-- dump date 20111121_012341 -- class Genbank::misc_feature -- table misc_feature_note -- id note 983545000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 983545000002 hypothetical protein; Validated; Region: PRK06672 983545000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545000004 Walker A motif; other site 983545000005 ATP binding site [chemical binding]; other site 983545000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545000007 Walker B motif; other site 983545000008 arginine finger; other site 983545000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 983545000010 DnaA box-binding interface [nucleotide binding]; other site 983545000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 983545000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 983545000013 putative DNA binding surface [nucleotide binding]; other site 983545000014 dimer interface [polypeptide binding]; other site 983545000015 beta-clamp/clamp loader binding surface; other site 983545000016 beta-clamp/translesion DNA polymerase binding surface; other site 983545000017 recombination protein F; Reviewed; Region: recF; PRK00064 983545000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545000019 Walker A/P-loop; other site 983545000020 ATP binding site [chemical binding]; other site 983545000021 Q-loop/lid; other site 983545000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545000023 ABC transporter signature motif; other site 983545000024 Walker B; other site 983545000025 D-loop; other site 983545000026 H-loop/switch region; other site 983545000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 983545000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 983545000030 anchoring element; other site 983545000031 dimer interface [polypeptide binding]; other site 983545000032 ATP binding site [chemical binding]; other site 983545000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 983545000034 active site 983545000035 putative metal-binding site [ion binding]; other site 983545000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 983545000037 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 983545000038 aspartate racemase; Region: asp_race; TIGR00035 983545000039 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545000040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000041 metal binding site [ion binding]; metal-binding site 983545000042 active site 983545000043 I-site; other site 983545000044 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 983545000045 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 983545000046 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 983545000047 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 983545000048 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 983545000049 dimer interface [polypeptide binding]; other site 983545000050 motif 1; other site 983545000051 active site 983545000052 motif 2; other site 983545000053 motif 3; other site 983545000054 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 983545000055 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 983545000056 Protein of unknown function, DUF414; Region: DUF414; cl01172 983545000057 Cytochrome c; Region: Cytochrom_C; cl11414 983545000058 Cytochrome c; Region: Cytochrom_C; cl11414 983545000059 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 983545000060 G1 box; other site 983545000061 GTP/Mg2+ binding site [chemical binding]; other site 983545000062 Switch I region; other site 983545000063 G2 box; other site 983545000064 G3 box; other site 983545000065 Switch II region; other site 983545000066 G4 box; other site 983545000067 G5 box; other site 983545000068 DNA polymerase I; Provisional; Region: PRK05755 983545000069 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 983545000070 active site 983545000071 metal binding site 1 [ion binding]; metal-binding site 983545000072 putative 5' ssDNA interaction site; other site 983545000073 metal binding site 3; metal-binding site 983545000074 metal binding site 2 [ion binding]; metal-binding site 983545000075 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 983545000076 putative DNA binding site [nucleotide binding]; other site 983545000077 putative metal binding site [ion binding]; other site 983545000078 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 983545000079 active site 983545000080 catalytic site [active] 983545000081 substrate binding site [chemical binding]; other site 983545000082 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 983545000083 active site 983545000084 DNA binding site [nucleotide binding] 983545000085 catalytic site [active] 983545000086 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 983545000087 Cation transport protein; Region: TrkH; cl10514 983545000088 Enterobacterial TraT complement resistance protein; Region: TraT; cl05410 983545000089 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 983545000090 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 983545000091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000092 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545000093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000094 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545000095 16S rRNA methyltransferase B; Provisional; Region: PRK10901 983545000096 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 983545000097 putative RNA binding site [nucleotide binding]; other site 983545000098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545000099 S-adenosylmethionine binding site [chemical binding]; other site 983545000100 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 983545000101 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 983545000102 putative active site [active] 983545000103 substrate binding site [chemical binding]; other site 983545000104 putative cosubstrate binding site; other site 983545000105 catalytic site [active] 983545000106 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 983545000107 substrate binding site [chemical binding]; other site 983545000108 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 983545000109 active site 983545000110 catalytic residues [active] 983545000111 metal binding site [ion binding]; metal-binding site 983545000112 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545000113 putative peptidoglycan binding site; other site 983545000114 hypothetical protein; Provisional; Region: PRK10736 983545000115 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 983545000116 Protein of unknown function (DUF494); Region: DUF494; cl01103 983545000117 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 983545000118 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 983545000119 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 983545000120 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 983545000121 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 983545000122 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 983545000123 Surface antigen; Region: Surface_Ag_2; cl01155 983545000124 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 983545000125 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 983545000126 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 983545000127 shikimate binding site; other site 983545000128 NAD(P) binding site [chemical binding]; other site 983545000129 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 983545000130 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 983545000131 trimer interface [polypeptide binding]; other site 983545000132 putative metal binding site [ion binding]; other site 983545000133 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 983545000134 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 983545000135 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 983545000136 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 983545000137 generic binding surface II; other site 983545000138 generic binding surface I; other site 983545000139 DNA Polymerase Y-family; Region: PolY_like; cd03468 983545000140 active site 983545000141 DNA binding site [nucleotide binding] 983545000142 Cell division inhibitor SulA; Region: SulA; cl01880 983545000143 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 983545000144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545000145 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000146 metal binding site [ion binding]; metal-binding site 983545000147 active site 983545000148 I-site; other site 983545000149 Protein of unknown function (DUF2012); Region: DUF2012; pfam09430 983545000150 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545000151 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545000152 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545000153 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 983545000154 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545000155 active site 983545000156 metal binding site [ion binding]; metal-binding site 983545000157 Phytase; Region: Phytase; pfam02333 983545000158 Phytase; Region: Phytase; pfam02333 983545000159 EVE domain; Region: EVE; cl00728 983545000160 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545000161 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 983545000162 M28, and M42; Region: Zinc_peptidase_like; cl14876 983545000163 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_1; cd04820 983545000164 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545000165 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 983545000166 metal binding site [ion binding]; metal-binding site 983545000167 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545000168 division inhibitor protein; Provisional; Region: slmA; PRK09480 983545000169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545000170 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 983545000171 Flavoprotein; Region: Flavoprotein; cl08021 983545000172 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 983545000173 hypothetical protein; Reviewed; Region: PRK00024 983545000174 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 983545000175 MPN+ (JAMM) motif; other site 983545000176 Zinc-binding site [ion binding]; other site 983545000177 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 983545000178 Substrate binding site [chemical binding]; other site 983545000179 metal binding site [ion binding]; metal-binding site 983545000180 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 983545000181 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 983545000182 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 983545000183 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 983545000184 DNA binding site [nucleotide binding] 983545000185 catalytic residue [active] 983545000186 H2TH interface [polypeptide binding]; other site 983545000187 putative catalytic residues [active] 983545000188 turnover-facilitating residue; other site 983545000189 intercalation triad [nucleotide binding]; other site 983545000190 8OG recognition residue [nucleotide binding]; other site 983545000191 putative reading head residues; other site 983545000192 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 983545000193 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 983545000194 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 983545000195 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 983545000196 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 983545000197 active site 983545000198 (T/H)XGH motif; other site 983545000199 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545000200 ATP binding site [chemical binding]; other site 983545000201 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545000202 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 983545000203 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 983545000204 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 983545000205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000206 metal binding site [ion binding]; metal-binding site 983545000207 active site 983545000208 I-site; other site 983545000209 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000210 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 983545000211 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 983545000212 substrate-cofactor binding pocket; other site 983545000213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000214 catalytic residue [active] 983545000215 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 983545000216 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 983545000217 NAD(P) binding site [chemical binding]; other site 983545000218 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 983545000219 active site residue [active] 983545000220 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 983545000221 intramembrane serine protease GlpG; Provisional; Region: PRK10907 983545000222 Rhomboid family; Region: Rhomboid; cl11446 983545000223 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 983545000224 Chorismate lyase; Region: Chor_lyase; cl01230 983545000225 UbiA prenyltransferase family; Region: UbiA; cl00337 983545000226 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 983545000227 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545000228 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545000229 Membrane fusogenic activity; Region: BMFP; cl01115 983545000230 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 983545000231 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545000232 GAF domain; Region: GAF; cl00853 983545000233 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545000234 GAF domain; Region: GAF; cl00853 983545000235 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000236 metal binding site [ion binding]; metal-binding site 983545000237 active site 983545000238 I-site; other site 983545000239 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000240 Cytochrome c; Region: Cytochrom_C; cl11414 983545000241 DNA ligase; Provisional; Region: PRK09125 983545000242 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 983545000243 DNA binding site [nucleotide binding] 983545000244 active site 983545000245 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 983545000246 DNA binding site [nucleotide binding] 983545000247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545000249 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 983545000250 adenine DNA glycosylase; Provisional; Region: PRK10880 983545000251 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 983545000252 minor groove reading motif; other site 983545000253 helix-hairpin-helix signature motif; other site 983545000254 substrate binding pocket [chemical binding]; other site 983545000255 active site 983545000256 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 983545000257 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 983545000258 DNA binding and oxoG recognition site [nucleotide binding] 983545000259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545000260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545000261 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 983545000262 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 983545000263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545000264 glycogen synthase; Provisional; Region: glgA; PRK00654 983545000265 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 983545000266 ADP-binding pocket [chemical binding]; other site 983545000267 homodimer interface [polypeptide binding]; other site 983545000268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 983545000269 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545000270 sensor protein ZraS; Provisional; Region: PRK10364 983545000271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545000272 dimer interface [polypeptide binding]; other site 983545000273 phosphorylation site [posttranslational modification] 983545000274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000275 ATP binding site [chemical binding]; other site 983545000276 G-X-G motif; other site 983545000277 two-component response regulator; Provisional; Region: PRK11173 983545000278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545000279 active site 983545000280 phosphorylation site [posttranslational modification] 983545000281 intermolecular recognition site; other site 983545000282 dimerization interface [polypeptide binding]; other site 983545000283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545000284 DNA binding site [nucleotide binding] 983545000285 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 983545000286 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 983545000287 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 983545000288 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 983545000289 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 983545000290 DsbD alpha interface [polypeptide binding]; other site 983545000291 catalytic residues [active] 983545000292 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000293 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545000294 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 983545000295 Protein of unknown function, DUF479; Region: DUF479; cl01203 983545000296 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 983545000297 trimer interface [polypeptide binding]; other site 983545000298 active site 983545000299 dimer interface [polypeptide binding]; other site 983545000300 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 983545000301 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 983545000302 carboxyltransferase (CT) interaction site; other site 983545000303 biotinylation site [posttranslational modification]; other site 983545000304 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 983545000305 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545000306 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545000307 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 983545000308 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 983545000309 MatE; Region: MatE; pfam01554 983545000310 MatE; Region: MatE; pfam01554 983545000311 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 983545000312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545000313 S-adenosylmethionine binding site [chemical binding]; other site 983545000314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545000315 PEP-CTERM putative exosortase interaction domain; Region: PEP_exosort; TIGR02595 983545000316 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 983545000317 active site 983545000318 catalytic residues [active] 983545000319 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 983545000320 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 983545000321 active site 983545000322 catalytic residues [active] 983545000323 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 983545000324 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 983545000325 active site 983545000326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545000327 OsmC-like protein; Region: OsmC; cl00767 983545000328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545000329 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 983545000330 Walker A motif; other site 983545000331 ATP binding site [chemical binding]; other site 983545000332 Walker B motif; other site 983545000333 arginine finger; other site 983545000334 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 983545000335 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545000336 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545000337 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545000338 conserved cys residue [active] 983545000339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545000340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545000341 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 983545000342 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545000343 active site 983545000344 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 983545000345 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545000346 active site 983545000347 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545000348 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545000349 N-terminal plug; other site 983545000350 ligand-binding site [chemical binding]; other site 983545000351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545000352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545000353 putative substrate translocation pore; other site 983545000354 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545000355 dimerization interface [polypeptide binding]; other site 983545000356 putative DNA binding site [nucleotide binding]; other site 983545000357 putative Zn2+ binding site [ion binding]; other site 983545000358 Predicted permease; Region: DUF318; cl00487 983545000359 hypothetical protein; Provisional; Region: PRK09897 983545000360 Dienelactone hydrolase family; Region: DLH; pfam01738 983545000361 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000362 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 983545000363 putative active site [active] 983545000364 putative cosubstrate binding site; other site 983545000365 putative substrate binding site [chemical binding]; other site 983545000366 catalytic site [active] 983545000367 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 983545000368 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 983545000369 active site 983545000370 nucleophile elbow; other site 983545000371 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545000372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545000373 catalytic residue [active] 983545000374 Uncharacterized conserved protein [Function unknown]; Region: COG1284 983545000375 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 983545000376 putative metal binding site [ion binding]; other site 983545000377 adenylosuccinate synthetase; Provisional; Region: PRK01117 983545000378 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 983545000379 GDP-binding site [chemical binding]; other site 983545000380 ACT binding site; other site 983545000381 IMP binding site; other site 983545000382 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 983545000383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545000384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545000385 dimer interface [polypeptide binding]; other site 983545000386 phosphorylation site [posttranslational modification] 983545000387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000388 ATP binding site [chemical binding]; other site 983545000389 Mg2+ binding site [ion binding]; other site 983545000390 G-X-G motif; other site 983545000391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545000392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545000393 active site 983545000394 phosphorylation site [posttranslational modification] 983545000395 intermolecular recognition site; other site 983545000396 dimerization interface [polypeptide binding]; other site 983545000397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545000398 DNA binding site [nucleotide binding] 983545000399 Spondin_N; Region: Spond_N; pfam06468 983545000400 Spondin_N; Region: Spond_N; pfam06468 983545000401 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 983545000402 M28, and M42; Region: Zinc_peptidase_like; cd03873 983545000403 M28, and M42; Region: Zinc_peptidase_like; cd03873 983545000404 metal binding site [ion binding]; metal-binding site 983545000405 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545000406 osmolarity response regulator; Provisional; Region: ompR; PRK09468 983545000407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545000408 active site 983545000409 phosphorylation site [posttranslational modification] 983545000410 intermolecular recognition site; other site 983545000411 dimerization interface [polypeptide binding]; other site 983545000412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545000413 DNA binding site [nucleotide binding] 983545000414 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 983545000415 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545000416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545000417 dimer interface [polypeptide binding]; other site 983545000418 phosphorylation site [posttranslational modification] 983545000419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000420 ATP binding site [chemical binding]; other site 983545000421 Mg2+ binding site [ion binding]; other site 983545000422 G-X-G motif; other site 983545000423 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 983545000424 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 983545000425 dimerization interface [polypeptide binding]; other site 983545000426 domain crossover interface; other site 983545000427 redox-dependent activation switch; other site 983545000428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545000429 RNA binding surface [nucleotide binding]; other site 983545000430 short chain dehydrogenase; Provisional; Region: PRK06123 983545000431 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545000432 NADP binding site [chemical binding]; other site 983545000433 homodimer interface [polypeptide binding]; other site 983545000434 active site 983545000435 general secretion pathway protein C; Region: typeII_sec_gspC; TIGR01713 983545000436 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 983545000437 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 983545000438 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000439 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000440 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545000441 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 983545000442 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 983545000443 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545000444 Walker A motif; other site 983545000445 ATP binding site [chemical binding]; other site 983545000446 Walker B motif; other site 983545000447 general secretion pathway protein F; Region: GspF; TIGR02120 983545000448 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 983545000449 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 983545000450 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 983545000451 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 983545000452 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 983545000453 general secretion pathway protein H; Region: typeII_sec_gspH; TIGR01708 983545000454 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 983545000455 general secretion pathway protein I; Region: gspI; TIGR01707 983545000456 Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501 983545000457 general secretion pathway protein J; Region: gspJ; TIGR01711 983545000458 Pseudopilin GspJ; Region: GspJ; pfam11612 983545000459 General secretion pathway protein K; Region: GspK; pfam03934 983545000460 general secretion pathway protein L; Region: typeII_sec_gspL; TIGR01709 983545000461 GspL cytoplasmic actin-ATPase-like region; Region: GspL; pfam05134 983545000462 GspL periplasmic domain; Region: GspL_C; cl14909 983545000463 General secretion pathway, M protein; Region: GspM; cl01222 983545000464 Bacterial type II secretion system protein N; Region: GSPII_N; pfam01203 983545000465 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 983545000466 AMP binding site [chemical binding]; other site 983545000467 metal binding site [ion binding]; metal-binding site 983545000468 active site 983545000469 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 983545000470 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545000471 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545000472 S1/P1 Nuclease; Region: S1-P1_nuclease; pfam02265 983545000473 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 983545000474 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 983545000475 substrate binding site [chemical binding]; other site 983545000476 active site 983545000477 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 983545000478 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 983545000479 putative NADH binding site [chemical binding]; other site 983545000480 putative active site [active] 983545000481 nudix motif; other site 983545000482 putative metal binding site [ion binding]; other site 983545000483 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 983545000484 metal binding site 2 [ion binding]; metal-binding site 983545000485 putative DNA binding helix; other site 983545000486 metal binding site 1 [ion binding]; metal-binding site 983545000487 dimer interface [polypeptide binding]; other site 983545000488 structural Zn2+ binding site [ion binding]; other site 983545000489 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 983545000490 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 983545000491 OprF membrane domain; Region: OprF; pfam05736 983545000492 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545000493 ligand binding site [chemical binding]; other site 983545000494 replicative DNA helicase; Region: DnaB; TIGR00665 983545000495 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 983545000496 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 983545000497 Walker A motif; other site 983545000498 ATP binding site [chemical binding]; other site 983545000499 Walker B motif; other site 983545000500 DNA binding loops [nucleotide binding] 983545000501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 983545000502 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 983545000503 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545000504 ATP binding site [chemical binding]; other site 983545000505 ATP binding site [chemical binding]; other site 983545000506 putative Mg++ binding site [ion binding]; other site 983545000507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545000508 nucleotide binding region [chemical binding]; other site 983545000509 ATP-binding site [chemical binding]; other site 983545000510 RQC domain; Region: RQC; pfam09382 983545000511 HRDC domain; Region: HRDC; cl02578 983545000512 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545000513 CoenzymeA binding site [chemical binding]; other site 983545000514 subunit interaction site [polypeptide binding]; other site 983545000515 PHB binding site; other site 983545000516 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 983545000517 apolar tunnel; other site 983545000518 heme binding site [chemical binding]; other site 983545000519 dimerization interface [polypeptide binding]; other site 983545000520 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 983545000521 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545000522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000523 metal binding site [ion binding]; metal-binding site 983545000524 active site 983545000525 I-site; other site 983545000526 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000527 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000528 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000529 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 983545000530 Surface antigen; Region: Bac_surface_Ag; cl03097 983545000531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 983545000532 Family of unknown function (DUF490); Region: DUF490; pfam04357 983545000533 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 983545000534 MgtE intracellular N domain; Region: MgtE_N; cl15244 983545000535 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 983545000536 Divalent cation transporter; Region: MgtE; cl00786 983545000537 BON domain; Region: BON; cl02771 983545000538 BON domain; Region: BON; cl02771 983545000539 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545000541 active site 983545000542 phosphorylation site [posttranslational modification] 983545000543 intermolecular recognition site; other site 983545000544 dimerization interface [polypeptide binding]; other site 983545000545 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000546 metal binding site [ion binding]; metal-binding site 983545000547 active site 983545000548 I-site; other site 983545000549 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 983545000550 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 983545000551 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545000552 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 983545000553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545000554 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 983545000555 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 983545000556 purine monophosphate binding site [chemical binding]; other site 983545000557 dimer interface [polypeptide binding]; other site 983545000558 putative catalytic residues [active] 983545000559 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 983545000560 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 983545000561 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 983545000562 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 983545000563 FMN binding site [chemical binding]; other site 983545000564 active site 983545000565 catalytic residues [active] 983545000566 substrate binding site [chemical binding]; other site 983545000567 Protein of unknown function (DUF962); Region: DUF962; cl01879 983545000568 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 983545000569 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 983545000570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545000571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545000572 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545000573 putative effector binding pocket; other site 983545000574 dimerization interface [polypeptide binding]; other site 983545000575 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545000576 putative catalytic residues [active] 983545000577 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 983545000578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545000579 motif II; other site 983545000580 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000581 substrate binding pocket [chemical binding]; other site 983545000582 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 983545000583 Predicted deacylase [General function prediction only]; Region: COG3608 983545000584 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_4; cd06254 983545000585 putative active site [active] 983545000586 Zn-binding site [ion binding]; other site 983545000587 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545000588 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 983545000589 Conserved TM helix; Region: TM_helix; pfam05552 983545000590 mechanosensitive channel MscS; Provisional; Region: PRK10334 983545000591 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000592 hypothetical protein; Provisional; Region: PRK12361 983545000593 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 983545000594 active site 983545000595 catalytic residues [active] 983545000596 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 983545000597 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545000598 putative catalytic residues [active] 983545000599 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 983545000600 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 983545000601 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545000602 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 983545000603 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545000604 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545000606 active site 983545000607 phosphorylation site [posttranslational modification] 983545000608 intermolecular recognition site; other site 983545000609 dimerization interface [polypeptide binding]; other site 983545000610 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000611 metal binding site [ion binding]; metal-binding site 983545000612 active site 983545000613 I-site; other site 983545000614 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 983545000615 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545000616 serine acetyltransferase; Provisional; Region: cysE; PRK11132 983545000617 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 983545000618 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 983545000619 trimer interface [polypeptide binding]; other site 983545000620 active site 983545000621 substrate binding site [chemical binding]; other site 983545000622 CoA binding site [chemical binding]; other site 983545000623 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 983545000624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545000625 motif II; other site 983545000626 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 983545000627 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545000628 DNA binding site [nucleotide binding] 983545000629 Int/Topo IB signature motif; other site 983545000630 active site 983545000631 Protein of unknown function, DUF484; Region: DUF484; cl01228 983545000632 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 983545000633 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 983545000634 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 983545000635 diaminopimelate decarboxylase; Region: lysA; TIGR01048 983545000636 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 983545000637 active site 983545000638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545000639 substrate binding site [chemical binding]; other site 983545000640 catalytic residues [active] 983545000641 dimer interface [polypeptide binding]; other site 983545000642 conserved hypothetical protein; Region: MJ1255; TIGR00661 983545000643 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 983545000644 active site 983545000645 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 983545000646 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545000647 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545000648 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545000649 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 983545000650 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545000651 domain; Region: Glyco_hydro_2; pfam00703 983545000652 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 983545000653 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 983545000654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 983545000655 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 983545000656 Protein of unknown function, DUF393; Region: DUF393; cl01136 983545000657 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545000658 NADP binding site [chemical binding]; other site 983545000659 homodimer interface [polypeptide binding]; other site 983545000660 active site 983545000661 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 983545000662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545000663 NAD(P) binding site [chemical binding]; other site 983545000664 active site 983545000665 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 983545000666 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545000667 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 983545000668 putative acyl-acceptor binding pocket; other site 983545000669 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 983545000670 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 983545000671 putative acyl-acceptor binding pocket; other site 983545000672 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 983545000673 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 983545000674 active site 983545000675 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 983545000676 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545000677 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983545000678 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 983545000679 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 983545000680 FMN binding site [chemical binding]; other site 983545000681 active site 983545000682 catalytic residues [active] 983545000683 substrate binding site [chemical binding]; other site 983545000684 Acyltransferase family; Region: Acyl_transf_3; pfam01757 983545000685 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 983545000686 trimer interface [polypeptide binding]; other site 983545000687 active site 983545000688 substrate binding site [chemical binding]; other site 983545000689 CoA binding site [chemical binding]; other site 983545000690 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 983545000691 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545000692 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545000693 classical (c) SDRs; Region: SDR_c; cd05233 983545000694 NAD(P) binding site [chemical binding]; other site 983545000695 active site 983545000696 phage shock protein A; Region: phageshock_pspA; TIGR02977 983545000697 phage shock protein PspA; Provisional; Region: PRK10698 983545000698 Protein of unknown function (DUF461); Region: DUF461; cl01071 983545000699 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 983545000700 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 983545000701 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545000702 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 983545000703 FAD binding pocket [chemical binding]; other site 983545000704 FAD binding motif [chemical binding]; other site 983545000705 catalytic residues [active] 983545000706 NAD binding pocket [chemical binding]; other site 983545000707 phosphate binding motif [ion binding]; other site 983545000708 beta-alpha-beta structure motif; other site 983545000709 sulfite reductase subunit beta; Provisional; Region: PRK13504 983545000710 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545000711 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545000712 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983545000713 Active Sites [active] 983545000714 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 983545000715 Response regulator receiver domain; Region: Response_reg; pfam00072 983545000716 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 983545000717 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000718 metal binding site [ion binding]; metal-binding site 983545000719 active site 983545000720 I-site; other site 983545000721 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000722 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 983545000723 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 983545000724 Di-iron ligands [ion binding]; other site 983545000725 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 983545000726 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 983545000727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545000728 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 983545000729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545000730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545000731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545000732 active site 983545000733 phosphorylation site [posttranslational modification] 983545000734 intermolecular recognition site; other site 983545000735 dimerization interface [polypeptide binding]; other site 983545000736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545000737 DNA binding residues [nucleotide binding] 983545000738 dimerization interface [polypeptide binding]; other site 983545000739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545000740 S-adenosylmethionine binding site [chemical binding]; other site 983545000741 tRNA mo(5)U34 methyltransferase; Provisional; Region: PRK15068 983545000742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545000743 S-adenosylmethionine binding site [chemical binding]; other site 983545000744 alanine racemase; Reviewed; Region: alr; PRK00053 983545000745 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 983545000746 active site 983545000747 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545000748 substrate binding site [chemical binding]; other site 983545000749 catalytic residues [active] 983545000750 dimer interface [polypeptide binding]; other site 983545000751 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 983545000752 homodimer interface [polypeptide binding]; other site 983545000753 substrate-cofactor binding pocket; other site 983545000754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000755 Aminotransferase class IV; Region: Aminotran_4; pfam01063 983545000756 catalytic residue [active] 983545000757 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 983545000758 OsmC-like protein; Region: OsmC; cl00767 983545000759 hypothetical protein; Provisional; Region: PRK05939 983545000760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545000761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545000762 catalytic residue [active] 983545000763 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 983545000764 putative acyl-acceptor binding pocket; other site 983545000765 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 983545000766 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 983545000767 phosphopeptide binding site; other site 983545000768 Protein of unknown function (DUF833); Region: DUF833; cl01315 983545000769 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545000770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000771 homodimer interface [polypeptide binding]; other site 983545000772 catalytic residue [active] 983545000773 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 983545000774 RNA/DNA binding site [nucleotide binding]; other site 983545000775 RRM dimerization site [polypeptide binding]; other site 983545000776 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 983545000777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545000778 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 983545000779 dimerization interface [polypeptide binding]; other site 983545000780 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 983545000781 active site clefts [active] 983545000782 zinc binding site [ion binding]; other site 983545000783 dimer interface [polypeptide binding]; other site 983545000784 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545000785 Sulfate transporter family; Region: Sulfate_transp; cl00967 983545000786 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545000787 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 983545000788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545000789 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 983545000790 putative ADP-binding pocket [chemical binding]; other site 983545000791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545000792 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545000793 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545000794 Bacterial sugar transferase; Region: Bac_transf; cl00939 983545000795 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 983545000796 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 983545000797 putative trimer interface [polypeptide binding]; other site 983545000798 putative CoA binding site [chemical binding]; other site 983545000799 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983545000800 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545000801 inhibitor-cofactor binding pocket; inhibition site 983545000802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000803 catalytic residue [active] 983545000804 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 983545000805 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545000806 NAD(P) binding site [chemical binding]; other site 983545000807 homodimer interface [polypeptide binding]; other site 983545000808 substrate binding site [chemical binding]; other site 983545000809 active site 983545000810 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545000811 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545000812 SLBB domain; Region: SLBB; pfam10531 983545000813 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 983545000814 Chain length determinant protein; Region: Wzz; cl01623 983545000815 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 983545000816 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 983545000817 FAD binding domain; Region: FAD_binding_4; pfam01565 983545000818 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 983545000819 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 983545000820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545000821 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 983545000822 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 983545000823 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 983545000824 elongation factor Tu; Reviewed; Region: PRK00049 983545000825 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 983545000826 G1 box; other site 983545000827 GEF interaction site [polypeptide binding]; other site 983545000828 GTP/Mg2+ binding site [chemical binding]; other site 983545000829 Switch I region; other site 983545000830 G2 box; other site 983545000831 G3 box; other site 983545000832 Switch II region; other site 983545000833 G4 box; other site 983545000834 G5 box; other site 983545000835 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 983545000836 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 983545000837 Antibiotic Binding Site [chemical binding]; other site 983545000838 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545000839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 983545000840 substrate binding pocket [chemical binding]; other site 983545000841 membrane-bound complex binding site; other site 983545000842 hinge residues; other site 983545000843 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 983545000844 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 983545000845 active site 983545000846 catalytic tetrad [active] 983545000847 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 983545000848 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545000849 FAD binding site [chemical binding]; other site 983545000850 substrate binding pocket [chemical binding]; other site 983545000851 catalytic base [active] 983545000852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000853 metal binding site [ion binding]; metal-binding site 983545000854 active site 983545000855 I-site; other site 983545000856 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000857 Rab family. Rab GTPases form the largest family within the Ras superfamily. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. Rab GTPases are small, monomeric proteins that function...; Region: Rab; cd00154 983545000858 Rab subfamily motif 1 (RabSF1); other site 983545000859 G1 box; other site 983545000860 GTP/Mg2+ binding site [chemical binding]; other site 983545000861 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 983545000862 Rab subfamily motif 2 (RabSF2); other site 983545000863 Switch I region; other site 983545000864 G2 box; other site 983545000865 effector interaction site; other site 983545000866 GDI interaction site; other site 983545000867 Rab family motif 1 (RabF1); other site 983545000868 GEF interaction site [polypeptide binding]; other site 983545000869 Rab family motif 2 (RabF2); other site 983545000870 G3 box; other site 983545000871 Switch II region; other site 983545000872 Rab family motif 3 (RabF3); other site 983545000873 Rab family motif 4 (RabF4); other site 983545000874 Rab family motif 5 (RabF5); other site 983545000875 Rab subfamily motif 3 (RabSF3); other site 983545000876 G4 box; other site 983545000877 G5 box; other site 983545000878 Rab subfamily motif 4 (RabSF4); other site 983545000879 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545000880 ligand binding site [chemical binding]; other site 983545000881 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 983545000882 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545000883 ferrochelatase; Reviewed; Region: hemH; PRK00035 983545000884 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 983545000885 C-terminal domain interface [polypeptide binding]; other site 983545000886 active site 983545000887 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 983545000888 active site 983545000889 N-terminal domain interface [polypeptide binding]; other site 983545000890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545000891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545000892 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545000893 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 983545000894 putative C-terminal domain interface [polypeptide binding]; other site 983545000895 putative GSH binding site (G-site) [chemical binding]; other site 983545000896 putative dimer interface [polypeptide binding]; other site 983545000897 GST_C family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_C_GTT2_like; cd03182 983545000898 putative N-terminal domain interface [polypeptide binding]; other site 983545000899 putative dimer interface [polypeptide binding]; other site 983545000900 putative substrate binding pocket (H-site) [chemical binding]; other site 983545000901 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 983545000902 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 983545000903 C-terminal domain interface [polypeptide binding]; other site 983545000904 GSH binding site (G-site) [chemical binding]; other site 983545000905 dimer interface [polypeptide binding]; other site 983545000906 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 983545000907 dimer interface [polypeptide binding]; other site 983545000908 N-terminal domain interface [polypeptide binding]; other site 983545000909 putative substrate binding pocket (H-site) [chemical binding]; other site 983545000910 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 983545000911 FtsH protease regulator HflC; Provisional; Region: PRK11029 983545000912 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 983545000913 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 983545000914 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 983545000915 HflK protein; Region: hflK; TIGR01933 983545000916 GTPase HflX; Provisional; Region: PRK11058 983545000917 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 983545000918 G1 box; other site 983545000919 GTP/Mg2+ binding site [chemical binding]; other site 983545000920 Switch I region; other site 983545000921 G2 box; other site 983545000922 G3 box; other site 983545000923 Switch II region; other site 983545000924 G4 box; other site 983545000925 G5 box; other site 983545000926 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 983545000927 Sm1 motif; other site 983545000928 intra - hexamer interaction site; other site 983545000929 inter - hexamer interaction site [polypeptide binding]; other site 983545000930 nucleotide binding pocket [chemical binding]; other site 983545000931 Sm2 motif; other site 983545000932 IPP transferase; Region: IPPT; cl00403 983545000933 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 983545000934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545000935 ATP binding site [chemical binding]; other site 983545000936 Mg2+ binding site [ion binding]; other site 983545000937 G-X-G motif; other site 983545000938 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 983545000939 ATP binding site [chemical binding]; other site 983545000940 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 983545000941 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 983545000942 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 983545000943 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 983545000944 active site 983545000945 metal binding site [ion binding]; metal-binding site 983545000946 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545000947 putative peptidoglycan binding site; other site 983545000948 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 983545000949 putative carbohydrate kinase; Provisional; Region: PRK10565 983545000950 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 983545000951 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 983545000952 putative substrate binding site [chemical binding]; other site 983545000953 putative ATP binding site [chemical binding]; other site 983545000954 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 983545000955 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 983545000956 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 983545000957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545000958 S-adenosylmethionine binding site [chemical binding]; other site 983545000959 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 983545000960 NAD binding site [chemical binding]; other site 983545000961 active site 983545000962 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 983545000963 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545000964 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545000965 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 983545000966 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 983545000967 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 983545000968 tetramer interface [polypeptide binding]; other site 983545000969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545000970 catalytic residue [active] 983545000971 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 983545000972 N-carbamolyputrescine amidase; Region: PLN02747 983545000973 putative active site; other site 983545000974 catalytic triad [active] 983545000975 putative dimer interface [polypeptide binding]; other site 983545000976 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 983545000977 agmatine deiminase; Region: agmatine_aguA; TIGR03380 983545000978 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545000979 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 983545000980 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 983545000981 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 983545000982 dimerization interface [polypeptide binding]; other site 983545000983 active site 983545000984 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545000985 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545000986 PAS domain S-box; Region: sensory_box; TIGR00229 983545000987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545000988 metal binding site [ion binding]; metal-binding site 983545000989 active site 983545000990 I-site; other site 983545000991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545000992 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 983545000993 Cytochrome c; Region: Cytochrom_C; cl11414 983545000994 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545000995 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 983545000996 putative C-terminal domain interface [polypeptide binding]; other site 983545000997 putative GSH binding site (G-site) [chemical binding]; other site 983545000998 putative dimer interface [polypeptide binding]; other site 983545000999 GST_C family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_C_GTT1_like; cd03189 983545001000 putative N-terminal domain interface [polypeptide binding]; other site 983545001001 putative dimer interface [polypeptide binding]; other site 983545001002 putative substrate binding pocket (H-site) [chemical binding]; other site 983545001003 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox' sequence; Region: Met_repressor_MetJ; cd00490 983545001004 dimerization interface [polypeptide binding]; other site 983545001005 DNA binding site [nucleotide binding] 983545001006 corepressor binding sites; other site 983545001007 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 983545001008 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 983545001009 FAD binding site [chemical binding]; other site 983545001010 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 983545001011 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 983545001012 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 983545001013 Serine carboxypeptidase S28; Region: Peptidase_S28; pfam05577 983545001014 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 983545001015 putative active site [active] 983545001016 dimerization interface [polypeptide binding]; other site 983545001017 putative tRNAtyr binding site [nucleotide binding]; other site 983545001018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001020 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545001021 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 983545001022 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545001023 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 983545001024 [2Fe-2S] cluster binding site [ion binding]; other site 983545001025 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 983545001026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545001027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545001028 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 983545001029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545001030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545001031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545001032 Cytochrome P450; Region: p450; cl12078 983545001033 Uncharacterized conserved protein [Function unknown]; Region: COG2128 983545001034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001035 putative substrate translocation pore; other site 983545001036 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545001037 Cytochrome P450; Region: p450; cl12078 983545001038 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545001039 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545001040 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001041 active site 983545001042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001043 active site 983545001044 enoyl-CoA hydratase; Provisional; Region: PRK09245 983545001045 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545001046 substrate binding site [chemical binding]; other site 983545001047 oxyanion hole (OAH) forming residues; other site 983545001048 trimer interface [polypeptide binding]; other site 983545001049 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545001050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545001051 active site 983545001052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545001053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545001054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545001055 dimerization interface [polypeptide binding]; other site 983545001056 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 983545001057 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 983545001058 dimer interface [polypeptide binding]; other site 983545001059 PYR/PP interface [polypeptide binding]; other site 983545001060 TPP binding site [chemical binding]; other site 983545001061 substrate binding site [chemical binding]; other site 983545001062 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 983545001063 TPP-binding site [chemical binding]; other site 983545001064 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 983545001065 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545001066 Ligand binding site [chemical binding]; other site 983545001067 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545001068 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545001069 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983545001070 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 983545001071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001072 putative substrate translocation pore; other site 983545001073 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545001074 Ligand Binding Site [chemical binding]; other site 983545001075 Uncharacterized conserved protein [Function unknown]; Region: COG3945 983545001076 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 983545001077 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 983545001078 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545001079 active site 983545001080 metal binding site [ion binding]; metal-binding site 983545001081 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545001082 classical (c) SDRs; Region: SDR_c; cd05233 983545001083 NAD(P) binding site [chemical binding]; other site 983545001084 active site 983545001085 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 983545001086 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545001087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545001088 Bacterial transcriptional regulator; Region: IclR; pfam01614 983545001089 lipid-transfer protein; Provisional; Region: PRK07855 983545001090 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 983545001091 active site 983545001092 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 983545001093 DUF35 OB-fold domain; Region: DUF35; pfam01796 983545001094 short chain dehydrogenase; Provisional; Region: PRK12828 983545001095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001096 NAD(P) binding site [chemical binding]; other site 983545001097 active site 983545001098 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545001099 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 983545001100 iron-sulfur cluster [ion binding]; other site 983545001101 [2Fe-2S] cluster binding site [ion binding]; other site 983545001102 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 983545001103 beta subunit interface [polypeptide binding]; other site 983545001104 alpha subunit interface [polypeptide binding]; other site 983545001105 active site 983545001106 substrate binding site [chemical binding]; other site 983545001107 Fe binding site [ion binding]; other site 983545001108 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 983545001109 inter-subunit interface; other site 983545001110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545001111 putative substrate translocation pore; other site 983545001112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545001113 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545001114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 983545001115 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 983545001116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545001117 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 983545001118 short chain dehydrogenase; Validated; Region: PRK08589 983545001119 classical (c) SDRs; Region: SDR_c; cd05233 983545001120 NAD(P) binding site [chemical binding]; other site 983545001121 active site 983545001122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545001123 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 983545001124 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545001125 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 983545001126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001127 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545001128 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545001129 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 983545001130 dimer interface [polypeptide binding]; other site 983545001131 active site 983545001132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545001133 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 983545001134 putative NAD(P) binding site [chemical binding]; other site 983545001135 putative active site [active] 983545001136 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 983545001137 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545001138 photosystem II stability/assembly factor; Provisional; Region: PLN00033 983545001139 Ycf48-like protein; Provisional; Region: PRK13684 983545001140 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545001141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545001142 