [polypeptide binding]; other site 983545001863 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 983545001864 Na binding site [ion binding]; other site 983545001865 PAS fold; Region: PAS_7; pfam12860 983545001866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545001867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545001868 dimer interface [polypeptide binding]; other site 983545001869 phosphorylation site [posttranslational modification] 983545001870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001871 ATP binding site [chemical binding]; other site 983545001872 Mg2+ binding site [ion binding]; other site 983545001873 G-X-G motif; other site 983545001874 Response regulator receiver domain; Region: Response_reg; pfam00072 983545001875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545001876 active site 983545001877 phosphorylation site [posttranslational modification] 983545001878 intermolecular recognition site; other site 983545001879 dimerization interface [polypeptide binding]; other site 983545001880 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 983545001881 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545001882 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 983545001883 Na binding site [ion binding]; other site 983545001884 FIST N domain; Region: FIST; pfam08495 983545001885 FIST C domain; Region: FIST_C; pfam10442 983545001886 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545001887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001888 metal binding site [ion binding]; metal-binding site 983545001889 active site 983545001890 I-site; other site 983545001891 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545001892 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 983545001893 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545001894 ligand binding site [chemical binding]; other site 983545001895 flexible hinge region; other site 983545001896 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 983545001897 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545001898 metal binding triad; other site 983545001899 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 983545001900 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545001901 active site 983545001902 catalytic site [active] 983545001903 substrate binding site [chemical binding]; other site 983545001904 TPR repeat; Region: TPR_11; pfam13414 983545001905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001906 binding surface 983545001907 TPR motif; other site 983545001908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545001909 binding surface 983545001910 TPR motif; other site 983545001911 TPR repeat; Region: TPR_11; pfam13414 983545001912 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 983545001913 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 983545001914 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 983545001915 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 983545001916 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 983545001917 Nucleoside recognition; Region: Gate; pfam07670 983545001918 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 983545001919 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 983545001920 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 983545001921 ATP-binding site [chemical binding]; other site 983545001922 Sugar specificity; other site 983545001923 Pyrimidine base specificity; other site 983545001924 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 983545001925 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983545001926 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545001927 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545001928 putative metal binding site [ion binding]; other site 983545001929 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983545001930 arginine repressor; Provisional; Region: PRK05066 983545001931 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 983545001932 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 983545001933 malate dehydrogenase; Provisional; Region: PRK05086 983545001934 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 983545001935 NAD binding site [chemical binding]; other site 983545001936 dimerization interface [polypeptide binding]; other site 983545001937 Substrate binding site [chemical binding]; other site 983545001938 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 983545001939 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 983545001940 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 983545001941 EF-hand domain pair; Region: EF_hand_5; pfam13499 983545001942 Ca2+ binding site [ion binding]; other site 983545001943 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 983545001944 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 983545001945 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 983545001946 Cl- selectivity filter; other site 983545001947 Cl- binding residues [ion binding]; other site 983545001948 pore gating glutamate residue; other site 983545001949 dimer interface [polypeptide binding]; other site 983545001950 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 983545001951 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 983545001952 homodecamer interface [polypeptide binding]; other site 983545001953 GTP cyclohydrolase I; Provisional; Region: PLN03044 983545001954 active site 983545001955 putative catalytic site residues [active] 983545001956 zinc binding site [ion binding]; other site 983545001957 GTP-CH-I/GFRP interaction surface; other site 983545001958 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 983545001959 hypothetical protein; Provisional; Region: PRK12378 983545001960 Predicted ATPase [General function prediction only]; Region: COG1485 983545001961 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 983545001962 Trypsin; Region: Trypsin; pfam00089 983545001963 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983545001964 protein binding site [polypeptide binding]; other site 983545001965 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983545001966 serine endoprotease; Provisional; Region: PRK10898 983545001967 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 983545001968 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 983545001969 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 983545001970 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 983545001971 hinge; other site 983545001972 active site 983545001973 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 983545001974 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545001975 anti sigma factor interaction site; other site 983545001976 regulatory phosphorylation site [posttranslational modification]; other site 983545001977 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 983545001978 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 983545001979 mce related protein; Region: MCE; pfam02470 983545001980 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 983545001981 conserved hypothetical integral membrane protein; Region: TIGR00056 983545001982 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 983545001983 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 983545001984 Walker A/P-loop; other site 983545001985 ATP binding site [chemical binding]; other site 983545001986 Q-loop/lid; other site 983545001987 ABC transporter signature motif; other site 983545001988 Walker B; other site 983545001989 D-loop; other site 983545001990 H-loop/switch region; other site 983545001991 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 983545001992 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 983545001993 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 983545001994 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 983545001995 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 983545001996 putative active site [active] 983545001997 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 983545001998 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 983545001999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 983545002000 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 983545002001 OstA-like protein; Region: OstA; cl00844 983545002002 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 983545002003 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 983545002004 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 983545002005 Walker A/P-loop; other site 983545002006 ATP binding site [chemical binding]; other site 983545002007 Q-loop/lid; other site 983545002008 ABC transporter signature motif; other site 983545002009 Walker B; other site 983545002010 D-loop; other site 983545002011 H-loop/switch region; other site 983545002012 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 983545002013 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 983545002014 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 983545002015 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 983545002016 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 983545002017 30S subunit binding site; other site 983545002018 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 983545002019 active site 983545002020 phosphorylation site [posttranslational modification] 983545002021 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 983545002022 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 983545002023 regulatory protein interface [polypeptide binding]; other site 983545002024 active site 983545002025 regulatory phosphorylation site [posttranslational modification]; other site 983545002026 Predicted transcriptional regulators [Transcription]; Region: COG1510 983545002027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545002028 putative DNA binding site [nucleotide binding]; other site 983545002029 putative Zn2+ binding site [ion binding]; other site 983545002030 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 983545002031 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 983545002032 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 983545002033 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 983545002034 PhnA protein; Region: PhnA; pfam03831 983545002035 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 983545002036 putative acyl-acceptor binding pocket; other site 983545002037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 983545002038 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 983545002039 active site 983545002040 substrate binding pocket [chemical binding]; other site 983545002041 dimer interface [polypeptide binding]; other site 983545002042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545002043 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545002044 substrate binding pocket [chemical binding]; other site 983545002045 membrane-bound complex binding site; other site 983545002046 hinge residues; other site 983545002047 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545002048 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545002049 substrate binding pocket [chemical binding]; other site 983545002050 membrane-bound complex binding site; other site 983545002051 hinge residues; other site 983545002052 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 983545002053 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545002054 substrate binding site [chemical binding]; other site 983545002055 oxyanion hole (OAH) forming residues; other site 983545002056 trimer interface [polypeptide binding]; other site 983545002057 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 983545002058 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545002059 ATP binding site [chemical binding]; other site 983545002060 Mg++ binding site [ion binding]; other site 983545002061 motif III; other site 983545002062 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545002063 nucleotide binding region [chemical binding]; other site 983545002064 ATP-binding site [chemical binding]; other site 983545002065 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 983545002066 putative RNA binding site [nucleotide binding]; other site 983545002067 PilZ domain; Region: PilZ; cl01260 983545002068 Predicted methyltransferase [General function prediction only]; Region: COG4798 983545002069 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 983545002070 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983545002071 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983545002072 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 983545002073 Walker A/P-loop; other site 983545002074 ATP binding site [chemical binding]; other site 983545002075 Q-loop/lid; other site 983545002076 ABC transporter signature motif; other site 983545002077 Walker B; other site 983545002078 D-loop; other site 983545002079 H-loop/switch region; other site 983545002080 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 983545002081 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 983545002082 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 983545002083 putative homodimer interface [polypeptide binding]; other site 983545002084 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 983545002085 heterodimer interface [polypeptide binding]; other site 983545002086 homodimer interface [polypeptide binding]; other site 983545002087 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 983545002088 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 983545002089 23S rRNA interface [nucleotide binding]; other site 983545002090 L7/L12 interface [polypeptide binding]; other site 983545002091 putative thiostrepton binding site; other site 983545002092 L25 interface [polypeptide binding]; other site 983545002093 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 983545002094 mRNA/rRNA interface [nucleotide binding]; other site 983545002095 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 983545002096 23S rRNA interface [nucleotide binding]; other site 983545002097 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 983545002098 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 983545002099 core dimer interface [polypeptide binding]; other site 983545002100 peripheral dimer interface [polypeptide binding]; other site 983545002101 L10 interface [polypeptide binding]; other site 983545002102 L11 interface [polypeptide binding]; other site 983545002103 putative EF-Tu interaction site [polypeptide binding]; other site 983545002104 putative EF-G interaction site [polypeptide binding]; other site 983545002105 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 983545002106 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 983545002107 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 983545002108 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 983545002109 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 983545002110 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 983545002111 RPB3 interaction site [polypeptide binding]; other site 983545002112 RPB1 interaction site [polypeptide binding]; other site 983545002113 RPB11 interaction site [polypeptide binding]; other site 983545002114 RPB10 interaction site [polypeptide binding]; other site 983545002115 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 983545002116 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 983545002117 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 983545002118 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 983545002119 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 983545002120 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 983545002121 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 983545002122 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 983545002123 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 983545002124 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 983545002125 DNA binding site [nucleotide binding] 983545002126 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 983545002127 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 983545002128 S17 interaction site [polypeptide binding]; other site 983545002129 S8 interaction site; other site 983545002130 16S rRNA interaction site [nucleotide binding]; other site 983545002131 streptomycin interaction site [chemical binding]; other site 983545002132 23S rRNA interaction site [nucleotide binding]; other site 983545002133 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 983545002134 30S ribosomal protein S7; Validated; Region: PRK05302 983545002135 elongation factor G; Reviewed; Region: PRK00007 983545002136 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 983545002137 G1 box; other site 983545002138 putative GEF interaction site [polypeptide binding]; other site 983545002139 GTP/Mg2+ binding site [chemical binding]; other site 983545002140 Switch I region; other site 983545002141 G2 box; other site 983545002142 G3 box; other site 983545002143 Switch II region; other site 983545002144 G4 box; other site 983545002145 G5 box; other site 983545002146 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 983545002147 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 983545002148 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 983545002149 elongation factor Tu; Reviewed; Region: PRK00049 983545002150 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 983545002151 G1 box; other site 983545002152 GEF interaction site [polypeptide binding]; other site 983545002153 GTP/Mg2+ binding site [chemical binding]; other site 983545002154 Switch I region; other site 983545002155 G2 box; other site 983545002156 G3 box; other site 983545002157 Switch II region; other site 983545002158 G4 box; other site 983545002159 G5 box; other site 983545002160 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 983545002161 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 983545002162 Antibiotic Binding Site [chemical binding]; other site 983545002163 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 983545002164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545002165 dimerization interface [polypeptide binding]; other site 983545002166 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545002167 dimer interface [polypeptide binding]; other site 983545002168 putative CheW interface [polypeptide binding]; other site 983545002169 hypothetical protein; Provisional; Region: PRK11568 983545002170 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 983545002171 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 983545002172 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 983545002173 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 983545002174 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 983545002175 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983545002176 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 983545002177 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545002178 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983545002179 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545002180 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 983545002181 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545002182 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 983545002183 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 983545002184 TrkA-N domain; Region: TrkA_N; pfam02254 983545002185 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983545002186 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002187 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 983545002188 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 983545002189 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545002190 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545002191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002192 metal binding site [ion binding]; metal-binding site 983545002193 active site 983545002194 I-site; other site 983545002195 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 983545002196 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545002197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545002198 catalytic residue [active] 983545002199 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 983545002200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545002201 ATP binding site [chemical binding]; other site 983545002202 putative Mg++ binding site [ion binding]; other site 983545002203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545002204 nucleotide binding region [chemical binding]; other site 983545002205 ATP-binding site [chemical binding]; other site 983545002206 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545002207 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545002208 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545002209 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545002210 Protein export membrane protein; Region: SecD_SecF; cl14618 983545002211 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545002212 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 983545002213 C-terminal domain interface [polypeptide binding]; other site 983545002214 GSH binding site (G-site) [chemical binding]; other site 983545002215 dimer interface [polypeptide binding]; other site 983545002216 Protein of unknown function (DUF1244); Region: DUF1244; pfam06844 983545002217 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545002218 CoenzymeA binding site [chemical binding]; other site 983545002219 subunit interaction site [polypeptide binding]; other site 983545002220 PHB binding site; other site 983545002221 hypothetical protein; Provisional; Region: PRK11027 983545002222 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 983545002223 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 983545002224 PYR/PP interface [polypeptide binding]; other site 983545002225 dimer interface [polypeptide binding]; other site 983545002226 TPP binding site [chemical binding]; other site 983545002227 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 983545002228 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 983545002229 TPP-binding site [chemical binding]; other site 983545002230 dimer interface [polypeptide binding]; other site 983545002231 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 983545002232 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 983545002233 putative valine binding site [chemical binding]; other site 983545002234 dimer interface [polypeptide binding]; other site 983545002235 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 983545002236 thymidine kinase; Provisional; Region: PRK04296 983545002237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545002238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002239 metal binding site [ion binding]; metal-binding site 983545002240 active site 983545002241 I-site; other site 983545002242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002243 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545002244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002245 DNA-binding site [nucleotide binding]; DNA binding site 983545002246 FCD domain; Region: FCD; pfam07729 983545002247 benzoate transporter; Region: benE; TIGR00843 983545002248 Benzoate membrane transport protein; Region: BenE; pfam03594 983545002249 bile acid transporter; Region: bass; TIGR00841 983545002250 Sodium Bile acid symporter family; Region: SBF; cl17470 983545002251 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545002252 short chain dehydrogenase; Provisional; Region: PRK08251 983545002253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002254 NAD(P) binding site [chemical binding]; other site 983545002255 active site 983545002256 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 983545002257 catalytic core [active] 983545002258 Phosphotransferase enzyme family; Region: APH; pfam01636 983545002259 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 983545002260 putative active site [active] 983545002261 putative substrate binding site [chemical binding]; other site 983545002262 ATP binding site [chemical binding]; other site 983545002263 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545002264 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545002265 active site 983545002266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545002267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545002268 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545002269 substrate binding pocket [chemical binding]; other site 983545002270 dimerization interface [polypeptide binding]; other site 983545002271 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 983545002272 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 983545002273 active site 983545002274 catalytic residues [active] 983545002275 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 983545002276 Putative Ig domain; Region: He_PIG; pfam05345 983545002277 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 983545002278 MgtE intracellular N domain; Region: MgtE_N; smart00924 983545002279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 983545002280 Divalent cation transporter; Region: MgtE; pfam01769 983545002281 EamA-like transporter family; Region: EamA; pfam00892 983545002282 galactokinase; Provisional; Region: PRK05101 983545002283 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 983545002284 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 983545002285 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 983545002286 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 983545002287 dimer interface [polypeptide binding]; other site 983545002288 active site 983545002289 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 983545002290 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 983545002291 NAD(P) binding site [chemical binding]; other site 983545002292 catalytic residues [active] 983545002293 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 983545002294 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 983545002295 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 983545002296 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983545002297 inhibitor-cofactor binding pocket; inhibition site 983545002298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545002299 catalytic residue [active] 983545002300 HDOD domain; Region: HDOD; pfam08668 983545002301 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 983545002302 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 983545002303 glutamine binding [chemical binding]; other site 983545002304 catalytic triad [active] 983545002305 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545002306 Ligand binding site [chemical binding]; other site 983545002307 Electron transfer flavoprotein domain; Region: ETF; pfam01012 983545002308 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545002309 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545002310 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983545002311 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545002312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545002313 active site 983545002314 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545002315 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 983545002316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545002317 SurA N-terminal domain; Region: SurA_N; pfam09312 983545002318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545002319 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 983545002320 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 983545002321 active site 983545002322 HIGH motif; other site 983545002323 dimer interface [polypeptide binding]; other site 983545002324 KMSKS motif; other site 983545002325 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 983545002326 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 983545002327 substrate binding site [chemical binding]; other site 983545002328 hexamer interface [polypeptide binding]; other site 983545002329 metal binding site [ion binding]; metal-binding site 983545002330 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 983545002331 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 983545002332 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 983545002333 cell division protein DamX; Validated; Region: PRK10905 983545002334 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 983545002335 active site 983545002336 dimer interface [polypeptide binding]; other site 983545002337 metal binding site [ion binding]; metal-binding site 983545002338 shikimate kinase; Reviewed; Region: aroK; PRK00131 983545002339 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 983545002340 ADP binding site [chemical binding]; other site 983545002341 magnesium binding site [ion binding]; other site 983545002342 putative shikimate binding site; other site 983545002343 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 983545002344 Secretin and TonB N terminus short domain; Region: STN; pfam07660 983545002345 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545002346 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 983545002347 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 983545002348 Pilus assembly protein, PilP; Region: PilP; pfam04351 983545002349 Pilus assembly protein, PilO; Region: PilO; pfam04350 983545002350 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 983545002351 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 983545002352 Competence protein A; Region: Competence_A; pfam11104 983545002353 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 983545002354 Transglycosylase; Region: Transgly; pfam00912 983545002355 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 983545002356 malate dehydrogenase; Provisional; Region: PRK13529 983545002357 Malic enzyme, N-terminal domain; Region: malic; pfam00390 983545002358 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 983545002359 NAD(P) binding site [chemical binding]; other site 983545002360 PAS domain S-box; Region: sensory_box; TIGR00229 983545002361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002362 putative active site [active] 983545002363 heme pocket [chemical binding]; other site 983545002364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545002365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545002366 dimer interface [polypeptide binding]; other site 983545002367 phosphorylation site [posttranslational modification] 983545002368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002369 ATP binding site [chemical binding]; other site 983545002370 Mg2+ binding site [ion binding]; other site 983545002371 G-X-G motif; other site 983545002372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545002374 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 983545002375 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 983545002376 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 983545002377 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 983545002378 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545002379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545002380 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545002381 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545002382 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983545002383 catalytic residues [active] 983545002384 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 983545002385 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545002387 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 983545002388 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 983545002389 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545002390 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545002391 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 983545002392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002393 putative substrate translocation pore; other site 983545002394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002395 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 983545002396 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 983545002397 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 983545002398 dimer interface [polypeptide binding]; other site 983545002399 active site 983545002400 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545002401 catalytic residues [active] 983545002402 substrate binding site [chemical binding]; other site 983545002403 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 983545002404 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 983545002405 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 983545002406 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 983545002407 AAA domain; Region: AAA_28; pfam13521 983545002408 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 983545002409 Kelch motif; Region: Kelch_1; pfam01344 983545002410 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 983545002411 Kelch motif; Region: Kelch_6; pfam13964 983545002412 Kelch domain; Region: Kelch; smart00612 983545002413 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545002414 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 983545002415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545002416 catalytic residue [active] 983545002417 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545002418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002419 metal binding site [ion binding]; metal-binding site 983545002420 active site 983545002421 I-site; other site 983545002422 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 983545002423 MAPEG family; Region: MAPEG; cl09190 983545002424 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002425 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 983545002426 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 983545002427 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 983545002428 AAA ATPase domain; Region: AAA_16; pfam13191 983545002429 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545002430 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545002431 DNA binding residues [nucleotide binding] 983545002432 dimerization interface [polypeptide binding]; other site 983545002433 Conserved TM helix; Region: TM_helix; pfam05552 983545002434 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545002435 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002436 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 983545002437 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545002438 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 983545002439 heme binding pocket [chemical binding]; other site 983545002440 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 983545002441 domain interactions; other site 983545002442 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545002443 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002444 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002445 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545002446 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 983545002447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545002448 binding surface 983545002449 TPR motif; other site 983545002450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545002451 TPR motif; other site 983545002452 binding surface 983545002453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545002454 binding surface 983545002455 TPR motif; other site 983545002456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545002457 TPR motif; other site 983545002458 binding surface 983545002459 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 983545002460 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 983545002461 short chain dehydrogenase; Provisional; Region: PRK12937 983545002462 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 983545002463 NADP binding site [chemical binding]; other site 983545002464 homodimer interface [polypeptide binding]; other site 983545002465 active site 983545002466 substrate binding site [chemical binding]; other site 983545002467 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 983545002468 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 983545002469 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 983545002470 DctM-like transporters; Region: DctM; pfam06808 983545002471 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 983545002472 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545002473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545002474 EamA-like transporter family; Region: EamA; pfam00892 983545002475 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545002476 EamA-like transporter family; Region: EamA; pfam00892 983545002477 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 983545002478 ArsC family; Region: ArsC; pfam03960 983545002479 catalytic residues [active] 983545002480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545002482 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545002483 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 983545002484 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002485 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545002486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002487 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 983545002488 NAD(P) binding site [chemical binding]; other site 983545002489 active site 983545002490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545002491 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545002492 active site 983545002493 metal binding site [ion binding]; metal-binding site 983545002494 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545002495 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545002496 active site 983545002497 metal binding site [ion binding]; metal-binding site 983545002498 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 983545002499 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 983545002500 Trp docking motif [polypeptide binding]; other site 983545002501 putative active site [active] 983545002502 DNA topoisomerase III; Provisional; Region: PRK07726 983545002503 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 983545002504 active site 983545002505 putative interdomain interaction site [polypeptide binding]; other site 983545002506 putative metal-binding site [ion binding]; other site 983545002507 putative nucleotide binding site [chemical binding]; other site 983545002508 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 983545002509 domain I; other site 983545002510 DNA binding groove [nucleotide binding] 983545002511 phosphate binding site [ion binding]; other site 983545002512 domain II; other site 983545002513 domain III; other site 983545002514 nucleotide binding site [chemical binding]; other site 983545002515 catalytic site [active] 983545002516 domain IV; other site 983545002517 PhoD-like phosphatase; Region: PhoD; pfam09423 983545002518 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545002519 active site 983545002520 metal binding site [ion binding]; metal-binding site 983545002521 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 983545002522 Na binding site [ion binding]; other site 983545002523 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 983545002524 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 983545002525 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 983545002526 putative chaperone; Provisional; Region: PRK11678 983545002527 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 983545002528 nucleotide binding site [chemical binding]; other site 983545002529 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 983545002530 putative NEF/HSP70 interaction site [polypeptide binding]; other site 983545002531 nucleotide binding site [chemical binding]; other site 983545002532 SBD interface [polypeptide binding]; other site 983545002533 YHYH protein; Region: YHYH; pfam14240 983545002534 YHYH protein; Region: YHYH; pfam14240 983545002535 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545002536 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545002537 active site 983545002538 metal binding site [ion binding]; metal-binding site 983545002539 Secretin and TonB N terminus short domain; Region: STN; smart00965 983545002540 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002541 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002542 N-terminal plug; other site 983545002543 ligand-binding site [chemical binding]; other site 983545002544 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545002545 FecR protein; Region: FecR; pfam04773 983545002546 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545002547 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545002548 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 983545002549 DNA binding residues [nucleotide binding] 983545002550 PEP-CTERM motif; Region: VPEP; pfam07589 983545002551 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 983545002552 active site 983545002553 catalytic motif [active] 983545002554 Zn binding site [ion binding]; other site 983545002555 lipoprotein NlpI; Provisional; Region: PRK11189 983545002556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545002557 binding surface 983545002558 TPR motif; other site 983545002559 quinolinate synthetase; Provisional; Region: PRK09375 983545002560 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 983545002561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545002562 motif II; other site 983545002563 Predicted transcriptional regulator [Transcription]; Region: COG2378 983545002564 HTH domain; Region: HTH_11; pfam08279 983545002565 WYL domain; Region: WYL; pfam13280 983545002566 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545002567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545002568 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 983545002569 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002570 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002571 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002572 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 983545002573 ligand binding site [chemical binding]; other site 983545002574 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545002575 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545002576 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545002577 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 983545002578 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545002579 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545002580 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 983545002581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545002582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002583 metal binding site [ion binding]; metal-binding site 983545002584 active site 983545002585 I-site; other site 983545002586 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 983545002587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002588 DNA-binding site [nucleotide binding]; DNA binding site 983545002589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545002590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545002591 homodimer interface [polypeptide binding]; other site 983545002592 catalytic residue [active] 983545002593 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 983545002594 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 983545002595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545002596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002597 ATP binding site [chemical binding]; other site 983545002598 Mg2+ binding site [ion binding]; other site 983545002599 G-X-G motif; other site 983545002600 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545002601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002602 active site 983545002603 phosphorylation site [posttranslational modification] 983545002604 intermolecular recognition site; other site 983545002605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545002606 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 983545002607 putative active site [active] 983545002608 heme pocket [chemical binding]; other site 983545002609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545002610 dimer interface [polypeptide binding]; other site 983545002611 phosphorylation site [posttranslational modification] 983545002612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002613 ATP binding site [chemical binding]; other site 983545002614 Mg2+ binding site [ion binding]; other site 983545002615 G-X-G motif; other site 983545002616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002617 Response regulator receiver domain; Region: Response_reg; pfam00072 983545002618 active site 983545002619 phosphorylation site [posttranslational modification] 983545002620 intermolecular recognition site; other site 983545002621 dimerization interface [polypeptide binding]; other site 983545002622 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545002623 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002624 metal binding site [ion binding]; metal-binding site 983545002625 active site 983545002626 I-site; other site 983545002627 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002628 Response regulator receiver domain; Region: Response_reg; pfam00072 983545002629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002630 active site 983545002631 phosphorylation site [posttranslational modification] 983545002632 intermolecular recognition site; other site 983545002633 dimerization interface [polypeptide binding]; other site 983545002634 Hpt domain; Region: Hpt; pfam01627 983545002635 putative binding surface; other site 983545002636 active site 983545002637 Response regulator receiver domain; Region: Response_reg; pfam00072 983545002638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545002639 active site 983545002640 phosphorylation site [posttranslational modification] 983545002641 intermolecular recognition site; other site 983545002642 dimerization interface [polypeptide binding]; other site 983545002643 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545002644 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002645 metal binding site [ion binding]; metal-binding site 983545002646 active site 983545002647 I-site; other site 983545002648 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002649 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545002650 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002651 metal binding site [ion binding]; metal-binding site 983545002652 active site 983545002653 I-site; other site 983545002654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545002655 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 983545002656 Walker A motif; other site 983545002657 ATP binding site [chemical binding]; other site 983545002658 Walker B motif; other site 983545002659 arginine finger; other site 983545002660 Uncharacterized conserved protein [Function unknown]; Region: COG1359 983545002661 Uncharacterized conserved protein [Function unknown]; Region: COG1359 983545002662 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 983545002663 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 983545002664 active site 983545002665 catalytic residues [active] 983545002666 glycerol kinase; Provisional; Region: glpK; PRK00047 983545002667 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 983545002668 N- and C-terminal domain interface [polypeptide binding]; other site 983545002669 active site 983545002670 MgATP binding site [chemical binding]; other site 983545002671 catalytic site [active] 983545002672 metal binding site [ion binding]; metal-binding site 983545002673 glycerol binding site [chemical binding]; other site 983545002674 homotetramer interface [polypeptide binding]; other site 983545002675 homodimer interface [polypeptide binding]; other site 983545002676 FBP binding site [chemical binding]; other site 983545002677 protein IIAGlc interface [polypeptide binding]; other site 983545002678 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545002679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002680 DNA-binding site [nucleotide binding]; DNA binding site 983545002681 FCD domain; Region: FCD; pfam07729 983545002682 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 983545002683 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 983545002684 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 983545002685 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545002686 classical (c) SDRs; Region: SDR_c; cd05233 983545002687 NAD(P) binding site [chemical binding]; other site 983545002688 active site 983545002689 cell division protein MraZ; Reviewed; Region: PRK00326 983545002690 MraZ protein; Region: MraZ; pfam02381 983545002691 MraZ protein; Region: MraZ; pfam02381 983545002692 MraW methylase family; Region: Methyltransf_5; pfam01795 983545002693 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 983545002694 Cell division protein FtsL; Region: FtsL; pfam04999 983545002695 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 983545002696 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 983545002697 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 983545002698 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 983545002699 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002700 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002701 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002702 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 983545002703 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002704 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002705 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002706 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 983545002707 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 983545002708 Mg++ binding site [ion binding]; other site 983545002709 putative catalytic motif [active] 983545002710 putative substrate binding site [chemical binding]; other site 983545002711 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 983545002712 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002713 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002714 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 983545002715 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 983545002716 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 983545002717 active site 983545002718 homodimer interface [polypeptide binding]; other site 983545002719 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 983545002720 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002721 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002722 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002723 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 983545002724 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 983545002725 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983545002726 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 983545002727 Cell division protein FtsQ; Region: FtsQ; pfam03799 983545002728 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 983545002729 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 983545002730 nucleotide binding site [chemical binding]; other site 983545002731 Cell division protein FtsA; Region: FtsA; pfam14450 983545002732 cell division protein FtsZ; Validated; Region: PRK09330 983545002733 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 983545002734 nucleotide binding site [chemical binding]; other site 983545002735 SulA interaction site; other site 983545002736 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 983545002737 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 983545002738 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983545002739 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545002740 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 983545002741 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 983545002742 SEC-C motif; Region: SEC-C; pfam02810 983545002743 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 983545002744 active site 983545002745 8-oxo-dGMP binding site [chemical binding]; other site 983545002746 nudix motif; other site 983545002747 metal binding site [ion binding]; metal-binding site 983545002748 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 983545002749 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983545002750 active site 983545002751 dimer interface [polypeptide binding]; other site 983545002752 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 983545002753 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 983545002754 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 983545002755 active site 983545002756 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545002757 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 983545002758 substrate binding site [chemical binding]; other site 983545002759 dimer interface [polypeptide binding]; other site 983545002760 ATP binding site [chemical binding]; other site 983545002761 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 983545002762 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 983545002763 proline aminopeptidase P II; Provisional; Region: PRK10879 983545002764 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 983545002765 active site 983545002766 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 983545002767 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 983545002768 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 983545002769 putative deacylase active site [active] 983545002770 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 983545002771 Aerotolerance regulator N-terminal; Region: BatA; cl06567 983545002772 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 983545002773 Protein of unknown function DUF58; Region: DUF58; pfam01882 983545002774 MoxR-like ATPases [General function prediction only]; Region: COG0714 983545002775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545002776 Walker A motif; other site 983545002777 ATP binding site [chemical binding]; other site 983545002778 Walker B motif; other site 983545002779 arginine finger; other site 983545002780 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 983545002781 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 983545002782 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 983545002783 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545002784 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 983545002785 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 983545002786 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 983545002787 active site 983545002788 Methyltransferase domain; Region: Methyltransf_32; pfam13679 983545002789 MerC mercury resistance protein; Region: MerC; pfam03203 983545002790 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 983545002791 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545002792 active site 983545002793 catalytic site [active] 983545002794 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 983545002795 EamA-like transporter family; Region: EamA; pfam00892 983545002796 EamA-like transporter family; Region: EamA; pfam00892 983545002797 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 983545002798 GTPase RsgA; Reviewed; Region: PRK12288 983545002799 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983545002800 RNA binding site [nucleotide binding]; other site 983545002801 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 983545002802 GTPase/Zn-binding domain interface [polypeptide binding]; other site 983545002803 GTP/Mg2+ binding site [chemical binding]; other site 983545002804 G4 box; other site 983545002805 G5 box; other site 983545002806 G1 box; other site 983545002807 Switch I region; other site 983545002808 G2 box; other site 983545002809 G3 box; other site 983545002810 Switch II region; other site 983545002811 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 983545002812 catalytic site [active] 983545002813 putative active site [active] 983545002814 putative substrate binding site [chemical binding]; other site 983545002815 dimer interface [polypeptide binding]; other site 983545002816 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 983545002817 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 983545002818 active site 983545002819 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 983545002820 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545002821 active site 983545002822 ATP binding site [chemical binding]; other site 983545002823 substrate binding site [chemical binding]; other site 983545002824 activation loop (A-loop); other site 983545002825 cyanate hydratase; Validated; Region: PRK02866 983545002826 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 983545002827 oligomer interface [polypeptide binding]; other site 983545002828 active site 983545002829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002830 PAS domain; Region: PAS_9; pfam13426 983545002831 putative active site [active] 983545002832 heme pocket [chemical binding]; other site 983545002833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002834 PAS domain; Region: PAS_9; pfam13426 983545002835 putative active site [active] 983545002836 heme pocket [chemical binding]; other site 983545002837 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545002838 dimer interface [polypeptide binding]; other site 983545002839 putative CheW interface [polypeptide binding]; other site 983545002840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 983545002841 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 983545002842 GAF domain; Region: GAF; pfam01590 983545002843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545002844 Walker A motif; other site 983545002845 ATP binding site [chemical binding]; other site 983545002846 Walker B motif; other site 983545002847 arginine finger; other site 983545002848 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 983545002849 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 983545002850 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 983545002851 heme-binding site [chemical binding]; other site 983545002852 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 983545002853 FAD binding pocket [chemical binding]; other site 983545002854 FAD binding motif [chemical binding]; other site 983545002855 phosphate binding motif [ion binding]; other site 983545002856 beta-alpha-beta structure motif; other site 983545002857 NAD binding pocket [chemical binding]; other site 983545002858 Heme binding pocket [chemical binding]; other site 983545002859 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 983545002860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545002861 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 983545002862 RNA binding surface [nucleotide binding]; other site 983545002863 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 983545002864 active site 983545002865 uracil binding [chemical binding]; other site 983545002866 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 983545002867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545002868 dimerization interface [polypeptide binding]; other site 983545002869 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545002870 dimer interface [polypeptide binding]; other site 983545002871 putative CheW interface [polypeptide binding]; other site 983545002872 Protein of unknown function (DUF502); Region: DUF502; cl01107 983545002873 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 983545002874 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 983545002875 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983545002876 glutaredoxin 2; Provisional; Region: PRK10387 983545002877 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545002878 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 983545002879 N-terminal domain interface [polypeptide binding]; other site 983545002880 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 983545002881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545002882 ATP binding site [chemical binding]; other site 983545002883 putative Mg++ binding site [ion binding]; other site 983545002884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545002885 nucleotide binding region [chemical binding]; other site 983545002886 ATP-binding site [chemical binding]; other site 983545002887 Double zinc ribbon; Region: DZR; pfam12773 983545002888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002889 D-galactonate transporter; Region: 2A0114; TIGR00893 983545002890 putative substrate translocation pore; other site 983545002891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545002892 AAA domain; Region: AAA_23; pfam13476 983545002893 Walker A/P-loop; other site 983545002894 ATP binding site [chemical binding]; other site 983545002895 Q-loop/lid; other site 983545002896 exonuclease subunit SbcC; Provisional; Region: PRK10246 983545002897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545002898 ABC transporter signature motif; other site 983545002899 Walker B; other site 983545002900 D-loop; other site 983545002901 H-loop/switch region; other site 983545002902 exonuclease subunit SbcD; Provisional; Region: PRK10966 983545002903 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 983545002904 active site 983545002905 metal binding site [ion binding]; metal-binding site 983545002906 DNA binding site [nucleotide binding] 983545002907 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 983545002908 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002909 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002910 N-terminal plug; other site 983545002911 ligand-binding site [chemical binding]; other site 983545002912 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 983545002913 Ecdysteroid kinase; Region: EcKinase; cl17738 983545002914 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545002915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002916 putative active site [active] 983545002917 heme pocket [chemical binding]; other site 983545002918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545002919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002920 metal binding site [ion binding]; metal-binding site 983545002921 active site 983545002922 I-site; other site 983545002923 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002924 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 983545002925 active site 983545002926 catalytic triad [active] 983545002927 oxyanion hole [active] 983545002928 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 983545002929 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983545002930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545002931 Walker A/P-loop; other site 983545002932 ATP binding site [chemical binding]; other site 983545002933 Q-loop/lid; other site 983545002934 ABC transporter signature motif; other site 983545002935 Walker B; other site 983545002936 D-loop; other site 983545002937 H-loop/switch region; other site 983545002938 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 983545002939 active site 983545002940 catalytic residues [active] 983545002941 metal binding site [ion binding]; metal-binding site 983545002942 Transglycosylase SLT domain; Region: SLT_2; pfam13406 983545002943 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983545002944 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545002945 catalytic residue [active] 983545002946 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 983545002947 hypothetical protein; Provisional; Region: PRK01254 983545002948 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 983545002949 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 983545002950 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 983545002951 intracellular protease, PfpI family; Region: PfpI; TIGR01382 983545002952 proposed catalytic triad [active] 983545002953 conserved cys residue [active] 983545002954 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 983545002955 Strictosidine synthase; Region: Str_synth; pfam03088 983545002956 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 983545002957 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 983545002958 substrate binding site [chemical binding]; other site 983545002959 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 983545002960 substrate binding site [chemical binding]; other site 983545002961 ligand binding site [chemical binding]; other site 983545002962 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 983545002963 amidase; Provisional; Region: PRK08137 983545002964 Amidase; Region: Amidase; pfam01425 983545002965 aspartate kinase III; Validated; Region: PRK09084 983545002966 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 983545002967 nucleotide binding site [chemical binding]; other site 983545002968 putative catalytic residues [active] 983545002969 aspartate binding site [chemical binding]; other site 983545002970 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 983545002971 lysine allosteric regulatory site; other site 983545002972 dimer interface [polypeptide binding]; other site 983545002973 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 983545002974 dimer interface [polypeptide binding]; other site 983545002975 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545002976 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545002977 dimer interface [polypeptide binding]; other site 983545002978 putative CheW interface [polypeptide binding]; other site 983545002979 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 983545002980 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 983545002981 active site 983545002982 metal binding site [ion binding]; metal-binding site 983545002983 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 983545002984 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 983545002985 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 983545002986 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 983545002987 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 983545002988 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 983545002989 SurA N-terminal domain; Region: SurA_N; pfam09312 983545002990 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 983545002991 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 983545002992 OstA-like protein; Region: OstA; cl00844 983545002993 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 983545002994 Organic solvent tolerance protein; Region: OstA_C; pfam04453 983545002995 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 983545002996 Phosphotransferase enzyme family; Region: APH; pfam01636 983545002997 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 983545002998 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 983545002999 Substrate binding site; other site 983545003000 metal-binding site 983545003001 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 983545003002 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 983545003003 putative metal binding site [ion binding]; other site 983545003004 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 983545003005 HSP70 interaction site [polypeptide binding]; other site 983545003006 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545003007 N-terminal plug; other site 983545003008 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 983545003009 ligand-binding site [chemical binding]; other site 983545003010 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545003011 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 983545003012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545003013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545003014 dimerization interface [polypeptide binding]; other site 983545003015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545003016 dimer interface [polypeptide binding]; other site 983545003017 phosphorylation site [posttranslational modification] 983545003018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003019 ATP binding site [chemical binding]; other site 983545003020 Mg2+ binding site [ion binding]; other site 983545003021 G-X-G motif; other site 983545003022 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545003023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003024 active site 983545003025 phosphorylation site [posttranslational modification] 983545003026 intermolecular recognition site; other site 983545003027 dimerization interface [polypeptide binding]; other site 983545003028 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545003029 DNA binding site [nucleotide binding] 983545003030 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545003031 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545003032 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545003033 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 983545003034 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 983545003035 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 983545003036 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 983545003037 homodimer interface [polypeptide binding]; other site 983545003038 substrate-cofactor binding pocket; other site 983545003039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545003040 catalytic residue [active] 983545003041 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 983545003042 MltA-interacting protein MipA; Region: MipA; cl01504 983545003043 YcxB-like protein; Region: YcxB; pfam14317 983545003044 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545003045 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545003046 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 983545003047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545003048 putative DNA binding site [nucleotide binding]; other site 983545003049 dimerization interface [polypeptide binding]; other site 983545003050 putative Zn2+ binding site [ion binding]; other site 983545003051 Low molecular weight phosphatase family; Region: LMWPc; cd00115 983545003052 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 983545003053 active site 983545003054 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 983545003055 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 983545003056 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 983545003057 arsenical-resistance protein; Region: acr3; TIGR00832 983545003058 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 983545003059 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 983545003060 putative trimer interface [polypeptide binding]; other site 983545003061 putative CoA binding site [chemical binding]; other site 983545003062 Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718 983545003063 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 983545003064 ATP binding site [chemical binding]; other site 983545003065 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 983545003066 catalytic motif [active] 983545003067 Catalytic residue [active] 983545003068 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545003069 active site 983545003070 Domain of unknown function (DUF1083); Region: DUF1083; pfam06452 983545003071 putative ligand binding site [chemical binding]; other site 983545003072 Protein of unknown function, DUF462; Region: DUF462; pfam04315 983545003073 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 983545003074 ATP-NAD kinase; Region: NAD_kinase; pfam01513 983545003075 YfcL protein; Region: YfcL; pfam08891 983545003076 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 983545003077 Uncharacterized conserved protein [Function unknown]; Region: COG4121 983545003078 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 983545003079 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983545003080 dimer interface [polypeptide binding]; other site 983545003081 active site 983545003082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003083 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545003084 putative substrate translocation pore; other site 983545003085 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 983545003086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 983545003087 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 983545003088 Protein of unknown function (DUF1414); Region: DUF1414; cl01175 983545003089 Nucleoid-associated protein [General function prediction only]; Region: COG3081 983545003090 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 983545003091 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 983545003092 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983545003093 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545003094 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 983545003095 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 983545003096 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545003097 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545003098 metal binding site [ion binding]; metal-binding site 983545003099 active site 983545003100 I-site; other site 983545003101 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545003102 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983545003103 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545003104 ligand binding site [chemical binding]; other site 983545003105 flexible hinge region; other site 983545003106 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 983545003107 aldolase II superfamily protein; Provisional; Region: PRK07044 983545003108 intersubunit interface [polypeptide binding]; other site 983545003109 active site 983545003110 Zn2+ binding site [ion binding]; other site 983545003111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545003112 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 983545003113 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 983545003114 ligand binding site [chemical binding]; other site 983545003115 NAD binding site [chemical binding]; other site 983545003116 catalytic site [active] 983545003117 homodimer interface [polypeptide binding]; other site 983545003118 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 983545003119 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 983545003120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545003121 Walker A/P-loop; other site 983545003122 ATP binding site [chemical binding]; other site 983545003123 Q-loop/lid; other site 983545003124 ABC transporter signature motif; other site 983545003125 FimV N-terminal domain; Region: FimV_core; TIGR03505 983545003126 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 983545003127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545003128 dimerization interface [polypeptide binding]; other site 983545003129 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545003130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545003131 metal binding site [ion binding]; metal-binding site 983545003132 active site 983545003133 I-site; other site 983545003134 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545003135 Protein of unknown function, DUF481; Region: DUF481; pfam04338 983545003136 Protein of unknown function, DUF481; Region: DUF481; pfam04338 983545003137 HDOD domain; Region: HDOD; pfam08668 983545003138 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545003139 TAP-like protein; Region: Abhydrolase_4; pfam08386 983545003140 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 983545003141 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 983545003142 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 983545003143 active site 983545003144 Zn binding site [ion binding]; other site 983545003145 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 983545003146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545003147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545003148 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545003149 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545003150 E3 interaction surface; other site 983545003151 lipoyl attachment site [posttranslational modification]; other site 983545003152 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 983545003153 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545003154 E3 interaction surface; other site 983545003155 lipoyl attachment site [posttranslational modification]; other site 983545003156 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545003157 E3 interaction surface; other site 983545003158 lipoyl attachment site [posttranslational modification]; other site 983545003159 e3 binding domain; Region: E3_binding; pfam02817 983545003160 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 983545003161 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 983545003162 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 983545003163 dimer interface [polypeptide binding]; other site 983545003164 TPP-binding site [chemical binding]; other site 983545003165 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 983545003166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545003167 DNA-binding site [nucleotide binding]; DNA binding site 983545003168 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 983545003169 regulatory protein AmpE; Provisional; Region: PRK10987 983545003170 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 983545003171 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 983545003172 amidase catalytic site [active] 983545003173 Zn binding residues [ion binding]; other site 983545003174 substrate binding site [chemical binding]; other site 983545003175 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 983545003176 catalytic motif [active] 983545003177 Catalytic residue [active] 983545003178 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 983545003179 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 983545003180 dimerization interface [polypeptide binding]; other site 983545003181 active site 983545003182 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 983545003183 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 983545003184 Pilin (bacterial filament); Region: Pilin; pfam00114 983545003185 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545003186 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 983545003187 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 983545003188 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 983545003189 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 983545003190 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 983545003191 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 983545003192 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 983545003193 CoA-binding site [chemical binding]; other site 983545003194 hypothetical protein; Provisional; Region: PRK05287 983545003195 Domain of unknown function (DUF329); Region: DUF329; pfam03884 983545003196 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 983545003197 catalytic triad [active] 983545003198 dimer interface [polypeptide binding]; other site 983545003199 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545003200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545003201 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 983545003202 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545003203 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 983545003204 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 983545003205 dimer interface [polypeptide binding]; other site 983545003206 N-terminal domain interface [polypeptide binding]; other site 983545003207 substrate binding pocket (H-site) [chemical binding]; other site 983545003208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545003209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 983545003210 dimer interface [polypeptide binding]; other site 983545003211 phosphorylation site [posttranslational modification] 983545003212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003213 ATP binding site [chemical binding]; other site 983545003214 Mg2+ binding site [ion binding]; other site 983545003215 G-X-G motif; other site 983545003216 RNA methyltransferase, RsmE family; Region: TIGR00046 983545003217 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 983545003218 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545003219 Peptidase family M48; Region: Peptidase_M48; pfam01435 983545003220 S-adenosylmethionine synthetase; Validated; Region: PRK05250 983545003221 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 983545003222 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 983545003223 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 983545003224 transketolase; Reviewed; Region: PRK12753 983545003225 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 983545003226 TPP-binding site [chemical binding]; other site 983545003227 dimer interface [polypeptide binding]; other site 983545003228 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 983545003229 PYR/PP interface [polypeptide binding]; other site 983545003230 dimer interface [polypeptide binding]; other site 983545003231 TPP binding site [chemical binding]; other site 983545003232 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983545003233 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 983545003234 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 983545003235 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983545003236 Phosphoglycerate kinase; Region: PGK; pfam00162 983545003237 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 983545003238 substrate binding site [chemical binding]; other site 983545003239 hinge regions; other site 983545003240 ADP binding site [chemical binding]; other site 983545003241 catalytic site [active] 983545003242 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 983545003243 catalytic residue [active] 983545003244 HD domain; Region: HD_3; pfam13023 983545003245 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 983545003246 exopolyphosphatase; Provisional; Region: PRK10854 983545003247 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 983545003248 nucleotide binding site [chemical binding]; other site 983545003249 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 983545003250 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 983545003251 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 983545003252 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 983545003253 domain interface [polypeptide binding]; other site 983545003254 active site 983545003255 catalytic site [active] 983545003256 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 983545003257 putative active site [active] 983545003258 catalytic site [active] 983545003259 ACT domain; Region: ACT_6; pfam13740 983545003260 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 983545003261 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 983545003262 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 983545003263 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 983545003264 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 983545003265 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 983545003266 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 983545003267 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 983545003268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545003269 dimer interface [polypeptide binding]; other site 983545003270 conserved gate region; other site 983545003271 putative PBP binding loops; other site 983545003272 ABC-ATPase subunit interface; other site 983545003273 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 983545003274 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 983545003275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545003276 dimer interface [polypeptide binding]; other site 983545003277 conserved gate region; other site 983545003278 putative PBP binding loops; other site 983545003279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 983545003280 ABC-ATPase subunit interface; other site 983545003281 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 983545003282 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 983545003283 Walker A/P-loop; other site 983545003284 ATP binding site [chemical binding]; other site 983545003285 Q-loop/lid; other site 983545003286 ABC transporter signature motif; other site 983545003287 Walker B; other site 983545003288 D-loop; other site 983545003289 H-loop/switch region; other site 983545003290 transcriptional regulator PhoU; Provisional; Region: PRK11115 983545003291 PhoU domain; Region: PhoU; pfam01895 983545003292 PhoU domain; Region: PhoU; pfam01895 983545003293 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 983545003294 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 983545003295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545003296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545003297 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 983545003298 dimerization interface [polypeptide binding]; other site 983545003299 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545003300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545003301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545003302 DNA binding residues [nucleotide binding] 983545003303 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 983545003304 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545003305 CoenzymeA binding site [chemical binding]; other site 983545003306 subunit interaction site [polypeptide binding]; other site 983545003307 PHB binding site; other site 983545003308 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545003309 MgtC family; Region: MgtC; pfam02308 983545003310 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 983545003311 NADH(P)-binding; Region: NAD_binding_10; pfam13460 983545003312 NAD binding site [chemical binding]; other site 983545003313 substrate binding site [chemical binding]; other site 983545003314 putative active site [active] 983545003315 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545003316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545003317 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545003318 putative effector binding pocket; other site 983545003319 dimerization interface [polypeptide binding]; other site 983545003320 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 983545003321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003322 putative substrate translocation pore; other site 983545003323 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545003324 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 983545003325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003326 putative substrate translocation pore; other site 983545003327 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 983545003328 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983545003329 dimer interface [polypeptide binding]; other site 983545003330 active site 983545003331 CoA binding pocket [chemical binding]; other site 983545003332 