active site 983545001143 metal binding site [ion binding]; metal-binding site 983545001144 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545001145 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545001146 substrate binding site [chemical binding]; other site 983545001147 oxyanion hole (OAH) forming residues; other site 983545001148 trimer interface [polypeptide binding]; other site 983545001149 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 983545001150 classical (c) SDRs; Region: SDR_c; cd05233 983545001151 NAD(P) binding site [chemical binding]; other site 983545001152 active site 983545001153 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545001154 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 983545001155 NAD(P) binding site [chemical binding]; other site 983545001156 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 983545001157 homodecamer interface [polypeptide binding]; other site 983545001158 GTP cyclohydrolase I; Provisional; Region: PLN03044 983545001159 active site 983545001160 putative catalytic site residues [active] 983545001161 zinc binding site [ion binding]; other site 983545001162 GTP-CH-I/GFRP interaction surface; other site 983545001163 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 983545001164 putative active site [active] 983545001165 putative metal binding residues [ion binding]; other site 983545001166 signature motif; other site 983545001167 putative triphosphate binding site [ion binding]; other site 983545001168 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 983545001169 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 983545001170 putative active site [active] 983545001171 putative NTP binding site [chemical binding]; other site 983545001172 putative nucleic acid binding site [nucleotide binding]; other site 983545001173 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 983545001174 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 983545001175 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 983545001176 putative transposase OrfB; Reviewed; Region: PHA02517 983545001177 Integrase core domain; Region: rve; cl01316 983545001178 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 983545001179 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 983545001180 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 983545001181 generic binding surface I; other site 983545001182 generic binding surface II; other site 983545001183 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 983545001184 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545001185 Phage integrase family; Region: Phage_integrase; pfam00589 983545001186 DNA binding site [nucleotide binding] 983545001187 Int/Topo IB signature motif; other site 983545001188 active site 983545001189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545001190 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 983545001191 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 983545001192 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 983545001193 dimerization interface [polypeptide binding]; other site 983545001194 putative active cleft [active] 983545001195 alpha-glucosidase; Provisional; Region: PRK10137 983545001196 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 983545001197 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545001198 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545001199 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545001200 Sodium:solute symporter family; Region: SSF; cl00456 983545001201 MOFRL family; Region: MOFRL; cl01013 983545001202 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 983545001203 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 983545001204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545001205 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 983545001206 HemY protein N-terminus; Region: HemY_N; pfam07219 983545001207 HemX; Region: HemX; cl14667 983545001208 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 983545001209 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 983545001210 active site 983545001211 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 983545001212 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 983545001213 domain interfaces; other site 983545001214 active site 983545001215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001216 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 983545001217 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545001218 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cd00503 983545001219 putative iron binding site [ion binding]; other site 983545001220 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 983545001221 catalytic site [active] 983545001222 G-X2-G-X-G-K; other site 983545001223 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 983545001224 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 983545001225 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545001226 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 983545001227 synthetase active site [active] 983545001228 NTP binding site [chemical binding]; other site 983545001229 metal binding site [ion binding]; metal-binding site 983545001230 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 983545001231 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 983545001232 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 983545001233 homotrimer interaction site [polypeptide binding]; other site 983545001234 putative active site [active] 983545001235 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 983545001236 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545001237 C-terminal; Region: SpoU_methylas_C; pfam12105 983545001238 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545001239 putative catalytic residues [active] 983545001240 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 983545001241 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 983545001242 generic binding surface II; other site 983545001243 ssDNA binding site; other site 983545001244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545001245 ATP binding site [chemical binding]; other site 983545001246 putative Mg++ binding site [ion binding]; other site 983545001247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001248 nucleotide binding region [chemical binding]; other site 983545001249 ATP-binding site [chemical binding]; other site 983545001250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545001251 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 983545001252 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 983545001253 catalytic triad [active] 983545001254 dimer interface [polypeptide binding]; other site 983545001255 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 983545001256 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 983545001257 Walker A/P-loop; other site 983545001258 ATP binding site [chemical binding]; other site 983545001259 Q-loop/lid; other site 983545001260 ABC transporter signature motif; other site 983545001261 Walker B; other site 983545001262 D-loop; other site 983545001263 H-loop/switch region; other site 983545001264 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545001265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983545001266 Histidine kinase; Region: HisKA_3; pfam07730 983545001267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545001268 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545001269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545001270 active site 983545001271 phosphorylation site [posttranslational modification] 983545001272 intermolecular recognition site; other site 983545001273 dimerization interface [polypeptide binding]; other site 983545001274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545001275 DNA binding residues [nucleotide binding] 983545001276 dimerization interface [polypeptide binding]; other site 983545001277 Peptidase family M48; Region: Peptidase_M48; cl12018 983545001278 Putative cyclase; Region: Cyclase; cl00814 983545001279 Predicted flavoproteins [General function prediction only]; Region: COG2081 983545001280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545001281 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545001282 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545001283 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 983545001284 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 983545001285 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 983545001286 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 983545001287 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 983545001288 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545001289 Walker A/P-loop; other site 983545001290 ATP binding site [chemical binding]; other site 983545001291 Q-loop/lid; other site 983545001292 ABC transporter signature motif; other site 983545001293 Walker B; other site 983545001294 D-loop; other site 983545001295 H-loop/switch region; other site 983545001296 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 983545001297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 983545001298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545001299 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 983545001300 Protein of unknown function, DUF547; Region: DUF547; pfam04784 983545001301 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545001302 mercuric reductase; Validated; Region: PRK06370 983545001303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545001304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545001305 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545001306 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545001307 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545001308 sugar efflux transporter; Region: 2A0120; TIGR00899 983545001309 PAS domain S-box; Region: sensory_box; TIGR00229 983545001310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545001311 putative active site [active] 983545001312 heme pocket [chemical binding]; other site 983545001313 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001314 metal binding site [ion binding]; metal-binding site 983545001315 active site 983545001316 I-site; other site 983545001317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545001318 DNA binding site [nucleotide binding] 983545001319 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545001320 Protein export membrane protein; Region: SecD_SecF; cl14618 983545001321 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545001322 M28, and M42; Region: Zinc_peptidase_like; cl14876 983545001323 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821 983545001324 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545001325 M28, and M42; Region: Zinc_peptidase_like; cl14876 983545001326 metal binding site [ion binding]; metal-binding site 983545001327 DsrE/DsrF-like family; Region: DrsE; cl00672 983545001328 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 983545001329 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 983545001330 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545001332 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 983545001333 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545001334 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545001335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545001336 catalytic residue [active] 983545001337 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 983545001338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545001339 active site 983545001340 motif I; other site 983545001341 motif II; other site 983545001342 ferredoxin-NADP reductase; Provisional; Region: PRK10926 983545001343 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 983545001344 FAD binding pocket [chemical binding]; other site 983545001345 FAD binding motif [chemical binding]; other site 983545001346 phosphate binding motif [ion binding]; other site 983545001347 beta-alpha-beta structure motif; other site 983545001348 NAD binding pocket [chemical binding]; other site 983545001349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545001350 siroheme synthase; Provisional; Region: cysG; PRK10637 983545001351 precorrin-2 dehydrogenase; Validated; Region: PRK06719 983545001352 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 983545001353 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 983545001354 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 983545001355 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 983545001356 ATP binding site [chemical binding]; other site 983545001357 Mg++ binding site [ion binding]; other site 983545001358 motif III; other site 983545001359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001360 nucleotide binding region [chemical binding]; other site 983545001361 ATP-binding site [chemical binding]; other site 983545001362 DbpA RNA binding domain; Region: DbpA; pfam03880 983545001363 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545001364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545001365 binding surface 983545001366 TPR motif; other site 983545001367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545001368 TPR motif; other site 983545001369 binding surface 983545001370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545001371 TPR motif; other site 983545001372 binding surface 983545001373 thioredoxin 2; Provisional; Region: PRK10996 983545001374 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 983545001375 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545001376 catalytic residues [active] 983545001377 Ion transport protein; Region: Ion_trans; pfam00520 983545001378 Polycystin cation channel; Region: PKD_channel; pfam08016 983545001379 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 983545001380 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 983545001381 putative active site [active] 983545001382 metal binding site [ion binding]; metal-binding site 983545001383 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 983545001384 active site 983545001385 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 983545001386 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); Region: HMG_CoA_R_NADP; TIGR00533 983545001387 tetramerization interface [polypeptide binding]; other site 983545001388 substrate binding pocket [chemical binding]; other site 983545001389 catalytic residues [active] 983545001390 inhibitor binding sites; inhibition site 983545001391 NADP(H) binding site [chemical binding]; other site 983545001392 Ferredoxin [Energy production and conversion]; Region: COG1146 983545001393 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 983545001394 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 983545001395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545001396 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 983545001397 Outer membrane efflux protein; Region: OEP; pfam02321 983545001398 Outer membrane efflux protein; Region: OEP; pfam02321 983545001399 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 983545001400 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 983545001401 dimer interface [polypeptide binding]; other site 983545001402 ADP-ribose binding site [chemical binding]; other site 983545001403 active site 983545001404 nudix motif; other site 983545001405 metal binding site [ion binding]; metal-binding site 983545001406 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 983545001407 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545001408 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 983545001409 active site 983545001410 metal binding site [ion binding]; metal-binding site 983545001411 hexamer interface [polypeptide binding]; other site 983545001412 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545001413 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 983545001414 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 983545001415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545001416 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 983545001417 anchoring element; other site 983545001418 dimer interface [polypeptide binding]; other site 983545001419 ATP binding site [chemical binding]; other site 983545001420 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 983545001421 active site 983545001422 metal binding site [ion binding]; metal-binding site 983545001423 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 983545001424 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 983545001425 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 983545001426 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 983545001427 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 983545001428 FeS/SAM binding site; other site 983545001429 elongation factor P; Validated; Region: PRK00529 983545001430 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 983545001431 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 983545001432 RNA binding site [nucleotide binding]; other site 983545001433 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 983545001434 RNA binding site [nucleotide binding]; other site 983545001435 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983545001436 lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462 983545001437 motif 1; other site 983545001438 dimer interface [polypeptide binding]; other site 983545001439 active site 983545001440 motif 2; other site 983545001441 motif 3; other site 983545001442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001443 metal binding site [ion binding]; metal-binding site 983545001444 active site 983545001445 I-site; other site 983545001446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001447 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 983545001448 substrate binding site [chemical binding]; other site 983545001449 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 983545001450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545001451 S-adenosylmethionine binding site [chemical binding]; other site 983545001452 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 983545001453 BolA-like protein; Region: BolA; cl00386 983545001454 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 983545001455 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 983545001456 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 983545001457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001458 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 983545001459 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 983545001460 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 983545001461 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 983545001462 FMN-binding domain; Region: FMN_bind; cl01081 983545001463 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 983545001464 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 983545001465 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 983545001466 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 983545001467 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+...; Region: NADH_quinone_reductase; cd06188 983545001468 FAD binding pocket [chemical binding]; other site 983545001469 FAD binding motif [chemical binding]; other site 983545001470 phosphate binding motif [ion binding]; other site 983545001471 beta-alpha-beta structure motif; other site 983545001472 NAD binding pocket [chemical binding]; other site 983545001473 ApbE family; Region: ApbE; cl00643 983545001474 Protein of unknown function (DUF539); Region: DUF539; cl01129 983545001475 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 983545001476 active site 983545001477 DNA polymerase IV; Validated; Region: PRK02406 983545001478 DNA binding site [nucleotide binding] 983545001479 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 983545001480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545001481 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 983545001482 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 983545001483 active site 983545001484 elongation factor G; Reviewed; Region: PRK00007 983545001485 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 983545001486 G1 box; other site 983545001487 putative GEF interaction site [polypeptide binding]; other site 983545001488 GTP/Mg2+ binding site [chemical binding]; other site 983545001489 Switch I region; other site 983545001490 G2 box; other site 983545001491 G3 box; other site 983545001492 Switch II region; other site 983545001493 G4 box; other site 983545001494 G5 box; other site 983545001495 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 983545001496 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 983545001497 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 983545001498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001499 metal binding site [ion binding]; metal-binding site 983545001500 active site 983545001501 I-site; other site 983545001502 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545001503 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545001504 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 983545001505 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545001506 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545001507 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545001508 active site 983545001509 adenine deaminase; Region: ade; TIGR01178 983545001510 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545001511 GAF domain; Region: GAF; cl00853 983545001512 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 983545001513 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 983545001514 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545001515 Walker A motif; other site 983545001516 ATP binding site [chemical binding]; other site 983545001517 Walker B motif; other site 983545001518 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 983545001519 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 983545001520 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 983545001521 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 983545001522 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 983545001523 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 983545001524 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 983545001525 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 983545001526 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 983545001527 putative translocon binding site; other site 983545001528 protein-rRNA interface [nucleotide binding]; other site 983545001529 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 983545001530 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 983545001531 G-X-X-G motif; other site 983545001532 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 983545001533 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 983545001534 23S rRNA interface [nucleotide binding]; other site 983545001535 5S rRNA interface [nucleotide binding]; other site 983545001536 putative antibiotic binding site [chemical binding]; other site 983545001537 L25 interface [polypeptide binding]; other site 983545001538 L27 interface [polypeptide binding]; other site 983545001539 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 983545001540 23S rRNA interface [nucleotide binding]; other site 983545001541 putative translocon interaction site; other site 983545001542 signal recognition particle (SRP54) interaction site; other site 983545001543 L23 interface [polypeptide binding]; other site 983545001544 trigger factor interaction site; other site 983545001545 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 983545001546 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cd00136 983545001547 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 983545001548 Active site serine [active] 983545001549 Domain of unknown function DUF11; Region: DUF11; cl03172 983545001550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001551 metal binding site [ion binding]; metal-binding site 983545001552 active site 983545001553 I-site; other site 983545001554 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545001555 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 983545001556 tetramer interface [polypeptide binding]; other site 983545001557 heme binding pocket [chemical binding]; other site 983545001558 NADPH binding site [chemical binding]; other site 983545001559 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545001560 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 983545001561 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 983545001562 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 983545001563 putative active site [active] 983545001564 putative substrate binding site [chemical binding]; other site 983545001565 putative cosubstrate binding site; other site 983545001566 catalytic site [active] 983545001567 2'-5' RNA ligase; Provisional; Region: PRK15124 983545001568 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 983545001569 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 983545001570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545001571 ATP binding site [chemical binding]; other site 983545001572 putative Mg++ binding site [ion binding]; other site 983545001573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 983545001574 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 983545001575 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 983545001576 Transglycosylase; Region: Transgly; cl07896 983545001577 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 983545001578 Nitrogen regulatory protein P-II; Region: P-II; cl00412 983545001579 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 983545001580 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545001581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545001582 active site 983545001583 phosphorylation site [posttranslational modification] 983545001584 intermolecular recognition site; other site 983545001585 dimerization interface [polypeptide binding]; other site 983545001586 Helix-turn-helix domain; Region: HTH_18; pfam12833 983545001587 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545001588 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545001589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545001590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001591 ATP binding site [chemical binding]; other site 983545001592 Mg2+ binding site [ion binding]; other site 983545001593 G-X-G motif; other site 983545001594 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 983545001595 cyclase homology domain; Region: CHD; cd07302 983545001596 nucleotidyl binding site; other site 983545001597 metal binding site [ion binding]; metal-binding site 983545001598 dimer interface [polypeptide binding]; other site 983545001599 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 983545001600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 983545001601 inhibitor-cofactor binding pocket; inhibition site 983545001602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545001603 catalytic residue [active] 983545001604 aspartate carbamoyltransferase; Provisional; Region: PRK08192 983545001605 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 983545001606 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 983545001607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545001608 FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl...; Region: FeeA_FeeB_like; cd01836 983545001609 active site 983545001610 catalytic triad [active] 983545001611 oxyanion hole [active] 983545001612 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 983545001613 active site 983545001614 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545001616 LysE type translocator; Region: LysE; cl00565 983545001617 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545001618 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 983545001619 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 983545001620 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545001621 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545001622 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 983545001623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545001624 dimer interface [polypeptide binding]; other site 983545001625 phosphorylation site [posttranslational modification] 983545001626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001627 ATP binding site [chemical binding]; other site 983545001628 Mg2+ binding site [ion binding]; other site 983545001629 G-X-G motif; other site 983545001630 Response regulator receiver domain; Region: Response_reg; pfam00072 983545001631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545001632 active site 983545001633 phosphorylation site [posttranslational modification] 983545001634 intermolecular recognition site; other site 983545001635 dimerization interface [polypeptide binding]; other site 983545001636 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545001637 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 983545001638 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 983545001639 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 983545001640 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 983545001641 CAP-like domain; other site 983545001642 Active site [active] 983545001643 primary dimer interface [polypeptide binding]; other site 983545001644 Carboxylesterase family; Region: COesterase; pfam00135 983545001645 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545001646 substrate binding pocket [chemical binding]; other site 983545001647 catalytic triad [active] 983545001648 An uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the the M14 family of metallocarboxypeptidases. This subgroup includes Pseudomonas aeruginosa AotO and related proteins. ASTE...; Region: M14_PaAOTO_like; cd06250 983545001649 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983545001650 putative active site [active] 983545001651 Zn-binding site [ion binding]; other site 983545001652 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545001653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545001654 putative peptidase; Provisional; Region: PRK11649 983545001655 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 983545001656 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545001657 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 983545001658 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 983545001659 active site 983545001660 HIGH motif; other site 983545001661 dimer interface [polypeptide binding]; other site 983545001662 KMSKS motif; other site 983545001663 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 983545001664 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 983545001665 CobD/Cbib protein; Region: CobD_Cbib; cl00561 983545001666 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983545001667 acetyl-CoA synthetase; Provisional; Region: PRK00174 983545001668 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 983545001669 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545001670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545001671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545001672 active site 983545001673 phosphorylation site [posttranslational modification] 983545001674 intermolecular recognition site; other site 983545001675 dimerization interface [polypeptide binding]; other site 983545001676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545001677 DNA binding residues [nucleotide binding] 983545001678 dimerization interface [polypeptide binding]; other site 983545001679 Sodium:solute symporter family; Region: SSF; cl00456 983545001680 PAS fold; Region: PAS_7; pfam12860 983545001681 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 983545001682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545001683 dimer interface [polypeptide binding]; other site 983545001684 phosphorylation site [posttranslational modification] 983545001685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545001686 ATP binding site [chemical binding]; other site 983545001687 Mg2+ binding site [ion binding]; other site 983545001688 G-X-G motif; other site 983545001689 Response regulator receiver domain; Region: Response_reg; pfam00072 983545001690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545001691 active site 983545001692 phosphorylation site [posttranslational modification] 983545001693 intermolecular recognition site; other site 983545001694 dimerization interface [polypeptide binding]; other site 983545001695 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 983545001696 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545001697 Sodium:solute symporter family; Region: SSF; cl00456 983545001698 FIST N domain; Region: FIST; pfam08495 983545001699 FIST C domain; Region: FIST_C; pfam10442 983545001700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001701 metal binding site [ion binding]; metal-binding site 983545001702 active site 983545001703 I-site; other site 983545001704 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545001705 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 983545001706 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545001707 ligand binding site [chemical binding]; other site 983545001708 flexible hinge region; other site 983545001709 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 983545001710 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545001711 metal binding triad; other site 983545001712 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 983545001713 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545001714 active site 983545001715 substrate binding site [chemical binding]; other site 983545001716 catalytic site [active] 983545001717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545001718 binding surface 983545001719 TPR motif; other site 983545001720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 983545001721 binding surface 983545001722 TPR motif; other site 983545001723 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 983545001724 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 983545001725 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 983545001726 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 983545001727 Nucleoside recognition; Region: Gate; cl00486 983545001728 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 983545001729 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 983545001730 ATP-binding site [chemical binding]; other site 983545001731 Sugar specificity; other site 983545001732 Pyrimidine base specificity; other site 983545001733 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545001734 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545001735 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545001736 putative metal binding site [ion binding]; other site 983545001737 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 983545001738 arginine repressor; Provisional; Region: PRK05066 983545001739 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 983545001740 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 983545001741 malate dehydrogenase; Provisional; Region: PRK05086 983545001742 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 983545001743 NAD binding site [chemical binding]; other site 983545001744 dimerization interface [polypeptide binding]; other site 983545001745 Substrate binding site [chemical binding]; other site 983545001746 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 983545001747 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 983545001748 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 983545001749 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 983545001750 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 983545001751 Cl- selectivity filter; other site 983545001752 Cl- binding residues [ion binding]; other site 983545001753 pore gating glutamate residue; other site 983545001754 dimer interface [polypeptide binding]; other site 983545001755 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 983545001756 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 983545001757 homodecamer interface [polypeptide binding]; other site 983545001758 GTP cyclohydrolase I; Provisional; Region: PLN03044 983545001759 active site 983545001760 putative catalytic site residues [active] 983545001761 zinc binding site [ion binding]; other site 983545001762 GTP-CH-I/GFRP interaction surface; other site 983545001763 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983545001764 Domain of unknown function DUF28; Region: DUF28; cl00361 983545001765 Predicted ATPase [General function prediction only]; Region: COG1485 983545001766 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 983545001767 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 983545001768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 983545001769 protein binding site [polypeptide binding]; other site 983545001770 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 983545001771 serine endoprotease; Provisional; Region: PRK10898 983545001772 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 983545001773 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 983545001774 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 983545001775 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 983545001776 hinge; other site 983545001777 active site 983545001778 BolA-like protein; Region: BolA; cl00386 983545001779 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545001780 anti sigma factor interaction site; other site 983545001781 regulatory phosphorylation site [posttranslational modification]; other site 983545001782 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 983545001783 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 983545001784 mce related protein; Region: MCE; cl03606 983545001785 Domain of unknown function DUF140; Region: DUF140; cl00510 983545001786 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 983545001787 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 983545001788 Walker A/P-loop; other site 983545001789 ATP binding site [chemical binding]; other site 983545001790 Q-loop/lid; other site 983545001791 ABC transporter signature motif; other site 983545001792 Walker B; other site 983545001793 D-loop; other site 983545001794 H-loop/switch region; other site 983545001795 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 983545001796 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 983545001797 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 983545001798 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 983545001799 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 983545001800 putative active site [active] 983545001801 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 983545001802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 983545001803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 983545001804 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 983545001805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 983545001806 OstA-like protein; Region: OstA; cl00844 983545001807 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 983545001808 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 983545001809 Walker A/P-loop; other site 983545001810 ATP binding site [chemical binding]; other site 983545001811 Q-loop/lid; other site 983545001812 ABC transporter signature motif; other site 983545001813 Walker B; other site 983545001814 D-loop; other site 983545001815 H-loop/switch region; other site 983545001816 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 983545001817 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 983545001818 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 983545001819 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 983545001820 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 983545001821 30S subunit binding site; other site 983545001822 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 983545001823 active site 983545001824 phosphorylation site [posttranslational modification] 983545001825 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 983545001826 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 983545001827 regulatory protein interface [polypeptide binding]; other site 983545001828 active site 983545001829 regulatory phosphorylation site [posttranslational modification]; other site 983545001830 Predicted transcriptional regulators [Transcription]; Region: COG1510 983545001831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545001832 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 983545001833 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 983545001834 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 983545001835 PhnA protein; Region: PhnA; pfam03831 983545001836 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 983545001837 putative acyl-acceptor binding pocket; other site 983545001838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545001839 Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418 983545001840 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 983545001841 active site 983545001842 substrate binding pocket [chemical binding]; other site 983545001843 dimer interface [polypeptide binding]; other site 983545001844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 983545001845 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545001846 substrate binding pocket [chemical binding]; other site 983545001847 membrane-bound complex binding site; other site 983545001848 hinge residues; other site 983545001849 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545001850 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 983545001851 substrate binding pocket [chemical binding]; other site 983545001852 membrane-bound complex binding site; other site 983545001853 hinge residues; other site 983545001854 enoyl-CoA hydratase; Provisional; Region: PRK06213 983545001855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545001856 substrate binding site [chemical binding]; other site 983545001857 oxyanion hole (OAH) forming residues; other site 983545001858 trimer interface [polypeptide binding]; other site 983545001859 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 983545001860 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 983545001861 ATP binding site [chemical binding]; other site 983545001862 Mg++ binding site [ion binding]; other site 983545001863 motif III; other site 983545001864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001865 nucleotide binding region [chemical binding]; other site 983545001866 ATP-binding site [chemical binding]; other site 983545001867 DbpA RNA binding domain; Region: DbpA; pfam03880 983545001868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545001869 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 983545001870 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 983545001871 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545001872 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 983545001873 Walker A/P-loop; other site 983545001874 ATP binding site [chemical binding]; other site 983545001875 Q-loop/lid; other site 983545001876 ABC transporter signature motif; other site 983545001877 Walker B; other site 983545001878 D-loop; other site 983545001879 H-loop/switch region; other site 983545001880 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 983545001881 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 983545001882 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 983545001883 putative homodimer interface [polypeptide binding]; other site 983545001884 KOW (Kyprides, Ouzounis, Woese) motif; Region: KOW; smart00739 983545001885 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 983545001886 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 983545001887 23S rRNA interface [nucleotide binding]; other site 983545001888 L7/L12 interface [polypeptide binding]; other site 983545001889 putative thiostrepton binding site; other site 983545001890 L25 interface [polypeptide binding]; other site 983545001891 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 983545001892 mRNA/rRNA interface [nucleotide binding]; other site 983545001893 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 983545001894 23S rRNA interface [nucleotide binding]; other site 983545001895 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 983545001896 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 983545001897 core dimer interface [polypeptide binding]; other site 983545001898 peripheral dimer interface [polypeptide binding]; other site 983545001899 L10 interface [polypeptide binding]; other site 983545001900 L11 interface [polypeptide binding]; other site 983545001901 putative EF-Tu interaction site [polypeptide binding]; other site 983545001902 putative EF-G interaction site [polypeptide binding]; other site 983545001903 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 983545001904 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 983545001905 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 983545001906 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 983545001907 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 983545001908 RPB11 interaction site [polypeptide binding]; other site 983545001909 RPB12 interaction site [polypeptide binding]; other site 983545001910 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 983545001911 RPB3 interaction site [polypeptide binding]; other site 983545001912 RPB1 interaction site [polypeptide binding]; other site 983545001913 RPB11 interaction site [polypeptide binding]; other site 983545001914 RPB10 interaction site [polypeptide binding]; other site 983545001915 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 983545001916 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 983545001917 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 983545001918 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 983545001919 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 983545001920 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 983545001921 unknown domain/DNA-directed RNA polymerase subunit A'' fusion protein; Provisional; Region: PRK14897 983545001922 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 983545001923 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 983545001924 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 983545001925 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 983545001926 DNA binding site [nucleotide binding] 983545001927 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 983545001928 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 983545001929 S17 interaction site [polypeptide binding]; other site 983545001930 S8 interaction site; other site 983545001931 16S rRNA interaction site [nucleotide binding]; other site 983545001932 streptomycin interaction site [chemical binding]; other site 983545001933 23S rRNA interaction site [nucleotide binding]; other site 983545001934 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 983545001935 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 983545001936 elongation factor G; Reviewed; Region: PRK00007 983545001937 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 983545001938 G1 box; other site 983545001939 putative GEF interaction site [polypeptide binding]; other site 983545001940 GTP/Mg2+ binding site [chemical binding]; other site 983545001941 Switch I region; other site 983545001942 G2 box; other site 983545001943 G3 box; other site 983545001944 Switch II region; other site 983545001945 G4 box; other site 983545001946 G5 box; other site 983545001947 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 983545001948 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 983545001949 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 983545001950 elongation factor Tu; Reviewed; Region: PRK00049 983545001951 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 983545001952 G1 box; other site 983545001953 GEF interaction site [polypeptide binding]; other site 983545001954 GTP/Mg2+ binding site [chemical binding]; other site 983545001955 Switch I region; other site 983545001956 G2 box; other site 983545001957 G3 box; other site 983545001958 Switch II region; other site 983545001959 G4 box; other site 983545001960 G5 box; other site 983545001961 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 983545001962 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 983545001963 Antibiotic Binding Site [chemical binding]; other site 983545001964 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545001965 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545001966 hypothetical protein; Provisional; Region: PRK11568 983545001967 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 983545001968 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 983545001969 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 983545001970 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 983545001971 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 983545001972 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545001973 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 983545001974 Sulfate transporter family; Region: Sulfate_transp; cl00967 983545001975 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545001976 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 983545001977 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545001978 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 983545001979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545001980 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545001981 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545001982 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545001983 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 983545001984 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545001985 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545001986 metal binding site [ion binding]; metal-binding site 983545001987 active site 983545001988 I-site; other site 983545001989 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 983545001990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545001991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545001992 catalytic residue [active] 983545001993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545001994 ATP binding site [chemical binding]; other site 983545001995 putative Mg++ binding site [ion binding]; other site 983545001996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545001997 nucleotide binding region [chemical binding]; other site 983545001998 ATP-binding site [chemical binding]; other site 983545001999 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545002000 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 983545002001 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545002002 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545002003 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545002004 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 983545002005 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545002006 CoenzymeA binding site [chemical binding]; other site 983545002007 subunit interaction site [polypeptide binding]; other site 983545002008 PHB binding site; other site 983545002009 Protein of unknown function, DUF; Region: DUF413; cl10479 983545002010 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 983545002011 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 983545002012 PYR/PP interface [polypeptide binding]; other site 983545002013 dimer interface [polypeptide binding]; other site 983545002014 TPP binding site [chemical binding]; other site 983545002015 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 983545002016 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 983545002017 TPP-binding site [chemical binding]; other site 983545002018 dimer interface [polypeptide binding]; other site 983545002019 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 983545002020 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 983545002021 putative valine binding site [chemical binding]; other site 983545002022 dimer interface [polypeptide binding]; other site 983545002023 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 983545002024 Thymidine kinase; Region: TK; cl00631 983545002025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002026 metal binding site [ion binding]; metal-binding site 983545002027 active site 983545002028 I-site; other site 983545002029 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002030 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545002031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002032 DNA-binding site [nucleotide binding]; DNA binding site 983545002033 FCD domain; Region: FCD; cl11656 983545002034 Sulfate transporter family; Region: Sulfate_transp; cl00967 983545002035 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 983545002036 Membrane transport protein; Region: Mem_trans; cl09117 983545002037 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545002038 short chain dehydrogenase; Provisional; Region: PRK08251 983545002039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002040 NAD(P) binding site [chemical binding]; other site 983545002041 active site 983545002042 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 983545002043 catalytic core [active] 983545002044 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 983545002045 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 983545002046 putative active site [active] 983545002047 putative substrate binding site [chemical binding]; other site 983545002048 ATP binding site [chemical binding]; other site 983545002049 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545002050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545002051 active site 983545002052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545002053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545002054 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545002055 substrate binding pocket [chemical binding]; other site 983545002056 dimerization interface [polypeptide binding]; other site 983545002057 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 983545002058 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 983545002059 active site 983545002060 catalytic residues [active] 983545002061 Putative Ig domain; Region: He_PIG; cl09256 983545002062 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 983545002063 MgtE intracellular N domain; Region: MgtE_N; cl15244 983545002064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 983545002065 Divalent cation transporter; Region: MgtE; cl00786 983545002066 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 983545002067 EamA-like transporter family; Region: EamA; cl01037 983545002068 galactokinase; Provisional; Region: PRK05101 983545002069 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 983545002070 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 983545002071 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 983545002072 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 983545002073 dimer interface [polypeptide binding]; other site 983545002074 active site 983545002075 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545002076 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 983545002077 NAD(P) binding site [chemical binding]; other site 983545002078 catalytic residues [active] 983545002079 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 983545002080 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 983545002081 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 983545002082 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 983545002083 inhibitor-cofactor binding pocket; inhibition site 983545002084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545002085 catalytic residue [active] 983545002086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545002087 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 983545002088 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 983545002089 glutamine binding [chemical binding]; other site 983545002090 catalytic triad [active] 983545002091 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545002092 Ligand binding site [chemical binding]; other site 983545002093 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545002094 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545002095 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983545002096 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545002097 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545002098 active site 983545002099 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545002100 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 983545002101 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545002102 SurA N-terminal domain; Region: SurA_N; pfam09312 983545002103 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 983545002104 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 983545002105 active site 983545002106 HIGH motif; other site 983545002107 dimer interface [polypeptide binding]; other site 983545002108 KMSKS motif; other site 983545002109 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 983545002110 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 983545002111 substrate binding site [chemical binding]; other site 983545002112 hexamer interface [polypeptide binding]; other site 983545002113 metal binding site [ion binding]; metal-binding site 983545002114 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 983545002115 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 983545002116 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 983545002117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 983545002118 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 983545002119 active site 983545002120 dimer interface [polypeptide binding]; other site 983545002121 metal binding site [ion binding]; metal-binding site 983545002122 shikimate kinase; Reviewed; Region: aroK; PRK00131 983545002123 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 983545002124 ADP binding site [chemical binding]; other site 983545002125 magnesium binding site [ion binding]; other site 983545002126 putative shikimate binding site; other site 983545002127 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 983545002128 Secretin and TonB N terminus short domain; Region: STN; pfam07660 983545002129 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 983545002130 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 983545002131 Pilus assembly protein, PilP; Region: PilP; cl01235 983545002132 Pilus assembly protein, PilO; Region: PilO; cl01234 983545002133 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 983545002134 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 983545002135 Competence protein A; Region: Competence_A; pfam11104 983545002136 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 983545002137 Transglycosylase; Region: Transgly; cl07896 983545002138 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 983545002139 malate dehydrogenase; Provisional; Region: PRK13529 983545002140 Malic enzyme, N-terminal domain; Region: malic; pfam00390 983545002141 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 983545002142 NAD(P) binding site [chemical binding]; other site 983545002143 PAS domain S-box; Region: sensory_box; TIGR00229 983545002144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002145 putative active site [active] 983545002146 heme pocket [chemical binding]; other site 983545002147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 983545002148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002149 ATP binding site [chemical binding]; other site 983545002150 Mg2+ binding site [ion binding]; other site 983545002151 G-X-G motif; other site 983545002152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545002154 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545002155 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 983545002156 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545002157 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 983545002158 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545002159 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545002160 catalytic residues [active] 983545002161 OsmC-like protein; Region: OsmC; cl00767 983545002162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545002164 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 983545002165 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 983545002166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002167 putative substrate translocation pore; other site 983545002168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002169 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 983545002170 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 983545002171 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 983545002172 dimer interface [polypeptide binding]; other site 983545002173 active site 983545002174 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545002175 catalytic residues [active] 983545002176 substrate binding site [chemical binding]; other site 983545002177 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 983545002178 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 983545002179 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 983545002180 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 983545002181 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 983545002182 Kelch motif; Region: Kelch_1; cl02701 983545002183 kelch-like protein; Provisional; Region: PHA03098 983545002184 Kelch motif; Region: Kelch_1; cl02701 983545002185 Kelch motif; Region: Kelch_1; cl02701 983545002186 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 983545002187 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 983545002188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545002189 catalytic residue [active] 983545002190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002191 metal binding site [ion binding]; metal-binding site 983545002192 active site 983545002193 I-site; other site 983545002194 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 983545002195 MAPEG family; Region: MAPEG; cl09190 983545002196 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002197 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 983545002198 Predicted ATPase [General function prediction only]; Region: COG3899 983545002199 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 983545002200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545002201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545002202 DNA binding residues [nucleotide binding] 983545002203 dimerization interface [polypeptide binding]; other site 983545002204 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002205 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545002206 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 983545002207 heme binding pocket [chemical binding]; other site 983545002208 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 983545002209 domain interactions; other site 983545002210 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002211 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002212 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545002213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545002214 binding surface 983545002215 TPR motif; other site 983545002216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545002217 binding surface 983545002218 TPR motif; other site 983545002219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545002220 TPR motif; other site 983545002221 binding surface 983545002222 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 983545002223 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 983545002224 short chain dehydrogenase; Provisional; Region: PRK12937 983545002225 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 983545002226 NADP binding site [chemical binding]; other site 983545002227 homodimer interface [polypeptide binding]; other site 983545002228 active site 983545002229 substrate binding site [chemical binding]; other site 983545002230 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 983545002231 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 983545002232 DctM-like transporters; Region: DctM; pfam06808 983545002233 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545002234 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545002235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545002236 EamA-like transporter family; Region: EamA; cl01037 983545002237 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545002238 EamA-like transporter family; Region: EamA; cl01037 983545002239 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 983545002240 catalytic residues [active] 983545002241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545002242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545002243 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 983545002244 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002245 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002246 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002247 N-terminal plug; other site 983545002248 ligand-binding site [chemical binding]; other site 983545002249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002250 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 983545002251 NAD(P) binding site [chemical binding]; other site 983545002252 active site 983545002253 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545002254 active site 983545002255 metal binding site [ion binding]; metal-binding site 983545002256 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545002257 active site 983545002258 metal binding site [ion binding]; metal-binding site 983545002259 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 983545002260 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 983545002261 Trp docking motif; other site 983545002262 active site 983545002263 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 983545002264 'Velcro' closure; other site 983545002265 DNA topoisomerase III; Provisional; Region: PRK07726 983545002266 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 983545002267 active site 983545002268 putative interdomain interaction site [polypeptide binding]; other site 983545002269 putative metal-binding site [ion binding]; other site 983545002270 putative nucleotide binding site [chemical binding]; other site 983545002271 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 983545002272 domain I; other site 983545002273 DNA binding groove [nucleotide binding] 983545002274 phosphate binding site [ion binding]; other site 983545002275 domain II; other site 983545002276 domain III; other site 983545002277 nucleotide binding site [chemical binding]; other site 983545002278 catalytic site [active] 983545002279 domain IV; other site 983545002280 PhoD-like phosphatase; Region: PhoD; pfam09423 983545002281 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545002282 active site 983545002283 metal binding site [ion binding]; metal-binding site 983545002284 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 983545002285 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 983545002286 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 983545002287 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 983545002288 putative chaperone; Provisional; Region: PRK11678 983545002289 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545002290 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545002291 active site 983545002292 metal binding site [ion binding]; metal-binding site 983545002293 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545002294 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002295 N-terminal plug; other site 983545002296 ligand-binding site [chemical binding]; other site 983545002297 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545002298 FecR protein; Region: FecR; pfam04773 983545002299 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545002300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545002301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 983545002302 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 983545002303 active site 983545002304 catalytic motif [active] 983545002305 Zn binding site [ion binding]; other site 983545002306 lipoprotein NlpI; Provisional; Region: PRK11189 983545002307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545002308 binding surface 983545002309 TPR motif; other site 983545002310 Quinolinate synthetase A protein; Region: NadA; cl00420 983545002311 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 983545002312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545002313 motif II; other site 983545002314 Predicted transcriptional regulator [Transcription]; Region: COG2378 983545002315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545002316 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545002317 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 983545002318 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002319 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002320 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545002321 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 983545002322 ligand binding site [chemical binding]; other site 983545002323 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545002324 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545002325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545002326 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545002327 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545002328 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 983545002329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002330 metal binding site [ion binding]; metal-binding site 983545002331 active site 983545002332 I-site; other site 983545002333 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 983545002334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002335 DNA-binding site [nucleotide binding]; DNA binding site 983545002336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545002337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545002338 homodimer interface [polypeptide binding]; other site 983545002339 catalytic residue [active] 983545002340 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 983545002341 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 983545002342 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 983545002343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002344 ATP binding site [chemical binding]; other site 983545002345 Mg2+ binding site [ion binding]; other site 983545002346 G-X-G motif; other site 983545002347 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545002348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545002349 active site 983545002350 phosphorylation site [posttranslational modification] 983545002351 intermolecular recognition site; other site 983545002352 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 983545002353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545002354 dimer interface [polypeptide binding]; other site 983545002355 phosphorylation site [posttranslational modification] 983545002356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002357 ATP binding site [chemical binding]; other site 983545002358 Mg2+ binding site [ion binding]; other site 983545002359 G-X-G motif; other site 983545002360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545002361 active site 983545002362 phosphorylation site [posttranslational modification] 983545002363 intermolecular recognition site; other site 983545002364 dimerization interface [polypeptide binding]; other site 983545002365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002366 metal binding site [ion binding]; metal-binding site 983545002367 active site 983545002368 I-site; other site 983545002369 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002370 Response regulator receiver domain; Region: Response_reg; pfam00072 983545002371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545002372 active site 983545002373 phosphorylation site [posttranslational modification] 983545002374 intermolecular recognition site; other site 983545002375 dimerization interface [polypeptide binding]; other site 983545002376 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545002377 Response regulator receiver domain; Region: Response_reg; pfam00072 983545002378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545002379 active site 983545002380 phosphorylation site [posttranslational modification] 983545002381 intermolecular recognition site; other site 983545002382 dimerization interface [polypeptide binding]; other site 983545002383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002384 metal binding site [ion binding]; metal-binding site 983545002385 active site 983545002386 I-site; other site 983545002387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002388 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002389 metal binding site [ion binding]; metal-binding site 983545002390 active site 983545002391 I-site; other site 983545002392 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545002393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545002394 Walker A motif; other site 983545002395 ATP binding site [chemical binding]; other site 983545002396 Walker B motif; other site 983545002397 arginine finger; other site 983545002398 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545002399 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545002400 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 983545002401 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 983545002402 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 983545002403 active site 983545002404 catalytic residues [active] 983545002405 glycerol kinase; Provisional; Region: glpK; PRK00047 983545002406 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 983545002407 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 983545002408 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545002409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002410 DNA-binding site [nucleotide binding]; DNA binding site 983545002411 FCD domain; Region: FCD; cl11656 983545002412 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 983545002413 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 983545002414 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 983545002415 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545002416 classical (c) SDRs; Region: SDR_c; cd05233 983545002417 NAD(P) binding site [chemical binding]; other site 983545002418 active site 983545002419 cell division protein MraZ; Reviewed; Region: PRK00326 983545002420 MraZ protein; Region: MraZ; pfam02381 983545002421 MraZ protein; Region: MraZ; pfam02381 983545002422 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 983545002423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545002424 Septum formation initiator; Region: DivIC; cl11433 983545002425 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 983545002426 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 983545002427 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 983545002428 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 983545002429 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002430 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002431 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002432 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 983545002433 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002436 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 983545002437 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 983545002438 Mg++ binding site [ion binding]; other site 983545002439 putative catalytic motif [active] 983545002440 putative substrate binding site [chemical binding]; other site 983545002441 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 983545002442 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002443 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545002444 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 983545002445 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 983545002446 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 983545002447 active site 983545002448 homodimer interface [polypeptide binding]; other site 983545002449 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 983545002450 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 983545002451 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545002452 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 983545002453 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 983545002454 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545002455 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 983545002456 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 983545002457 Cell division protein FtsQ; Region: FtsQ; pfam03799 983545002458 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 983545002459 Cell division protein FtsA; Region: FtsA; cl11496 983545002460 Cell division protein FtsA; Region: FtsA; cl11496 983545002461 cell division protein FtsZ; Validated; Region: PRK09330 983545002462 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 983545002463 nucleotide binding site [chemical binding]; other site 983545002464 SulA interaction site; other site 983545002465 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 983545002466 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 983545002467 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983545002468 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545002469 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 983545002470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 983545002471 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 983545002472 SEC-C motif; Region: SEC-C; cl12132 983545002473 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 983545002474 active site 983545002475 8-oxo-dGMP binding site [chemical binding]; other site 983545002476 nudix motif; other site 983545002477 metal binding site [ion binding]; metal-binding site 983545002478 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 983545002479 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983545002480 dimer interface [polypeptide binding]; other site 983545002481 active site 983545002482 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 983545002483 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_CaPnhB; cd02650 983545002484 active site 983545002485 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 983545002486 substrate binding site [chemical binding]; other site 983545002487 dimer interface [polypeptide binding]; other site 983545002488 ATP binding site [chemical binding]; other site 983545002489 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 983545002490 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 983545002491 proline aminopeptidase P II; Provisional; Region: PRK10879 983545002492 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 983545002493 active site 983545002494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545002495 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 983545002496 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 983545002497 putative deacylase active site [active] 983545002498 MarC family integral membrane protein; Region: MarC; cl00919 983545002499 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 983545002500 Protein of unknown function DUF58; Region: DUF58; pfam01882 983545002501 MoxR-like ATPases [General function prediction only]; Region: COG0714 983545002502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545002503 Walker A motif; other site 983545002504 ATP binding site [chemical binding]; other site 983545002505 Walker B motif; other site 983545002506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545002507 arginine finger; other site 983545002508 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 983545002509 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 983545002510 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 983545002511 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 983545002512 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545002513 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 983545002514 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 983545002515 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 983545002516 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 983545002517 active site 983545002518 MerC mercury resistance protein; Region: MerC; cl03934 983545002519 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545002520 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 983545002521 active site 983545002522 catalytic site [active] 983545002523 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545002524 EamA-like transporter family; Region: EamA; cl01037 983545002525 EamA-like transporter family; Region: EamA; cl01037 983545002526 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 983545002527 GTPase RsgA; Reviewed; Region: PRK12288 983545002528 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 983545002529 GTPase/OB domain interface [polypeptide binding]; other site 983545002530 GTPase/Zn-binding domain interface [polypeptide binding]; other site 983545002531 GTP/Mg2+ binding site [chemical binding]; other site 983545002532 G4 box; other site 983545002533 G5 box; other site 983545002534 G1 box; other site 983545002535 Switch I region; other site 983545002536 G2 box; other site 983545002537 G3 box; other site 983545002538 Switch II region; other site 983545002539 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 983545002540 putative active site [active] 983545002541 putative substrate binding site [chemical binding]; other site 983545002542 catalytic site [active] 983545002543 dimer interface [polypeptide binding]; other site 983545002544 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 983545002545 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 983545002546 Active site [active] 983545002547 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 983545002548 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545002549 active site 983545002550 ATP binding site [chemical binding]; other site 983545002551 substrate binding site [chemical binding]; other site 983545002552 activation loop (A-loop); other site 983545002553 cyanate hydratase; Validated; Region: PRK02866 983545002554 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 983545002555 oligomer interface [polypeptide binding]; other site 983545002556 active site 983545002557 PAS domain S-box; Region: sensory_box; TIGR00229 983545002558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002559 putative active site [active] 983545002560 heme pocket [chemical binding]; other site 983545002561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002562 PAS fold; Region: PAS_3; pfam08447 983545002563 putative active site [active] 983545002564 heme pocket [chemical binding]; other site 983545002565 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545002566 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545002567 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 983545002568 GAF domain; Region: GAF; cl00853 983545002569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545002570 Walker A motif; other site 983545002571 ATP binding site [chemical binding]; other site 983545002572 Walker B motif; other site 983545002573 arginine finger; other site 983545002574 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 983545002575 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 983545002576 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 983545002577 heme-binding site [chemical binding]; other site 983545002578 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 983545002579 FAD binding pocket [chemical binding]; other site 983545002580 FAD binding motif [chemical binding]; other site 983545002581 phosphate binding motif [ion binding]; other site 983545002582 beta-alpha-beta structure motif; other site 983545002583 NAD binding pocket [chemical binding]; other site 983545002584 Heme binding pocket [chemical binding]; other site 983545002585 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545002586 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 983545002587 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 983545002588 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 983545002589 active site 983545002590 uracil binding [chemical binding]; other site 983545002591 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 983545002592 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545002593 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545002594 Protein of unknown function (DUF502); Region: DUF502; cl01107 983545002595 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 983545002596 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983545002597 glutaredoxin 2; Provisional; Region: PRK10387 983545002598 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545002599 GST_C family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD (most GRXs range from 9-12kD). GRX2 adopts a GST fold containing an N-terminal thioredoxin-fold...; Region: GST_C_GRX2; cd03199 983545002600 putative dimer interface [polypeptide binding]; other site 983545002601 putative substrate binding pocket (H-site) [chemical binding]; other site 983545002602 N-terminal domain interface [polypeptide binding]; other site 983545002603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545002604 ATP binding site [chemical binding]; other site 983545002605 putative Mg++ binding site [ion binding]; other site 983545002606 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 983545002607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545002608 nucleotide binding region [chemical binding]; other site 983545002609 ATP-binding site [chemical binding]; other site 983545002610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002611 D-galactonate transporter; Region: 2A0114; TIGR00893 983545002612 putative substrate translocation pore; other site 983545002613 exonuclease subunit SbcC; Provisional; Region: PRK10246 983545002614 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545002615 Walker A/P-loop; other site 983545002616 ATP binding site [chemical binding]; other site 983545002617 Q-loop/lid; other site 983545002618 exonuclease subunit SbcC; Provisional; Region: PRK10246 983545002619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545002620 ABC transporter signature motif; other site 983545002621 Walker B; other site 983545002622 D-loop; other site 983545002623 H-loop/switch region; other site 983545002624 exonuclease subunit SbcD; Provisional; Region: PRK10966 983545002625 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 983545002626 active site 983545002627 metal binding site [ion binding]; metal-binding site 983545002628 DNA binding site [nucleotide binding] 983545002629 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 983545002630 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002631 N-terminal plug; other site 983545002632 ligand-binding site [chemical binding]; other site 983545002633 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 983545002634 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545002635 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545002636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545002637 putative active site [active] 983545002638 heme pocket [chemical binding]; other site 983545002639 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002640 metal binding site [ion binding]; metal-binding site 983545002641 active site 983545002642 I-site; other site 983545002643 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002644 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 983545002645 active site 983545002646 catalytic triad [active] 983545002647 oxyanion hole [active] 983545002648 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 983545002649 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545002650 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 983545002651 Walker A/P-loop; other site 983545002652 ATP binding site [chemical binding]; other site 983545002653 Q-loop/lid; other site 983545002654 ABC transporter signature motif; other site 983545002655 Walker B; other site 983545002656 D-loop; other site 983545002657 H-loop/switch region; other site 983545002658 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 983545002659 active site 983545002660 catalytic residues [active] 983545002661 metal binding site [ion binding]; metal-binding site 983545002662 lytic murein transglycosylase; Region: MltB_2; TIGR02283 983545002663 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545002664 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545002665 catalytic residue [active] 983545002666 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 983545002667 hypothetical protein; Provisional; Region: PRK01254 983545002668 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 983545002669 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 983545002670 proposed catalytic triad [active] 983545002671 conserved cys residue [active] 983545002672 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 983545002673 Strictosidine synthase; Region: Str_synth; pfam03088 983545002674 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 983545002675 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 983545002676 substrate binding site [chemical binding]; other site 983545002677 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 983545002678 substrate binding site [chemical binding]; other site 983545002679 ligand binding site [chemical binding]; other site 983545002680 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 983545002681 amidase; Provisional; Region: PRK08137 983545002682 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 983545002683 aspartate kinase III; Validated; Region: PRK09084 983545002684 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in...; Region: AAK_AKiii-LysC-EC; cd04258 983545002685 nucleotide binding site [chemical binding]; other site 983545002686 putative catalytic residues [active] 983545002687 aspartate binding site [chemical binding]; other site 983545002688 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 983545002689 lysine allosteric regulatory site; other site 983545002690 dimer interface [polypeptide binding]; other site 983545002691 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 983545002692 dimer interface [polypeptide binding]; other site 983545002693 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545002694 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545002695 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 983545002696 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 983545002697 active site 983545002698 metal binding site [ion binding]; metal-binding site 983545002699 Protein of unknown function (DUF525); Region: DUF525; cl01119 983545002700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545002701 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 983545002702 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 983545002703 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 983545002704 SurA N-terminal domain; Region: SurA_N; pfam09312 983545002705 PPIC-type PPIASE domain; Region: Rotamase; cl08278 983545002706 PPIC-type PPIASE domain; Region: Rotamase; cl08278 983545002707 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 983545002708 Organic solvent tolerance protein; Region: OstA_C; pfam04453 983545002709 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545002710 Phosphotransferase enzyme family; Region: APH; pfam01636 983545002711 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 983545002712 Substrate binding site [chemical binding]; other site 983545002713 metal binding site [ion binding]; metal-binding site 983545002714 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 983545002715 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 983545002716 putative metal binding site [ion binding]; other site 983545002717 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 983545002718 HSP70 interaction site [polypeptide binding]; other site 983545002719 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545002720 N-terminal plug; other site 983545002721 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 983545002722 ligand-binding site [chemical binding]; other site 983545002723 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545002724 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 983545002725 dimerization interface [polypeptide binding]; other site 983545002726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545002727 dimer interface [polypeptide binding]; other site 983545002728 phosphorylation site [posttranslational modification] 983545002729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002730 ATP binding site [chemical binding]; other site 983545002731 Mg2+ binding site [ion binding]; other site 983545002732 G-X-G motif; other site 983545002733 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545002734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545002735 active site 983545002736 phosphorylation site [posttranslational modification] 983545002737 intermolecular recognition site; other site 983545002738 dimerization interface [polypeptide binding]; other site 983545002739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545002740 DNA binding site [nucleotide binding] 983545002741 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545002742 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545002743 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545002744 Sulfatase; Region: Sulfatase; cl10460 983545002745 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 983545002746 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 983545002747 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 983545002748 homodimer interface [polypeptide binding]; other site 983545002749 substrate-cofactor binding pocket; other site 983545002750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545002751 catalytic residue [active] 983545002752 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 983545002753 MltA-interacting protein MipA; Region: MipA; cl01504 983545002754 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002755 HemX; Region: HemX; cl14667 983545002756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545002757 putative DNA binding site [nucleotide binding]; other site 983545002758 dimerization interface [polypeptide binding]; other site 983545002759 putative Zn2+ binding site [ion binding]; other site 983545002760 Low molecular weight phosphatase family; Region: LMWPc; cd00115 983545002761 Active site [active] 983545002762 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545002763 Membrane transport protein; Region: Mem_trans; cl09117 983545002764 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 983545002765 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 983545002766 putative trimer interface [polypeptide binding]; other site 983545002767 putative CoA binding site [chemical binding]; other site 983545002768 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 983545002769 ATP binding site [chemical binding]; other site 983545002770 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 983545002771 catalytic motif [active] 983545002772 Catalytic residue [active] 983545002773 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 983545002774 active site 983545002775 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 983545002776 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 983545002777 putative ligand binding site [chemical binding]; other site 983545002778 Protein of unknown function, DUF462; Region: DUF462; cl01190 983545002779 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 983545002780 YfcL protein; Region: YfcL; pfam08891 983545002781 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 983545002782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545002783 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 983545002784 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 983545002785 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983545002786 dimer interface [polypeptide binding]; other site 983545002787 active site 983545002788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545002789 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545002790 putative substrate translocation pore; other site 983545002791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545002792 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 983545002793 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 983545002794 Protein of unknown function (DUF1414); Region: DUF1414; cl01175 983545002795 Nucleoid-associated protein [General function prediction only]; Region: COG3081 983545002796 nucleoid-associated protein NdpA; Validated; Region: PRK00378 983545002797 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 983545002798 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545002799 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 983545002800 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 983545002801 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002802 metal binding site [ion binding]; metal-binding site 983545002803 active site 983545002804 I-site; other site 983545002805 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002806 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983545002807 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545002808 ligand binding site [chemical binding]; other site 983545002809 flexible hinge region; other site 983545002810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545002811 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 983545002812 intersubunit interface [polypeptide binding]; other site 983545002813 active site 983545002814 Zn2+ binding site [ion binding]; other site 983545002815 hydrolase; Region: PLN02578 983545002816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002817 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545002818 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 983545002819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002820 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 983545002821 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 983545002822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002823 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 983545002824 FimV N-terminal domain; Region: FimV_core; TIGR03505 983545002825 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 983545002826 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545002827 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545002828 metal binding site [ion binding]; metal-binding site 983545002829 active site 983545002830 I-site; other site 983545002831 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545002832 Protein of unknown function, DUF481; Region: DUF481; cl01213 983545002833 Protein of unknown function, DUF481; Region: DUF481; cl01213 983545002834 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545002835 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002836 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545002837 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 983545002838 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 983545002839 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 983545002840 active site 983545002841 Zn binding site [ion binding]; other site 983545002842 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 983545002843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545002844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545002845 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545002846 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545002847 E3 interaction surface; other site 983545002848 lipoyl attachment site [posttranslational modification]; other site 983545002849 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 983545002850 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545002851 E3 interaction surface; other site 983545002852 lipoyl attachment site [posttranslational modification]; other site 983545002853 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545002854 E3 interaction surface; other site 983545002855 lipoyl attachment site [posttranslational modification]; other site 983545002856 e3 binding domain; Region: E3_binding; pfam02817 983545002857 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 983545002858 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 983545002859 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 983545002860 dimer interface [polypeptide binding]; other site 983545002861 TPP-binding site [chemical binding]; other site 983545002862 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 983545002863 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545002864 DNA-binding site [nucleotide binding]; DNA binding site 983545002865 FCD domain; Region: FCD; cl11656 983545002866 CobD/Cbib protein; Region: CobD_Cbib; cl00561 983545002867 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 983545002868 amidase catalytic site [active] 983545002869 Zn binding residues [ion binding]; other site 983545002870 substrate binding site [chemical binding]; other site 983545002871 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 983545002872 catalytic motif [active] 983545002873 Catalytic residue [active] 983545002874 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 983545002875 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 983545002876 dimerization interface [polypeptide binding]; other site 983545002877 active site 983545002878 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 983545002879 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 983545002880 Pilin (bacterial filament); Region: Pilin; pfam00114 983545002881 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545002882 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 983545002883 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 983545002884 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 983545002885 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 983545002886 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 983545002887 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 983545002888 CoA-binding site [chemical binding]; other site 983545002889 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 983545002890 Domain of unknown function (DUF329); Region: DUF329; cl01144 983545002891 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 983545002892 catalytic triad [active] 983545002893 dimer interface [polypeptide binding]; other site 983545002894 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545002895 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545002896 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545002897 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545002898 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 983545002899 dimer interface [polypeptide binding]; other site 983545002900 substrate binding pocket (H-site) [chemical binding]; other site 983545002901 N-terminal domain interface [polypeptide binding]; other site 983545002902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545002903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545002904 ATP binding site [chemical binding]; other site 983545002905 Mg2+ binding site [ion binding]; other site 983545002906 G-X-G motif; other site 983545002907 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 983545002908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545002909 Peptidase family M48; Region: Peptidase_M48; cl12018 983545002910 S-adenosylmethionine synthetase; Validated; Region: PRK05250 983545002911 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 983545002912 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 983545002913 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 983545002914 transketolase; Reviewed; Region: PRK12753 983545002915 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 983545002916 TPP-binding site [chemical binding]; other site 983545002917 dimer interface [polypeptide binding]; other site 983545002918 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 983545002919 PYR/PP interface [polypeptide binding]; other site 983545002920 dimer interface [polypeptide binding]; other site 983545002921 TPP binding site [chemical binding]; other site 983545002922 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983545002923 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 983545002924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545002925 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983545002926 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 983545002927 substrate binding site [chemical binding]; other site 983545002928 hinge regions; other site 983545002929 ADP binding site [chemical binding]; other site 983545002930 catalytic site [active] 983545002931 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 983545002932 catalytic residue [active] 983545002933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545002934 exopolyphosphatase; Provisional; Region: PRK10854 983545002935 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 983545002936 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 983545002937 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 983545002938 domain interface [polypeptide binding]; other site 983545002939 active site 983545002940 catalytic site [active] 983545002941 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 983545002942 putative active site [active] 983545002943 catalytic site [active] 983545002944 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 983545002945 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 983545002946 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 983545002947 Phosphate transporter family; Region: PHO4; cl00396 983545002948 Phosphate transporter family; Region: PHO4; cl00396 983545002949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545002950 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 983545002951 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 983545002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545002953 dimer interface [polypeptide binding]; other site 983545002954 conserved gate region; other site 983545002955 putative PBP binding loops; other site 983545002956 ABC-ATPase subunit interface; other site 983545002957 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 983545002958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545002959 dimer interface [polypeptide binding]; other site 983545002960 conserved gate region; other site 983545002961 putative PBP binding loops; other site 983545002962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 983545002963 ABC-ATPase subunit interface; other site 983545002964 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 983545002965 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 983545002966 Walker A/P-loop; other site 983545002967 ATP binding site [chemical binding]; other site 983545002968 Q-loop/lid; other site 983545002969 ABC transporter signature motif; other site 983545002970 Walker B; other site 983545002971 D-loop; other site 983545002972 H-loop/switch region; other site 983545002973 transcriptional regulator PhoU; Provisional; Region: PRK11115 983545002974 PhoU domain; Region: PhoU; pfam01895 983545002975 PhoU domain; Region: PhoU; pfam01895 983545002976 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 983545002977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545002978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545002979 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 983545002980 dimerization interface [polypeptide binding]; other site 983545002981 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545002982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545002983 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 983545002984 DNA binding residues [nucleotide binding] 983545002985 V-type ATP synthase subunit I; Validated; Region: PRK05771 983545002986 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545002987 CoenzymeA binding site [chemical binding]; other site 983545002988 subunit interaction site [polypeptide binding]; other site 983545002989 PHB binding site; other site 983545002990 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 983545002991 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 983545002992 MgtC family; Region: MgtC; cl12207 983545002993 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 983545002994 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 983545002995 NAD binding site [chemical binding]; other site 983545002996 substrate binding site [chemical binding]; other site 983545002997 putative active site [active] 983545002998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545002999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545003000 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545003001 putative effector binding pocket; other site 983545003002 dimerization interface [polypeptide binding]; other site 983545003003 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 983545003004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003005 putative substrate translocation pore; other site 983545003006 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545003007 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 983545003008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545003009 putative substrate translocation pore; other site 983545003010 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 983545003011 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983545003012 dimer interface [polypeptide binding]; other site 983545003013 active site 983545003014 CoA binding pocket [chemical binding]; other site 983545003015 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 983545003016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003017 ATP binding site [chemical binding]; other site 983545003018 Mg2+ binding site [ion binding]; other site 983545003019 G-X-G motif; other site 983545003020 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 983545003021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545003022 active site 983545003023 phosphorylation site [posttranslational modification] 983545003024 intermolecular recognition site; other site 983545003025 dimerization interface [polypeptide binding]; other site 983545003026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545003027 Walker A motif; other site 983545003028 ATP binding site [chemical binding]; other site 983545003029 Walker B motif; other site 983545003030 arginine finger; other site 983545003031 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 983545003032 LrgA family; Region: LrgA; cl00608 983545003033 LrgB-like family; Region: LrgB; cl00596 983545003034 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545003035 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545003036 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 983545003037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545003038 HemN family oxidoreductase; Provisional; Region: PRK05660 983545003039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 983545003040 FeS/SAM binding site; other site 983545003041 HemN C-terminal region; Region: HemN_C; pfam06969 983545003042 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 983545003043 active site 983545003044 dimerization interface [polypeptide binding]; other site 983545003045 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545003046 short chain dehydrogenase; Provisional; Region: PRK06197 983545003047 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 983545003048 putative NAD(P) binding site [chemical binding]; other site 983545003049 active site 983545003050 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 983545003051 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545003052 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 983545003053 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 983545003054 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545003055 ATP binding site [chemical binding]; other site 983545003056 Mg++ binding site [ion binding]; other site 983545003057 motif III; other site 983545003058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545003059 nucleotide binding region [chemical binding]; other site 983545003060 ATP-binding site [chemical binding]; other site 983545003061 dUTPase; Region: dUTPase_2; pfam08761 983545003062 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 983545003063 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 983545003064 active site 983545003065 NTP binding site [chemical binding]; other site 983545003066 metal binding triad [ion binding]; metal-binding site 983545003067 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 983545003068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545003069 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 983545003070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545003071 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 983545003072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 983545003073 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545003074 substrate binding pocket [chemical binding]; other site 983545003075 membrane-bound complex binding site; other site 983545003076 hinge residues; other site 983545003077 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545003078 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545003079 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545003080 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545003081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545003082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545003083 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 983545003084 putative transporter; Provisional; Region: PRK11462 983545003085 putative transporter; Provisional; Region: PRK11462 983545003086 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 983545003087 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 983545003088 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 983545003089 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 983545003090 CreA protein; Region: CreA; cl01154 983545003091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545003092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545003093 DNA binding site [nucleotide binding] 983545003094 domain linker motif; other site 983545003095 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545003096 dimerization interface [polypeptide binding]; other site 983545003097 ligand binding site [chemical binding]; other site 983545003098 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 983545003099 substrate binding site [chemical binding]; other site 983545003100 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 983545003101 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 983545003102 substrate binding site [chemical binding]; other site 983545003103 ligand binding site [chemical binding]; other site 983545003104 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 983545003105 isocitrate dehydrogenase; Validated; Region: PRK06451 983545003106 2-isopropylmalate synthase; Validated; Region: PRK00915 983545003107 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 983545003108 active site 983545003109 catalytic residues [active] 983545003110 metal binding site [ion binding]; metal-binding site 983545003111 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 983545003112 enolase; Provisional; Region: eno; PRK00077 983545003113 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 983545003114 dimer interface [polypeptide binding]; other site 983545003115 metal binding site [ion binding]; metal-binding site 983545003116 substrate binding pocket [chemical binding]; other site 983545003117 CTP synthetase; Validated; Region: pyrG; PRK05380 983545003118 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 983545003119 Catalytic site [active] 983545003120 Active site [active] 983545003121 UTP binding site [chemical binding]; other site 983545003122 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 983545003123 active site 983545003124 putative oxyanion hole; other site 983545003125 catalytic triad [active] 983545003126 Response regulator receiver domain; Region: Response_reg; pfam00072 983545003127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545003128 active site 983545003129 phosphorylation site [posttranslational modification] 983545003130 intermolecular recognition site; other site 983545003131 dimerization interface [polypeptide binding]; other site 983545003132 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 983545003133 MutS domain I; Region: MutS_I; pfam01624 983545003134 MutS domain II; Region: MutS_II; pfam05188 983545003135 MutS family domain IV; Region: MutS_IV; pfam05190 983545003136 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 983545003137 Walker A/P-loop; other site 983545003138 ATP binding site [chemical binding]; other site 983545003139 Q-loop/lid; other site 983545003140 ABC transporter signature motif; other site 983545003141 Walker B; other site 983545003142 D-loop; other site 983545003143 H-loop/switch region; other site 983545003144 Competence-damaged protein; Region: CinA; cl00666 983545003145 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 983545003146 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 983545003147 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 983545003148 recombinase A; Provisional; Region: recA; PRK09354 983545003149 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 983545003150 hexamer interface [polypeptide binding]; other site 983545003151 Walker A motif; other site 983545003152 ATP binding site [chemical binding]; other site 983545003153 Walker B motif; other site 983545003154 Uncharacterized conserved protein [Function unknown]; Region: COG2850 983545003155 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 983545003156 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 983545003157 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 983545003158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545003159 Walker A/P-loop; other site 983545003160 ATP binding site [chemical binding]; other site 983545003161 Q-loop/lid; other site 983545003162 ABC transporter signature motif; other site 983545003163 Walker B; other site 983545003164 D-loop; other site 983545003165 H-loop/switch region; other site 983545003166 CcmB protein; Region: CcmB; cl01016 983545003167 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545003168 Heme exporter protein D (CcmD); Region: CcmD; cl11475 983545003169 CcmE; Region: CcmE; cl00994 983545003170 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545003171 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545003172 Cytochrome C biogenesis protein; Region: CcmH; cl01179 983545003173 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 983545003174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545003175 binding surface 983545003176 TPR motif; other site 983545003177 VacJ like lipoprotein; Region: VacJ; cl01073 983545003178 UDP-glucose 4-epimerase; Region: PLN02240 983545003179 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 983545003180 NAD binding site [chemical binding]; other site 983545003181 homodimer interface [polypeptide binding]; other site 983545003182 active site 983545003183 substrate binding site [chemical binding]; other site 983545003184 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 983545003185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 983545003186 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545003187 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 983545003188 SLBB domain; Region: SLBB; pfam10531 983545003189 SLBB domain; Region: SLBB; pfam10531 983545003190 SLBB domain; Region: SLBB; pfam10531 983545003191 Chain length determinant protein; Region: Wzz; cl01623 983545003192 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 983545003193 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545003194 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 983545003195 NAD(P) binding site [chemical binding]; other site 983545003196 homodimer interface [polypeptide binding]; other site 983545003197 substrate binding site [chemical binding]; other site 983545003198 active site 983545003199 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983545003200 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545003201 inhibitor-cofactor binding pocket; inhibition site 983545003202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545003203 catalytic residue [active] 983545003204 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003205 active site 983545003206 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 983545003207 NeuB family; Region: NeuB; cl00496 983545003208 SAF domain; Region: SAF; cl00555 983545003209 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003210 ligand binding site [chemical binding]; other site 983545003211 tetramer interface [polypeptide binding]; other site 983545003212 FOG: CBS domain [General function prediction only]; Region: COG0517 983545003213 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 983545003214 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 983545003215 Substrate binding site [chemical binding]; other site 983545003216 metal binding site [ion binding]; metal-binding site 983545003217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003218 active site 983545003219 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 983545003220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545003221 active site 983545003222 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 983545003223 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 983545003224 Mg++ binding site [ion binding]; other site 983545003225 putative catalytic motif [active] 983545003226 substrate binding site [chemical binding]; other site 983545003227 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 983545003228 SLBB-domain like (DUF1017); Region: DUF1017; pfam06251 983545003229 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 983545003230 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 983545003231 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 983545003232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003233 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 983545003234 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 983545003235 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 983545003236 active site 983545003237 tetramer interface [polypeptide binding]; other site 983545003238 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 983545003239 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 983545003240 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 983545003241 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 983545003242 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 983545003243 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 983545003244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 983545003245 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 983545003246 Syd protein; Region: Syd; cl06405 983545003247 hypothetical protein; Provisional; Region: PRK11239 983545003248 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 983545003249 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 983545003250 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 983545003251 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 983545003252 Domain of unknown function, DUF446; Region: DUF446; cl01187 983545003253 tRNA pseudouridine isomerase C: Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. TruC makes psi65 in tRNAs. This psi residue is not...; Region: PseudoU_synth_TruC; cd02563 983545003254 probable active site [active] 983545003255 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545003256 M28, and M42; Region: Zinc_peptidase_like; cl14876 983545003257 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions...; Region: PA_M28_2; cd04815 983545003258 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545003259 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 983545003260 metal binding site [ion binding]; metal-binding site 983545003261 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 983545003262 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 983545003263 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 983545003264 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 983545003265 active site 983545003266 Riboflavin kinase; Region: Flavokinase; pfam01687 983545003267 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 983545003268 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545003269 active site 983545003270 HIGH motif; other site 983545003271 nucleotide binding site [chemical binding]; other site 983545003272 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 983545003273 active site 983545003274 KMSKS motif; other site 983545003275 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 983545003276 tRNA binding surface [nucleotide binding]; other site 983545003277 anticodon binding site; other site 983545003278 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 983545003279 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 983545003280 lipoprotein signal peptidase; Provisional; Region: PRK14787 983545003281 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545003282 LytB protein; Region: LYTB; cl00507 983545003283 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 983545003284 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 983545003285 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 983545003286 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 983545003287 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545003288 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 983545003289 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 983545003290 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 983545003291 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 983545003292 Type II transport protein GspH; Region: GspH; pfam12019 983545003293 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 983545003294 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 983545003295 hypothetical protein; Provisional; Region: PRK10506 983545003296 hypothetical protein; Provisional; Region: PRK10557 983545003297 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 983545003298 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 983545003299 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 983545003300 homodimer interface [polypeptide binding]; other site 983545003301 NAD binding pocket [chemical binding]; other site 983545003302 ATP binding pocket [chemical binding]; other site 983545003303 Mg binding site [ion binding]; other site 983545003304 active-site loop [active] 983545003305 Nitrogen regulatory protein P-II; Region: P-II; cl00412 983545003306 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545003307 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 983545003308 putative global regulator; Reviewed; Region: PRK09559 983545003309 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 983545003310 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 983545003311 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545003312 active site 2 [active] 983545003313 active site 1 [active] 983545003314 L-aspartate oxidase; Provisional; Region: PRK09077 983545003315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545003316 domain; Region: Succ_DH_flav_C; pfam02910 983545003317 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 983545003318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545003319 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 983545003320 DNA binding residues [nucleotide binding] 983545003321 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 983545003322 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 983545003323 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 983545003324 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 983545003325 GTP-binding protein LepA; Provisional; Region: PRK05433 983545003326 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 983545003327 G1 box; other site 983545003328 putative GEF interaction site [polypeptide binding]; other site 983545003329 GTP/Mg2+ binding site [chemical binding]; other site 983545003330 Switch I region; other site 983545003331 G2 box; other site 983545003332 G3 box; other site 983545003333 Switch II region; other site 983545003334 G4 box; other site 983545003335 G5 box; other site 983545003336 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 983545003337 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 983545003338 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 983545003339 signal peptidase I; Provisional; Region: PRK10861 983545003340 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545003341 Catalytic site [active] 983545003342 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545003343 ribonuclease III; Reviewed; Region: rnc; PRK00102 983545003344 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 983545003345 dimerization interface [polypeptide binding]; other site 983545003346 active site 983545003347 metal binding site [ion binding]; metal-binding site 983545003348 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 983545003349 dsRNA binding site [nucleotide binding]; other site 983545003350 GTPase Era; Reviewed; Region: era; PRK00089 983545003351 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 983545003352 G1 box; other site 983545003353 GTP/Mg2+ binding site [chemical binding]; other site 983545003354 Switch I region; other site 983545003355 G2 box; other site 983545003356 Switch II region; other site 983545003357 G3 box; other site 983545003358 G4 box; other site 983545003359 G5 box; other site 983545003360 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 983545003361 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 983545003362 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545003363 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 983545003364 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545003365 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 983545003366 active site 983545003367 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 983545003368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545003369 Walker A/P-loop; other site 983545003370 ATP binding site [chemical binding]; other site 983545003371 Q-loop/lid; other site 983545003372 ABC transporter signature motif; other site 983545003373 Walker B; other site 983545003374 D-loop; other site 983545003375 H-loop/switch region; other site 983545003376 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545003377 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 983545003378 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 983545003379 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 983545003380 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 983545003381 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 983545003382 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 983545003383 homodimer interface [polypeptide binding]; other site 983545003384 NADP binding site [chemical binding]; other site 983545003385 substrate binding site [chemical binding]; other site 983545003386 trigger factor; Provisional; Region: tig; PRK01490 983545003387 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545003388 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 983545003389 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 983545003390 oligomer interface [polypeptide binding]; other site 983545003391 active site residues [active] 983545003392 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 983545003393 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 983545003394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545003395 Walker A motif; other site 983545003396 ATP binding site [chemical binding]; other site 983545003397 Walker B motif; other site 983545003398 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 983545003399 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 983545003400 Found in ATP-dependent protease La (LON); Region: LON; cl01056 983545003401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545003402 Walker A motif; other site 983545003403 ATP binding site [chemical binding]; other site 983545003404 Walker B motif; other site 983545003405 arginine finger; other site 983545003406 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 983545003407 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 983545003408 IHF dimer interface [polypeptide binding]; other site 983545003409 IHF - DNA interface [nucleotide binding]; other site 983545003410 periplasmic folding chaperone; Provisional; Region: PRK10788 983545003411 SurA N-terminal domain; Region: SurA_N; pfam09312 983545003412 PPIC-type PPIASE domain; Region: Rotamase; cl08278 983545003413 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 983545003414 active site 983545003415 multimer interface [polypeptide binding]; other site 983545003416 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 983545003417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 983545003418 FeS/SAM binding site; other site 983545003419 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 983545003420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545003421 binding surface 983545003422 TPR motif; other site 983545003423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545003424 TPR motif; other site 983545003425 binding surface 983545003426 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545003427 putative peptidoglycan binding site; other site 983545003428 cytoskeletal protein RodZ; Provisional; Region: PRK10856 983545003429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545003430 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 983545003431 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 983545003432 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 983545003433 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 983545003434 dimer interface [polypeptide binding]; other site 983545003435 motif 1; other site 983545003436 active site 983545003437 motif 2; other site 983545003438 motif 3; other site 983545003439 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 983545003440 anticodon binding site; other site 983545003441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 983545003442 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 983545003443 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 983545003444 GTP-binding protein Der; Reviewed; Region: PRK00093 983545003445 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 