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 983545003333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003334 ATP binding site [chemical binding]; other site 983545003335 Mg2+ binding site [ion binding]; other site 983545003336 G-X-G motif; other site 983545003337 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 983545003338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003339 active site 983545003340 phosphorylation site [posttranslational modification] 983545003341 intermolecular recognition site; other site 983545003342 dimerization interface [polypeptide binding]; other site 983545003343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003344 Walker A motif; other site 983545003345 ATP binding site [chemical binding]; other site 983545003346 Walker B motif; other site 983545003347 arginine finger; other site 983545003348 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 983545003349 LrgA family; Region: LrgA; pfam03788 983545003350 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 983545003351 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545003352 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545003353 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 983545003354 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 983545003355 DNA methylase; Region: N6_N4_Mtase; pfam01555 983545003356 HemN family oxidoreductase; Provisional; Region: PRK05660 983545003357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545003358 FeS/SAM binding site; other site 983545003359 HemN C-terminal domain; Region: HemN_C; pfam06969 983545003360 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 983545003361 active site 983545003362 dimerization interface [polypeptide binding]; other site 983545003363 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 983545003364 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 983545003365 short chain dehydrogenase; Provisional; Region: PRK06197 983545003366 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 983545003367 putative NAD(P) binding site [chemical binding]; other site 983545003368 active site 983545003369 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 983545003370 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545003371 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 983545003372 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 983545003373 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545003374 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545003375 ATP binding site [chemical binding]; other site 983545003376 Mg++ binding site [ion binding]; other site 983545003377 motif III; other site 983545003378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545003379 nucleotide binding region [chemical binding]; other site 983545003380 ATP-binding site [chemical binding]; other site 983545003381 dUTPase; Region: dUTPase_2; pfam08761 983545003382 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 983545003383 active site 983545003384 homodimer interface [polypeptide binding]; other site 983545003385 metal binding site [ion binding]; metal-binding site 983545003386 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 983545003387 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 983545003388 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 983545003389 active site 983545003390 NTP binding site [chemical binding]; other site 983545003391 metal binding triad [ion binding]; metal-binding site 983545003392 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 983545003393 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545003394 Zn2+ binding site [ion binding]; other site 983545003395 Mg2+ binding site [ion binding]; other site 983545003396 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 983545003397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 983545003398 Walker A motif; other site 983545003399 ATP binding site [chemical binding]; other site 983545003400 Walker B motif; other site 983545003401 arginine finger; other site 983545003402 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 983545003403 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545003404 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545003405 substrate binding pocket [chemical binding]; other site 983545003406 membrane-bound complex binding site; other site 983545003407 hinge residues; other site 983545003408 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545003409 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545003410 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545003411 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545003412 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545003413 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545003414 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 983545003415 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 983545003416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003417 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 983545003418 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 983545003419 catalytic domain interface [polypeptide binding]; other site 983545003420 homodimer interface [polypeptide binding]; other site 983545003421 putative active site [active] 983545003422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 983545003423 CreA protein; Region: CreA; pfam05981 983545003424 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545003425 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545003426 DNA binding site [nucleotide binding] 983545003427 domain linker motif; other site 983545003428 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545003429 dimerization interface [polypeptide binding]; other site 983545003430 ligand binding site [chemical binding]; other site 983545003431 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 983545003432 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 983545003433 substrate binding site [chemical binding]; other site 983545003434 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 983545003435 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 983545003436 substrate binding site [chemical binding]; other site 983545003437 ligand binding site [chemical binding]; other site 983545003438 tartrate dehydrogenase; Region: TTC; TIGR02089 983545003439 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 983545003440 2-isopropylmalate synthase; Validated; Region: PRK00915 983545003441 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 983545003442 active site 983545003443 catalytic residues [active] 983545003444 metal binding site [ion binding]; metal-binding site 983545003445 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 983545003446 enolase; Provisional; Region: eno; PRK00077 983545003447 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 983545003448 dimer interface [polypeptide binding]; other site 983545003449 metal binding site [ion binding]; metal-binding site 983545003450 substrate binding pocket [chemical binding]; other site 983545003451 CTP synthetase; Validated; Region: pyrG; PRK05380 983545003452 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 983545003453 Catalytic site [active] 983545003454 active site 983545003455 UTP binding site [chemical binding]; other site 983545003456 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 983545003457 active site 983545003458 putative oxyanion hole; other site 983545003459 catalytic triad [active] 983545003460 Response regulator receiver domain; Region: Response_reg; pfam00072 983545003461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003462 active site 983545003463 phosphorylation site [posttranslational modification] 983545003464 intermolecular recognition site; other site 983545003465 dimerization interface [polypeptide binding]; other site 983545003466 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 983545003467 MutS domain I; Region: MutS_I; pfam01624 983545003468 MutS domain II; Region: MutS_II; pfam05188 983545003469 MutS domain III; Region: MutS_III; pfam05192 983545003470 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 983545003471 Walker A/P-loop; other site 983545003472 ATP binding site [chemical binding]; other site 983545003473 Q-loop/lid; other site 983545003474 ABC transporter signature motif; other site 983545003475 Walker B; other site 983545003476 D-loop; other site 983545003477 H-loop/switch region; other site 983545003478 Competence-damaged protein; Region: CinA; cl00666 983545003479 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 983545003480 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 983545003481 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 983545003482 recombinase A; Provisional; Region: recA; PRK09354 983545003483 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 983545003484 hexamer interface [polypeptide binding]; other site 983545003485 Walker A motif; other site 983545003486 ATP binding site [chemical binding]; other site 983545003487 Walker B motif; other site 983545003488 Cupin-like domain; Region: Cupin_8; pfam13621 983545003489 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 983545003490 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 983545003491 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 983545003492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545003493 Walker A/P-loop; other site 983545003494 ATP binding site [chemical binding]; other site 983545003495 Q-loop/lid; other site 983545003496 ABC transporter signature motif; other site 983545003497 Walker B; other site 983545003498 D-loop; other site 983545003499 H-loop/switch region; other site 983545003500 heme exporter protein CcmB; Region: ccmB; TIGR01190 983545003501 heme exporter protein CcmC; Region: ccmC; TIGR01191 983545003502 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 983545003503 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 983545003504 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 983545003505 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 983545003506 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545003507 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 983545003508 TPR repeat; Region: TPR_11; pfam13414 983545003509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545003510 binding surface 983545003511 TPR motif; other site 983545003512 VacJ like lipoprotein; Region: VacJ; cl01073 983545003513 UDP-glucose 4-epimerase; Region: PLN02240 983545003514 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 983545003515 NAD binding site [chemical binding]; other site 983545003516 homodimer interface [polypeptide binding]; other site 983545003517 active site 983545003518 substrate binding site [chemical binding]; other site 983545003519 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 983545003520 POT family; Region: PTR2; cl17359 983545003521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003522 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545003523 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 983545003524 SLBB domain; Region: SLBB; pfam10531 983545003525 SLBB domain; Region: SLBB; pfam10531 983545003526 SLBB domain; Region: SLBB; pfam10531 983545003527 Chain length determinant protein; Region: Wzz; pfam02706 983545003528 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 983545003529 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545003530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545003531 NAD(P) binding site [chemical binding]; other site 983545003532 homodimer interface [polypeptide binding]; other site 983545003533 substrate binding site [chemical binding]; other site 983545003534 active site 983545003535 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 983545003536 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545003537 inhibitor-cofactor binding pocket; inhibition site 983545003538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545003539 catalytic residue [active] 983545003540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003541 active site 983545003542 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 983545003543 NeuB family; Region: NeuB; pfam03102 983545003544 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 983545003545 NeuB binding interface [polypeptide binding]; other site 983545003546 putative substrate binding site [chemical binding]; other site 983545003547 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003548 ligand binding site; other site 983545003549 tetramer interface; other site 983545003550 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 983545003551 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 983545003552 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 983545003553 Substrate binding site; other site 983545003554 metal-binding site 983545003555 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003556 active site 983545003557 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983545003558 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 983545003559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545003560 active site 983545003561 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 983545003562 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 983545003563 Mg++ binding site [ion binding]; other site 983545003564 putative catalytic motif [active] 983545003565 substrate binding site [chemical binding]; other site 983545003566 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 983545003567 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 983545003568 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 983545003569 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 983545003570 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 983545003571 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 983545003572 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 983545003573 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 983545003574 active site 983545003575 tetramer interface; other site 983545003576 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 983545003577 tartrate dehydrogenase; Region: TTC; TIGR02089 983545003578 isocitrate dehydrogenase; Provisional; Region: PRK08997 983545003579 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 983545003580 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 983545003581 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 983545003582 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 983545003583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 983545003584 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 983545003585 SecY interacting protein Syd; Provisional; Region: PRK04968 983545003586 hypothetical protein; Provisional; Region: PRK11239 983545003587 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 983545003588 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 983545003589 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 983545003590 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 983545003591 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 983545003592 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 983545003593 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 983545003594 probable active site [active] 983545003595 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 983545003596 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545003597 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 983545003598 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545003599 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 983545003600 Peptidase family M28; Region: Peptidase_M28; pfam04389 983545003601 metal binding site [ion binding]; metal-binding site 983545003602 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 983545003603 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 983545003604 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 983545003605 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 983545003606 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 983545003607 active site 983545003608 Riboflavin kinase; Region: Flavokinase; smart00904 983545003609 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 983545003610 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545003611 active site 983545003612 HIGH motif; other site 983545003613 nucleotide binding site [chemical binding]; other site 983545003614 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 983545003615 active site 983545003616 KMSKS motif; other site 983545003617 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 983545003618 tRNA binding surface [nucleotide binding]; other site 983545003619 anticodon binding site; other site 983545003620 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 983545003621 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 983545003622 lipoprotein signal peptidase; Provisional; Region: PRK14787 983545003623 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 983545003624 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983545003625 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 983545003626 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 983545003627 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 983545003628 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 983545003629 PilX N-terminal; Region: PilX_N; pfam14341 983545003630 von Willebrand factor type A domain; Region: VWA_2; pfam13519 983545003631 von Willebrand factor type A domain; Region: VWA_2; pfam13519 983545003632 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 983545003633 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 983545003634 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 983545003635 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 983545003636 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545003637 Type II transport protein GspH; Region: GspH; pfam12019 983545003638 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 983545003639 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 983545003640 hypothetical protein; Provisional; Region: PRK10506 983545003641 hypothetical protein; Provisional; Region: PRK10557 983545003642 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 983545003643 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 983545003644 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 983545003645 homodimer interface [polypeptide binding]; other site 983545003646 NAD binding pocket [chemical binding]; other site 983545003647 ATP binding pocket [chemical binding]; other site 983545003648 Mg binding site [ion binding]; other site 983545003649 active-site loop [active] 983545003650 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 983545003651 Nitrogen regulatory protein P-II; Region: P-II; smart00938 983545003652 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 983545003653 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983545003654 putative global regulator; Reviewed; Region: PRK09559 983545003655 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 983545003656 Uncharacterized conserved protein [Function unknown]; Region: COG2938 983545003657 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545003658 active site 1 [active] 983545003659 L-aspartate oxidase; Provisional; Region: PRK09077 983545003660 L-aspartate oxidase; Provisional; Region: PRK06175 983545003661 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 983545003662 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 983545003663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545003664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545003665 DNA binding residues [nucleotide binding] 983545003666 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 983545003667 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 983545003668 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 983545003669 MucB/RseB family; Region: MucB_RseB; pfam03888 983545003670 anti-sigma E factor; Provisional; Region: rseB; PRK09455 983545003671 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 983545003672 GTP-binding protein LepA; Provisional; Region: PRK05433 983545003673 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 983545003674 G1 box; other site 983545003675 putative GEF interaction site [polypeptide binding]; other site 983545003676 GTP/Mg2+ binding site [chemical binding]; other site 983545003677 Switch I region; other site 983545003678 G2 box; other site 983545003679 G3 box; other site 983545003680 Switch II region; other site 983545003681 G4 box; other site 983545003682 G5 box; other site 983545003683 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 983545003684 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 983545003685 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 983545003686 signal peptidase I; Provisional; Region: PRK10861 983545003687 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545003688 Catalytic site [active] 983545003689 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545003690 ribonuclease III; Reviewed; Region: rnc; PRK00102 983545003691 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 983545003692 dimerization interface [polypeptide binding]; other site 983545003693 active site 983545003694 metal binding site [ion binding]; metal-binding site 983545003695 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 983545003696 dsRNA binding site [nucleotide binding]; other site 983545003697 GTPase Era; Reviewed; Region: era; PRK00089 983545003698 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 983545003699 G1 box; other site 983545003700 GTP/Mg2+ binding site [chemical binding]; other site 983545003701 Switch I region; other site 983545003702 G2 box; other site 983545003703 Switch II region; other site 983545003704 G3 box; other site 983545003705 G4 box; other site 983545003706 G5 box; other site 983545003707 KH domain; Region: KH_2; pfam07650 983545003708 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 983545003709 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 983545003710 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 983545003711 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545003712 active site 983545003713 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 983545003714 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 983545003715 Walker A/P-loop; other site 983545003716 ATP binding site [chemical binding]; other site 983545003717 Q-loop/lid; other site 983545003718 ABC transporter signature motif; other site 983545003719 Walker B; other site 983545003720 D-loop; other site 983545003721 H-loop/switch region; other site 983545003722 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 983545003723 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 983545003724 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 983545003725 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 983545003726 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 983545003727 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 983545003728 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 983545003729 homodimer interface [polypeptide binding]; other site 983545003730 NADP binding site [chemical binding]; other site 983545003731 substrate binding site [chemical binding]; other site 983545003732 trigger factor; Provisional; Region: tig; PRK01490 983545003733 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983545003734 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 983545003735 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 983545003736 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 983545003737 oligomer interface [polypeptide binding]; other site 983545003738 active site residues [active] 983545003739 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 983545003740 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 983545003741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003742 Walker A motif; other site 983545003743 ATP binding site [chemical binding]; other site 983545003744 Walker B motif; other site 983545003745 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 983545003746 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 983545003747 Found in ATP-dependent protease La (LON); Region: LON; smart00464 983545003748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003749 Walker A motif; other site 983545003750 ATP binding site [chemical binding]; other site 983545003751 Walker B motif; other site 983545003752 arginine finger; other site 983545003753 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 983545003754 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983545003755 IHF dimer interface [polypeptide binding]; other site 983545003756 IHF - DNA interface [nucleotide binding]; other site 983545003757 periplasmic folding chaperone; Provisional; Region: PRK10788 983545003758 SurA N-terminal domain; Region: SurA_N_3; cl07813 983545003759 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 983545003760 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 983545003761 active site 983545003762 multimer interface [polypeptide binding]; other site 983545003763 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 983545003764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545003765 FeS/SAM binding site; other site 983545003766 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 983545003767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545003768 binding surface 983545003769 TPR motif; other site 983545003770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545003771 TPR motif; other site 983545003772 binding surface 983545003773 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545003774 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983545003775 cytoskeletal protein RodZ; Provisional; Region: PRK10856 983545003776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545003777 non-specific DNA binding site [nucleotide binding]; other site 983545003778 salt bridge; other site 983545003779 sequence-specific DNA binding site [nucleotide binding]; other site 983545003780 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 983545003781 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 983545003782 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 983545003783 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 983545003784 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 983545003785 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 983545003786 dimer interface [polypeptide binding]; other site 983545003787 motif 1; other site 983545003788 active site 983545003789 motif 2; other site 983545003790 motif 3; other site 983545003791 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 983545003792 anticodon binding site; other site 983545003793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 983545003794 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 983545003795 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 983545003796 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 983545003797 Trp docking motif [polypeptide binding]; other site 983545003798 active site 983545003799 GTP-binding protein Der; Reviewed; Region: PRK00093 983545003800 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 983545003801 G1 box; other site 983545003802 GTP/Mg2+ binding site [chemical binding]; other site 983545003803 Switch I region; other site 983545003804 G2 box; other site 983545003805 Switch II region; other site 983545003806 G3 box; other site 983545003807 G4 box; other site 983545003808 G5 box; other site 983545003809 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 983545003810 G1 box; other site 983545003811 GTP/Mg2+ binding site [chemical binding]; other site 983545003812 Switch I region; other site 983545003813 G2 box; other site 983545003814 G3 box; other site 983545003815 Switch II region; other site 983545003816 G4 box; other site 983545003817 G5 box; other site 983545003818 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 983545003819 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 983545003820 generic binding surface II; other site 983545003821 generic binding surface I; other site 983545003822 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 983545003823 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 983545003824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 983545003825 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 983545003826 active site 983545003827 GMP synthase; Reviewed; Region: guaA; PRK00074 983545003828 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 983545003829 AMP/PPi binding site [chemical binding]; other site 983545003830 candidate oxyanion hole; other site 983545003831 catalytic triad [active] 983545003832 potential glutamine specificity residues [chemical binding]; other site 983545003833 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 983545003834 ATP Binding subdomain [chemical binding]; other site 983545003835 Ligand Binding sites [chemical binding]; other site 983545003836 Dimerization subdomain; other site 983545003837 YaeQ protein; Region: YaeQ; pfam07152 983545003838 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 983545003839 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983545003840 putative acyl-acceptor binding pocket; other site 983545003841 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 983545003842 nucleoside/Zn binding site; other site 983545003843 dimer interface [polypeptide binding]; other site 983545003844 catalytic motif [active] 983545003845 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 983545003846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545003847 substrate binding pocket [chemical binding]; other site 983545003848 membrane-bound complex binding site; other site 983545003849 hinge residues; other site 983545003850 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983545003851 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545003852 catalytic residue [active] 983545003853 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 983545003854 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 983545003855 dimerization interface [polypeptide binding]; other site 983545003856 ATP binding site [chemical binding]; other site 983545003857 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 983545003858 dimerization interface [polypeptide binding]; other site 983545003859 ATP binding site [chemical binding]; other site 983545003860 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 983545003861 putative active site [active] 983545003862 catalytic triad [active] 983545003863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 983545003864 Smr domain; Region: Smr; pfam01713 983545003865 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 983545003866 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 983545003867 active site 983545003868 Zn binding site [ion binding]; other site 983545003869 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 983545003870 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545003871 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 983545003872 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545003873 N-terminal plug; other site 983545003874 ligand-binding site [chemical binding]; other site 983545003875 LPP20 lipoprotein; Region: LPP20; pfam02169 983545003876 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 983545003877 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 983545003878 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 983545003879 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 983545003880 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545003881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545003882 active site 983545003883 phosphorylation site [posttranslational modification] 983545003884 intermolecular recognition site; other site 983545003885 dimerization interface [polypeptide binding]; other site 983545003886 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 983545003887 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 983545003888 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 983545003889 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 983545003890 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 983545003891 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 983545003892 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 983545003893 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 983545003894 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 983545003895 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 983545003896 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 983545003897 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 983545003898 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 983545003899 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 983545003900 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 983545003901 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 983545003902 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 983545003903 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 983545003904 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 983545003905 Flagellar L-ring protein; Region: FlgH; pfam02107 983545003906 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 983545003907 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 983545003908 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 983545003909 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 983545003910 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 983545003911 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 983545003912 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 983545003913 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 983545003914 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003915 flagellin; Provisional; Region: PRK12802 983545003916 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003917 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003918 flagellin; Provisional; Region: PRK12802 983545003919 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003920 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003921 flagellin; Provisional; Region: PRK12802 983545003922 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003923 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003924 FlaG protein; Region: FlaG; pfam03646 983545003925 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 983545003926 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 983545003927 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 983545003928 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 983545003929 Flagellar protein FliS; Region: FliS; cl00654 983545003930 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 983545003931 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545003932 NAD(P) binding site [chemical binding]; other site 983545003933 homodimer interface [polypeptide binding]; other site 983545003934 substrate binding site [chemical binding]; other site 983545003935 active site 983545003936 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983545003937 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545003938 inhibitor-cofactor binding pocket; inhibition site 983545003939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545003940 catalytic residue [active] 983545003941 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003942 ligand binding site; other site 983545003943 tetramer interface; other site 983545003944 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545003945 pseudaminic acid synthase; Region: PseI; TIGR03586 983545003946 NeuB family; Region: NeuB; pfam03102 983545003947 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 983545003948 NeuB binding interface [polypeptide binding]; other site 983545003949 putative substrate binding site [chemical binding]; other site 983545003950 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 983545003951 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545003952 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 983545003953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983545003954 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 983545003955 AMP binding site [chemical binding]; other site 983545003956 active site 983545003957 acyl-activating enzyme (AAE) consensus motif; other site 983545003958 CoA binding site [chemical binding]; other site 983545003959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003960 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545003961 NAD(P) binding site [chemical binding]; other site 983545003962 active site 983545003963 LicD family; Region: LicD; pfam04991 983545003964 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545003965 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 983545003966 active site 983545003967 nucleotide binding site [chemical binding]; other site 983545003968 HIGH motif; other site 983545003969 KMSKS motif; other site 983545003970 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 983545003971 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 983545003972 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983545003973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003974 active site 983545003975 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 983545003976 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 983545003977 Methyltransferase domain; Region: Methyltransf_23; pfam13489 983545003978 Methyltransferase domain; Region: Methyltransf_12; pfam08242 983545003979 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003980 ligand binding site; other site 983545003981 tetramer interface; other site 983545003982 Methyltransferase domain; Region: Methyltransf_24; pfam13578 983545003983 FOG: CBS domain [General function prediction only]; Region: COG0517 983545003984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 983545003985 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 983545003986 NeuB family; Region: NeuB; pfam03102 983545003987 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 983545003988 NeuB binding interface [polypeptide binding]; other site 983545003989 putative substrate binding site [chemical binding]; other site 983545003990 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 983545003991 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 983545003992 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003993 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545003994 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 983545003995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545003996 Walker A motif; other site 983545003997 ATP binding site [chemical binding]; other site 983545003998 Walker B motif; other site 983545003999 arginine finger; other site 983545004000 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 983545004001 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 983545004002 PAS domain; Region: PAS; smart00091 983545004003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545004004 dimer interface [polypeptide binding]; other site 983545004005 phosphorylation site [posttranslational modification] 983545004006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545004007 ATP binding site [chemical binding]; other site 983545004008 Mg2+ binding site [ion binding]; other site 983545004009 G-X-G motif; other site 983545004010 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545004011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545004012 active site 983545004013 phosphorylation site [posttranslational modification] 983545004014 intermolecular recognition site; other site 983545004015 dimerization interface [polypeptide binding]; other site 983545004016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545004017 Walker A motif; other site 983545004018 ATP binding site [chemical binding]; other site 983545004019 Walker B motif; other site 983545004020 arginine finger; other site 983545004021 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 983545004022 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 983545004023 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 983545004024 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 983545004025 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 983545004026 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 983545004027 MgtE intracellular N domain; Region: MgtE_N; smart00924 983545004028 FliG C-terminal domain; Region: FliG_C; pfam01706 983545004029 flagellar assembly protein H; Validated; Region: fliH; PRK05687 983545004030 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 983545004031 Flagellar assembly protein FliH; Region: FliH; pfam02108 983545004032 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 983545004033 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 983545004034 Walker A motif/ATP binding site; other site 983545004035 Walker B motif; other site 983545004036 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 983545004037 Flagellar FliJ protein; Region: FliJ; pfam02050 983545004038 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 983545004039 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 983545004040 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 983545004041 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 983545004042 flagellar motor switch protein; Validated; Region: fliN; PRK08983 983545004043 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 983545004044 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 983545004045 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 983545004046 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 983545004047 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 983545004048 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 983545004049 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 983545004050 FHIPEP family; Region: FHIPEP; pfam00771 983545004051 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 983545004052 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 983545004053 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 983545004054 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 983545004055 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 983545004056 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 983545004057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545004058 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983545004059 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545004060 DNA binding residues [nucleotide binding] 983545004061 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 983545004062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545004063 active site 983545004064 phosphorylation site [posttranslational modification] 983545004065 intermolecular recognition site; other site 983545004066 dimerization interface [polypeptide binding]; other site 983545004067 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 983545004068 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545004069 putative binding surface; other site 983545004070 active site 983545004071 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 983545004072 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 983545004073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545004074 ATP binding site [chemical binding]; other site 983545004075 Mg2+ binding site [ion binding]; other site 983545004076 G-X-G motif; other site 983545004077 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 983545004078 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 983545004079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545004080 active site 983545004081 phosphorylation site [posttranslational modification] 983545004082 intermolecular recognition site; other site 983545004083 dimerization interface [polypeptide binding]; other site 983545004084 CheB methylesterase; Region: CheB_methylest; pfam01339 983545004085 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 983545004086 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 983545004087 Magnesium ion binding site [ion binding]; other site 983545004088 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 983545004089 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 983545004090 putative CheA interaction surface; other site 983545004091 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 983545004092 homoserine O-succinyltransferase; Provisional; Region: PRK05368 983545004093 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 983545004094 proposed active site lysine [active] 983545004095 conserved cys residue [active] 983545004096 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 983545004097 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 983545004098 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 983545004099 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 983545004100 substrate binding pocket [chemical binding]; other site 983545004101 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 983545004102 B12 binding site [chemical binding]; other site 983545004103 cobalt ligand [ion binding]; other site 983545004104 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 983545004105 Protein of unknown function (DUF938); Region: DUF938; pfam06080 983545004106 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 983545004107 Protein of unknown function, DUF482; Region: DUF482; pfam04339 983545004108 recombination regulator RecX; Reviewed; Region: recX; PRK00117 983545004109 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 983545004110 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 983545004111 motif 1; other site 983545004112 active site 983545004113 motif 2; other site 983545004114 motif 3; other site 983545004115 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 983545004116 DHHA1 domain; Region: DHHA1; pfam02272 983545004117 carbon storage regulator; Provisional; Region: PRK01712 983545004118 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 983545004119 oxaloacetate decarboxylase; Provisional; Region: PRK14040 983545004120 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 983545004121 active site 983545004122 catalytic residues [active] 983545004123 metal binding site [ion binding]; metal-binding site 983545004124 homodimer binding site [polypeptide binding]; other site 983545004125 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545004126 carboxyltransferase (CT) interaction site; other site 983545004127 biotinylation site [posttranslational modification]; other site 983545004128 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 983545004129 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 983545004130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 983545004131 Walker A/P-loop; other site 983545004132 ATP binding site [chemical binding]; other site 983545004133 Q-loop/lid; other site 983545004134 ABC transporter signature motif; other site 983545004135 Walker B; other site 983545004136 D-loop; other site 983545004137 H-loop/switch region; other site 983545004138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 983545004139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 983545004140 Walker A/P-loop; other site 983545004141 ATP binding site [chemical binding]; other site 983545004142 Q-loop/lid; other site 983545004143 ABC transporter signature motif; other site 983545004144 Walker B; other site 983545004145 D-loop; other site 983545004146 H-loop/switch region; other site 983545004147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 983545004148 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 983545004149 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 983545004150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545004151 dimer interface [polypeptide binding]; other site 983545004152 conserved gate region; other site 983545004153 putative PBP binding loops; other site 983545004154 ABC-ATPase subunit interface; other site 983545004155 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 983545004156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545004157 dimer interface [polypeptide binding]; other site 983545004158 conserved gate region; other site 983545004159 putative PBP binding loops; other site 983545004160 ABC-ATPase subunit interface; other site 983545004161 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 983545004162 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 983545004163 peptide binding site [polypeptide binding]; other site 983545004164 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 983545004165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545004166 Walker A motif; other site 983545004167 ATP binding site [chemical binding]; other site 983545004168 Walker B motif; other site 983545004169 arginine finger; other site 983545004170 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 983545004171 phage shock protein A; Region: phageshock_pspA; TIGR02977 983545004172 phage shock protein B; Provisional; Region: pspB; PRK09458 983545004173 phage shock protein C; Region: phageshock_pspC; TIGR02978 983545004174 PspC domain; Region: PspC; pfam04024 983545004175 YcjX-like family, DUF463; Region: DUF463; pfam04317 983545004176 hypothetical protein; Provisional; Region: PRK05415 983545004177 Domain of unknown function (DUF697); Region: DUF697; pfam05128 983545004178 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 983545004179 cofactor binding site; other site 983545004180 metal binding site [ion binding]; metal-binding site 983545004181 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 983545004182 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 983545004183 putative aromatic amino acid binding site; other site 983545004184 PAS domain; Region: PAS; smart00091 983545004185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545004186 Walker A motif; other site 983545004187 ATP binding site [chemical binding]; other site 983545004188 Walker B motif; other site 983545004189 arginine finger; other site 983545004190 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 983545004191 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 983545004192 dimer interface [polypeptide binding]; other site 983545004193 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 983545004194 active site 983545004195 Fe binding site [ion binding]; other site 983545004196 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545004197 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 983545004198 putative DNA binding site [nucleotide binding]; other site 983545004199 putative Zn2+ binding site [ion binding]; other site 983545004200 AsnC family; Region: AsnC_trans_reg; pfam01037 983545004201 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 983545004202 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983545004203 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 983545004204 NAD binding site [chemical binding]; other site 983545004205 Phe binding site; other site 983545004206 Late competence development protein ComFB; Region: ComFB; pfam10719 983545004207 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545004208 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545004209 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545004210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004211 binding surface 983545004212 TPR motif; other site 983545004213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004214 binding surface 983545004215 TPR motif; other site 983545004216 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983545004217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545004218 binding surface 983545004219 TPR motif; other site 983545004220 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 983545004221 Methyltransferase domain; Region: Methyltransf_31; pfam13847 983545004222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545004223 S-adenosylmethionine binding site [chemical binding]; other site 983545004224 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 983545004225 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 983545004226 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 983545004227 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 983545004228 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 983545004229 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 983545004230 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 983545004231 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 983545004232 TPR repeat; Region: TPR_11; pfam13414 983545004233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004234 binding surface 983545004235 TPR motif; other site 983545004236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004237 binding surface 983545004238 TPR repeat; Region: TPR_11; pfam13414 983545004239 TPR motif; other site 983545004240 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 983545004241 nucleotide binding site [chemical binding]; other site 983545004242 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 983545004243 putative NEF/HSP70 interaction site [polypeptide binding]; other site 983545004244 nucleotide binding site [chemical binding]; other site 983545004245 SBD interface [polypeptide binding]; other site 983545004246 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 983545004247 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545004248 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 983545004249 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545004250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004251 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545004252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004253 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 983545004254 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545004255 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545004256 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004257 catalytic residue [active] 983545004258 endonuclease III; Provisional; Region: PRK10702 983545004259 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 983545004260 minor groove reading motif; other site 983545004261 helix-hairpin-helix signature motif; other site 983545004262 substrate binding pocket [chemical binding]; other site 983545004263 active site 983545004264 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 983545004265 electron transport complex RsxE subunit; Provisional; Region: PRK12405 983545004266 FMN-binding domain; Region: FMN_bind; cl01081 983545004267 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 983545004268 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 983545004269 SLBB domain; Region: SLBB; pfam10531 983545004270 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 983545004271 electron transport complex protein RnfB; Provisional; Region: PRK05113 983545004272 Putative Fe-S cluster; Region: FeS; pfam04060 983545004273 4Fe-4S binding domain; Region: Fer4; pfam00037 983545004274 electron transport complex protein RsxA; Provisional; Region: PRK05151 983545004275 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149 983545004276 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 983545004277 excinuclease ABC subunit B; Provisional; Region: PRK05298 983545004278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545004279 ATP binding site [chemical binding]; other site 983545004280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545004281 nucleotide binding region [chemical binding]; other site 983545004282 ATP-binding site [chemical binding]; other site 983545004283 Ultra-violet resistance protein B; Region: UvrB; pfam12344 983545004284 UvrB/uvrC motif; Region: UVR; pfam02151 983545004285 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545004287 LysR substrate binding domain; Region: LysR_substrate; pfam03466 983545004288 dimerization interface [polypeptide binding]; other site 983545004289 MASE1; Region: MASE1; cl17823 983545004290 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 983545004291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545004292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545004293 dimer interface [polypeptide binding]; other site 983545004294 phosphorylation site [posttranslational modification] 983545004295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545004296 ATP binding site [chemical binding]; other site 983545004297 Mg2+ binding site [ion binding]; other site 983545004298 G-X-G motif; other site 983545004299 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545004300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545004301 active site 983545004302 phosphorylation site [posttranslational modification] 983545004303 intermolecular recognition site; other site 983545004304 dimerization interface [polypeptide binding]; other site 983545004305 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 983545004306 Ligand Binding Site [chemical binding]; other site 983545004307 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 983545004308 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 983545004309 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 983545004310 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 983545004311 NADP binding site [chemical binding]; other site 983545004312 dimer interface [polypeptide binding]; other site 983545004313 hypothetical protein; Provisional; Region: PRK06194 983545004314 classical (c) SDRs; Region: SDR_c; cd05233 983545004315 NAD(P) binding site [chemical binding]; other site 983545004316 active site 983545004317 asparagine synthetase B; Provisional; Region: asnB; PRK09431 983545004318 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545004319 active site 983545004320 dimer interface [polypeptide binding]; other site 983545004321 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983545004322 Ligand Binding Site [chemical binding]; other site 983545004323 Molecular Tunnel; other site 983545004324 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 983545004325 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 983545004326 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545004327 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 983545004328 Peptidase family M28; Region: Peptidase_M28; pfam04389 983545004329 metal binding site [ion binding]; metal-binding site 983545004330 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 983545004331 Yip1 domain; Region: Yip1; pfam04893 983545004332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545004333 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 983545004334 Walker A/P-loop; other site 983545004335 ATP binding site [chemical binding]; other site 983545004336 Q-loop/lid; other site 983545004337 ABC transporter signature motif; other site 983545004338 Walker B; other site 983545004339 D-loop; other site 983545004340 H-loop/switch region; other site 983545004341 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 983545004342 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 983545004343 Protein of unknown function DUF72; Region: DUF72; cl00777 983545004344 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 983545004345 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 983545004346 dimer interface [polypeptide binding]; other site 983545004347 anticodon binding site; other site 983545004348 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 983545004349 homodimer interface [polypeptide binding]; other site 983545004350 motif 1; other site 983545004351 active site 983545004352 motif 2; other site 983545004353 GAD domain; Region: GAD; pfam02938 983545004354 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983545004355 active site 983545004356 motif 3; other site 983545004357 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 983545004358 nudix motif; other site 983545004359 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 983545004360 active site 983545004361 putative DNA-binding cleft [nucleotide binding]; other site 983545004362 dimer interface [polypeptide binding]; other site 983545004363 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 983545004364 RuvA N terminal domain; Region: RuvA_N; pfam01330 983545004365 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 983545004366 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 983545004367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545004368 Walker A motif; other site 983545004369 ATP binding site [chemical binding]; other site 983545004370 Walker B motif; other site 983545004371 arginine finger; other site 983545004372 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 983545004373 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545004374 active site 983545004375 TolQ protein; Region: tolQ; TIGR02796 983545004376 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 983545004377 TolR protein; Region: tolR; TIGR02801 983545004378 TolA protein; Region: tolA_full; TIGR02794 983545004379 TolA C-terminal; Region: TolA; pfam06519 983545004380 translocation protein TolB; Provisional; Region: tolB; PRK04792 983545004381 TolB amino-terminal domain; Region: TolB_N; pfam04052 983545004382 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545004383 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545004384 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545004385 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 983545004386 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545004387 ligand binding site [chemical binding]; other site 983545004388 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 983545004389 Tetratricopeptide repeat; Region: TPR_6; pfam13174 983545004390 Tetratricopeptide repeat; Region: TPR_6; pfam13174 983545004391 HDOD domain; Region: HDOD; pfam08668 983545004392 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 983545004393 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 983545004394 active site 983545004395 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545004396 active site 2 [active] 983545004397 active site 1 [active] 983545004398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545004399 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545004400 putative substrate translocation pore; other site 983545004401 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545004402 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 983545004403 catalytic site [active] 983545004404 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 983545004405 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 983545004406 ligand binding site; other site 983545004407 oligomer interface; other site 983545004408 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 983545004409 dimer interface [polypeptide binding]; other site 983545004410 N-terminal domain interface [polypeptide binding]; other site 983545004411 sulfate 1 binding site; other site 983545004412 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 983545004413 putative hydrophobic ligand binding site [chemical binding]; other site 983545004414 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 983545004415 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 983545004416 active site 983545004417 catalytic residues [active] 983545004418 metal binding site [ion binding]; metal-binding site 983545004419 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 983545004420 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545004421 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983545004422 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 983545004423 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545004424 carboxyltransferase (CT) interaction site; other site 983545004425 biotinylation site [posttranslational modification]; other site 983545004426 enoyl-CoA hydratase; Provisional; Region: PRK05995 983545004427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545004428 substrate binding site [chemical binding]; other site 983545004429 oxyanion hole (OAH) forming residues; other site 983545004430 trimer interface [polypeptide binding]; other site 983545004431 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 983545004432 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 983545004433 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 983545004434 isovaleryl-CoA dehydrogenase; Region: PLN02519 983545004435 substrate binding site [chemical binding]; other site 983545004436 FAD binding site [chemical binding]; other site 983545004437 catalytic base [active] 983545004438 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 983545004439 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 983545004440 DNA binding residues [nucleotide binding] 983545004441 putative dimer interface [polypeptide binding]; other site 983545004442 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 983545004443 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545004444 dimer interface [polypeptide binding]; other site 983545004445 active site 983545004446 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545004447 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545004448 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545004449 kynureninase; Region: kynureninase; TIGR01814 983545004450 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004451 catalytic residue [active] 983545004452 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545004453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545004454 active site 983545004455 phosphorylation site [posttranslational modification] 983545004456 intermolecular recognition site; other site 983545004457 dimerization interface [polypeptide binding]; other site 983545004458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545004459 binding surface 983545004460 TPR motif; other site 983545004461 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 983545004462 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 983545004463 HIGH motif; other site 983545004464 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 983545004465 active site 983545004466 KMSKS motif; other site 983545004467 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 983545004468 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 983545004469 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 983545004470 FMN binding site [chemical binding]; other site 983545004471 active site 983545004472 catalytic residues [active] 983545004473 substrate binding site [chemical binding]; other site 983545004474 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 983545004475 active site 983545004476 catalytic triad [active] 983545004477 oxyanion hole [active] 983545004478 switch loop; other site 983545004479 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 983545004480 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983545004481 Walker A/P-loop; other site 983545004482 ATP binding site [chemical binding]; other site 983545004483 Q-loop/lid; other site 983545004484 ABC transporter signature motif; other site 983545004485 Walker B; other site 983545004486 D-loop; other site 983545004487 H-loop/switch region; other site 983545004488 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 983545004489 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545004490 FtsX-like permease family; Region: FtsX; pfam02687 983545004491 FtsX-like permease family; Region: FtsX; pfam02687 983545004492 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 983545004493 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 983545004494 putative NAD(P) binding site [chemical binding]; other site 983545004495 putative active site [active] 983545004496 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 983545004497 active site 983545004498 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 983545004499 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983545004500 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 983545004501 putative NAD(P) binding site [chemical binding]; other site 983545004502 homodimer interface [polypeptide binding]; other site 983545004503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545004505 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545004506 putative effector binding pocket; other site 983545004507 dimerization interface [polypeptide binding]; other site 983545004508 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545004509 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004510 metal binding site [ion binding]; metal-binding site 983545004511 active site 983545004512 I-site; other site 983545004513 hypothetical protein; Provisional; Region: PRK05409 983545004514 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 983545004515 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545004516 active site 983545004517 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 983545004518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545004519 Walker A motif; other site 983545004520 ATP binding site [chemical binding]; other site 983545004521 Walker B motif; other site 983545004522 DNA polymerase III subunit delta'; Validated; Region: PRK08485 983545004523 arginine finger; other site 983545004524 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 983545004525 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 983545004526 hypothetical protein; Validated; Region: PRK00153 983545004527 recombination protein RecR; Reviewed; Region: recR; PRK00076 983545004528 RecR protein; Region: RecR; pfam02132 983545004529 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 983545004530 putative active site [active] 983545004531 putative metal-binding site [ion binding]; other site 983545004532 tetramer interface [polypeptide binding]; other site 983545004533 heat shock protein 90; Provisional; Region: PRK05218 983545004534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545004535 ATP binding site [chemical binding]; other site 983545004536 Mg2+ binding site [ion binding]; other site 983545004537 G-X-G motif; other site 983545004538 adenylate kinase; Reviewed; Region: adk; PRK00279 983545004539 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 983545004540 AMP-binding site [chemical binding]; other site 983545004541 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 983545004542 MAPEG family; Region: MAPEG; cl09190 983545004543 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 983545004544 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 983545004545 putative dimer interface [polypeptide binding]; other site 983545004546 hypothetical protein; Provisional; Region: PRK03757 983545004547 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 983545004548 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 983545004549 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 983545004550 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 983545004551 metal binding site [ion binding]; metal-binding site 983545004552 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 983545004553 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 983545004554 substrate binding site [chemical binding]; other site 983545004555 glutamase interaction surface [polypeptide binding]; other site 983545004556 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 983545004557 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 983545004558 homodimer interface [polypeptide binding]; other site 983545004559 substrate-cofactor binding pocket; other site 983545004560 catalytic residue [active] 983545004561 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 983545004562 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 983545004563 catalytic residues [active] 983545004564 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 983545004565 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 983545004566 putative active site [active] 983545004567 oxyanion strand; other site 983545004568 catalytic triad [active] 983545004569 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 983545004570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545004571 active site 983545004572 motif I; other site 983545004573 motif II; other site 983545004574 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 983545004575 putative active site pocket [active] 983545004576 4-fold oligomerization interface [polypeptide binding]; other site 983545004577 metal binding residues [ion binding]; metal-binding site 983545004578 3-fold/trimer interface [polypeptide binding]; other site 983545004579 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 983545004580 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545004581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545004582 homodimer interface [polypeptide binding]; other site 983545004583 catalytic residue [active] 983545004584 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 983545004585 histidinol dehydrogenase; Region: hisD; TIGR00069 983545004586 NAD binding site [chemical binding]; other site 983545004587 dimerization interface [polypeptide binding]; other site 983545004588 product binding site; other site 983545004589 substrate binding site [chemical binding]; other site 983545004590 zinc binding site [ion binding]; other site 983545004591 catalytic residues [active] 983545004592 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 983545004593 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 983545004594 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 983545004595 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545004596 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545004597 active site 983545004598 catalytic tetrad [active] 983545004599 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 983545004600 Predicted membrane protein [Function unknown]; Region: COG2855 983545004601 sulfite oxidase; Provisional; Region: PLN00177 983545004602 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 983545004603 Moco binding site; other site 983545004604 metal coordination site [ion binding]; other site 983545004605 dimerization interface [polypeptide binding]; other site 983545004606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545004607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545004608 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545004609 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545004610 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545004611 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545004612 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545004613 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545004614 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545004615 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545004616 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545004617 DNA binding residues [nucleotide binding] 983545004618 dimer interface [polypeptide binding]; other site 983545004619 putative metal binding site [ion binding]; other site 983545004620 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 983545004621 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545004622 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545004623 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545004624 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 983545004625 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 983545004626 DctM-like transporters; Region: DctM; pfam06808 983545004627 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 983545004628 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 983545004629 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 983545004630 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 983545004631 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 983545004632 active site 983545004633 homotrimer interface [polypeptide binding]; other site 983545004634 catalytic site [active] 983545004635 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 983545004636 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 983545004637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545004638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004639 metal binding site [ion binding]; metal-binding site 983545004640 active site 983545004641 I-site; other site 983545004642 HDOD domain; Region: HDOD; pfam08668 983545004643 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545004644 Zn2+ binding site [ion binding]; other site 983545004645 Mg2+ binding site [ion binding]; other site 983545004646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 983545004647 ACT domain; Region: ACT_3; pfam10000 983545004648 Family description; Region: ACT_7; pfam13840 983545004649 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545004650 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545004651 substrate binding site [chemical binding]; other site 983545004652 oxyanion hole (OAH) forming residues; other site 983545004653 trimer interface [polypeptide binding]; other site 983545004654 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983545004655 MarR family; Region: MarR; pfam01047 983545004656 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 983545004657 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 983545004658 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 983545004659 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 983545004660 Cytochrome c; Region: Cytochrom_C; pfam00034 983545004661 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545004662 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 983545004663 D-pathway; other site 983545004664 Putative ubiquinol binding site [chemical binding]; other site 983545004665 Low-spin heme (heme b) binding site [chemical binding]; other site 983545004666 Putative water exit pathway; other site 983545004667 Binuclear center (heme o3/CuB) [ion binding]; other site 983545004668 K-pathway; other site 983545004669 Putative proton exit pathway; other site 983545004670 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 983545004671 Subunit I/III interface [polypeptide binding]; other site 983545004672 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 983545004673 Cytochrome c; Region: Cytochrom_C; cl11414 983545004674 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 983545004675 Family description; Region: VCBS; pfam13517 983545004676 Family description; Region: VCBS; pfam13517 983545004677 Family description; Region: VCBS; pfam13517 983545004678 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 983545004679 Bacterial Ig-like domain 2; Region: BID_2; smart00635 983545004680 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 983545004681 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 983545004682 Family description; Region: VCBS; pfam13517 983545004683 Family description; Region: VCBS; pfam13517 983545004684 Family description; Region: VCBS; pfam13517 983545004685 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 983545004686 Peptidase family M48; Region: Peptidase_M48; cl12018 983545004687 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 983545004688 homotrimer interaction site [polypeptide binding]; other site 983545004689 putative active site [active] 983545004690 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983545004691 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545004692 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004693 catalytic residue [active] 983545004694 2-isopropylmalate synthase; Validated; Region: PRK03739 983545004695 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 983545004696 active site 983545004697 catalytic residues [active] 983545004698 metal binding site [ion binding]; metal-binding site 983545004699 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 983545004700 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545004701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545004702 putative DNA binding site [nucleotide binding]; other site 983545004703 putative Zn2+ binding site [ion binding]; other site 983545004704 AsnC family; Region: AsnC_trans_reg; pfam01037 983545004705 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 983545004706 LysR family transcriptional regulator; Provisional; Region: PRK14997 983545004707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545004708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004709 dimerization interface [polypeptide binding]; other site 983545004710 Pirin-related protein [General function prediction only]; Region: COG1741 983545004711 Pirin; Region: Pirin; pfam02678 983545004712 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 983545004713 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 983545004714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004715 NADH(P)-binding; Region: NAD_binding_10; pfam13460 983545004716 NAD(P) binding site [chemical binding]; other site 983545004717 active site 983545004718 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 983545004719 Cupin; Region: Cupin_6; pfam12852 983545004720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004721 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545004722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004723 Beta-lactamase; Region: Beta-lactamase; pfam00144 983545004724 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545004725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 983545004726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 983545004727 Coenzyme A binding pocket [chemical binding]; other site 983545004728 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 983545004729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545004730 non-specific DNA binding site [nucleotide binding]; other site 983545004731 salt bridge; other site 983545004732 sequence-specific DNA binding site [nucleotide binding]; other site 983545004733 aminotransferase; Validated; Region: PRK07337 983545004734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545004735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545004736 homodimer interface [polypeptide binding]; other site 983545004737 catalytic residue [active] 983545004738 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983545004739 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004740 N-terminal plug; other site 983545004741 ligand-binding site [chemical binding]; other site 983545004742 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 983545004743 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 983545004744 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 983545004745 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 983545004746 intersubunit interface [polypeptide binding]; other site 983545004747 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 983545004748 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 983545004749 ABC-ATPase subunit interface; other site 983545004750 dimer interface [polypeptide binding]; other site 983545004751 putative PBP binding regions; other site 983545004752 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 983545004753 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 983545004754 Walker A/P-loop; other site 983545004755 ATP binding site [chemical binding]; other site 983545004756 Q-loop/lid; other site 983545004757 ABC transporter signature motif; other site 983545004758 Walker B; other site 983545004759 D-loop; other site 983545004760 H-loop/switch region; other site 983545004761 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 983545004762 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 983545004763 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 983545004764 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 983545004765 catalytic residues [active] 983545004766 Ion channel; Region: Ion_trans_2; pfam07885 983545004767 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545004768 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004769 metal binding site [ion binding]; metal-binding site 983545004770 active site 983545004771 I-site; other site 983545004772 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 983545004773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545004774 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 983545004775 Coenzyme A binding pocket [chemical binding]; other site 983545004776 REJ domain; Region: REJ; pfam02010 983545004777 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 983545004778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004779 binding surface 983545004780 TPR motif; other site 983545004781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545004782 binding surface 983545004783 TPR motif; other site 983545004784 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 983545004785 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 983545004786 Predicted amidohydrolase [General function prediction only]; Region: COG0388 983545004787 putative active site [active] 983545004788 catalytic triad [active] 983545004789 putative dimer interface [polypeptide binding]; other site 983545004790 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545004791 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 983545004792 NAD(P) binding site [chemical binding]; other site 983545004793 catalytic residues [active] 983545004794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545004795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545004796 putative substrate translocation pore; other site 983545004797 YciI-like protein; Reviewed; Region: PRK12863 983545004798 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545004799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004800 DNA-binding site [nucleotide binding]; DNA binding site 983545004801 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 983545004802 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 983545004803 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 983545004804 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 983545004805 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983545004806 acyl-activating enzyme (AAE) consensus motif; other site 983545004807 AMP binding site [chemical binding]; other site 983545004808 active site 983545004809 CoA binding site [chemical binding]; other site 983545004810 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 983545004811 Amidase; Region: Amidase; cl11426 983545004812 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545004813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004814 DNA-binding site [nucleotide binding]; DNA binding site 983545004815 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 983545004816 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545004817 FAD binding domain; Region: FAD_binding_4; pfam01565 983545004818 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545004819 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 983545004820 isopropylmalate isomerase large subunit; Provisional; Region: PRK12466 983545004821 substrate binding site [chemical binding]; other site 983545004822 ligand binding site [chemical binding]; other site 983545004823 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 983545004824 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 983545004825 hypothetical protein; Provisional; Region: PRK14812 983545004826 substrate binding site [chemical binding]; other site 983545004827 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 983545004828 CoA-transferase family III; Region: CoA_transf_3; pfam02515 983545004829 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 983545004830 active site 983545004831 catalytic residues [active] 983545004832 metal binding site [ion binding]; metal-binding site 983545004833 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 983545004834 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 983545004835 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545004836 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 983545004837 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545004838 N-terminal domain interface [polypeptide binding]; other site 983545004839 dimer interface [polypeptide binding]; other site 983545004840 substrate binding pocket (H-site) [chemical binding]; other site 983545004841 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545004842 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545004843 NAD(P) binding site [chemical binding]; other site 983545004844 substrate binding site [chemical binding]; other site 983545004845 dimer interface [polypeptide binding]; other site 983545004846 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 983545004847 dockerin binding interface; other site 983545004848 PEP-CTERM motif; Region: VPEP; pfam07589 983545004849 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545004850 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004851 N-terminal plug; other site 983545004852 ligand-binding site [chemical binding]; other site 983545004853 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004854 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 983545004855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545004856 substrate binding site [chemical binding]; other site 983545004857 oxyanion hole (OAH) forming residues; other site 983545004858 trimer interface [polypeptide binding]; other site 983545004859 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545004860 CoenzymeA binding site [chemical binding]; other site 983545004861 subunit interaction site [polypeptide binding]; other site 983545004862 PHB binding site; other site 983545004863 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 983545004864 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 983545004865 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 983545004866 putative active site [active] 983545004867 putative catalytic site [active] 983545004868 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 983545004869 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545004870 putative active site [active] 983545004871 putative catalytic site [active] 983545004872 Isochorismatase family; Region: Isochorismatase; pfam00857 983545004873 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 983545004874 catalytic triad [active] 983545004875 conserved cis-peptide bond; other site 983545004876 Methyltransferase domain; Region: Methyltransf_31; pfam13847 983545004877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545004878 S-adenosylmethionine binding site [chemical binding]; other site 983545004879 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545004880 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545004881 YHYH protein; Region: YHYH; pfam14240 983545004882 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 983545004883 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 983545004884 putative acyl-acceptor binding pocket; other site 983545004885 REDY-like protein HapK; Region: HapK; pfam11639 983545004886 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545004887 classical (c) SDRs; Region: SDR_c; cd05233 983545004888 NAD(P) binding site [chemical binding]; other site 983545004889 active site 983545004890 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545004891 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 983545004892 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 983545004893 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 983545004894 putative active site [active] 983545004895 putative catalytic site [active] 983545004896 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545004897 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545004898 active site 983545004899 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 983545004900 CoA-transferase family III; Region: CoA_transf_3; pfam02515 983545004901 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 983545004902 CoA-transferase family III; Region: CoA_transf_3; pfam02515 983545004903 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 983545004904 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 983545004905 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004906 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004907 N-terminal plug; other site 983545004908 ligand-binding site [chemical binding]; other site 983545004909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983545004910 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 983545004911 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 983545004912 EthD domain; Region: EthD; cl17553 983545004913 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545004914 CoenzymeA binding site [chemical binding]; other site 983545004915 subunit interaction site [polypeptide binding]; other site 983545004916 PHB binding site; other site 983545004917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545004918 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983545004919 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545004920 Predicted ATPase [General function prediction only]; Region: COG1485 983545004921 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004922 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545004923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545004924 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545004925 active site 983545004926 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983545004927 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545004928 ligand binding site [chemical binding]; other site 983545004929 flexible hinge region; other site 983545004930 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 983545004931 putative switch regulator; other site 983545004932 non-specific DNA interactions [nucleotide binding]; other site 983545004933 DNA binding site [nucleotide binding] 983545004934 sequence specific DNA binding site [nucleotide binding]; other site 983545004935 putative cAMP binding site [chemical binding]; other site 983545004936 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545004937 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545004938 active site 983545004939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545004940 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 983545004941 Coenzyme A binding pocket [chemical binding]; other site 983545004942 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545004943 Sulfatase; Region: Sulfatase; pfam00884 983545004944 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545004945 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545004946 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545004947 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545004948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004949 DNA-binding site [nucleotide binding]; DNA binding site 983545004950 FCD domain; Region: FCD; pfam07729 983545004951 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545004952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545004953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004954 DNA binding site [nucleotide binding] 983545004955 domain linker motif; other site 983545004956 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545004957 dimerization interface [polypeptide binding]; other site 983545004958 ligand binding site [chemical binding]; other site 983545004959 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545004960 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 983545004961 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545004962 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 983545004963 AP (apurinic/apyrimidinic) site pocket; other site 983545004964 DNA interaction; other site 983545004965 Metal-binding active site; metal-binding site 983545004966 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 983545004967 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 983545004968 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 983545004969 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 983545004970 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 983545004971 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545004972 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 983545004973 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 983545004974 putative transporter; Provisional; Region: PRK10484 983545004975 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 983545004976 Na binding site [ion binding]; other site 983545004977 substrate binding site [chemical binding]; other site 983545004978 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 983545004979 active site 983545004980 catalytic residues [active] 983545004981 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 983545004982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004983 DNA binding site [nucleotide binding] 983545004984 domain linker motif; other site 983545004985 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545004986 dimerization interface (closed form) [polypeptide binding]; other site 983545004987 ligand binding site [chemical binding]; other site 983545004988 MFS/sugar transport protein; Region: MFS_2; pfam13347 983545004989 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 983545004990 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545004991 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004992 DNA binding site [nucleotide binding] 983545004993 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545004994 dimerization interface (closed form) [polypeptide binding]; other site 983545004995 ligand binding site [chemical binding]; other site 983545004996 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545004997 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545004998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004999 catalytic residue [active] 983545005000 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 983545005001 HAMP domain; Region: HAMP; pfam00672 983545005002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005003 metal binding site [ion binding]; metal-binding site 983545005004 active site 983545005005 I-site; other site 983545005006 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545005007 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 983545005008 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545005009 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545005010 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 983545005011 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 983545005012 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983545005013 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 983545005014 Walker A/P-loop; other site 983545005015 ATP binding site [chemical binding]; other site 983545005016 Q-loop/lid; other site 983545005017 ABC transporter signature motif; other site 983545005018 Walker B; other site 983545005019 D-loop; other site 983545005020 H-loop/switch region; other site 983545005021 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 983545005022 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545005023 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 983545005024 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545005025 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545005026 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 983545005027 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 983545005028 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 983545005029 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545005030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545005031 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 983545005032 dimerization interface [polypeptide binding]; other site 983545005033 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545005034 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545005035 active site 983545005036 metal binding site [ion binding]; metal-binding site 983545005037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545005038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545005039 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545005040 putative effector binding pocket; other site 983545005041 dimerization interface [polypeptide binding]; other site 983545005042 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 983545005043 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 983545005044 potential catalytic triad [active] 983545005045 conserved cys residue [active] 983545005046 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 983545005047 Predicted membrane protein [Function unknown]; Region: COG3235 983545005048 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 983545005049 putative catalytic site [active] 983545005050 putative phosphate binding site [ion binding]; other site 983545005051 active site 983545005052 metal binding site A [ion binding]; metal-binding site 983545005053 DNA binding site [nucleotide binding] 983545005054 putative AP binding site [nucleotide binding]; other site 983545005055 putative metal binding site B [ion binding]; other site 983545005056 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545005057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545005058 DNA-binding site [nucleotide binding]; DNA binding site 983545005059 FCD domain; Region: FCD; pfam07729 983545005060 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 983545005061 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 983545005062 active site pocket [active] 983545005063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005064 D-galactonate transporter; Region: 2A0114; TIGR00893 983545005065 putative substrate translocation pore; other site 983545005066 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545005067 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545005068 substrate binding site [chemical binding]; other site 983545005069 ATP binding site [chemical binding]; other site 983545005070 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 983545005071 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545005072 active site 983545005073 intersubunit interface [polypeptide binding]; other site 983545005074 catalytic residue [active] 983545005075 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 983545005076 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 983545005077 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 983545005078 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 983545005079 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 983545005080 NADP binding site [chemical binding]; other site 983545005081 dimer interface [polypeptide binding]; other site 983545005082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545005083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545005084 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 983545005085 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 983545005086 putative NAD(P) binding site [chemical binding]; other site 983545005087 dimer interface [polypeptide binding]; other site 983545005088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545005089 Coenzyme A binding pocket [chemical binding]; other site 983545005090 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 983545005091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545005092 dimer interface [polypeptide binding]; other site 983545005093 active site 983545005094 metal binding site [ion binding]; metal-binding site 983545005095 glutathione binding site [chemical binding]; other site 983545005096 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 983545005097 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 983545005098 EamA-like transporter family; Region: EamA; cl17759 983545005099 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 983545005100 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983545005101 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 983545005102 putative NAD(P) binding site [chemical binding]; other site 983545005103 homodimer interface [polypeptide binding]; other site 983545005104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545005105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545005106 putative DNA binding site [nucleotide binding]; other site 983545005107 putative Zn2+ binding site [ion binding]; other site 983545005108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545005109 dimerization interface [polypeptide binding]; other site 983545005110 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 983545005111 DNA-binding site [nucleotide binding]; DNA binding site 983545005112 RNA-binding motif; other site 983545005113 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 983545005114 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545005115 Beta-lactamase; Region: Beta-lactamase; pfam00144 983545005116 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545005117 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545005118 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 983545005119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545005120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545005121 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545005122 putative effector binding pocket; other site 983545005123 dimerization interface [polypeptide binding]; other site 983545005124 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 983545005125 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 983545005126 active site 983545005127 nucleophile elbow; other site 983545005128 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 983545005129 putative substrate binding pocket [chemical binding]; other site 983545005130 trimer interface [polypeptide binding]; other site 983545005131 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545005132 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 983545005133 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 983545005134 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 983545005135 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545005136 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545005137 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 983545005138 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545005139 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545005140 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545005141 catalytic loop [active] 983545005142 iron binding site [ion binding]; other site 983545005143 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545005144 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 983545005145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545005146 ATP binding site [chemical binding]; other site 983545005147 putative Mg++ binding site [ion binding]; other site 983545005148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545005149 nucleotide binding region [chemical binding]; other site 983545005150 ATP-binding site [chemical binding]; other site 983545005151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545005152 salt bridge; other site 983545005153 non-specific DNA binding site [nucleotide binding]; other site 983545005154 sequence-specific DNA binding site [nucleotide binding]; other site 983545005155 transcriptional regulator BetI; Validated; Region: PRK00767 983545005156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545005157 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 983545005158 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 983545005159 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545005160 NAD(P) binding site [chemical binding]; other site 983545005161 catalytic residues [active] 983545005162 choline dehydrogenase; Validated; Region: PRK02106 983545005163 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545005164 BCCT family transporter; Region: BCCT; cl00569 983545005165 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005166 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005167 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005168 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983545005169 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 983545005170 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 983545005171 active site 983545005172 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545005173 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 983545005174 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545005175 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545005176 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 983545005177 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545005178 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 983545005179 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545005180 DNA binding residues [nucleotide binding] 983545005181 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545005182 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 983545005183 putative active site [active] 983545005184 putative FMN binding site [chemical binding]; other site 983545005185 putative substrate binding site [chemical binding]; other site 983545005186 putative catalytic residue [active] 983545005187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545005188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545005189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545005190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545005191 dimerization interface [polypeptide binding]; other site 983545005192 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 983545005193 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005194 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005195 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545005196 Sulfatase; Region: Sulfatase; pfam00884 983545005197 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 983545005198 SmpB-tmRNA interface; other site 983545005199 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 983545005200 putative coenzyme Q binding site [chemical binding]; other site 983545005201 hypothetical protein; Validated; Region: PRK01777 983545005202 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 983545005203 PEP synthetase regulatory protein; Provisional; Region: PRK05339 983545005204 phosphoenolpyruvate synthase; Validated; Region: PRK06464 983545005205 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 983545005206 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 983545005207 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 983545005208 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545005209 FAD binding domain; Region: FAD_binding_4; pfam01565 983545005210 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 983545005211 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 983545005212 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 983545005213 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 983545005214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545005215 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 983545005216 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 983545005217 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 983545005218 putative active site [active] 983545005219 Zn binding site [ion binding]; other site 983545005220 Response regulator receiver domain; Region: Response_reg; pfam00072 983545005221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005222 active site 983545005223 phosphorylation site [posttranslational modification] 983545005224 intermolecular recognition site; other site 983545005225 dimerization interface [polypeptide binding]; other site 983545005226 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 983545005227 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 983545005228 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545005229 Predicted flavoprotein [General function prediction only]; Region: COG0431 983545005230 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 983545005231 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 983545005232 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 983545005233 short chain dehydrogenase; Provisional; Region: PRK06123 983545005234 classical (c) SDRs; Region: SDR_c; cd05233 983545005235 NAD(P) binding site [chemical binding]; other site 983545005236 active site 983545005237 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 983545005238 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 983545005239 GTP-binding protein YchF; Reviewed; Region: PRK09601 983545005240 YchF GTPase; Region: YchF; cd01900 983545005241 G1 box; other site 983545005242 GTP/Mg2+ binding site [chemical binding]; other site 983545005243 Switch I region; other site 983545005244 G2 box; other site 983545005245 Switch II region; other site 983545005246 G3 box; other site 983545005247 G4 box; other site 983545005248 G5 box; other site 983545005249 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 983545005250 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 983545005251 putative active site [active] 983545005252 catalytic residue [active] 983545005253 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 983545005254 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 983545005255 5S rRNA interface [nucleotide binding]; other site 983545005256 CTC domain interface [polypeptide binding]; other site 983545005257 L16 interface [polypeptide binding]; other site 983545005258 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545005259 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545005260 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 983545005261 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 983545005262 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545005263 active site 983545005264 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 983545005265 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 983545005266 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 983545005267 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 983545005268 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 983545005269 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 983545005270 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 983545005271 tRNA; other site 983545005272 putative tRNA binding site [nucleotide binding]; other site 983545005273 putative NADP binding site [chemical binding]; other site 983545005274 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 983545005275 peptide chain release factor 1; Validated; Region: prfA; PRK00591 983545005276 This domain is found in peptide chain release factors; Region: PCRF; smart00937 983545005277 RF-1 domain; Region: RF-1; pfam00472 983545005278 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 983545005279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545005280 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545005281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005282 active site 983545005283 phosphorylation site [posttranslational modification] 983545005284 intermolecular recognition site; other site 983545005285 dimerization interface [polypeptide binding]; other site 983545005286 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 983545005287 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545005288 Zn2+ binding site [ion binding]; other site 983545005289 Mg2+ binding site [ion binding]; other site 983545005290 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 983545005291 Uncharacterized conserved protein [Function unknown]; Region: COG2912 983545005292 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 983545005293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545005294 TPR motif; other site 983545005295 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 983545005296 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983545005297 inhibitor-cofactor binding pocket; inhibition site 983545005298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545005299 catalytic residue [active] 983545005300 biotin synthase; Provisional; Region: PRK15108 983545005301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545005302 FeS/SAM binding site; other site 983545005303 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 983545005304 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 983545005305 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 983545005306 substrate-cofactor binding pocket; other site 983545005307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545005308 catalytic residue [active] 983545005309 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 983545005310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545005311 S-adenosylmethionine binding site [chemical binding]; other site 983545005312 AAA domain; Region: AAA_26; pfam13500 983545005313 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 983545005314 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005315 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005316 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 983545005317 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 983545005318 putative NAD(P) binding site [chemical binding]; other site 983545005319 dimer interface [polypeptide binding]; other site 983545005320 Major royal jelly protein; Region: MRJP; pfam03022 983545005321 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545005322 putative catalytic residues [active] 983545005323 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 983545005324 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 983545005325 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 983545005326 Part of AAA domain; Region: AAA_19; pfam13245 983545005327 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 983545005328 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 983545005329 AAA domain; Region: AAA_30; pfam13604 983545005330 Family description; Region: UvrD_C_2; pfam13538 983545005331 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545005332 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983545005333 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 983545005334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545005335 catalytic residue [active] 983545005336 Fe-S metabolism associated domain; Region: SufE; cl00951 983545005337 Isochorismatase family; Region: Isochorismatase; pfam00857 983545005338 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 983545005339 catalytic triad [active] 983545005340 dimer interface [polypeptide binding]; other site 983545005341 conserved cis-peptide bond; other site 983545005342 Purine nucleoside permease (NUP); Region: NUP; cl17832 983545005343 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 983545005344 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 983545005345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545005346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005347 metal binding site [ion binding]; metal-binding site 983545005348 active site 983545005349 I-site; other site 983545005350 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545005351 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 983545005352 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545005353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005354 metal binding site [ion binding]; metal-binding site 983545005355 active site 983545005356 I-site; other site 983545005357 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 983545005358 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 983545005359 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 983545005360 putative sulfate transport protein CysZ; Validated; Region: PRK04949 983545005361 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545005362 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 983545005363 Walker A/P-loop; other site 983545005364 ATP binding site [chemical binding]; other site 983545005365 Q-loop/lid; other site 983545005366 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 983545005367 ABC transporter signature motif; other site 983545005368 Walker B; other site 983545005369 D-loop; other site 983545005370 H-loop/switch region; other site 983545005371 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 983545005372 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 983545005373 FtsZ protein binding site [polypeptide binding]; other site 983545005374 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 983545005375 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 983545005376 nucleotide binding pocket [chemical binding]; other site 983545005377 K-X-D-G motif; other site 983545005378 catalytic site [active] 983545005379 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 983545005380 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 983545005381 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 983545005382 Dimer interface [polypeptide binding]; other site 983545005383 BRCT sequence motif; other site 983545005384 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 983545005385 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 983545005386 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 983545005387 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 983545005388 Competence protein; Region: Competence; pfam03772 983545005389 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 983545005390 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 983545005391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983545005392 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 983545005393 Walker A/P-loop; other site 983545005394 ATP binding site [chemical binding]; other site 983545005395 Q-loop/lid; other site 983545005396 ABC transporter signature motif; other site 983545005397 Walker B; other site 983545005398 D-loop; other site 983545005399 H-loop/switch region; other site 983545005400 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 983545005401 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 983545005402 Uncharacterized conserved protein [Function unknown]; Region: COG2835 983545005403 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 983545005404 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 983545005405 Ligand binding site; other site 983545005406 oligomer interface; other site 983545005407 C factor cell-cell signaling protein; Provisional; Region: PRK09009 983545005408 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545005409 NADP binding site [chemical binding]; other site 983545005410 homodimer interface [polypeptide binding]; other site 983545005411 active site 983545005412 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545005413 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 983545005414 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545005415 catalytic residue [active] 983545005416 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545005417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005418 metal binding site [ion binding]; metal-binding site 983545005419 active site 983545005420 I-site; other site 983545005421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545005422 Coenzyme A binding pocket [chemical binding]; other site 983545005423 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 983545005424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545005425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545005426 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545005427 dimerization interface [polypeptide binding]; other site 983545005428 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 983545005429 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 983545005430 putative ATP binding site [chemical binding]; other site 983545005431 putative substrate interface [chemical binding]; other site 983545005432 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 983545005433 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 983545005434 Substrate binding site; other site 983545005435 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 983545005436 phosphomannomutase CpsG; Provisional; Region: PRK15414 983545005437 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 983545005438 active site 983545005439 substrate binding site [chemical binding]; other site 983545005440 metal binding site [ion binding]; metal-binding site 983545005441 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 983545005442 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 983545005443 dimer interface [polypeptide binding]; other site 983545005444 active site 983545005445 citrylCoA binding site [chemical binding]; other site 983545005446 NADH binding [chemical binding]; other site 983545005447 cationic pore residues; other site 983545005448 oxalacetate/citrate binding site [chemical binding]; other site 983545005449 coenzyme A binding site [chemical binding]; other site 983545005450 catalytic triad [active] 983545005451 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 983545005452 Iron-sulfur protein interface; other site 983545005453 proximal quinone binding site [chemical binding]; other site 983545005454 SdhD (CybS) interface [polypeptide binding]; other site 983545005455 proximal heme binding site [chemical binding]; other site 983545005456 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 983545005457 SdhC subunit interface [polypeptide binding]; other site 983545005458 proximal heme binding site [chemical binding]; other site 983545005459 cardiolipin binding site; other site 983545005460 Iron-sulfur protein interface; other site 983545005461 proximal quinone binding site [chemical binding]; other site 983545005462 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 983545005463 L-aspartate oxidase; Provisional; Region: PRK06175 983545005464 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 983545005465 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 983545005466 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 983545005467 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 983545005468 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 983545005469 TPP-binding site [chemical binding]; other site 983545005470 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 983545005471 dimer interface [polypeptide binding]; other site 983545005472 PYR/PP interface [polypeptide binding]; other site 983545005473 TPP binding site [chemical binding]; other site 983545005474 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545005475 E3 interaction surface; other site 983545005476 lipoyl attachment site [posttranslational modification]; other site 983545005477 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 983545005478 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545005479 E3 interaction surface; other site 983545005480 lipoyl attachment site [posttranslational modification]; other site 983545005481 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 983545005482 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 983545005483 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 983545005484 CoA-ligase; Region: Ligase_CoA; pfam00549 983545005485 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 983545005486 CoA binding domain; Region: CoA_binding; pfam02629 983545005487 CoA-ligase; Region: Ligase_CoA; pfam00549 983545005488 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545005489 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545005490 Predicted transcriptional regulators [Transcription]; Region: COG1733 983545005491 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 983545005492 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545005493 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545005494 substrate binding pocket [chemical binding]; other site 983545005495 membrane-bound complex binding site; other site 983545005496 hinge residues; other site 983545005497 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 983545005498 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 983545005499 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 983545005500 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 983545005501 active site pocket [active] 983545005502 oxyanion hole [active] 983545005503 catalytic triad [active] 983545005504 active site nucleophile [active] 983545005505 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005506 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983545005507 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 983545005508 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545005509 catalytic core [active] 983545005510 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545005511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545005512 active site 983545005513 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 983545005514 Phosphotransferase enzyme family; Region: APH; pfam01636 983545005515 putative active site [active] 983545005516 putative substrate binding site [chemical binding]; other site 983545005517 ATP binding site [chemical binding]; other site 983545005518 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545005519 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 983545005520 NAD(P) binding site [chemical binding]; other site 983545005521 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545005522 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983545005523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545005524 TPR motif; other site 983545005525 binding surface 983545005526 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 983545005527 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 983545005528 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545005529 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545005530 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545005531 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 983545005532 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545005533 tetramer interface [polypeptide binding]; other site 983545005534 active site 983545005535 Mg2+/Mn2+ binding site [ion binding]; other site 983545005536 Flagellin N-methylase; Region: FliB; cl00497 983545005537 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 983545005538 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 983545005539 active site 983545005540 dimer interface [polypeptide binding]; other site 983545005541 YHYH protein; Region: YHYH; pfam14240 983545005542 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005543 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983545005544 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005545 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545005546 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545005547 DNA binding site [nucleotide binding] 983545005548 domain linker motif; other site 983545005549 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 983545005550 putative dimerization interface [polypeptide binding]; other site 983545005551 putative ligand binding site [chemical binding]; other site 983545005552 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545005553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005554 Trehalase; Region: Trehalase; cl17346 983545005555 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 983545005556 putative active site [active] 983545005557 Zn binding site [ion binding]; other site 983545005558 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 983545005559 conserved cys residue [active] 983545005560 S-formylglutathione hydrolase; Region: PLN02442 983545005561 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 983545005562 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 983545005563 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 983545005564 substrate binding site [chemical binding]; other site 983545005565 catalytic Zn binding site [ion binding]; other site 983545005566 NAD binding site [chemical binding]; other site 983545005567 structural Zn binding site [ion binding]; other site 983545005568 dimer interface [polypeptide binding]; other site 983545005569 Amidohydrolase; Region: Amidohydro_2; pfam04909 983545005570 aldose dehydrogenase; Validated; Region: PRK06398 983545005571 classical (c) SDRs; Region: SDR_c; cd05233 983545005572 NAD(P) binding site [chemical binding]; other site 983545005573 active site 983545005574 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 983545005575 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 983545005576 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 983545005577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545005578 FeS/SAM binding site; other site 983545005579 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 983545005580 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 983545005581 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 983545005582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545005583 Walker A/P-loop; other site 983545005584 ATP binding site [chemical binding]; other site 983545005585 Q-loop/lid; other site 983545005586 ABC transporter signature motif; other site 983545005587 Walker B; other site 983545005588 D-loop; other site 983545005589 H-loop/switch region; other site 983545005590 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545005591 calcium binding site [ion binding]; other site 983545005592 active site 983545005593 catalytic residues [active] 983545005594 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545005595 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005596 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005597 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545005598 Sulfatase; Region: Sulfatase; cl17466 983545005599 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545005600 Sulfatase; Region: Sulfatase; pfam00884 983545005601 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 983545005602 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 983545005603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545005604 sequence-specific DNA binding site [nucleotide binding]; other site 983545005605 salt bridge; other site 983545005606 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 983545005607 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 983545005608 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 983545005609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545005610 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545005611 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 983545005612 Domain of unknown function (DUF303); Region: DUF303; pfam03629 983545005613 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545005614 Domain of unknown function (DUF303); Region: DUF303; pfam03629 983545005615 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 983545005616 YciI-like protein; Reviewed; Region: PRK12866 983545005617 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 983545005618 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 983545005619 dimer interface [polypeptide binding]; other site 983545005620 Trp docking motif [polypeptide binding]; other site 983545005621 active site 983545005622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545005623 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 983545005624 substrate binding pocket [chemical binding]; other site 983545005625 membrane-bound complex binding site; other site 983545005626 hinge residues; other site 983545005627 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 983545005628 Cytochrome c; Region: Cytochrom_C; pfam00034 983545005629 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 983545005630 ligand binding site [chemical binding]; other site 983545005631 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 983545005632 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 983545005633 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 983545005634 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 983545005635 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 983545005636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545005637 Walker A/P-loop; other site 983545005638 ATP binding site [chemical binding]; other site 983545005639 Q-loop/lid; other site 983545005640 ABC transporter signature motif; other site 983545005641 Walker B; other site 983545005642 D-loop; other site 983545005643 H-loop/switch region; other site 983545005644 ABC-2 type transporter; Region: ABC2_membrane; cl17235 983545005645 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 983545005646 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005647 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983545005648 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005649 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005650 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545005652 substrate binding pocket [chemical binding]; other site 983545005653 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983545005654 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 983545005655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545005656 dimer interface [polypeptide binding]; other site 983545005657 conserved gate region; other site 983545005658 putative PBP binding loops; other site 983545005659 ABC-ATPase subunit interface; other site 983545005660 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 983545005661 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545005662 Walker A/P-loop; other site 983545005663 ATP binding site [chemical binding]; other site 983545005664 Q-loop/lid; other site 983545005665 ABC transporter signature motif; other site 983545005666 Walker B; other site 983545005667 D-loop; other site 983545005668 H-loop/switch region; other site 983545005669 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 983545005670 Gram-negative porin; Region: Porin_4; pfam13609 983545005671 EthD domain; Region: EthD; cl17553 983545005672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545005673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005674 active site 983545005675 phosphorylation site [posttranslational modification] 983545005676 intermolecular recognition site; other site 983545005677 dimerization interface [polypeptide binding]; other site 983545005678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545005679 DNA binding residues [nucleotide binding] 983545005680 dimerization interface [polypeptide binding]; other site 983545005681 PAS fold; Region: PAS_7; pfam12860 983545005682 PAS fold; Region: PAS_7; pfam12860 983545005683 PAS domain; Region: PAS; smart00091 983545005684 PAS fold; Region: PAS_4; pfam08448 983545005685 putative active site [active] 983545005686 heme pocket [chemical binding]; other site 983545005687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545005688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545005689 dimer interface [polypeptide binding]; other site 983545005690 phosphorylation site [posttranslational modification] 983545005691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545005692 ATP binding site [chemical binding]; other site 983545005693 Mg2+ binding site [ion binding]; other site 983545005694 G-X-G motif; other site 983545005695 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545005696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005697 active site 983545005698 phosphorylation site [posttranslational modification] 983545005699 intermolecular recognition site; other site 983545005700 dimerization interface [polypeptide binding]; other site 983545005701 Uncharacterized conserved protein [Function unknown]; Region: COG3287 983545005702 FIST N domain; Region: FIST; pfam08495 983545005703 FIST C domain; Region: FIST_C; pfam10442 983545005704 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 983545005705 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 983545005706 4Fe-4S binding domain; Region: Fer4_5; pfam12801 983545005707 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545005708 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545005709 NAD(P) binding site [chemical binding]; other site 983545005710 catalytic residues [active] 983545005711 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 983545005712 NADH(P)-binding; Region: NAD_binding_10; pfam13460 983545005713 NAD(P) binding site [chemical binding]; other site 983545005714 putative active site [active] 983545005715 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 983545005716 30S subunit binding site; other site 983545005717 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 983545005718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545005719 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545005720 substrate binding pocket [chemical binding]; other site 983545005721 dimerization interface [polypeptide binding]; other site 983545005722 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 983545005723 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 983545005724 putative dimer interface [polypeptide binding]; other site 983545005725 putative anticodon binding site; other site 983545005726 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 983545005727 homodimer interface [polypeptide binding]; other site 983545005728 motif 1; other site 983545005729 motif 2; other site 983545005730 active site 983545005731 motif 3; other site 983545005732 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 983545005733 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 983545005734 dimer interface [polypeptide binding]; other site 983545005735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545005736 catalytic residue [active] 983545005737 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545005738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545005739 putative DNA binding site [nucleotide binding]; other site 983545005740 putative Zn2+ binding site [ion binding]; other site 983545005741 AsnC family; Region: AsnC_trans_reg; pfam01037 983545005742 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 983545005743 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 983545005744 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983545005745 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 983545005746 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545005747 active site 983545005748 dimer interface [polypeptide binding]; other site 983545005749 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 983545005750 dimer interface [polypeptide binding]; other site 983545005751 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545005752 active site 983545005753 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983545005754 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545005755 putative active site [active] 983545005756 putative metal binding site [ion binding]; other site 983545005757 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 983545005758 substrate binding site [chemical binding]; other site 983545005759 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 983545005760 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 983545005761 active site 983545005762 HIGH motif; other site 983545005763 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 983545005764 KMSKS motif; other site 983545005765 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 983545005766 tRNA binding surface [nucleotide binding]; other site 983545005767 anticodon binding site; other site 983545005768 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545005769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545005770 active site 983545005771 metal binding site [ion binding]; metal-binding site 983545005772 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983545005773 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 983545005774 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545005775 catalytic residue [active] 983545005776 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005777 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983545005778 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983545005780 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005781 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983545005782 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 983545005783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 983545005784 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 983545005785 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 983545005786 active site 983545005787 HIGH motif; other site 983545005788 KMSKS motif; other site 983545005789 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 983545005790 tRNA binding surface [nucleotide binding]; other site 983545005791 anticodon binding site; other site 983545005792 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 983545005793 dimer interface [polypeptide binding]; other site 983545005794 putative tRNA-binding site [nucleotide binding]; other site 983545005795 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 983545005796 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 983545005797 Walker A motif; other site 983545005798 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 983545005799 trimer interface [polypeptide binding]; other site 983545005800 active site 983545005801 Cupin; Region: Cupin_6; pfam12852 983545005802 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545005803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545005804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545005805 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 983545005806 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 983545005807 putative transposase OrfB; Reviewed; Region: PHA02517 983545005808 HTH-like domain; Region: HTH_21; pfam13276 983545005809 Integrase core domain; Region: rve; pfam00665 983545005810 Integrase core domain; Region: rve_3; pfam13683 983545005811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983545005812 Transposase; Region: HTH_Tnp_1; pfam01527 983545005813 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545005814 Beta-lactamase; Region: Beta-lactamase; pfam00144 983545005815 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545005816 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983545005817 catalytic residues [active] 983545005818 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545005819 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 983545005820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545005821 NAD binding site [chemical binding]; other site 983545005822 catalytic residues [active] 983545005823 substrate binding site [chemical binding]; other site 983545005824 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 983545005825 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 983545005826 NADP binding site [chemical binding]; other site 983545005827 homodimer interface [polypeptide binding]; other site 983545005828 active site 983545005829 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 983545005830 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 983545005831 NAD(P) binding site [chemical binding]; other site 983545005832 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 983545005833 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 983545005834 active site pocket [active] 983545005835 Transcriptional regulators [Transcription]; Region: GntR; COG1802 983545005836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545005837 DNA-binding site [nucleotide binding]; DNA binding site 983545005838 FCD domain; Region: FCD; pfam07729 983545005839 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545005840 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005841 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545005842 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545005843 SapC; Region: SapC; pfam07277 983545005844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545005845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545005846 dimer interface [polypeptide binding]; other site 983545005847 phosphorylation site [posttranslational modification] 983545005848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545005849 ATP binding site [chemical binding]; other site 983545005850 Mg2+ binding site [ion binding]; other site 983545005851 G-X-G motif; other site 983545005852 Response regulator receiver domain; Region: Response_reg; pfam00072 983545005853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005854 active site 983545005855 phosphorylation site [posttranslational modification] 983545005856 intermolecular recognition site; other site 983545005857 dimerization interface [polypeptide binding]; other site 983545005858 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 983545005859 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 983545005860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545005861 substrate binding pocket [chemical binding]; other site 983545005862 membrane-bound complex binding site; other site 983545005863 hinge residues; other site 983545005864 multidrug efflux protein; Reviewed; Region: PRK01766 983545005865 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 983545005866 cation binding site [ion binding]; other site 983545005867 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 983545005868 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 983545005869 dimer interface [polypeptide binding]; other site 983545005870 putative functional site; other site 983545005871 putative MPT binding site; other site 983545005872 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 983545005873 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 983545005874 ATP binding site [chemical binding]; other site 983545005875 substrate interface [chemical binding]; other site 983545005876 TraB family; Region: TraB; pfam01963 983545005877 nitrite reductase subunit NirD; Provisional; Region: PRK14989 983545005878 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 983545005879 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545005880 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 983545005881 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 983545005882 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 983545005883 [4Fe-4S] binding site [ion binding]; other site 983545005884 molybdopterin cofactor binding site; other site 983545005885 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 983545005886 molybdopterin cofactor binding site; other site 983545005887 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 983545005888 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 983545005889 active site 983545005890 SAM binding site [chemical binding]; other site 983545005891 homodimer interface [polypeptide binding]; other site 983545005892 hypothetical protein; Validated; Region: PRK09071 983545005893 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 983545005894 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 983545005895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545005896 active site 983545005897 phosphorylation site [posttranslational modification] 983545005898 intermolecular recognition site; other site 983545005899 dimerization interface [polypeptide binding]; other site 983545005900 ANTAR domain; Region: ANTAR; pfam03861 983545005901 NMT1-like family; Region: NMT1_2; pfam13379 983545005902 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983545005903 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 983545005904 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 983545005905 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 983545005906 catalytic residues [active] 983545005907 dimer interface [polypeptide binding]; other site 983545005908 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545005909 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545005910 elongation factor P; Provisional; Region: PRK04542 983545005911 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 983545005912 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 983545005913 RNA binding site [nucleotide binding]; other site 983545005914 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 983545005915 RNA binding site [nucleotide binding]; other site 983545005916 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 983545005917 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545005918 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005919 metal binding site [ion binding]; metal-binding site 983545005920 active site 983545005921 I-site; other site 983545005922 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 983545005923 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 983545005924 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 983545005925 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 983545005926 NADP binding site [chemical binding]; other site 983545005927 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 983545005928 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 983545005929 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 983545005930 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 983545005931 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545005932 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545005933 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 983545005934 Protein of unknown function (DUF989); Region: DUF989; pfam06181 983545005935 Predicted membrane protein [Function unknown]; Region: COG3748 983545005936 Cytochrome c; Region: Cytochrom_C; pfam00034 983545005937 guanine deaminase; Provisional; Region: PRK09228 983545005938 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 983545005939 active site 983545005940 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 983545005941 active site 983545005942 homotetramer interface [polypeptide binding]; other site 983545005943 putative OHCU decarboxylase; Provisional; Region: PRK13798 983545005944 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 983545005945 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 983545005946 XdhC Rossmann domain; Region: XdhC_C; pfam13478 983545005947 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 983545005948 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 983545005949 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545005950 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 983545005951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545005952 catalytic loop [active] 983545005953 iron binding site [ion binding]; other site 983545005954 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545005955 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 983545005956 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 983545005957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545005958 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 983545005959 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545005960 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 983545005961 active site 983545005962 catalytic site [active] 983545005963 tetramer interface [polypeptide binding]; other site 983545005964 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 983545005965 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983545005966 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 983545005967 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 983545005968 active site 983545005969 purine riboside binding site [chemical binding]; other site 983545005970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005971 putative substrate translocation pore; other site 983545005972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005973 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 983545005974 active site 983545005975 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 983545005976 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545005977 active site 983545005978 ATP binding site [chemical binding]; other site 983545005979 substrate binding site [chemical binding]; other site 983545005980 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545005981 substrate binding site [chemical binding]; other site 983545005982 activation loop (A-loop); other site 983545005983 activation loop (A-loop); other site 983545005984 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983545005985 NMT1-like family; Region: NMT1_2; pfam13379 983545005986 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 983545005987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545005988 dimer interface [polypeptide binding]; other site 983545005989 conserved gate region; other site 983545005990 putative PBP binding loops; other site 983545005991 ABC-ATPase subunit interface; other site 983545005992 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 983545005993 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 983545005994 Walker A/P-loop; other site 983545005995 ATP binding site [chemical binding]; other site 983545005996 Q-loop/lid; other site 983545005997 ABC transporter signature motif; other site 983545005998 Walker B; other site 983545005999 D-loop; other site 983545006000 H-loop/switch region; other site 983545006001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 983545006002 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 983545006003 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545006004 Predicted membrane protein [Function unknown]; Region: COG2119 983545006005 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 983545006006 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 983545006007 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 983545006008 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545006009 FtsX-like permease family; Region: FtsX; pfam02687 983545006010 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545006011 FtsX-like permease family; Region: FtsX; pfam02687 983545006012 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545006013 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983545006014 Walker A/P-loop; other site 983545006015 ATP binding site [chemical binding]; other site 983545006016 Q-loop/lid; other site 983545006017 ABC transporter signature motif; other site 983545006018 Walker B; other site 983545006019 D-loop; other site 983545006020 H-loop/switch region; other site 983545006021 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545006022 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545006023 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545006024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006025 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545006026 active site 983545006027 phosphorylation site [posttranslational modification] 983545006028 intermolecular recognition site; other site 983545006029 dimerization interface [polypeptide binding]; other site 983545006030 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 983545006031 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545006032 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006033 N-terminal plug; other site 983545006034 ligand-binding site [chemical binding]; other site 983545006035 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 983545006036 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545006037 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 983545006038 active site 983545006039 FMN binding site [chemical binding]; other site 983545006040 2,4-decadienoyl-CoA binding site; other site 983545006041 catalytic residue [active] 983545006042 4Fe-4S cluster binding site [ion binding]; other site 983545006043 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 983545006044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545006045 hypothetical protein; Provisional; Region: PRK11019 983545006046 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 983545006047 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 983545006048 Outer membrane efflux protein; Region: OEP; pfam02321 983545006049 Outer membrane efflux protein; Region: OEP; pfam02321 983545006050 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 983545006051 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545006052 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 983545006053 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983545006054 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 983545006055 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 983545006056 putative NAD(P) binding site [chemical binding]; other site 983545006057 putative substrate binding site [chemical binding]; other site 983545006058 catalytic Zn binding site [ion binding]; other site 983545006059 structural Zn binding site [ion binding]; other site 983545006060 dimer interface [polypeptide binding]; other site 983545006061 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 983545006062 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 983545006063 active site 983545006064 purine riboside binding site [chemical binding]; other site 983545006065 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 983545006066 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 983545006067 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983545006068 protein binding site [polypeptide binding]; other site 983545006069 Flagellar protein YcgR; Region: YcgR_2; pfam12945 983545006070 PilZ domain; Region: PilZ; pfam07238 983545006071 Protein of unknown function (DUF962); Region: DUF962; cl01879 983545006072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983545006073 Histidine kinase; Region: His_kinase; pfam06580 983545006074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006075 ATP binding site [chemical binding]; other site 983545006076 Mg2+ binding site [ion binding]; other site 983545006077 G-X-G motif; other site 983545006078 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983545006079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006080 active site 983545006081 phosphorylation site [posttranslational modification] 983545006082 intermolecular recognition site; other site 983545006083 dimerization interface [polypeptide binding]; other site 983545006084 LytTr DNA-binding domain; Region: LytTR; smart00850 983545006085 Cupin superfamily protein; Region: Cupin_4; pfam08007 983545006086 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 983545006087 cyclase homology domain; Region: CHD; cd07302 983545006088 nucleotidyl binding site; other site 983545006089 metal binding site [ion binding]; metal-binding site 983545006090 dimer interface [polypeptide binding]; other site 983545006091 adenylosuccinate lyase; Provisional; Region: PRK09285 983545006092 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 983545006093 tetramer interface [polypeptide binding]; other site 983545006094 active site 983545006095 Protein of unknown function (DUF489); Region: DUF489; pfam04356 983545006096 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 983545006097 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 983545006098 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 983545006099 pseudouridine synthase; Region: TIGR00093 983545006100 active site 983545006101 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 983545006102 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 983545006103 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 983545006104 DNA-binding site [nucleotide binding]; DNA binding site 983545006105 RNA-binding motif; other site 983545006106 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 983545006107 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 983545006108 Clp amino terminal domain; Region: Clp_N; pfam02861 983545006109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545006110 Walker A motif; other site 983545006111 ATP binding site [chemical binding]; other site 983545006112 Walker B motif; other site 983545006113 arginine finger; other site 983545006114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545006115 Walker A motif; other site 983545006116 ATP binding site [chemical binding]; other site 983545006117 Walker B motif; other site 983545006118 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 983545006119 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 983545006120 rRNA binding site [nucleotide binding]; other site 983545006121 predicted 30S ribosome binding site; other site 983545006122 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 983545006123 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 983545006124 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 983545006125 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 983545006126 thioredoxin reductase; Provisional; Region: PRK10262 983545006127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545006128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545006129 Protein of unknown function, DUF412; Region: DUF412; pfam04217 983545006130 hypothetical protein; Provisional; Region: PRK04860 983545006131 SprT homologues; Region: SprT; cl01182 983545006132 protease 4; Provisional; Region: PRK10949 983545006133 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 983545006134 tandem repeat interface [polypeptide binding]; other site 983545006135 oligomer interface [polypeptide binding]; other site 983545006136 active site residues [active] 983545006137 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 983545006138 tandem repeat interface [polypeptide binding]; other site 983545006139 oligomer interface [polypeptide binding]; other site 983545006140 active site residues [active] 983545006141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545006142 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 983545006143 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 983545006144 RNA/DNA hybrid binding site [nucleotide binding]; other site 983545006145 active site 983545006146 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 983545006147 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 983545006148 active site 983545006149 catalytic site [active] 983545006150 substrate binding site [chemical binding]; other site 983545006151 TIGR03503 family protein; Region: TIGR03503 983545006152 Domain of unknown function DUF21; Region: DUF21; pfam01595 983545006153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545006154 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 983545006155 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983545006156 Walker A/P-loop; other site 983545006157 ATP binding site [chemical binding]; other site 983545006158 Q-loop/lid; other site 983545006159 ABC transporter signature motif; other site 983545006160 Walker B; other site 983545006161 D-loop; other site 983545006162 H-loop/switch region; other site 983545006163 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 983545006164 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545006165 FtsX-like permease family; Region: FtsX; pfam02687 983545006166 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 983545006167 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 983545006168 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 983545006169 succinylarginine dihydrolase; Provisional; Region: PRK13281 983545006170 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 983545006171 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 983545006172 active site 983545006173 interdomain interaction site; other site 983545006174 putative metal-binding site [ion binding]; other site 983545006175 nucleotide binding site [chemical binding]; other site 983545006176 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 983545006177 domain I; other site 983545006178 DNA binding groove [nucleotide binding] 983545006179 phosphate binding site [ion binding]; other site 983545006180 domain II; other site 983545006181 domain III; other site 983545006182 nucleotide binding site [chemical binding]; other site 983545006183 catalytic site [active] 983545006184 domain IV; other site 983545006185 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 983545006186 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 983545006187 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 983545006188 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 983545006189 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 983545006190 HPP family; Region: HPP; pfam04982 983545006191 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 983545006192 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 983545006193 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 983545006194 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545006195 active site 983545006196 catalytic site [active] 983545006197 substrate binding site [chemical binding]; other site 983545006198 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 983545006199 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545006200 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 983545006201 Helix-turn-helix domain; Region: HTH_18; pfam12833 983545006202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545006203 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 983545006204 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 983545006205 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 983545006206 NAD(P) binding site [chemical binding]; other site 983545006207 catalytic residues [active] 983545006208 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 983545006209 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 983545006210 Zn binding site [ion binding]; other site 983545006211 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 983545006212 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 983545006213 dimer interface [polypeptide binding]; other site 983545006214 acyl-activating enzyme (AAE) consensus motif; other site 983545006215 putative active site [active] 983545006216 AMP binding site [chemical binding]; other site 983545006217 putative CoA binding site [chemical binding]; other site 983545006218 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 983545006219 classical (c) SDRs; Region: SDR_c; cd05233 983545006220 NAD(P) binding site [chemical binding]; other site 983545006221 active site 983545006222 haloalkane dehalogenase; Provisional; Region: PRK00870 983545006223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545006224 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545006225 substrate binding site [chemical binding]; other site 983545006226 oxyanion hole (OAH) forming residues; other site 983545006227 trimer interface [polypeptide binding]; other site 983545006228 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983545006229 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545006230 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545006231 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 983545006232 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545006233 dimer interface [polypeptide binding]; other site 983545006234 active site 983545006235 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545006236 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 983545006237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545006238 active site 983545006239 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545006240 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545006241 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545006242 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545006243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006244 metal binding site [ion binding]; metal-binding site 983545006245 active site 983545006246 I-site; other site 983545006247 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545006248 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 983545006249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545006250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545006251 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 983545006252 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 983545006253 inhibitor site; inhibition site 983545006254 active site 983545006255 dimer interface [polypeptide binding]; other site 983545006256 catalytic residue [active] 983545006257 Purine nucleoside permease (NUP); Region: NUP; pfam06516 983545006258 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 983545006259 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545006260 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545006261 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 983545006262 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 983545006263 active site 983545006264 putative substrate binding pocket [chemical binding]; other site 983545006265 xanthine permease; Region: pbuX; TIGR03173 983545006266 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545006267 active site 983545006268 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 983545006269 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 983545006270 active site residue [active] 983545006271 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 983545006272 active site residue [active] 983545006273 Uncharacterized conserved protein [Function unknown]; Region: COG2968 983545006274 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 983545006275 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 983545006276 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 983545006277 Proline dehydrogenase; Region: Pro_dh; pfam01619 983545006278 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 983545006279 Glutamate binding site [chemical binding]; other site 983545006280 NAD binding site [chemical binding]; other site 983545006281 catalytic residues [active] 983545006282 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545006283 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 983545006284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545006285 putative DNA binding site [nucleotide binding]; other site 983545006286 putative Zn2+ binding site [ion binding]; other site 983545006287 AsnC family; Region: AsnC_trans_reg; pfam01037 983545006288 dihydrodipicolinate reductase; Provisional; Region: PRK00048 983545006289 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 983545006290 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 