983545003446 G1 box; other site 983545003447 GTP/Mg2+ binding site [chemical binding]; other site 983545003448 Switch I region; other site 983545003449 G2 box; other site 983545003450 Switch II region; other site 983545003451 G3 box; other site 983545003452 G4 box; other site 983545003453 G5 box; other site 983545003454 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 983545003455 G1 box; other site 983545003456 GTP/Mg2+ binding site [chemical binding]; other site 983545003457 Switch I region; other site 983545003458 G2 box; other site 983545003459 G3 box; other site 983545003460 Switch II region; other site 983545003461 G4 box; other site 983545003462 G5 box; other site 983545003463 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 983545003464 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 983545003465 generic binding surface II; other site 983545003466 generic binding surface I; other site 983545003467 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 983545003468 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 983545003469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 983545003470 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 983545003471 active site 983545003472 GMP synthase; Reviewed; Region: guaA; PRK00074 983545003473 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 983545003474 AMP/PPi binding site [chemical binding]; other site 983545003475 candidate oxyanion hole; other site 983545003476 catalytic triad [active] 983545003477 potential glutamine specificity residues [chemical binding]; other site 983545003478 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 983545003479 ATP Binding subdomain [chemical binding]; other site 983545003480 Ligand Binding sites [chemical binding]; other site 983545003481 Dimerization subdomain; other site 983545003482 YaeQ protein; Region: YaeQ; cl01913 983545003483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545003484 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 983545003485 nucleoside/Zn binding site; other site 983545003486 dimer interface [polypeptide binding]; other site 983545003487 catalytic motif [active] 983545003488 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 983545003489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 983545003490 substrate binding pocket [chemical binding]; other site 983545003491 membrane-bound complex binding site; other site 983545003492 hinge residues; other site 983545003493 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545003494 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545003495 catalytic residue [active] 983545003496 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 983545003497 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 983545003498 dimerization interface [polypeptide binding]; other site 983545003499 ATP binding site [chemical binding]; other site 983545003500 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 983545003501 dimerization interface [polypeptide binding]; other site 983545003502 ATP binding site [chemical binding]; other site 983545003503 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 983545003504 putative active site [active] 983545003505 catalytic triad [active] 983545003506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 983545003507 Smr domain; Region: Smr; cl02619 983545003508 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 983545003509 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 983545003510 active site 983545003511 Zn binding site [ion binding]; other site 983545003512 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 983545003513 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545003514 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 983545003515 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545003516 N-terminal plug; other site 983545003517 ligand-binding site [chemical binding]; other site 983545003518 Protein of unknown function, DUF400; Region: DUF400; cl01141 983545003519 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 983545003520 SAF domain; Region: SAF; cl00555 983545003521 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 983545003522 Response regulator receiver domain; Region: Response_reg; pfam00072 983545003523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545003524 active site 983545003525 phosphorylation site [posttranslational modification] 983545003526 intermolecular recognition site; other site 983545003527 dimerization interface [polypeptide binding]; other site 983545003528 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 983545003529 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 983545003530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545003531 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 983545003532 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 983545003533 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 983545003534 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 983545003535 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 983545003536 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 983545003537 Flagellar hook capping protein; Region: FlgD; cl04347 983545003538 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 983545003539 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 983545003540 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 983545003541 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 983545003542 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 983545003543 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 983545003544 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 983545003545 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 983545003546 Flagellar L-ring protein; Region: FlgH; cl00905 983545003547 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 983545003548 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 983545003549 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 983545003550 Rod binding protein; Region: Rod-binding; cl01626 983545003551 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 983545003552 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683 983545003553 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 983545003554 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 983545003555 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003556 flagellin; Provisional; Region: PRK12802 983545003557 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003558 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003559 flagellin; Provisional; Region: PRK12802 983545003560 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003561 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003562 flagellin; Provisional; Region: PRK12802 983545003563 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003564 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 983545003565 FlaG protein; Region: FlaG; cl00591 983545003566 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 983545003567 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 983545003568 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 983545003569 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 983545003570 Flagellar protein FliS; Region: FliS; cl00654 983545003571 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 983545003572 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 983545003573 NAD(P) binding site [chemical binding]; other site 983545003574 homodimer interface [polypeptide binding]; other site 983545003575 substrate binding site [chemical binding]; other site 983545003576 active site 983545003577 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 983545003578 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 983545003579 inhibitor-cofactor binding pocket; inhibition site 983545003580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545003581 catalytic residue [active] 983545003582 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003583 ligand binding site [chemical binding]; other site 983545003584 tetramer interface [polypeptide binding]; other site 983545003585 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545003586 pseudaminic acid synthase; Region: PseI; TIGR03586 983545003587 NeuB family; Region: NeuB; cl00496 983545003588 SAF domain; Region: SAF; cl00555 983545003589 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 983545003590 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545003591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545003592 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545003593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545003594 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545003595 NAD(P) binding site [chemical binding]; other site 983545003596 active site 983545003597 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 983545003598 LicD family; Region: LicD; cl01378 983545003599 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545003600 active site 983545003601 nucleotide binding site [chemical binding]; other site 983545003602 HIGH motif; other site 983545003603 KMSKS motif; other site 983545003604 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 983545003605 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983545003606 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545003607 active site 983545003608 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 983545003609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545003610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545003611 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 983545003612 ligand binding site [chemical binding]; other site 983545003613 tetramer interface [polypeptide binding]; other site 983545003614 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 983545003615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 983545003616 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 983545003617 NeuB family; Region: NeuB; cl00496 983545003618 SAF domain; Region: SAF; cl00555 983545003619 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 983545003620 Metal-binding active site; metal-binding site 983545003621 AP (apurinic/apyrimidinic) site pocket; other site 983545003622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 983545003623 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 983545003624 flagellin; Reviewed; Region: PRK08869 983545003625 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545003626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 983545003627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545003628 Walker A motif; other site 983545003629 ATP binding site [chemical binding]; other site 983545003630 Walker B motif; other site 983545003631 arginine finger; other site 983545003632 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 983545003633 sensory histidine kinase AtoS; Provisional; Region: PRK11360 983545003634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545003635 dimer interface [polypeptide binding]; other site 983545003636 phosphorylation site [posttranslational modification] 983545003637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003638 ATP binding site [chemical binding]; other site 983545003639 Mg2+ binding site [ion binding]; other site 983545003640 G-X-G motif; other site 983545003641 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545003642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545003643 active site 983545003644 phosphorylation site [posttranslational modification] 983545003645 intermolecular recognition site; other site 983545003646 dimerization interface [polypeptide binding]; other site 983545003647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545003648 Walker A motif; other site 983545003649 ATP binding site [chemical binding]; other site 983545003650 Walker B motif; other site 983545003651 arginine finger; other site 983545003652 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 983545003653 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 983545003654 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 983545003655 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 983545003656 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 983545003657 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 983545003658 FliG C-terminal domain; Region: FliG_C; pfam01706 983545003659 flagellar assembly protein H; Validated; Region: fliH; PRK05687 983545003660 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 983545003661 Flagellar assembly protein FliH; Region: FliH; pfam02108 983545003662 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 983545003663 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 983545003664 Walker A motif/ATP binding site; other site 983545003665 Walker B motif; other site 983545003666 Flagellar FliJ protein; Region: FliJ; cl09161 983545003667 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 983545003668 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 983545003669 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 983545003670 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 983545003671 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 983545003672 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 983545003673 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 983545003674 FliP family; Region: FliP; cl00593 983545003675 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 983545003676 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 983545003677 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 983545003678 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 983545003679 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 983545003680 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 983545003681 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 983545003682 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545003683 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 983545003684 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545003685 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 983545003686 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 983545003687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545003688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 983545003689 DNA binding residues [nucleotide binding] 983545003690 Response regulator receiver domain; Region: Response_reg; pfam00072 983545003691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545003692 active site 983545003693 phosphorylation site [posttranslational modification] 983545003694 intermolecular recognition site; other site 983545003695 dimerization interface [polypeptide binding]; other site 983545003696 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 983545003697 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545003698 putative binding surface; other site 983545003699 active site 983545003700 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 983545003701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003702 ATP binding site [chemical binding]; other site 983545003703 Mg2+ binding site [ion binding]; other site 983545003704 G-X-G motif; other site 983545003705 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 983545003706 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 983545003707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545003708 active site 983545003709 phosphorylation site [posttranslational modification] 983545003710 intermolecular recognition site; other site 983545003711 dimerization interface [polypeptide binding]; other site 983545003712 CheB methylesterase; Region: CheB_methylest; pfam01339 983545003713 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 983545003714 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 983545003715 Magnesium ion binding site [ion binding]; other site 983545003716 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 983545003717 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 983545003718 putative CheA interaction surface; other site 983545003719 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 983545003720 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 983545003721 proposed active site lysine [active] 983545003722 conserved cys residue [active] 983545003723 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 983545003724 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 983545003725 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 983545003726 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 983545003727 substrate binding pocket [chemical binding]; other site 983545003728 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 983545003729 B12 binding site [chemical binding]; other site 983545003730 cobalt ligand [ion binding]; other site 983545003731 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 983545003732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545003733 FemAB family; Region: FemAB; cl11444 983545003734 Protein of unknown function, DUF482; Region: DUF482; pfam04339 983545003735 RecX family; Region: RecX; cl00936 983545003736 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 983545003737 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 983545003738 motif 1; other site 983545003739 active site 983545003740 motif 2; other site 983545003741 motif 3; other site 983545003742 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 983545003743 DHHA1 domain; Region: DHHA1; pfam02272 983545003744 Global regulator protein family; Region: CsrA; cl00670 983545003745 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 983545003746 oxaloacetate decarboxylase; Provisional; Region: PRK14040 983545003747 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 983545003748 active site 983545003749 catalytic residues [active] 983545003750 metal binding site [ion binding]; metal-binding site 983545003751 homodimer binding site [polypeptide binding]; other site 983545003752 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 983545003753 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 983545003754 carboxyltransferase (CT) interaction site; other site 983545003755 biotinylation site [posttranslational modification]; other site 983545003756 subunit; Region: OAD_beta; cl00816 983545003757 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 983545003758 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 983545003759 Walker A/P-loop; other site 983545003760 ATP binding site [chemical binding]; other site 983545003761 Q-loop/lid; other site 983545003762 ABC transporter signature motif; other site 983545003763 Walker B; other site 983545003764 D-loop; other site 983545003765 H-loop/switch region; other site 983545003766 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 983545003767 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 983545003768 Walker A/P-loop; other site 983545003769 ATP binding site [chemical binding]; other site 983545003770 Q-loop/lid; other site 983545003771 ABC transporter signature motif; other site 983545003772 Walker B; other site 983545003773 D-loop; other site 983545003774 H-loop/switch region; other site 983545003775 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 983545003776 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 983545003777 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 983545003778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545003779 dimer interface [polypeptide binding]; other site 983545003780 conserved gate region; other site 983545003781 putative PBP binding loops; other site 983545003782 ABC-ATPase subunit interface; other site 983545003783 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 983545003784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545003785 dimer interface [polypeptide binding]; other site 983545003786 conserved gate region; other site 983545003787 putative PBP binding loops; other site 983545003788 ABC-ATPase subunit interface; other site 983545003789 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 983545003790 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 983545003791 peptide binding site [polypeptide binding]; other site 983545003792 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 983545003793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545003794 Walker A motif; other site 983545003795 ATP binding site [chemical binding]; other site 983545003796 Walker B motif; other site 983545003797 arginine finger; other site 983545003798 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 983545003799 phage shock protein PspA; Provisional; Region: PRK10698 983545003800 Phage shock protein B; Region: PspB; cl05946 983545003801 phage shock protein C; Region: phageshock_pspC; TIGR02978 983545003802 PspC domain; Region: PspC; cl00864 983545003803 YcjX-like family, DUF463; Region: DUF463; cl01193 983545003804 hypothetical protein; Provisional; Region: PRK05415 983545003805 Domain of unknown function (DUF697); Region: DUF697; cl12064 983545003806 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH)...; Region: pro_PheOH; cd03348 983545003807 cofactor binding site; other site 983545003808 metal binding site [ion binding]; metal-binding site 983545003809 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 983545003810 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 983545003811 putative aromatic amino acid binding site; other site 983545003812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545003813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545003814 Walker A motif; other site 983545003815 ATP binding site [chemical binding]; other site 983545003816 Walker B motif; other site 983545003817 arginine finger; other site 983545003818 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 983545003819 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 983545003820 dimer interface [polypeptide binding]; other site 983545003821 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 983545003822 active site 983545003823 Fe binding site [ion binding]; other site 983545003824 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545003825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545003826 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 983545003827 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983545003828 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 983545003829 NAD binding site [chemical binding]; other site 983545003830 Phe binding site; other site 983545003831 Late competence development protein ComFB; Region: ComFB; pfam10719 983545003832 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545003833 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545003834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545003835 binding surface 983545003836 TPR motif; other site 983545003837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545003838 binding surface 983545003839 TPR motif; other site 983545003840 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 983545003841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545003842 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 983545003843 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 983545003844 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545003845 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545003846 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545003847 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545003848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545003849 binding surface 983545003850 TPR motif; other site 983545003851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545003852 binding surface 983545003853 TPR motif; other site 983545003854 putative chaperone; Provisional; Region: PRK11678 983545003855 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 983545003856 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545003857 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 983545003858 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545003859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545003860 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545003861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545003862 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545003863 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 983545003864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545003865 catalytic residue [active] 983545003866 endonuclease III; Provisional; Region: PRK10702 983545003867 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 983545003868 minor groove reading motif; other site 983545003869 helix-hairpin-helix signature motif; other site 983545003870 substrate binding pocket [chemical binding]; other site 983545003871 active site 983545003872 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 983545003873 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 983545003874 FMN-binding domain; Region: FMN_bind; cl01081 983545003875 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 983545003876 C subunit; Region: rnfC; TIGR01945 983545003877 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 983545003878 SLBB domain; Region: SLBB; pfam10531 983545003879 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 983545003880 electron transport complex protein RnfB; Provisional; Region: PRK05113 983545003881 Putative Fe-S cluster; Region: FeS; pfam04060 983545003882 4Fe-4S binding domain; Region: Fer4; cl02805 983545003883 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 983545003884 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 983545003885 MatE; Region: MatE; pfam01554 983545003886 MatE; Region: MatE; pfam01554 983545003887 excinuclease ABC subunit B; Provisional; Region: PRK05298 983545003888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545003889 ATP binding site [chemical binding]; other site 983545003890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545003891 nucleotide binding region [chemical binding]; other site 983545003892 ATP-binding site [chemical binding]; other site 983545003893 Ultra-violet resistance protein B; Region: UvrB; pfam12344 983545003894 UvrB/uvrC motif; Region: UVR; pfam02151 983545003895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545003896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545003897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545003898 dimerization interface [polypeptide binding]; other site 983545003899 MASE1; Region: MASE1; pfam05231 983545003900 CHASE domain; Region: CHASE; cl01369 983545003901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545003902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545003903 dimer interface [polypeptide binding]; other site 983545003904 phosphorylation site [posttranslational modification] 983545003905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545003906 ATP binding site [chemical binding]; other site 983545003907 Mg2+ binding site [ion binding]; other site 983545003908 G-X-G motif; other site 983545003909 Response regulator receiver domain; Region: Response_reg; pfam00072 983545003910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545003911 active site 983545003912 phosphorylation site [posttranslational modification] 983545003913 intermolecular recognition site; other site 983545003914 dimerization interface [polypeptide binding]; other site 983545003915 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 983545003916 Ligand Binding Site [chemical binding]; other site 983545003917 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 983545003918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 983545003919 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545003920 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 983545003921 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 983545003922 NADP binding site [chemical binding]; other site 983545003923 dimer interface [polypeptide binding]; other site 983545003924 hypothetical protein; Provisional; Region: PRK06194 983545003925 classical (c) SDRs; Region: SDR_c; cd05233 983545003926 NAD(P) binding site [chemical binding]; other site 983545003927 active site 983545003928 asparagine synthetase B; Provisional; Region: asnB; PRK09431 983545003929 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545003930 active site 983545003931 dimer interface [polypeptide binding]; other site 983545003932 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 983545003933 Ligand Binding Site [chemical binding]; other site 983545003934 Molecular Tunnel; other site 983545003935 M28, and M42; Region: Zinc_peptidase_like; cl14876 983545003936 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-...; Region: PA_M28_1_2; cd04821 983545003937 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 983545003938 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545003939 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 983545003940 metal binding site [ion binding]; metal-binding site 983545003941 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 983545003942 Yip1 domain; Region: Yip1; cl12048 983545003943 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 983545003944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545003945 Walker A/P-loop; other site 983545003946 ATP binding site [chemical binding]; other site 983545003947 Q-loop/lid; other site 983545003948 ABC transporter signature motif; other site 983545003949 Walker B; other site 983545003950 D-loop; other site 983545003951 H-loop/switch region; other site 983545003952 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 983545003953 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545003954 Protein of unknown function DUF72; Region: DUF72; cl00777 983545003955 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 983545003956 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 983545003957 dimer interface [polypeptide binding]; other site 983545003958 anticodon binding site; other site 983545003959 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 983545003960 homodimer interface [polypeptide binding]; other site 983545003961 motif 1; other site 983545003962 active site 983545003963 motif 2; other site 983545003964 GAD domain; Region: GAD; pfam02938 983545003965 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983545003966 active site 983545003967 motif 3; other site 983545003968 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 983545003969 nudix motif; other site 983545003970 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 983545003971 active site 983545003972 putative DNA-binding cleft [nucleotide binding]; other site 983545003973 dimer interface [polypeptide binding]; other site 983545003974 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 983545003975 RuvA N terminal domain; Region: RuvA_N; pfam01330 983545003976 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 983545003977 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 983545003978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545003979 Walker A motif; other site 983545003980 ATP binding site [chemical binding]; other site 983545003981 Walker B motif; other site 983545003982 arginine finger; other site 983545003983 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 983545003984 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 983545003985 active site 983545003986 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545003987 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545003988 TolA C-terminal; Region: TolA; pfam06519 983545003989 translocation protein TolB; Provisional; Region: tolB; PRK04792 983545003990 TolB amino-terminal domain; Region: TolB_N; pfam04052 983545003991 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545003992 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545003993 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 983545003994 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545003995 ligand binding site [chemical binding]; other site 983545003996 tol-pal system protein YbgF; Provisional; Region: PRK10803 983545003997 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545003998 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 983545003999 active site 983545004000 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545004001 active site 2 [active] 983545004002 active site 1 [active] 983545004003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545004004 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545004005 putative substrate translocation pore; other site 983545004006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004007 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004008 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 983545004009 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 983545004010 ligand binding site [chemical binding]; other site 983545004011 oligomer interface [polypeptide binding]; other site 983545004012 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 983545004013 dimer interface [polypeptide binding]; other site 983545004014 N-terminal domain interface [polypeptide binding]; other site 983545004015 sulfate 1 binding site; other site 983545004016 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 983545004017 putative hydrophobic ligand binding site [chemical binding]; other site 983545004018 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 983545004019 active site 983545004020 catalytic residues [active] 983545004021 metal binding site [ion binding]; metal-binding site 983545004022 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 983545004023 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545004024 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545004025 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 983545004026 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 983545004027 carboxyltransferase (CT) interaction site; other site 983545004028 biotinylation site [posttranslational modification]; other site 983545004029 enoyl-CoA hydratase; Provisional; Region: PRK05995 983545004030 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545004031 substrate binding site [chemical binding]; other site 983545004032 oxyanion hole (OAH) forming residues; other site 983545004033 trimer interface [polypeptide binding]; other site 983545004034 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 983545004035 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 983545004036 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 983545004037 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 983545004038 isovaleryl-CoA dehydrogenase; Region: PLN02519 983545004039 substrate binding site [chemical binding]; other site 983545004040 FAD binding site [chemical binding]; other site 983545004041 catalytic base [active] 983545004042 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 983545004043 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 983545004044 DNA binding residues [nucleotide binding] 983545004045 putative dimer interface [polypeptide binding]; other site 983545004046 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 983545004047 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545004048 dimer interface [polypeptide binding]; other site 983545004049 active site 983545004050 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 983545004051 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004052 kynureninase; Region: kynureninase; TIGR01814 983545004053 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545004054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545004055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004056 catalytic residue [active] 983545004057 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545004058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545004059 active site 983545004060 phosphorylation site [posttranslational modification] 983545004061 intermolecular recognition site; other site 983545004062 dimerization interface [polypeptide binding]; other site 983545004063 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 983545004064 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 983545004065 HIGH motif; other site 983545004066 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 983545004067 active site 983545004068 KMSKS motif; other site 983545004069 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 983545004070 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 983545004071 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 983545004072 FMN binding site [chemical binding]; other site 983545004073 active site 983545004074 catalytic residues [active] 983545004075 substrate binding site [chemical binding]; other site 983545004076 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 983545004077 active site 983545004078 catalytic triad [active] 983545004079 oxyanion hole [active] 983545004080 switch loop; other site 983545004081 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 983545004082 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545004083 Walker A/P-loop; other site 983545004084 ATP binding site [chemical binding]; other site 983545004085 Q-loop/lid; other site 983545004086 ABC transporter signature motif; other site 983545004087 Walker B; other site 983545004088 D-loop; other site 983545004089 H-loop/switch region; other site 983545004090 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 983545004091 FtsX-like permease family; Region: FtsX; pfam02687 983545004092 FtsX-like permease family; Region: FtsX; pfam02687 983545004093 TIGR01777 family protein; Region: yfcH 983545004094 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 983545004095 putative NAD(P) binding site [chemical binding]; other site 983545004096 putative active site [active] 983545004097 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 983545004098 active site 983545004099 Domain of unknown function DUF20; Region: UPF0118; cl00465 983545004100 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 983545004101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004102 NAD(P) binding site [chemical binding]; other site 983545004103 active site 983545004104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004106 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545004107 putative effector binding pocket; other site 983545004108 dimerization interface [polypeptide binding]; other site 983545004109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004110 metal binding site [ion binding]; metal-binding site 983545004111 active site 983545004112 I-site; other site 983545004113 hypothetical protein; Provisional; Region: PRK05409 983545004114 Protein of unknown function (DUF692); Region: DUF692; cl01263 983545004115 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 983545004116 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 983545004117 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 983545004118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545004119 Walker A motif; other site 983545004120 ATP binding site [chemical binding]; other site 983545004121 Walker B motif; other site 983545004122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545004123 arginine finger; other site 983545004124 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 983545004125 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 983545004126 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 983545004127 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 983545004128 recombination protein RecR; Reviewed; Region: recR; PRK00076 983545004129 RecR protein; Region: RecR; pfam02132 983545004130 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 983545004131 putative active site [active] 983545004132 putative metal-binding site [ion binding]; other site 983545004133 tetramer interface [polypeptide binding]; other site 983545004134 heat shock protein 90; Provisional; Region: PRK05218 983545004135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545004136 ATP binding site [chemical binding]; other site 983545004137 Mg2+ binding site [ion binding]; other site 983545004138 G-X-G motif; other site 983545004139 adenylate kinase; Reviewed; Region: adk; PRK00279 983545004140 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 983545004141 AMP-binding site [chemical binding]; other site 983545004142 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 983545004143 MAPEG family; Region: MAPEG; cl09190 983545004144 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 983545004145 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 983545004146 putative dimer interface [polypeptide binding]; other site 983545004147 YceI-like domain; Region: YceI; cl01001 983545004148 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 983545004149 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 983545004150 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 983545004151 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 983545004152 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 983545004153 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 983545004154 substrate binding site [chemical binding]; other site 983545004155 glutamase interaction surface [polypeptide binding]; other site 983545004156 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 983545004157 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 983545004158 homodimer interface [polypeptide binding]; other site 983545004159 substrate-cofactor binding pocket; other site 983545004160 catalytic residue [active] 983545004161 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 983545004162 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 983545004163 catalytic residues [active] 983545004164 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 983545004165 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 983545004166 putative active site [active] 983545004167 oxyanion strand; other site 983545004168 catalytic triad [active] 983545004169 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 983545004170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545004171 active site 983545004172 motif I; other site 983545004173 motif II; other site 983545004174 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 983545004175 putative active site pocket [active] 983545004176 4-fold oligomerization interface [polypeptide binding]; other site 983545004177 metal binding residues [ion binding]; metal-binding site 983545004178 3-fold/trimer interface [polypeptide binding]; other site 983545004179 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 983545004180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545004181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545004182 homodimer interface [polypeptide binding]; other site 983545004183 catalytic residue [active] 983545004184 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 983545004185 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 983545004186 NAD binding site [chemical binding]; other site 983545004187 dimerization interface [polypeptide binding]; other site 983545004188 product binding site; other site 983545004189 substrate binding site [chemical binding]; other site 983545004190 zinc binding site [ion binding]; other site 983545004191 catalytic residues [active] 983545004192 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 983545004193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004194 HisG, C-terminal domain; Region: HisG_C; cl06867 983545004195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 983545004196 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545004197 active site 983545004198 catalytic tetrad [active] 983545004199 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 983545004200 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 983545004201 sulfite oxidase; Provisional; Region: PLN00177 983545004202 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 983545004203 Moco binding site; other site 983545004204 metal coordination site [ion binding]; other site 983545004205 dimerization interface [polypeptide binding]; other site 983545004206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545004207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545004208 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545004209 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545004210 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 983545004211 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545004212 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545004213 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545004214 DNA binding residues [nucleotide binding] 983545004215 dimer interface [polypeptide binding]; other site 983545004216 putative metal binding site [ion binding]; other site 983545004217 Cation efflux family; Region: Cation_efflux; cl00316 983545004218 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 983545004219 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004220 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004221 ligand-binding site [chemical binding]; other site 983545004222 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 983545004223 DctM-like transporters; Region: DctM; pfam06808 983545004224 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545004225 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 983545004226 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 983545004227 active site 983545004228 homotrimer interface [polypeptide binding]; other site 983545004229 catalytic site [active] 983545004230 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 983545004231 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 983545004232 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004233 metal binding site [ion binding]; metal-binding site 983545004234 active site 983545004235 I-site; other site 983545004236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545004237 ACT domain; Region: ACT_3; cl01447 983545004238 Uncharacterized conserved protein [Function unknown]; Region: COG3603 983545004239 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545004240 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545004241 substrate binding site [chemical binding]; other site 983545004242 oxyanion hole (OAH) forming residues; other site 983545004243 trimer interface [polypeptide binding]; other site 983545004244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004245 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 983545004246 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 983545004247 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 983545004248 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545004249 Cytochrome c; Region: Cytochrom_C; cl11414 983545004250 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545004251 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 983545004252 D-pathway; other site 983545004253 Putative ubiquinol binding site [chemical binding]; other site 983545004254 Low-spin heme (heme b) binding site [chemical binding]; other site 983545004255 Putative water exit pathway; other site 983545004256 Binuclear center (heme o3/CuB) [ion binding]; other site 983545004257 K-pathway; other site 983545004258 Putative proton exit pathway; other site 983545004259 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 983545004260 Subunit I/III interface [polypeptide binding]; other site 983545004261 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 983545004262 Cytochrome c; Region: Cytochrom_C; cl11414 983545004263 Cytochrome c; Region: Cytochrom_C; cl11414 983545004264 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 983545004265 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545004266 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545004267 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 983545004268 Peptidase family M48; Region: Peptidase_M48; cl12018 983545004269 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 983545004270 homotrimer interaction site [polypeptide binding]; other site 983545004271 putative active site [active] 983545004272 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545004273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004274 catalytic residue [active] 983545004275 2-isopropylmalate synthase; Validated; Region: PRK03739 983545004276 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 983545004277 active site 983545004278 catalytic residues [active] 983545004279 metal binding site [ion binding]; metal-binding site 983545004280 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 983545004281 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545004282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004283 LysE type translocator; Region: LysE; cl00565 983545004284 LysR family transcriptional regulator; Provisional; Region: PRK14997 983545004285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004287 dimerization interface [polypeptide binding]; other site 983545004288 Pirin-related protein [General function prediction only]; Region: COG1741 983545004289 Cupin domain; Region: Cupin_2; cl09118 983545004290 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 983545004291 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 983545004292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004293 NAD(P) binding site [chemical binding]; other site 983545004294 active site 983545004295 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 983545004296 Cupin domain; Region: Cupin_2; cl09118 983545004297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004298 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545004299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545004300 Beta-lactamase; Region: Beta-lactamase; cl01009 983545004301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545004302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545004303 non-specific DNA binding site [nucleotide binding]; other site 983545004304 salt bridge; other site 983545004305 sequence-specific DNA binding site [nucleotide binding]; other site 983545004306 aspartate aminotransferase; Provisional; Region: PRK08361 983545004307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545004308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545004309 homodimer interface [polypeptide binding]; other site 983545004310 catalytic residue [active] 983545004311 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983545004312 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004313 N-terminal plug; other site 983545004314 ligand-binding site [chemical binding]; other site 983545004315 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 983545004316 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 983545004317 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 983545004318 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 983545004319 intersubunit interface [polypeptide binding]; other site 983545004320 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 983545004321 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 983545004322 ABC-ATPase subunit interface; other site 983545004323 dimer interface [polypeptide binding]; other site 983545004324 putative PBP binding regions; other site 983545004325 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 983545004326 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 983545004327 Walker A/P-loop; other site 983545004328 ATP binding site [chemical binding]; other site 983545004329 Q-loop/lid; other site 983545004330 ABC transporter signature motif; other site 983545004331 Walker B; other site 983545004332 D-loop; other site 983545004333 H-loop/switch region; other site 983545004334 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 983545004335 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545004336 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 983545004337 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 983545004338 catalytic residues [active] 983545004339 Ion channel; Region: Ion_trans_2; cl11596 983545004340 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004341 metal binding site [ion binding]; metal-binding site 983545004342 active site 983545004343 I-site; other site 983545004344 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 983545004345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545004346 Coenzyme A binding pocket [chemical binding]; other site 983545004347 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 983545004348 REJ domain; Region: REJ; pfam02010 983545004349 REJ domain; Region: REJ; pfam02010 983545004350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545004351 binding surface 983545004352 TPR motif; other site 983545004353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545004354 binding surface 983545004355 TPR motif; other site 983545004356 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 983545004357 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 983545004358 putative active site [active] 983545004359 catalytic triad [active] 983545004360 putative dimer interface [polypeptide binding]; other site 983545004361 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545004362 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 983545004363 NAD(P) binding site [chemical binding]; other site 983545004364 catalytic residues [active] 983545004365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545004366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545004367 putative substrate translocation pore; other site 983545004368 YCII-related domain; Region: YCII; cl00999 983545004369 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545004370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004371 DNA-binding site [nucleotide binding]; DNA binding site 983545004372 UTRA domain; Region: UTRA; cl06649 983545004373 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 983545004374 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 983545004375 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545004376 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 983545004377 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 983545004378 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545004379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004380 DNA-binding site [nucleotide binding]; DNA binding site 983545004381 UTRA domain; Region: UTRA; cl06649 983545004382 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545004383 FAD binding domain; Region: FAD_binding_4; pfam01565 983545004384 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004385 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 983545004386 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 983545004387 substrate binding site [chemical binding]; other site 983545004388 ligand binding site [chemical binding]; other site 983545004389 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 983545004390 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 983545004391 substrate binding site [chemical binding]; other site 983545004392 CoA-transferase family III; Region: CoA_transf_3; cl00778 983545004393 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 983545004394 active site 983545004395 catalytic residues [active] 983545004396 metal binding site [ion binding]; metal-binding site 983545004397 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 983545004398 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 983545004399 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545004400 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 983545004401 N-terminal domain interface [polypeptide binding]; other site 983545004402 dimer interface [polypeptide binding]; other site 983545004403 substrate binding pocket (H-site) [chemical binding]; other site 983545004404 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545004405 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545004406 NAD(P) binding site [chemical binding]; other site 983545004407 substrate binding site [chemical binding]; other site 983545004408 dimer interface [polypeptide binding]; other site 983545004409 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 983545004410 dockerin binding interface; other site 983545004411 PEP-CTERM motif; Region: VPEP; pfam07589 983545004412 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004413 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004414 N-terminal plug; other site 983545004415 ligand-binding site [chemical binding]; other site 983545004416 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545004418 enoyl-CoA hydratase; Provisional; Region: PRK06127 983545004419 substrate binding site [chemical binding]; other site 983545004420 oxyanion hole (OAH) forming residues; other site 983545004421 trimer interface [polypeptide binding]; other site 983545004422 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545004423 CoenzymeA binding site [chemical binding]; other site 983545004424 subunit interaction site [polypeptide binding]; other site 983545004425 PHB binding site; other site 983545004426 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 983545004427 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 983545004428 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545004429 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 983545004430 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545004431 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 983545004432 Isochorismatase family; Region: Isochorismatase; pfam00857 983545004433 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 983545004434 catalytic triad [active] 983545004435 conserved cis-peptide bond; other site 983545004436 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 983545004437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545004438 S-adenosylmethionine binding site [chemical binding]; other site 983545004439 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545004440 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545004441 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 983545004442 putative acyl-acceptor binding pocket; other site 983545004443 REDY-like protein HapK; Region: HapK; pfam11639 983545004444 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545004445 classical (c) SDRs; Region: SDR_c; cd05233 983545004446 NAD(P) binding site [chemical binding]; other site 983545004447 active site 983545004448 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545004449 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 983545004450 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545004451 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 983545004452 putative active site [active] 983545004453 putative catalytic site [active] 983545004454 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545004455 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545004456 active site 983545004457 CoA-transferase family III; Region: CoA_transf_3; cl00778 983545004458 CoA-transferase family III; Region: CoA_transf_3; cl00778 983545004459 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 983545004460 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004461 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004462 N-terminal plug; other site 983545004463 ligand-binding site [chemical binding]; other site 983545004464 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545004465 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 983545004466 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 983545004467 EthD protein; Region: EthD; cl06234 983545004468 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 983545004469 CoenzymeA binding site [chemical binding]; other site 983545004470 subunit interaction site [polypeptide binding]; other site 983545004471 PHB binding site; other site 983545004472 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004473 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545004474 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004475 Predicted ATPase [General function prediction only]; Region: COG1485 983545004476 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545004477 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004478 N-terminal plug; other site 983545004479 ligand-binding site [chemical binding]; other site 983545004480 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545004481 active site 983545004482 metal binding site [ion binding]; metal-binding site 983545004483 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 983545004484 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545004485 ligand binding site [chemical binding]; other site 983545004486 flexible hinge region; other site 983545004487 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 983545004488 putative switch regulator; other site 983545004489 non-specific DNA interactions [nucleotide binding]; other site 983545004490 DNA binding site [nucleotide binding] 983545004491 sequence specific DNA binding site [nucleotide binding]; other site 983545004492 putative cAMP binding site [chemical binding]; other site 983545004493 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545004494 active site 983545004495 metal binding site [ion binding]; metal-binding site 983545004496 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545004497 active site 983545004498 metal binding site [ion binding]; metal-binding site 983545004499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545004500 Coenzyme A binding pocket [chemical binding]; other site 983545004501 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545004502 Sulfatase; Region: Sulfatase; cl10460 983545004503 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545004504 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545004505 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545004506 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545004507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004508 DNA-binding site [nucleotide binding]; DNA binding site 983545004509 FCD domain; Region: FCD; cl11656 983545004510 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545004511 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545004512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004513 DNA binding site [nucleotide binding] 983545004514 domain linker motif; other site 983545004515 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545004516 dimerization interface [polypeptide binding]; other site 983545004517 ligand binding site [chemical binding]; other site 983545004518 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545004519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004520 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545004521 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 983545004522 AP (apurinic/apyrimidinic) site pocket; other site 983545004523 DNA interaction; other site 983545004524 Metal-binding active site; metal-binding site 983545004525 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 983545004526 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 983545004527 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 983545004528 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 983545004529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545004530 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545004531 glycerol kinase; Region: glycerol_kin; TIGR01311 983545004532 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 983545004533 putative transporter; Provisional; Region: PRK10484 983545004534 Sodium:solute symporter family; Region: SSF; cl00456 983545004535 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 983545004536 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 983545004537 active site 983545004538 catalytic residues [active] 983545004539 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 983545004540 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004541 DNA binding site [nucleotide binding] 983545004542 domain linker motif; other site 983545004543 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545004544 dimerization interface (closed form) [polypeptide binding]; other site 983545004545 ligand binding site [chemical binding]; other site 983545004546 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 983545004547 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 983545004548 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545004549 DNA binding site [nucleotide binding] 983545004550 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545004551 dimerization interface (closed form) [polypeptide binding]; other site 983545004552 ligand binding site [chemical binding]; other site 983545004553 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545004554 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 983545004555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004556 catalytic residue [active] 983545004557 Bacterial protein of unknown function (DUF920); Region: DUF920; cl01479 983545004558 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545004559 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004560 metal binding site [ion binding]; metal-binding site 983545004561 active site 983545004562 I-site; other site 983545004563 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545004564 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 983545004565 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 983545004566 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 983545004567 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545004568 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 983545004569 Walker A/P-loop; other site 983545004570 ATP binding site [chemical binding]; other site 983545004571 Q-loop/lid; other site 983545004572 ABC transporter signature motif; other site 983545004573 Walker B; other site 983545004574 D-loop; other site 983545004575 H-loop/switch region; other site 983545004576 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 983545004577 Outer membrane efflux protein; Region: OEP; pfam02321 983545004578 Outer membrane efflux protein; Region: OEP; pfam02321 983545004579 Protein of unknown function (DUF3607); Region: DUF3607; pfam12245 983545004580 Protein of unknown function (DUF3607); Region: DUF3607; pfam12245 983545004581 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 983545004582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 983545004585 dimerization interface [polypeptide binding]; other site 983545004586 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545004587 active site 983545004588 metal binding site [ion binding]; metal-binding site 983545004589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004591 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545004592 putative effector binding pocket; other site 983545004593 dimerization interface [polypeptide binding]; other site 983545004594 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 983545004595 potential catalytic triad [active] 983545004596 conserved cys residue [active] 983545004597 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 983545004598 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 983545004599 putative phosphate binding site [ion binding]; other site 983545004600 putative catalytic site [active] 983545004601 active site 983545004602 metal binding site A [ion binding]; metal-binding site 983545004603 DNA binding site [nucleotide binding] 983545004604 putative AP binding site [nucleotide binding]; other site 983545004605 putative metal binding site B [ion binding]; other site 983545004606 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545004607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545004608 DNA-binding site [nucleotide binding]; DNA binding site 983545004609 FCD domain; Region: FCD; cl11656 983545004610 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 983545004611 