983545006291 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 983545006292 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 983545006293 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 983545006294 catalytic site [active] 983545006295 subunit interface [polypeptide binding]; other site 983545006296 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 983545006297 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545006298 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 983545006299 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 983545006300 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545006301 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983545006302 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 983545006303 IMP binding site; other site 983545006304 dimer interface [polypeptide binding]; other site 983545006305 interdomain contacts; other site 983545006306 partial ornithine binding site; other site 983545006307 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 983545006308 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 983545006309 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 983545006310 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 983545006311 intracellular protease, PfpI family; Region: PfpI; TIGR01382 983545006312 proposed catalytic triad [active] 983545006313 conserved cys residue [active] 983545006314 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 983545006315 EamA-like transporter family; Region: EamA; pfam00892 983545006316 EamA-like transporter family; Region: EamA; pfam00892 983545006317 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 983545006318 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 983545006319 putative active site [active] 983545006320 catalytic triad [active] 983545006321 putative dimer interface [polypeptide binding]; other site 983545006322 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 983545006323 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545006324 Transporter associated domain; Region: CorC_HlyC; smart01091 983545006325 metal-binding heat shock protein; Provisional; Region: PRK00016 983545006326 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 983545006327 PhoH-like protein; Region: PhoH; pfam02562 983545006328 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 983545006329 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 983545006330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545006331 FeS/SAM binding site; other site 983545006332 TRAM domain; Region: TRAM; pfam01938 983545006333 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 983545006334 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 983545006335 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 983545006336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545006337 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 983545006338 dimerization interface [polypeptide binding]; other site 983545006339 substrate binding pocket [chemical binding]; other site 983545006340 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545006341 Protein of unknown function (DUF423); Region: DUF423; pfam04241 983545006342 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 983545006343 FtsJ-like methyltransferase; Region: FtsJ; cl17430 983545006344 SeqA protein; Region: SeqA; pfam03925 983545006345 phosphoglucomutase; Validated; Region: PRK07564 983545006346 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 983545006347 active site 983545006348 substrate binding site [chemical binding]; other site 983545006349 metal binding site [ion binding]; metal-binding site 983545006350 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 983545006351 homodimer interface [polypeptide binding]; other site 983545006352 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 983545006353 active site pocket [active] 983545006354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006355 metal binding site [ion binding]; metal-binding site 983545006356 active site 983545006357 I-site; other site 983545006358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545006359 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 983545006360 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983545006361 putative active site [active] 983545006362 Zn binding site [ion binding]; other site 983545006363 hypothetical protein; Provisional; Region: PRK02877 983545006364 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 983545006365 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 983545006366 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 983545006367 metal binding site [ion binding]; metal-binding site 983545006368 dimer interface [polypeptide binding]; other site 983545006369 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 983545006370 ArsC family; Region: ArsC; pfam03960 983545006371 putative catalytic residues [active] 983545006372 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 983545006373 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545006374 active site 983545006375 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545006376 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006377 metal binding site [ion binding]; metal-binding site 983545006378 active site 983545006379 I-site; other site 983545006380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545006381 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 983545006382 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545006383 active site 983545006384 catalytic site [active] 983545006385 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545006386 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545006387 DNA binding site [nucleotide binding] 983545006388 domain linker motif; other site 983545006389 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 983545006390 putative dimerization interface [polypeptide binding]; other site 983545006391 putative ligand binding site [chemical binding]; other site 983545006392 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 983545006393 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545006394 active site 983545006395 HIGH motif; other site 983545006396 nucleotide binding site [chemical binding]; other site 983545006397 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 983545006398 KMSKS motif; other site 983545006399 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 983545006400 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 983545006401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006402 NAD(P) binding site [chemical binding]; other site 983545006403 active site 983545006404 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 983545006405 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 983545006406 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 983545006407 putative inner membrane peptidase; Provisional; Region: PRK11778 983545006408 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 983545006409 tandem repeat interface [polypeptide binding]; other site 983545006410 oligomer interface [polypeptide binding]; other site 983545006411 active site residues [active] 983545006412 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545006413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545006414 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 983545006415 active site 983545006416 Zn binding site [ion binding]; other site 983545006417 DNA photolyase; Region: DNA_photolyase; pfam00875 983545006418 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 983545006419 Uncharacterized conserved protein [Function unknown]; Region: COG0327 983545006420 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 983545006421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545006422 S-adenosylmethionine binding site [chemical binding]; other site 983545006423 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 983545006424 catalytic residues [active] 983545006425 dimer interface [polypeptide binding]; other site 983545006426 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 983545006427 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 983545006428 Protein of unknown function (DUF342); Region: DUF342; pfam03961 983545006429 exonuclease I; Provisional; Region: sbcB; PRK11779 983545006430 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 983545006431 active site 983545006432 catalytic site [active] 983545006433 substrate binding site [chemical binding]; other site 983545006434 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 983545006435 FOG: CBS domain [General function prediction only]; Region: COG0517 983545006436 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 983545006437 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 983545006438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545006439 ATP binding site [chemical binding]; other site 983545006440 putative Mg++ binding site [ion binding]; other site 983545006441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545006442 nucleotide binding region [chemical binding]; other site 983545006443 ATP-binding site [chemical binding]; other site 983545006444 Helicase associated domain (HA2); Region: HA2; pfam04408 983545006445 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 983545006446 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 983545006447 PilZ domain; Region: PilZ; pfam07238 983545006448 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 983545006449 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 983545006450 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 983545006451 putative RNA binding site [nucleotide binding]; other site 983545006452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545006453 S-adenosylmethionine binding site [chemical binding]; other site 983545006454 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 983545006455 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 983545006456 NAD(P) binding site [chemical binding]; other site 983545006457 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 983545006458 EF-hand domain pair; Region: EF_hand_5; pfam13499 983545006459 pseudo EF-hand loop; other site 983545006460 peptide binding pocket; other site 983545006461 Ca2+ binding site [ion binding]; other site 983545006462 Secreted protein acidic and rich in cysteine Ca binding region; Region: SPARC_Ca_bdg; pfam10591 983545006463 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 983545006464 active site 983545006465 homodimer interface [polypeptide binding]; other site 983545006466 catalytic site [active] 983545006467 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 983545006468 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 983545006469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545006470 active site 983545006471 motif I; other site 983545006472 motif II; other site 983545006473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 983545006474 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 983545006475 active site 983545006476 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 983545006477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545006478 FeS/SAM binding site; other site 983545006479 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 983545006480 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 983545006481 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 983545006482 GTP binding site; other site 983545006483 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 983545006484 MPT binding site; other site 983545006485 trimer interface [polypeptide binding]; other site 983545006486 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 983545006487 trimer interface [polypeptide binding]; other site 983545006488 dimer interface [polypeptide binding]; other site 983545006489 putative active site [active] 983545006490 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 983545006491 MoaE interaction surface [polypeptide binding]; other site 983545006492 MoeB interaction surface [polypeptide binding]; other site 983545006493 thiocarboxylated glycine; other site 983545006494 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 983545006495 MoaE homodimer interface [polypeptide binding]; other site 983545006496 MoaD interaction [polypeptide binding]; other site 983545006497 active site residues [active] 983545006498 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 983545006499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 983545006500 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 983545006501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545006502 dimer interface [polypeptide binding]; other site 983545006503 conserved gate region; other site 983545006504 putative PBP binding loops; other site 983545006505 ABC-ATPase subunit interface; other site 983545006506 ferric uptake regulator; Provisional; Region: fur; PRK09462 983545006507 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 983545006508 metal binding site 2 [ion binding]; metal-binding site 983545006509 putative DNA binding helix; other site 983545006510 metal binding site 1 [ion binding]; metal-binding site 983545006511 dimer interface [polypeptide binding]; other site 983545006512 structural Zn2+ binding site [ion binding]; other site 983545006513 flavodoxin FldA; Validated; Region: PRK09267 983545006514 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 983545006515 acyl-CoA esterase; Provisional; Region: PRK10673 983545006516 PGAP1-like protein; Region: PGAP1; pfam07819 983545006517 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 983545006518 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 983545006519 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 983545006520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545006521 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 983545006522 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545006523 Ligand binding site [chemical binding]; other site 983545006524 Electron transfer flavoprotein domain; Region: ETF; pfam01012 983545006525 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545006526 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545006527 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983545006528 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 983545006529 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 983545006530 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 983545006531 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 983545006532 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545006533 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545006534 conserved cys residue [active] 983545006535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545006536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545006537 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 983545006538 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545006539 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545006540 active site 983545006541 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545006542 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545006543 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545006544 NAD(P) binding site [chemical binding]; other site 983545006545 substrate binding site [chemical binding]; other site 983545006546 dimer interface [polypeptide binding]; other site 983545006547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545006548 classical (c) SDRs; Region: SDR_c; cd05233 983545006549 NAD(P) binding site [chemical binding]; other site 983545006550 active site 983545006551 short chain dehydrogenase; Provisional; Region: PRK07035 983545006552 classical (c) SDRs; Region: SDR_c; cd05233 983545006553 NAD(P) binding site [chemical binding]; other site 983545006554 active site 983545006555 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 983545006556 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 983545006557 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 983545006558 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 983545006559 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545006560 ATP binding site [chemical binding]; other site 983545006561 Mg++ binding site [ion binding]; other site 983545006562 motif III; other site 983545006563 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545006564 nucleotide binding region [chemical binding]; other site 983545006565 ATP-binding site [chemical binding]; other site 983545006566 ribonuclease E; Reviewed; Region: rne; PRK10811 983545006567 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 983545006568 homodimer interface [polypeptide binding]; other site 983545006569 oligonucleotide binding site [chemical binding]; other site 983545006570 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 983545006571 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545006572 RNA binding surface [nucleotide binding]; other site 983545006573 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983545006574 active site 983545006575 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 983545006576 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 983545006577 NAD binding site [chemical binding]; other site 983545006578 substrate binding site [chemical binding]; other site 983545006579 homodimer interface [polypeptide binding]; other site 983545006580 active site 983545006581 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 983545006582 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 983545006583 substrate binding site; other site 983545006584 tetramer interface; other site 983545006585 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 983545006586 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 983545006587 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 983545006588 NADP binding site [chemical binding]; other site 983545006589 active site 983545006590 putative substrate binding site [chemical binding]; other site 983545006591 Maf-like protein; Region: Maf; pfam02545 983545006592 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 983545006593 active site 983545006594 dimer interface [polypeptide binding]; other site 983545006595 hypothetical protein; Provisional; Region: PRK11193 983545006596 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 983545006597 putative phosphate acyltransferase; Provisional; Region: PRK05331 983545006598 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 983545006599 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983545006600 dimer interface [polypeptide binding]; other site 983545006601 active site 983545006602 CoA binding pocket [chemical binding]; other site 983545006603 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 983545006604 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 983545006605 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545006606 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 983545006607 NAD(P) binding site [chemical binding]; other site 983545006608 homotetramer interface [polypeptide binding]; other site 983545006609 homodimer interface [polypeptide binding]; other site 983545006610 active site 983545006611 acyl carrier protein; Provisional; Region: acpP; PRK00982 983545006612 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 983545006613 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983545006614 dimer interface [polypeptide binding]; other site 983545006615 active site 983545006616 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 983545006617 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 983545006618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006619 catalytic residue [active] 983545006620 YceG-like family; Region: YceG; pfam02618 983545006621 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 983545006622 dimerization interface [polypeptide binding]; other site 983545006623 thymidylate kinase; Validated; Region: tmk; PRK00698 983545006624 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 983545006625 TMP-binding site; other site 983545006626 ATP-binding site [chemical binding]; other site 983545006627 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 983545006628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 983545006629 Walker A motif; other site 983545006630 ATP binding site [chemical binding]; other site 983545006631 DNA polymerase III subunit delta'; Validated; Region: PRK08485 983545006632 Walker B motif; other site 983545006633 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 983545006634 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 983545006635 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545006636 active site 983545006637 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 983545006638 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 983545006639 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 983545006640 catalytic site [active] 983545006641 active site 983545006642 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 983545006643 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 983545006644 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 983545006645 Trp docking motif [polypeptide binding]; other site 983545006646 putative active site [active] 983545006647 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 983545006648 Int/Topo IB signature motif; other site 983545006649 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 983545006650 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 983545006651 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 983545006652 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983545006653 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983545006654 catalytic residues [active] 983545006655 Winged helix-turn helix; Region: HTH_29; pfam13551 983545006656 Helix-turn-helix domain; Region: HTH_28; pfam13518 983545006657 Integrase core domain; Region: rve; pfam00665 983545006658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 983545006659 Integrase core domain; Region: rve_3; pfam13683 983545006660 Amino acid permease; Region: AA_permease_2; pfam13520 983545006661 Predicted transporter component [General function prediction only]; Region: COG2391 983545006662 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 983545006663 Predicted transporter component [General function prediction only]; Region: COG2391 983545006664 Sulphur transport; Region: Sulf_transp; pfam04143 983545006665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545006666 dimerization interface [polypeptide binding]; other site 983545006667 putative DNA binding site [nucleotide binding]; other site 983545006668 putative Zn2+ binding site [ion binding]; other site 983545006669 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 983545006670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006671 putative active site [active] 983545006672 heme pocket [chemical binding]; other site 983545006673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006674 dimer interface [polypeptide binding]; other site 983545006675 phosphorylation site [posttranslational modification] 983545006676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006677 ATP binding site [chemical binding]; other site 983545006678 Mg2+ binding site [ion binding]; other site 983545006679 G-X-G motif; other site 983545006680 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006682 active site 983545006683 phosphorylation site [posttranslational modification] 983545006684 intermolecular recognition site; other site 983545006685 dimerization interface [polypeptide binding]; other site 983545006686 universal stress protein UspE; Provisional; Region: PRK11175 983545006687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006688 Ligand Binding Site [chemical binding]; other site 983545006689 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006690 Ligand Binding Site [chemical binding]; other site 983545006691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006692 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 983545006693 putative active site [active] 983545006694 heme pocket [chemical binding]; other site 983545006695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006696 dimer interface [polypeptide binding]; other site 983545006697 phosphorylation site [posttranslational modification] 983545006698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006699 ATP binding site [chemical binding]; other site 983545006700 Mg2+ binding site [ion binding]; other site 983545006701 G-X-G motif; other site 983545006702 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 983545006703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006704 active site 983545006705 phosphorylation site [posttranslational modification] 983545006706 intermolecular recognition site; other site 983545006707 dimerization interface [polypeptide binding]; other site 983545006708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545006709 DNA binding residues [nucleotide binding] 983545006710 dimerization interface [polypeptide binding]; other site 983545006711 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545006712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006713 active site 983545006714 phosphorylation site [posttranslational modification] 983545006715 intermolecular recognition site; other site 983545006716 dimerization interface [polypeptide binding]; other site 983545006717 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 983545006718 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983545006719 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545006720 metal-binding site [ion binding] 983545006721 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983545006722 Soluble P-type ATPase [General function prediction only]; Region: COG4087 983545006723 Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787 983545006724 DNA binding residues [nucleotide binding] 983545006725 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 983545006726 dimer interface [polypeptide binding]; other site 983545006727 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006729 active site 983545006730 phosphorylation site [posttranslational modification] 983545006731 intermolecular recognition site; other site 983545006732 dimerization interface [polypeptide binding]; other site 983545006733 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545006734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006735 metal binding site [ion binding]; metal-binding site 983545006736 active site 983545006737 I-site; other site 983545006738 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 983545006739 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 983545006740 putative ligand binding site [chemical binding]; other site 983545006741 putative NAD binding site [chemical binding]; other site 983545006742 catalytic site [active] 983545006743 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 983545006744 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 983545006745 active site 983545006746 ADP/pyrophosphate binding site [chemical binding]; other site 983545006747 dimerization interface [polypeptide binding]; other site 983545006748 allosteric effector site; other site 983545006749 fructose-1,6-bisphosphate binding site; other site 983545006750 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545006751 active site residue [active] 983545006752 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 983545006753 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545006754 ligand binding site [chemical binding]; other site 983545006755 flexible hinge region; other site 983545006756 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 983545006757 putative switch regulator; other site 983545006758 non-specific DNA interactions [nucleotide binding]; other site 983545006759 DNA binding site [nucleotide binding] 983545006760 sequence specific DNA binding site [nucleotide binding]; other site 983545006761 putative cAMP binding site [chemical binding]; other site 983545006762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545006763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545006764 dimer interface [polypeptide binding]; other site 983545006765 phosphorylation site [posttranslational modification] 983545006766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006767 ATP binding site [chemical binding]; other site 983545006768 Mg2+ binding site [ion binding]; other site 983545006769 G-X-G motif; other site 983545006770 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006772 active site 983545006773 phosphorylation site [posttranslational modification] 983545006774 intermolecular recognition site; other site 983545006775 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545006776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545006777 active site 983545006778 phosphorylation site [posttranslational modification] 983545006779 intermolecular recognition site; other site 983545006780 dimerization interface [polypeptide binding]; other site 983545006781 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 983545006782 dimerization interface [polypeptide binding]; other site 983545006783 substrate binding site [chemical binding]; other site 983545006784 active site 983545006785 calcium binding site [ion binding]; other site 983545006786 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 983545006787 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983545006788 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545006789 ligand binding site [chemical binding]; other site 983545006790 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545006791 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545006792 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545006793 DNA binding residues [nucleotide binding] 983545006794 Conserved TM helix; Region: TM_helix; pfam05552 983545006795 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545006796 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545006797 Domain of unknown function DUF21; Region: DUF21; pfam01595 983545006798 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 983545006799 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 983545006800 heme binding site [chemical binding]; other site 983545006801 ferroxidase pore; other site 983545006802 ferroxidase diiron center [ion binding]; other site 983545006803 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 983545006804 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 983545006805 heme binding site [chemical binding]; other site 983545006806 ferroxidase pore; other site 983545006807 ferroxidase diiron center [ion binding]; other site 983545006808 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 983545006809 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 983545006810 Low-spin heme binding site [chemical binding]; other site 983545006811 Putative water exit pathway; other site 983545006812 Binuclear center (active site) [active] 983545006813 Putative proton exit pathway; other site 983545006814 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 983545006815 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 983545006816 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 983545006817 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 983545006818 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 983545006819 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 983545006820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 983545006821 FixH; Region: FixH; pfam05751 983545006822 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 983545006823 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983545006824 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545006825 metal-binding site [ion binding] 983545006826 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983545006827 Soluble P-type ATPase [General function prediction only]; Region: COG4087 983545006828 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 983545006829 Family description; Region: DsbD_2; pfam13386 983545006830 universal stress protein UspE; Provisional; Region: PRK11175 983545006831 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006832 Ligand Binding Site [chemical binding]; other site 983545006833 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006834 Ligand Binding Site [chemical binding]; other site 983545006835 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545006836 FtsX-like permease family; Region: FtsX; pfam02687 983545006837 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 983545006838 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 983545006839 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983545006840 Walker A/P-loop; other site 983545006841 ATP binding site [chemical binding]; other site 983545006842 Q-loop/lid; other site 983545006843 ABC transporter signature motif; other site 983545006844 Walker B; other site 983545006845 D-loop; other site 983545006846 H-loop/switch region; other site 983545006847 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 983545006848 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 983545006849 Ligand Binding Site [chemical binding]; other site 983545006850 hypothetical protein; Provisional; Region: PRK10279 983545006851 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 983545006852 active site 983545006853 nucleophile elbow; other site 983545006854 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 983545006855 EamA-like transporter family; Region: EamA; pfam00892 983545006856 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 983545006857 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 983545006858 LysE type translocator; Region: LysE; cl00565 983545006859 NAD-dependent deacetylase; Provisional; Region: PRK00481 983545006860 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 983545006861 NAD+ binding site [chemical binding]; other site 983545006862 substrate binding site [chemical binding]; other site 983545006863 Zn binding site [ion binding]; other site 983545006864 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 983545006865 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 983545006866 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 983545006867 fumarate hydratase; Reviewed; Region: fumC; PRK00485 983545006868 Class II fumarases; Region: Fumarase_classII; cd01362 983545006869 active site 983545006870 tetramer interface [polypeptide binding]; other site 983545006871 indole-3-acetamide amidohydrolase; Region: PLN02722 983545006872 Amidase; Region: Amidase; cl11426 983545006873 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 983545006874 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983545006875 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545006876 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 983545006877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545006878 catalytic residue [active] 983545006879 allantoate amidohydrolase; Reviewed; Region: PRK09290 983545006880 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 983545006881 active site 983545006882 metal binding site [ion binding]; metal-binding site 983545006883 dimer interface [polypeptide binding]; other site 983545006884 Cupin domain; Region: Cupin_2; cl17218 983545006885 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 983545006886 glutaminase; Provisional; Region: PRK00971 983545006887 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 983545006888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545006889 Coenzyme A binding pocket [chemical binding]; other site 983545006890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 983545006891 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 983545006892 Walker A/P-loop; other site 983545006893 ATP binding site [chemical binding]; other site 983545006894 Q-loop/lid; other site 983545006895 ABC transporter signature motif; other site 983545006896 Walker B; other site 983545006897 D-loop; other site 983545006898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545006899 Walker A/P-loop; other site 983545006900 ATP binding site [chemical binding]; other site 983545006901 Q-loop/lid; other site 983545006902 ABC transporter signature motif; other site 983545006903 Walker B; other site 983545006904 D-loop; other site 983545006905 H-loop/switch region; other site 983545006906 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983545006907 MarR family; Region: MarR_2; pfam12802 983545006908 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 983545006909 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 983545006910 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 983545006911 homodimer interface [polypeptide binding]; other site 983545006912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006913 catalytic residue [active] 983545006914 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 983545006915 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 983545006916 trimer interface [polypeptide binding]; other site 983545006917 putative metal binding site [ion binding]; other site 983545006918 acyl-CoA thioesterase II; Provisional; Region: PRK10526 983545006919 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 983545006920 active site 983545006921 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 983545006922 catalytic triad [active] 983545006923 dimer interface [polypeptide binding]; other site 983545006924 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545006925 active site 983545006926 ATP binding site [chemical binding]; other site 983545006927 substrate binding site [chemical binding]; other site 983545006928 activation loop (A-loop); other site 983545006929 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 983545006930 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 983545006931 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545006932 E3 interaction surface; other site 983545006933 lipoyl attachment site [posttranslational modification]; other site 983545006934 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545006935 E3 interaction surface; other site 983545006936 lipoyl attachment site [posttranslational modification]; other site 983545006937 e3 binding domain; Region: E3_binding; pfam02817 983545006938 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 983545006939 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 983545006940 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 983545006941 alpha subunit interface [polypeptide binding]; other site 983545006942 TPP binding site [chemical binding]; other site 983545006943 heterodimer interface [polypeptide binding]; other site 983545006944 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983545006945 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 983545006946 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 983545006947 tetramer interface [polypeptide binding]; other site 983545006948 TPP-binding site [chemical binding]; other site 983545006949 heterodimer interface [polypeptide binding]; other site 983545006950 phosphorylation loop region [posttranslational modification] 983545006951 Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955 983545006952 aminotransferase AlaT; Validated; Region: PRK09265 983545006953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545006954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006955 homodimer interface [polypeptide binding]; other site 983545006956 catalytic residue [active] 983545006957 5'-nucleotidase; Provisional; Region: PRK03826 983545006958 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545006959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006960 NAD(P) binding site [chemical binding]; other site 983545006961 active site 983545006962 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 983545006963 putative active site [active] 983545006964 redox center [active] 983545006965 Trehalose utilisation; Region: ThuA; pfam06283 983545006966 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 983545006967 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545006968 Zn2+ binding site [ion binding]; other site 983545006969 Mg2+ binding site [ion binding]; other site 983545006970 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 983545006971 TMAO/DMSO reductase; Reviewed; Region: PRK05363 983545006972 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 983545006973 Moco binding site; other site 983545006974 metal coordination site [ion binding]; other site 983545006975 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 983545006976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 983545006977 SEC-C motif; Region: SEC-C; pfam02810 983545006978 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 983545006979 active site 1 [active] 983545006980 dimer interface [polypeptide binding]; other site 983545006981 active site 2 [active] 983545006982 Ribosome modulation factor; Region: RMF; pfam04957 983545006983 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 983545006984 ABC transporter ATPase component; Reviewed; Region: PRK11147 983545006985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545006986 Walker A/P-loop; other site 983545006987 ATP binding site [chemical binding]; other site 983545006988 Q-loop/lid; other site 983545006989 ABC transporter signature motif; other site 983545006990 Walker B; other site 983545006991 D-loop; other site 983545006992 H-loop/switch region; other site 983545006993 ABC transporter; Region: ABC_tran_2; pfam12848 983545006994 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545006995 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 983545006996 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 983545006997 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 983545006998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 983545006999 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 983545007000 putative RNA binding site [nucleotide binding]; other site 983545007001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545007002 S-adenosylmethionine binding site [chemical binding]; other site 983545007003 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 983545007004 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 983545007005 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 983545007006 quinone interaction residues [chemical binding]; other site 983545007007 active site 983545007008 catalytic residues [active] 983545007009 FMN binding site [chemical binding]; other site 983545007010 substrate binding site [chemical binding]; other site 983545007011 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 983545007012 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 983545007013 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545007014 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 983545007015 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545007016 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 983545007017 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 983545007018 aminopeptidase N; Provisional; Region: pepN; PRK14015 983545007019 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 983545007020 active site 983545007021 Zn binding site [ion binding]; other site 983545007022 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 983545007023 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 983545007024 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 983545007025 Na2 binding site [ion binding]; other site 983545007026 putative substrate binding site 1 [chemical binding]; other site 983545007027 Na binding site 1 [ion binding]; other site 983545007028 putative substrate binding site 2 [chemical binding]; other site 983545007029 carboxy-terminal protease; Provisional; Region: PRK11186 983545007030 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983545007031 protein binding site [polypeptide binding]; other site 983545007032 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 983545007033 Catalytic dyad [active] 983545007034 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 983545007035 ProP expression regulator; Provisional; Region: PRK04950 983545007036 ProQ/FINO family; Region: ProQ; pfam04352 983545007037 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 983545007038 GAF domain; Region: GAF_2; pfam13185 983545007039 Cytochrome C' Region: Cytochrom_C_2; pfam01322 983545007040 chaperone protein DnaJ; Provisional; Region: PRK10767 983545007041 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 983545007042 HSP70 interaction site [polypeptide binding]; other site 983545007043 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 983545007044 substrate binding site [polypeptide binding]; other site 983545007045 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 983545007046 Zn binding sites [ion binding]; other site 983545007047 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 983545007048 dimer interface [polypeptide binding]; other site 983545007049 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 983545007050 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 983545007051 nucleotide binding site [chemical binding]; other site 983545007052 GrpE; Region: GrpE; pfam01025 983545007053 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 983545007054 dimer interface [polypeptide binding]; other site 983545007055 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 983545007056 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 983545007057 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545007058 Na binding site [ion binding]; other site 983545007059 PAS domain; Region: PAS; smart00091 983545007060 PAS fold; Region: PAS_7; pfam12860 983545007061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545007062 dimer interface [polypeptide binding]; other site 983545007063 phosphorylation site [posttranslational modification] 983545007064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007065 ATP binding site [chemical binding]; other site 983545007066 Mg2+ binding site [ion binding]; other site 983545007067 G-X-G motif; other site 983545007068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007069 active site 983545007070 phosphorylation site [posttranslational modification] 983545007071 intermolecular recognition site; other site 983545007072 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 983545007073 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 983545007074 RDD family; Region: RDD; pfam06271 983545007075 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545007076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007077 active site 983545007078 phosphorylation site [posttranslational modification] 983545007079 intermolecular recognition site; other site 983545007080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983545007081 Transposase; Region: HTH_Tnp_1; pfam01527 983545007082 putative transposase OrfB; Reviewed; Region: PHA02517 983545007083 HTH-like domain; Region: HTH_21; pfam13276 983545007084 Integrase core domain; Region: rve; pfam00665 983545007085 Integrase core domain; Region: rve_3; pfam13683 983545007086 integron integrase; Region: integrase_gron; TIGR02249 983545007087 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 983545007088 Int/Topo IB signature motif; other site 983545007089 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 983545007090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545007091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007092 active site 983545007093 phosphorylation site [posttranslational modification] 983545007094 intermolecular recognition site; other site 983545007095 dimerization interface [polypeptide binding]; other site 983545007096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545007097 DNA binding residues [nucleotide binding] 983545007098 dimerization interface [polypeptide binding]; other site 983545007099 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545007100 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545007101 N-terminal plug; other site 983545007102 ligand-binding site [chemical binding]; other site 983545007103 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 983545007104 fructuronate transporter; Provisional; Region: PRK10034; cl15264 983545007105 homoserine O-acetyltransferase; Provisional; Region: PRK06765 983545007106 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 983545007107 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 983545007108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007109 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 983545007110 NAD(P) binding site [chemical binding]; other site 983545007111 active site 983545007112 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545007113 Phage Tail Collar Domain; Region: Collar; pfam07484 983545007114 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545007115 Phage Tail Collar Domain; Region: Collar; pfam07484 983545007116 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545007117 Phage Tail Collar Domain; Region: Collar; pfam07484 983545007118 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 983545007119 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 983545007120 dimer interface [polypeptide binding]; other site 983545007121 active site 983545007122 heme binding site [chemical binding]; other site 983545007123 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 983545007124 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 983545007125 Leucine-rich repeats; other site 983545007126 Substrate binding site [chemical binding]; other site 983545007127 Leucine rich repeat; Region: LRR_8; pfam13855 983545007128 Leucine rich repeat; Region: LRR_8; pfam13855 983545007129 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545007130 active site 983545007131 ATP binding site [chemical binding]; other site 983545007132 substrate binding site [chemical binding]; other site 983545007133 activation loop (A-loop); other site 983545007134 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 983545007135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983545007136 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 983545007137 Protein with unknown function (DUF469); Region: DUF469; pfam04320 983545007138 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 983545007139 carbohydrate binding site [chemical binding]; other site 983545007140 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 983545007141 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 983545007142 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 983545007143 Ca binding site [ion binding]; other site 983545007144 active site 983545007145 catalytic site [active] 983545007146 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 983545007147 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 983545007148 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 983545007149 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 983545007150 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545007151 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007152 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007153 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545007154 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545007155 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545007156 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007157 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007158 Cupin-like domain; Region: Cupin_8; pfam13621 983545007159 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 983545007160 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545007161 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 983545007162 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 983545007163 ATP binding site [chemical binding]; other site 983545007164 substrate interface [chemical binding]; other site 983545007165 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545007166 active site residue [active] 983545007167 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 983545007168 dimer interface [polypeptide binding]; other site 983545007169 substrate binding site [chemical binding]; other site 983545007170 ATP binding site [chemical binding]; other site 983545007171 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 983545007172 thiamine phosphate binding site [chemical binding]; other site 983545007173 active site 983545007174 pyrophosphate binding site [ion binding]; other site 983545007175 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 983545007176 ThiS interaction site; other site 983545007177 putative active site [active] 983545007178 tetramer interface [polypeptide binding]; other site 983545007179 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 983545007180 thiS-thiF/thiG interaction site; other site 983545007181 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 983545007182 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 983545007183 ThiC-associated domain; Region: ThiC-associated; pfam13667 983545007184 ThiC family; Region: ThiC; pfam01964 983545007185 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 983545007186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545007187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545007188 WHG domain; Region: WHG; pfam13305 983545007189 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545007190 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 983545007191 putative active site [active] 983545007192 putative FMN binding site [chemical binding]; other site 983545007193 putative substrate binding site [chemical binding]; other site 983545007194 putative catalytic residue [active] 983545007195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545007196 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545007197 putative substrate translocation pore; other site 983545007198 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 983545007199 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545007200 carboxyltransferase (CT) interaction site; other site 983545007201 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545007202 biotinylation site [posttranslational modification]; other site 983545007203 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545007204 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545007205 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545007206 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545007207 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545007208 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545007209 active site 983545007210 catalytic tetrad [active] 983545007211 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 983545007212 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545007213 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545007214 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545007215 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 983545007216 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 983545007217 putative [Fe4-S4] binding site [ion binding]; other site 983545007218 putative molybdopterin cofactor binding site [chemical binding]; other site 983545007219 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 983545007220 putative molybdopterin cofactor binding site; other site 983545007221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 983545007222 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 983545007223 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545007224 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545007225 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545007226 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983545007227 Walker A/P-loop; other site 983545007228 ATP binding site [chemical binding]; other site 983545007229 Q-loop/lid; other site 983545007230 ABC transporter signature motif; other site 983545007231 Walker B; other site 983545007232 D-loop; other site 983545007233 H-loop/switch region; other site 983545007234 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545007235 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 983545007236 FtsX-like permease family; Region: FtsX; pfam02687 983545007237 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545007238 FtsX-like permease family; Region: FtsX; pfam02687 983545007239 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 983545007240 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 983545007241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545007242 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545007243 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545007244 substrate binding site [chemical binding]; other site 983545007245 ATP binding site [chemical binding]; other site 983545007246 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545007247 active site 983545007248 Helix-turn-helix; Region: HTH_3; pfam01381 983545007249 non-specific DNA binding site [nucleotide binding]; other site 983545007250 salt bridge; other site 983545007251 sequence-specific DNA binding site [nucleotide binding]; other site 983545007252 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 983545007253 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 983545007254 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 983545007255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545007256 dimerization interface [polypeptide binding]; other site 983545007257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545007258 dimer interface [polypeptide binding]; other site 983545007259 putative CheW interface [polypeptide binding]; other site 983545007260 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007261 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007262 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007263 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545007264 SapC; Region: SapC; pfam07277 983545007265 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 983545007266 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 983545007267 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545007268 Bacterial transcriptional regulator; Region: IclR; pfam01614 983545007269 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545007270 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 983545007271 Protein of unknown function (DUF465); Region: DUF465; pfam04325 983545007272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007273 metal binding site [ion binding]; metal-binding site 983545007274 I-site; other site 983545007275 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545007276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007277 PAS domain; Region: PAS_9; pfam13426 983545007278 putative active site [active] 983545007279 heme pocket [chemical binding]; other site 983545007280 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545007281 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545007282 dimer interface [polypeptide binding]; other site 983545007283 putative CheW interface [polypeptide binding]; other site 983545007284 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 983545007285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007286 active site 983545007287 phosphorylation site [posttranslational modification] 983545007288 intermolecular recognition site; other site 983545007289 dimerization interface [polypeptide binding]; other site 983545007290 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545007291 Zn2+ binding site [ion binding]; other site 983545007292 Mg2+ binding site [ion binding]; other site 983545007293 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 983545007294 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545007295 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545007296 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545007297 PAS domain S-box; Region: sensory_box; TIGR00229 983545007298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007299 putative active site [active] 983545007300 heme pocket [chemical binding]; other site 983545007301 PAS domain S-box; Region: sensory_box; TIGR00229 983545007302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007303 putative active site [active] 983545007304 heme pocket [chemical binding]; other site 983545007305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545007306 dimer interface [polypeptide binding]; other site 983545007307 phosphorylation site [posttranslational modification] 983545007308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007309 ATP binding site [chemical binding]; other site 983545007310 Mg2+ binding site [ion binding]; other site 983545007311 G-X-G motif; other site 983545007312 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545007313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007314 active site 983545007315 phosphorylation site [posttranslational modification] 983545007316 intermolecular recognition site; other site 983545007317 dimerization interface [polypeptide binding]; other site 983545007318 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545007319 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 983545007320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007321 active site 983545007322 phosphorylation site [posttranslational modification] 983545007323 intermolecular recognition site; other site 983545007324 dimerization interface [polypeptide binding]; other site 983545007325 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545007326 DNA binding site [nucleotide binding] 983545007327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545007328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545007329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545007330 dimer interface [polypeptide binding]; other site 983545007331 phosphorylation site [posttranslational modification] 983545007332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007333 ATP binding site [chemical binding]; other site 983545007334 Mg2+ binding site [ion binding]; other site 983545007335 G-X-G motif; other site 983545007336 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545007337 GAF domain; Region: GAF; pfam01590 983545007338 GAF domain; Region: GAF; pfam01590 983545007339 GAF domain; Region: GAF_2; pfam13185 983545007340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545007341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007342 metal binding site [ion binding]; metal-binding site 983545007343 active site 983545007344 I-site; other site 983545007345 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545007346 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 983545007347 MarR family; Region: MarR_2; pfam12802 983545007348 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545007349 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545007350 active site 983545007351 catalytic tetrad [active] 983545007352 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545007353 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545007354 hypothetical protein; Provisional; Region: PRK11281 983545007355 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 983545007356 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545007357 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545007358 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545007359 N-terminal plug; other site 983545007360 ligand-binding site [chemical binding]; other site 983545007361 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 983545007362 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 983545007363 FAD binding pocket [chemical binding]; other site 983545007364 FAD binding motif [chemical binding]; other site 983545007365 phosphate binding motif [ion binding]; other site 983545007366 NAD binding pocket [chemical binding]; other site 983545007367 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 983545007368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545007369 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 983545007370 non-specific DNA binding site [nucleotide binding]; other site 983545007371 salt bridge; other site 983545007372 sequence-specific DNA binding site [nucleotide binding]; other site 983545007373 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 983545007374 TrkA-N domain; Region: TrkA_N; pfam02254 983545007375 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545007376 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 983545007377 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 983545007378 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 983545007379 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 983545007380 active site 983545007381 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545007382 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 983545007383 C-terminal domain interface [polypeptide binding]; other site 983545007384 GSH binding site (G-site) [chemical binding]; other site 983545007385 dimer interface [polypeptide binding]; other site 983545007386 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545007387 N-terminal domain interface [polypeptide binding]; other site 983545007388 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 983545007389 fructuronate transporter; Provisional; Region: PRK10034; cl15264 983545007390 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 983545007391 homotrimer interaction site [polypeptide binding]; other site 983545007392 putative active site [active] 983545007393 Part of AAA domain; Region: AAA_19; pfam13245 983545007394 Family description; Region: UvrD_C_2; pfam13538 983545007395 Predicted membrane protein [Function unknown]; Region: COG2323 983545007396 UPF0126 domain; Region: UPF0126; pfam03458 983545007397 Predicted membrane protein [Function unknown]; Region: COG2860 983545007398 UPF0126 domain; Region: UPF0126; pfam03458 983545007399 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983545007400 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545007401 PAS domain; Region: PAS; smart00091 983545007402 PAS domain S-box; Region: sensory_box; TIGR00229 983545007403 putative active site [active] 983545007404 heme pocket [chemical binding]; other site 983545007405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007406 PAS fold; Region: PAS_3; pfam08447 983545007407 putative active site [active] 983545007408 heme pocket [chemical binding]; other site 983545007409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 983545007410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545007411 dimer interface [polypeptide binding]; other site 983545007412 phosphorylation site [posttranslational modification] 983545007413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007414 ATP binding site [chemical binding]; other site 983545007415 Mg2+ binding site [ion binding]; other site 983545007416 G-X-G motif; other site 983545007417 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007419 active site 983545007420 phosphorylation site [posttranslational modification] 983545007421 intermolecular recognition site; other site 983545007422 dimerization interface [polypeptide binding]; other site 983545007423 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 983545007424 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 983545007425 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 983545007426 active site 983545007427 substrate binding site [chemical binding]; other site 983545007428 FMN binding site [chemical binding]; other site 983545007429 putative catalytic residues [active] 983545007430 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 983545007431 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545007432 N-terminal plug; other site 983545007433 ligand-binding site [chemical binding]; other site 983545007434 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 983545007435 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 983545007436 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 983545007437 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 983545007438 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 983545007439 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545007440 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545007441 FAD binding domain; Region: FAD_binding_4; pfam01565 983545007442 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 983545007443 Cysteine-rich domain; Region: CCG; pfam02754 983545007444 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 983545007445 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 983545007446 active site 983545007447 substrate-binding site [chemical binding]; other site 983545007448 metal-binding site [ion binding] 983545007449 ATP binding site [chemical binding]; other site 983545007450 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 983545007451 SnoaL-like domain; Region: SnoaL_2; pfam12680 983545007452 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007453 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007454 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007455 Cupin domain; Region: Cupin_2; cl17218 983545007456 Cupin domain; Region: Cupin_2; pfam07883 983545007457 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545007458 classical (c) SDRs; Region: SDR_c; cd05233 983545007459 NAD(P) binding site [chemical binding]; other site 983545007460 active site 983545007461 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 983545007462 histidinol dehydrogenase; Region: hisD; TIGR00069 983545007463 NAD binding site [chemical binding]; other site 983545007464 dimerization interface [polypeptide binding]; other site 983545007465 product binding site; other site 983545007466 substrate binding site [chemical binding]; other site 983545007467 zinc binding site [ion binding]; other site 983545007468 catalytic residues [active] 983545007469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545007470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545007471 DNA binding site [nucleotide binding] 983545007472 domain linker motif; other site 983545007473 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 983545007474 putative dimerization interface [polypeptide binding]; other site 983545007475 putative ligand binding site [chemical binding]; other site 983545007476 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545007477 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 983545007478 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545007479 Ligand Binding Site [chemical binding]; other site 983545007480 AAA domain; Region: AAA_22; pfam13401 983545007481 Predicted kinase [General function prediction only]; Region: COG0645 983545007482 AAA domain; Region: AAA_17; pfam13207 983545007483 SnoaL-like domain; Region: SnoaL_2; pfam12680 983545007484 SnoaL-like domain; Region: SnoaL_2; pfam12680 983545007485 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 983545007486 Na binding site [ion binding]; other site 983545007487 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007488 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007489 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007490 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545007491 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545007492 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 983545007493 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 983545007494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545007495 Coenzyme A binding pocket [chemical binding]; other site 983545007496 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545007497 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545007498 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 983545007499 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 983545007500 FAD binding pocket [chemical binding]; other site 983545007501 FAD binding motif [chemical binding]; other site 983545007502 phosphate binding motif [ion binding]; other site 983545007503 beta-alpha-beta structure motif; other site 983545007504 NAD binding pocket [chemical binding]; other site 983545007505 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 983545007506 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 983545007507 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 983545007508 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 983545007509 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 983545007510 cofactor binding site; other site 983545007511 DNA binding site [nucleotide binding] 983545007512 substrate interaction site [chemical binding]; other site 983545007513 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 983545007514 Uncharacterized conserved protein [Function unknown]; Region: COG1479 983545007515 Protein of unknown function DUF262; Region: DUF262; pfam03235 983545007516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545007517 AAA domain; Region: AAA_23; pfam13476 983545007518 Walker A/P-loop; other site 983545007519 ATP binding site [chemical binding]; other site 983545007520 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545007521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007522 active site 983545007523 phosphorylation site [posttranslational modification] 983545007524 intermolecular recognition site; other site 983545007525 dimerization interface [polypeptide binding]; other site 983545007526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545007527 DNA binding residues [nucleotide binding] 983545007528 dimerization interface [polypeptide binding]; other site 983545007529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 983545007530 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 983545007531 Histidine kinase; Region: HisKA_3; pfam07730 983545007532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007533 ATP binding site [chemical binding]; other site 983545007534 Mg2+ binding site [ion binding]; other site 983545007535 G-X-G motif; other site 983545007536 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 983545007537 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 983545007538 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 983545007539 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 983545007540 DctM-like transporters; Region: DctM; pfam06808 983545007541 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007542 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 983545007543 Cytochrome b562; Region: Cytochrom_B562; cl01546 983545007544 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 983545007545 E-class dimer interface [polypeptide binding]; other site 983545007546 P-class dimer interface [polypeptide binding]; other site 983545007547 active site 983545007548 Cu2+ binding site [ion binding]; other site 983545007549 Zn2+ binding site [ion binding]; other site 983545007550 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 983545007551 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 983545007552 dimer interface [polypeptide binding]; other site 983545007553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545007554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007555 active site 983545007556 phosphorylation site [posttranslational modification] 983545007557 intermolecular recognition site; other site 983545007558 dimerization interface [polypeptide binding]; other site 983545007559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545007560 DNA binding site [nucleotide binding] 983545007561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545007562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545007563 dimer interface [polypeptide binding]; other site 983545007564 phosphorylation site [posttranslational modification] 983545007565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007566 ATP binding site [chemical binding]; other site 983545007567 Mg2+ binding site [ion binding]; other site 983545007568 G-X-G motif; other site 983545007569 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 983545007570 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545007571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545007572 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 983545007573 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545007574 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 983545007575 Cytochrome P450; Region: p450; cl12078 983545007576 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545007577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545007578 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 983545007579 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 983545007580 NAD binding site [chemical binding]; other site 983545007581 catalytic Zn binding site [ion binding]; other site 983545007582 substrate binding site [chemical binding]; other site 983545007583 structural Zn binding site [ion binding]; other site 983545007584 Putative esterase; Region: Esterase; pfam00756 983545007585 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 983545007586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 983545007587 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 983545007588 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545007589 Catalytic site [active] 983545007590 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545007591 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545007592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545007593 binding surface 983545007594 TPR motif; other site 983545007595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545007596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545007597 binding surface 983545007598 TPR motif; other site 983545007599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545007600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545007601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007602 metal binding site [ion binding]; metal-binding site 983545007603 active site 983545007604 I-site; other site 983545007605 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 983545007606 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545007607 NADP binding site [chemical binding]; other site 983545007608 dimer interface [polypeptide binding]; other site 983545007609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545007611 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545007612 putative effector binding pocket; other site 983545007613 dimerization interface [polypeptide binding]; other site 983545007614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545007615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545007616 DNA binding site [nucleotide binding] 983545007617 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 983545007618 putative active site [active] 983545007619 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 983545007620 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545007621 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545007622 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 983545007623 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 983545007624 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983545007625 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545007626 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 983545007627 Cupin domain; Region: Cupin_2; pfam07883 983545007628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007629 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 983545007630 NAD(P) binding site [chemical binding]; other site 983545007631 active site 983545007632 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545007633 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 983545007634 Na binding site [ion binding]; other site 983545007635 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 983545007636 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545007637 Bacterial transcriptional regulator; Region: IclR; pfam01614 983545007638 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 983545007639 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983545007640 active site 983545007641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545007642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545007643 putative substrate translocation pore; other site 983545007644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545007645 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545007646 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545007647 ATP binding site [chemical binding]; other site 983545007648 Mg++ binding site [ion binding]; other site 983545007649 motif III; other site 983545007650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545007651 nucleotide binding region [chemical binding]; other site 983545007652 ATP-binding site [chemical binding]; other site 983545007653 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545007654 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545007655 N-terminal plug; other site 983545007656 ligand-binding site [chemical binding]; other site 983545007657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545007659 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545007660 dimerization interface [polypeptide binding]; other site 983545007661 substrate binding pocket [chemical binding]; other site 983545007662 hypothetical protein; Provisional; Region: PRK06208 983545007663 intersubunit interface [polypeptide binding]; other site 983545007664 active site 983545007665 Zn2+ binding site [ion binding]; other site 983545007666 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 983545007667 putative active site [active] 983545007668 Zn binding site [ion binding]; other site 983545007669 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 983545007670 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 983545007671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 983545007672 Zn2+ binding site [ion binding]; other site 983545007673 Mg2+ binding site [ion binding]; other site 983545007674 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 983545007675 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545007676 conserved hypothetical protein; Region: TIGR02285 983545007677 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 983545007678 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 983545007679 CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY. CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598 983545007680 putative active site [active] 983545007681 putative catalytic site [active] 983545007682 Putative esterase; Region: Esterase; pfam00756 983545007683 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 983545007684 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 983545007685 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545007686 active site 983545007687 catalytic site [active] 983545007688 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 983545007689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 983545007690 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 983545007691 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 983545007692 DNA binding residues [nucleotide binding] 983545007693 putative dimer interface [polypeptide binding]; other site 983545007694 putative metal binding residues [ion binding]; other site 983545007695 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 983545007696 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 983545007697 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 983545007698 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 983545007699 GIY-YIG motif/motif A; other site 983545007700 active site 983545007701 catalytic site [active] 983545007702 putative DNA binding site [nucleotide binding]; other site 983545007703 metal binding site [ion binding]; metal-binding site 983545007704 UvrB/uvrC motif; Region: UVR; pfam02151 983545007705 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 983545007706 response regulator; Provisional; Region: PRK09483 983545007707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007708 active site 983545007709 phosphorylation site [posttranslational modification] 983545007710 intermolecular recognition site; other site 983545007711 dimerization interface [polypeptide binding]; other site 983545007712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545007713 DNA binding residues [nucleotide binding] 983545007714 dimerization interface [polypeptide binding]; other site 983545007715 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 983545007716 YccA-like proteins; Region: YccA_like; cd10433 983545007717 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 983545007718 DsrE/DsrF-like family; Region: DrsE; cl00672 983545007719 DsrH like protein; Region: DsrH; cl17347 983545007720 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 983545007721 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 983545007722 seryl-tRNA synthetase; Provisional; Region: PRK05431 983545007723 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 983545007724 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 983545007725 dimer interface [polypeptide binding]; other site 983545007726 active site 983545007727 motif 1; other site 983545007728 motif 2; other site 983545007729 motif 3; other site 983545007730 CrcB-like protein; Region: CRCB; cl09114 983545007731 recombination factor protein RarA; Reviewed; Region: PRK13342 983545007732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545007733 Walker A motif; other site 983545007734 ATP binding site [chemical binding]; other site 983545007735 Walker B motif; other site 983545007736 arginine finger; other site 983545007737 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 983545007738 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 983545007739 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 983545007740 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 983545007741 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 983545007742 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 983545007743 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 983545007744 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 983545007745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545007746 putative DNA binding site [nucleotide binding]; other site 983545007747 putative Zn2+ binding site [ion binding]; other site 983545007748 AsnC family; Region: AsnC_trans_reg; pfam01037 983545007749 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 983545007750 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 983545007751 hexamer interface [polypeptide binding]; other site 983545007752 ligand binding site [chemical binding]; other site 983545007753 putative active site [active] 983545007754 NAD(P) binding site [chemical binding]; other site 983545007755 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 983545007756 active site 983545007757 dimer interface [polypeptide binding]; other site 983545007758 tetratricopeptide repeat protein; Provisional; Region: PRK11788 