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 983545004612 active site pocket [active] 983545004613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545004614 D-galactonate transporter; Region: 2A0114; TIGR00893 983545004615 putative substrate translocation pore; other site 983545004616 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545004617 substrate binding site [chemical binding]; other site 983545004618 ATP binding site [chemical binding]; other site 983545004619 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545004620 active site 983545004621 intersubunit interface [polypeptide binding]; other site 983545004622 catalytic residue [active] 983545004623 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 983545004624 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 983545004625 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 983545004626 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 983545004627 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 983545004628 NADP binding site [chemical binding]; other site 983545004629 dimer interface [polypeptide binding]; other site 983545004630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545004631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545004632 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 983545004633 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 983545004634 putative NAD(P) binding site [chemical binding]; other site 983545004635 dimer interface [polypeptide binding]; other site 983545004636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545004637 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 983545004638 dimer interface [polypeptide binding]; other site 983545004639 active site 983545004640 metal binding site [ion binding]; metal-binding site 983545004641 glutathione binding site [chemical binding]; other site 983545004642 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 983545004643 threonine and homoserine efflux system; Provisional; Region: PRK10532 983545004644 Uncharacterised protein family (UPF0160); Region: UPF0160; cl01749 983545004645 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983545004646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004647 active site 983545004648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004651 dimerization interface [polypeptide binding]; other site 983545004652 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 983545004653 DNA-binding site [nucleotide binding]; DNA binding site 983545004654 RNA-binding motif; other site 983545004655 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 983545004656 Beta-lactamase; Region: Beta-lactamase; cl01009 983545004657 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545004658 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545004659 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 983545004660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004661 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004662 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545004663 putative effector binding pocket; other site 983545004664 dimerization interface [polypeptide binding]; other site 983545004665 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 983545004666 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 983545004667 active site 983545004668 nucleophile elbow; other site 983545004669 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 983545004670 putative substrate binding pocket [chemical binding]; other site 983545004671 trimer interface [polypeptide binding]; other site 983545004672 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545004673 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545004674 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 983545004675 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 983545004676 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545004677 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545004678 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545004679 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545004680 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545004681 catalytic loop [active] 983545004682 iron binding site [ion binding]; other site 983545004683 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545004684 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 983545004685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545004686 ATP binding site [chemical binding]; other site 983545004687 putative Mg++ binding site [ion binding]; other site 983545004688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545004689 nucleotide binding region [chemical binding]; other site 983545004690 ATP-binding site [chemical binding]; other site 983545004691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545004692 transcriptional regulator BetI; Validated; Region: PRK00767 983545004693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545004694 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545004695 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545004696 NAD(P) binding site [chemical binding]; other site 983545004697 catalytic residues [active] 983545004698 choline dehydrogenase; Validated; Region: PRK02106 983545004699 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545004700 BCCT family transporter; Region: BCCT; cl00569 983545004701 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545004702 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545004703 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545004704 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 983545004705 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545004706 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 983545004707 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545004708 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545004709 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545004710 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 983545004711 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545004712 DNA binding residues [nucleotide binding] 983545004713 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545004714 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 983545004715 putative active site [active] 983545004716 putative FMN binding site [chemical binding]; other site 983545004717 putative substrate binding site [chemical binding]; other site 983545004718 putative catalytic residue [active] 983545004719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545004720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004723 dimerization interface [polypeptide binding]; other site 983545004724 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545004725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545004726 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545004727 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545004728 Sulfatase; Region: Sulfatase; cl10460 983545004729 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 983545004730 SmpB-tmRNA interface; other site 983545004731 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 983545004732 putative coenzyme Q binding site [chemical binding]; other site 983545004733 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 983545004734 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 983545004735 Domain of unknown function (DUF299); Region: DUF299; cl00780 983545004736 phosphoenolpyruvate synthase; Validated; Region: PRK06464 983545004737 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 983545004738 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 983545004739 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545004740 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545004741 FAD binding domain; Region: FAD_binding_4; pfam01565 983545004742 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 983545004743 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 983545004744 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 983545004745 Coenzyme A transferase; Region: CoA_trans; cl00773 983545004746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545004747 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 983545004748 Response regulator receiver domain; Region: Response_reg; pfam00072 983545004749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545004750 active site 983545004751 phosphorylation site [posttranslational modification] 983545004752 intermolecular recognition site; other site 983545004753 dimerization interface [polypeptide binding]; other site 983545004754 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 983545004755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545004756 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 983545004757 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545004758 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545004759 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983545004760 short chain dehydrogenase; Provisional; Region: PRK06123 983545004761 classical (c) SDRs; Region: SDR_c; cd05233 983545004762 NAD(P) binding site [chemical binding]; other site 983545004763 active site 983545004764 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004765 GTP-binding protein YchF; Reviewed; Region: PRK09601 983545004766 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 983545004767 G1 box; other site 983545004768 GTP/Mg2+ binding site [chemical binding]; other site 983545004769 Switch I region; other site 983545004770 G2 box; other site 983545004771 Switch II region; other site 983545004772 G3 box; other site 983545004773 G4 box; other site 983545004774 G5 box; other site 983545004775 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 983545004776 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 983545004777 putative active site [active] 983545004778 catalytic residue [active] 983545004779 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 983545004780 5S rRNA interface [nucleotide binding]; other site 983545004781 CTC domain interface; other site 983545004782 L16 interface [polypeptide binding]; other site 983545004783 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545004784 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 983545004785 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 983545004786 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 983545004787 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 983545004788 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 983545004789 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 983545004790 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 983545004791 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 983545004792 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 983545004793 tRNA; other site 983545004794 putative tRNA binding site [nucleotide binding]; other site 983545004795 putative NADP binding site [chemical binding]; other site 983545004796 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 983545004797 peptide chain release factor 1; Validated; Region: prfA; PRK00591 983545004798 RF-1 domain; Region: RF-1; cl02875 983545004799 RF-1 domain; Region: RF-1; cl02875 983545004800 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 983545004801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545004802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545004803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 983545004804 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 983545004805 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545004806 Zn2+ binding site [ion binding]; other site 983545004807 Mg2+ binding site [ion binding]; other site 983545004808 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 983545004809 hypothetical protein; Provisional; Region: PRK10941 983545004810 Uncharacterized conserved protein [Function unknown]; Region: COG2912 983545004811 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 983545004812 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 983545004813 inhibitor-cofactor binding pocket; inhibition site 983545004814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545004815 catalytic residue [active] 983545004816 biotin synthase; Provisional; Region: PRK15108 983545004817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 983545004818 FeS/SAM binding site; other site 983545004819 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 983545004820 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 983545004821 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 983545004822 substrate-cofactor binding pocket; other site 983545004823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545004824 catalytic residue [active] 983545004825 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 983545004826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545004827 S-adenosylmethionine binding site [chemical binding]; other site 983545004828 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545004829 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545004830 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545004831 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545004832 N-terminal plug; other site 983545004833 ligand-binding site [chemical binding]; other site 983545004834 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 983545004835 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 983545004836 putative NAD(P) binding site [chemical binding]; other site 983545004837 dimer interface [polypeptide binding]; other site 983545004838 Major royal jelly protein; Region: MRJP; pfam03022 983545004839 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 983545004840 putative catalytic residues [active] 983545004841 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 983545004842 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 983545004843 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 983545004844 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545004845 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545004846 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 983545004847 Putative ATPase (DUF699); Region: DUF699; pfam05127 983545004848 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545004849 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545004850 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983545004851 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 983545004852 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004853 catalytic residue [active] 983545004854 Fe-S metabolism associated domain; Region: SufE; cl00951 983545004855 Isochorismatase family; Region: Isochorismatase; pfam00857 983545004856 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 983545004857 catalytic triad [active] 983545004858 dimer interface [polypeptide binding]; other site 983545004859 conserved cis-peptide bond; other site 983545004860 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983545004861 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 983545004862 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 983545004863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004864 metal binding site [ion binding]; metal-binding site 983545004865 active site 983545004866 I-site; other site 983545004867 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545004868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545004869 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004870 metal binding site [ion binding]; metal-binding site 983545004871 active site 983545004872 I-site; other site 983545004873 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 983545004874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004875 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 983545004876 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 983545004877 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545004878 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 983545004879 Walker A/P-loop; other site 983545004880 ATP binding site [chemical binding]; other site 983545004881 Q-loop/lid; other site 983545004882 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 983545004883 ABC transporter signature motif; other site 983545004884 Walker B; other site 983545004885 D-loop; other site 983545004886 H-loop/switch region; other site 983545004887 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 983545004888 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 983545004889 FtsZ protein binding site [polypeptide binding]; other site 983545004890 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 983545004891 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 983545004892 nucleotide binding pocket [chemical binding]; other site 983545004893 K-X-D-G motif; other site 983545004894 catalytic site [active] 983545004895 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 983545004896 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 983545004897 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 983545004898 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 983545004899 Dimer interface [polypeptide binding]; other site 983545004900 BRCT sequence motif; other site 983545004901 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 983545004902 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 983545004903 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 983545004904 Competence protein; Region: Competence; cl00471 983545004905 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545004906 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 983545004907 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545004908 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 983545004909 Walker A/P-loop; other site 983545004910 ATP binding site [chemical binding]; other site 983545004911 Q-loop/lid; other site 983545004912 ABC transporter signature motif; other site 983545004913 Walker B; other site 983545004914 D-loop; other site 983545004915 H-loop/switch region; other site 983545004916 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 983545004917 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 983545004918 Trm112p-like protein; Region: Trm112p; cl01066 983545004919 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 983545004920 Ligand binding site [chemical binding]; other site 983545004921 oligomer interface [polypeptide binding]; other site 983545004922 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 983545004923 NADP binding site [chemical binding]; other site 983545004924 homodimer interface [polypeptide binding]; other site 983545004925 active site 983545004926 D-cysteine desulfhydrase; Validated; Region: PRK03910 983545004927 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 983545004928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545004929 catalytic residue [active] 983545004930 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545004931 metal binding site [ion binding]; metal-binding site 983545004932 active site 983545004933 I-site; other site 983545004934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545004935 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 983545004936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545004937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545004939 dimerization interface [polypeptide binding]; other site 983545004940 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 983545004941 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 983545004942 putative ATP binding site [chemical binding]; other site 983545004943 putative substrate interface [chemical binding]; other site 983545004944 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 983545004945 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 983545004946 Substrate binding site [chemical binding]; other site 983545004947 Cupin domain; Region: Cupin_2; cl09118 983545004948 phosphomannomutase CpsG; Provisional; Region: PRK15414 983545004949 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 983545004950 active site 983545004951 substrate binding site [chemical binding]; other site 983545004952 metal binding site [ion binding]; metal-binding site 983545004953 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 983545004954 dimer interface [polypeptide binding]; other site 983545004955 Citrate synthase; Region: Citrate_synt; pfam00285 983545004956 active site 983545004957 citrylCoA binding site [chemical binding]; other site 983545004958 NADH binding [chemical binding]; other site 983545004959 cationic pore residues; other site 983545004960 oxalacetate/citrate binding site [chemical binding]; other site 983545004961 coenzyme A binding site [chemical binding]; other site 983545004962 catalytic triad [active] 983545004963 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 983545004964 Iron-sulfur protein interface; other site 983545004965 proximal quinone binding site [chemical binding]; other site 983545004966 SdhD (CybS) interface [polypeptide binding]; other site 983545004967 proximal heme binding site [chemical binding]; other site 983545004968 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 983545004969 SdhC subunit interface [polypeptide binding]; other site 983545004970 proximal heme binding site [chemical binding]; other site 983545004971 cardiolipin binding site; other site 983545004972 Iron-sulfur protein interface; other site 983545004973 proximal quinone binding site [chemical binding]; other site 983545004974 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 983545004975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545004976 domain; Region: Succ_DH_flav_C; pfam02910 983545004977 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 983545004978 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 983545004979 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 983545004980 TPP-binding site [chemical binding]; other site 983545004981 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 983545004982 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545004983 E3 interaction surface; other site 983545004984 lipoyl attachment site [posttranslational modification]; other site 983545004985 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 983545004986 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545004987 E3 interaction surface; other site 983545004988 lipoyl attachment site [posttranslational modification]; other site 983545004989 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 983545004990 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 983545004991 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545004992 CoA-ligase; Region: Ligase_CoA; pfam00549 983545004993 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 983545004994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545004995 CoA-ligase; Region: Ligase_CoA; pfam00549 983545004996 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545004997 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545004998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545004999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 983545005000 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545005001 substrate binding pocket [chemical binding]; other site 983545005002 membrane-bound complex binding site; other site 983545005003 hinge residues; other site 983545005004 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 983545005005 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 983545005006 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 983545005007 active site pocket [active] 983545005008 oxyanion hole [active] 983545005009 catalytic triad [active] 983545005010 active site nucleophile [active] 983545005011 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005012 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005013 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005014 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545005015 catalytic core [active] 983545005016 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545005017 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545005018 active site 983545005019 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 983545005020 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 983545005021 putative active site [active] 983545005022 putative substrate binding site [chemical binding]; other site 983545005023 ATP binding site [chemical binding]; other site 983545005024 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545005025 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 983545005026 NAD(P) binding site [chemical binding]; other site 983545005027 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545005028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545005029 TPR motif; other site 983545005030 binding surface 983545005031 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 983545005032 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 983545005033 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545005034 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 983545005035 structural tetrad; other site 983545005036 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005037 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545005038 tetramer interface [polypeptide binding]; other site 983545005039 active site 983545005040 Mg2+/Mn2+ binding site [ion binding]; other site 983545005041 Flagellin N-methylase; Region: FliB; cl00497 983545005042 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 983545005043 active site 983545005044 dimer interface [polypeptide binding]; other site 983545005045 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005046 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005047 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005048 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545005049 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545005050 DNA binding site [nucleotide binding] 983545005051 domain linker motif; other site 983545005052 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 983545005053 putative dimerization interface [polypeptide binding]; other site 983545005054 putative ligand binding site [chemical binding]; other site 983545005055 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545005056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005057 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 983545005058 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_1; cd06238 983545005059 putative active site [active] 983545005060 Zn-binding site [ion binding]; other site 983545005061 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005062 Predicted esterase [General function prediction only]; Region: COG0627 983545005063 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 983545005064 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 983545005065 substrate binding site [chemical binding]; other site 983545005066 catalytic Zn binding site [ion binding]; other site 983545005067 NAD binding site [chemical binding]; other site 983545005068 structural Zn binding site [ion binding]; other site 983545005069 dimer interface [polypeptide binding]; other site 983545005070 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545005071 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 983545005072 classical (c) SDRs; Region: SDR_c; cd05233 983545005073 NAD(P) binding site [chemical binding]; other site 983545005074 active site 983545005075 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 983545005076 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 983545005077 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 983545005078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 983545005079 FeS/SAM binding site; other site 983545005080 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 983545005081 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 983545005082 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 983545005083 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545005084 calcium binding site [ion binding]; other site 983545005085 active site 983545005086 catalytic residues [active] 983545005087 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545005088 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005089 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005090 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545005091 Sulfatase; Region: Sulfatase; cl10460 983545005092 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545005093 Sulfatase; Region: Sulfatase; cl10460 983545005094 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 983545005095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545005096 sequence-specific DNA binding site [nucleotide binding]; other site 983545005097 salt bridge; other site 983545005098 Phd_YefM; Region: PhdYeFM; cl09153 983545005099 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 983545005100 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 983545005101 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545005102 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 983545005103 Domain of unknown function (DUF303); Region: DUF303; pfam03629 983545005104 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545005105 Domain of unknown function (DUF303); Region: DUF303; pfam03629 983545005106 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 983545005107 YCII-related domain; Region: YCII; cl00999 983545005108 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 983545005109 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216 983545005110 Trp docking motif; other site 983545005111 'Velcro' closure; other site 983545005112 active site 983545005113 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 983545005114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 983545005115 substrate binding pocket [chemical binding]; other site 983545005116 membrane-bound complex binding site; other site 983545005117 hinge residues; other site 983545005118 Cytochrome c; Region: Cytochrom_C; cl11414 983545005119 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 983545005120 ligand binding site [chemical binding]; other site 983545005121 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 983545005122 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 983545005123 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 983545005124 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 983545005125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545005126 Walker A/P-loop; other site 983545005127 ATP binding site [chemical binding]; other site 983545005128 Q-loop/lid; other site 983545005129 ABC transporter signature motif; other site 983545005130 Walker B; other site 983545005131 D-loop; other site 983545005132 H-loop/switch region; other site 983545005133 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545005134 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005135 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005136 N-terminal plug; other site 983545005137 ligand-binding site [chemical binding]; other site 983545005138 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005139 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005140 N-terminal plug; other site 983545005141 ligand-binding site [chemical binding]; other site 983545005142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545005143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545005144 dimer interface [polypeptide binding]; other site 983545005145 conserved gate region; other site 983545005146 putative PBP binding loops; other site 983545005147 ABC-ATPase subunit interface; other site 983545005148 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 983545005149 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 983545005150 Walker A/P-loop; other site 983545005151 ATP binding site [chemical binding]; other site 983545005152 Q-loop/lid; other site 983545005153 ABC transporter signature motif; other site 983545005154 Walker B; other site 983545005155 D-loop; other site 983545005156 H-loop/switch region; other site 983545005157 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 983545005158 EthD protein; Region: EthD; cl06234 983545005159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545005160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545005161 active site 983545005162 phosphorylation site [posttranslational modification] 983545005163 intermolecular recognition site; other site 983545005164 dimerization interface [polypeptide binding]; other site 983545005165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545005166 DNA binding residues [nucleotide binding] 983545005167 dimerization interface [polypeptide binding]; other site 983545005168 PAS fold; Region: PAS_7; pfam12860 983545005169 PAS fold; Region: PAS_7; pfam12860 983545005170 PAS fold; Region: PAS_4; pfam08448 983545005171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545005172 putative active site [active] 983545005173 heme pocket [chemical binding]; other site 983545005174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545005175 dimer interface [polypeptide binding]; other site 983545005176 phosphorylation site [posttranslational modification] 983545005177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545005178 ATP binding site [chemical binding]; other site 983545005179 Mg2+ binding site [ion binding]; other site 983545005180 G-X-G motif; other site 983545005181 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545005182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545005183 active site 983545005184 phosphorylation site [posttranslational modification] 983545005185 intermolecular recognition site; other site 983545005186 dimerization interface [polypeptide binding]; other site 983545005187 Uncharacterized conserved protein [Function unknown]; Region: COG3287 983545005188 FIST N domain; Region: FIST; pfam08495 983545005189 FIST C domain; Region: FIST_C; pfam10442 983545005190 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 983545005191 FMN-binding domain; Region: FMN_bind; cl01081 983545005192 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 983545005193 NADH dehydrogenase; Region: NADHdh; cl00469 983545005194 4Fe-4S binding domain; Region: Fer4_5; pfam12801 983545005195 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545005196 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545005197 NAD(P) binding site [chemical binding]; other site 983545005198 catalytic residues [active] 983545005199 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 983545005200 NAD(P) binding site [chemical binding]; other site 983545005201 putative active site [active] 983545005202 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 983545005203 30S subunit binding site; other site 983545005204 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 983545005205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545005206 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545005207 substrate binding pocket [chemical binding]; other site 983545005208 dimerization interface [polypeptide binding]; other site 983545005209 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 983545005210 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 983545005211 putative dimer interface [polypeptide binding]; other site 983545005212 putative anticodon binding site; other site 983545005213 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 983545005214 homodimer interface [polypeptide binding]; other site 983545005215 motif 1; other site 983545005216 motif 2; other site 983545005217 active site 983545005218 motif 3; other site 983545005219 cysteine synthases; Region: cysKM; TIGR01136 983545005220 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 983545005221 dimer interface [polypeptide binding]; other site 983545005222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545005223 catalytic residue [active] 983545005224 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545005225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545005226 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 983545005227 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545005228 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 983545005229 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983545005230 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 983545005231 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545005232 active site 983545005233 dimer interface [polypeptide binding]; other site 983545005234 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 983545005235 dimer interface [polypeptide binding]; other site 983545005236 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545005237 active site 983545005238 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983545005239 putative active site [active] 983545005240 putative metal binding site [ion binding]; other site 983545005241 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 983545005242 substrate binding site [chemical binding]; other site 983545005243 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 983545005244 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 983545005245 active site 983545005246 HIGH motif; other site 983545005247 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 983545005248 KMSKS motif; other site 983545005249 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 983545005250 tRNA binding surface [nucleotide binding]; other site 983545005251 anticodon binding site; other site 983545005252 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545005253 active site 983545005254 metal binding site [ion binding]; metal-binding site 983545005255 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545005256 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545005257 catalytic residue [active] 983545005258 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005259 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 983545005260 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005261 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545005262 putative peptidoglycan binding site; other site 983545005263 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 983545005264 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545005265 putative peptidoglycan binding site; other site 983545005266 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545005267 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 983545005268 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 983545005269 active site 983545005270 HIGH motif; other site 983545005271 KMSKS motif; other site 983545005272 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 983545005273 tRNA binding surface [nucleotide binding]; other site 983545005274 anticodon binding site; other site 983545005275 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 983545005276 dimer interface [polypeptide binding]; other site 983545005277 putative tRNA-binding site [nucleotide binding]; other site 983545005278 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 983545005279 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 983545005280 Walker A motif; other site 983545005281 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 983545005282 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 983545005283 trimer interface [polypeptide binding]; other site 983545005284 active site 983545005285 Cupin domain; Region: Cupin_2; cl09118 983545005286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545005287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545005288 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 983545005289 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 983545005290 putative transposase OrfB; Reviewed; Region: PHA02517 983545005291 Integrase core domain; Region: rve; cl01316 983545005292 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 983545005293 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545005294 Beta-lactamase; Region: Beta-lactamase; cl01009 983545005295 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545005296 catalytic residues [active] 983545005297 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 983545005298 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 983545005299 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545005300 NAD binding site [chemical binding]; other site 983545005301 catalytic residues [active] 983545005302 substrate binding site [chemical binding]; other site 983545005303 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 983545005304 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 983545005305 NADP binding site [chemical binding]; other site 983545005306 homodimer interface [polypeptide binding]; other site 983545005307 active site 983545005308 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 983545005309 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 983545005310 NAD(P) binding site [chemical binding]; other site 983545005311 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 983545005312 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 983545005313 active site pocket [active] 983545005314 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545005315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545005316 DNA-binding site [nucleotide binding]; DNA binding site 983545005317 FCD domain; Region: FCD; cl11656 983545005318 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545005319 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005320 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005321 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545005322 SapC; Region: SapC; pfam07277 983545005323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545005324 dimer interface [polypeptide binding]; other site 983545005325 phosphorylation site [posttranslational modification] 983545005326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545005327 ATP binding site [chemical binding]; other site 983545005328 Mg2+ binding site [ion binding]; other site 983545005329 G-X-G motif; other site 983545005330 Response regulator receiver domain; Region: Response_reg; pfam00072 983545005331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545005332 active site 983545005333 phosphorylation site [posttranslational modification] 983545005334 intermolecular recognition site; other site 983545005335 dimerization interface [polypeptide binding]; other site 983545005336 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 983545005337 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 983545005338 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 983545005339 substrate binding pocket [chemical binding]; other site 983545005340 membrane-bound complex binding site; other site 983545005341 hinge residues; other site 983545005342 multidrug efflux protein; Reviewed; Region: PRK01766 983545005343 MatE; Region: MatE; pfam01554 983545005344 MatE; Region: MatE; pfam01554 983545005345 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 983545005346 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 983545005347 dimer interface [polypeptide binding]; other site 983545005348 putative functional site; other site 983545005349 putative MPT binding site; other site 983545005350 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 983545005351 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 983545005352 ATP binding site [chemical binding]; other site 983545005353 substrate interface [chemical binding]; other site 983545005354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 983545005355 TraB family; Region: TraB; cl12050 983545005356 nitrite reductase subunit NirD; Provisional; Region: PRK14989 983545005357 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 983545005358 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 983545005359 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 983545005360 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 983545005361 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 983545005362 [4Fe-4S] binding site [ion binding]; other site 983545005363 molybdopterin cofactor binding site; other site 983545005364 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 983545005365 molybdopterin cofactor binding site; other site 983545005366 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 983545005367 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 983545005368 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 983545005369 hypothetical protein; Validated; Region: PRK09071 983545005370 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 983545005371 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 983545005372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545005373 active site 983545005374 phosphorylation site [posttranslational modification] 983545005375 intermolecular recognition site; other site 983545005376 dimerization interface [polypeptide binding]; other site 983545005377 ANTAR domain; Region: ANTAR; pfam03861 983545005378 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983545005379 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545005380 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 983545005381 catalytic residues [active] 983545005382 dimer interface [polypeptide binding]; other site 983545005383 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545005384 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005385 elongation factor P; Provisional; Region: PRK04542 983545005386 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 983545005387 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 983545005388 RNA binding site [nucleotide binding]; other site 983545005389 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 983545005390 RNA binding site [nucleotide binding]; other site 983545005391 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 983545005392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005393 metal binding site [ion binding]; metal-binding site 983545005394 active site 983545005395 I-site; other site 983545005396 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545005397 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 983545005398 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 983545005399 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 983545005400 NADP binding site [chemical binding]; other site 983545005401 TIGR03440 family protein; Region: unchr_TIGR03440 983545005402 DinB superfamily; Region: DinB_2; cl00986 983545005403 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 983545005404 probable methyltransferase; Region: TIGR03438 983545005405 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 983545005406 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545005407 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545005408 Protein of unknown function (DUF989); Region: DUF989; pfam06181 983545005409 Predicted membrane protein [Function unknown]; Region: COG3748 983545005410 Cytochrome c; Region: Cytochrom_C; cl11414 983545005411 guanine deaminase; Provisional; Region: PRK09228 983545005412 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 983545005413 active site 983545005414 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 983545005415 active site 983545005416 homotetramer interface [polypeptide binding]; other site 983545005417 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 983545005418 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 983545005419 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 983545005420 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 983545005421 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 983545005422 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545005423 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 983545005424 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545005425 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545005426 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 983545005427 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 983545005428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545005429 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 983545005430 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 983545005431 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 983545005432 Sulfate transporter family; Region: Sulfate_transp; cl00967 983545005433 Permease family; Region: Xan_ur_permease; pfam00860 983545005434 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 983545005435 active site 983545005436 purine riboside binding site [chemical binding]; other site 983545005437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005438 putative substrate translocation pore; other site 983545005439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545005440 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 983545005441 Active site [active] 983545005442 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545005443 active site 983545005444 ATP binding site [chemical binding]; other site 983545005445 substrate binding site [chemical binding]; other site 983545005446 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 983545005447 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545005448 substrate binding site [chemical binding]; other site 983545005449 activation loop (A-loop); other site 983545005450 activation loop (A-loop); other site 983545005451 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 983545005452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545005453 dimer interface [polypeptide binding]; other site 983545005454 conserved gate region; other site 983545005455 putative PBP binding loops; other site 983545005456 ABC-ATPase subunit interface; other site 983545005457 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 983545005458 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 983545005459 Walker A/P-loop; other site 983545005460 ATP binding site [chemical binding]; other site 983545005461 Q-loop/lid; other site 983545005462 ABC transporter signature motif; other site 983545005463 Walker B; other site 983545005464 D-loop; other site 983545005465 H-loop/switch region; other site 983545005466 Protein of unknown function (DUF541); Region: SIMPL; cl01077 983545005467 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545005468 Predicted membrane protein [Function unknown]; Region: COG2119 983545005469 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 983545005470 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 983545005471 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545005472 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545005473 FtsX-like permease family; Region: FtsX; pfam02687 983545005474 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 983545005475 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545005476 FtsX-like permease family; Region: FtsX; pfam02687 983545005477 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545005478 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545005479 Walker A/P-loop; other site 983545005480 ATP binding site [chemical binding]; other site 983545005481 Q-loop/lid; other site 983545005482 ABC transporter signature motif; other site 983545005483 Walker B; other site 983545005484 D-loop; other site 983545005485 H-loop/switch region; other site 983545005486 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 983545005487 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545005488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545005489 active site 983545005490 phosphorylation site [posttranslational modification] 983545005491 intermolecular recognition site; other site 983545005492 dimerization interface [polypeptide binding]; other site 983545005493 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 983545005494 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005495 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545005496 N-terminal plug; other site 983545005497 ligand-binding site [chemical binding]; other site 983545005498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 983545005499 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545005500 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 983545005501 active site 983545005502 FMN binding site [chemical binding]; other site 983545005503 2,4-decadienoyl-CoA binding site; other site 983545005504 catalytic residue [active] 983545005505 4Fe-4S cluster binding site [ion binding]; other site 983545005506 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 983545005507 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 983545005508 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 983545005509 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545005510 Outer membrane efflux protein; Region: OEP; pfam02321 983545005511 Outer membrane efflux protein; Region: OEP; pfam02321 983545005512 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 983545005513 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 983545005514 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983545005515 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 983545005516 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 983545005517 putative NAD(P) binding site [chemical binding]; other site 983545005518 putative substrate binding site [chemical binding]; other site 983545005519 catalytic Zn binding site [ion binding]; other site 983545005520 structural Zn binding site [ion binding]; other site 983545005521 dimer interface [polypeptide binding]; other site 983545005522 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 983545005523 active site 983545005524 purine riboside binding site [chemical binding]; other site 983545005525 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 983545005526 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 983545005527 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983545005528 protein binding site [polypeptide binding]; other site 983545005529 Flagellar protein YcgR; Region: YcgR_2; pfam12945 983545005530 PilZ domain; Region: PilZ; cl01260 983545005531 Protein of unknown function (DUF962); Region: DUF962; cl01879 983545005532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 983545005533 Histidine kinase; Region: His_kinase; pfam06580 983545005534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545005535 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 983545005536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545005537 active site 983545005538 phosphorylation site [posttranslational modification] 983545005539 intermolecular recognition site; other site 983545005540 dimerization interface [polypeptide binding]; other site 983545005541 LytTr DNA-binding domain; Region: LytTR; cl04498 983545005542 Uncharacterized conserved protein [Function unknown]; Region: COG2850 983545005543 cyclase homology domain; Region: CHD; cd07302 983545005544 nucleotidyl binding site; other site 983545005545 metal binding site [ion binding]; metal-binding site 983545005546 dimer interface [polypeptide binding]; other site 983545005547 adenylosuccinate lyase; Provisional; Region: PRK09285 983545005548 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 983545005549 tetramer interface [polypeptide binding]; other site 983545005550 active site 983545005551 Protein of unknown function (DUF489); Region: DUF489; cl01097 983545005552 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 983545005553 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 983545005554 PseudoU_synth_RluE: Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-...; Region: PseudoU_synth_RluE; cd02566 983545005555 probable active site [active] 983545005556 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 983545005557 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 983545005558 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 983545005559 DNA-binding site [nucleotide binding]; DNA binding site 983545005560 RNA-binding motif; other site 983545005561 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 983545005562 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 983545005563 Clp amino terminal domain; Region: Clp_N; pfam02861 983545005564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545005565 Walker A motif; other site 983545005566 ATP binding site [chemical binding]; other site 983545005567 Walker B motif; other site 983545005568 arginine finger; other site 983545005569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545005570 Walker A motif; other site 983545005571 ATP binding site [chemical binding]; other site 983545005572 Walker B motif; other site 983545005573 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 983545005574 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 983545005575 rRNA binding site [nucleotide binding]; other site 983545005576 predicted 30S ribosome binding site; other site 983545005577 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 983545005578 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 983545005579 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 983545005580 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 983545005581 thioredoxin reductase; Provisional; Region: PRK10262 983545005582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545005583 Protein of unknown function, DUF412; Region: DUF412; cl01183 983545005584 SprT homologues; Region: SprT; cl01182 983545005585 SprT-like family; Region: SprT-like; pfam10263 983545005586 protease 4; Provisional; Region: PRK10949 983545005587 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 983545005588 tandem repeat interface [polypeptide binding]; other site 983545005589 oligomer interface [polypeptide binding]; other site 983545005590 active site residues [active] 983545005591 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 983545005592 tandem repeat interface [polypeptide binding]; other site 983545005593 oligomer interface [polypeptide binding]; other site 983545005594 active site residues [active] 983545005595 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 983545005596 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 983545005597 RNA/DNA hybrid binding site [nucleotide binding]; other site 983545005598 active site 983545005599 Proteobacterial; Region: dnaQ_proteo; TIGR01406 983545005600 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 983545005601 active site 983545005602 substrate binding site [chemical binding]; other site 983545005603 catalytic site [active] 983545005604 TIGR03503 family protein; Region: TIGR03503 983545005605 Domain of unknown function DUF21; Region: DUF21; pfam01595 983545005606 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545005607 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 983545005608 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545005609 Walker A/P-loop; other site 983545005610 ATP binding site [chemical binding]; other site 983545005611 Q-loop/lid; other site 983545005612 ABC transporter signature motif; other site 983545005613 Walker B; other site 983545005614 D-loop; other site 983545005615 H-loop/switch region; other site 983545005616 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 983545005617 FtsX-like permease family; Region: FtsX; pfam02687 983545005618 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 983545005619 Succinylarginine dihydrolase; Region: AstB; cl01511 983545005620 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 983545005621 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 983545005622 active site 983545005623 interdomain interaction site; other site 983545005624 putative metal-binding site [ion binding]; other site 983545005625 nucleotide binding site [chemical binding]; other site 983545005626 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 983545005627 domain I; other site 983545005628 DNA binding groove [nucleotide binding] 983545005629 phosphate binding site [ion binding]; other site 983545005630 domain II; other site 983545005631 domain III; other site 983545005632 nucleotide binding site [chemical binding]; other site 983545005633 catalytic site [active] 983545005634 domain IV; other site 983545005635 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 983545005636 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 983545005637 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 983545005638 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 983545005639 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 983545005640 HPP family; Region: HPP; pfam04982 983545005641 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 983545005642 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 983545005643 VRR-NUC domain; Region: VRR_NUC; pfam08774 983545005644 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545005645 active site 983545005646 substrate binding site [chemical binding]; other site 983545005647 catalytic site [active] 983545005648 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005649 Cupin domain; Region: Cupin_2; cl09118 983545005650 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545005651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545005652 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 983545005653 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545005654 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 983545005655 NAD(P) binding site [chemical binding]; other site 983545005656 catalytic residues [active] 983545005657 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 983545005658 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 983545005659 Zn binding site [ion binding]; other site 983545005660 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545005661 putative acyl-CoA synthetase; Provisional; Region: PRK06018 983545005662 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 983545005663 classical (c) SDRs; Region: SDR_c; cd05233 983545005664 NAD(P) binding site [chemical binding]; other site 983545005665 active site 983545005666 haloalkane dehalogenase; Provisional; Region: PRK00870 983545005667 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545005668 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545005669 substrate binding site [chemical binding]; other site 983545005670 oxyanion hole (OAH) forming residues; other site 983545005671 trimer interface [polypeptide binding]; other site 983545005672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005673 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545005674 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545005675 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 983545005676 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545005677 dimer interface [polypeptide binding]; other site 983545005678 active site 983545005679 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545005680 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 983545005681 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545005682 active site 983545005683 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545005684 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545005685 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545005686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005687 metal binding site [ion binding]; metal-binding site 983545005688 active site 983545005689 I-site; other site 983545005690 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545005691 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 983545005692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545005693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545005694 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 983545005695 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 983545005696 inhibitor site; inhibition site 983545005697 active site 983545005698 dimer interface [polypeptide binding]; other site 983545005699 catalytic residue [active] 983545005700 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 983545005701 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 983545005702 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005703 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005704 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 983545005705 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 983545005706 active site 983545005707 putative substrate binding pocket [chemical binding]; other site 983545005708 Permease family; Region: Xan_ur_permease; pfam00860 983545005709 Sulfate transporter family; Region: Sulfate_transp; cl00967 983545005710 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545005711 active site 983545005712 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 983545005713 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 983545005714 active site residue [active] 983545005715 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 983545005716 active site residue [active] 983545005717 Protein of unknown function (DUF541); Region: SIMPL; cl01077 983545005718 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 983545005719 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 983545005720 Proline dehydrogenase; Region: Pro_dh; cl03282 983545005721 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 983545005722 Glutamate binding site [chemical binding]; other site 983545005723 NAD binding site [chemical binding]; other site 983545005724 catalytic residues [active] 983545005725 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545005726 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 983545005727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545005728 dihydrodipicolinate reductase; Provisional; Region: PRK00048 983545005729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005730 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 983545005731 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 983545005732 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 983545005733 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 983545005734 catalytic site [active] 983545005735 subunit interface [polypeptide binding]; other site 983545005736 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 983545005737 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545005738 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545005739 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 983545005740 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545005741 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545005742 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 983545005743 IMP binding site; other site 983545005744 dimer interface [polypeptide binding]; other site 983545005745 interdomain contacts; other site 983545005746 partial ornithine binding site; other site 983545005747 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 983545005748 domain; Region: GreA_GreB_N; pfam03449 983545005749 C-term; Region: GreA_GreB; pfam01272 983545005750 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 983545005751 proposed catalytic triad [active] 983545005752 conserved cys residue [active] 983545005753 EamA-like transporter family; Region: EamA; cl01037 983545005754 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545005755 EamA-like transporter family; Region: EamA; cl01037 983545005756 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 983545005757 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 983545005758 putative active site [active] 983545005759 catalytic triad [active] 983545005760 putative dimer interface [polypeptide binding]; other site 983545005761 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 983545005762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545005763 Transporter associated domain; Region: CorC_HlyC; pfam03471 983545005764 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 983545005765 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 983545005766 PhoH-like protein; Region: PhoH; cl12134 983545005767 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 983545005768 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 983545005769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 983545005770 FeS/SAM binding site; other site 983545005771 TRAM domain; Region: TRAM; cl01282 983545005772 NeuB family; Region: NeuB; cl00496 983545005773 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 983545005774 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 983545005775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545005776 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 983545005777 dimerization interface [polypeptide binding]; other site 983545005778 substrate binding pocket [chemical binding]; other site 983545005779 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 983545005780 Protein of unknown function (DUF423); Region: DUF423; cl01008 983545005781 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 983545005782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545005783 SeqA protein; Region: SeqA; cl11470 983545005784 phosphoglucomutase; Validated; Region: PRK07564 983545005785 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 983545005786 active site 983545005787 substrate binding site [chemical binding]; other site 983545005788 metal binding site [ion binding]; metal-binding site 983545005789 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 983545005790 homodimer interface [polypeptide binding]; other site 983545005791 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 983545005792 active site pocket [active] 983545005793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005794 metal binding site [ion binding]; metal-binding site 983545005795 active site 983545005796 I-site; other site 983545005797 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545005798 Peptidase M14 Succinylglutamate desuccinylase (ASTE, also known as N-succinyl-L-glutamate amidohydrolase, N2-succinylglutamate desuccinylase, and SGDS; EC 3.5.1.96) belongs to the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily...; Region: M14_ASTE; cd03855 983545005799 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983545005800 putative active site [active] 983545005801 Zn-binding site [ion binding]; other site 983545005802 Domain of unknown function (DUF74); Region: DUF74; cl00426 983545005803 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 983545005804 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 983545005805 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 983545005806 metal binding site [ion binding]; metal-binding site 983545005807 dimer interface [polypeptide binding]; other site 983545005808 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 983545005809 putative catalytic residues [active] 983545005810 Rhomboid family; Region: Rhomboid; cl11446 983545005811 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 983545005812 active site 983545005813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545005814 metal binding site [ion binding]; metal-binding site 983545005815 active site 983545005816 I-site; other site 983545005817 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 983545005818 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545005819 maltodextrin glucosidase; Provisional; Region: PRK10785 983545005820 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545005821 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545005822 DNA binding site [nucleotide binding] 983545005823 domain linker motif; other site 983545005824 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 983545005825 putative dimerization interface [polypeptide binding]; other site 983545005826 putative ligand binding site [chemical binding]; other site 983545005827 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 983545005828 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545005829 active site 983545005830 HIGH motif; other site 983545005831 nucleotide binding site [chemical binding]; other site 983545005832 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 983545005833 KMSKS motif; other site 983545005834 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 983545005835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005836 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545005837 NAD(P) binding site [chemical binding]; other site 983545005838 active site 983545005839 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 983545005840 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 983545005841 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 983545005842 putative inner membrane peptidase; Provisional; Region: PRK11778 983545005843 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 983545005844 tandem repeat interface [polypeptide binding]; other site 983545005845 oligomer interface [polypeptide binding]; other site 983545005846 active site residues [active] 983545005847 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545005848 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005849 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545005850 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 983545005851 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 983545005852 active site 983545005853 Zn binding site [ion binding]; other site 983545005854 DNA photolyase; Region: DNA_photolyase; pfam00875 983545005855 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 983545005856 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 983545005857 Uncharacterized conserved protein [Function unknown]; Region: COG0327 983545005858 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 983545005859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545005860 S-adenosylmethionine binding site [chemical binding]; other site 983545005861 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 983545005862 catalytic residues [active] 983545005863 dimer interface [polypeptide binding]; other site 983545005864 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 983545005865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545005866 Protein of unknown function (DUF342); Region: DUF342; pfam03961 983545005867 exonuclease I; Provisional; Region: sbcB; PRK11779 983545005868 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 983545005869 active site 983545005870 substrate binding site [chemical binding]; other site 983545005871 catalytic site [active] 983545005872 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 983545005873 FOG: CBS domain [General function prediction only]; Region: COG0517 983545005874 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_16; cd04629 983545005875 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 983545005876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545005877 ATP binding site [chemical binding]; other site 983545005878 putative Mg++ binding site [ion binding]; other site 983545005879 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545005880 nucleotide binding region [chemical binding]; other site 983545005881 ATP-binding site [chemical binding]; other site 983545005882 Helicase associated domain (HA2); Region: HA2; cl04503 983545005883 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 983545005884 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 983545005885 PilZ domain; Region: PilZ; cl01260 983545005886 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 983545005887 PUA domain; Region: PUA; cl00607 983545005888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545005889 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 983545005890 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 983545005891 NAD(P) binding site [chemical binding]; other site 983545005892 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cl09501 983545005893 pseudo EF-hand loop; other site 983545005894 peptide binding pocket; other site 983545005895 Ca2+ binding site [ion binding]; other site 983545005896 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545005897 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545005898 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 983545005899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545005900 active site 983545005901 motif I; other site 983545005902 motif II; other site 983545005903 D-glycerate 3-kinase; Region: PLN02796 983545005904 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545005905 Active site [active] 983545005906 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 983545005907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 983545005908 FeS/SAM binding site; other site 983545005909 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 983545005910 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 983545005911 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 983545005912 GTP binding site [chemical binding]; other site 983545005913 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 983545005914 MPT binding site; other site 983545005915 trimer interface [polypeptide binding]; other site 983545005916 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 983545005917 trimer interface [polypeptide binding]; other site 983545005918 dimer interface [polypeptide binding]; other site 983545005919 putative active site [active] 983545005920 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 983545005921 MoaE interaction surface [polypeptide binding]; other site 983545005922 MoeB interaction surface [polypeptide binding]; other site 983545005923 thiocarboxylated glycine; other site 983545005924 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 983545005925 MoaE homodimer interface [polypeptide binding]; other site 983545005926 MoaD interaction [polypeptide binding]; other site 983545005927 active site residues [active] 983545005928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545005929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545005930 dimer interface [polypeptide binding]; other site 983545005931 conserved gate region; other site 983545005932 putative PBP binding loops; other site 983545005933 ABC-ATPase subunit interface; other site 983545005934 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 983545005935 metal binding site 2 [ion binding]; metal-binding site 983545005936 putative DNA binding helix; other site 983545005937 metal binding site 1 [ion binding]; metal-binding site 983545005938 dimer interface [polypeptide binding]; other site 983545005939 structural Zn2+ binding site [ion binding]; other site 983545005940 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545005941 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 983545005942 acyl-CoA esterase; Provisional; Region: PRK10673 983545005943 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545005944 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 983545005945 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 983545005946 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 983545005947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545005948 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 983545005949 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 983545005950 Ligand binding site [chemical binding]; other site 983545005951 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 983545005952 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 983545005953 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 983545005954 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 983545005955 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 983545005956 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 983545005957 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 983545005958 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545005959 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545005960 conserved cys residue [active] 983545005961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545005962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545005963 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 983545005964 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545005965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545005966 active site 983545005967 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545005968 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545005969 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545005970 NAD(P) binding site [chemical binding]; other site 983545005971 substrate binding site [chemical binding]; other site 983545005972 dimer interface [polypeptide binding]; other site 983545005973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545005974 classical (c) SDRs; Region: SDR_c; cd05233 983545005975 NAD(P) binding site [chemical binding]; other site 983545005976 active site 983545005977 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545005978 classical (c) SDRs; Region: SDR_c; cd05233 983545005979 NAD(P) binding site [chemical binding]; other site 983545005980 active site 983545005981 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 983545005982 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 983545005983 Dicarboxylate transport; Region: DctA-YdbH; cl14674 983545005984 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 983545005985 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 983545005986 ATP binding site [chemical binding]; other site 983545005987 Mg++ binding site [ion binding]; other site 983545005988 motif III; other site 983545005989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545005990 nucleotide binding region [chemical binding]; other site 983545005991 ATP-binding site [chemical binding]; other site 983545005992 ribonuclease E; Reviewed; Region: rne; PRK10811 983545005993 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 983545005994 homodimer interface [polypeptide binding]; other site 983545005995 oligonucleotide binding site [chemical binding]; other site 983545005996 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 983545005997 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 983545005998 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 983545005999 active site 983545006000 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 983545006001 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 983545006002 NAD binding site [chemical binding]; other site 983545006003 substrate binding site [chemical binding]; other site 983545006004 homodimer interface [polypeptide binding]; other site 983545006005 active site 983545006006 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 983545006007 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 983545006008 substrate binding site [chemical binding]; other site 983545006009 tetramer interface [polypeptide binding]; other site 983545006010 Cupin domain; Region: Cupin_2; cl09118 983545006011 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 983545006012 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 983545006013 NADP binding site [chemical binding]; other site 983545006014 active site 983545006015 putative substrate binding site [chemical binding]; other site 983545006016 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 983545006017 active site 983545006018 dimer interface [polypeptide binding]; other site 983545006019 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 983545006020 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 983545006021 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 983545006022 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 983545006023 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 983545006024 dimer interface [polypeptide binding]; other site 983545006025 active site 983545006026 CoA binding pocket [chemical binding]; other site 983545006027 Acyl transferase domain; Region: Acyl_transf_1; cl08282 983545006028 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 983545006029 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545006030 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 983545006031 NAD(P) binding site [chemical binding]; other site 983545006032 homotetramer interface [polypeptide binding]; other site 983545006033 homodimer interface [polypeptide binding]; other site 983545006034 active site 983545006035 Phosphopantetheine attachment site; Region: PP-binding; cl09936 983545006036 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 983545006037 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 983545006038 dimer interface [polypeptide binding]; other site 983545006039 active site 983545006040 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 983545006041 Aminotransferase class IV; Region: Aminotran_4; pfam01063 983545006042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006043 catalytic residue [active] 983545006044 YceG-like family; Region: YceG; pfam02618 983545006045 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 983545006046 dimerization interface [polypeptide binding]; other site 983545006047 thymidylate kinase; Validated; Region: tmk; PRK00698 983545006048 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 983545006049 TMP-binding site; other site 983545006050 ATP-binding site [chemical binding]; other site 983545006051 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 983545006052 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545006053 Walker A motif; other site 983545006054 ATP binding site [chemical binding]; other site 983545006055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545006056 Walker B motif; other site 983545006057 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 983545006058 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545006059 active site 983545006060 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 983545006061 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 983545006062 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545006063 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 983545006064 Protein of unknown function (DUF571); Region: DUF571; pfam04600 983545006065 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 983545006066 Trp docking motif; other site 983545006067 active site 983545006068 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 983545006069 'Velcro' closure; other site 983545006070 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 983545006071 Int/Topo IB signature motif; other site 983545006072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006073 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 983545006074 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 983545006075 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 983545006076 catalytic residues [active] 983545006077 putative transposase OrfB; Reviewed; Region: PHA02517 983545006078 Integrase core domain; Region: rve; cl01316 983545006079 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 983545006080 YeeE/YedE family (DUF395); Region: DUF395; cl01018 983545006081 YeeE/YedE family (DUF395); Region: DUF395; cl01018 983545006082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 983545006083 dimerization interface [polypeptide binding]; other site 983545006084 putative DNA binding site [nucleotide binding]; other site 983545006085 putative Zn2+ binding site [ion binding]; other site 983545006086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006087 putative active site [active] 983545006088 heme pocket [chemical binding]; other site 983545006089 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545006090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545006091 dimer interface [polypeptide binding]; other site 983545006092 phosphorylation site [posttranslational modification] 983545006093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006094 ATP binding site [chemical binding]; other site 983545006095 Mg2+ binding site [ion binding]; other site 983545006096 G-X-G motif; other site 983545006097 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006099 active site 983545006100 phosphorylation site [posttranslational modification] 983545006101 intermolecular recognition site; other site 983545006102 dimerization interface [polypeptide binding]; other site 983545006103 universal stress protein UspE; Provisional; Region: PRK11175 983545006104 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006105 Ligand Binding Site [chemical binding]; other site 983545006106 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006107 Ligand Binding Site [chemical binding]; other site 983545006108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006109 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 983545006110 putative active site [active] 983545006111 heme pocket [chemical binding]; other site 983545006112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 983545006113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006114 ATP binding site [chemical binding]; other site 983545006115 Mg2+ binding site [ion binding]; other site 983545006116 G-X-G motif; other site 983545006117 response regulator FixJ; Provisional; Region: fixJ; PRK09390 983545006118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006119 active site 983545006120 phosphorylation site [posttranslational modification] 983545006121 intermolecular recognition site; other site 983545006122 dimerization interface [polypeptide binding]; other site 983545006123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545006124 DNA binding residues [nucleotide binding] 983545006125 dimerization interface [polypeptide binding]; other site 983545006126 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545006127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006128 active site 983545006129 phosphorylation site [posttranslational modification] 983545006130 intermolecular recognition site; other site 983545006131 dimerization interface [polypeptide binding]; other site 983545006132 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 983545006133 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983545006134 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545006135 metal-binding site [ion binding] 983545006136 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983545006137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 983545006138 Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787 983545006139 DNA binding residues [nucleotide binding] 983545006140 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 983545006141 dimer interface [polypeptide binding]; other site 983545006142 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006144 active site 983545006145 phosphorylation site [posttranslational modification] 983545006146 intermolecular recognition site; other site 983545006147 dimerization interface [polypeptide binding]; other site 983545006148 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006149 metal binding site [ion binding]; metal-binding site 983545006150 active site 983545006151 I-site; other site 983545006152 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 983545006153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006154 6-phosphofructokinase; Provisional; Region: PRK03202 983545006155 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 983545006156 active site 983545006157 ADP/pyrophosphate binding site [chemical binding]; other site 983545006158 dimerization interface [polypeptide binding]; other site 983545006159 allosteric effector site; other site 983545006160 fructose-1,6-bisphosphate binding site; other site 983545006161 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545006162 active site residue [active] 983545006163 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 983545006164 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545006165 ligand binding site [chemical binding]; other site 983545006166 flexible hinge region; other site 983545006167 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 983545006168 putative switch regulator; other site 983545006169 non-specific DNA interactions [nucleotide binding]; other site 983545006170 DNA binding site [nucleotide binding] 983545006171 sequence specific DNA binding site [nucleotide binding]; other site 983545006172 putative cAMP binding site [chemical binding]; other site 983545006173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545006174 dimer interface [polypeptide binding]; other site 983545006175 phosphorylation site [posttranslational modification] 983545006176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006177 ATP binding site [chemical binding]; other site 983545006178 Mg2+ binding site [ion binding]; other site 983545006179 G-X-G motif; other site 983545006180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006181 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006182 active site 983545006183 phosphorylation site [posttranslational modification] 983545006184 intermolecular recognition site; other site 983545006185 dimerization interface [polypeptide binding]; other site 983545006186 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006188 active site 983545006189 phosphorylation site [posttranslational modification] 983545006190 intermolecular recognition site; other site 983545006191 dimerization interface [polypeptide binding]; other site 983545006192 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cd00541 983545006193 dimerization interface [polypeptide binding]; other site 983545006194 substrate binding site [chemical binding]; other site 983545006195 active site 983545006196 calcium binding site [ion binding]; other site 983545006197 OprF membrane domain; Region: OprF; pfam05736 983545006198 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545006199 ligand binding site [chemical binding]; other site 983545006200 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 983545006201 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545006202 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 983545006203 Conserved TM helix; Region: TM_helix; pfam05552 983545006204 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545006205 Domain of unknown function DUF21; Region: DUF21; pfam01595 983545006206 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 983545006207 Ferritin-like domain; Region: Ferritin; pfam00210 983545006208 heme binding site [chemical binding]; other site 983545006209 ferroxidase pore; other site 983545006210 ferroxidase diiron center [ion binding]; other site 983545006211 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 983545006212 Ferritin-like domain; Region: Ferritin; pfam00210 983545006213 heme binding site [chemical binding]; other site 983545006214 ferroxidase pore; other site 983545006215 ferroxidase diiron center [ion binding]; other site 983545006216 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 983545006217 Low-spin heme binding site [chemical binding]; other site 983545006218 Putative water exit pathway; other site 983545006219 Binuclear center (active site) [active] 983545006220 Putative proton exit pathway; other site 983545006221 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 983545006222 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 983545006223 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR...; Region: SQR_QFR_TM; cl00881 983545006224 Iron-sulfur protein interface; other site 983545006225 proximal heme binding site [chemical binding]; other site 983545006226 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 983545006227 Cytochrome c; Region: Cytochrom_C; cl11414 983545006228 Cytochrome c; Region: Cytochrom_C; cl11414 983545006229 FixH; Region: FixH; cl01254 983545006230 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 983545006231 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983545006232 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545006233 metal-binding site [ion binding] 983545006234 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983545006235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 983545006236 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 983545006237 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 983545006238 universal stress protein UspE; Provisional; Region: PRK11175 983545006239 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 983545006240 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006241 Ligand Binding Site [chemical binding]; other site 983545006242 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545006243 FtsX-like permease family; Region: FtsX; pfam02687 983545006244 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 983545006245 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545006246 Walker A/P-loop; other site 983545006247 ATP binding site [chemical binding]; other site 983545006248 Q-loop/lid; other site 983545006249 ABC transporter signature motif; other site 983545006250 Walker B; other site 983545006251 D-loop; other site 983545006252 H-loop/switch region; other site 983545006253 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 983545006254 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 983545006255 Ligand Binding Site [chemical binding]; other site 983545006256 hypothetical protein; Provisional; Region: PRK10279 983545006257 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 983545006258 active site 983545006259 nucleophile elbow; other site 983545006260 EamA-like transporter family; Region: EamA; cl01037 983545006261 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 983545006262 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 983545006263 LysE type translocator; Region: LysE; cl00565 983545006264 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 983545006265 NAD+ binding site [chemical binding]; other site 983545006266 substrate binding site [chemical binding]; other site 983545006267 Zn binding site [ion binding]; other site 983545006268 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 983545006269 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 983545006270 putative active site [active] 983545006271 fumarate hydratase; Reviewed; Region: fumC; PRK00485 983545006272 Class II fumarases; Region: Fumarase_classII; cd01362 983545006273 active site 983545006274 tetramer interface [polypeptide binding]; other site 983545006275 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 983545006276 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 983545006277 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 983545006278 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 983545006279 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545006280 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545006281 catalytic residue [active] 983545006282 allantoate amidohydrolase; Reviewed; Region: PRK09290 983545006283 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 983545006284 active site 983545006285 metal binding site [ion binding]; metal-binding site 983545006286 dimer interface [polypeptide binding]; other site 983545006287 Cupin domain; Region: Cupin_2; cl09118 983545006288 Flavin Reductases; Region: FlaRed; cl00801 983545006289 Glutaminase; Region: Glutaminase; cl00907 983545006290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545006291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545006292 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 983545006293 Walker A/P-loop; other site 983545006294 ATP binding site [chemical binding]; other site 983545006295 Q-loop/lid; other site 983545006296 ABC transporter signature motif; other site 983545006297 Walker B; other site 983545006298 D-loop; other site 983545006299 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545006300 Walker A/P-loop; other site 983545006301 ATP binding site [chemical binding]; other site 983545006302 Q-loop/lid; other site 983545006303 ABC transporter signature motif; other site 983545006304 Walker B; other site 983545006305 D-loop; other site 983545006306 H-loop/switch region; other site 983545006307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545006308 Protein of unknown function (DUF3118); Region: DUF3118; pfam11316 983545006309 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 983545006310 homodimer interface [polypeptide binding]; other site 983545006311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006312 catalytic residue [active] 983545006313 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 983545006314 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 983545006315 trimer interface [polypeptide binding]; other site 983545006316 putative metal binding site [ion binding]; other site 983545006317 acyl-CoA thioesterase II; Provisional; Region: PRK10526 983545006318 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 983545006319 active site 983545006320 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 983545006321 catalytic triad [active] 983545006322 dimer interface [polypeptide binding]; other site 983545006323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 983545006324 active site 983545006325 ATP binding site [chemical binding]; other site 983545006326 substrate binding site [chemical binding]; other site 983545006327 activation loop (A-loop); other site 983545006328 Protein of unknown function (DUF519); Region: DUF519; cl04492 983545006329 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 983545006330 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545006331 E3 interaction surface; other site 983545006332 lipoyl attachment site [posttranslational modification]; other site 983545006333 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545006334 E3 interaction surface; other site 983545006335 lipoyl attachment site [posttranslational modification]; other site 983545006336 e3 binding domain; Region: E3_binding; pfam02817 983545006337 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 983545006338 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 983545006339 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 983545006340 alpha subunit interface [polypeptide binding]; other site 983545006341 TPP binding site [chemical binding]; other site 983545006342 heterodimer interface [polypeptide binding]; other site 983545006343 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983545006344 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 983545006345 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 983545006346 tetramer interface [polypeptide binding]; other site 983545006347 TPP-binding site [chemical binding]; other site 983545006348 heterodimer interface [polypeptide binding]; other site 983545006349 phosphorylation loop region [posttranslational modification] 983545006350 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 983545006351 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 983545006352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545006353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545006354 homodimer interface [polypeptide binding]; other site 983545006355 catalytic residue [active] 983545006356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545006357 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545006358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006359 NAD(P) binding site [chemical binding]; other site 983545006360 active site 983545006361 Vitamin K epoxide reductase family; Region: VKOR; cl01729 983545006362 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 983545006363 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 983545006364 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545006365 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 983545006366 Moco binding site; other site 983545006367 metal coordination site [ion binding]; other site 983545006368 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 983545006369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 983545006370 SEC-C motif; Region: SEC-C; cl12132 983545006371 SEC-C motif; Region: SEC-C; cl12132 983545006372 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 983545006373 active site 1 [active] 983545006374 dimer interface [polypeptide binding]; other site 983545006375 active site 2 [active] 983545006376 Ribosome modulation factor; Region: RMF; cl01207 983545006377 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 983545006378 ABC transporter ATPase component; Reviewed; Region: PRK11147 983545006379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545006380 Walker A/P-loop; other site 983545006381 ATP binding site [chemical binding]; other site 983545006382 Q-loop/lid; other site 983545006383 ABC transporter signature motif; other site 983545006384 Walker B; other site 983545006385 D-loop; other site 983545006386 H-loop/switch region; other site 983545006387 ABC transporter; Region: ABC_tran_2; pfam12848 983545006388 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 983545006389 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545006390 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 983545006391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545006392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545006393 S-adenosylmethionine binding site [chemical binding]; other site 983545006394 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 983545006395 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 983545006396 quinone interaction residues [chemical binding]; other site 983545006397 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 983545006398 active site 983545006399 catalytic residues [active] 983545006400 FMN binding site [chemical binding]; other site 983545006401 substrate binding site [chemical binding]; other site 983545006402 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 983545006403 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545006404 Ycf48-like protein; Provisional; Region: PRK13684 983545006405 Ycf48-like protein; Provisional; Region: PRK13684 983545006406 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545006407 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 983545006408 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 983545006409 aminopeptidase N; Provisional; Region: pepN; PRK14015 983545006410 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 983545006411 active site 983545006412 Zn binding site [ion binding]; other site 983545006413 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 983545006414 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545006415 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545006416 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 983545006417 carboxy-terminal protease; Provisional; Region: PRK11186 983545006418 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 983545006419 protein binding site [polypeptide binding]; other site 983545006420 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 983545006421 Catalytic dyad [active] 983545006422 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 983545006423 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl00174 983545006424 GAF domain; Region: GAF; cl00853 983545006425 Cytochrome C'; Region: Cytochrom_C_2; cl01610 983545006426 chaperone protein DnaJ; Provisional; Region: PRK10767 983545006427 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 983545006428 HSP70 interaction site [polypeptide binding]; other site 983545006429 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 983545006430 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 983545006431 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 983545006432 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 983545006433 dimer interface [polypeptide binding]; other site 983545006434 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 983545006435 Sodium:solute symporter family; Region: SSF; cl00456 983545006436 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545006437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545006438 PAS fold; Region: PAS_7; pfam12860 983545006439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 983545006440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006441 ATP binding site [chemical binding]; other site 983545006442 Mg2+ binding site [ion binding]; other site 983545006443 G-X-G motif; other site 983545006444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006445 active site 983545006446 phosphorylation site [posttranslational modification] 983545006447 intermolecular recognition site; other site 983545006448 Phd_YefM; Region: PhdYeFM; cl09153 983545006449 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 983545006450 RDD family; Region: RDD; cl00746 983545006451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006452 active site 983545006453 phosphorylation site [posttranslational modification] 983545006454 intermolecular recognition site; other site 983545006455 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 983545006456 putative transposase OrfB; Reviewed; Region: PHA02517 983545006457 Integrase core domain; Region: rve; cl01316 983545006458 integron integrase; Region: integrase_gron; TIGR02249 983545006459 DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and a secondary target called the attC (or 59-base element)...; Region: INT_IntI; cd01193 983545006460 Int/Topo IB signature motif; other site 983545006461 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 983545006462 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545006463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006464 active site 983545006465 phosphorylation site [posttranslational modification] 983545006466 intermolecular recognition site; other site 983545006467 dimerization interface [polypeptide binding]; other site 983545006468 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545006469 DNA binding residues [nucleotide binding] 983545006470 dimerization interface [polypeptide binding]; other site 983545006471 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545006472 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006473 N-terminal plug; other site 983545006474 ligand-binding site [chemical binding]; other site 983545006475 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545006476 Citrate transporter; Region: CitMHS; pfam03600 983545006477 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545006478 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 983545006479 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545006480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006481 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 983545006482 NAD(P) binding site [chemical binding]; other site 983545006483 active site 983545006484 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545006485 Phage Tail Collar Domain; Region: Collar; pfam07484 983545006486 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545006487 Phage Tail Collar Domain; Region: Collar; pfam07484 983545006488 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 983545006489 Phage Tail Collar Domain; Region: Collar; pfam07484 983545006490 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 983545006491 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 983545006492 dimer interface [polypeptide binding]; other site 983545006493 active site 983545006494 heme binding site [chemical binding]; other site 983545006495 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 983545006496 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 983545006497 Leucine-rich repeats; other site 983545006498 Substrate binding site [chemical binding]; other site 983545006499 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545006500 active site 983545006501 ATP binding site [chemical binding]; other site 983545006502 substrate binding site [chemical binding]; other site 983545006503 activation loop (A-loop); other site 983545006504 Cytochrome oxidase complex assembly protein 1; Region: Coa1; cl14904 983545006505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545006506 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 983545006507 Protein with unknown function (DUF469); Region: DUF469; cl01237 983545006508 Bacterial pullanase-associated domain; Region: PUD; pfam03714 983545006509 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 983545006510 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 983545006511 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 983545006512 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 983545006513 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545006514 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545006515 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545006516 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545006517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545006518 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545006519 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545006520 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545006521 Cupin superfamily protein; Region: Cupin_4; pfam08007 983545006522 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 983545006523 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 983545006524 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 983545006525 ATP binding site [chemical binding]; other site 983545006526 substrate interface [chemical binding]; other site 983545006527 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545006528 active site residue [active] 983545006529 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 983545006530 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 983545006531 dimer interface [polypeptide binding]; other site 983545006532 substrate binding site [chemical binding]; other site 983545006533 ATP binding site [chemical binding]; other site 983545006534 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 983545006535 thiamine phosphate binding site [chemical binding]; other site 983545006536 active site 983545006537 pyrophosphate binding site [ion binding]; other site 983545006538 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 983545006539 ThiS interaction site; other site 983545006540 putative active site [active] 983545006541 tetramer interface [polypeptide binding]; other site 983545006542 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 983545006543 thiS-thiF/thiG interaction site; other site 983545006544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545006545 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 983545006546 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 983545006547 ThiC family; Region: ThiC; cl08031 983545006548 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 983545006549 RNA/DNA binding site [nucleotide binding]; other site 983545006550 RRM dimerization site [polypeptide binding]; other site 983545006551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545006552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545006553 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545006554 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 983545006555 putative active site [active] 983545006556 putative FMN binding site [chemical binding]; other site 983545006557 putative substrate binding site [chemical binding]; other site 983545006558 putative catalytic residue [active] 983545006559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545006560 putative substrate translocation pore; other site 983545006561 Surface antigen; Region: Surface_Ag_2; cl01155 983545006562 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 983545006563 carboxyltransferase (CT) interaction site; other site 983545006564 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545006565 biotinylation site [posttranslational modification]; other site 983545006566 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545006567 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545006568 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545006569 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 983545006570 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 983545006571 active site 983545006572 catalytic tetrad [active] 983545006573 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545006574 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545006575 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545006576 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 983545006577 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 983545006578 putative [Fe4-S4] binding site [ion binding]; other site 983545006579 putative molybdopterin cofactor binding site [chemical binding]; other site 983545006580 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 983545006581 putative molybdopterin cofactor binding site; other site 983545006582 Protein of unknown function (DUF1272); Region: DUF1272; cl01568 983545006583 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545006584 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545006585 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545006586 Walker A/P-loop; other site 983545006587 ATP binding site [chemical binding]; other site 983545006588 Q-loop/lid; other site 983545006589 ABC transporter signature motif; other site 983545006590 Walker B; other site 983545006591 D-loop; other site 983545006592 H-loop/switch region; other site 983545006593 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 983545006594 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545006595 FtsX-like permease family; Region: FtsX; pfam02687 983545006596 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 983545006597 FtsX-like permease family; Region: FtsX; pfam02687 983545006598 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 983545006599 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 983545006600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545006601 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 983545006602 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545006603 substrate binding site [chemical binding]; other site 983545006604 ATP binding site [chemical binding]; other site 983545006605 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545006606 active site 983545006607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545006608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545006609 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545006610 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545006611 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545006612 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545006613 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545006614 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545006615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545006616 SapC; Region: SapC; pfam07277 983545006617 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 983545006618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545006619 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545006620 Bacterial transcriptional regulator; Region: IclR; pfam01614 983545006621 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545006622 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 983545006623 Protein of unknown function (DUF465); Region: DUF465; cl01070 983545006624 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 983545006625 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545006626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006627 PAS fold; Region: PAS_3; pfam08447 983545006628 putative active site [active] 983545006629 heme pocket [chemical binding]; other site 983545006630 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545006631 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545006632 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 983545006633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006634 active site 983545006635 phosphorylation site [posttranslational modification] 983545006636 intermolecular recognition site; other site 983545006637 dimerization interface [polypeptide binding]; other site 983545006638 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545006639 Zn2+ binding site [ion binding]; other site 983545006640 Mg2+ binding site [ion binding]; other site 983545006641 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 983545006642 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545006643 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545006644 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 983545006645 PAS domain S-box; Region: sensory_box; TIGR00229 983545006646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006647 putative active site [active] 983545006648 heme pocket [chemical binding]; other site 983545006649 PAS domain S-box; Region: sensory_box; TIGR00229 983545006650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006651 putative active site [active] 983545006652 heme pocket [chemical binding]; other site 983545006653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545006654 dimer interface [polypeptide binding]; other site 983545006655 phosphorylation site [posttranslational modification] 983545006656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006657 ATP binding site [chemical binding]; other site 983545006658 Mg2+ binding site [ion binding]; other site 983545006659 G-X-G motif; other site 983545006660 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006662 active site 983545006663 phosphorylation site [posttranslational modification] 983545006664 intermolecular recognition site; other site 983545006665 dimerization interface [polypeptide binding]; other site 983545006666 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545006667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545006668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006669 active site 983545006670 phosphorylation site [posttranslational modification] 983545006671 intermolecular recognition site; other site 983545006672 dimerization interface [polypeptide binding]; other site 983545006673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545006674 DNA binding site [nucleotide binding] 983545006675 sensory histidine kinase CreC; Provisional; Region: PRK11100 983545006676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545006677 dimer interface [polypeptide binding]; other site 983545006678 phosphorylation site [posttranslational modification] 983545006679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545006680 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545006681 GAF domain; Region: GAF; cl00853 983545006682 GAF domain; Region: GAF; cl00853 983545006683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006684 metal binding site [ion binding]; metal-binding site 983545006685 active site 983545006686 I-site; other site 983545006687 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545006688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545006689 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 983545006690 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 983545006691 active site 983545006692 catalytic tetrad [active] 983545006693 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545006694 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545006695 hypothetical protein; Provisional; Region: PRK11281 983545006696 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 983545006697 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545006698 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545006699 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006700 N-terminal plug; other site 983545006701 ligand-binding site [chemical binding]; other site 983545006702 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 983545006703 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 983545006704 FAD binding pocket [chemical binding]; other site 983545006705 FAD binding motif [chemical binding]; other site 983545006706 phosphate binding motif [ion binding]; other site 983545006707 NAD binding pocket [chemical binding]; other site 983545006708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545006709 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545006710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006711 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 983545006712 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 983545006713 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545006714 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 983545006715 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 983545006716 Active site [active] 983545006717 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545006718 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545006719 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 983545006720 N-terminal domain interface [polypeptide binding]; other site 983545006721 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545006722 gluconate transporter; Region: gntP; TIGR00791 983545006723 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 983545006724 homotrimer interaction site [polypeptide binding]; other site 983545006725 putative active site [active] 983545006726 DNA helicase IV; Provisional; Region: helD; PRK11054 983545006727 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545006728 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545006729 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 983545006730 Protein of unknown function (DUF421); Region: DUF421; cl00990 983545006731 UPF0126 domain; Region: UPF0126; pfam03458 983545006732 Predicted membrane protein [Function unknown]; Region: COG2860 983545006733 UPF0126 domain; Region: UPF0126; pfam03458 983545006734 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545006735 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545006736 PAS domain S-box; Region: sensory_box; TIGR00229 983545006737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545006738 PAS fold; Region: PAS_3; pfam08447 983545006739 putative active site [active] 983545006740 heme pocket [chemical binding]; other site 983545006741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 983545006742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545006743 dimer interface [polypeptide binding]; other site 983545006744 phosphorylation site [posttranslational modification] 983545006745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006746 ATP binding site [chemical binding]; other site 983545006747 Mg2+ binding site [ion binding]; other site 983545006748 G-X-G motif; other site 983545006749 Response regulator receiver domain; Region: Response_reg; pfam00072 983545006750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006751 active site 983545006752 phosphorylation site [posttranslational modification] 983545006753 intermolecular recognition site; other site 983545006754 dimerization interface [polypeptide binding]; other site 983545006755 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 983545006756 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 983545006757 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 983545006758 active site 983545006759 substrate binding site [chemical binding]; other site 983545006760 FMN binding site [chemical binding]; other site 983545006761 putative catalytic residues [active] 983545006762 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 983545006763 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006764 N-terminal plug; other site 983545006765 ligand-binding site [chemical binding]; other site 983545006766 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545006767 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545006768 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545006769 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545006770 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545006771 FAD binding domain; Region: FAD_binding_4; pfam01565 983545006772 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 983545006773 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 983545006774 active site 983545006775 substrate-binding site [chemical binding]; other site 983545006776 metal-binding site [ion binding] 983545006777 ATP binding site [chemical binding]; other site 983545006778 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 983545006779 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545006780 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545006781 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545006782 Cupin domain; Region: Cupin_2; cl09118 983545006783 Cupin domain; Region: Cupin_2; cl09118 983545006784 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545006785 classical (c) SDRs; Region: SDR_c; cd05233 983545006786 NAD(P) binding site [chemical binding]; other site 983545006787 active site 983545006788 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 983545006789 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 983545006790 NAD binding site [chemical binding]; other site 983545006791 dimerization interface [polypeptide binding]; other site 983545006792 product binding site; other site 983545006793 substrate binding site [chemical binding]; other site 983545006794 zinc binding site [ion binding]; other site 983545006795 catalytic residues [active] 983545006796 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545006797 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545006798 DNA binding site [nucleotide binding] 983545006799 domain linker motif; other site 983545006800 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 983545006801 putative dimerization interface [polypeptide binding]; other site 983545006802 putative ligand binding site [chemical binding]; other site 983545006803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545006804 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545006805 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 983545006806 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545006807 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 983545006808 Ligand Binding Site [chemical binding]; other site 983545006809 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545006810 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545006811 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545006812 Sodium:solute symporter family; Region: SSF; cl00456 983545006813 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545006814 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006815 N-terminal plug; other site 983545006816 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545006817 ligand-binding site [chemical binding]; other site 983545006818 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545006819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545006820 Coenzyme A binding pocket [chemical binding]; other site 983545006821 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 983545006822 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 983545006823 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 983545006824 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 983545006825 FAD binding pocket [chemical binding]; other site 983545006826 FAD binding motif [chemical binding]; other site 983545006827 phosphate binding motif [ion binding]; other site 983545006828 beta-alpha-beta structure motif; other site 983545006829 NAD binding pocket [chemical binding]; other site 983545006830 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 983545006831 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 983545006832 LysE type translocator; Region: LysE; cl00565 983545006833 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 983545006834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545006835 cofactor binding site; other site 983545006836 DNA binding site [nucleotide binding] 983545006837 substrate interaction site [chemical binding]; other site 983545006838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545006839 Protein of unknown function DUF262; Region: DUF262; cl14890 983545006840 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 983545006841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545006842 Uncharacterized conserved protein [Function unknown]; Region: COG4938 983545006843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 983545006844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006845 active site 983545006846 phosphorylation site [posttranslational modification] 983545006847 intermolecular recognition site; other site 983545006848 dimerization interface [polypeptide binding]; other site 983545006849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545006850 DNA binding residues [nucleotide binding] 983545006851 dimerization interface [polypeptide binding]; other site 983545006852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 983545006853 Cache domain; Region: Cache_2; pfam08269 983545006854 Histidine kinase; Region: HisKA_3; pfam07730 983545006855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006856 ATP binding site [chemical binding]; other site 983545006857 Mg2+ binding site [ion binding]; other site 983545006858 G-X-G motif; other site 983545006859 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 983545006860 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 983545006861 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545006862 DctM-like transporters; Region: DctM; pfam06808 983545006863 Cytochrome b562; Region: Cytochrom_B562; cl01546 983545006864 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 983545006865 E-class dimer interface [polypeptide binding]; other site 983545006866 P-class dimer interface [polypeptide binding]; other site 983545006867 active site 983545006868 Cu2+ binding site [ion binding]; other site 983545006869 Zn2+ binding site [ion binding]; other site 983545006870 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 983545006871 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 983545006872 dimer interface [polypeptide binding]; other site 983545006873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545006874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545006875 active site 983545006876 phosphorylation site [posttranslational modification] 983545006877 intermolecular recognition site; other site 983545006878 dimerization interface [polypeptide binding]; other site 983545006879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545006880 DNA binding site [nucleotide binding] 983545006881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545006882 dimer interface [polypeptide binding]; other site 983545006883 phosphorylation site [posttranslational modification] 983545006884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545006885 ATP binding site [chemical binding]; other site 983545006886 Mg2+ binding site [ion binding]; other site 983545006887 G-X-G motif; other site 983545006888 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 983545006889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545006890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545006891 Cytochrome P450; Region: p450; cl12078 983545006892 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545006893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545006894 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 983545006895 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 983545006896 NAD binding site [chemical binding]; other site 983545006897 catalytic Zn binding site [ion binding]; other site 983545006898 substrate binding site [chemical binding]; other site 983545006899 structural Zn binding site [ion binding]; other site 983545006900 Putative esterase; Region: Esterase; pfam00756 983545006901 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 983545006902 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545006903 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 983545006904 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545006905 