983545007759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545007760 binding surface 983545007761 TPR motif; other site 983545007762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545007763 binding surface 983545007764 TPR motif; other site 983545007765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545007766 binding surface 983545007767 TPR motif; other site 983545007768 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 983545007769 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983545007770 IHF dimer interface [polypeptide binding]; other site 983545007771 IHF - DNA interface [nucleotide binding]; other site 983545007772 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 983545007773 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 983545007774 RNA binding site [nucleotide binding]; other site 983545007775 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 983545007776 RNA binding site [nucleotide binding]; other site 983545007777 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 983545007778 RNA binding site [nucleotide binding]; other site 983545007779 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 983545007780 RNA binding site [nucleotide binding]; other site 983545007781 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 983545007782 RNA binding site [nucleotide binding]; other site 983545007783 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 983545007784 RNA binding site [nucleotide binding]; other site 983545007785 cytidylate kinase; Provisional; Region: cmk; PRK00023 983545007786 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 983545007787 CMP-binding site; other site 983545007788 The sites determining sugar specificity; other site 983545007789 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 983545007790 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 983545007791 hinge; other site 983545007792 active site 983545007793 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 983545007794 homodimer interface [polypeptide binding]; other site 983545007795 substrate-cofactor binding pocket; other site 983545007796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545007797 catalytic residue [active] 983545007798 DNA gyrase subunit A; Validated; Region: PRK05560 983545007799 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 983545007800 CAP-like domain; other site 983545007801 active site 983545007802 primary dimer interface [polypeptide binding]; other site 983545007803 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007804 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007805 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007806 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007807 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007808 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007809 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 983545007810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545007811 S-adenosylmethionine binding site [chemical binding]; other site 983545007812 phosphoglycolate phosphatase; Provisional; Region: PRK13226 983545007813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545007814 motif II; other site 983545007815 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 983545007816 ATP cone domain; Region: ATP-cone; pfam03477 983545007817 Class I ribonucleotide reductase; Region: RNR_I; cd01679 983545007818 active site 983545007819 dimer interface [polypeptide binding]; other site 983545007820 catalytic residues [active] 983545007821 effector binding site; other site 983545007822 R2 peptide binding site; other site 983545007823 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 983545007824 dimer interface [polypeptide binding]; other site 983545007825 putative radical transfer pathway; other site 983545007826 diiron center [ion binding]; other site 983545007827 tyrosyl radical; other site 983545007828 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 983545007829 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545007830 catalytic loop [active] 983545007831 iron binding site [ion binding]; other site 983545007832 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545007833 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545007834 active site 983545007835 dimer interface [polypeptide binding]; other site 983545007836 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983545007837 Ligand Binding Site [chemical binding]; other site 983545007838 Molecular Tunnel; other site 983545007839 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 983545007840 ATP binding site [chemical binding]; other site 983545007841 active site 983545007842 substrate binding site [chemical binding]; other site 983545007843 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 983545007844 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 983545007845 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 983545007846 dihydrodipicolinate synthase; Region: dapA; TIGR00674 983545007847 dimer interface [polypeptide binding]; other site 983545007848 active site 983545007849 catalytic residue [active] 983545007850 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 983545007851 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545007852 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545007853 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 983545007854 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 983545007855 catalytic triad [active] 983545007856 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 983545007857 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983545007858 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 983545007859 Peptidase family M48; Region: Peptidase_M48; pfam01435 983545007860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545007861 binding surface 983545007862 TPR motif; other site 983545007863 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983545007864 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983545007865 catalytic residues [active] 983545007866 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 983545007867 ArsC family; Region: ArsC; pfam03960 983545007868 catalytic residues [active] 983545007869 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 983545007870 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 983545007871 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 983545007872 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 983545007873 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 983545007874 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 983545007875 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 983545007876 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 983545007877 dimerization interface [polypeptide binding]; other site 983545007878 putative ATP binding site [chemical binding]; other site 983545007879 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 983545007880 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 983545007881 active site 983545007882 substrate binding site [chemical binding]; other site 983545007883 cosubstrate binding site; other site 983545007884 catalytic site [active] 983545007885 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 983545007886 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 983545007887 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 983545007888 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545007889 active site 983545007890 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 983545007891 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983545007892 IHF dimer interface [polypeptide binding]; other site 983545007893 IHF - DNA interface [nucleotide binding]; other site 983545007894 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 983545007895 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 983545007896 putative tRNA-binding site [nucleotide binding]; other site 983545007897 B3/4 domain; Region: B3_4; pfam03483 983545007898 tRNA synthetase B5 domain; Region: B5; smart00874 983545007899 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 983545007900 dimer interface [polypeptide binding]; other site 983545007901 motif 1; other site 983545007902 motif 3; other site 983545007903 motif 2; other site 983545007904 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 983545007905 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 983545007906 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 983545007907 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 983545007908 dimer interface [polypeptide binding]; other site 983545007909 motif 1; other site 983545007910 active site 983545007911 motif 2; other site 983545007912 motif 3; other site 983545007913 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 983545007914 23S rRNA binding site [nucleotide binding]; other site 983545007915 L21 binding site [polypeptide binding]; other site 983545007916 L13 binding site [polypeptide binding]; other site 983545007917 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 983545007918 translation initiation factor IF-3; Region: infC; TIGR00168 983545007919 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 983545007920 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 983545007921 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 983545007922 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 983545007923 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 983545007924 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 983545007925 active site 983545007926 dimer interface [polypeptide binding]; other site 983545007927 motif 1; other site 983545007928 motif 2; other site 983545007929 motif 3; other site 983545007930 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 983545007931 anticodon binding site; other site 983545007932 pteridine reductase; Provisional; Region: PRK09135 983545007933 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 983545007934 NADP binding site [chemical binding]; other site 983545007935 substrate binding pocket [chemical binding]; other site 983545007936 active site 983545007937 Protein of unknown function (DUF3080); Region: DUF3080; pfam11279 983545007938 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 983545007939 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545007940 active site 983545007941 catalytic site [active] 983545007942 substrate binding site [chemical binding]; other site 983545007943 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 983545007944 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545007945 ligand binding site [chemical binding]; other site 983545007946 flexible hinge region; other site 983545007947 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 983545007948 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545007949 metal binding triad; other site 983545007950 BCCT family transporter; Region: BCCT; pfam02028 983545007951 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 983545007952 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545007953 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 983545007954 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 983545007955 active site 983545007956 catalytic residues [active] 983545007957 DNA binding site [nucleotide binding] 983545007958 Int/Topo IB signature motif; other site 983545007959 potential frameshift: common BLAST hit: gi|209397642|ref|YP_002271427.1| phage portal protein, lambda family 983545007960 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 983545007961 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 983545007962 oligomer interface [polypeptide binding]; other site 983545007963 active site residues [active] 983545007964 HIRAN domain; Region: HIRAN; cl07418 983545007965 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 983545007966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545007967 active site 983545007968 phosphorylation site [posttranslational modification] 983545007969 intermolecular recognition site; other site 983545007970 dimerization interface [polypeptide binding]; other site 983545007971 CheB methylesterase; Region: CheB_methylest; pfam01339 983545007972 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487 983545007973 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 983545007974 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 983545007975 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 983545007976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007977 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545007978 putative active site [active] 983545007979 heme pocket [chemical binding]; other site 983545007980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007981 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545007982 putative active site [active] 983545007983 heme pocket [chemical binding]; other site 983545007984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007985 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545007986 putative active site [active] 983545007987 heme pocket [chemical binding]; other site 983545007988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007989 putative active site [active] 983545007990 heme pocket [chemical binding]; other site 983545007991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545007992 dimer interface [polypeptide binding]; other site 983545007993 putative CheW interface [polypeptide binding]; other site 983545007994 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 983545007995 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 983545007996 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545007997 putative binding surface; other site 983545007998 active site 983545007999 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 983545008000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008001 ATP binding site [chemical binding]; other site 983545008002 Mg2+ binding site [ion binding]; other site 983545008003 G-X-G motif; other site 983545008004 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 983545008005 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008007 active site 983545008008 phosphorylation site [posttranslational modification] 983545008009 intermolecular recognition site; other site 983545008010 dimerization interface [polypeptide binding]; other site 983545008011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008012 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008013 active site 983545008014 phosphorylation site [posttranslational modification] 983545008015 intermolecular recognition site; other site 983545008016 dimerization interface [polypeptide binding]; other site 983545008017 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 983545008018 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 983545008019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545008020 ATP binding site [chemical binding]; other site 983545008021 Mg2+ binding site [ion binding]; other site 983545008022 G-X-G motif; other site 983545008023 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545008024 anti sigma factor interaction site; other site 983545008025 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545008026 regulatory phosphorylation site [posttranslational modification]; other site 983545008027 Uncharacterized conserved protein [Function unknown]; Region: COG3603 983545008028 Family description; Region: ACT_7; pfam13840 983545008029 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 983545008030 HPr interaction site; other site 983545008031 glycerol kinase (GK) interaction site [polypeptide binding]; other site 983545008032 active site 983545008033 phosphorylation site [posttranslational modification] 983545008034 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545008035 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 983545008036 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545008037 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 983545008038 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545008039 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545008040 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 983545008041 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545008042 catalytic loop [active] 983545008043 iron binding site [ion binding]; other site 983545008044 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545008045 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 983545008046 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 983545008047 Ligand binding site; other site 983545008048 metal-binding site 983545008049 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 983545008050 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 983545008051 XdhC Rossmann domain; Region: XdhC_C; pfam13478 983545008052 RDD family; Region: RDD; pfam06271 983545008053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 983545008054 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 983545008055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545008056 Walker A motif; other site 983545008057 ATP binding site [chemical binding]; other site 983545008058 Walker B motif; other site 983545008059 arginine finger; other site 983545008060 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 983545008061 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 983545008062 dimer interface [polypeptide binding]; other site 983545008063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545008064 catalytic residue [active] 983545008065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 983545008066 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 983545008067 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 983545008068 Uncharacterized conserved protein [Function unknown]; Region: COG3791 983545008069 CsbD-like; Region: CsbD; cl17424 983545008070 Protein of unknown function (DUF419); Region: DUF419; pfam04237 983545008071 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 983545008072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545008073 active site 983545008074 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 983545008075 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545008076 PilZ domain; Region: PilZ; pfam07238 983545008077 transcription-repair coupling factor; Provisional; Region: PRK10689 983545008078 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 983545008079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545008080 ATP binding site [chemical binding]; other site 983545008081 putative Mg++ binding site [ion binding]; other site 983545008082 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545008083 nucleotide binding region [chemical binding]; other site 983545008084 ATP-binding site [chemical binding]; other site 983545008085 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 983545008086 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545008087 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545008088 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545008089 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545008090 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545008091 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545008092 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 983545008093 homotrimer interaction site [polypeptide binding]; other site 983545008094 putative active site [active] 983545008095 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 983545008096 Cytochrome c; Region: Cytochrom_C; cl11414 983545008097 Cytochrome c; Region: Cytochrom_C; cl11414 983545008098 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 983545008099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545008101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008102 dimerization interface [polypeptide binding]; other site 983545008103 Domain of unknown function (DUF1805); Region: DUF1805; pfam08827 983545008104 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 983545008105 transmembrane helices; other site 983545008106 Citrate transporter; Region: CitMHS; pfam03600 983545008107 beta-hexosaminidase; Provisional; Region: PRK05337 983545008108 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 983545008109 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 983545008110 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 983545008111 recombination and repair protein; Provisional; Region: PRK10869 983545008112 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 983545008113 Walker A/P-loop; other site 983545008114 ATP binding site [chemical binding]; other site 983545008115 Q-loop/lid; other site 983545008116 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 983545008117 ABC transporter signature motif; other site 983545008118 Walker B; other site 983545008119 D-loop; other site 983545008120 H-loop/switch region; other site 983545008121 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 983545008122 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 983545008123 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 983545008124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545008125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545008126 Walker A/P-loop; other site 983545008127 ATP binding site [chemical binding]; other site 983545008128 Q-loop/lid; other site 983545008129 ABC transporter signature motif; other site 983545008130 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545008131 Walker B; other site 983545008132 D-loop; other site 983545008133 ABC transporter; Region: ABC_tran_2; pfam12848 983545008134 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545008135 Uncharacterized conserved protein [Function unknown]; Region: COG1432 983545008136 LabA_like proteins; Region: LabA_like/DUF88; cl10034 983545008137 putative metal binding site [ion binding]; other site 983545008138 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 983545008139 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 983545008140 G1 box; other site 983545008141 GTP/Mg2+ binding site [chemical binding]; other site 983545008142 G2 box; other site 983545008143 Switch I region; other site 983545008144 G3 box; other site 983545008145 Switch II region; other site 983545008146 G4 box; other site 983545008147 G5 box; other site 983545008148 Nucleoside recognition; Region: Gate; pfam07670 983545008149 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 983545008150 Nucleoside recognition; Region: Gate; pfam07670 983545008151 FeoA domain; Region: FeoA; pfam04023 983545008152 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 983545008153 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 983545008154 Low molecular weight phosphatase family; Region: LMWPc; cd00115 983545008155 active site 983545008156 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 983545008157 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545008158 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545008159 paraquat-inducible protein B; Provisional; Region: PRK10807 983545008160 mce related protein; Region: MCE; pfam02470 983545008161 mce related protein; Region: MCE; pfam02470 983545008162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 983545008163 Protein of unknown function (DUF330); Region: DUF330; pfam03886 983545008164 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 983545008165 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545008166 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008167 metal binding site [ion binding]; metal-binding site 983545008168 active site 983545008169 I-site; other site 983545008170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983545008171 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 983545008172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545008173 Walker A/P-loop; other site 983545008174 ATP binding site [chemical binding]; other site 983545008175 Q-loop/lid; other site 983545008176 ABC transporter signature motif; other site 983545008177 Walker B; other site 983545008178 D-loop; other site 983545008179 H-loop/switch region; other site 983545008180 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 983545008181 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 983545008182 16S/18S rRNA binding site [nucleotide binding]; other site 983545008183 S13e-L30e interaction site [polypeptide binding]; other site 983545008184 25S rRNA binding site [nucleotide binding]; other site 983545008185 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 983545008186 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 983545008187 RNA binding site [nucleotide binding]; other site 983545008188 active site 983545008189 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 983545008190 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 983545008191 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 983545008192 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 983545008193 translation initiation factor IF-2; Region: IF-2; TIGR00487 983545008194 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 983545008195 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 983545008196 G1 box; other site 983545008197 putative GEF interaction site [polypeptide binding]; other site 983545008198 GTP/Mg2+ binding site [chemical binding]; other site 983545008199 Switch I region; other site 983545008200 G2 box; other site 983545008201 G3 box; other site 983545008202 Switch II region; other site 983545008203 G4 box; other site 983545008204 G5 box; other site 983545008205 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 983545008206 Translation-initiation factor 2; Region: IF-2; pfam11987 983545008207 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 983545008208 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 983545008209 NusA N-terminal domain; Region: NusA_N; pfam08529 983545008210 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 983545008211 RNA binding site [nucleotide binding]; other site 983545008212 homodimer interface [polypeptide binding]; other site 983545008213 NusA-like KH domain; Region: KH_5; pfam13184 983545008214 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 983545008215 G-X-X-G motif; other site 983545008216 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 983545008217 ribosome maturation protein RimP; Reviewed; Region: PRK00092 983545008218 Sm and related proteins; Region: Sm_like; cl00259 983545008219 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 983545008220 putative oligomer interface [polypeptide binding]; other site 983545008221 putative RNA binding site [nucleotide binding]; other site 983545008222 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 983545008223 aromatic arch; other site 983545008224 DCoH dimer interaction site [polypeptide binding]; other site 983545008225 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 983545008226 DCoH tetramer interaction site [polypeptide binding]; other site 983545008227 substrate binding site [chemical binding]; other site 983545008228 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545008229 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545008230 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545008231 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545008232 active site 2 [active] 983545008233 active site 1 [active] 983545008234 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983545008235 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545008236 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 983545008237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545008238 active site 983545008239 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 983545008240 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983545008241 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545008242 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545008243 catalytic residue [active] 983545008244 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 983545008245 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 983545008246 active site pocket [active] 983545008247 aldolase II superfamily protein; Provisional; Region: PRK07044 983545008248 active site 983545008249 intersubunit interface [polypeptide binding]; other site 983545008250 Zn2+ binding site [ion binding]; other site 983545008251 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 983545008252 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 983545008253 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545008254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545008255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008256 metal binding site [ion binding]; metal-binding site 983545008257 active site 983545008258 I-site; other site 983545008259 Predicted acyltransferase [General function prediction only]; Region: COG4801 983545008260 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 983545008261 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 983545008262 putative metal binding site [ion binding]; other site 983545008263 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983545008264 Interdomain contacts; other site 983545008265 Predicted membrane protein [Function unknown]; Region: COG2259 983545008266 Pirin-related protein [General function prediction only]; Region: COG1741 983545008267 Pirin; Region: Pirin; pfam02678 983545008268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545008269 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 983545008270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008271 dimerization interface [polypeptide binding]; other site 983545008272 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545008273 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545008274 NAD(P) binding site [chemical binding]; other site 983545008275 substrate binding site [chemical binding]; other site 983545008276 dimer interface [polypeptide binding]; other site 983545008277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545008279 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008280 putative effector binding pocket; other site 983545008281 dimerization interface [polypeptide binding]; other site 983545008282 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 983545008283 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 983545008284 phosphate binding site [ion binding]; other site 983545008285 putative substrate binding pocket [chemical binding]; other site 983545008286 dimer interface [polypeptide binding]; other site 983545008287 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; pfam07073 983545008288 signal recognition particle protein; Provisional; Region: PRK10867 983545008289 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 983545008290 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 983545008291 P loop; other site 983545008292 GTP binding site [chemical binding]; other site 983545008293 Signal peptide binding domain; Region: SRP_SPB; pfam02978 983545008294 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545008295 hypothetical protein; Provisional; Region: PRK11573 983545008296 Domain of unknown function DUF21; Region: DUF21; pfam01595 983545008297 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545008298 Transporter associated domain; Region: CorC_HlyC; smart01091 983545008299 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 983545008300 catalytic core [active] 983545008301 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 983545008302 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545008303 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545008304 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545008305 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 983545008306 PAS fold; Region: PAS_3; pfam08447 983545008307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545008308 PAS domain; Region: PAS_9; pfam13426 983545008309 putative active site [active] 983545008310 heme pocket [chemical binding]; other site 983545008311 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545008312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008313 metal binding site [ion binding]; metal-binding site 983545008314 active site 983545008315 I-site; other site 983545008316 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545008317 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545008318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545008319 substrate binding site [chemical binding]; other site 983545008320 oxyanion hole (OAH) forming residues; other site 983545008321 trimer interface [polypeptide binding]; other site 983545008322 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983545008323 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545008324 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 983545008325 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545008326 dimer interface [polypeptide binding]; other site 983545008327 active site 983545008328 MoxR-like ATPases [General function prediction only]; Region: COG0714 983545008329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545008330 Walker A motif; other site 983545008331 ATP binding site [chemical binding]; other site 983545008332 Walker B motif; other site 983545008333 arginine finger; other site 983545008334 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 983545008335 Protein of unknown function DUF58; Region: DUF58; pfam01882 983545008336 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 983545008337 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 983545008338 metal ion-dependent adhesion site (MIDAS); other site 983545008339 von Willebrand factor type A domain; Region: VWA_2; pfam13519 983545008340 metal ion-dependent adhesion site (MIDAS); other site 983545008341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545008342 TPR repeat; Region: TPR_11; pfam13414 983545008343 Oxygen tolerance; Region: BatD; pfam13584 983545008344 RNA polymerase sigma factor; Provisional; Region: PRK12517 983545008345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545008346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545008347 DNA binding residues [nucleotide binding] 983545008348 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 983545008349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545008350 Coenzyme A binding pocket [chemical binding]; other site 983545008351 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 983545008352 Na binding site [ion binding]; other site 983545008353 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 983545008354 EAL domain; Region: EAL; pfam00563 983545008355 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 983545008356 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983545008357 Active Sites [active] 983545008358 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 983545008359 ligand-binding site [chemical binding]; other site 983545008360 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 983545008361 active site 983545008362 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 983545008363 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 983545008364 CysD dimerization site [polypeptide binding]; other site 983545008365 G1 box; other site 983545008366 putative GEF interaction site [polypeptide binding]; other site 983545008367 GTP/Mg2+ binding site [chemical binding]; other site 983545008368 Switch I region; other site 983545008369 G2 box; other site 983545008370 G3 box; other site 983545008371 Switch II region; other site 983545008372 G4 box; other site 983545008373 G5 box; other site 983545008374 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 983545008375 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 983545008376 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 983545008377 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 983545008378 TrkA-C domain; Region: TrkA_C; pfam02080 983545008379 TrkA-C domain; Region: TrkA_C; pfam02080 983545008380 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 983545008381 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 983545008382 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545008383 RNA binding surface [nucleotide binding]; other site 983545008384 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 983545008385 probable active site [active] 983545008386 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983545008387 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983545008388 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 983545008389 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 983545008390 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983545008391 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 983545008392 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 983545008393 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983545008394 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 983545008395 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983545008396 active site 983545008397 Zn binding site [ion binding]; other site 983545008398 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 983545008399 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 983545008400 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983545008401 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 983545008402 methionine sulfoxide reductase B; Provisional; Region: PRK00222 983545008403 SelR domain; Region: SelR; pfam01641 983545008404 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 983545008405 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 983545008406 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 983545008407 active site 983545008408 catalytic site [active] 983545008409 glycogen branching enzyme; Provisional; Region: PRK05402 983545008410 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 983545008411 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 983545008412 active site 983545008413 catalytic site [active] 983545008414 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 983545008415 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 983545008416 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 983545008417 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 983545008418 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 983545008419 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983545008420 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 983545008421 active site 983545008422 phosphate binding residues; other site 983545008423 catalytic residues [active] 983545008424 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 983545008425 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 983545008426 RNase E interface [polypeptide binding]; other site 983545008427 trimer interface [polypeptide binding]; other site 983545008428 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 983545008429 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 983545008430 RNase E interface [polypeptide binding]; other site 983545008431 trimer interface [polypeptide binding]; other site 983545008432 active site 983545008433 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 983545008434 putative nucleic acid binding region [nucleotide binding]; other site 983545008435 G-X-X-G motif; other site 983545008436 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 983545008437 RNA binding site [nucleotide binding]; other site 983545008438 domain interface; other site 983545008439 Pectinacetylesterase; Region: PAE; pfam03283 983545008440 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 983545008441 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983545008442 active site 983545008443 DNA recombination protein RmuC; Provisional; Region: PRK10361 983545008444 RmuC family; Region: RmuC; pfam02646 983545008445 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 983545008446 Fumarase C-terminus; Region: Fumerase_C; pfam05683 983545008447 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 983545008448 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 983545008449 chorismate binding enzyme; Region: Chorismate_bind; cl10555 983545008450 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 983545008451 putative active site [active] 983545008452 putative CoA binding site [chemical binding]; other site 983545008453 nudix motif; other site 983545008454 metal binding site [ion binding]; metal-binding site 983545008455 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 983545008456 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 983545008457 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 983545008458 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 983545008459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545008460 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 983545008461 substrate binding site [chemical binding]; other site 983545008462 dimerization interface [polypeptide binding]; other site 983545008463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545008464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008465 ATP binding site [chemical binding]; other site 983545008466 Mg2+ binding site [ion binding]; other site 983545008467 G-X-G motif; other site 983545008468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545008470 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 983545008471 putative dimerization interface [polypeptide binding]; other site 983545008472 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 983545008473 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 983545008474 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545008475 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545008476 ATP binding site [chemical binding]; other site 983545008477 Mg++ binding site [ion binding]; other site 983545008478 motif III; other site 983545008479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545008480 nucleotide binding region [chemical binding]; other site 983545008481 ATP-binding site [chemical binding]; other site 983545008482 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 983545008483 putative FMN binding site [chemical binding]; other site 983545008484 DoxX; Region: DoxX; pfam07681 983545008485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545008486 active site 983545008487 motif I; other site 983545008488 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 983545008489 motif II; other site 983545008490 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 983545008491 active site 983545008492 dinuclear metal binding site [ion binding]; other site 983545008493 dimerization interface [polypeptide binding]; other site 983545008494 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 983545008495 amidophosphoribosyltransferase; Provisional; Region: PRK09246 983545008496 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 983545008497 active site 983545008498 tetramer interface [polypeptide binding]; other site 983545008499 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545008500 active site 983545008501 Colicin V production protein; Region: Colicin_V; cl00567 983545008502 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 983545008503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 983545008504 Sporulation related domain; Region: SPOR; pfam05036 983545008505 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 983545008506 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545008507 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545008508 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 983545008509 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 983545008510 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 983545008511 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 983545008512 dimerization interface 3.5A [polypeptide binding]; other site 983545008513 active site 983545008514 response regulator GlrR; Provisional; Region: PRK15115 983545008515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008516 active site 983545008517 phosphorylation site [posttranslational modification] 983545008518 intermolecular recognition site; other site 983545008519 dimerization interface [polypeptide binding]; other site 983545008520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545008521 Walker A motif; other site 983545008522 ATP binding site [chemical binding]; other site 983545008523 Walker B motif; other site 983545008524 arginine finger; other site 983545008525 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 983545008526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545008527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545008528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008529 ATP binding site [chemical binding]; other site 983545008530 Mg2+ binding site [ion binding]; other site 983545008531 G-X-G motif; other site 983545008532 EF-hand domain pair; Region: EF_hand_5; pfam13499 983545008533 Ca2+ binding site [ion binding]; other site 983545008534 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 983545008535 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 983545008536 putative metal binding site [ion binding]; other site 983545008537 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 983545008538 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 983545008539 Walker A/P-loop; other site 983545008540 ATP binding site [chemical binding]; other site 983545008541 Q-loop/lid; other site 983545008542 ABC transporter signature motif; other site 983545008543 Walker B; other site 983545008544 D-loop; other site 983545008545 H-loop/switch region; other site 983545008546 TOBE domain; Region: TOBE_2; pfam08402 983545008547 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 983545008548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545008549 dimer interface [polypeptide binding]; other site 983545008550 conserved gate region; other site 983545008551 putative PBP binding loops; other site 983545008552 ABC-ATPase subunit interface; other site 983545008553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545008554 putative PBP binding loops; other site 983545008555 ABC-ATPase subunit interface; other site 983545008556 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 983545008557 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 983545008558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545008559 Coenzyme A binding pocket [chemical binding]; other site 983545008560 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008562 active site 983545008563 phosphorylation site [posttranslational modification] 983545008564 intermolecular recognition site; other site 983545008565 dimerization interface [polypeptide binding]; other site 983545008566 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 983545008567 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 983545008568 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545008569 anti sigma factor interaction site; other site 983545008570 regulatory phosphorylation site [posttranslational modification]; other site 983545008571 translation initiation factor Sui1; Validated; Region: PRK06824 983545008572 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 983545008573 putative rRNA binding site [nucleotide binding]; other site 983545008574 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008576 active site 983545008577 phosphorylation site [posttranslational modification] 983545008578 intermolecular recognition site; other site 983545008579 dimerization interface [polypeptide binding]; other site 983545008580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008581 active site 983545008582 phosphorylation site [posttranslational modification] 983545008583 intermolecular recognition site; other site 983545008584 dimerization interface [polypeptide binding]; other site 983545008585 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 983545008586 Chorismate mutase type II; Region: CM_2; smart00830 983545008587 Prephenate dehydratase; Region: PDT; pfam00800 983545008588 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 983545008589 putative L-Phe binding site [chemical binding]; other site 983545008590 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 983545008591 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 983545008592 Chorismate mutase type II; Region: CM_2; cl00693 983545008593 prephenate dehydrogenase; Validated; Region: PRK08507 983545008594 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 983545008595 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 983545008596 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 983545008597 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545008598 active site 983545008599 Zn binding site [ion binding]; other site 983545008600 maltose O-acetyltransferase; Provisional; Region: PRK10092 983545008601 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 983545008602 active site 983545008603 substrate binding site [chemical binding]; other site 983545008604 trimer interface [polypeptide binding]; other site 983545008605 CoA binding site [chemical binding]; other site 983545008606 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 983545008607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545008608 S-adenosylmethionine binding site [chemical binding]; other site 983545008609 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 983545008610 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 983545008611 DNA binding residues [nucleotide binding] 983545008612 dimer interface [polypeptide binding]; other site 983545008613 [2Fe-2S] cluster binding site [ion binding]; other site 983545008614 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545008615 active site 983545008616 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 983545008617 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 983545008618 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 983545008619 RimM N-terminal domain; Region: RimM; pfam01782 983545008620 PRC-barrel domain; Region: PRC; pfam05239 983545008621 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 983545008622 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 983545008623 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 983545008624 Walker A/P-loop; other site 983545008625 ATP binding site [chemical binding]; other site 983545008626 Q-loop/lid; other site 983545008627 ABC transporter signature motif; other site 983545008628 Walker B; other site 983545008629 D-loop; other site 983545008630 H-loop/switch region; other site 983545008631 Preprotein translocase SecG subunit; Region: SecG; pfam03840 983545008632 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 983545008633 triosephosphate isomerase; Provisional; Region: PRK14567 983545008634 substrate binding site [chemical binding]; other site 983545008635 dimer interface [polypeptide binding]; other site 983545008636 catalytic triad [active] 983545008637 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 983545008638 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 983545008639 active site 983545008640 substrate binding site [chemical binding]; other site 983545008641 metal binding site [ion binding]; metal-binding site 983545008642 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 983545008643 dihydropteroate synthase; Region: DHPS; TIGR01496 983545008644 substrate binding pocket [chemical binding]; other site 983545008645 dimer interface [polypeptide binding]; other site 983545008646 inhibitor binding site; inhibition site 983545008647 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 983545008648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545008649 Walker A motif; other site 983545008650 ATP binding site [chemical binding]; other site 983545008651 Walker B motif; other site 983545008652 arginine finger; other site 983545008653 Peptidase family M41; Region: Peptidase_M41; pfam01434 983545008654 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 983545008655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545008656 S-adenosylmethionine binding site [chemical binding]; other site 983545008657 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 983545008658 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 983545008659 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983545008660 AAA domain; Region: AAA_32; pfam13654 983545008661 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 983545008662 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 983545008663 hydrophobic ligand binding site; other site 983545008664 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 983545008665 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 983545008666 HIGH motif; other site 983545008667 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 983545008668 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545008669 active site 983545008670 KMSKS motif; other site 983545008671 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 983545008672 tRNA binding surface [nucleotide binding]; other site 983545008673 Lipopolysaccharide-assembly; Region: LptE; cl01125 983545008674 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 983545008675 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 983545008676 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 983545008677 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 983545008678 active site 983545008679 (T/H)XGH motif; other site 983545008680 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 983545008681 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 983545008682 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 983545008683 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 983545008684 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 983545008685 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 983545008686 Transglycosylase SLT domain; Region: SLT_2; pfam13406 983545008687 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983545008688 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545008689 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 983545008690 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 983545008691 Sporulation related domain; Region: SPOR; pfam05036 983545008692 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 983545008693 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 983545008694 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 983545008695 hypothetical protein; Provisional; Region: PRK04998 983545008696 lipoate-protein ligase B; Provisional; Region: PRK14342 983545008697 lipoyl synthase; Provisional; Region: PRK05481 983545008698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545008699 FeS/SAM binding site; other site 983545008700 Uncharacterized conserved protein [Function unknown]; Region: COG3542 983545008701 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545008702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008703 metal binding site [ion binding]; metal-binding site 983545008704 active site 983545008705 I-site; other site 983545008706 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 983545008707 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 983545008708 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 983545008709 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 983545008710 active site 983545008711 homodimer interface [polypeptide binding]; other site 983545008712 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 983545008713 DNA-binding site [nucleotide binding]; DNA binding site 983545008714 RNA-binding motif; other site 983545008715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545008716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545008717 putative substrate translocation pore; other site 983545008718 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 983545008719 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 983545008720 Tetramer interface [polypeptide binding]; other site 983545008721 active site 983545008722 FMN-binding site [chemical binding]; other site 983545008723 HemK family putative methylases; Region: hemK_fam; TIGR00536 983545008724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545008725 S-adenosylmethionine binding site [chemical binding]; other site 983545008726 hypothetical protein; Provisional; Region: PRK04946 983545008727 Smr domain; Region: Smr; pfam01713 983545008728 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008730 active site 983545008731 phosphorylation site [posttranslational modification] 983545008732 intermolecular recognition site; other site 983545008733 dimerization interface [polypeptide binding]; other site 983545008734 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545008735 Helix-turn-helix domain; Region: HTH_17; pfam12728 983545008736 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545008737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008738 active site 983545008739 phosphorylation site [posttranslational modification] 983545008740 intermolecular recognition site; other site 983545008741 dimerization interface [polypeptide binding]; other site 983545008742 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 983545008743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545008744 dimerization interface [polypeptide binding]; other site 983545008745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545008746 dimer interface [polypeptide binding]; other site 983545008747 phosphorylation site [posttranslational modification] 983545008748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008749 ATP binding site [chemical binding]; other site 983545008750 Mg2+ binding site [ion binding]; other site 983545008751 G-X-G motif; other site 983545008752 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 983545008753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008754 active site 983545008755 phosphorylation site [posttranslational modification] 983545008756 intermolecular recognition site; other site 983545008757 dimerization interface [polypeptide binding]; other site 983545008758 HD domain; Region: HD_5; pfam13487 983545008759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545008760 dimer interface [polypeptide binding]; other site 983545008761 phosphorylation site [posttranslational modification] 983545008762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008763 ATP binding site [chemical binding]; other site 983545008764 Mg2+ binding site [ion binding]; other site 983545008765 G-X-G motif; other site 983545008766 Heme NO binding; Region: HNOB; pfam07700 983545008767 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 983545008768 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 983545008769 NAD binding site [chemical binding]; other site 983545008770 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 983545008771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545008772 dimerization interface [polypeptide binding]; other site 983545008773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545008774 dimer interface [polypeptide binding]; other site 983545008775 phosphorylation site [posttranslational modification] 983545008776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008777 ATP binding site [chemical binding]; other site 983545008778 Mg2+ binding site [ion binding]; other site 983545008779 G-X-G motif; other site 983545008780 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 983545008781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008782 active site 983545008783 phosphorylation site [posttranslational modification] 983545008784 intermolecular recognition site; other site 983545008785 dimerization interface [polypeptide binding]; other site 983545008786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545008787 DNA binding site [nucleotide binding] 983545008788 YHYH protein; Region: YHYH; pfam14240 983545008789 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 983545008790 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 983545008791 dimer interface [polypeptide binding]; other site 983545008792 ADP-ribose binding site [chemical binding]; other site 983545008793 active site 983545008794 nudix motif; other site 983545008795 metal binding site [ion binding]; metal-binding site 983545008796 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545008797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545008798 DNA binding residues [nucleotide binding] 983545008799 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545008800 FecR protein; Region: FecR; pfam04773 983545008801 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545008802 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545008803 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545008804 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545008805 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 983545008806 active site 983545008807 Zn binding site [ion binding]; other site 983545008808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545008809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545008810 Coenzyme A binding pocket [chemical binding]; other site 983545008811 hypothetical protein; Provisional; Region: PRK10039 983545008812 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545008813 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 983545008814 FtsX-like permease family; Region: FtsX; pfam02687 983545008815 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545008816 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 983545008817 Walker A/P-loop; other site 983545008818 ATP binding site [chemical binding]; other site 983545008819 Q-loop/lid; other site 983545008820 ABC transporter signature motif; other site 983545008821 Walker B; other site 983545008822 D-loop; other site 983545008823 H-loop/switch region; other site 983545008824 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545008825 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545008826 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 983545008827 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983545008828 putative active site [active] 983545008829 Zn binding site [ion binding]; other site 983545008830 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 983545008831 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983545008832 choline dehydrogenase; Validated; Region: PRK02106 983545008833 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545008834 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 983545008835 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545008836 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 983545008837 Predicted permeases [General function prediction only]; Region: COG0679 983545008838 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 983545008839 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545008840 active site 983545008841 Zn binding site [ion binding]; other site 983545008842 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 983545008843 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 983545008844 metal binding site [ion binding]; metal-binding site 983545008845 putative dimer interface [polypeptide binding]; other site 983545008846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545008848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008849 dimerization interface [polypeptide binding]; other site 983545008850 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 983545008851 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 983545008852 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 983545008853 active site 983545008854 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 983545008855 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 983545008856 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 983545008857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 983545008858 Anti-sigma-K factor rskA; Region: RskA; pfam10099 983545008859 RNA polymerase sigma factor; Provisional; Region: PRK12514 983545008860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545008861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545008862 DNA binding residues [nucleotide binding] 983545008863 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 983545008864 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 983545008865 Ligand binding site; other site 983545008866 DXD motif; other site 983545008867 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 983545008868 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 983545008869 fatty acid metabolism regulator; Provisional; Region: PRK04984 983545008870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545008871 DNA-binding site [nucleotide binding]; DNA binding site 983545008872 FadR C-terminal domain; Region: FadR_C; pfam07840 983545008873 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 983545008874 disulfide bond formation protein B; Provisional; Region: PRK01749 983545008875 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 983545008876 Amidinotransferase; Region: Amidinotransf; pfam02274 983545008877 ornithine cyclodeaminase; Validated; Region: PRK07589 983545008878 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 983545008879 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545008880 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 983545008881 AsnC family; Region: AsnC_trans_reg; pfam01037 983545008882 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 983545008883 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 983545008884 hypothetical protein; Provisional; Region: PRK05170 983545008885 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545008886 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 983545008887 Transglycosylase SLT domain; Region: SLT_2; pfam13406 983545008888 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983545008889 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545008890 YcgL domain; Region: YcgL; pfam05166 983545008891 ribonuclease D; Provisional; Region: PRK10829 983545008892 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 983545008893 catalytic site [active] 983545008894 putative active site [active] 983545008895 putative substrate binding site [chemical binding]; other site 983545008896 HRDC domain; Region: HRDC; pfam00570 983545008897 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 983545008898 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983545008899 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 983545008900 acyl-activating enzyme (AAE) consensus motif; other site 983545008901 putative AMP binding site [chemical binding]; other site 983545008902 putative active site [active] 983545008903 putative CoA binding site [chemical binding]; other site 983545008904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 983545008905 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983545008906 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 983545008907 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 983545008908 Glycoprotease family; Region: Peptidase_M22; pfam00814 983545008909 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 983545008910 DEAD/DEAH box helicase; Region: DEAD; pfam00270 983545008911 DEAD_2; Region: DEAD_2; pfam06733 983545008912 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 983545008913 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 983545008914 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545008915 active site 983545008916 catalytic site [active] 983545008917 Flagellar L-ring protein; Region: FlgH; pfam02107 983545008918 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 983545008919 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 983545008920 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 983545008921 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 983545008922 oxidoreductase; Provisional; Region: PRK06128 983545008923 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 983545008924 NAD binding site [chemical binding]; other site 983545008925 metal binding site [ion binding]; metal-binding site 983545008926 active site 983545008927 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 983545008928 active site 983545008929 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 983545008930 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 983545008931 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 983545008932 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 983545008933 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 983545008934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545008935 dimer interface [polypeptide binding]; other site 983545008936 phosphorylation site [posttranslational modification] 983545008937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008938 ATP binding site [chemical binding]; other site 983545008939 Mg2+ binding site [ion binding]; other site 983545008940 G-X-G motif; other site 983545008941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008942 active site 983545008943 phosphorylation site [posttranslational modification] 983545008944 intermolecular recognition site; other site 983545008945 dimerization interface [polypeptide binding]; other site 983545008946 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545008948 active site 983545008949 phosphorylation site [posttranslational modification] 983545008950 intermolecular recognition site; other site 983545008951 dimerization interface [polypeptide binding]; other site 983545008952 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 983545008953 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 983545008954 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 983545008955 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 983545008956 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 983545008957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545008958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008959 dimerization interface [polypeptide binding]; other site 983545008960 Lysine efflux permease [General function prediction only]; Region: COG1279 983545008961 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 983545008962 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545008963 RNA binding surface [nucleotide binding]; other site 983545008964 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 983545008965 probable active site [active] 983545008966 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 983545008967 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 983545008968 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 983545008969 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 983545008970 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 983545008971 active site 983545008972 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 983545008973 anthranilate synthase component I; Provisional; Region: PRK13564 983545008974 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 983545008975 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 983545008976 catalytic triad [active] 983545008977 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 983545008978 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 983545008979 Glutamine amidotransferase class-I; Region: GATase; pfam00117 983545008980 glutamine binding [chemical binding]; other site 983545008981 catalytic triad [active] 983545008982 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 983545008983 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 983545008984 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 983545008985 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 983545008986 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 983545008987 active site 983545008988 ribulose/triose binding site [chemical binding]; other site 983545008989 phosphate binding site [ion binding]; other site 983545008990 substrate (anthranilate) binding pocket [chemical binding]; other site 983545008991 product (indole) binding pocket [chemical binding]; other site 983545008992 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 983545008993 active site 983545008994 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 983545008995 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 983545008996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545008997 catalytic residue [active] 983545008998 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 983545008999 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 983545009000 substrate binding site [chemical binding]; other site 983545009001 active site 983545009002 catalytic residues [active] 983545009003 heterodimer interface [polypeptide binding]; other site 983545009004 YciI-like protein; Reviewed; Region: PRK11370 983545009005 hypothetical protein; Provisional; Region: PRK09256 983545009006 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 983545009007 Predicted membrane protein [Function unknown]; Region: COG3212 983545009008 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545009009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009010 active site 983545009011 phosphorylation site [posttranslational modification] 983545009012 intermolecular recognition site; other site 983545009013 dimerization interface [polypeptide binding]; other site 983545009014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545009015 DNA binding site [nucleotide binding] 983545009016 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 983545009017 dimer interface [polypeptide binding]; other site 983545009018 phosphorylation site [posttranslational modification] 983545009019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009020 ATP binding site [chemical binding]; other site 983545009021 Mg2+ binding site [ion binding]; other site 983545009022 G-X-G motif; other site 983545009023 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 983545009024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545009026 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545009027 putative effector binding pocket; other site 983545009028 dimerization interface [polypeptide binding]; other site 983545009029 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545009030 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 983545009031 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 983545009032 putative molybdopterin cofactor binding site [chemical binding]; other site 983545009033 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 983545009034 putative molybdopterin cofactor binding site; other site 983545009035 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 983545009036 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545009037 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 983545009038 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 983545009039 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 983545009040 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 983545009041 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 983545009042 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983545009043 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009044 N-terminal plug; other site 983545009045 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545009046 ligand-binding site [chemical binding]; other site 983545009047 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 983545009048 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 983545009049 active site 983545009050 DNA binding site [nucleotide binding] 983545009051 Int/Topo IB signature motif; other site 983545009052 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545009053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545009054 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 983545009055 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545009056 putative NAD(P) binding site [chemical binding]; other site 983545009057 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 983545009058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 983545009059 Coenzyme A binding pocket [chemical binding]; other site 983545009060 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545009061 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545009062 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545009063 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545009064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545009065 DNA-binding site [nucleotide binding]; DNA binding site 983545009066 UTRA domain; Region: UTRA; pfam07702 983545009067 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 983545009068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545009069 Walker A/P-loop; other site 983545009070 ATP binding site [chemical binding]; other site 983545009071 Q-loop/lid; other site 983545009072 ABC transporter signature motif; other site 983545009073 Walker B; other site 983545009074 D-loop; other site 983545009075 H-loop/switch region; other site 983545009076 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 983545009077 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983545009078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545009079 Walker A/P-loop; other site 983545009080 ATP binding site [chemical binding]; other site 983545009081 Q-loop/lid; other site 983545009082 ABC transporter signature motif; other site 983545009083 Walker B; other site 983545009084 D-loop; other site 983545009085 H-loop/switch region; other site 983545009086 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 983545009087 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 983545009088 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 983545009089 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 983545009090 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 983545009091 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 983545009092 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545009093 active site 983545009094 metal binding site [ion binding]; metal-binding site 983545009095 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 983545009096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545009097 Coenzyme A binding pocket [chemical binding]; other site 983545009098 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 983545009099 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 983545009100 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 983545009101 heme-binding residues [chemical binding]; other site 983545009102 HEAT repeats; Region: HEAT_2; pfam13646 983545009103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009104 TPR motif; other site 983545009105 TPR repeat; Region: TPR_11; pfam13414 983545009106 binding surface 983545009107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009108 binding surface 983545009109 TPR motif; other site 983545009110 Tetratricopeptide repeat; Region: TPR_16; pfam13432 983545009111 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 983545009112 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 983545009113 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 983545009114 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 983545009115 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 983545009116 maleylacetoacetate isomerase; Region: maiA; TIGR01262 983545009117 C-terminal domain interface [polypeptide binding]; other site 983545009118 GSH binding site (G-site) [chemical binding]; other site 983545009119 putative dimer interface [polypeptide binding]; other site 983545009120 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 983545009121 dimer interface [polypeptide binding]; other site 983545009122 N-terminal domain interface [polypeptide binding]; other site 983545009123 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 983545009124 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 983545009125 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 983545009126 putative ligand binding site [chemical binding]; other site 983545009127 NAD binding site [chemical binding]; other site 983545009128 dimerization interface [polypeptide binding]; other site 983545009129 catalytic site [active] 983545009130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 983545009131 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 983545009132 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 983545009133 Cupin domain; Region: Cupin_2; pfam07883 983545009134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545009135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545009136 Cupin domain; Region: Cupin_2; cl17218 983545009137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545009139 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545009140 putative effector binding pocket; other site 983545009141 dimerization interface [polypeptide binding]; other site 983545009142 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 983545009143 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545009144 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545009145 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 983545009146 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 983545009147 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 983545009148 S-formylglutathione hydrolase; Region: PLN02442 983545009149 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 983545009150 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 983545009151 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 983545009152 substrate binding site [chemical binding]; other site 983545009153 catalytic Zn binding site [ion binding]; other site 983545009154 NAD binding site [chemical binding]; other site 983545009155 structural Zn binding site [ion binding]; other site 983545009156 dimer interface [polypeptide binding]; other site 983545009157 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 983545009158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545009160 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 983545009161 putative effector binding pocket; other site 983545009162 putative dimerization interface [polypeptide binding]; other site 983545009163 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545009164 active site 983545009165 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545009166 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 983545009167 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 983545009168 active site 983545009169 FMN binding site [chemical binding]; other site 983545009170 substrate binding site [chemical binding]; other site 983545009171 3Fe-4S cluster binding site [ion binding]; other site 983545009172 Uncharacterized conserved protein [Function unknown]; Region: COG2966 983545009173 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 983545009174 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 983545009175 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 983545009176 classical (c) SDRs; Region: SDR_c; cd05233 983545009177 NAD(P) binding site [chemical binding]; other site 983545009178 active site 983545009179 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 983545009180 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 983545009181 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 983545009182 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 983545009183 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 983545009184 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 983545009185 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 983545009186 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 983545009187 putative NAD(P) binding site [chemical binding]; other site 983545009188 putative substrate binding site [chemical binding]; other site 983545009189 catalytic Zn binding site [ion binding]; other site 983545009190 structural Zn binding site [ion binding]; other site 983545009191 dimer interface [polypeptide binding]; other site 983545009192 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 983545009193 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545009194 FMN binding site [chemical binding]; other site 983545009195 active site 983545009196 substrate binding site [chemical binding]; other site 983545009197 catalytic residue [active] 983545009198 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545009199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009200 metal binding site [ion binding]; metal-binding site 983545009201 active site 983545009202 I-site; other site 983545009203 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545009204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545009205 putative substrate translocation pore; other site 983545009206 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 983545009207 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 983545009208 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 983545009209 substrate binding site [chemical binding]; other site 983545009210 ligand binding site [chemical binding]; other site 983545009211 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 983545009212 substrate binding site [chemical binding]; other site 983545009213 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 983545009214 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 983545009215 dimer interface [polypeptide binding]; other site 983545009216 active site 983545009217 citrylCoA binding site [chemical binding]; other site 983545009218 oxalacetate/citrate binding site [chemical binding]; other site 983545009219 coenzyme A binding site [chemical binding]; other site 983545009220 catalytic triad [active] 983545009221 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545009222 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 983545009223 tetramer interface [polypeptide binding]; other site 983545009224 active site 983545009225 Mg2+/Mn2+ binding site [ion binding]; other site 983545009226 Transcriptional regulators [Transcription]; Region: GntR; COG1802 983545009227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545009228 DNA-binding site [nucleotide binding]; DNA binding site 983545009229 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 983545009230 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 983545009231 active site 983545009232 NTP binding site [chemical binding]; other site 983545009233 metal binding triad [ion binding]; metal-binding site 983545009234 putative S-transferase; Provisional; Region: PRK11752 983545009235 Predicted transcriptional regulator [Transcription]; Region: COG2944 983545009236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 983545009237 non-specific DNA binding site [nucleotide binding]; other site 983545009238 salt bridge; other site 983545009239 sequence-specific DNA binding site [nucleotide binding]; other site 983545009240 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009241 Sulfatase; Region: Sulfatase; cl17466 983545009242 Sulfatase; Region: Sulfatase; cl17466 983545009243 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545009244 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545009245 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545009246 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545009247 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 983545009248 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545009249 active site 983545009250 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545009251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009252 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 983545009253 NAD(P) binding site [chemical binding]; other site 983545009254 active site 983545009255 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 983545009256 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545009257 Protein of unknown function, DUF599; Region: DUF599; pfam04654 983545009258 multidrug efflux system protein; Provisional; Region: PRK11431 983545009259 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545009260 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 983545009261 dimer interface [polypeptide binding]; other site 983545009262 active site 983545009263 metal binding site [ion binding]; metal-binding site 983545009264 glutathione binding site [chemical binding]; other site 983545009265 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 983545009266 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545009267 active site 983545009268 catalytic site [active] 983545009269 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 983545009270 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545009271 ligand binding site [chemical binding]; other site 983545009272 ribonuclease T; Provisional; Region: PRK05168 983545009273 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 983545009274 active site 983545009275 catalytic site [active] 983545009276 substrate binding site [chemical binding]; other site 983545009277 peroxidase; Provisional; Region: PRK15000 983545009278 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 983545009279 dimer interface [polypeptide binding]; other site 983545009280 decamer (pentamer of dimers) interface [polypeptide binding]; other site 983545009281 catalytic triad [active] 983545009282 peroxidatic and resolving cysteines [active] 983545009283 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 983545009284 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 983545009285 putative GSH binding site [chemical binding]; other site 983545009286 catalytic residues [active] 983545009287 superoxide dismutase; Provisional; Region: PRK10543 983545009288 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 983545009289 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 983545009290 PrkA family serine protein kinase; Provisional; Region: PRK15455 983545009291 AAA ATPase domain; Region: AAA_16; pfam13191 983545009292 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 983545009293 hypothetical protein; Provisional; Region: PRK05325 983545009294 SpoVR family protein; Provisional; Region: PRK11767 983545009295 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 983545009296 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 983545009297 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 983545009298 Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062 983545009299 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 983545009300 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 983545009301 Cupin domain; Region: Cupin_2; cl17218 983545009302 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 983545009303 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 983545009304 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 983545009305 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545009306 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 983545009307 active site 983545009308 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 983545009309 active site 983545009310 catalytic site [active] 983545009311 Domain of unknown function (DUF336); Region: DUF336; pfam03928 983545009312 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545009313 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545009314 active site 983545009315 catalytic tetrad [active] 983545009316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545009318 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545009319 putative effector binding pocket; other site 983545009320 dimerization interface [polypeptide binding]; other site 983545009321 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545009322 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 983545009323 active site 983545009324 FMN binding site [chemical binding]; other site 983545009325 2,4-decadienoyl-CoA binding site; other site 983545009326 catalytic residue [active] 983545009327 4Fe-4S cluster binding site [ion binding]; other site 983545009328 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 983545009329 enoyl-CoA hydratase; Provisional; Region: PRK06142 983545009330 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545009331 substrate binding site [chemical binding]; other site 983545009332 oxyanion hole (OAH) forming residues; other site 983545009333 trimer interface [polypeptide binding]; other site 983545009334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545009335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545009336 WHG domain; Region: WHG; pfam13305 983545009337 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 983545009338 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983545009339 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 983545009340 acyl-activating enzyme (AAE) consensus motif; other site 983545009341 putative AMP binding site [chemical binding]; other site 983545009342 putative active site [active] 983545009343 putative CoA binding site [chemical binding]; other site 983545009344 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 983545009345 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983545009346 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545009347 catalytic residue [active] 983545009348 glutamate--cysteine ligase; Provisional; Region: PRK02107 983545009349 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983545009350 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545009351 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545009352 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983545009353 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545009354 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545009355 Hpt domain; Region: Hpt; pfam01627 983545009356 putative binding surface; other site 983545009357 active site 983545009358 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 983545009359 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983545009360 active site 983545009361 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 983545009362 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 983545009363 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 983545009364 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 983545009365 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 983545009366 dimer interface [polypeptide binding]; other site 983545009367 putative anticodon binding site; other site 983545009368 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 983545009369 motif 1; other site 983545009370 active site 983545009371 motif 2; other site 983545009372 motif 3; other site 983545009373 peptide chain release factor 2; Validated; Region: prfB; PRK00578 983545009374 This domain is found in peptide chain release factors; Region: PCRF; smart00937 983545009375 RF-1 domain; Region: RF-1; pfam00472 983545009376 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 983545009377 arginine-tRNA ligase; Region: PLN02286 983545009378 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 983545009379 active site 983545009380 HIGH motif; other site 983545009381 KMSK motif region; other site 983545009382 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 983545009383 tRNA binding surface [nucleotide binding]; other site 983545009384 anticodon binding site; other site 983545009385 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 983545009386 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 983545009387 G1 box; other site 983545009388 putative GEF interaction site [polypeptide binding]; other site 983545009389 GTP/Mg2+ binding site [chemical binding]; other site 983545009390 Switch I region; other site 983545009391 G2 box; other site 983545009392 G3 box; other site 983545009393 Switch II region; other site 983545009394 G4 box; other site 983545009395 G5 box; other site 983545009396 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 983545009397 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 983545009398 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545009399 putative NAD(P) binding site [chemical binding]; other site 983545009400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545009402 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545009403 putative effector binding pocket; other site 983545009404 dimerization interface [polypeptide binding]; other site 983545009405 Protein of unknown function (DUF465); Region: DUF465; pfam04325 983545009406 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983545009407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009408 NAD(P) binding site [chemical binding]; other site 983545009409 active site 983545009410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545009411 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 983545009412 non-specific DNA binding site [nucleotide binding]; other site 983545009413 salt bridge; other site 983545009414 sequence-specific DNA binding site [nucleotide binding]; other site 983545009415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545009416 non-specific DNA binding site [nucleotide binding]; other site 983545009417 salt bridge; other site 983545009418 sequence-specific DNA binding site [nucleotide binding]; other site 983545009419 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 983545009420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545009421 Coenzyme A binding pocket [chemical binding]; other site 983545009422 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 983545009423 thiamine kinase; Region: ycfN_thiK; TIGR02721 983545009424 active site 983545009425 substrate binding site [chemical binding]; other site 983545009426 ATP binding site [chemical binding]; other site 983545009427 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 983545009428 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545009429 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009430 N-terminal plug; other site 983545009431 ligand-binding site [chemical binding]; other site 983545009432 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 983545009433 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 983545009434 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 983545009435 Helicase; Region: Helicase_RecD; pfam05127 983545009436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545009437 Coenzyme A binding pocket [chemical binding]; other site 983545009438 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 983545009439 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 983545009440 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 983545009441 active site 983545009442 catalytic triad [active] 983545009443 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 983545009444 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545009445 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 983545009446 catalytic residues [active] 983545009447 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 983545009448 PEP-CTERM motif; Region: VPEP; pfam07589 983545009449 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 983545009450 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 983545009451 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545009452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009453 binding surface 983545009454 TPR motif; other site 983545009455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545009456 binding surface 983545009457 TPR motif; other site 983545009458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009459 binding surface 983545009460 TPR motif; other site 983545009461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009462 binding surface 983545009463 TPR motif; other site 983545009464 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 983545009465 Clp amino terminal domain; Region: Clp_N; pfam02861 983545009466 Clp amino terminal domain; Region: Clp_N; pfam02861 983545009467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545009468 Walker A motif; other site 983545009469 ATP binding site [chemical binding]; other site 983545009470 Walker B motif; other site 983545009471 arginine finger; other site 983545009472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545009473 Walker A motif; other site 983545009474 ATP binding site [chemical binding]; other site 983545009475 Walker B motif; other site 983545009476 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 983545009477 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 983545009478 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 983545009479 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 983545009480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545009481 RNA binding surface [nucleotide binding]; other site 983545009482 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983545009483 active site 983545009484 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 983545009485 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 983545009486 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 983545009487 RNA polymerase sigma factor; Provisional; Region: PRK11924 983545009488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545009489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545009490 DNA binding residues [nucleotide binding] 983545009491 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 983545009492 SnoaL-like domain; Region: SnoaL_2; pfam12680 983545009493 short chain dehydrogenase; Provisional; Region: PRK06101 983545009494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009495 NAD(P) binding site [chemical binding]; other site 983545009496 active site 983545009497 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 983545009498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983545009499 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 983545009500 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 983545009501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545009502 S-adenosylmethionine binding site [chemical binding]; other site 983545009503 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 983545009504 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 983545009505 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 983545009506 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545009507 ligand binding site [chemical binding]; other site 983545009508 flagellar motor protein PomA; Reviewed; Region: PRK08990 983545009509 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 983545009510 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 983545009511 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 983545009512 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 983545009513 substrate binding pocket [chemical binding]; other site 983545009514 chain length determination region; other site 983545009515 substrate-Mg2+ binding site; other site 983545009516 catalytic residues [active] 983545009517 aspartate-rich region 1; other site 983545009518 active site lid residues [active] 983545009519 aspartate-rich region 2; other site 983545009520 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 983545009521 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 983545009522 TPP-binding site; other site 983545009523 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 983545009524 PYR/PP interface [polypeptide binding]; other site 983545009525 dimer interface [polypeptide binding]; other site 983545009526 TPP binding site [chemical binding]; other site 983545009527 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983545009528 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 983545009529 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 983545009530 tetramer interfaces [polypeptide binding]; other site 983545009531 binuclear metal-binding site [ion binding]; other site 983545009532 thiamine monophosphate kinase; Provisional; Region: PRK05731 983545009533 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 983545009534 ATP binding site [chemical binding]; other site 983545009535 dimerization interface [polypeptide binding]; other site 983545009536 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 983545009537 putative RNA binding site [nucleotide binding]; other site 983545009538 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 983545009539 homopentamer interface [polypeptide binding]; other site 983545009540 active site 983545009541 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 983545009542 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 983545009543 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 983545009544 dimerization interface [polypeptide binding]; other site 983545009545 active site 983545009546 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 983545009547 Lumazine binding domain; Region: Lum_binding; pfam00677 983545009548 Lumazine binding domain; Region: Lum_binding; pfam00677 983545009549 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 983545009550 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 983545009551 catalytic motif [active] 983545009552 Zn binding site [ion binding]; other site 983545009553 RibD C-terminal domain; Region: RibD_C; cl17279 983545009554 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 983545009555 ATP cone domain; Region: ATP-cone; pfam03477 983545009556 Sporulation related domain; Region: SPOR; pfam05036 983545009557 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 983545009558 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983545009559 Sporulation related domain; Region: SPOR; pfam05036 983545009560 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 983545009561 Predicted integral membrane protein [Function unknown]; Region: COG5616 983545009562 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 983545009563 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 983545009564 dimer interface [polypeptide binding]; other site 983545009565 active site 983545009566 glycine-pyridoxal phosphate binding site [chemical binding]; other site 983545009567 folate binding site [chemical binding]; other site 983545009568 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545009569 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 983545009570 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 983545009571 hypothetical protein; Provisional; Region: PRK07338 983545009572 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 983545009573 metal binding site [ion binding]; metal-binding site 983545009574 dimer interface [polypeptide binding]; other site 983545009575 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 983545009576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545009577 Walker A/P-loop; other site 983545009578 ATP binding site [chemical binding]; other site 983545009579 Q-loop/lid; other site 983545009580 ABC transporter signature motif; other site 983545009581 Walker B; other site 983545009582 D-loop; other site 983545009583 H-loop/switch region; other site 983545009584 ABC transporter; Region: ABC_tran_2; pfam12848 983545009585 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545009586 PAS domain; Region: PAS_9; pfam13426 983545009587 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545009588 GAF domain; Region: GAF; pfam01590 983545009589 PAS fold; Region: PAS_3; pfam08447 983545009590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545009591 heme pocket [chemical binding]; other site 983545009592 putative active site [active] 983545009593 GAF domain; Region: GAF; pfam01590 983545009594 GAF domain; Region: GAF_2; pfam13185 983545009595 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545009596 PAS domain; Region: PAS_9; pfam13426 983545009597 putative active site [active] 983545009598 heme pocket [chemical binding]; other site 983545009599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545009600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545009601 dimer interface [polypeptide binding]; other site 983545009602 phosphorylation site [posttranslational modification] 983545009603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009604 ATP binding site [chemical binding]; other site 983545009605 Mg2+ binding site [ion binding]; other site 983545009606 G-X-G motif; other site 983545009607 Response regulator receiver domain; Region: Response_reg; pfam00072 983545009608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009609 active site 983545009610 phosphorylation site [posttranslational modification] 983545009611 intermolecular recognition site; other site 983545009612 dimerization interface [polypeptide binding]; other site 983545009613 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 983545009614 UbiA prenyltransferase family; Region: UbiA; pfam01040 983545009615 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 983545009616 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 983545009617 Subunit I/III interface [polypeptide binding]; other site 983545009618 Subunit III/IV interface [polypeptide binding]; other site 983545009619 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545009620 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 983545009621 D-pathway; other site 983545009622 Putative ubiquinol binding site [chemical binding]; other site 983545009623 Low-spin heme (heme b) binding site [chemical binding]; other site 983545009624 Putative water exit pathway; other site 983545009625 Binuclear center (heme o3/CuB) [ion binding]; other site 983545009626 K-pathway; other site 983545009627 Putative proton exit pathway; other site 983545009628 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 983545009629 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 983545009630 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 983545009631 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 983545009632 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 983545009633 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983545009634 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545009635 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545009636 active site 983545009637 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 983545009638 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 983545009639 metal binding site [ion binding]; metal-binding site 983545009640 putative dimer interface [polypeptide binding]; other site 983545009641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545009642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545009643 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 983545009644 Uncharacterized conserved protein [Function unknown]; Region: COG3791 983545009645 aconitate hydratase; Validated; Region: PRK09277 983545009646 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 983545009647 substrate binding site [chemical binding]; other site 983545009648 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 983545009649 ligand binding site [chemical binding]; other site 983545009650 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 983545009651 substrate binding site [chemical binding]; other site 983545009652 Entericidin EcnA/B family; Region: Entericidin; pfam08085 983545009653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545009654 dimerization interface [polypeptide binding]; other site 983545009655 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545009656 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009657 metal binding site [ion binding]; metal-binding site 983545009658 active site 983545009659 I-site; other site 983545009660 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545009661 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 983545009662 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 983545009663 DNA repair protein RadA; Provisional; Region: PRK11823 983545009664 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 983545009665 Walker A motif/ATP binding site; other site 983545009666 ATP binding site [chemical binding]; other site 983545009667 Walker B motif; other site 983545009668 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 983545009669 PilZ domain; Region: PilZ; pfam07238 983545009670 PilZ domain; Region: PilZ; pfam07238 983545009671 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 983545009672 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 983545009673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545009674 motif II; other site 983545009675 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 983545009676 homodimer interaction site [polypeptide binding]; other site 983545009677 cofactor binding site; other site 983545009678 prolyl-tRNA synthetase; Provisional; Region: PRK09194 983545009679 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 983545009680 dimer interface [polypeptide binding]; other site 983545009681 motif 1; other site 983545009682 active site 983545009683 motif 2; other site 983545009684 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 983545009685 putative deacylase active site [active] 983545009686 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983545009687 active site 983545009688 motif 3; other site 983545009689 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 983545009690 anticodon binding site; other site 983545009691 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 983545009692 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 983545009693 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 983545009694 nucleophile elbow; other site 983545009695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 983545009696 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 983545009697 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 983545009698 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 983545009699 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 983545009700 oxyanion hole (OAH) forming residues; other site 983545009701 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 983545009702 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 983545009703 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 983545009704 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 983545009705 TrkA-N domain; Region: TrkA_N; pfam02254 983545009706 TrkA-C domain; Region: TrkA_C; pfam02080 983545009707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545009708 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009709 metal binding site [ion binding]; metal-binding site 983545009710 active site 983545009711 I-site; other site 983545009712 Response regulator receiver domain; Region: Response_reg; pfam00072 983545009713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545009714 active site 983545009715 phosphorylation site [posttranslational modification] 983545009716 intermolecular recognition site; other site 983545009717 dimerization interface [polypeptide binding]; other site 983545009718 heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); Region: Ebola_HIV-1-like_HR1-HR2; cl02885 983545009719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545009721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545009722 dimerization interface [polypeptide binding]; other site 983545009723 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 983545009724 active site flap/lid [active] 983545009725 nucleophilic elbow; other site 983545009726 catalytic triad [active] 983545009727 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 983545009728 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 983545009729 Ligand Binding Site [chemical binding]; other site 983545009730 TilS substrate binding domain; Region: TilS; pfam09179 983545009731 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 983545009732 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 983545009733 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 983545009734 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 983545009735 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 983545009736 putative active site [active] 983545009737 putative PHP Thumb interface [polypeptide binding]; other site 983545009738 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 983545009739 generic binding surface I; other site 983545009740 generic binding surface II; other site 983545009741 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 983545009742 RNA/DNA hybrid binding site [nucleotide binding]; other site 983545009743 active site 983545009744 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 983545009745 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 983545009746 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 983545009747 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 983545009748 active site 983545009749 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 983545009750 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 983545009751 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 983545009752 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 983545009753 trimer interface [polypeptide binding]; other site 983545009754 active site 983545009755 UDP-GlcNAc binding site [chemical binding]; other site 983545009756 lipid binding site [chemical binding]; lipid-binding site 983545009757 periplasmic chaperone; Provisional; Region: PRK10780 983545009758 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 983545009759 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 983545009760 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 983545009761 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 983545009762 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 983545009763 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 983545009764 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 983545009765 Surface antigen; Region: Bac_surface_Ag; pfam01103 983545009766 zinc metallopeptidase RseP; Provisional; Region: PRK10779 983545009767 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 983545009768 active site 983545009769 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 983545009770 protein binding site [polypeptide binding]; other site 983545009771 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 983545009772 protein binding site [polypeptide binding]; other site 983545009773 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 983545009774 putative substrate binding region [chemical binding]; other site 983545009775 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 983545009776 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 983545009777 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 983545009778 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 983545009779 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 983545009780 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 983545009781 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 983545009782 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 983545009783 catalytic residue [active] 983545009784 putative FPP diphosphate binding site; other site 983545009785 putative FPP binding hydrophobic cleft; other site 983545009786 dimer interface [polypeptide binding]; other site 983545009787 putative IPP diphosphate binding site; other site 983545009788 ribosome recycling factor; Reviewed; Region: frr; PRK00083 983545009789 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 983545009790 hinge region; other site 983545009791 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 983545009792 putative nucleotide binding site [chemical binding]; other site 983545009793 uridine monophosphate binding site [chemical binding]; other site 983545009794 homohexameric interface [polypeptide binding]; other site 983545009795 elongation factor Ts; Provisional; Region: tsf; PRK09377 983545009796 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 983545009797 Elongation factor TS; Region: EF_TS; pfam00889 983545009798 Elongation factor TS; Region: EF_TS; pfam00889 983545009799 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 983545009800 rRNA interaction site [nucleotide binding]; other site 983545009801 S8 interaction site; other site 983545009802 putative laminin-1 binding site; other site 983545009803 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 983545009804 active site 983545009805 PII uridylyl-transferase; Provisional; Region: PRK05007 983545009806 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545009807 metal binding triad; other site 983545009808 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545009809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545009810 Zn2+ binding site [ion binding]; other site 983545009811 Mg2+ binding site [ion binding]; other site 983545009812 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 983545009813 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 983545009814 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545009815 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983545009816 putative active site [active] 983545009817 putative metal binding site [ion binding]; other site 983545009818 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 983545009819 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983545009820 putative acyl-acceptor binding pocket; other site 983545009821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 983545009822 YebG protein; Region: YebG; pfam07130 983545009823 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 983545009824 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545009825 catalytic loop [active] 983545009826 iron binding site [ion binding]; other site 983545009827 chaperone protein HscA; Provisional; Region: hscA; PRK05183 983545009828 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 983545009829 nucleotide binding site [chemical binding]; other site 983545009830 putative NEF/HSP70 interaction site [polypeptide binding]; other site 983545009831 SBD interface [polypeptide binding]; other site 983545009832 co-chaperone HscB; Provisional; Region: hscB; PRK05014 983545009833 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 983545009834 HSP70 interaction site [polypeptide binding]; other site 983545009835 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 983545009836 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 983545009837 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 983545009838 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 983545009839 trimerization site [polypeptide binding]; other site 983545009840 active site 983545009841 cysteine desulfurase; Provisional; Region: PRK14012 983545009842 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 983545009843 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545009844 catalytic residue [active] 983545009845 Transcriptional regulator; Region: Rrf2; cl17282 983545009846 Rrf2 family protein; Region: rrf2_super; TIGR00738 983545009847 serine O-acetyltransferase; Region: cysE; TIGR01172 983545009848 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 983545009849 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 983545009850 trimer interface [polypeptide binding]; other site 983545009851 active site 983545009852 substrate binding site [chemical binding]; other site 983545009853 CoA binding site [chemical binding]; other site 983545009854 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 983545009855 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 983545009856 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 983545009857 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 983545009858 putative metal binding site [ion binding]; other site 983545009859 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 983545009860 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 983545009861 active site 983545009862 dimerization interface [polypeptide binding]; other site 983545009863 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 983545009864 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 983545009865 Protein export membrane protein; Region: SecD_SecF; pfam02355 983545009866 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 983545009867 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 983545009868 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 983545009869 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 983545009870 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 983545009871 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 983545009872 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 983545009873 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 983545009874 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 983545009875 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 983545009876 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 983545009877 Ion channel; Region: Ion_trans_2; pfam07885 983545009878 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 983545009879 Predicted membrane protein [Function unknown]; Region: COG3766 983545009880 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 983545009881 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 983545009882 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 983545009883 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 983545009884 Rhomboid family; Region: Rhomboid; pfam01694 983545009885 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 983545009886 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545009887 active site 983545009888 dimer interface [polypeptide binding]; other site 983545009889 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545009890 tetramer interface [polypeptide binding]; other site 983545009891 active site 983545009892 Mg2+/Mn2+ binding site [ion binding]; other site 983545009893 isocitrate lyase; Region: PLN02892 983545009894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545009896 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545009897 substrate binding pocket [chemical binding]; other site 983545009898 dimerization interface [polypeptide binding]; other site 983545009899 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 983545009900 active site 983545009901 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 983545009902 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 983545009903 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 983545009904 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545009905 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 983545009906 putative NAD(P) binding site [chemical binding]; other site 983545009907 active site 983545009908 putative substrate binding site [chemical binding]; other site 983545009909 Uncharacterized conserved protein [Function unknown]; Region: COG1434 983545009910 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 983545009911 putative active site [active] 983545009912 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 983545009913 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 983545009914 active site 983545009915 nucleophile elbow; other site 983545009916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 983545009917 FAD binding domain; Region: FAD_binding_4; pfam01565 983545009918 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545009919 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545009920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009921 binding surface 983545009922 TPR motif; other site 983545009923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009924 TPR motif; other site 983545009925 binding surface 983545009926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009927 binding surface 983545009928 TPR motif; other site 983545009929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545009930 binding surface 983545009931 TPR motif; other site 983545009932 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 983545009933 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545009934 active site 983545009935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009936 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545009937 putative ADP-binding pocket [chemical binding]; other site 983545009938 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 983545009939 putative active site [active] 983545009940 putative catalytic site [active] 983545009941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 983545009942 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545009943 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545009944 active site 983545009945 dimer interface [polypeptide binding]; other site 983545009946 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983545009947 Ligand Binding Site [chemical binding]; other site 983545009948 Molecular Tunnel; other site 983545009949 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 983545009950 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 983545009951 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 983545009952 putative ADP-binding pocket [chemical binding]; other site 983545009953 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 983545009954 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 983545009955 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545009956 active site 983545009957 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 983545009958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545009959 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983545009960 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 983545009961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009962 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545009963 serine O-acetyltransferase; Region: cysE; TIGR01172 983545009964 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 983545009965 trimer interface [polypeptide binding]; other site 983545009966 active site 983545009967 substrate binding site [chemical binding]; other site 983545009968 CoA binding site [chemical binding]; other site 983545009969 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545009970 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 983545009971 O-Antigen ligase; Region: Wzy_C; pfam04932 983545009972 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 983545009973 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 983545009974 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 983545009975 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 983545009976 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 983545009977 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 983545009978 putative active site [active] 983545009979 putative catalytic site [active] 983545009980 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 983545009981 Bacterial sugar transferase; Region: Bac_transf; pfam02397 983545009982 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545009983 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545009984 SLBB domain; Region: SLBB; pfam10531 983545009985 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 983545009986 Chain length determinant protein; Region: Wzz; pfam02706 983545009987 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 983545009988 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 983545009989 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 983545009990 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 983545009991 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 983545009992 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 983545009993 TrkA-N domain; Region: TrkA_N; pfam02254 983545009994 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 983545009995 active site 983545009996 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 983545009997 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 983545009998 putative active site [active] 983545009999 Zn binding site [ion binding]; other site 983545010000 hypothetical protein; Provisional; Region: PRK11239 983545010001 Protein of unknown function, DUF480; Region: DUF480; pfam04337 983545010002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545010003 Coenzyme A binding pocket [chemical binding]; other site 983545010004 Helix-turn-helix domain; Region: HTH_18; pfam12833 983545010005 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545010006 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 983545010007 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 983545010008 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545010009 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 983545010010 PAS fold; Region: PAS_4; pfam08448 983545010011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545010012 putative active site [active] 983545010013 heme pocket [chemical binding]; other site 983545010014 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 983545010015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010016 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 983545010017 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 983545010018 ligand binding site [chemical binding]; other site 983545010019 NAD binding site [chemical binding]; other site 983545010020 tetramer interface [polypeptide binding]; other site 983545010021 catalytic site [active] 983545010022 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 983545010023 L-serine binding site [chemical binding]; other site 983545010024 ACT domain interface; other site 983545010025 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983545010026 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983545010027 catalytic residues [active] 983545010028 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 983545010029 hypothetical protein; Validated; Region: PRK00228 983545010030 glutathione synthetase; Provisional; Region: PRK05246 983545010031 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 983545010032 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 983545010033 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983545010034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010035 active site 983545010036 phosphorylation site [posttranslational modification] 983545010037 intermolecular recognition site; other site 983545010038 dimerization interface [polypeptide binding]; other site 983545010039 LytTr DNA-binding domain; Region: LytTR; smart00850 983545010040 Histidine kinase; Region: His_kinase; pfam06580 983545010041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010042 ATP binding site [chemical binding]; other site 983545010043 Mg2+ binding site [ion binding]; other site 983545010044 G-X-G motif; other site 983545010045 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983545010046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010047 active site 983545010048 phosphorylation site [posttranslational modification] 983545010049 intermolecular recognition site; other site 983545010050 dimerization interface [polypeptide binding]; other site 983545010051 LytTr DNA-binding domain; Region: LytTR; smart00850 983545010052 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 983545010053 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010054 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010055 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545010056 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 983545010057 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545010058 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545010059 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 983545010060 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545010061 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 983545010062 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545010063 Domain of unknown function (DUF305); Region: DUF305; cl17794 983545010064 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 983545010065 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 983545010066 putative metal dependent hydrolase; Provisional; Region: PRK11598 983545010067 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545010068 Sulfatase; Region: Sulfatase; pfam00884 983545010069 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 983545010070 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 983545010071 Uncharacterized conserved protein [Function unknown]; Region: COG0398 983545010072 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 983545010073 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 983545010074 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 983545010075 Ligand binding site; other site 983545010076 Putative Catalytic site; other site 983545010077 DXD motif; other site 983545010078 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545010079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010080 active site 983545010081 phosphorylation site [posttranslational modification] 983545010082 intermolecular recognition site; other site 983545010083 dimerization interface [polypeptide binding]; other site 983545010084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545010085 DNA binding site [nucleotide binding] 983545010086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545010087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010088 dimer interface [polypeptide binding]; other site 983545010089 phosphorylation site [posttranslational modification] 983545010090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010091 ATP binding site [chemical binding]; other site 983545010092 Mg2+ binding site [ion binding]; other site 983545010093 G-X-G motif; other site 983545010094 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545010095 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 983545010096 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 983545010097 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545010098 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010099 N-terminal plug; other site 983545010100 ligand-binding site [chemical binding]; other site 983545010101 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 983545010102 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 983545010103 Walker A/P-loop; other site 983545010104 ATP binding site [chemical binding]; other site 983545010105 Q-loop/lid; other site 983545010106 ABC transporter signature motif; other site 983545010107 Walker B; other site 983545010108 D-loop; other site 983545010109 H-loop/switch region; other site 983545010110 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 983545010111 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 983545010112 ABC-ATPase subunit interface; other site 983545010113 dimer interface [polypeptide binding]; other site 983545010114 putative PBP binding regions; other site 983545010115 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 983545010116 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 983545010117 active site pocket [active] 983545010118 putative dimer interface [polypeptide binding]; other site 983545010119 putative cataytic base [active] 983545010120 cobalamin synthase; Reviewed; Region: cobS; PRK00235 983545010121 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 983545010122 homotrimer interface [polypeptide binding]; other site 983545010123 Walker A motif; other site 983545010124 GTP binding site [chemical binding]; other site 983545010125 Walker B motif; other site 983545010126 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545010127 catalytic core [active] 983545010128 cobyric acid synthase; Provisional; Region: PRK00784 983545010129 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 983545010130 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 983545010131 catalytic triad [active] 983545010132 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 983545010133 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 983545010134 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 983545010135 homodimer interface [polypeptide binding]; other site 983545010136 Walker A motif; other site 983545010137 ATP binding site [chemical binding]; other site 983545010138 hydroxycobalamin binding site [chemical binding]; other site 983545010139 Walker B motif; other site 983545010140 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 983545010141 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 983545010142 cobalamin binding residues [chemical binding]; other site 983545010143 putative BtuC binding residues; other site 983545010144 dimer interface [polypeptide binding]; other site 983545010145 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545010146 catalytic core [active] 983545010147 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 983545010148 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 983545010149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545010150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545010151 homodimer interface [polypeptide binding]; other site 983545010152 catalytic residue [active] 983545010153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545010154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545010155 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545010156 putative effector binding pocket; other site 983545010157 dimerization interface [polypeptide binding]; other site 983545010158 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545010159 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 983545010160 putative C-terminal domain interface [polypeptide binding]; other site 983545010161 putative GSH binding site (G-site) [chemical binding]; other site 983545010162 putative dimer interface [polypeptide binding]; other site 983545010163 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 983545010164 putative N-terminal domain interface [polypeptide binding]; other site 983545010165 putative dimer interface [polypeptide binding]; other site 983545010166 putative substrate binding pocket (H-site) [chemical binding]; other site 983545010167 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545010168 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545010169 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 983545010170 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 983545010171 FAD binding pocket [chemical binding]; other site 983545010172 FAD binding motif [chemical binding]; other site 983545010173 phosphate binding motif [ion binding]; other site 983545010174 beta-alpha-beta structure motif; other site 983545010175 NAD binding pocket [chemical binding]; other site 983545010176 Heme binding pocket [chemical binding]; other site 983545010177 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545010178 catalytic loop [active] 983545010179 iron binding site [ion binding]; other site 983545010180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 983545010181 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983545010182 Interdomain contacts; other site 983545010183 Cytokine receptor motif; other site 983545010184 dimerization interface [polypeptide binding]; other site 983545010185 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 983545010186 putative active cleft [active] 983545010187 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545010188 active site 983545010189 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 983545010190 Na binding site [ion binding]; other site 983545010191 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545010192 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545010193 DNA binding site [nucleotide binding] 983545010194 domain linker motif; other site 983545010195 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545010196 dimerization interface [polypeptide binding]; other site 983545010197 ligand binding site [chemical binding]; other site 983545010198 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 983545010199 dimerization interface [polypeptide binding]; other site 983545010200 putative active cleft [active] 983545010201 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010202 Sulfatase; Region: Sulfatase; pfam00884 983545010203 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 983545010204 nudix motif; other site 983545010205 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010206 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010207 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010208 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 983545010209 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 983545010210 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983545010211 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010212 N-terminal plug; other site 983545010213 ligand-binding site [chemical binding]; other site 983545010214 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 983545010215 Carbon starvation protein CstA; Region: CstA; pfam02554 983545010216 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 983545010217 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 983545010218 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983545010219 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983545010220 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545010221 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 983545010222 tetramer interface [polypeptide binding]; other site 983545010223 heme binding pocket [chemical binding]; other site 983545010224 Uncharacterized conserved protein [Function unknown]; Region: COG3379 983545010225 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 983545010226 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 983545010227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 983545010228 FeS/SAM binding site; other site 983545010229 HemN C-terminal domain; Region: HemN_C; pfam06969 983545010230 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 983545010231 active site 983545010232 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 983545010233 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 983545010234 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 983545010235 Acyltransferase family; Region: Acyl_transf_3; pfam01757 983545010236 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 983545010237 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983545010238 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545010239 active site 983545010240 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 983545010241 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545010242 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545010243 putative ADP-binding pocket [chemical binding]; other site 983545010244 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545010245 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545010246 putative ADP-binding pocket [chemical binding]; other site 983545010247 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 983545010248 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 983545010249 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545010250 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 983545010251 putative NAD(P) binding site [chemical binding]; other site 983545010252 active site 983545010253 putative substrate binding site [chemical binding]; other site 983545010254 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545010255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545010256 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545010257 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 983545010258 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983545010259 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 983545010260 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 983545010261 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 983545010262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545010263 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545010264 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010265 metal binding site [ion binding]; metal-binding site 983545010266 active site 983545010267 I-site; other site 983545010268 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545010269 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 983545010270 O-Antigen ligase; Region: Wzy_C; pfam04932 983545010271 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 983545010272 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 983545010273 Chain length determinant protein; Region: Wzz; pfam02706 983545010274 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 983545010275 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 983545010276 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 983545010277 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545010278 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545010279 SLBB domain; Region: SLBB; pfam10531 983545010280 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 983545010281 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 983545010282 Bacterial sugar transferase; Region: Bac_transf; pfam02397 983545010283 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 983545010284 C2 domain; Region: C2; cl14603 983545010285 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 983545010286 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 983545010287 catalytic residue [active] 983545010288 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 983545010289 catalytic residues [active] 983545010290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545010291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545010292 peroxiredoxin; Region: AhpC; TIGR03137 983545010293 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 983545010294 dimer interface [polypeptide binding]; other site 983545010295 decamer (pentamer of dimers) interface [polypeptide binding]; other site 983545010296 catalytic triad [active] 983545010297 peroxidatic and resolving cysteines [active] 983545010298 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545010300 binding surface 983545010301 TPR motif; other site 983545010302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545010304 binding surface 983545010305 TPR motif; other site 983545010306 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 983545010307 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 983545010308 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 983545010309 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 983545010310 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 983545010311 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 983545010312 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 983545010313 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010314 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010315 N-terminal plug; other site 983545010316 ligand-binding site [chemical binding]; other site 983545010317 Cytochrome c; Region: Cytochrom_C; pfam00034 983545010318 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 983545010319 Lipase (class 2); Region: Lipase_2; pfam01674 983545010320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545010321 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010322 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 983545010323 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010324 Peptidase M35 family; Region: M35_like; cl03449 983545010325 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 983545010326 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 983545010327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010328 dimer interface [polypeptide binding]; other site 983545010329 phosphorylation site [posttranslational modification] 983545010330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010331 ATP binding site [chemical binding]; other site 983545010332 Mg2+ binding site [ion binding]; other site 983545010333 G-X-G motif; other site 983545010334 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 983545010335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010336 active site 983545010337 phosphorylation site [posttranslational modification] 983545010338 intermolecular recognition site; other site 983545010339 dimerization interface [polypeptide binding]; other site 983545010340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545010341 DNA binding site [nucleotide binding] 983545010342 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 983545010343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545010344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010345 ATP binding site [chemical binding]; other site 983545010346 Mg2+ binding site [ion binding]; other site 983545010347 G-X-G motif; other site 983545010348 Putative exonuclease, RdgC; Region: RdgC; pfam04381 983545010349 HDOD domain; Region: HDOD; pfam08668 983545010350 Nudix hydrolase homolog; Region: PLN02791 983545010351 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545010352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010353 metal binding site [ion binding]; metal-binding site 983545010354 active site 983545010355 I-site; other site 983545010356 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545010357 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 983545010358 nucleotide binding site/active site [active] 983545010359 HIT family signature motif; other site 983545010360 catalytic residue [active] 983545010361 Bacitracin resistance protein BacA; Region: BacA; pfam02673 983545010362 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 983545010363 catalytic center binding site [active] 983545010364 ATP binding site [chemical binding]; other site 983545010365 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 983545010366 homooctamer interface [polypeptide binding]; other site 983545010367 active site 983545010368 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 983545010369 UGMP family protein; Validated; Region: PRK09604 983545010370 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 983545010371 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 983545010372 Yqey-like protein; Region: YqeY; pfam09424 983545010373 DNA primase; Validated; Region: dnaG; PRK05667 983545010374 CHC2 zinc finger; Region: zf-CHC2; pfam01807 983545010375 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 983545010376 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 983545010377 active site 983545010378 metal binding site [ion binding]; metal-binding site 983545010379 interdomain interaction site; other site 983545010380 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 983545010381 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 983545010382 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 983545010383 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 983545010384 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545010385 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 983545010386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545010387 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983545010388 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545010389 DNA binding residues [nucleotide binding] 983545010390 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545010391 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545010392 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545010393 Endonuclease I; Region: Endonuclease_1; pfam04231 983545010394 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 983545010395 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 983545010396 generic binding surface I; other site 983545010397 generic binding surface II; other site 983545010398 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545010399 putative catalytic site [active] 983545010400 putative metal binding site [ion binding]; other site 983545010401 putative phosphate binding site [ion binding]; other site 983545010402 RNase E inhibitor protein; Provisional; Region: PRK11191 983545010403 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 983545010404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 983545010405 putative acyl-acceptor binding pocket; other site 983545010406 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545010407 putative binding surface; other site 983545010408 active site 983545010409 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545010410 Zn2+ binding site [ion binding]; other site 983545010411 Mg2+ binding site [ion binding]; other site 983545010412 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 983545010413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010414 active site 983545010415 phosphorylation site [posttranslational modification] 983545010416 intermolecular recognition site; other site 983545010417 dimerization interface [polypeptide binding]; other site 983545010418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545010419 Walker A motif; other site 983545010420 ATP binding site [chemical binding]; other site 983545010421 Walker B motif; other site 983545010422 arginine finger; other site 983545010423 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 983545010424 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 983545010425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545010426 putative active site [active] 983545010427 heme pocket [chemical binding]; other site 983545010428 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010429 dimer interface [polypeptide binding]; other site 983545010430 phosphorylation site [posttranslational modification] 983545010431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010432 ATP binding site [chemical binding]; other site 983545010433 Mg2+ binding site [ion binding]; other site 983545010434 G-X-G motif; other site 983545010435 glutamine synthetase; Provisional; Region: glnA; PRK09469 983545010436 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 983545010437 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 983545010438 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 983545010439 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 983545010440 G1 box; other site 983545010441 putative GEF interaction site [polypeptide binding]; other site 983545010442 GTP/Mg2+ binding site [chemical binding]; other site 983545010443 Switch I region; other site 983545010444 G2 box; other site 983545010445 G3 box; other site 983545010446 Switch II region; other site 983545010447 G4 box; other site 983545010448 G5 box; other site 983545010449 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 983545010450 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 983545010451 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 983545010452 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 983545010453 active site 983545010454 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 983545010455 active sites [active] 983545010456 tetramer interface [polypeptide binding]; other site 983545010457 urocanate hydratase; Provisional; Region: PRK05414 983545010458 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 983545010459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545010460 DNA-binding site [nucleotide binding]; DNA binding site 983545010461 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 983545010462 imidazolonepropionase; Validated; Region: PRK09356 983545010463 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 983545010464 active site 983545010465 formimidoylglutamase; Provisional; Region: PRK13775 983545010466 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 983545010467 putative active site [active] 983545010468 putative metal binding site [ion binding]; other site 983545010469 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 983545010470 dimer interface [polypeptide binding]; other site 983545010471 FMN binding site [chemical binding]; other site 983545010472 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 983545010473 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 983545010474 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 983545010475 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 983545010476 alphaNTD homodimer interface [polypeptide binding]; other site 983545010477 alphaNTD - beta interaction site [polypeptide binding]; other site 983545010478 alphaNTD - beta' interaction site [polypeptide binding]; other site 983545010479 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 983545010480 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 983545010481 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 983545010482 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545010483 RNA binding surface [nucleotide binding]; other site 983545010484 30S ribosomal protein S11; Validated; Region: PRK05309 983545010485 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 983545010486 30S ribosomal protein S13; Region: bact_S13; TIGR03631 983545010487 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 983545010488 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 983545010489 SecY translocase; Region: SecY; pfam00344 983545010490 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 983545010491 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 983545010492 23S rRNA binding site [nucleotide binding]; other site 983545010493 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 983545010494 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 983545010495 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 983545010496 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 983545010497 5S rRNA interface [nucleotide binding]; other site 983545010498 23S rRNA interface [nucleotide binding]; other site 983545010499 L5 interface [polypeptide binding]; other site 983545010500 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 983545010501 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 983545010502 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 983545010503 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 983545010504 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 983545010505 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 983545010506 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 983545010507 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 983545010508 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 983545010509 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 983545010510 RNA binding site [nucleotide binding]; other site 983545010511 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 983545010512 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 983545010513 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 983545010514 acyl-activating enzyme (AAE) consensus motif; other site 983545010515 putative AMP binding site [chemical binding]; other site 983545010516 putative active site [active] 983545010517 putative CoA binding site [chemical binding]; other site 983545010518 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 983545010519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545010520 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 983545010521 dimerization interface [polypeptide binding]; other site 983545010522 substrate binding pocket [chemical binding]; other site 983545010523 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 983545010524 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 983545010525 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 983545010526 ribonuclease R; Region: RNase_R; TIGR02063 983545010527 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 983545010528 RNB domain; Region: RNB; pfam00773 983545010529 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 983545010530 RNA binding site [nucleotide binding]; other site 983545010531 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 983545010532 Sel1-like repeats; Region: SEL1; smart00671 983545010533 Phosphate-starvation-inducible E; Region: PsiE; cl01264 983545010534 FMN reductase; Validated; Region: fre; PRK08051 983545010535 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 983545010536 FAD binding pocket [chemical binding]; other site 983545010537 FAD binding motif [chemical binding]; other site 983545010538 phosphate binding motif [ion binding]; other site 983545010539 beta-alpha-beta structure motif; other site 983545010540 NAD binding pocket [chemical binding]; other site 983545010541 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 983545010542 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 983545010543 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983545010544 two-component sensor protein; Provisional; Region: cpxA; PRK09470 983545010545 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545010546 dimerization interface [polypeptide binding]; other site 983545010547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010548 dimer interface [polypeptide binding]; other site 983545010549 phosphorylation site [posttranslational modification] 983545010550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010551 ATP binding site [chemical binding]; other site 983545010552 Mg2+ binding site [ion binding]; other site 983545010553 G-X-G motif; other site 983545010554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545010555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010556 active site 983545010557 phosphorylation site [posttranslational modification] 983545010558 intermolecular recognition site; other site 983545010559 dimerization interface [polypeptide binding]; other site 983545010560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545010561 DNA binding site [nucleotide binding] 983545010562 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 983545010563 dimer interface [polypeptide binding]; other site 983545010564 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 983545010565 active site 983545010566 dimer interfaces [polypeptide binding]; other site 983545010567 catalytic residues [active] 983545010568 Galactose oxidase, central domain; Region: Kelch_3; cl02701 983545010569 acetylornithine deacetylase; Provisional; Region: PRK05111 983545010570 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 983545010571 metal binding site [ion binding]; metal-binding site 983545010572 putative dimer interface [polypeptide binding]; other site 983545010573 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 983545010574 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 983545010575 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 983545010576 nucleotide binding site [chemical binding]; other site 983545010577 N-acetyl-L-glutamate binding site [chemical binding]; other site 983545010578 ornithine carbamoyltransferase; Provisional; Region: PRK14805 983545010579 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 983545010580 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 983545010581 argininosuccinate synthase; Provisional; Region: PRK13820 983545010582 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 983545010583 ANP binding site [chemical binding]; other site 983545010584 Substrate Binding Site II [chemical binding]; other site 983545010585 Substrate Binding Site I [chemical binding]; other site 983545010586 argininosuccinate lyase; Provisional; Region: PRK04833 983545010587 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 983545010588 active sites [active] 983545010589 tetramer interface [polypeptide binding]; other site 983545010590 N-acetylglutamate synthase; Validated; Region: PRK05279 983545010591 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 983545010592 putative feedback inhibition sensing region; other site 983545010593 putative nucleotide binding site [chemical binding]; other site 983545010594 putative substrate binding site [chemical binding]; other site 983545010595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545010596 Coenzyme A binding pocket [chemical binding]; other site 983545010597 HopJ type III effector protein; Region: HopJ; pfam08888 983545010598 Flagellin N-methylase; Region: FliB; cl00497 983545010599 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 983545010600 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545010601 active site 983545010602 intersubunit interface [polypeptide binding]; other site 983545010603 catalytic residue [active] 983545010604 glucokinase; Provisional; Region: glk; PRK00292 983545010605 glucokinase, proteobacterial type; Region: glk; TIGR00749 983545010606 phosphogluconate dehydratase; Validated; Region: PRK09054 983545010607 6-phosphogluconate dehydratase; Region: edd; TIGR01196 983545010608 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 983545010609 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 983545010610 putative active site [active] 983545010611 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 983545010612 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 983545010613 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 983545010614 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 983545010615 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 983545010616 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 983545010617 putative active site [active] 983545010618 pyruvate kinase; Provisional; Region: PRK05826 983545010619 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 983545010620 domain interfaces; other site 983545010621 active site 983545010622 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545010623 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010624 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010625 N-terminal plug; other site 983545010626 ligand-binding site [chemical binding]; other site 983545010627 Uncharacterized conserved protein [Function unknown]; Region: COG3268 983545010628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010629 NAD(P) binding site [chemical binding]; other site 983545010630 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 983545010631 EF-hand domain pair; Region: EF_hand_5; pfam13499 983545010632 Ca2+ binding site [ion binding]; other site 983545010633 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 983545010634 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 983545010635 active site residue [active] 983545010636 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545010637 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 983545010638 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545010639 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 983545010640 active site 983545010641 ATP binding site [chemical binding]; other site 983545010642 substrate binding site [chemical binding]; other site 983545010643 activation loop (A-loop); other site 983545010644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010645 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545010647 binding surface 983545010648 TPR motif; other site 983545010649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545010650 binding surface 983545010651 TPR motif; other site 983545010652 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 983545010654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 983545010655 binding surface 983545010656 TPR motif; other site 983545010657 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545010658 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545010659 MASE1; Region: MASE1; cl17823 983545010660 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 983545010661 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 983545010662 putative active site [active] 983545010663 putative dimer interface [polypeptide binding]; other site 983545010664 NIPSNAP; Region: NIPSNAP; pfam07978 983545010665 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 983545010666 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 983545010667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010668 NAD(P) binding site [chemical binding]; other site 983545010669 active site 983545010670 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 983545010671 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 983545010672 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 983545010673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545010674 substrate binding site [chemical binding]; other site 983545010675 oxyanion hole (OAH) forming residues; other site 983545010676 trimer interface [polypeptide binding]; other site 983545010677 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 983545010678 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545010679 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 983545010680 substrate binding pocket [chemical binding]; other site 983545010681 FAD binding site [chemical binding]; other site 983545010682 catalytic base [active] 983545010683 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 983545010684 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 983545010685 tetrameric interface [polypeptide binding]; other site 983545010686 NAD binding site [chemical binding]; other site 983545010687 catalytic residues [active] 983545010688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010689 active site 983545010690 phosphorylation site [posttranslational modification] 983545010691 intermolecular recognition site; other site 983545010692 dimerization interface [polypeptide binding]; other site 983545010693 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 983545010694 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 983545010695 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 983545010696 active site 983545010697 dimer interface [polypeptide binding]; other site 983545010698 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010699 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010700 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010701 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010702 N-terminal plug; other site 983545010703 ligand-binding site [chemical binding]; other site 983545010704 SnoaL-like domain; Region: SnoaL_3; pfam13474 983545010705 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 983545010706 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 983545010707 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 983545010708 Switch I; other site 983545010709 Switch II; other site 983545010710 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 983545010711 septum formation inhibitor; Reviewed; Region: minC; PRK00339 983545010712 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 983545010713 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 983545010714 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 983545010715 FMN binding site [chemical binding]; other site 983545010716 substrate binding site [chemical