Catalytic site [active] 983545006906 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 983545006907 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 983545006908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545006909 binding surface 983545006910 TPR motif; other site 983545006911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545006912 metal binding site [ion binding]; metal-binding site 983545006913 active site 983545006914 I-site; other site 983545006915 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 983545006916 NADP binding site [chemical binding]; other site 983545006917 dimer interface [polypeptide binding]; other site 983545006918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545006919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545006920 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545006921 putative effector binding pocket; other site 983545006922 dimerization interface [polypeptide binding]; other site 983545006923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545006924 DNA binding site [nucleotide binding] 983545006925 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 983545006926 putative active site [active] 983545006927 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545006928 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006929 N-terminal plug; other site 983545006930 ligand-binding site [chemical binding]; other site 983545006931 Putative cyclase; Region: Cyclase; cl00814 983545006932 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 983545006933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006934 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545006935 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 983545006936 Cupin domain; Region: Cupin_2; cl09118 983545006937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545006938 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 983545006939 NAD(P) binding site [chemical binding]; other site 983545006940 active site 983545006941 Sodium:solute symporter family; Region: SSF; cl00456 983545006942 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545006943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545006944 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545006945 Bacterial transcriptional regulator; Region: IclR; pfam01614 983545006946 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 983545006947 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 983545006948 active site 983545006949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545006950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545006951 putative substrate translocation pore; other site 983545006952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545006953 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 983545006954 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545006955 ATP binding site [chemical binding]; other site 983545006956 Mg++ binding site [ion binding]; other site 983545006957 motif III; other site 983545006958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545006959 nucleotide binding region [chemical binding]; other site 983545006960 ATP-binding site [chemical binding]; other site 983545006961 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545006962 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545006963 N-terminal plug; other site 983545006964 ligand-binding site [chemical binding]; other site 983545006965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545006966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545006967 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545006968 dimerization interface [polypeptide binding]; other site 983545006969 substrate binding pocket [chemical binding]; other site 983545006970 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 983545006971 intersubunit interface [polypeptide binding]; other site 983545006972 active site 983545006973 Zn2+ binding site [ion binding]; other site 983545006974 A functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site...; Region: Peptidase_M14-like_4; cd06231 983545006975 putative active site [active] 983545006976 Zn-binding site [ion binding]; other site 983545006977 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 983545006978 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 983545006979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545006980 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 983545006981 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 983545006982 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545006983 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 983545006984 CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY. CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598 983545006985 putative active site [active] 983545006986 putative catalytic site [active] 983545006987 Putative esterase; Region: Esterase; pfam00756 983545006988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545006989 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545006990 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545006991 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 983545006992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 983545006993 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 983545006994 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 983545006995 DNA binding residues [nucleotide binding] 983545006996 putative dimer interface [polypeptide binding]; other site 983545006997 putative metal binding residues [ion binding]; other site 983545006998 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 983545006999 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 983545007000 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 983545007001 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 983545007002 UvrB/uvrC motif; Region: UVR; pfam02151 983545007003 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 983545007004 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 983545007005 response regulator; Provisional; Region: PRK09483 983545007006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007007 active site 983545007008 phosphorylation site [posttranslational modification] 983545007009 intermolecular recognition site; other site 983545007010 dimerization interface [polypeptide binding]; other site 983545007011 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545007012 DNA binding residues [nucleotide binding] 983545007013 dimerization interface [polypeptide binding]; other site 983545007014 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 983545007015 DsrE/DsrF-like family; Region: DrsE; cl00672 983545007016 DsrE/DsrF-like family; Region: DrsE; cl00672 983545007017 DsrH like protein; Region: DsrH; cl00953 983545007018 DsrC like protein; Region: DsrC; cl01101 983545007019 seryl-tRNA synthetase; Provisional; Region: PRK05431 983545007020 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 983545007021 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 983545007022 dimer interface [polypeptide binding]; other site 983545007023 active site 983545007024 motif 1; other site 983545007025 motif 2; other site 983545007026 motif 3; other site 983545007027 CrcB-like protein; Region: CRCB; cl09114 983545007028 recombination factor protein RarA; Reviewed; Region: PRK13342 983545007029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545007030 Walker A motif; other site 983545007031 ATP binding site [chemical binding]; other site 983545007032 Walker B motif; other site 983545007033 arginine finger; other site 983545007034 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 983545007035 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 983545007036 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 983545007037 DNA translocase FtsK; Provisional; Region: PRK10263 983545007038 DNA translocase FtsK; Provisional; Region: PRK10263 983545007039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545007040 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 983545007041 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 983545007042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545007043 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 983545007044 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 983545007045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007046 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 983545007047 active site 983545007048 dimer interface [polypeptide binding]; other site 983545007049 tetratricopeptide repeat protein; Provisional; Region: PRK11788 983545007050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545007051 binding surface 983545007052 TPR motif; other site 983545007053 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 983545007054 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 983545007055 IHF dimer interface [polypeptide binding]; other site 983545007056 IHF - DNA interface [nucleotide binding]; other site 983545007057 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 983545007058 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 983545007059 RNA binding site [nucleotide binding]; other site 983545007060 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 983545007061 RNA binding site [nucleotide binding]; other site 983545007062 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 983545007063 RNA binding site [nucleotide binding]; other site 983545007064 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 983545007065 RNA binding site [nucleotide binding]; other site 983545007066 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 983545007067 RNA binding site [nucleotide binding]; other site 983545007068 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 983545007069 RNA binding site [nucleotide binding]; other site 983545007070 cytidylate kinase; Provisional; Region: cmk; PRK00023 983545007071 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 983545007072 CMP-binding site; other site 983545007073 The sites determining sugar specificity; other site 983545007074 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 983545007075 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 983545007076 hinge; other site 983545007077 active site 983545007078 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 983545007079 homodimer interface [polypeptide binding]; other site 983545007080 substrate-cofactor binding pocket; other site 983545007081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545007082 catalytic residue [active] 983545007083 DNA gyrase subunit A; Validated; Region: PRK05560 983545007084 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 983545007085 CAP-like domain; other site 983545007086 Active site [active] 983545007087 primary dimer interface [polypeptide binding]; other site 983545007088 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007089 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007090 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007091 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007092 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007093 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 983545007094 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 983545007095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545007096 S-adenosylmethionine binding site [chemical binding]; other site 983545007097 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 983545007098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545007099 motif II; other site 983545007100 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 983545007101 ATP cone domain; Region: ATP-cone; pfam03477 983545007102 Class I ribonucleotide reductase; Region: RNR_I; cd01679 983545007103 active site 983545007104 dimer interface [polypeptide binding]; other site 983545007105 catalytic residues [active] 983545007106 effector binding site; other site 983545007107 R2 peptide binding site; other site 983545007108 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 983545007109 dimer interface [polypeptide binding]; other site 983545007110 putative radical transfer pathway; other site 983545007111 diiron center [ion binding]; other site 983545007112 tyrosyl radical; other site 983545007113 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 983545007114 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545007115 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545007116 active site 983545007117 dimer interface [polypeptide binding]; other site 983545007118 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 983545007119 Ligand Binding Site [chemical binding]; other site 983545007120 Molecular Tunnel; other site 983545007121 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 983545007122 ATP binding site [chemical binding]; other site 983545007123 active site 983545007124 substrate binding site [chemical binding]; other site 983545007125 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 983545007126 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 983545007127 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 983545007128 dihydrodipicolinate synthase; Region: dapA; TIGR00674 983545007129 dimer interface [polypeptide binding]; other site 983545007130 active site 983545007131 catalytic residue [active] 983545007132 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 983545007133 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545007134 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 983545007135 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 983545007136 catalytic triad [active] 983545007137 Domain of unknown function DUF20; Region: UPF0118; cl00465 983545007138 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 983545007139 Peptidase family M48; Region: Peptidase_M48; cl12018 983545007140 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 983545007141 catalytic residues [active] 983545007142 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 983545007143 catalytic residues [active] 983545007144 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545007145 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 983545007146 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545007147 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; cl01278 983545007148 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 983545007149 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 983545007150 dimerization interface [polypeptide binding]; other site 983545007151 putative ATP binding site [chemical binding]; other site 983545007152 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 983545007153 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 983545007154 active site 983545007155 substrate binding site [chemical binding]; other site 983545007156 cosubstrate binding site; other site 983545007157 catalytic site [active] 983545007158 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 983545007159 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 983545007160 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 983545007161 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545007162 active site 983545007163 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 983545007164 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 983545007165 IHF dimer interface [polypeptide binding]; other site 983545007166 IHF - DNA interface [nucleotide binding]; other site 983545007167 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 983545007168 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 983545007169 putative tRNA-binding site [nucleotide binding]; other site 983545007170 B3/4 domain; Region: B3_4; cl11458 983545007171 tRNA synthetase B5 domain; Region: B5; cl08394 983545007172 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 983545007173 dimer interface [polypeptide binding]; other site 983545007174 motif 1; other site 983545007175 motif 3; other site 983545007176 motif 2; other site 983545007177 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 983545007178 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 983545007179 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 983545007180 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 983545007181 dimer interface [polypeptide binding]; other site 983545007182 motif 1; other site 983545007183 active site 983545007184 motif 2; other site 983545007185 motif 3; other site 983545007186 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 983545007187 23S rRNA binding site [nucleotide binding]; other site 983545007188 L21 binding site [polypeptide binding]; other site 983545007189 L13 binding site [polypeptide binding]; other site 983545007190 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 983545007191 translation initiation factor IF-3; Region: infC; TIGR00168 983545007192 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 983545007193 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 983545007194 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 983545007195 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 983545007196 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 983545007197 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 983545007198 active site 983545007199 dimer interface [polypeptide binding]; other site 983545007200 motif 1; other site 983545007201 motif 2; other site 983545007202 motif 3; other site 983545007203 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 983545007204 anticodon binding site; other site 983545007205 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545007206 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 983545007207 NADP binding site [chemical binding]; other site 983545007208 substrate binding pocket [chemical binding]; other site 983545007209 active site 983545007210 Protein of unknown function (DUF3080); Region: DUF3080; pfam11279 983545007211 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 983545007212 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 983545007213 active site 983545007214 substrate binding site [chemical binding]; other site 983545007215 catalytic site [active] 983545007216 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 983545007217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 983545007218 ligand binding site [chemical binding]; other site 983545007219 flexible hinge region; other site 983545007220 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 983545007221 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545007222 metal binding triad; other site 983545007223 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 983545007224 BCCT family transporter; Region: BCCT; cl00569 983545007225 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 983545007226 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 983545007227 DNA binding site [nucleotide binding] 983545007228 Int/Topo IB signature motif; other site 983545007229 active site 983545007230 catalytic residues [active] 983545007231 potential frameshift: common BLAST hit: gi|209397642|ref|YP_002271427.1| phage portal protein, lambda family 983545007232 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 983545007233 oligomer interface [polypeptide binding]; other site 983545007234 active site residues [active] 983545007235 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 983545007236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007237 active site 983545007238 phosphorylation site [posttranslational modification] 983545007239 intermolecular recognition site; other site 983545007240 dimerization interface [polypeptide binding]; other site 983545007241 CheB methylesterase; Region: CheB_methylest; pfam01339 983545007242 CheD chemotactic sensory transduction; Region: CheD; cl00810 983545007243 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 983545007244 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 983545007245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545007246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007247 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545007248 putative active site [active] 983545007249 heme pocket [chemical binding]; other site 983545007250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007251 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545007252 putative active site [active] 983545007253 heme pocket [chemical binding]; other site 983545007254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007255 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 983545007256 putative active site [active] 983545007257 heme pocket [chemical binding]; other site 983545007258 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007259 putative active site [active] 983545007260 heme pocket [chemical binding]; other site 983545007261 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 983545007262 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545007263 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 983545007264 putative CheA interaction surface; other site 983545007265 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 983545007266 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 983545007267 putative binding surface; other site 983545007268 active site 983545007269 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 983545007270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545007271 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 983545007272 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007274 active site 983545007275 phosphorylation site [posttranslational modification] 983545007276 intermolecular recognition site; other site 983545007277 dimerization interface [polypeptide binding]; other site 983545007278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007279 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007280 active site 983545007281 phosphorylation site [posttranslational modification] 983545007282 intermolecular recognition site; other site 983545007283 dimerization interface [polypeptide binding]; other site 983545007284 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 983545007285 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545007286 anti sigma factor interaction site; other site 983545007287 regulatory phosphorylation site [posttranslational modification]; other site 983545007288 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 983545007289 Uncharacterized conserved protein [Function unknown]; Region: COG3603 983545007290 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 983545007291 HPr interaction site; other site 983545007292 glycerol kinase (GK) interaction site [polypeptide binding]; other site 983545007293 active site 983545007294 phosphorylation site [posttranslational modification] 983545007295 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545007296 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 983545007297 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545007298 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545007299 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545007300 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 983545007301 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545007302 catalytic loop [active] 983545007303 iron binding site [ion binding]; other site 983545007304 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545007305 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 983545007306 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 983545007307 Ligand binding site [chemical binding]; other site 983545007308 metal binding site [ion binding]; metal-binding site 983545007309 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 983545007310 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 983545007311 RDD family; Region: RDD; cl00746 983545007312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545007313 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 983545007314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545007315 Walker A motif; other site 983545007316 ATP binding site [chemical binding]; other site 983545007317 Walker B motif; other site 983545007318 arginine finger; other site 983545007319 cysteine synthases; Region: cysKM; TIGR01136 983545007320 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 983545007321 dimer interface [polypeptide binding]; other site 983545007322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545007323 catalytic residue [active] 983545007324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 983545007325 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 983545007326 Rhomboid family; Region: Rhomboid; cl11446 983545007327 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 983545007328 CsbD-like; Region: CsbD; cl01272 983545007329 Protein of unknown function (DUF419); Region: DUF419; cl09948 983545007330 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 983545007331 LolC/E family; Region: lolCE; TIGR02212 983545007332 PilZ domain; Region: PilZ; cl01260 983545007333 transcription-repair coupling factor; Provisional; Region: PRK10689 983545007334 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 983545007335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545007336 ATP binding site [chemical binding]; other site 983545007337 putative Mg++ binding site [ion binding]; other site 983545007338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545007339 nucleotide binding region [chemical binding]; other site 983545007340 ATP-binding site [chemical binding]; other site 983545007341 TRCF domain; Region: TRCF; pfam03461 983545007342 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545007343 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545007344 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 983545007345 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545007346 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545007347 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545007348 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 983545007349 homotrimer interaction site [polypeptide binding]; other site 983545007350 putative active site [active] 983545007351 Cytochrome c; Region: Cytochrom_C; cl11414 983545007352 Cytochrome c; Region: Cytochrom_C; cl11414 983545007353 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 983545007354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545007356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545007357 dimerization interface [polypeptide binding]; other site 983545007358 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 983545007359 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 983545007360 transmembrane helices; other site 983545007361 Citrate transporter; Region: CitMHS; pfam03600 983545007362 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545007363 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 983545007364 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 983545007365 recombination and repair protein; Provisional; Region: PRK10869 983545007366 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 983545007367 Walker A/P-loop; other site 983545007368 ATP binding site [chemical binding]; other site 983545007369 Q-loop/lid; other site 983545007370 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 983545007371 ABC transporter signature motif; other site 983545007372 Walker B; other site 983545007373 D-loop; other site 983545007374 H-loop/switch region; other site 983545007375 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 983545007376 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 983545007377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545007378 Walker A/P-loop; other site 983545007379 ATP binding site [chemical binding]; other site 983545007380 Q-loop/lid; other site 983545007381 ABC transporter signature motif; other site 983545007382 Walker B; other site 983545007383 D-loop; other site 983545007384 H-loop/switch region; other site 983545007385 ABC transporter; Region: ABC_tran_2; pfam12848 983545007386 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 983545007387 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 983545007388 putative metal binding site [ion binding]; other site 983545007389 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 983545007390 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 983545007391 G1 box; other site 983545007392 GTP/Mg2+ binding site [chemical binding]; other site 983545007393 Switch I region; other site 983545007394 G2 box; other site 983545007395 G3 box; other site 983545007396 Switch II region; other site 983545007397 G4 box; other site 983545007398 G5 box; other site 983545007399 Nucleoside recognition; Region: Gate; cl00486 983545007400 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 983545007401 Nucleoside recognition; Region: Gate; cl00486 983545007402 FeoA domain; Region: FeoA; cl00838 983545007403 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 983545007404 Low molecular weight phosphatase family; Region: LMWPc; cd00115 983545007405 Active site [active] 983545007406 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 983545007407 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545007408 Paraquat-inducible protein A; Region: PqiA; pfam04403 983545007409 paraquat-inducible protein B; Provisional; Region: PRK10807 983545007410 mce related protein; Region: MCE; cl03606 983545007411 mce related protein; Region: MCE; cl03606 983545007412 Protein of unknown function (DUF330); Region: DUF330; cl01135 983545007413 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 983545007414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007415 metal binding site [ion binding]; metal-binding site 983545007416 active site 983545007417 I-site; other site 983545007418 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545007419 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 983545007420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545007421 Walker A/P-loop; other site 983545007422 ATP binding site [chemical binding]; other site 983545007423 Q-loop/lid; other site 983545007424 ABC transporter signature motif; other site 983545007425 Walker B; other site 983545007426 D-loop; other site 983545007427 H-loop/switch region; other site 983545007428 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 983545007429 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 983545007430 16S/18S rRNA binding site [nucleotide binding]; other site 983545007431 S13e-L30e interaction site [polypeptide binding]; other site 983545007432 25S rRNA binding site [nucleotide binding]; other site 983545007433 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 983545007434 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 983545007435 RNA binding site [nucleotide binding]; other site 983545007436 active site 983545007437 Ribosome-binding factor A; Region: RBFA; cl00542 983545007438 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 983545007439 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 983545007440 translation initiation factor IF-2; Region: IF-2; TIGR00487 983545007441 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 983545007442 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 983545007443 G1 box; other site 983545007444 putative GEF interaction site [polypeptide binding]; other site 983545007445 GTP/Mg2+ binding site [chemical binding]; other site 983545007446 Switch I region; other site 983545007447 G2 box; other site 983545007448 G3 box; other site 983545007449 Switch II region; other site 983545007450 G4 box; other site 983545007451 G5 box; other site 983545007452 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 983545007453 Translation-initiation factor 2; Region: IF-2; pfam11987 983545007454 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 983545007455 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 983545007456 NusA N-terminal domain; Region: NusA_N; pfam08529 983545007457 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 983545007458 RNA binding site [nucleotide binding]; other site 983545007459 homodimer interface [polypeptide binding]; other site 983545007460 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 983545007461 G-X-X-G motif; other site 983545007462 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 983545007463 ribosome maturation protein RimP; Reviewed; Region: PRK00092 983545007464 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 983545007465 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 983545007466 Sm1 motif; other site 983545007467 D3 - B interaction site; other site 983545007468 D1 - D2 interaction site; other site 983545007469 Hfq - Hfq interaction site; other site 983545007470 RNA binding pocket [nucleotide binding]; other site 983545007471 Sm2 motif; other site 983545007472 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 983545007473 aromatic arch; other site 983545007474 DCoH dimer interaction site [polypeptide binding]; other site 983545007475 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 983545007476 DCoH tetramer interaction site [polypeptide binding]; other site 983545007477 substrate binding site [chemical binding]; other site 983545007478 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545007479 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545007480 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545007481 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545007482 active site 2 [active] 983545007483 active site 1 [active] 983545007484 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 983545007485 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545007486 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 983545007487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545007488 active site 983545007489 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 983545007490 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545007491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545007492 catalytic residue [active] 983545007493 galactonate dehydratase; Provisional; Region: PRK14017 983545007494 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 983545007495 active site pocket [active] 983545007496 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 983545007497 intersubunit interface [polypeptide binding]; other site 983545007498 active site 983545007499 Zn2+ binding site [ion binding]; other site 983545007500 PPIC-type PPIASE domain; Region: Rotamase; cl08278 983545007501 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 983545007502 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545007503 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007504 metal binding site [ion binding]; metal-binding site 983545007505 active site 983545007506 I-site; other site 983545007507 Predicted acyltransferase [General function prediction only]; Region: COG4801 983545007508 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 983545007509 putative metal binding site [ion binding]; other site 983545007510 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 983545007511 Interdomain contacts; other site 983545007512 Cytokine receptor motif; other site 983545007513 DoxX; Region: DoxX; cl00976 983545007514 Cupin domain; Region: Cupin_2; cl09118 983545007515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545007516 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 983545007517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545007518 dimerization interface [polypeptide binding]; other site 983545007519 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545007520 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545007521 NAD(P) binding site [chemical binding]; other site 983545007522 substrate binding site [chemical binding]; other site 983545007523 dimer interface [polypeptide binding]; other site 983545007524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545007526 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545007527 putative effector binding pocket; other site 983545007528 dimerization interface [polypeptide binding]; other site 983545007529 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 983545007530 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 983545007531 phosphate binding site [ion binding]; other site 983545007532 putative substrate binding pocket [chemical binding]; other site 983545007533 dimer interface [polypeptide binding]; other site 983545007534 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 983545007535 signal recognition particle protein; Provisional; Region: PRK10867 983545007536 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 983545007537 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 983545007538 P loop; other site 983545007539 GTP binding site [chemical binding]; other site 983545007540 Signal peptide binding domain; Region: SRP_SPB; pfam02978 983545007541 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 983545007542 hypothetical protein; Provisional; Region: PRK11573 983545007543 Domain of unknown function DUF21; Region: DUF21; pfam01595 983545007544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 983545007545 Transporter associated domain; Region: CorC_HlyC; pfam03471 983545007546 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 983545007547 catalytic core [active] 983545007548 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 983545007549 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545007550 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545007551 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 983545007552 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 983545007553 PAS fold; Region: PAS_3; pfam08447 983545007554 PAS domain S-box; Region: sensory_box; TIGR00229 983545007555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545007556 putative active site [active] 983545007557 heme pocket [chemical binding]; other site 983545007558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007559 metal binding site [ion binding]; metal-binding site 983545007560 active site 983545007561 I-site; other site 983545007562 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545007563 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545007564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545007565 substrate binding site [chemical binding]; other site 983545007566 oxyanion hole (OAH) forming residues; other site 983545007567 trimer interface [polypeptide binding]; other site 983545007568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007569 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545007570 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 983545007571 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545007572 dimer interface [polypeptide binding]; other site 983545007573 active site 983545007574 MoxR-like ATPases [General function prediction only]; Region: COG0714 983545007575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545007576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545007577 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 983545007578 Protein of unknown function DUF58; Region: DUF58; pfam01882 983545007579 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 983545007580 metal ion-dependent adhesion site (MIDAS); other site 983545007581 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545007582 metal ion-dependent adhesion site (MIDAS); other site 983545007583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 983545007584 RNA polymerase sigma factor; Provisional; Region: PRK12517 983545007585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545007586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 983545007587 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 983545007588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545007589 Sodium:solute symporter family; Region: SSF; cl00456 983545007590 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 983545007591 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 983545007592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545007593 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 983545007594 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983545007595 Active Sites [active] 983545007596 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 983545007597 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 983545007598 ligand-binding site [chemical binding]; other site 983545007599 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 983545007600 active site 983545007601 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 983545007602 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 983545007603 CysD dimerization site [polypeptide binding]; other site 983545007604 G1 box; other site 983545007605 putative GEF interaction site [polypeptide binding]; other site 983545007606 GTP/Mg2+ binding site [chemical binding]; other site 983545007607 Switch I region; other site 983545007608 G2 box; other site 983545007609 G3 box; other site 983545007610 Switch II region; other site 983545007611 G4 box; other site 983545007612 G5 box; other site 983545007613 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 983545007614 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 983545007615 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545007616 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545007617 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545007618 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545007619 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 983545007620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545007621 RNA binding surface [nucleotide binding]; other site 983545007622 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 983545007623 probable active site [active] 983545007624 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983545007625 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 983545007626 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 983545007627 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983545007628 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 983545007629 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 983545007630 A bacterial subgroup of the Peptidase M14-like domain of Nna-1 (Nervous system Nuclear protein induced by Axotomy), also known as ATP/GTP binding protein (AGTPBP-1) and cytosolic carboxypeptidase (CCP)-like proteins. The Peptidase M14 family of...; Region: M14_Nna1_like_1; cd06234 983545007631 putative active site [active] 983545007632 Zn-binding site [ion binding]; other site 983545007633 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 983545007634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007635 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983545007636 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 983545007637 SelR domain; Region: SelR; cl00369 983545007638 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 983545007639 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 983545007640 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545007641 glycogen branching enzyme; Provisional; Region: PRK05402 983545007642 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 983545007643 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545007644 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 983545007645 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 983545007646 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 983545007647 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 983545007648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007649 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 983545007650 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 983545007651 active site 983545007652 phosphate binding residues; other site 983545007653 catalytic residues [active] 983545007654 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 983545007655 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 983545007656 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 983545007657 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 983545007658 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 983545007659 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 983545007660 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 983545007661 putative nucleic acid binding region [nucleotide binding]; other site 983545007662 G-X-X-G motif; other site 983545007663 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 983545007664 RNA binding site [nucleotide binding]; other site 983545007665 domain interface; other site 983545007666 Pectinacetylesterase; Region: PAE; pfam03283 983545007667 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 983545007668 active site 983545007669 DNA recombination protein RmuC; Provisional; Region: PRK10361 983545007670 RmuC family; Region: RmuC; pfam02646 983545007671 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 983545007672 Fumarase C-terminus; Region: Fumerase_C; cl00795 983545007673 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 983545007674 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 983545007675 chorismate binding enzyme; Region: Chorismate_bind; cl10555 983545007676 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 983545007677 putative active site [active] 983545007678 putative CoA binding site [chemical binding]; other site 983545007679 nudix motif; other site 983545007680 metal binding site [ion binding]; metal-binding site 983545007681 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 983545007682 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 983545007683 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 983545007684 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 983545007685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545007686 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 983545007687 substrate binding site [chemical binding]; other site 983545007688 dimerization interface [polypeptide binding]; other site 983545007689 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 983545007690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007691 ATP binding site [chemical binding]; other site 983545007692 Mg2+ binding site [ion binding]; other site 983545007693 G-X-G motif; other site 983545007694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545007695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545007696 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 983545007697 putative dimerization interface [polypeptide binding]; other site 983545007698 Coenzyme A transferase; Region: CoA_trans; cl00773 983545007699 Coenzyme A transferase; Region: CoA_trans; cl00773 983545007700 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 983545007701 DEAD-like helicases superfamily; Region: DEXDc; smart00487 983545007702 ATP binding site [chemical binding]; other site 983545007703 Mg++ binding site [ion binding]; other site 983545007704 motif III; other site 983545007705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545007706 nucleotide binding region [chemical binding]; other site 983545007707 ATP-binding site [chemical binding]; other site 983545007708 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 983545007709 putative FMN binding site [chemical binding]; other site 983545007710 DoxX; Region: DoxX; cl00976 983545007711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545007712 active site 983545007713 motif I; other site 983545007714 motif II; other site 983545007715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 983545007716 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 983545007717 active site 983545007718 dinuclear metal binding site [ion binding]; other site 983545007719 dimerization interface [polypeptide binding]; other site 983545007720 Yip1 domain; Region: Yip1; cl12048 983545007721 amidophosphoribosyltransferase; Provisional; Region: PRK09246 983545007722 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 983545007723 active site 983545007724 tetramer interface [polypeptide binding]; other site 983545007725 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 983545007726 Colicin V production protein; Region: Colicin_V; cl00567 983545007727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 983545007728 Sporulation related domain; Region: SPOR; cl10051 983545007729 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 983545007730 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 983545007731 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 983545007732 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 983545007733 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 983545007734 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 983545007735 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 983545007736 dimerization interface 3.5A [polypeptide binding]; other site 983545007737 active site 983545007738 response regulator GlrR; Provisional; Region: PRK15115 983545007739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007740 active site 983545007741 phosphorylation site [posttranslational modification] 983545007742 intermolecular recognition site; other site 983545007743 dimerization interface [polypeptide binding]; other site 983545007744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545007745 Walker A motif; other site 983545007746 ATP binding site [chemical binding]; other site 983545007747 Walker B motif; other site 983545007748 arginine finger; other site 983545007749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545007750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007751 ATP binding site [chemical binding]; other site 983545007752 Mg2+ binding site [ion binding]; other site 983545007753 G-X-G motif; other site 983545007754 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 983545007755 putative metal binding site [ion binding]; other site 983545007756 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 983545007757 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 983545007758 Walker A/P-loop; other site 983545007759 ATP binding site [chemical binding]; other site 983545007760 Q-loop/lid; other site 983545007761 ABC transporter signature motif; other site 983545007762 Walker B; other site 983545007763 D-loop; other site 983545007764 H-loop/switch region; other site 983545007765 TOBE domain; Region: TOBE_2; cl01440 983545007766 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 983545007767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545007768 dimer interface [polypeptide binding]; other site 983545007769 conserved gate region; other site 983545007770 putative PBP binding loops; other site 983545007771 ABC-ATPase subunit interface; other site 983545007772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 983545007773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545007774 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 983545007775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545007776 Coenzyme A binding pocket [chemical binding]; other site 983545007777 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007779 active site 983545007780 phosphorylation site [posttranslational modification] 983545007781 intermolecular recognition site; other site 983545007782 dimerization interface [polypeptide binding]; other site 983545007783 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 983545007784 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 983545007785 anti sigma factor interaction site; other site 983545007786 regulatory phosphorylation site [posttranslational modification]; other site 983545007787 translation initiation factor Sui1; Validated; Region: PRK06824 983545007788 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 983545007789 Predicted RNA interaction site [nucleotide binding]; other site 983545007790 putative binding site; other site 983545007791 Mutations affecting start-site selection; other site 983545007792 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007794 active site 983545007795 phosphorylation site [posttranslational modification] 983545007796 intermolecular recognition site; other site 983545007797 dimerization interface [polypeptide binding]; other site 983545007798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007799 active site 983545007800 phosphorylation site [posttranslational modification] 983545007801 intermolecular recognition site; other site 983545007802 dimerization interface [polypeptide binding]; other site 983545007803 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 983545007804 Chorismate mutase type II; Region: CM_2; cl00693 983545007805 Prephenate dehydratase; Region: PDT; pfam00800 983545007806 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 983545007807 putative L-Phe binding site [chemical binding]; other site 983545007808 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 983545007809 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 983545007810 Chorismate mutase type II; Region: CM_2; cl00693 983545007811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545007812 NeuB family; Region: NeuB; cl00496 983545007813 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 983545007814 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 983545007815 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545007816 active site 983545007817 Zn binding site [ion binding]; other site 983545007818 maltose O-acetyltransferase; Provisional; Region: PRK10092 983545007819 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 983545007820 active site 983545007821 substrate binding site [chemical binding]; other site 983545007822 trimer interface [polypeptide binding]; other site 983545007823 CoA binding site [chemical binding]; other site 983545007824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545007825 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 983545007826 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 983545007827 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 983545007828 DNA binding residues [nucleotide binding] 983545007829 dimer interface [polypeptide binding]; other site 983545007830 [2Fe-2S] cluster binding site [ion binding]; other site 983545007831 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545007832 active site 983545007833 metal binding site [ion binding]; metal-binding site 983545007834 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 983545007835 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 983545007836 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 983545007837 RimM N-terminal domain; Region: RimM; pfam01782 983545007838 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 983545007839 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 983545007840 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 983545007841 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 983545007842 Walker A/P-loop; other site 983545007843 ATP binding site [chemical binding]; other site 983545007844 Q-loop/lid; other site 983545007845 ABC transporter signature motif; other site 983545007846 Walker B; other site 983545007847 D-loop; other site 983545007848 H-loop/switch region; other site 983545007849 Preprotein translocase SecG subunit; Region: SecG; cl09123 983545007850 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 983545007851 substrate binding site [chemical binding]; other site 983545007852 dimer interface [polypeptide binding]; other site 983545007853 catalytic triad [active] 983545007854 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 983545007855 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 983545007856 active site 983545007857 substrate binding site [chemical binding]; other site 983545007858 metal binding site [ion binding]; metal-binding site 983545007859 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 983545007860 dihydropteroate synthase; Region: DHPS; TIGR01496 983545007861 substrate binding pocket [chemical binding]; other site 983545007862 dimer interface [polypeptide binding]; other site 983545007863 inhibitor binding site; inhibition site 983545007864 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 983545007865 FtsH Extracellular; Region: FtsH_ext; pfam06480 983545007866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545007867 Walker A motif; other site 983545007868 ATP binding site [chemical binding]; other site 983545007869 Walker B motif; other site 983545007870 arginine finger; other site 983545007871 Peptidase family M41; Region: Peptidase_M41; pfam01434 983545007872 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2933 983545007873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545007874 S-adenosylmethionine binding site [chemical binding]; other site 983545007875 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 983545007876 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545007877 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 983545007878 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 983545007879 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 983545007880 hydrophobic ligand binding site; other site 983545007881 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 983545007882 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 983545007883 HIGH motif; other site 983545007884 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545007885 active site 983545007886 KMSKS motif; other site 983545007887 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 983545007888 tRNA binding surface [nucleotide binding]; other site 983545007889 Lipopolysaccharide-assembly; Region: LptE; cl01125 983545007890 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 983545007891 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 983545007892 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 983545007893 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 983545007894 active site 983545007895 (T/H)XGH motif; other site 983545007896 Domain of unknown function DUF143; Region: DUF143; cl00519 983545007897 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 983545007898 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 983545007899 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 983545007900 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 983545007901 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 983545007902 lytic murein transglycosylase; Region: MltB_2; TIGR02283 983545007903 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545007904 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545007905 catalytic residue [active] 983545007906 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 983545007907 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 983545007908 Sporulation related domain; Region: SPOR; cl10051 983545007909 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 983545007910 Beta-lactamase; Region: Beta-lactamase; cl01009 983545007911 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 983545007912 Protein of unknown function (DUF493); Region: DUF493; cl01102 983545007913 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 983545007914 lipoyl synthase; Provisional; Region: PRK05481 983545007915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 983545007916 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 983545007917 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545007918 metal binding site [ion binding]; metal-binding site 983545007919 active site 983545007920 I-site; other site 983545007921 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 983545007922 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 983545007923 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 983545007924 active site/substrate binding site [active] 983545007925 tetramer interface [polypeptide binding]; other site 983545007926 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 983545007927 DNA-binding site [nucleotide binding]; DNA binding site 983545007928 RNA-binding motif; other site 983545007929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545007930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545007931 putative substrate translocation pore; other site 983545007932 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 983545007933 Tetramer interface [polypeptide binding]; other site 983545007934 Active site [active] 983545007935 FMN-binding site [chemical binding]; other site 983545007936 HemK family putative methylases; Region: hemK_fam; TIGR00536 983545007937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545007938 S-adenosylmethionine binding site [chemical binding]; other site 983545007939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 983545007940 Smr domain; Region: Smr; cl02619 983545007941 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007943 active site 983545007944 phosphorylation site [posttranslational modification] 983545007945 intermolecular recognition site; other site 983545007946 dimerization interface [polypeptide binding]; other site 983545007947 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545007948 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545007949 Response regulator receiver domain; Region: Response_reg; pfam00072 983545007950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007951 active site 983545007952 phosphorylation site [posttranslational modification] 983545007953 intermolecular recognition site; other site 983545007954 dimerization interface [polypeptide binding]; other site 983545007955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545007956 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 983545007957 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 983545007958 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 983545007959 dimerization interface [polypeptide binding]; other site 983545007960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545007961 dimer interface [polypeptide binding]; other site 983545007962 phosphorylation site [posttranslational modification] 983545007963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007964 ATP binding site [chemical binding]; other site 983545007965 Mg2+ binding site [ion binding]; other site 983545007966 G-X-G motif; other site 983545007967 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 983545007968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007969 active site 983545007970 phosphorylation site [posttranslational modification] 983545007971 intermolecular recognition site; other site 983545007972 dimerization interface [polypeptide binding]; other site 983545007973 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 983545007974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545007975 dimer interface [polypeptide binding]; other site 983545007976 phosphorylation site [posttranslational modification] 983545007977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007978 ATP binding site [chemical binding]; other site 983545007979 Mg2+ binding site [ion binding]; other site 983545007980 G-X-G motif; other site 983545007981 Heme NO binding; Region: HNOB; pfam07700 983545007982 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 983545007983 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 983545007984 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545007985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545007986 dimer interface [polypeptide binding]; other site 983545007987 phosphorylation site [posttranslational modification] 983545007988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545007989 ATP binding site [chemical binding]; other site 983545007990 Mg2+ binding site [ion binding]; other site 983545007991 G-X-G motif; other site 983545007992 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 983545007993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545007994 active site 983545007995 phosphorylation site [posttranslational modification] 983545007996 intermolecular recognition site; other site 983545007997 dimerization interface [polypeptide binding]; other site 983545007998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545007999 DNA binding site [nucleotide binding] 983545008000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545008001 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 983545008002 dimer interface [polypeptide binding]; other site 983545008003 ADP-ribose binding site [chemical binding]; other site 983545008004 active site 983545008005 nudix motif; other site 983545008006 metal binding site [ion binding]; metal-binding site 983545008007 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 983545008008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 983545008009 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545008010 FecR protein; Region: FecR; pfam04773 983545008011 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545008012 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545008013 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545008014 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 983545008015 active site 983545008016 Zn-binding site [ion binding]; other site 983545008017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008018 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 983545008019 hypothetical protein; Provisional; Region: PRK10039 983545008020 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 983545008021 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 983545008022 FtsX-like permease family; Region: FtsX; pfam02687 983545008023 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 983545008024 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 983545008025 Walker A/P-loop; other site 983545008026 ATP binding site [chemical binding]; other site 983545008027 Q-loop/lid; other site 983545008028 ABC transporter signature motif; other site 983545008029 Walker B; other site 983545008030 D-loop; other site 983545008031 H-loop/switch region; other site 983545008032 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545008033 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_1; cd06251 983545008034 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 983545008035 putative active site [active] 983545008036 Zn-binding site [ion binding]; other site 983545008037 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 983545008038 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545008039 choline dehydrogenase; Validated; Region: PRK02106 983545008040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545008041 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545008042 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 983545008043 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545008044 Membrane transport protein; Region: Mem_trans; cl09117 983545008045 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 983545008046 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545008047 active site 983545008048 Zn binding site [ion binding]; other site 983545008049 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 983545008050 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 983545008051 metal binding site [ion binding]; metal-binding site 983545008052 putative dimer interface [polypeptide binding]; other site 983545008053 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 983545008054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008056 dimerization interface [polypeptide binding]; other site 983545008057 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 983545008058 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 983545008059 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 983545008060 active site 983545008061 Anti-sigma-K factor rskA; Region: RskA; cl02208 983545008062 RNA polymerase sigma factor; Provisional; Region: PRK12514 983545008063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545008064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 