binding]; other site 983545010717 putative catalytic residue [active] 983545010718 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 983545010719 maleylacetoacetate isomerase; Region: maiA; TIGR01262 983545010720 C-terminal domain interface [polypeptide binding]; other site 983545010721 GSH binding site (G-site) [chemical binding]; other site 983545010722 putative dimer interface [polypeptide binding]; other site 983545010723 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 983545010724 dimer interface [polypeptide binding]; other site 983545010725 N-terminal domain interface [polypeptide binding]; other site 983545010726 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 983545010727 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 983545010728 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 983545010729 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 983545010730 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 983545010731 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545010732 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 983545010733 Na binding site [ion binding]; other site 983545010734 Protein of unknown function, DUF485; Region: DUF485; pfam04341 983545010735 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010736 Sulfatase; Region: Sulfatase; pfam00884 983545010737 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010738 Sulfatase; Region: Sulfatase; pfam00884 983545010739 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010740 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545010742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545010743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 983545010744 dimerization interface [polypeptide binding]; other site 983545010745 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 983545010746 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 983545010747 substrate binding site [chemical binding]; other site 983545010748 THF binding site; other site 983545010749 zinc-binding site [ion binding]; other site 983545010750 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 983545010751 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 983545010752 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983545010753 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 983545010754 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545010755 active site 983545010756 intersubunit interface [polypeptide binding]; other site 983545010757 catalytic residue [active] 983545010758 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 983545010759 active site 983545010760 catalytic residues [active] 983545010761 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 983545010762 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 983545010763 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 983545010764 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545010765 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545010766 substrate binding site [chemical binding]; other site 983545010767 ATP binding site [chemical binding]; other site 983545010768 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 983545010769 putative transporter; Provisional; Region: PRK10484 983545010770 Na binding site [ion binding]; other site 983545010771 substrate binding site [chemical binding]; other site 983545010772 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 983545010773 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 983545010774 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 983545010775 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 983545010776 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545010777 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545010778 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 983545010779 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 983545010780 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 983545010781 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010782 Sulfatase; Region: Sulfatase; cl17466 983545010783 Sulfatase; Region: Sulfatase; cl17466 983545010784 Cupin domain; Region: Cupin_2; cl17218 983545010785 Helix-turn-helix domain; Region: HTH_18; pfam12833 983545010786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010787 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010788 Sulfatase; Region: Sulfatase; pfam00884 983545010789 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 983545010790 Probable beta-xylosidase; Provisional; Region: PLN03080 983545010791 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 983545010792 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 983545010793 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545010794 calcium binding site [ion binding]; other site 983545010795 active site 983545010796 catalytic residues [active] 983545010797 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 983545010798 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 983545010799 Domain of unknown function (DUF718); Region: DUF718; cl01281 983545010800 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 983545010801 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545010802 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545010803 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 983545010804 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 983545010805 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010806 Sulfatase; Region: Sulfatase; pfam00884 983545010807 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010808 Sulfatase; Region: Sulfatase; pfam00884 983545010809 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010810 Sulfatase; Region: Sulfatase; cl17466 983545010811 HEAT repeats; Region: HEAT_2; pfam13646 983545010812 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 983545010813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545010814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010816 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 983545010817 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 983545010818 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 983545010819 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 983545010820 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 983545010821 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 983545010822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 983545010823 Sulfatase; Region: Sulfatase; cl17466 983545010824 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 983545010825 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010826 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 983545010827 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010828 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545010829 N-terminal plug; other site 983545010830 ligand-binding site [chemical binding]; other site 983545010831 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545010832 active site 983545010833 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 983545010834 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 983545010835 substrate binding site [chemical binding]; other site 983545010836 active site 983545010837 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 983545010838 metal binding site [ion binding]; metal-binding site 983545010839 ligand binding site [chemical binding]; other site 983545010840 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010841 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010842 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010843 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010844 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545010845 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 983545010846 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 983545010847 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545010848 DNA polymerase I; Provisional; Region: PRK05755 983545010849 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545010850 calcium binding site [ion binding]; other site 983545010851 active site 983545010852 catalytic residues [active] 983545010853 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545010854 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 983545010855 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 983545010856 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545010857 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545010858 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545010859 L-fucose transporter; Provisional; Region: PRK10133; cl17665 983545010860 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 983545010861 galactarate dehydratase; Region: galactar-dH20; TIGR03248 983545010862 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 983545010863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545010864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545010865 active site 983545010866 catalytic tetrad [active] 983545010867 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 983545010868 Amidohydrolase; Region: Amidohydro_2; pfam04909 983545010869 active site 983545010870 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 983545010871 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 983545010872 putative NAD(P) binding site [chemical binding]; other site 983545010873 catalytic Zn binding site [ion binding]; other site 983545010874 structural Zn binding site [ion binding]; other site 983545010875 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545010876 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 983545010877 Sulfatase; Region: Sulfatase; cl17466 983545010878 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545010879 DNA polymerase III PolC; Validated; Region: polC; PRK00448 983545010880 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 983545010881 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 983545010882 RDD family; Region: RDD; pfam06271 983545010883 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 983545010884 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983545010885 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 983545010886 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983545010887 multifunctional aminopeptidase A; Provisional; Region: PRK00913 983545010888 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 983545010889 interface (dimer of trimers) [polypeptide binding]; other site 983545010890 Substrate-binding/catalytic site; other site 983545010891 Zn-binding sites [ion binding]; other site 983545010892 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 983545010893 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 983545010894 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 983545010895 HIGH motif; other site 983545010896 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 983545010897 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 983545010898 active site 983545010899 KMSKS motif; other site 983545010900 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 983545010901 tRNA binding surface [nucleotide binding]; other site 983545010902 anticodon binding site; other site 983545010903 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 983545010904 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 983545010905 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545010906 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 983545010907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545010908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010909 metal binding site [ion binding]; metal-binding site 983545010910 active site 983545010911 I-site; other site 983545010912 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 983545010913 MltA-interacting protein MipA; Region: MipA; cl01504 983545010914 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 983545010915 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 983545010916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545010917 active site 983545010918 phosphorylation site [posttranslational modification] 983545010919 intermolecular recognition site; other site 983545010920 dimerization interface [polypeptide binding]; other site 983545010921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545010922 DNA binding site [nucleotide binding] 983545010923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545010924 dimer interface [polypeptide binding]; other site 983545010925 phosphorylation site [posttranslational modification] 983545010926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010927 ATP binding site [chemical binding]; other site 983545010928 Mg2+ binding site [ion binding]; other site 983545010929 G-X-G motif; other site 983545010930 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 983545010931 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 983545010932 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 983545010933 serine/threonine protein kinase; Provisional; Region: PRK11768 983545010934 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 983545010935 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 983545010936 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 983545010937 catalytic residues [active] 983545010938 hinge region; other site 983545010939 alpha helical domain; other site 983545010940 MASE1; Region: MASE1; cl17823 983545010941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545010942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010943 metal binding site [ion binding]; metal-binding site 983545010944 active site 983545010945 I-site; other site 983545010946 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 983545010947 ligand binding site [chemical binding]; other site 983545010948 active site 983545010949 UGI interface [polypeptide binding]; other site 983545010950 catalytic site [active] 983545010951 threonine synthase; Validated; Region: PRK09225 983545010952 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 983545010953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545010954 catalytic residue [active] 983545010955 homoserine kinase; Provisional; Region: PRK01212 983545010956 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 983545010957 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 983545010958 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 983545010959 putative catalytic residues [active] 983545010960 putative nucleotide binding site [chemical binding]; other site 983545010961 putative aspartate binding site [chemical binding]; other site 983545010962 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 983545010963 dimer interface [polypeptide binding]; other site 983545010964 putative threonine allosteric regulatory site; other site 983545010965 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 983545010966 putative threonine allosteric regulatory site; other site 983545010967 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 983545010968 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 983545010969 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 983545010970 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983545010971 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 983545010972 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545010973 putative NAD(P) binding site [chemical binding]; other site 983545010974 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545010975 Ycf48-like protein; Provisional; Region: PRK13684 983545010976 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545010977 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545010978 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 983545010979 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 983545010980 acyl-activating enzyme (AAE) consensus motif; other site 983545010981 putative AMP binding site [chemical binding]; other site 983545010982 putative active site [active] 983545010983 putative CoA binding site [chemical binding]; other site 983545010984 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 983545010985 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 983545010986 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545010987 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 983545010988 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 983545010989 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 983545010990 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 983545010991 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545010992 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 983545010993 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545010994 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545010995 NAD(P) binding site [chemical binding]; other site 983545010996 substrate binding site [chemical binding]; other site 983545010997 dimer interface [polypeptide binding]; other site 983545010998 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 983545010999 AAA ATPase domain; Region: AAA_16; pfam13191 983545011000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 983545011001 DNA binding residues [nucleotide binding] 983545011002 dimerization interface [polypeptide binding]; other site 983545011003 Transposase; Region: HTH_Tnp_1; pfam01527 983545011004 glycine dehydrogenase; Provisional; Region: PRK05367 983545011005 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 983545011006 tetramer interface [polypeptide binding]; other site 983545011007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545011008 catalytic residue [active] 983545011009 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 983545011010 tetramer interface [polypeptide binding]; other site 983545011011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545011012 catalytic residue [active] 983545011013 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 983545011014 lipoyl attachment site [posttranslational modification]; other site 983545011015 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 983545011016 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 983545011017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545011018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545011019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011020 dimerization interface [polypeptide binding]; other site 983545011021 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 983545011022 Haemolysin-III related; Region: HlyIII; cl03831 983545011023 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 983545011024 WYL domain; Region: WYL; pfam13280 983545011025 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 983545011026 GIY-YIG motif/motif A; other site 983545011027 putative active site [active] 983545011028 putative metal binding site [ion binding]; other site 983545011029 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 983545011030 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545011031 metal binding triad; other site 983545011032 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545011033 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545011034 metal binding triad; other site 983545011035 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545011036 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 983545011037 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 983545011038 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 983545011039 putative acyl-acceptor binding pocket; other site 983545011040 PAS domain; Region: PAS_9; pfam13426 983545011041 PAS fold; Region: PAS_3; pfam08447 983545011042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545011043 heme pocket [chemical binding]; other site 983545011044 putative active site [active] 983545011045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545011046 PAS domain; Region: PAS_9; pfam13426 983545011047 putative active site [active] 983545011048 heme pocket [chemical binding]; other site 983545011049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545011050 PAS domain; Region: PAS_9; pfam13426 983545011051 putative active site [active] 983545011052 heme pocket [chemical binding]; other site 983545011053 PAS fold; Region: PAS_3; pfam08447 983545011054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545011055 dimer interface [polypeptide binding]; other site 983545011056 phosphorylation site [posttranslational modification] 983545011057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011058 ATP binding site [chemical binding]; other site 983545011059 Mg2+ binding site [ion binding]; other site 983545011060 G-X-G motif; other site 983545011061 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011063 active site 983545011064 phosphorylation site [posttranslational modification] 983545011065 intermolecular recognition site; other site 983545011066 dimerization interface [polypeptide binding]; other site 983545011067 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545011068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011069 active site 983545011070 phosphorylation site [posttranslational modification] 983545011071 intermolecular recognition site; other site 983545011072 dimerization interface [polypeptide binding]; other site 983545011073 Protein of unknown function (DUF3081); Region: DUF3081; pfam11280 983545011074 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545011075 Beta-lactamase; Region: Beta-lactamase; pfam00144 983545011076 cation transport regulator; Reviewed; Region: chaB; PRK09582 983545011077 Protein of unknown function (DUF808); Region: DUF808; pfam05661 983545011078 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 983545011079 putative active site [active] 983545011080 putative catalytic site [active] 983545011081 NodB motif; other site 983545011082 Zn binding site [ion binding]; other site 983545011083 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 983545011084 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545011085 phosphoglyceromutase; Provisional; Region: PRK05434 983545011086 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 983545011087 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545011088 active site residue [active] 983545011089 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 983545011090 GSH binding site [chemical binding]; other site 983545011091 catalytic residues [active] 983545011092 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 983545011093 SecA binding site; other site 983545011094 Preprotein binding site; other site 983545011095 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 983545011096 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 983545011097 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 983545011098 Predicted membrane protein [Function unknown]; Region: COG4682 983545011099 yiaA/B two helix domain; Region: YiaAB; pfam05360 983545011100 yiaA/B two helix domain; Region: YiaAB; pfam05360 983545011101 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 983545011102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545011103 non-specific DNA binding site [nucleotide binding]; other site 983545011104 salt bridge; other site 983545011105 sequence-specific DNA binding site [nucleotide binding]; other site 983545011106 hypothetical protein; Validated; Region: PRK02101 983545011107 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 983545011108 transaldolase-like protein; Provisional; Region: PTZ00411 983545011109 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 983545011110 active site 983545011111 dimer interface [polypeptide binding]; other site 983545011112 catalytic residue [active] 983545011113 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 983545011114 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 983545011115 active site 983545011116 dimer interface [polypeptide binding]; other site 983545011117 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 983545011118 dimer interface [polypeptide binding]; other site 983545011119 active site 983545011120 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 983545011121 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 983545011122 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545011123 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545011124 transcriptional regulator SlyA; Provisional; Region: PRK03573 983545011125 MarR family; Region: MarR_2; pfam12802 983545011126 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 983545011127 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011128 N-terminal plug; other site 983545011129 ligand-binding site [chemical binding]; other site 983545011130 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 983545011131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545011132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545011133 homodimer interface [polypeptide binding]; other site 983545011134 catalytic residue [active] 983545011135 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011137 active site 983545011138 phosphorylation site [posttranslational modification] 983545011139 intermolecular recognition site; other site 983545011140 dimerization interface [polypeptide binding]; other site 983545011141 DNA polymerase II; Reviewed; Region: PRK05762 983545011142 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 983545011143 active site 983545011144 catalytic site [active] 983545011145 substrate binding site [chemical binding]; other site 983545011146 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 983545011147 active site 983545011148 metal-binding site 983545011149 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545011150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011151 metal binding site [ion binding]; metal-binding site 983545011152 active site 983545011153 I-site; other site 983545011154 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545011155 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 983545011156 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545011157 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 983545011158 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 983545011159 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 983545011160 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 983545011161 GTP/Mg2+ binding site [chemical binding]; other site 983545011162 G4 box; other site 983545011163 G5 box; other site 983545011164 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 983545011165 G1 box; other site 983545011166 Switch I region; other site 983545011167 G2 box; other site 983545011168 G3 box; other site 983545011169 Switch II region; other site 983545011170 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545011171 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011172 N-terminal plug; other site 983545011173 ligand-binding site [chemical binding]; other site 983545011174 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 983545011175 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545011176 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011177 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011178 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545011179 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545011180 classical (c) SDRs; Region: SDR_c; cd05233 983545011181 NAD(P) binding site [chemical binding]; other site 983545011182 active site 983545011183 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 983545011184 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 983545011185 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 983545011186 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 983545011187 ATP-binding site [chemical binding]; other site 983545011188 Gluconate-6-phosphate binding site [chemical binding]; other site 983545011189 Shikimate kinase; Region: SKI; pfam01202 983545011190 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545011191 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 983545011192 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 983545011193 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 983545011194 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 983545011195 mannonate dehydratase; Provisional; Region: PRK03906 983545011196 mannonate dehydratase; Region: uxuA; TIGR00695 983545011197 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545011198 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011199 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011200 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 983545011201 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 983545011202 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 983545011203 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545011204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545011205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011206 metal binding site [ion binding]; metal-binding site 983545011207 active site 983545011208 I-site; other site 983545011209 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 983545011210 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 983545011211 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 983545011212 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 983545011213 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 983545011214 ligand binding site [chemical binding]; other site 983545011215 homodimer interface [polypeptide binding]; other site 983545011216 NAD(P) binding site [chemical binding]; other site 983545011217 trimer interface B [polypeptide binding]; other site 983545011218 trimer interface A [polypeptide binding]; other site 983545011219 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545011220 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545011221 substrate binding site [chemical binding]; other site 983545011222 ATP binding site [chemical binding]; other site 983545011223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011224 D-galactonate transporter; Region: 2A0114; TIGR00893 983545011225 putative substrate translocation pore; other site 983545011226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011227 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 983545011228 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545011229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545011230 DNA-binding site [nucleotide binding]; DNA binding site 983545011231 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 983545011232 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545011233 classical (c) SDRs; Region: SDR_c; cd05233 983545011234 NAD(P) binding site [chemical binding]; other site 983545011235 active site 983545011236 FAD binding domain; Region: FAD_binding_3; pfam01494 983545011237 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 983545011238 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 983545011239 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 983545011240 Cl binding site [ion binding]; other site 983545011241 oligomer interface [polypeptide binding]; other site 983545011242 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 983545011243 RimK-like ATP-grasp domain; Region: RimK; pfam08443 983545011244 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 983545011245 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 983545011246 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011248 active site 983545011249 phosphorylation site [posttranslational modification] 983545011250 intermolecular recognition site; other site 983545011251 dimerization interface [polypeptide binding]; other site 983545011252 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545011253 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011254 metal binding site [ion binding]; metal-binding site 983545011255 active site 983545011256 I-site; other site 983545011257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545011259 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545011260 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 983545011261 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 983545011262 dimer interface [polypeptide binding]; other site 983545011263 active site 983545011264 metal binding site [ion binding]; metal-binding site 983545011265 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545011266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011267 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545011268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011269 Uncharacterized conserved protein [Function unknown]; Region: COG0398 983545011270 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 983545011271 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 983545011272 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011274 active site 983545011275 phosphorylation site [posttranslational modification] 983545011276 intermolecular recognition site; other site 983545011277 dimerization interface [polypeptide binding]; other site 983545011278 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545011279 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545011280 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 983545011281 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545011282 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545011283 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545011284 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545011285 catalytic loop [active] 983545011286 iron binding site [ion binding]; other site 983545011287 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545011288 putative S-transferase; Provisional; Region: PRK11752 983545011289 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 983545011290 C-terminal domain interface [polypeptide binding]; other site 983545011291 GSH binding site (G-site) [chemical binding]; other site 983545011292 dimer interface [polypeptide binding]; other site 983545011293 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 983545011294 dimer interface [polypeptide binding]; other site 983545011295 N-terminal domain interface [polypeptide binding]; other site 983545011296 active site 983545011297 SapC; Region: SapC; pfam07277 983545011298 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 983545011299 putative transporter; Provisional; Region: PRK10484 983545011300 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 983545011301 Na binding site [ion binding]; other site 983545011302 SapC; Region: SapC; pfam07277 983545011303 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545011304 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545011305 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011306 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011307 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 983545011308 Melibiase; Region: Melibiase; pfam02065 983545011309 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 983545011310 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 983545011311 active site 983545011312 dimer interface [polypeptide binding]; other site 983545011313 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545011314 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 983545011315 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 983545011316 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 983545011317 active site 983545011318 catalytic site [active] 983545011319 substrate binding site [chemical binding]; other site 983545011320 Predicted methyltransferases [General function prediction only]; Region: COG0313 983545011321 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 983545011322 putative SAM binding site [chemical binding]; other site 983545011323 putative homodimer interface [polypeptide binding]; other site 983545011324 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 983545011325 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 983545011326 putative ligand binding site [chemical binding]; other site 983545011327 hypothetical protein; Reviewed; Region: PRK12497 983545011328 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 983545011329 dimer interface [polypeptide binding]; other site 983545011330 active site 983545011331 BON domain; Region: BON; pfam04972 983545011332 BON domain; Region: BON; pfam04972 983545011333 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 983545011334 stringent starvation protein A; Provisional; Region: sspA; PRK09481 983545011335 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 983545011336 C-terminal domain interface [polypeptide binding]; other site 983545011337 putative GSH binding site (G-site) [chemical binding]; other site 983545011338 dimer interface [polypeptide binding]; other site 983545011339 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 983545011340 dimer interface [polypeptide binding]; other site 983545011341 N-terminal domain interface [polypeptide binding]; other site 983545011342 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 983545011343 cytochrome b; Provisional; Region: CYTB; MTH00145 983545011344 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 983545011345 Qi binding site; other site 983545011346 intrachain domain interface; other site 983545011347 interchain domain interface [polypeptide binding]; other site 983545011348 heme bH binding site [chemical binding]; other site 983545011349 heme bL binding site [chemical binding]; other site 983545011350 Qo binding site; other site 983545011351 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 983545011352 interchain domain interface [polypeptide binding]; other site 983545011353 intrachain domain interface; other site 983545011354 Qi binding site; other site 983545011355 Qo binding site; other site 983545011356 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 983545011357 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 983545011358 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 983545011359 [2Fe-2S] cluster binding site [ion binding]; other site 983545011360 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 983545011361 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 983545011362 23S rRNA interface [nucleotide binding]; other site 983545011363 L3 interface [polypeptide binding]; other site 983545011364 FOG: CBS domain [General function prediction only]; Region: COG0517 983545011365 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_27; cd04640 983545011366 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 983545011367 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 983545011368 homodimer interface [polypeptide binding]; other site 983545011369 metal binding site [ion binding]; metal-binding site 983545011370 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 983545011371 homodimer interface [polypeptide binding]; other site 983545011372 active site 983545011373 putative chemical substrate binding site [chemical binding]; other site 983545011374 metal binding site [ion binding]; metal-binding site 983545011375 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 983545011376 HD domain; Region: HD_4; pfam13328 983545011377 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 983545011378 synthetase active site [active] 983545011379 NTP binding site [chemical binding]; other site 983545011380 metal binding site [ion binding]; metal-binding site 983545011381 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 983545011382 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 983545011383 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 983545011384 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 983545011385 active site 983545011386 hydrophilic channel; other site 983545011387 dimerization interface [polypeptide binding]; other site 983545011388 catalytic residues [active] 983545011389 active site lid [active] 983545011390 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 983545011391 Recombination protein O N terminal; Region: RecO_N; pfam11967 983545011392 Recombination protein O C terminal; Region: RecO_C; pfam02565 983545011393 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 983545011394 DHH family; Region: DHH; pfam01368 983545011395 DHHA1 domain; Region: DHHA1; pfam02272 983545011396 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 983545011397 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 983545011398 dimerization domain [polypeptide binding]; other site 983545011399 dimer interface [polypeptide binding]; other site 983545011400 catalytic residues [active] 983545011401 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 983545011402 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 983545011403 active site 983545011404 Int/Topo IB signature motif; other site 983545011405 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 983545011406 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 983545011407 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 983545011408 Walker A motif; other site 983545011409 ATP binding site [chemical binding]; other site 983545011410 Walker B motif; other site 983545011411 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 983545011412 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 983545011413 Walker A motif; other site 983545011414 ATP binding site [chemical binding]; other site 983545011415 Walker B motif; other site 983545011416 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 983545011417 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545011418 catalytic residue [active] 983545011419 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 983545011420 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 983545011421 YGGT family; Region: YGGT; pfam02325 983545011422 YGGT family; Region: YGGT; pfam02325 983545011423 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 983545011424 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 983545011425 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 983545011426 HAMP domain; Region: HAMP; pfam00672 983545011427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545011428 dimer interface [polypeptide binding]; other site 983545011429 phosphorylation site [posttranslational modification] 983545011430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011431 ATP binding site [chemical binding]; other site 983545011432 Mg2+ binding site [ion binding]; other site 983545011433 G-X-G motif; other site 983545011434 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011436 active site 983545011437 phosphorylation site [posttranslational modification] 983545011438 intermolecular recognition site; other site 983545011439 dimerization interface [polypeptide binding]; other site 983545011440 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545011441 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 983545011442 putative dimerization interface [polypeptide binding]; other site 983545011443 putative ligand binding site [chemical binding]; other site 983545011444 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545011445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011446 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 983545011447 xylulokinase; Provisional; Region: PRK15027 983545011448 N- and C-terminal domain interface [polypeptide binding]; other site 983545011449 active site 983545011450 MgATP binding site [chemical binding]; other site 983545011451 catalytic site [active] 983545011452 metal binding site [ion binding]; metal-binding site 983545011453 xylulose binding site [chemical binding]; other site 983545011454 homodimer interface [polypeptide binding]; other site 983545011455 xylose isomerase; Provisional; Region: PRK05474 983545011456 xylose isomerase; Region: xylose_isom_A; TIGR02630 983545011457 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 983545011458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011459 putative substrate translocation pore; other site 983545011460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011461 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 983545011462 substrate binding site [chemical binding]; other site 983545011463 active site 983545011464 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 983545011465 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 983545011466 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 983545011467 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 983545011468 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 983545011469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545011470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545011471 DNA binding site [nucleotide binding] 983545011472 domain linker motif; other site 983545011473 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545011474 dimerization interface (closed form) [polypeptide binding]; other site 983545011475 ligand binding site [chemical binding]; other site 983545011476 putative symporter YagG; Provisional; Region: PRK09669 983545011477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011478 putative substrate translocation pore; other site 983545011479 beta-galactosidase; Region: BGL; TIGR03356 983545011480 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 983545011481 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545011482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011483 putative substrate translocation pore; other site 983545011484 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 983545011485 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 983545011486 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545011487 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545011488 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011489 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011490 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 983545011491 SapC; Region: SapC; pfam07277 983545011492 Cupin-like domain; Region: Cupin_8; pfam13621 983545011493 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545011494 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545011495 putative catalytic site [active] 983545011496 putative metal binding site [ion binding]; other site 983545011497 putative phosphate binding site [ion binding]; other site 983545011498 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 983545011499 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 983545011500 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 983545011501 putative active site [active] 983545011502 putative active site [active] 983545011503 catalytic site [active] 983545011504 catalytic site [active] 983545011505 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 983545011506 putative active site [active] 983545011507 catalytic site [active] 983545011508 Uncharacterized conserved protein [Function unknown]; Region: COG0398 983545011509 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 983545011510 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 983545011511 DNA-binding site [nucleotide binding]; DNA binding site 983545011512 RNA-binding motif; other site 983545011513 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 983545011514 dimer interface [polypeptide binding]; other site 983545011515 catalytic triad [active] 983545011516 peroxidatic and resolving cysteines [active] 983545011517 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 983545011518 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 983545011519 NADP+ binding site [chemical binding]; other site 983545011520 folate binding site [chemical binding]; other site 983545011521 GTPase CgtA; Reviewed; Region: obgE; PRK12298 983545011522 GTP1/OBG; Region: GTP1_OBG; pfam01018 983545011523 Obg GTPase; Region: Obg; cd01898 983545011524 G1 box; other site 983545011525 GTP/Mg2+ binding site [chemical binding]; other site 983545011526 Switch I region; other site 983545011527 G2 box; other site 983545011528 G3 box; other site 983545011529 Switch II region; other site 983545011530 G4 box; other site 983545011531 G5 box; other site 983545011532 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 983545011533 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 983545011534 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 983545011535 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 983545011536 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 983545011537 substrate binding pocket [chemical binding]; other site 983545011538 chain length determination region; other site 983545011539 substrate-Mg2+ binding site; other site 983545011540 catalytic residues [active] 983545011541 aspartate-rich region 1; other site 983545011542 active site lid residues [active] 983545011543 aspartate-rich region 2; other site 983545011544 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983545011545 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011546 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011547 Uncharacterized conserved protein [Function unknown]; Region: COG3595 983545011548 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 983545011549 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 983545011550 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 983545011551 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545011552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545011553 DNA binding residues [nucleotide binding] 983545011554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 983545011555 MOSC domain; Region: MOSC; pfam03473 983545011556 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 983545011557 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 983545011558 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 983545011559 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 983545011560 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 983545011561 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 983545011562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545011563 putative active site [active] 983545011564 heme pocket [chemical binding]; other site 983545011565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545011566 dimer interface [polypeptide binding]; other site 983545011567 phosphorylation site [posttranslational modification] 983545011568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011569 ATP binding site [chemical binding]; other site 983545011570 Mg2+ binding site [ion binding]; other site 983545011571 G-X-G motif; other site 983545011572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011573 active site 983545011574 phosphorylation site [posttranslational modification] 983545011575 intermolecular recognition site; other site 983545011576 dimerization interface [polypeptide binding]; other site 983545011577 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545011578 putative binding surface; other site 983545011579 active site 983545011580 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 983545011581 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 983545011582 active site 983545011583 dimer interface [polypeptide binding]; other site 983545011584 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 983545011585 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 983545011586 active site 983545011587 FMN binding site [chemical binding]; other site 983545011588 substrate binding site [chemical binding]; other site 983545011589 3Fe-4S cluster binding site [ion binding]; other site 983545011590 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 983545011591 domain interface; other site 983545011592 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 983545011593 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 983545011594 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 983545011595 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 983545011596 putative active site [active] 983545011597 metal binding site [ion binding]; metal-binding site 983545011598 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 983545011599 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 983545011600 catalytic residues [active] 983545011601 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 983545011602 oligomerisation interface [polypeptide binding]; other site 983545011603 mobile loop; other site 983545011604 roof hairpin; other site 983545011605 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 983545011606 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 983545011607 ring oligomerisation interface [polypeptide binding]; other site 983545011608 ATP/Mg binding site [chemical binding]; other site 983545011609 stacking interactions; other site 983545011610 hinge regions; other site 983545011611 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 983545011612 multiple promoter invertase; Provisional; Region: mpi; PRK13413 983545011613 catalytic residues [active] 983545011614 catalytic nucleophile [active] 983545011615 Presynaptic Site I dimer interface [polypeptide binding]; other site 983545011616 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 983545011617 Synaptic Flat tetramer interface [polypeptide binding]; other site 983545011618 Synaptic Site I dimer interface [polypeptide binding]; other site 983545011619 DNA binding site [nucleotide binding] 983545011620 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545011621 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545011622 active site 983545011623 DNA binding site [nucleotide binding] 983545011624 Int/Topo IB signature motif; other site 983545011625 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 983545011626 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 983545011627 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545011628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545011629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011630 metal binding site [ion binding]; metal-binding site 983545011631 active site 983545011632 I-site; other site 983545011633 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 983545011634 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 983545011635 Walker A/P-loop; other site 983545011636 ATP binding site [chemical binding]; other site 983545011637 Q-loop/lid; other site 983545011638 ABC transporter signature motif; other site 983545011639 Walker B; other site 983545011640 D-loop; other site 983545011641 H-loop/switch region; other site 983545011642 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 983545011643 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 983545011644 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 983545011645 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 983545011646 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545011647 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011648 N-terminal plug; other site 983545011649 ligand-binding site [chemical binding]; other site 983545011650 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 983545011651 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 983545011652 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 983545011653 active site 983545011654 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 983545011655 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 983545011656 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011657 N-terminal plug; other site 983545011658 ligand-binding site [chemical binding]; other site 983545011659 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 983545011660 Cytochrome b562; Region: Cytochrom_B562; cl01546 983545011661 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 983545011662 membrane-bound complex binding site; other site 983545011663 hinge residues; other site 983545011664 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 983545011665 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 983545011666 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 983545011667 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545011668 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011669 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545011670 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 983545011671 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545011672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011673 TPR motif; other site 983545011674 binding surface 983545011675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011676 binding surface 983545011677 TPR motif; other site 983545011678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011679 binding surface 983545011680 TPR motif; other site 983545011681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011682 TPR motif; other site 983545011683 binding surface 983545011684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011685 binding surface 983545011686 TPR motif; other site 983545011687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011688 TPR motif; other site 983545011689 binding surface 983545011690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011691 TPR motif; other site 983545011692 binding surface 983545011693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011694 binding surface 983545011695 TPR motif; other site 983545011696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545011697 binding surface 983545011698 TPR motif; other site 983545011699 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 983545011700 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 983545011701 Protein export membrane protein; Region: SecD_SecF; cl14618 983545011702 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 983545011703 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545011704 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545011705 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 983545011706 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 983545011707 hypothetical protein; Provisional; Region: PRK07236 983545011708 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 983545011709 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 983545011710 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 983545011711 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 983545011712 acyl-activating enzyme (AAE) consensus motif; other site 983545011713 putative AMP binding site [chemical binding]; other site 983545011714 putative active site [active] 983545011715 putative CoA binding site [chemical binding]; other site 983545011716 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545011717 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011718 substrate binding site [chemical binding]; other site 983545011719 oxyanion hole (OAH) forming residues; other site 983545011720 trimer interface [polypeptide binding]; other site 983545011721 MarR family; Region: MarR_2; cl17246 983545011722 5-oxoprolinase; Region: PLN02666 983545011723 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545011724 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 983545011725 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 983545011726 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 983545011727 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 983545011728 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 983545011729 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545011730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011731 putative substrate translocation pore; other site 983545011732 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545011733 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011734 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545011735 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 983545011736 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545011737 active site 983545011738 catalytic site [active] 983545011739 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 983545011740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545011741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545011742 DNA binding site [nucleotide binding] 983545011743 domain linker motif; other site 983545011744 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 983545011745 putative ligand binding site [chemical binding]; other site 983545011746 putative dimerization interface [polypeptide binding]; other site 983545011747 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545011748 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 983545011749 C-terminal domain interface [polypeptide binding]; other site 983545011750 GSH binding site (G-site) [chemical binding]; other site 983545011751 dimer interface [polypeptide binding]; other site 983545011752 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545011753 N-terminal domain interface [polypeptide binding]; other site 983545011754 dimer interface [polypeptide binding]; other site 983545011755 substrate binding pocket (H-site) [chemical binding]; other site 983545011756 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 983545011757 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 983545011758 putative active site [active] 983545011759 PhoH-like protein; Region: PhoH; pfam02562 983545011760 ATP-dependent helicase HepA; Validated; Region: PRK04914 983545011761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545011762 ATP binding site [chemical binding]; other site 983545011763 putative Mg++ binding site [ion binding]; other site 983545011764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545011765 nucleotide binding region [chemical binding]; other site 983545011766 ATP-binding site [chemical binding]; other site 983545011767 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 983545011768 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 983545011769 active site 983545011770 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 983545011771 muropeptide transporter; Reviewed; Region: ampG; PRK11902 983545011772 AmpG-like permease; Region: 2A0125; TIGR00901 983545011773 PAS fold; Region: PAS_4; pfam08448 983545011774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545011775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011776 metal binding site [ion binding]; metal-binding site 983545011777 active site 983545011778 I-site; other site 983545011779 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545011781 active site 983545011782 phosphorylation site [posttranslational modification] 983545011783 intermolecular recognition site; other site 983545011784 dimerization interface [polypeptide binding]; other site 983545011785 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 983545011786 thymidylate synthase; Reviewed; Region: thyA; PRK01827 983545011787 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 983545011788 dimerization interface [polypeptide binding]; other site 983545011789 active site 983545011790 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 983545011791 CAAX protease self-immunity; Region: Abi; pfam02517 983545011792 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 983545011793 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 983545011794 dimerization interface [polypeptide binding]; other site 983545011795 DPS ferroxidase diiron center [ion binding]; other site 983545011796 ion pore; other site 983545011797 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 983545011798 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 983545011799 NADP binding site [chemical binding]; other site 983545011800 active site 983545011801 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 983545011802 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545011803 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 983545011804 GAF domain; Region: GAF; pfam01590 983545011805 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 983545011806 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 983545011807 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 983545011808 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 983545011809 putative active site [active] 983545011810 Ap4A binding site [chemical binding]; other site 983545011811 nudix motif; other site 983545011812 putative metal binding site [ion binding]; other site 983545011813 YhhN-like protein; Region: YhhN; pfam07947 983545011814 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 983545011815 putative DNA-binding cleft [nucleotide binding]; other site 983545011816 putative DNA clevage site; other site 983545011817 molecular lever; other site 983545011818 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545011819 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 983545011820 NAD(P) binding site [chemical binding]; other site 983545011821 catalytic residues [active] 983545011822 acetolactate synthase; Reviewed; Region: PRK08322 983545011823 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 983545011824 PYR/PP interface [polypeptide binding]; other site 983545011825 dimer interface [polypeptide binding]; other site 983545011826 TPP binding site [chemical binding]; other site 983545011827 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 983545011828 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 983545011829 TPP-binding site [chemical binding]; other site 983545011830 dimer interface [polypeptide binding]; other site 983545011831 Uncharacterized conserved protein [Function unknown]; Region: COG3025 983545011832 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 983545011833 putative active site [active] 983545011834 putative metal binding residues [ion binding]; other site 983545011835 signature motif; other site 983545011836 putative triphosphate binding site [ion binding]; other site 983545011837 Bacterial SH3 domain homologues; Region: SH3b; smart00287 983545011838 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 983545011839 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 983545011840 TIGR03546 family protein; Region: TIGR03546 983545011841 TIGR03545 family protein; Region: TIGR03545 983545011842 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 983545011843 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 983545011844 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 983545011845 substrate binding site; other site 983545011846 dimer interface; other site 983545011847 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 983545011848 homotrimer interaction site [polypeptide binding]; other site 983545011849 zinc binding site [ion binding]; other site 983545011850 CDP-binding sites; other site 983545011851 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 983545011852 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 983545011853 Permutation of conserved domain; other site 983545011854 active site 983545011855 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 983545011856 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 983545011857 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 983545011858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545011859 S-adenosylmethionine binding site [chemical binding]; other site 983545011860 Domain of unknown function (DUF368); Region: DUF368; pfam04018 983545011861 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 983545011862 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 983545011863 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545011864 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 983545011865 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545011866 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545011867 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983545011868 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545011869 DNA binding residues [nucleotide binding] 983545011870 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545011871 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 983545011872 putative hydrolase; Validated; Region: PRK09248 983545011873 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 983545011874 active site 983545011875 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 983545011876 nucleoside/Zn binding site; other site 983545011877 dimer interface [polypeptide binding]; other site 983545011878 catalytic motif [active] 983545011879 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545011880 non-specific DNA binding site [nucleotide binding]; other site 983545011881 salt bridge; other site 983545011882 sequence-specific DNA binding site [nucleotide binding]; other site 983545011883 Predicted amidohydrolase [General function prediction only]; Region: COG0388 983545011884 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 983545011885 putative active site [active] 983545011886 catalytic triad [active] 983545011887 putative dimer interface [polypeptide binding]; other site 983545011888 arginine decarboxylase; Provisional; Region: PRK05354 983545011889 ParB-like nuclease domain; Region: ParBc; cl02129 983545011890 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 983545011891 dimer interface [polypeptide binding]; other site 983545011892 active site 983545011893 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545011894 catalytic residues [active] 983545011895 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 983545011896 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545011897 Beta-lactamase; Region: Beta-lactamase; pfam00144 983545011898 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 983545011899 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 983545011900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011901 AlkA N-terminal domain; Region: AlkA_N; pfam06029 983545011902 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 983545011903 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 983545011904 minor groove reading motif; other site 983545011905 helix-hairpin-helix signature motif; other site 983545011906 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 983545011907 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 983545011908 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 983545011909 DNA binding site [nucleotide binding] 983545011910 active site 983545011911 EamA-like transporter family; Region: EamA; pfam00892 983545011912 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545011913 EamA-like transporter family; Region: EamA; pfam00892 983545011914 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545011915 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011916 metal binding site [ion binding]; metal-binding site 983545011917 active site 983545011918 I-site; other site 983545011919 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 983545011920 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 983545011921 Substrate binding site; other site 983545011922 Mg++ binding site; other site 983545011923 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 983545011924 active site 983545011925 substrate binding site [chemical binding]; other site 983545011926 CoA binding site [chemical binding]; other site 983545011927 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 983545011928 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 983545011929 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 983545011930 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 983545011931 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 983545011932 glutaminase active site [active] 983545011933 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 983545011934 dimer interface [polypeptide binding]; other site 983545011935 active site 983545011936 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 983545011937 dimer interface [polypeptide binding]; other site 983545011938 active site 983545011939 HsdM N-terminal domain; Region: HsdM_N; pfam12161 983545011940 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 983545011941 Methyltransferase domain; Region: Methyltransf_26; pfam13659 983545011942 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 983545011943 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 983545011944 Fic/DOC family; Region: Fic; cl00960 983545011945 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 983545011946 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 983545011947 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 983545011948 ATP binding site [chemical binding]; other site 983545011949 putative Mg++ binding site [ion binding]; other site 983545011950 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 983545011951 Helix-turn-helix domain; Region: HTH_36; pfam13730 983545011952 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 983545011953 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 983545011954 Integrase core domain; Region: rve; pfam00665 983545011955 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 983545011956 AAA domain; Region: AAA_22; pfam13401 983545011957 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 983545011958 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 983545011959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545011960 non-specific DNA binding site [nucleotide binding]; other site 983545011961 salt bridge; other site 983545011962 sequence-specific DNA binding site [nucleotide binding]; other site 983545011963 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545011964 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011965 N-terminal plug; other site 983545011966 ligand-binding site [chemical binding]; other site 983545011967 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545011968 classical (c) SDRs; Region: SDR_c; cd05233 983545011969 NAD(P) binding site [chemical binding]; other site 983545011970 active site 983545011971 hypothetical protein; Provisional; Region: PRK06194 983545011972 classical (c) SDRs; Region: SDR_c; cd05233 983545011973 NAD(P) binding site [chemical binding]; other site 983545011974 active site 983545011975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545011977 enoyl-CoA hydratase; Provisional; Region: PRK08140 983545011978 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011979 substrate binding site [chemical binding]; other site 983545011980 oxyanion hole (OAH) forming residues; other site 983545011981 trimer interface [polypeptide binding]; other site 983545011982 aldehyde dehydrogenase; Provisional; Region: PRK11903 983545011983 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 983545011984 substrate binding site [chemical binding]; other site 983545011985 dimer interface [polypeptide binding]; other site 983545011986 NADP binding site [chemical binding]; other site 983545011987 catalytic residues [active] 983545011988 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 983545011989 Strictosidine synthase; Region: Str_synth; pfam03088 983545011990 enoyl-CoA hydratase; Provisional; Region: PRK06494 983545011991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545011992 substrate binding site [chemical binding]; other site 983545011993 oxyanion hole (OAH) forming residues; other site 983545011994 trimer interface [polypeptide binding]; other site 983545011995 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 983545011996 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 983545011997 CoA-transferase family III; Region: CoA_transf_3; pfam02515 983545011998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545012000 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 983545012001 ligand binding site [chemical binding]; other site 983545012002 coregulator recognition site; other site 983545012003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012004 D-galactonate transporter; Region: 2A0114; TIGR00893 983545012005 putative substrate translocation pore; other site 983545012006 acyl-CoA synthetase; Provisional; Region: PRK12582 983545012007 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983545012008 acyl-activating enzyme (AAE) consensus motif; other site 983545012009 AMP binding site [chemical binding]; other site 983545012010 active site 983545012011 CoA binding site [chemical binding]; other site 983545012012 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 983545012013 active site 983545012014 catalytic site [active] 983545012015 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545012016 active site 2 [active] 983545012017 active site 1 [active] 983545012018 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 983545012019 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545012020 active site 983545012021 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 983545012022 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545012023 active site 983545012024 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 983545012025 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545012026 dimer interface [polypeptide binding]; other site 983545012027 active site 983545012028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545012029 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545012030 substrate binding site [chemical binding]; other site 983545012031 oxyanion hole (OAH) forming residues; other site 983545012032 trimer interface [polypeptide binding]; other site 983545012033 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983545012034 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545012035 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545012036 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 983545012037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 983545012038 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545012039 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 983545012040 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 983545012041 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545012042 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545012043 active site 983545012044 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 983545012045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545012046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012047 metal binding site [ion binding]; metal-binding site 983545012048 active site 983545012049 I-site; other site 983545012050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 983545012051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545012052 dimer interface [polypeptide binding]; other site 983545012053 phosphorylation site [posttranslational modification] 983545012054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012055 ATP binding site [chemical binding]; other site 983545012056 Mg2+ binding site [ion binding]; other site 983545012057 G-X-G motif; other site 983545012058 Response regulator receiver domain; Region: Response_reg; pfam00072 983545012059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012060 active site 983545012061 phosphorylation site [posttranslational modification] 983545012062 intermolecular recognition site; other site 983545012063 dimerization interface [polypeptide binding]; other site 983545012064 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545012065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012066 active site 983545012067 phosphorylation site [posttranslational modification] 983545012068 intermolecular recognition site; other site 983545012069 dimerization interface [polypeptide binding]; other site 983545012070 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 983545012071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545012072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545012073 dimerization interface [polypeptide binding]; other site 983545012074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 983545012075 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 983545012076 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 983545012077 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 983545012078 putative ligand binding site [chemical binding]; other site 983545012079 HAMP domain; Region: HAMP; pfam00672 983545012080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545012081 dimer interface [polypeptide binding]; other site 983545012082 phosphorylation site [posttranslational modification] 983545012083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012084 ATP binding site [chemical binding]; other site 983545012085 Mg2+ binding site [ion binding]; other site 983545012086 G-X-G motif; other site 983545012087 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 983545012088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012089 active site 983545012090 phosphorylation site [posttranslational modification] 983545012091 intermolecular recognition site; other site 983545012092 dimerization interface [polypeptide binding]; other site 983545012093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545012094 DNA binding site [nucleotide binding] 983545012095 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 983545012096 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545012097 ligand binding site [chemical binding]; other site 983545012098 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 983545012099 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 983545012100 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545012101 metal ion-dependent adhesion site (MIDAS); other site 983545012102 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 983545012103 active site 983545012104 catalytic site [active] 983545012105 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 983545012106 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983545012107 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 983545012108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545012109 Walker A/P-loop; other site 983545012110 ATP binding site [chemical binding]; other site 983545012111 Q-loop/lid; other site 983545012112 ABC transporter signature motif; other site 983545012113 Walker B; other site 983545012114 D-loop; other site 983545012115 H-loop/switch region; other site 983545012116 inner membrane transport permease; Provisional; Region: PRK15066 983545012117 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 983545012118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545012119 S-adenosylmethionine binding site [chemical binding]; other site 983545012120 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545012121 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 983545012122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545012123 catalytic residue [active] 983545012124 pantoate--beta-alanine ligase; Region: panC; TIGR00018 983545012125 Pantoate-beta-alanine ligase; Region: PanC; cd00560 983545012126 active site 983545012127 ATP-binding site [chemical binding]; other site 983545012128 pantoate-binding site; other site 983545012129 HXXH motif; other site 983545012130 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 983545012131 oligomerization interface [polypeptide binding]; other site 983545012132 active site 983545012133 metal binding site [ion binding]; metal-binding site 983545012134 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 983545012135 catalytic center binding site [active] 983545012136 ATP binding site [chemical binding]; other site 983545012137 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 983545012138 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 983545012139 active site 983545012140 NTP binding site [chemical binding]; other site 983545012141 metal binding triad [ion binding]; metal-binding site 983545012142 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 983545012143 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 983545012144 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 983545012145 active site 983545012146 HIGH motif; other site 983545012147 nucleotide binding site [chemical binding]; other site 983545012148 KMSKS motif; other site 983545012149 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 983545012150 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 983545012151 aminopeptidase B; Provisional; Region: PRK05015 983545012152 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 983545012153 interface (dimer of trimers) [polypeptide binding]; other site 983545012154 Substrate-binding/catalytic site; other site 983545012155 Zn-binding sites [ion binding]; other site 983545012156 Helix-turn-helix domain; Region: HTH_17; cl17695 983545012157 MarC family integral membrane protein; Region: MarC; cl00919 983545012158 Protein of unknown function (DUF416); Region: DUF416; pfam04222 983545012159 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 983545012160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545012161 S-adenosylmethionine binding site [chemical binding]; other site 983545012162 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 983545012163 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 983545012164 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 983545012165 P loop; other site 983545012166 GTP binding site [chemical binding]; other site 983545012167 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 983545012168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545012169 Walker A/P-loop; other site 983545012170 ATP binding site [chemical binding]; other site 983545012171 Q-loop/lid; other site 983545012172 ABC transporter signature motif; other site 983545012173 Walker B; other site 983545012174 D-loop; other site 983545012175 H-loop/switch region; other site 983545012176 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 983545012177 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 983545012178 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 983545012179 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545012180 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 983545012181 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545012182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545012183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545012184 DNA binding residues [nucleotide binding] 983545012185 acyl-CoA synthetase; Validated; Region: PRK08316 983545012186 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983545012187 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983545012188 acyl-activating enzyme (AAE) consensus motif; other site 983545012189 acyl-activating enzyme (AAE) consensus motif; other site 983545012190 AMP binding site [chemical binding]; other site 983545012191 active site 983545012192 CoA binding site [chemical binding]; other site 983545012193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012194 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545012195 NAD(P) binding site [chemical binding]; other site 983545012196 active site 983545012197 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 983545012198 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 983545012199 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545012200 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 983545012201 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 983545012202 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545012203 carboxyltransferase (CT) interaction site; other site 983545012204 biotinylation site [posttranslational modification]; other site 983545012205 enoyl-CoA hydratase; Provisional; Region: PRK05995 983545012206 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545012207 substrate binding site [chemical binding]; other site 983545012208 oxyanion hole (OAH) forming residues; other site 983545012209 trimer interface [polypeptide binding]; other site 983545012210 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 983545012211 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 983545012212 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 983545012213 FMN binding site [chemical binding]; other site 983545012214 substrate binding site [chemical binding]; other site 983545012215 putative catalytic residue [active] 983545012216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545012217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545012218 active site 983545012219 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545012220 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545012221 conserved cys residue [active] 983545012222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545012223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545012224 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 983545012225 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545012226 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 983545012227 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 983545012228 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545012229 N-terminal plug; other site 983545012230 ligand-binding site [chemical binding]; other site 983545012231 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 983545012232 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 983545012233 active site 983545012234 HIGH motif; other site 983545012235 dimer interface [polypeptide binding]; other site 983545012236 KMSKS motif; other site 983545012237 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 983545012238 Predicted flavoprotein [General function prediction only]; Region: COG0431 983545012239 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 983545012240 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983545012241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 983545012242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545012243 Walker A/P-loop; other site 983545012244 ATP binding site [chemical binding]; other site 983545012245 Q-loop/lid; other site 983545012246 ABC transporter signature motif; other site 983545012247 Walker B; other site 983545012248 D-loop; other site 983545012249 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545012250 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545012251 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545012252 Outer membrane efflux protein; Region: OEP; pfam02321 983545012253 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 983545012254 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 983545012255 glutamate dehydrogenase; Provisional; Region: PRK09414 983545012256 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983545012257 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 983545012258 NAD(P) binding site [chemical binding]; other site 983545012259 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 983545012260 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 983545012261 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 983545012262 Na binding site [ion binding]; other site 983545012263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545012264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 983545012265 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 983545012266 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 983545012267 metal binding site [ion binding]; metal-binding site 983545012268 substrate binding pocket [chemical binding]; other site 983545012269 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545012270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545012271 DNA binding site [nucleotide binding] 983545012272 domain linker motif; other site 983545012273 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 983545012274 dimerization interface [polypeptide binding]; other site 983545012275 ligand binding site [chemical binding]; other site 983545012276 BCCT family transporter; Region: BCCT; cl00569 983545012277 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 983545012278 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 983545012279 MAPEG family; Region: MAPEG; pfam01124 983545012280 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 983545012281 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 983545012282 cofactor binding site; other site 983545012283 DNA binding site [nucleotide binding] 983545012284 substrate interaction site [chemical binding]; other site 983545012285 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 983545012286 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 983545012287 AIPR protein; Region: AIPR; pfam10592 983545012288 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 983545012289 Z1 domain; Region: Z1; pfam10593 983545012290 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 983545012291 Methyltransferase domain; Region: Methyltransf_31; pfam13847 983545012292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545012293 S-adenosylmethionine binding site [chemical binding]; other site 983545012294 HNH endonuclease; Region: HNH_4; pfam13395 983545012295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545012296 non-specific DNA binding site [nucleotide binding]; other site 983545012297 salt bridge; other site 983545012298 sequence-specific DNA binding site [nucleotide binding]; other site 983545012299 HipA N-terminal domain; Region: Couple_hipA; cl11853 983545012300 HipA-like N-terminal domain; Region: HipA_N; pfam07805 983545012301 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545012302 Secretin and TonB N terminus short domain; Region: STN; pfam07660 983545012303 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545012304 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545012305 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545012306 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545012307 FecR protein; Region: FecR; pfam04773 983545012308 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 983545012309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545012310 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 983545012311 DNA binding residues [nucleotide binding] 983545012312 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545012313 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 983545012314 active site 983545012315 metal binding site [ion binding]; metal-binding site 983545012316 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545012317 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545012318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545012319 dimerization interface [polypeptide binding]; other site 983545012320 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545012321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012322 metal binding site [ion binding]; metal-binding site 983545012323 active site 983545012324 I-site; other site 983545012325 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545012326 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 983545012327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 983545012328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545012329 putative PBP binding loops; other site 983545012330 ABC-ATPase subunit interface; other site 983545012331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 983545012332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 983545012333 dimer interface [polypeptide binding]; other site 983545012334 conserved gate region; other site 983545012335 putative PBP binding loops; other site 983545012336 ABC-ATPase subunit interface; other site 983545012337 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 983545012338 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 983545012339 Walker A/P-loop; other site 983545012340 ATP binding site [chemical binding]; other site 983545012341 Q-loop/lid; other site 983545012342 ABC transporter signature motif; other site 983545012343 Walker B; other site 983545012344 D-loop; other site 983545012345 H-loop/switch region; other site 983545012346 TOBE domain; Region: TOBE_2; pfam08402 983545012347 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 983545012348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 983545012349 motif I; other site 983545012350 active site 983545012351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545012352 motif II; other site 983545012353 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 983545012354 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 983545012355 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 983545012356 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 983545012357 putative substrate binding site [chemical binding]; other site 983545012358 putative ATP binding site [chemical binding]; other site 983545012359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545012360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545012361 LysR substrate binding domain; Region: LysR_substrate; pfam03466 983545012362 dimerization interface [polypeptide binding]; other site 983545012363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545012364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545012365 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545012366 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545012367 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545012368 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 983545012369 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 983545012370 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545012371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012372 putative substrate translocation pore; other site 983545012373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545012374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545012375 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545012376 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 983545012377 putative C-terminal domain interface [polypeptide binding]; other site 983545012378 putative GSH binding site (G-site) [chemical binding]; other site 983545012379 putative dimer interface [polypeptide binding]; other site 983545012380 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545012381 N-terminal domain interface [polypeptide binding]; other site 983545012382 dimer interface [polypeptide binding]; other site 983545012383 substrate binding pocket (H-site) [chemical binding]; other site 983545012384 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 983545012385 periplasmic protein; Provisional; Region: PRK10568 983545012386 BON domain; Region: BON; pfam04972 983545012387 BON domain; Region: BON; pfam04972 983545012388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545012389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 983545012390 active site 983545012391 catalytic tetrad [active] 983545012392 Predicted membrane protein [Function unknown]; Region: COG4325 983545012393 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 983545012394 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545012395 putative catalytic site [active] 983545012396 putative metal binding site [ion binding]; other site 983545012397 putative phosphate binding site [ion binding]; other site 983545012398 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545012399 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 983545012400 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 983545012401 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545012402 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545012403 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 983545012404 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 983545012405 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 983545012406 putative catalytic cysteine [active] 983545012407 gamma-glutamyl kinase; Provisional; Region: PRK13402 983545012408 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 983545012409 nucleotide binding site [chemical binding]; other site 983545012410 homotetrameric interface [polypeptide binding]; other site 983545012411 putative phosphate binding site [ion binding]; other site 983545012412 putative allosteric binding site; other site 983545012413 PUA domain; Region: PUA; pfam01472 983545012414 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 983545012415 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545012416 Na binding site [ion binding]; other site 983545012417 Transcriptional regulators [Transcription]; Region: MarR; COG1846 983545012418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545012419 putative DNA binding site [nucleotide binding]; other site 983545012420 VacJ like lipoprotein; Region: VacJ; cl01073 983545012421 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545012422 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545012423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012424 active site 983545012425 phosphorylation site [posttranslational modification] 983545012426 intermolecular recognition site; other site 983545012427 dimerization interface [polypeptide binding]; other site 983545012428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545012429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545012430 dimer interface [polypeptide binding]; other site 983545012431 phosphorylation site [posttranslational modification] 983545012432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012433 ATP binding site [chemical binding]; other site 983545012434 Mg2+ binding site [ion binding]; other site 983545012435 G-X-G motif; other site 983545012436 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545012437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012438 active site 983545012439 phosphorylation site [posttranslational modification] 983545012440 intermolecular recognition site; other site 983545012441 dimerization interface [polypeptide binding]; other site 983545012442 Response regulator receiver domain; Region: Response_reg; pfam00072 983545012443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012444 active site 983545012445 phosphorylation site [posttranslational modification] 983545012446 intermolecular recognition site; other site 983545012447 dimerization interface [polypeptide binding]; other site 983545012448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012449 Response regulator receiver domain; Region: Response_reg; pfam00072 983545012450 active site 983545012451 phosphorylation site [posttranslational modification] 983545012452 intermolecular recognition site; other site 983545012453 dimerization interface [polypeptide binding]; other site 983545012454 CHASE3 domain; Region: CHASE3; pfam05227 983545012455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545012456 dimer interface [polypeptide binding]; other site 983545012457 phosphorylation site [posttranslational modification] 983545012458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012459 ATP binding site [chemical binding]; other site 983545012460 Mg2+ binding site [ion binding]; other site 983545012461 G-X-G motif; other site 983545012462 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545012463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012464 active site 983545012465 phosphorylation site [posttranslational modification] 983545012466 intermolecular recognition site; other site 983545012467 dimerization interface [polypeptide binding]; other site 983545012468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545012469 Walker A motif; other site 983545012470 ATP binding site [chemical binding]; other site 983545012471 Walker B motif; other site 983545012472 arginine finger; other site 983545012473 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 983545012474 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 983545012475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545012476 Coenzyme A binding pocket [chemical binding]; other site 983545012477 Peptidase_C39 like family; Region: DUF3335; pfam11814 983545012478 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 983545012479 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 983545012480 ATP-grasp domain; Region: ATP-grasp_4; cl17255 983545012481 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545012482 Beta-lactamase; Region: Beta-lactamase; pfam00144 983545012483 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 983545012484 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 983545012485 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 983545012486 amidase catalytic site [active] 983545012487 Zn binding residues [ion binding]; other site 983545012488 substrate binding site [chemical binding]; other site 983545012489 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 983545012490 Beta-lactamase; Region: Beta-lactamase; cl17358 983545012491 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545012492 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 983545012493 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 983545012494 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 983545012495 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 983545012496 nudix motif; other site 983545012497 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 983545012498 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 983545012499 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 983545012500 putative active site [active] 983545012501 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545012502 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545012503 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545012504 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 983545012505 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 983545012506 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 983545012507 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 983545012508 putative active site [active] 983545012509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 983545012510 nucleotide binding site [chemical binding]; other site 983545012511 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 983545012512 Na binding site [ion binding]; other site 983545012513 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 983545012514 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 983545012515 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 983545012516 NlpC/P60 family; Region: NLPC_P60; cl17555 983545012517 Predicted integral membrane protein [Function unknown]; Region: COG5505 983545012518 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 983545012519 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 983545012520 dimer interface [polypeptide binding]; other site 983545012521 active site 983545012522 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 983545012523 dimer interface [polypeptide binding]; other site 983545012524 active site 983545012525 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 983545012526 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 983545012527 active site 983545012528 dimer interface [polypeptide binding]; other site 983545012529 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545012530 L-fucose transporter; Provisional; Region: PRK10133; cl17665 983545012531 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 983545012532 dimer interface [polypeptide binding]; other site 983545012533 catalytic triad [active] 983545012534 Response regulator receiver domain; Region: Response_reg; pfam00072 983545012535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012536 active site 983545012537 phosphorylation site [posttranslational modification] 983545012538 intermolecular recognition site; other site 983545012539 dimerization interface [polypeptide binding]; other site 983545012540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545012541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012542 metal binding site [ion binding]; metal-binding site 983545012543 active site 983545012544 I-site; other site 983545012545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 983545012546 phosphorylation site [posttranslational modification] 983545012547 dimer interface [polypeptide binding]; other site 983545012548 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 983545012549 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545012550 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545012551 ABC transporter; Region: ABC_tran_2; pfam12848 983545012552 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545012553 TQO small subunit DoxD; Region: DoxD; pfam04173 983545012554 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545012555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545012556 dimer interface [polypeptide binding]; other site 983545012557 putative CheW interface [polypeptide binding]; other site 983545012558 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 983545012559 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545012560 dimer interface [polypeptide binding]; other site 983545012561 putative CheW interface [polypeptide binding]; other site 983545012562 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 983545012563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 983545012564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545012565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545012566 WHG domain; Region: WHG; pfam13305 983545012567 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 983545012568 Malic enzyme, N-terminal domain; Region: malic; pfam00390 983545012569 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 983545012570 putative NAD(P) binding site [chemical binding]; other site 983545012571 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 983545012572 primosome assembly protein PriA; Validated; Region: PRK05580 983545012573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545012574 ATP binding site [chemical binding]; other site 983545012575 putative Mg++ binding site [ion binding]; other site 983545012576 helicase superfamily c-terminal domain; Region: HELICc; smart00490 983545012577 ATP-binding site [chemical binding]; other site 983545012578 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 983545012579 Sporulation related domain; Region: SPOR; pfam05036 983545012580 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 983545012581 active site 983545012582 HslU subunit interaction site [polypeptide binding]; other site 983545012583 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 983545012584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545012585 Walker A motif; other site 983545012586 ATP binding site [chemical binding]; other site 983545012587 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 983545012588 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 983545012589 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545012590 Beta-lactamase; Region: Beta-lactamase; pfam00144 983545012591 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 983545012592 putative active site [active] 983545012593 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 983545012594 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 983545012595 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545012596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545012597 dimerization interface [polypeptide binding]; other site 983545012598 Bacterial SH3 domain; Region: SH3_3; pfam08239 983545012599 Bacterial SH3 domain; Region: SH3_3; pfam08239 983545012600 Bacterial SH3 domain; Region: SH3_3; pfam08239 983545012601 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 983545012602 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 983545012603 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 983545012604 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 983545012605 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 983545012606 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 983545012607 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 983545012608 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021 983545012609 Protein export membrane protein; Region: SecD_SecF; pfam02355 983545012610 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 983545012611 glutathione reductase; Validated; Region: PRK06116 983545012612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 983545012613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545012614 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545012615 oligopeptidase A; Provisional; Region: PRK10911 983545012616 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545012617 active site 983545012618 Zn binding site [ion binding]; other site 983545012619 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 983545012620 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 983545012621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 983545012622 S-adenosylmethionine binding site [chemical binding]; other site 983545012623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 983545012624 SCP-2 sterol transfer family; Region: SCP2; pfam02036 983545012625 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 983545012626 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 983545012627 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545012628 sec-independent translocase; Provisional; Region: PRK01770 983545012629 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 983545012630 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 983545012631 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545012632 active site 983545012633 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545012634 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545012635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545012636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012637 metal binding site [ion binding]; metal-binding site 983545012638 active site 983545012639 I-site; other site 983545012640 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 983545012641 dimer interface [polypeptide binding]; other site 983545012642 active site 983545012643 aspartate-rich active site metal binding site; other site 983545012644 allosteric magnesium binding site [ion binding]; other site 983545012645 Schiff base residues; other site 983545012646 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 983545012647 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 983545012648 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 983545012649 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 983545012650 ATP binding site [chemical binding]; other site 983545012651 Mg++ binding site [ion binding]; other site 983545012652 motif III; other site 983545012653 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545012654 nucleotide binding region [chemical binding]; other site 983545012655 ATP-binding site [chemical binding]; other site 983545012656 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545012657 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983545012658 catalytic residues [active] 983545012659 transcription termination factor Rho; Provisional; Region: rho; PRK09376 983545012660 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 983545012661 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 983545012662 RNA binding site [nucleotide binding]; other site 983545012663 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 983545012664 multimer interface [polypeptide binding]; other site 983545012665 Walker A motif; other site 983545012666 ATP binding site [chemical binding]; other site 983545012667 Walker B motif; other site 983545012668 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 983545012669 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 983545012670 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 983545012671 ATP-grasp domain; Region: ATP-grasp; pfam02222 983545012672 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 983545012673 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545012674 dimer interface [polypeptide binding]; other site 983545012675 active site 983545012676 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 983545012677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 983545012678 substrate binding site [chemical binding]; other site 983545012679 oxyanion hole (OAH) forming residues; other site 983545012680 trimer interface [polypeptide binding]; other site 983545012681 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 983545012682 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545012683 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545012684 lytic murein transglycosylase; Provisional; Region: PRK11619 983545012685 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 983545012686 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545012687 catalytic residue [active] 983545012688 proline dipeptidase; Provisional; Region: PRK13607 983545012689 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 983545012690 active site 983545012691 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 983545012692 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 983545012693 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 983545012694 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545012695 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 983545012696 putative C-terminal domain interface [polypeptide binding]; other site 983545012697 putative GSH binding site (G-site) [chemical binding]; other site 983545012698 putative dimer interface [polypeptide binding]; other site 983545012699 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 983545012700 N-terminal domain interface [polypeptide binding]; other site 983545012701 dimer interface [polypeptide binding]; other site 983545012702 substrate binding pocket (H-site) [chemical binding]; other site 983545012703 peptidase PmbA; Provisional; Region: PRK11040 983545012704 hypothetical protein; Provisional; Region: PRK05255 983545012705 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 983545012706 protease TldD; Provisional; Region: tldD; PRK10735 983545012707 nitrilase; Region: PLN02798 983545012708 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 983545012709 putative active site [active] 983545012710 catalytic triad [active] 983545012711 dimer interface [polypeptide binding]; other site 983545012712 TIGR02099 family protein; Region: TIGR02099 983545012713 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 983545012714 ribonuclease G; Provisional; Region: PRK11712 983545012715 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 983545012716 homodimer interface [polypeptide binding]; other site 983545012717 oligonucleotide binding site [chemical binding]; other site 983545012718 Maf-like protein; Region: Maf; pfam02545 983545012719 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 983545012720 active site 983545012721 dimer interface [polypeptide binding]; other site 983545012722 rod shape-determining protein MreD; Region: MreD; cl01087 983545012723 rod shape-determining protein MreC; Provisional; Region: PRK13922 983545012724 rod shape-determining protein MreC; Region: MreC; pfam04085 983545012725 rod shape-determining protein MreB; Provisional; Region: PRK13927 983545012726 MreB and similar proteins; Region: MreB_like; cd10225 983545012727 nucleotide binding site [chemical binding]; other site 983545012728 Mg binding site [ion binding]; other site 983545012729 putative protofilament interaction site [polypeptide binding]; other site 983545012730 RodZ interaction site [polypeptide binding]; other site 983545012731 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 983545012732 heterodimerization interface [polypeptide binding]; other site 983545012733 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 983545012734 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 983545012735 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 983545012736 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 983545012737 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545012738 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 983545012739 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 983545012740 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 983545012741 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 983545012742 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545012743 Walker A motif; other site 983545012744 ATP binding site [chemical binding]; other site 983545012745 Walker B motif; other site 983545012746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545012747 binding surface 983545012748 TPR motif; other site 983545012749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 983545012750 TPR motif; other site 983545012751 binding surface 983545012752 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 983545012753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545012754 Walker A motif; other site 983545012755 ATP binding site [chemical binding]; other site 983545012756 Walker B motif; other site 983545012757 arginine finger; other site 983545012758 Secretin and TonB N terminus short domain; Region: STN; pfam07660 983545012759 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 983545012760 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 983545012761 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 983545012762 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 983545012763 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 983545012764 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 983545012765 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 983545012766 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 983545012767 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 983545012768 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 983545012769 inhibitor-cofactor binding pocket; inhibition site 983545012770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545012771 catalytic residue [active] 983545012772 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 983545012773 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 983545012774 putative DNA binding site [nucleotide binding]; other site 983545012775 putative Zn2+ binding site [ion binding]; other site 983545012776 AsnC family; Region: AsnC_trans_reg; pfam01037 983545012777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 983545012778 active site 983545012779 phosphorylation site [posttranslational modification] 983545012780 intermolecular recognition site; other site 983545012781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545012782 active site 983545012783 phosphorylation site [posttranslational modification] 983545012784 intermolecular recognition site; other site 983545012785 dimerization interface [polypeptide binding]; other site 983545012786 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012787 metal binding site [ion binding]; metal-binding site 983545012788 active site 983545012789 I-site; other site 983545012790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545012791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545012792 Methylamine dehydrogenase heavy chain (MADH); Region: Me-amine-dh_H; pfam06433 983545012793 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545012794 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983545012795 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 983545012796 Cytochrome c; Region: Cytochrom_C; cl11414 983545012797 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545012798 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545012799 N-terminal plug; other site 983545012800 ligand-binding site [chemical binding]; other site 983545012801 AMP-binding domain protein; Validated; Region: PRK08315 983545012802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 983545012803 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 983545012804 acyl-activating enzyme (AAE) consensus motif; other site 983545012805 putative AMP binding site [chemical binding]; other site 983545012806 putative active site [active] 983545012807 putative CoA binding site [chemical binding]; other site 983545012808 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545012809 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 983545012810 NAD(P) binding site [chemical binding]; other site 983545012811 catalytic residues [active] 983545012812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545012813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545012814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545012815 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545012816 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545012817 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 983545012818 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 983545012819 dimer interface [polypeptide binding]; other site 983545012820 ssDNA binding site [nucleotide binding]; other site 983545012821 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983545012822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545012824 putative substrate translocation pore; other site 983545012825 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 983545012826 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 983545012827 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 983545012828 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 983545012829 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 983545012830 active site 983545012831 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 983545012832 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 983545012833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545012834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012835 putative substrate translocation pore; other site 983545012836 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 983545012837 dimer interface [polypeptide binding]; other site 983545012838 substrate binding site [chemical binding]; other site 983545012839 metal binding sites [ion binding]; metal-binding site 983545012840 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 983545012841 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 983545012842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 983545012843 motif II; other site 983545012844 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 983545012845 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 983545012846 dimer interface [polypeptide binding]; other site 983545012847 ADP-ribose binding site [chemical binding]; other site 983545012848 active site 983545012849 nudix motif; other site 983545012850 metal binding site [ion binding]; metal-binding site 983545012851 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 983545012852 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 983545012853 active site 983545012854 YceI-like domain; Region: YceI; pfam04264 983545012855 hypothetical protein; Provisional; Region: PRK04966 983545012856 putative hydrolase; Provisional; Region: PRK10985 983545012857 Predicted membrane protein [Function unknown]; Region: COG2855 983545012858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545012859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545012860 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 983545012861 putative dimerization interface [polypeptide binding]; other site 983545012862 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 983545012863 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 983545012864 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 983545012865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 983545012866 Walker A/P-loop; other site 983545012867 ATP binding site [chemical binding]; other site 983545012868 Q-loop/lid; other site 983545012869 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545012870 ABC transporter; Region: ABC_tran_2; pfam12848 983545012871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 983545012872 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 983545012873 SlyX; Region: SlyX; pfam04102 983545012874 FOG: WD40 repeat [General function prediction only]; Region: COG2319 983545012875 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 983545012876 structural tetrad; other site 983545012877 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 983545012878 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 983545012879 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 983545012880 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 983545012881 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 983545012882 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 983545012883 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 983545012884 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 983545012885 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 983545012886 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 983545012887 RNA binding site [nucleotide binding]; other site 983545012888 SprA-related family; Region: SprA-related; pfam12118 983545012889 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 983545012890 comF family protein; Region: comF; TIGR00201 983545012891 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545012892 active site 983545012893 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 983545012894 putative active site [active] 983545012895 Zn binding site [ion binding]; other site 983545012896 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 983545012897 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 983545012898 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 983545012899 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 983545012900 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 983545012901 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 983545012902 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 983545012903 putative active site [active] 983545012904 putative metal binding site [ion binding]; other site 983545012905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545012906 Coenzyme A binding pocket [chemical binding]; other site 983545012907 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 983545012908 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 983545012909 Cu(I) binding site [ion binding]; other site 983545012910 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 983545012911 UbiA prenyltransferase family; Region: UbiA; pfam01040 983545012912 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 983545012913 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 983545012914 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 983545012915 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 983545012916 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 983545012917 Subunit III/VIIa interface [polypeptide binding]; other site 983545012918 Phospholipid binding site [chemical binding]; other site 983545012919 Subunit I/III interface [polypeptide binding]; other site 983545012920 Subunit III/VIb interface [polypeptide binding]; other site 983545012921 Subunit III/VIa interface; other site 983545012922 Subunit III/Vb interface [polypeptide binding]; other site 983545012923 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 983545012924 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545012925 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 983545012926 Subunit I/III interface [polypeptide binding]; other site 983545012927 D-pathway; other site 983545012928 Subunit I/VIIc interface [polypeptide binding]; other site 983545012929 Subunit I/IV interface [polypeptide binding]; other site 983545012930 Subunit I/II interface [polypeptide binding]; other site 983545012931 Low-spin heme (heme a) binding site [chemical binding]; other site 983545012932 Subunit I/VIIa interface [polypeptide binding]; other site 983545012933 Subunit I/VIa interface [polypeptide binding]; other site 983545012934 Dimer interface; other site 983545012935 Putative water exit pathway; other site 983545012936 Binuclear center (heme a3/CuB) [ion binding]; other site 983545012937 K-pathway; other site 983545012938 Subunit I/Vb interface [polypeptide binding]; other site 983545012939 Putative proton exit pathway; other site 983545012940 Subunit I/VIb interface; other site 983545012941 Subunit I/VIc interface [polypeptide binding]; other site 983545012942 Electron transfer pathway; other site 983545012943 Subunit I/VIIIb interface [polypeptide binding]; other site 983545012944 Subunit I/VIIb interface [polypeptide binding]; other site 983545012945 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 983545012946 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 983545012947 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 983545012948 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 983545012949 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 983545012950 LexA repressor; Validated; Region: PRK00215 983545012951 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 983545012952 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 983545012953 Catalytic site [active] 983545012954 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 983545012955 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 983545012956 putative acyl-acceptor binding pocket; other site 983545012957 threonine dehydratase; Reviewed; Region: PRK09224 983545012958 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 983545012959 tetramer interface [polypeptide binding]; other site 983545012960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545012961 catalytic residue [active] 983545012962 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 983545012963 putative Ile/Val binding site [chemical binding]; other site 983545012964 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 983545012965 putative Ile/Val binding site [chemical binding]; other site 983545012966 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 983545012967 Predicted membrane protein [Function unknown]; Region: COG2860 983545012968 UPF0126 domain; Region: UPF0126; pfam03458 983545012969 UPF0126 domain; Region: UPF0126; pfam03458 983545012970 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 983545012971 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 983545012972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 983545012973 Walker A motif; other site 983545012974 ATP binding site [chemical binding]; other site 983545012975 Walker B motif; other site 983545012976 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 983545012977 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545012978 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 983545012979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545012980 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 983545012981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545012982 dimerization interface [polypeptide binding]; other site 983545012983 ketol-acid reductoisomerase; Validated; Region: PRK05225 983545012984 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 983545012985 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 983545012986 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 983545012987 putative outer membrane lipoprotein; Provisional; Region: PRK10510 983545012988 Glycine zipper; Region: Gly-zipper_Omp; cl17724 983545012989 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545012990 ligand binding site [chemical binding]; other site 983545012991 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 983545012992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545012993 putative substrate translocation pore; other site 983545012994 EamA-like transporter family; Region: EamA; pfam00892 983545012995 hypothetical protein; Provisional; Region: PRK08262 983545012996 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 983545012997 metal binding site [ion binding]; metal-binding site 983545012998 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 983545012999 Nidogen-like; Region: NIDO; pfam06119 983545013000 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 983545013001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545013002 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 983545013003 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 983545013004 putative catalytic cysteine [active] 983545013005 gamma-glutamyl kinase; Provisional; Region: PRK05429 983545013006 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 983545013007 nucleotide binding site [chemical binding]; other site 983545013008 homotetrameric interface [polypeptide binding]; other site 983545013009 putative phosphate binding site [ion binding]; other site 983545013010 putative allosteric binding site; other site 983545013011 PUA domain; Region: PUA; pfam01472 983545013012 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 983545013013 Zn binding site [ion binding]; other site 983545013014 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 983545013015 Domain of unknown function DUF20; Region: UPF0118; pfam01594 983545013016 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 983545013017 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 983545013018 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 983545013019 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 983545013020 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983545013021 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 983545013022 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 983545013023 active site 983545013024 Predicted methyltransferase [General function prediction only]; Region: COG4798 983545013025 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 983545013026 CPxP motif; other site 983545013027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 983545013028 active site 983545013029 ribonuclease PH; Reviewed; Region: rph; PRK00173 983545013030 Ribonuclease PH; Region: RNase_PH_bact; cd11362 983545013031 hexamer interface [polypeptide binding]; other site 983545013032 active site 983545013033 hypothetical protein; Provisional; Region: PRK11820 983545013034 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 983545013035 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 983545013036 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 983545013037 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545013038 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983545013039 Sulfate transporter family; Region: Sulfate_transp; pfam00916 983545013040 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545013041 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545013042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545013043 putative substrate translocation pore; other site 983545013044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545013045 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545013046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545013047 putative substrate translocation pore; other site 983545013048 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 983545013049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 983545013050 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 983545013051 dimerization interface [polypeptide binding]; other site 983545013052 substrate binding pocket [chemical binding]; other site 983545013053 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545013054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545013055 short chain dehydrogenase; Provisional; Region: PRK06179 983545013056 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 983545013057 NADP binding site [chemical binding]; other site 983545013058 active site 983545013059 steroid binding site; other site 983545013060 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 983545013061 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 983545013062 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545013063 Zn2+ binding site [ion binding]; other site 983545013064 Mg2+ binding site [ion binding]; other site 983545013065 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545013066 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545013067 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545013068 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545013069 SapC; Region: SapC; pfam07277 983545013070 Cupin-like domain; Region: Cupin_8; pfam13621 983545013071 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 983545013072 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 983545013073 DNA binding site [nucleotide binding] 983545013074 active site 983545013075 DTW domain; Region: DTW; cl01221 983545013076 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545013077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545013078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545013079 dimer interface [polypeptide binding]; other site 983545013080 phosphorylation site [posttranslational modification] 983545013081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545013082 ATP binding site [chemical binding]; other site 983545013083 Mg2+ binding site [ion binding]; other site 983545013084 G-X-G motif; other site 983545013085 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545013086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545013087 active site 983545013088 phosphorylation site [posttranslational modification] 983545013089 intermolecular recognition site; other site 983545013090 dimerization interface [polypeptide binding]; other site 983545013091 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545013092 putative binding surface; other site 983545013093 active site 983545013094 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 983545013095 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 983545013096 gamma subunit interface [polypeptide binding]; other site 983545013097 epsilon subunit interface [polypeptide binding]; other site 983545013098 LBP interface [polypeptide binding]; other site 983545013099 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 983545013100 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 983545013101 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 983545013102 alpha subunit interaction interface [polypeptide binding]; other site 983545013103 Walker A motif; other site 983545013104 ATP binding site [chemical binding]; other site 983545013105 Walker B motif; other site 983545013106 inhibitor binding site; inhibition site 983545013107 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 983545013108 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 983545013109 core domain interface [polypeptide binding]; other site 983545013110 delta subunit interface [polypeptide binding]; other site 983545013111 epsilon subunit interface [polypeptide binding]; other site 983545013112 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 983545013113 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 983545013114 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 983545013115 beta subunit interaction interface [polypeptide binding]; other site 983545013116 Walker A motif; other site 983545013117 ATP binding site [chemical binding]; other site 983545013118 Walker B motif; other site 983545013119 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 983545013120 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 983545013121 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 983545013122 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 983545013123 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 983545013124 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 983545013125 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 983545013126 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 983545013127 ATP synthase I chain; Region: ATP_synt_I; cl09170 983545013128 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 983545013129 ParB-like nuclease domain; Region: ParB; smart00470 983545013130 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 983545013131 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 983545013132 P-loop; other site 983545013133 Magnesium ion binding site [ion binding]; other site 983545013134 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 983545013135 Magnesium ion binding site [ion binding]; other site 983545013136 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 983545013137 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 983545013138 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 983545013139 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 983545013140 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 983545013141 hypothetical protein; Validated; Region: PRK08116 983545013142 primosomal protein DnaI; Provisional; Region: PRK02854 983545013143 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 983545013144 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 983545013145 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 983545013146 trmE is a tRNA modification GTPase; Region: trmE; cd04164 983545013147 G1 box; other site 983545013148 GTP/Mg2+ binding site [chemical binding]; other site 983545013149 Switch I region; other site 983545013150 G2 box; other site 983545013151 Switch II region; other site 983545013152 G3 box; other site 983545013153 G4 box; other site 983545013154 G5 box; other site 983545013155 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 983545013156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 983545013157 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 983545013158 membrane protein insertase; Provisional; Region: PRK01318 983545013159 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 983545013160 Haemolytic domain; Region: Haemolytic; pfam01809 983545013161 ribonuclease P; Reviewed; Region: rnpA; PRK01732 983545013162 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 983545013163 Methyltransferase domain; Region: Methyltransf_26; pfam13659 983545013164 SprT-like family; Region: SprT-like; pfam10263 983545013165 hypothetical protein; Provisional; Region: PRK06850 983545013166 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 983545013167 Ligand Binding Site [chemical binding]; other site 983545013168 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 983545013169 MPN+ (JAMM) motif; other site 983545013170 Zinc-binding site [ion binding]; other site 983545013171 AAA domain; Region: AAA_28; pfam13521 983545013172 Domain of unknown function (DUF4121); Region: DUF4121; pfam13497 983545013173 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 983545013174 cofactor binding site; other site 983545013175 DNA binding site [nucleotide binding] 983545013176 substrate interaction site [chemical binding]; other site 983545013177 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 983545013178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545013179 non-specific DNA binding site [nucleotide binding]; other site 983545013180 salt bridge; other site 983545013181 sequence-specific DNA binding site [nucleotide binding]; other site 983545013182 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 983545013183 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 983545013184 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 983545013185 Ligand Binding Site [chemical binding]; other site 983545013186 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 983545013187 Catalytic site [active] 983545013188 Nucleoid-associated protein [General function prediction only]; Region: COG3081 983545013189 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 983545013190 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983545013191 Interdomain contacts; other site 983545013192 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983545013193 Interdomain contacts; other site 983545013194 Cytokine receptor motif; other site 983545013195 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 983545013196 Family description; Region: VCBS; pfam13517 983545013197 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 983545013198 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 983545013199 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 983545013200 Y-family of DNA polymerases; Region: PolY; cl12025 983545013201 DNA binding site [nucleotide binding] 983545013202 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545013203 DNA binding site [nucleotide binding] 983545013204 active site 983545013205 Int/Topo IB signature motif; other site 983545013206 Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524 983545013207 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 983545013208 Walker A motif; other site 983545013209 ATP binding site [chemical binding]; other site 983545013210 Walker B motif; other site 983545013211 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 983545013212 Mg binding site [ion binding]; other site 983545013213 nucleotide binding site [chemical binding]; other site 983545013214 putative protofilament interface [polypeptide binding]; other site 983545013215 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545013216 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545013217 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 983545013218 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 983545013219 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 983545013220 Methyltransferase domain; Region: Methyltransf_26; pfam13659 983545013221 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 983545013222 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 983545013223 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545013224 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 983545013225 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 983545013226 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 983545013227 AAA-like domain; Region: AAA_10; pfam12846 983545013228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545013229 active site 983545013230 DNA binding site [nucleotide binding] 983545013231 Int/Topo IB signature motif; other site 983545013232 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545013233 active site 2 [active] 983545013234 active site 1 [active] 983545013235 Uncharacterized conserved protein [Function unknown]; Region: COG3791 983545013236 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 983545013237 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 983545013238 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 983545013239 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545013240 active site 983545013241 DNA binding site [nucleotide binding] 983545013242 Int/Topo IB signature motif; other site 983545013243 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 983545013244 Putative transposase; Region: Y2_Tnp; pfam04986 983545013245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 983545013246 Aspartyl protease; Region: Asp_protease_2; pfam13650 983545013247 inhibitor binding site; inhibition site 983545013248 catalytic motif [active] 983545013249 Catalytic residue [active] 983545013250 Active site flap [active] 983545013251 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 983545013252 IHF dimer interface [polypeptide binding]; other site 983545013253 IHF - DNA interface [nucleotide binding]; other site 983545013254 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 983545013255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545013256 putative active site [active] 983545013257 heme pocket [chemical binding]; other site 983545013258 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545013259 metal binding site [ion binding]; metal-binding site 983545013260 active site 983545013261 I-site; other site 983545013262 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545013263 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545013264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545013265 NAD(P) binding site [chemical binding]; other site 983545013266 active site 983545013267 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 983545013268 putative active site [active] 983545013269 redox center [active] 983545013270 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 983545013271 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 983545013272 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 983545013273 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545013274 DNA binding residues [nucleotide binding] 983545013275 putative mercuric reductase; Provisional; Region: PRK13748 983545013276 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545013277 metal-binding site [ion binding] 983545013278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 983545013279 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545013280 putative mercury transport protein MerC; Provisional; Region: PRK13755 983545013281 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545013282 metal-binding site [ion binding] 983545013283 MerT mercuric transport protein; Region: MerT; cl03578 983545013284 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 983545013285 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 983545013286 DNA binding residues [nucleotide binding] 983545013287 dimer interface [polypeptide binding]; other site 983545013288 mercury binding site [ion binding]; other site 983545013289 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 983545013290 DNA binding site [nucleotide binding] 983545013291 dimer interface [polypeptide binding]; other site 983545013292 active site 983545013293 Int/Topo IB signature motif; other site 983545013294 hypothetical protein; Provisional; Region: PRK02237 983545013295 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545013296 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545013297 active site 983545013298 dimer interface [polypeptide binding]; other site 983545013299 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 983545013300 Ligand Binding Site [chemical binding]; other site 983545013301 Molecular Tunnel; other site 983545013302 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 983545013303 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545013304 carboxyltransferase (CT) interaction site; other site 983545013305 biotinylation site [posttranslational modification]; other site 983545013306 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545013307 Outer membrane efflux protein; Region: OEP; pfam02321 983545013308 Outer membrane efflux protein; Region: OEP; pfam02321 983545013309 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 983545013310 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 983545013311 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545013312 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 983545013313 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545013314 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545013315 DNA binding residues [nucleotide binding] 983545013316 dimer interface [polypeptide binding]; other site 983545013317 putative metal binding site [ion binding]; other site 983545013318 hypothetical protein; Provisional; Region: PRK09272 983545013319 Penicillinase repressor; Region: Pencillinase_R; cl17580 983545013320 Peptidase family M48; Region: Peptidase_M48; cl12018 983545013321 Outer membrane efflux protein; Region: OEP; pfam02321 983545013322 Outer membrane efflux protein; Region: OEP; pfam02321 983545013323 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 983545013324 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545013325 E3 interaction surface; other site 983545013326 lipoyl attachment site [posttranslational modification]; other site 983545013327 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545013328 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 983545013329 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 983545013330 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545013331 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545013332 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 983545013333 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545013334 DNA binding site [nucleotide binding] 983545013335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545013336 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545013337 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 983545013338 structural tetrad; other site 983545013339 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 983545013340 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 983545013341 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 983545013342 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545013343 catalytic loop [active] 983545013344 iron binding site [ion binding]; other site 983545013345 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 983545013346 FAD binding pocket [chemical binding]; other site 983545013347 FAD binding motif [chemical binding]; other site 983545013348 phosphate binding motif [ion binding]; other site 983545013349 beta-alpha-beta structure motif; other site 983545013350 NAD binding pocket [chemical binding]; other site 983545013351 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 983545013352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545013353 active site 983545013354 phosphorylation site [posttranslational modification] 983545013355 intermolecular recognition site; other site 983545013356 dimerization interface [polypeptide binding]; other site 983545013357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545013358 DNA binding site [nucleotide binding] 983545013359 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 983545013360 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 983545013361 Multicopper oxidase; Region: Cu-oxidase; pfam00394 983545013362 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 983545013363 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 983545013364 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 983545013365 CopC domain; Region: CopC; pfam04234 983545013366 Copper resistance protein D; Region: CopD; cl00563 983545013367 SnoaL-like domain; Region: SnoaL_3; pfam13474 983545013368 SnoaL-like domain; Region: SnoaL_2; pfam12680 983545013369 Domain of unknown function (DUF305); Region: DUF305; cl17794 983545013370 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 983545013371 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 983545013372 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 983545013373 carboxyltransferase (CT) interaction site; other site 983545013374 biotinylation site [posttranslational modification]; other site 983545013375 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545013376 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 983545013377 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 983545013378 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 983545013379 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545013380 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 983545013381 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545013382 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545013383 DNA binding residues [nucleotide binding] 983545013384 dimer interface [polypeptide binding]; other site 983545013385 putative metal binding site [ion binding]; other site 983545013386 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 983545013387 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 983545013388 Ligand binding site; other site 983545013389 Putative Catalytic site; other site 983545013390 DXD motif; other site 983545013391 Uncharacterized conserved protein [Function unknown]; Region: COG0398 983545013392 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 983545013393 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 983545013394 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 983545013395 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 983545013396 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 983545013397 active site residue [active] 983545013398 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545013399 active site residue [active] 983545013400 Sulphur transport; Region: Sulf_transp; pfam04143 983545013401 Predicted transporter component [General function prediction only]; Region: COG2391 983545013402 sensor protein QseC; Provisional; Region: PRK10337 983545013403 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 983545013404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545013405 dimer interface [polypeptide binding]; other site 983545013406 phosphorylation site [posttranslational modification] 983545013407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545013408 ATP binding site [chemical binding]; other site 983545013409 Mg2+ binding site [ion binding]; other site 983545013410 G-X-G motif; other site 983545013411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545013412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545013413 active site 983545013414 phosphorylation site [posttranslational modification] 983545013415 intermolecular recognition site; other site 983545013416 dimerization interface [polypeptide binding]; other site 983545013417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545013418 DNA binding site [nucleotide binding] 983545013419 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 983545013420 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 983545013421 catalytic residues [active] 983545013422 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 983545013423 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 983545013424 dimerization domain [polypeptide binding]; other site 983545013425 dimer interface [polypeptide binding]; other site 983545013426 catalytic residues [active] 983545013427 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545013428 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 983545013429 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545013430 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545013431 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 983545013432 Putative phosphatase (DUF442); Region: DUF442; cl17385 983545013433 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 983545013434 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 983545013435 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 983545013436 Multicopper oxidase; Region: Cu-oxidase; pfam00394 983545013437 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 983545013438 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 983545013439 Domain of unknown function (DUF305); Region: DUF305; cl17794 983545013440 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 983545013441 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 983545013442 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 983545013443 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 983545013444 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983545013445 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545013446 metal-binding site [ion binding] 983545013447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983545013448 Soluble P-type ATPase [General function prediction only]; Region: COG4087 983545013449 Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787 983545013450 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 983545013451 DNA binding residues [nucleotide binding] 983545013452 dimer interface [polypeptide binding]; other site 983545013453 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 983545013454 dimerization interface [polypeptide binding]; other site 983545013455 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 983545013456 ATP binding site [chemical binding]; other site 983545013457 Acylphosphatase; Region: Acylphosphatase; pfam00708 983545013458 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 983545013459 HypF finger; Region: zf-HYPF; pfam07503 983545013460 HypF finger; Region: zf-HYPF; pfam07503 983545013461 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 983545013462 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 983545013463 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 983545013464 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 983545013465 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 983545013466 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 983545013467 HupF/HypC family; Region: HupF_HypC; pfam01455 983545013468 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 983545013469 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 983545013470 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 983545013471 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 983545013472 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 983545013473 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 983545013474 putative substrate-binding site; other site 983545013475 nickel binding site [ion binding]; other site 983545013476 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 983545013477 heme-binding residues [chemical binding]; other site 983545013478 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 983545013479 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 983545013480 FAD binding pocket [chemical binding]; other site 983545013481 FAD binding motif [chemical binding]; other site 983545013482 phosphate binding motif [ion binding]; other site 983545013483 beta-alpha-beta structure motif; other site 983545013484 NAD binding pocket [chemical binding]; other site 983545013485 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545013486 catalytic loop [active] 983545013487 iron binding site [ion binding]; other site 983545013488 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 983545013489 Cytochrome c; Region: Cytochrom_C; pfam00034 983545013490 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983545013491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545013492 NAD(P) binding site [chemical binding]; other site 983545013493 active site 983545013494 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545013495 FAD binding domain; Region: FAD_binding_4; pfam01565 983545013496 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 983545013497 SnoaL-like domain; Region: SnoaL_3; pfam13474 983545013498 Copper resistance protein D; Region: CopD; pfam05425 983545013499 CopC domain; Region: CopC; pfam04234 983545013500 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 983545013501 FAD binding pocket [chemical binding]; other site 983545013502 conserved FAD binding motif [chemical binding]; other site 983545013503 phosphate binding motif [ion binding]; other site 983545013504 beta-alpha-beta structure motif; other site 983545013505 NAD binding pocket [chemical binding]; other site 983545013506 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 983545013507 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983545013508 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 983545013509 HlyD family secretion protein; Region: HlyD_3; pfam13437 983545013510 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 983545013511 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 983545013512 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 983545013513 Outer membrane efflux protein; Region: OEP; pfam02321 983545013514 Outer membrane efflux protein; Region: OEP; pfam02321 983545013515 Protein of unknown function, DUF; Region: DUF411; cl01142 983545013516 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 983545013517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545013518 active site 983545013519 phosphorylation site [posttranslational modification] 983545013520 intermolecular recognition site; other site 983545013521 dimerization interface [polypeptide binding]; other site 983545013522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545013523 DNA binding site [nucleotide binding] 983545013524 sensor kinase CusS; Provisional; Region: PRK09835 983545013525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 983545013526 dimerization interface [polypeptide binding]; other site 983545013527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545013528 dimer interface [polypeptide binding]; other site 983545013529 phosphorylation site [posttranslational modification] 983545013530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545013531 ATP binding site [chemical binding]; other site 983545013532 Mg2+ binding site [ion binding]; other site 983545013533 G-X-G motif; other site 983545013534 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545013535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 983545013536 active site 983545013537 phosphorylation site [posttranslational modification] 983545013538 intermolecular recognition site; other site 983545013539 dimerization interface [polypeptide binding]; other site 983545013540 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 983545013541 DNA binding site [nucleotide binding] 983545013542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545013543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 983545013544 dimer interface [polypeptide binding]; other site 983545013545 phosphorylation site [posttranslational modification] 983545013546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545013547 ATP binding site [chemical binding]; other site 983545013548 Mg2+ binding site [ion binding]; other site 983545013549 G-X-G motif; other site 983545013550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 983545013551 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 983545013552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 983545013553 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 983545013554 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 983545013555 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 983545013556 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 983545013557 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 983545013558 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 983545013559 active site 983545013560 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 983545013561 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 983545013562 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545013563 Sulfatase; Region: Sulfatase; pfam00884 983545013564 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 983545013565 Surface antigen; Region: Bac_surface_Ag; pfam01103 983545013566 putative metal dependent hydrolase; Provisional; Region: PRK11598 983545013567 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545013568 Sulfatase; Region: Sulfatase; pfam00884 983545013569 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 983545013570 Transposase; Region: HTH_Tnp_1; pfam01527 983545013571 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 983545013572 Sulfatase; Region: Sulfatase; pfam00884 983545013573 putative transposase OrfB; Reviewed; Region: PHA02517 983545013574 HTH-like domain; Region: HTH_21; pfam13276 983545013575 Integrase core domain; Region: rve; pfam00665 983545013576 Integrase core domain; Region: rve_3; pfam13683 983545013577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 983545013578 Transposase; Region: HTH_Tnp_1; pfam01527 983545013579 non-specific DNA binding site [nucleotide binding]; other site 983545013580 salt bridge; other site 983545013581 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 983545013582 sequence-specific DNA binding site [nucleotide binding]; other site 983545013583 HipA N-terminal domain; Region: Couple_hipA; cl11853 983545013584 HipA-like N-terminal domain; Region: HipA_N; pfam07805 983545013585 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545013586 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 983545013587 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 983545013588 Part of AAA domain; Region: AAA_19; pfam13245 983545013589 Family description; Region: UvrD_C_2; pfam13538 983545013590 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 983545013591 Calx-beta domain; Region: Calx-beta; cl02522 983545013592 Calx-beta domain; Region: Calx-beta; cl02522 983545013593 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 983545013594 Calx-beta domain; Region: Calx-beta; cl02522 983545013595 Calx-beta domain; Region: Calx-beta; cl02522 983545013596 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 983545013597 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 983545013598 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 983545013599 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 983545013600 Protein of unknown function (DUF993); Region: DUF993; pfam06187 983545013601 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545013602 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 983545013603 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 983545013604 Walker A motif; other site 983545013605 ATP binding site [chemical binding]; other site 983545013606 Walker B motif; other site 983545013607 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 983545013608 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 983545013609 Putative exonuclease, RdgC; Region: RdgC; cl01122 983545013610 Staphylococcal nuclease homologues; Region: SNc; smart00318 983545013611 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 983545013612 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 983545013613 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 983545013614 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545013615 metal binding site [ion binding]; metal-binding site 983545013616 active site 983545013617 I-site; other site 983545013618 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545013619 probable DNA repair protein; Region: TIGR03623 983545013620 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 983545013621 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 983545013622 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 983545013623 Family description; Region: UvrD_C_2; pfam13538 983545013624 plasmid-partitioning protein; Provisional; Region: PRK13698 983545013625 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 983545013626 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 983545013627 P-loop; other site 983545013628 Magnesium ion binding site [ion binding]; other site 983545013629 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 983545013630 ParB-like nuclease domain; Region: ParB; smart00470 983545013631 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545013632 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 983545013633 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 983545013634 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 983545013635 ATP binding site [chemical binding]; other site 983545013636 substrate interface [chemical binding]; other site