983545008065 DNA binding residues [nucleotide binding] 983545008066 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 983545008067 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 983545008068 Ligand binding site [chemical binding]; other site 983545008069 DXD motif; other site 983545008070 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl01208 983545008071 fatty acid metabolism regulator; Provisional; Region: PRK04984 983545008072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545008073 DNA-binding site [nucleotide binding]; DNA binding site 983545008074 FCD domain; Region: FCD; cl11656 983545008075 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545008076 transmembrane helices; other site 983545008077 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 983545008078 Amidinotransferase; Region: Amidinotransf; cl12043 983545008079 ornithine cyclodeaminase; Validated; Region: PRK07589 983545008080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008082 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 983545008083 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 983545008084 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 983545008085 Flagellin N-methylase; Region: FliB; cl00497 983545008086 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545008087 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 983545008088 lytic murein transglycosylase; Region: MltB_2; TIGR02283 983545008089 YcgL domain; Region: YcgL; cl01189 983545008090 ribonuclease D; Provisional; Region: PRK10829 983545008091 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 983545008092 putative active site [active] 983545008093 catalytic site [active] 983545008094 putative substrate binding site [chemical binding]; other site 983545008095 HRDC domain; Region: HRDC; cl02578 983545008096 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 983545008097 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545008098 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545008099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 983545008100 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 983545008101 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 983545008102 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 983545008103 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 983545008104 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545008105 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545008106 Flagellar L-ring protein; Region: FlgH; cl00905 983545008107 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 983545008108 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 983545008109 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 983545008110 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 983545008111 oxidoreductase; Provisional; Region: PRK06128 983545008112 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 983545008113 NAD binding site [chemical binding]; other site 983545008114 metal binding site [ion binding]; metal-binding site 983545008115 active site 983545008116 methionine aminopeptidase; Reviewed; Region: PRK07281 983545008117 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 983545008118 active site 983545008119 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 983545008120 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 983545008121 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 983545008122 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 983545008123 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 983545008124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545008125 dimer interface [polypeptide binding]; other site 983545008126 phosphorylation site [posttranslational modification] 983545008127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008128 ATP binding site [chemical binding]; other site 983545008129 Mg2+ binding site [ion binding]; other site 983545008130 G-X-G motif; other site 983545008131 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545008132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545008133 active site 983545008134 phosphorylation site [posttranslational modification] 983545008135 intermolecular recognition site; other site 983545008136 dimerization interface [polypeptide binding]; other site 983545008137 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545008139 active site 983545008140 phosphorylation site [posttranslational modification] 983545008141 intermolecular recognition site; other site 983545008142 dimerization interface [polypeptide binding]; other site 983545008143 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 983545008144 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 983545008145 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 983545008146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008148 dimerization interface [polypeptide binding]; other site 983545008149 LysE type translocator; Region: LysE; cl00565 983545008150 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 983545008151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545008152 RNA binding surface [nucleotide binding]; other site 983545008153 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 983545008154 probable active site [active] 983545008155 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 983545008156 ScpA/B protein; Region: ScpA_ScpB; cl00598 983545008157 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 983545008158 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 983545008159 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 983545008160 anthranilate synthase component I; Provisional; Region: PRK13564 983545008161 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 983545008162 chorismate binding enzyme; Region: Chorismate_bind; cl10555 983545008163 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 983545008164 Glutamine amidotransferase class-I; Region: GATase; pfam00117 983545008165 glutamine binding [chemical binding]; other site 983545008166 catalytic triad [active] 983545008167 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 983545008168 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 983545008169 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 983545008170 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 983545008171 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 983545008172 active site 983545008173 ribulose/triose binding site [chemical binding]; other site 983545008174 phosphate binding site [ion binding]; other site 983545008175 substrate (anthranilate) binding pocket [chemical binding]; other site 983545008176 product (indole) binding pocket [chemical binding]; other site 983545008177 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 983545008178 active site 983545008179 tryptophan synthase, beta chain; Region: PLN02618 983545008180 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 983545008181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545008182 catalytic residue [active] 983545008183 tryptophan synthase; Region: PLN02591 983545008184 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 983545008185 substrate binding site [chemical binding]; other site 983545008186 active site 983545008187 catalytic residues [active] 983545008188 heterodimer interface [polypeptide binding]; other site 983545008189 YCII-related domain; Region: YCII; cl00999 983545008190 RF-1 domain; Region: RF-1; cl02875 983545008191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545008192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545008193 active site 983545008194 phosphorylation site [posttranslational modification] 983545008195 intermolecular recognition site; other site 983545008196 dimerization interface [polypeptide binding]; other site 983545008197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545008198 DNA binding site [nucleotide binding] 983545008199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 983545008200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008201 ATP binding site [chemical binding]; other site 983545008202 Mg2+ binding site [ion binding]; other site 983545008203 G-X-G motif; other site 983545008204 Surface antigen; Region: Surface_Ag_2; cl01155 983545008205 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008207 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008208 putative effector binding pocket; other site 983545008209 dimerization interface [polypeptide binding]; other site 983545008210 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 983545008211 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545008212 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 983545008213 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 983545008214 putative molybdopterin cofactor binding site [chemical binding]; other site 983545008215 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 983545008216 putative molybdopterin cofactor binding site; other site 983545008217 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 983545008218 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 983545008219 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 983545008220 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 983545008221 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 983545008222 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545008223 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 983545008224 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545008225 N-terminal plug; other site 983545008226 ligand-binding site [chemical binding]; other site 983545008227 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes...; Region: Topo_IB_C; cd00659 983545008228 DNA binding site [nucleotide binding] 983545008229 active site 983545008230 Int/Topo IB signature motif; other site 983545008231 catalytic residues [active] 983545008232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545008233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545008234 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 983545008235 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545008236 putative NAD(P) binding site [chemical binding]; other site 983545008237 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 983545008238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008239 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545008240 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545008241 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 983545008242 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 983545008243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545008244 DNA-binding site [nucleotide binding]; DNA binding site 983545008245 UTRA domain; Region: UTRA; cl06649 983545008246 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 983545008247 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545008248 Walker A/P-loop; other site 983545008249 ATP binding site [chemical binding]; other site 983545008250 Q-loop/lid; other site 983545008251 ABC transporter signature motif; other site 983545008252 Walker B; other site 983545008253 D-loop; other site 983545008254 H-loop/switch region; other site 983545008255 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 983545008256 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545008257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545008258 Walker A/P-loop; other site 983545008259 ATP binding site [chemical binding]; other site 983545008260 Q-loop/lid; other site 983545008261 ABC transporter signature motif; other site 983545008262 Walker B; other site 983545008263 D-loop; other site 983545008264 H-loop/switch region; other site 983545008265 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 983545008266 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 983545008267 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 983545008268 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 983545008269 LysE type translocator; Region: LysE; cl00565 983545008270 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 983545008271 active site 983545008272 metal binding site [ion binding]; metal-binding site 983545008273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008274 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 983545008275 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 983545008276 heme-binding residues [chemical binding]; other site 983545008277 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 983545008278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545008279 TPR motif; other site 983545008280 binding surface 983545008281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545008282 binding surface 983545008283 TPR motif; other site 983545008284 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 983545008285 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 983545008286 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 983545008287 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545008288 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 983545008289 maleylacetoacetate isomerase; Region: maiA; TIGR01262 983545008290 C-terminal domain interface [polypeptide binding]; other site 983545008291 GSH binding site (G-site) [chemical binding]; other site 983545008292 putative dimer interface [polypeptide binding]; other site 983545008293 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 983545008294 N-terminal domain interface [polypeptide binding]; other site 983545008295 dimer interface [polypeptide binding]; other site 983545008296 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 983545008297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008298 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 983545008299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008300 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 983545008301 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545008302 Cupin domain; Region: Cupin_2; cl09118 983545008303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545008304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545008305 Cupin domain; Region: Cupin_2; cl09118 983545008306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008308 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008309 putative effector binding pocket; other site 983545008310 dimerization interface [polypeptide binding]; other site 983545008311 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 983545008312 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 983545008313 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545008314 domain; Region: Glyco_hydro_2; pfam00703 983545008315 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 983545008316 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 983545008317 Predicted esterase [General function prediction only]; Region: COG0627 983545008318 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545008319 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 983545008320 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 983545008321 substrate binding site [chemical binding]; other site 983545008322 catalytic Zn binding site [ion binding]; other site 983545008323 NAD binding site [chemical binding]; other site 983545008324 structural Zn binding site [ion binding]; other site 983545008325 dimer interface [polypeptide binding]; other site 983545008326 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 983545008327 LysR family transcriptional regulator; Provisional; Region: PRK14997 983545008328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008329 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 983545008330 putative effector binding pocket; other site 983545008331 putative dimerization interface [polypeptide binding]; other site 983545008332 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 983545008333 active site 983545008334 metal binding site [ion binding]; metal-binding site 983545008335 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 983545008336 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 983545008337 active site 983545008338 FMN binding site [chemical binding]; other site 983545008339 substrate binding site [chemical binding]; other site 983545008340 3Fe-4S cluster binding site [ion binding]; other site 983545008341 Uncharacterized conserved protein [Function unknown]; Region: COG2966 983545008342 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 983545008343 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 983545008344 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983545008345 classical (c) SDRs; Region: SDR_c; cd05233 983545008346 NAD(P) binding site [chemical binding]; other site 983545008347 active site 983545008348 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 983545008349 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 983545008350 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 983545008351 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 983545008352 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 983545008353 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 983545008354 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 983545008355 putative NAD(P) binding site [chemical binding]; other site 983545008356 putative substrate binding site [chemical binding]; other site 983545008357 catalytic Zn binding site [ion binding]; other site 983545008358 structural Zn binding site [ion binding]; other site 983545008359 dimer interface [polypeptide binding]; other site 983545008360 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 983545008361 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545008362 FMN binding site [chemical binding]; other site 983545008363 active site 983545008364 substrate binding site [chemical binding]; other site 983545008365 catalytic residue [active] 983545008366 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008367 metal binding site [ion binding]; metal-binding site 983545008368 active site 983545008369 I-site; other site 983545008370 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545008371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545008372 putative substrate translocation pore; other site 983545008373 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 983545008374 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 983545008375 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 983545008376 substrate binding site [chemical binding]; other site 983545008377 ligand binding site [chemical binding]; other site 983545008378 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 983545008379 substrate binding site [chemical binding]; other site 983545008380 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 983545008381 dimer interface [polypeptide binding]; other site 983545008382 Citrate synthase; Region: Citrate_synt; pfam00285 983545008383 active site 983545008384 citrylCoA binding site [chemical binding]; other site 983545008385 oxalacetate/citrate binding site [chemical binding]; other site 983545008386 coenzyme A binding site [chemical binding]; other site 983545008387 catalytic triad [active] 983545008388 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 983545008389 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545008390 tetramer interface [polypeptide binding]; other site 983545008391 active site 983545008392 Mg2+/Mn2+ binding site [ion binding]; other site 983545008393 Transcriptional regulators [Transcription]; Region: GntR; COG1802 983545008394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545008395 DNA-binding site [nucleotide binding]; DNA binding site 983545008396 FCD domain; Region: FCD; cl11656 983545008397 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 983545008398 putative S-transferase; Provisional; Region: PRK11752 983545008399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545008400 Sulfatase; Region: Sulfatase; cl10460 983545008401 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545008402 Sulfatase; Region: Sulfatase; cl10460 983545008403 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545008404 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545008405 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545008406 ligand-binding site [chemical binding]; other site 983545008407 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 983545008408 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 983545008409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545008410 active site 983545008411 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 983545008412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008413 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 983545008414 NAD(P) binding site [chemical binding]; other site 983545008415 active site 983545008416 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 983545008417 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 983545008418 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 983545008419 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545008420 Protein of unknown function, DUF599; Region: DUF599; cl01575 983545008421 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 983545008422 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 983545008423 dimer interface [polypeptide binding]; other site 983545008424 active site 983545008425 metal binding site [ion binding]; metal-binding site 983545008426 glutathione binding site [chemical binding]; other site 983545008427 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 983545008428 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 983545008429 active site 983545008430 catalytic site [active] 983545008431 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545008432 ligand binding site [chemical binding]; other site 983545008433 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 983545008434 active site 983545008435 catalytic site [active] 983545008436 substrate binding site [chemical binding]; other site 983545008437 peroxidase; Provisional; Region: PRK15000 983545008438 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 983545008439 dimer interface [polypeptide binding]; other site 983545008440 decamer (pentamer of dimers) interface [polypeptide binding]; other site 983545008441 catalytic triad [active] 983545008442 peroxidatic and resolving cysteines [active] 983545008443 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 983545008444 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 983545008445 putative GSH binding site [chemical binding]; other site 983545008446 catalytic residues [active] 983545008447 superoxide dismutase; Provisional; Region: PRK10543 983545008448 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 983545008449 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 983545008450 PrkA family serine protein kinase; Provisional; Region: PRK15455 983545008451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545008452 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 983545008453 Protein of unknown function (DUF444); Region: DUF444; pfam04285 983545008454 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545008455 SpoVR family protein; Provisional; Region: PRK11767 983545008456 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 983545008457 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 983545008458 Protein of unknown function DUF45; Region: DUF45; cl00636 983545008459 Uncharacterised protein family (UPF0231); Region: UPF0231; cl11474 983545008460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 983545008461 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 983545008462 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545008463 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545008464 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545008465 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545008466 Domain of unknown function (DUF336); Region: DUF336; cl01249 983545008467 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 983545008468 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 983545008469 active site 983545008470 catalytic tetrad [active] 983545008471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008473 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008474 putative effector binding pocket; other site 983545008475 dimerization interface [polypeptide binding]; other site 983545008476 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 983545008477 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 983545008478 active site 983545008479 FMN binding site [chemical binding]; other site 983545008480 2,4-decadienoyl-CoA binding site; other site 983545008481 catalytic residue [active] 983545008482 4Fe-4S cluster binding site [ion binding]; other site 983545008483 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 983545008484 enoyl-CoA hydratase; Provisional; Region: PRK06142 983545008485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545008486 substrate binding site [chemical binding]; other site 983545008487 oxyanion hole (OAH) forming residues; other site 983545008488 trimer interface [polypeptide binding]; other site 983545008489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545008490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545008491 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 983545008492 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545008493 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545008494 Domain of unknown function (DU1801); Region: DUF1801; cl01838 983545008495 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545008496 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545008497 catalytic residue [active] 983545008498 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 983545008499 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983545008500 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545008501 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545008502 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 983545008503 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 983545008504 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 983545008505 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545008506 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 983545008507 active site 983545008508 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 983545008509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008510 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 983545008511 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 983545008512 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 983545008513 dimer interface [polypeptide binding]; other site 983545008514 putative anticodon binding site; other site 983545008515 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 983545008516 motif 1; other site 983545008517 active site 983545008518 motif 2; other site 983545008519 motif 3; other site 983545008520 peptide chain release factor 2; Validated; Region: prfB; PRK00578 983545008521 RF-1 domain; Region: RF-1; cl02875 983545008522 RF-1 domain; Region: RF-1; cl02875 983545008523 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 983545008524 arginine-tRNA ligase; Region: PLN02286 983545008525 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 983545008526 active site 983545008527 HIGH motif; other site 983545008528 KMSK motif region; other site 983545008529 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 983545008530 tRNA binding surface [nucleotide binding]; other site 983545008531 anticodon binding site; other site 983545008532 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 983545008533 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 983545008534 G1 box; other site 983545008535 putative GEF interaction site [polypeptide binding]; other site 983545008536 GTP/Mg2+ binding site [chemical binding]; other site 983545008537 Switch I region; other site 983545008538 G2 box; other site 983545008539 G3 box; other site 983545008540 Switch II region; other site 983545008541 G4 box; other site 983545008542 G5 box; other site 983545008543 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 983545008544 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 983545008545 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545008546 putative NAD(P) binding site [chemical binding]; other site 983545008547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008549 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545008550 putative effector binding pocket; other site 983545008551 dimerization interface [polypeptide binding]; other site 983545008552 Protein of unknown function (DUF465); Region: DUF465; cl01070 983545008553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008554 NAD(P) binding site [chemical binding]; other site 983545008555 active site 983545008556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545008557 non-specific DNA binding site [nucleotide binding]; other site 983545008558 salt bridge; other site 983545008559 sequence-specific DNA binding site [nucleotide binding]; other site 983545008560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545008561 non-specific DNA binding site [nucleotide binding]; other site 983545008562 salt bridge; other site 983545008563 sequence-specific DNA binding site [nucleotide binding]; other site 983545008564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008565 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 983545008566 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 983545008567 active site 983545008568 substrate binding site [chemical binding]; other site 983545008569 ATP binding site [chemical binding]; other site 983545008570 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 983545008571 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545008572 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545008573 N-terminal plug; other site 983545008574 ligand-binding site [chemical binding]; other site 983545008575 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 983545008576 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 983545008577 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 983545008578 Putative ATPase (DUF699); Region: DUF699; pfam05127 983545008579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 983545008580 Coenzyme A binding pocket [chemical binding]; other site 983545008581 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 983545008582 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 983545008583 active site 983545008584 catalytic triad [active] 983545008585 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 983545008586 PA/protease or protease-like domain interface [polypeptide binding]; other site 983545008587 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 983545008588 catalytic residues [active] 983545008589 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 983545008590 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 983545008591 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545008592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545008593 binding surface 983545008594 TPR motif; other site 983545008595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545008596 binding surface 983545008597 TPR motif; other site 983545008598 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 983545008599 Clp amino terminal domain; Region: Clp_N; pfam02861 983545008600 Clp amino terminal domain; Region: Clp_N; pfam02861 983545008601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545008602 Walker A motif; other site 983545008603 ATP binding site [chemical binding]; other site 983545008604 Walker B motif; other site 983545008605 arginine finger; other site 983545008606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545008607 Walker A motif; other site 983545008608 ATP binding site [chemical binding]; other site 983545008609 Walker B motif; other site 983545008610 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 983545008611 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 983545008612 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 983545008613 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 983545008614 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545008615 RNA binding surface [nucleotide binding]; other site 983545008616 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 983545008617 active site 983545008618 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 983545008619 Transcriptional activator [Transcription]; Region: ChrR; COG3806 983545008620 Cupin domain; Region: Cupin_2; cl09118 983545008621 RNA polymerase sigma factor; Provisional; Region: PRK11924 983545008622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545008623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 983545008624 DNA binding residues [nucleotide binding] 983545008625 Found in ATP-dependent protease La (LON); Region: LON; cl01056 983545008626 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 983545008627 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545008628 short chain dehydrogenase; Provisional; Region: PRK06101 983545008629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008630 NAD(P) binding site [chemical binding]; other site 983545008631 active site 983545008632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545008633 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 983545008634 Protein of unknown function (DUF1365); Region: DUF1365; cl01388 983545008635 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 983545008636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545008637 S-adenosylmethionine binding site [chemical binding]; other site 983545008638 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 983545008639 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 983545008640 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545008641 ligand binding site [chemical binding]; other site 983545008642 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545008643 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 983545008644 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 983545008645 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 983545008646 substrate binding pocket [chemical binding]; other site 983545008647 chain length determination region; other site 983545008648 substrate-Mg2+ binding site; other site 983545008649 catalytic residues [active] 983545008650 aspartate-rich region 1; other site 983545008651 active site lid residues [active] 983545008652 aspartate-rich region 2; other site 983545008653 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 983545008654 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 983545008655 TPP-binding site; other site 983545008656 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 983545008657 PYR/PP interface [polypeptide binding]; other site 983545008658 dimer interface [polypeptide binding]; other site 983545008659 TPP binding site [chemical binding]; other site 983545008660 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 983545008661 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 983545008662 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 983545008663 tetramer interfaces [polypeptide binding]; other site 983545008664 binuclear metal-binding site [ion binding]; other site 983545008665 thiamine monophosphate kinase; Provisional; Region: PRK05731 983545008666 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 983545008667 ATP binding site [chemical binding]; other site 983545008668 dimerization interface [polypeptide binding]; other site 983545008669 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 983545008670 putative RNA binding site [nucleotide binding]; other site 983545008671 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 983545008672 homopentamer interface [polypeptide binding]; other site 983545008673 active site 983545008674 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 983545008675 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 983545008676 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 983545008677 dimerization interface [polypeptide binding]; other site 983545008678 active site 983545008679 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 983545008680 Lumazine binding domain; Region: Lum_binding; pfam00677 983545008681 Lumazine binding domain; Region: Lum_binding; pfam00677 983545008682 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 983545008683 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 983545008684 catalytic motif [active] 983545008685 Zn binding site [ion binding]; other site 983545008686 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 983545008687 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 983545008688 ATP cone domain; Region: ATP-cone; pfam03477 983545008689 Sporulation related domain; Region: SPOR; cl10051 983545008690 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 983545008691 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 983545008692 Predicted integral membrane protein [Function unknown]; Region: COG5616 983545008693 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 983545008694 dimer interface [polypeptide binding]; other site 983545008695 glycine-pyridoxal phosphate binding site [chemical binding]; other site 983545008696 active site 983545008697 folate binding site [chemical binding]; other site 983545008698 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545008699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008700 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 983545008701 hypothetical protein; Provisional; Region: PRK07338 983545008702 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 983545008703 metal binding site [ion binding]; metal-binding site 983545008704 dimer interface [polypeptide binding]; other site 983545008705 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 983545008706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545008707 Walker A/P-loop; other site 983545008708 ATP binding site [chemical binding]; other site 983545008709 Q-loop/lid; other site 983545008710 ABC transporter signature motif; other site 983545008711 Walker B; other site 983545008712 D-loop; other site 983545008713 H-loop/switch region; other site 983545008714 ABC transporter; Region: ABC_tran_2; pfam12848 983545008715 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 983545008716 PAS fold; Region: PAS_4; pfam08448 983545008717 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 983545008718 GAF domain; Region: GAF; cl00853 983545008719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545008720 heme pocket [chemical binding]; other site 983545008721 putative active site [active] 983545008722 GAF domain; Region: GAF; cl00853 983545008723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545008724 PAS fold; Region: PAS_3; pfam08447 983545008725 putative active site [active] 983545008726 heme pocket [chemical binding]; other site 983545008727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545008728 dimer interface [polypeptide binding]; other site 983545008729 phosphorylation site [posttranslational modification] 983545008730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545008731 ATP binding site [chemical binding]; other site 983545008732 Mg2+ binding site [ion binding]; other site 983545008733 G-X-G motif; other site 983545008734 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545008736 active site 983545008737 phosphorylation site [posttranslational modification] 983545008738 intermolecular recognition site; other site 983545008739 dimerization interface [polypeptide binding]; other site 983545008740 UbiA prenyltransferase family; Region: UbiA; cl00337 983545008741 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 983545008742 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 983545008743 Subunit I/III interface [polypeptide binding]; other site 983545008744 Subunit III/IV interface [polypeptide binding]; other site 983545008745 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545008746 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 983545008747 D-pathway; other site 983545008748 Putative ubiquinol binding site [chemical binding]; other site 983545008749 Low-spin heme (heme b) binding site [chemical binding]; other site 983545008750 Putative water exit pathway; other site 983545008751 Binuclear center (heme o3/CuB) [ion binding]; other site 983545008752 K-pathway; other site 983545008753 Putative proton exit pathway; other site 983545008754 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 983545008755 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545008756 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 983545008757 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983545008758 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545008759 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545008760 active site 983545008761 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 983545008762 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 983545008763 metal binding site [ion binding]; metal-binding site 983545008764 putative dimer interface [polypeptide binding]; other site 983545008765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545008766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545008767 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 983545008768 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 983545008769 aconitate hydratase; Validated; Region: PRK09277 983545008770 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 983545008771 substrate binding site [chemical binding]; other site 983545008772 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 983545008773 ligand binding site [chemical binding]; other site 983545008774 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 983545008775 substrate binding site [chemical binding]; other site 983545008776 Entericidin EcnA/B family; Region: Entericidin; cl02322 983545008777 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545008778 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008779 metal binding site [ion binding]; metal-binding site 983545008780 active site 983545008781 I-site; other site 983545008782 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545008783 DNA repair protein RadA; Provisional; Region: PRK11823 983545008784 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 983545008785 Walker A motif/ATP binding site; other site 983545008786 ATP binding site [chemical binding]; other site 983545008787 Walker B motif; other site 983545008788 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 983545008789 PilZ domain; Region: PilZ; cl01260 983545008790 PilZ domain; Region: PilZ; cl01260 983545008791 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 983545008792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 983545008793 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545008794 motif II; other site 983545008795 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 983545008796 homodimer interaction site [polypeptide binding]; other site 983545008797 cofactor binding site; other site 983545008798 prolyl-tRNA synthetase; Provisional; Region: PRK09194 983545008799 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 983545008800 dimer interface [polypeptide binding]; other site 983545008801 motif 1; other site 983545008802 active site 983545008803 motif 2; other site 983545008804 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 983545008805 putative deacylase active site [active] 983545008806 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 983545008807 active site 983545008808 motif 3; other site 983545008809 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 983545008810 anticodon binding site; other site 983545008811 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545008812 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 983545008813 nucleophile elbow; other site 983545008814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 983545008815 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 983545008816 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 983545008817 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 983545008818 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 983545008819 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 983545008820 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545008821 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 983545008822 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 983545008823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545008824 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 983545008825 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545008826 metal binding site [ion binding]; metal-binding site 983545008827 active site 983545008828 I-site; other site 983545008829 Response regulator receiver domain; Region: Response_reg; pfam00072 983545008830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545008831 active site 983545008832 phosphorylation site [posttranslational modification] 983545008833 intermolecular recognition site; other site 983545008834 dimerization interface [polypeptide binding]; other site 983545008835 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 983545008836 heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); Region: Ebola_HIV-1-like_HR1-HR2; cl02885 983545008837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545008840 dimerization interface [polypeptide binding]; other site 983545008841 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 983545008842 active site flap/lid [active] 983545008843 nucleophilic elbow; other site 983545008844 catalytic triad [active] 983545008845 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 983545008846 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 983545008847 Ligand Binding Site [chemical binding]; other site 983545008848 TilS substrate binding domain; Region: TilS; pfam09179 983545008849 B3/4 domain; Region: B3_4; cl11458 983545008850 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 983545008851 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 983545008852 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 983545008853 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 983545008854 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 983545008855 generic binding surface I; other site 983545008856 generic binding surface II; other site 983545008857 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 983545008858 RNA/DNA hybrid binding site [nucleotide binding]; other site 983545008859 active site 983545008860 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 983545008861 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 983545008862 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 983545008863 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 983545008864 active site 983545008865 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 983545008866 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 983545008867 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 983545008868 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 983545008869 trimer interface [polypeptide binding]; other site 983545008870 active site 983545008871 UDP-GlcNAc binding site [chemical binding]; other site 983545008872 lipid binding site [chemical binding]; lipid-binding site 983545008873 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 983545008874 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 983545008875 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 983545008876 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 983545008877 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 983545008878 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 983545008879 Surface antigen; Region: Bac_surface_Ag; cl03097 983545008880 zinc metallopeptidase RseP; Provisional; Region: PRK10779 983545008881 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 983545008882 active site 983545008883 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 983545008884 protein binding site [polypeptide binding]; other site 983545008885 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 983545008886 protein binding site [polypeptide binding]; other site 983545008887 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 983545008888 putative substrate binding region [chemical binding]; other site 983545008889 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 983545008890 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 983545008891 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 983545008892 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 983545008893 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 983545008894 catalytic residue [active] 983545008895 putative FPP diphosphate binding site; other site 983545008896 putative FPP binding hydrophobic cleft; other site 983545008897 dimer interface [polypeptide binding]; other site 983545008898 putative IPP diphosphate binding site; other site 983545008899 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 983545008900 hinge region; other site 983545008901 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 983545008902 putative nucleotide binding site [chemical binding]; other site 983545008903 uridine monophosphate binding site [chemical binding]; other site 983545008904 homohexameric interface [polypeptide binding]; other site 983545008905 elongation factor Ts; Provisional; Region: tsf; PRK09377 983545008906 Elongation factor TS; Region: EF_TS; pfam00889 983545008907 Elongation factor TS; Region: EF_TS; pfam00889 983545008908 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 983545008909 rRNA interaction site [nucleotide binding]; other site 983545008910 S8 interaction site; other site 983545008911 putative laminin-1 binding site; other site 983545008912 methionine aminopeptidase; Reviewed; Region: PRK07281 983545008913 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 983545008914 active site 983545008915 PII uridylyl-transferase; Provisional; Region: PRK05007 983545008916 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545008917 metal binding triad; other site 983545008918 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545008919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545008920 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 983545008921 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 983545008922 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 983545008923 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 983545008924 putative active site [active] 983545008925 putative metal binding site [ion binding]; other site 983545008926 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 983545008927 putative acyl-acceptor binding pocket; other site 983545008928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545008929 YebG protein; Region: YebG; cl01217 983545008930 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545008931 catalytic loop [active] 983545008932 iron binding site [ion binding]; other site 983545008933 chaperone protein HscA; Provisional; Region: hscA; PRK05183 983545008934 co-chaperone HscB; Provisional; Region: hscB; PRK05014 983545008935 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 983545008936 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 983545008937 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 983545008938 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 983545008939 trimerization site [polypeptide binding]; other site 983545008940 active site 983545008941 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 983545008942 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545008943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545008944 catalytic residue [active] 983545008945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008946 Rrf2 family protein; Region: rrf2_super; TIGR00738 983545008947 serine O-acetyltransferase; Region: cysE; TIGR01172 983545008948 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 983545008949 trimer interface [polypeptide binding]; other site 983545008950 active site 983545008951 substrate binding site [chemical binding]; other site 983545008952 CoA binding site [chemical binding]; other site 983545008953 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 983545008954 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545008955 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 983545008956 putative metal binding site [ion binding]; other site 983545008957 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 983545008958 active site 983545008959 dimerization interface [polypeptide binding]; other site 983545008960 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 983545008961 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 983545008962 Protein export membrane protein; Region: SecD_SecF; cl14618 983545008963 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 983545008964 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 983545008965 Protein export membrane protein; Region: SecD_SecF; cl14618 983545008966 Preprotein translocase subunit; Region: YajC; cl00806 983545008967 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 983545008968 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 983545008969 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 983545008970 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 983545008971 PspA/IM30 family; Region: PspA_IM30; pfam04012 983545008972 Ion channel; Region: Ion_trans_2; cl11596 983545008973 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 983545008974 Predicted membrane protein [Function unknown]; Region: COG3766 983545008975 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 983545008976 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 983545008977 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 983545008978 Rhomboid family; Region: Rhomboid; cl11446 983545008979 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 983545008980 Alkaline phosphatase homologues; Region: alkPPc; smart00098 983545008981 active site 983545008982 dimer interface [polypeptide binding]; other site 983545008983 isocitrate lyase; Provisional; Region: PRK06498 983545008984 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 983545008985 tetramer interface [polypeptide binding]; other site 983545008986 active site 983545008987 Mg2+/Mn2+ binding site [ion binding]; other site 983545008988 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 983545008989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545008990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545008991 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 983545008992 substrate binding pocket [chemical binding]; other site 983545008993 dimerization interface [polypeptide binding]; other site 983545008994 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 983545008995 active site 983545008996 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 983545008997 active site 983545008998 metal-binding site [ion binding] 983545008999 nucleotide-binding site [chemical binding]; other site 983545009000 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 983545009001 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545009002 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 983545009003 putative NAD(P) binding site [chemical binding]; other site 983545009004 active site 983545009005 putative substrate binding site [chemical binding]; other site 983545009006 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 983545009007 putative active site [active] 983545009008 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 983545009009 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 983545009010 active site 983545009011 nucleophile elbow; other site 983545009012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545009013 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545009014 FAD binding domain; Region: FAD_binding_4; pfam01565 983545009015 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545009016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545009017 binding surface 983545009018 TPR motif; other site 983545009019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545009020 TPR motif; other site 983545009021 binding surface 983545009022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545009023 binding surface 983545009024 TPR motif; other site 983545009025 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 983545009026 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545009027 active site 983545009028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009029 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545009030 putative ADP-binding pocket [chemical binding]; other site 983545009031 polysaccharide deactylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 983545009032 FemAB family; Region: FemAB; cl11444 983545009033 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545009034 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545009035 active site 983545009036 dimer interface [polypeptide binding]; other site 983545009037 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 983545009038 Ligand Binding Site [chemical binding]; other site 983545009039 Molecular Tunnel; other site 983545009040 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 983545009041 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 983545009042 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 983545009043 putative ADP-binding pocket [chemical binding]; other site 983545009044 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 983545009045 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545009046 active site 983545009047 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 983545009048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 983545009049 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 983545009050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545009052 serine O-acetyltransferase; Region: cysE; TIGR01172 983545009053 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 983545009054 trimer interface [polypeptide binding]; other site 983545009055 active site 983545009056 substrate binding site [chemical binding]; other site 983545009057 CoA binding site [chemical binding]; other site 983545009058 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 983545009059 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 983545009060 O-Antigen ligase; Region: Wzy_C; cl04850 983545009061 eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495 983545009062 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 983545009063 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 983545009064 polysaccharide deactylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 983545009065 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 983545009066 Domain of unknown function (DUF3473); Region: DUF3473; pfam11959 983545009067 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 983545009068 Bacterial sugar transferase; Region: Bac_transf; cl00939 983545009069 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545009070 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545009071 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 983545009072 Chain length determinant protein; Region: Wzz; cl01623 983545009073 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 983545009074 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545009075 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 983545009076 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 983545009077 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 983545009078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009079 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 983545009080 active site 983545009081 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 983545009082 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 983545009083 hypothetical protein; Provisional; Region: PRK11239 983545009084 Protein of unknown function, DUF480; Region: DUF480; cl01209 983545009085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545009086 Helix-turn-helix domain; Region: HTH_18; pfam12833 983545009087 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 983545009088 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 983545009089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545009090 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 983545009091 PAS fold; Region: PAS_4; pfam08448 983545009092 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545009093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545009094 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 983545009095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009096 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 983545009097 L-serine binding site [chemical binding]; other site 983545009098 ACT domain interface; other site 983545009099 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 983545009100 catalytic residues [active] 983545009101 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 983545009102 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 983545009103 glutathione synthetase; Provisional; Region: PRK05246 983545009104 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 983545009105 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545009106 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983545009107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545009108 active site 983545009109 phosphorylation site [posttranslational modification] 983545009110 intermolecular recognition site; other site 983545009111 dimerization interface [polypeptide binding]; other site 983545009112 LytTr DNA-binding domain; Region: LytTR; cl04498 983545009113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 983545009114 Histidine kinase; Region: His_kinase; pfam06580 983545009115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 983545009116 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 983545009117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545009118 active site 983545009119 phosphorylation site [posttranslational modification] 983545009120 intermolecular recognition site; other site 983545009121 dimerization interface [polypeptide binding]; other site 983545009122 LytTr DNA-binding domain; Region: LytTR; cl04498 983545009123 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545009124 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545009125 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 983545009126 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 983545009127 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545009128 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 983545009129 Domain of unknown function (DUF305); Region: DUF305; pfam03713 983545009130 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545009131 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 983545009132 putative metal dependent hydrolase; Provisional; Region: PRK11598 983545009133 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545009134 Sulfatase; Region: Sulfatase; cl10460 983545009135 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 983545009136 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 983545009137 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545009138 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 983545009139 Ligand binding site [chemical binding]; other site 983545009140 Putative Catalytic site [active] 983545009141 DXD motif; other site 983545009142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545009143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545009144 active site 983545009145 phosphorylation site [posttranslational modification] 983545009146 intermolecular recognition site; other site 983545009147 dimerization interface [polypeptide binding]; other site 983545009148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545009149 DNA binding site [nucleotide binding] 983545009150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545009151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545009152 dimer interface [polypeptide binding]; other site 983545009153 phosphorylation site [posttranslational modification] 983545009154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009155 ATP binding site [chemical binding]; other site 983545009156 Mg2+ binding site [ion binding]; other site 983545009157 G-X-G motif; other site 983545009158 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545009159 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545009160 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009161 N-terminal plug; other site 983545009162 ligand-binding site [chemical binding]; other site 983545009163 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 983545009164 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 983545009165 Walker A/P-loop; other site 983545009166 ATP binding site [chemical binding]; other site 983545009167 Q-loop/lid; other site 983545009168 ABC transporter signature motif; other site 983545009169 Walker B; other site 983545009170 D-loop; other site 983545009171 H-loop/switch region; other site 983545009172 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 983545009173 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 983545009174 ABC-ATPase subunit interface; other site 983545009175 dimer interface [polypeptide binding]; other site 983545009176 putative PBP binding regions; other site 983545009177 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 983545009178 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 983545009179 active site pocket [active] 983545009180 putative dimer interface [polypeptide binding]; other site 983545009181 putative cataytic base [active] 983545009182 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 983545009183 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 983545009184 homotrimer interface [polypeptide binding]; other site 983545009185 Walker A motif; other site 983545009186 GTP binding site [chemical binding]; other site 983545009187 Walker B motif; other site 983545009188 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545009189 catalytic core [active] 983545009190 cobyric acid synthase; Provisional; Region: PRK00784 983545009191 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545009192 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545009193 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 983545009194 catalytic triad [active] 983545009195 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 983545009196 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 983545009197 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 983545009198 homodimer interface [polypeptide binding]; other site 983545009199 Walker A motif; other site 983545009200 ATP binding site [chemical binding]; other site 983545009201 hydroxycobalamin binding site [chemical binding]; other site 983545009202 Walker B motif; other site 983545009203 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 983545009204 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 983545009205 cobalamin binding residues [chemical binding]; other site 983545009206 putative BtuC binding residues; other site 983545009207 dimer interface [polypeptide binding]; other site 983545009208 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 983545009209 catalytic core [active] 983545009210 CobD/Cbib protein; Region: CobD_Cbib; cl00561 983545009211 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 983545009212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545009213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545009214 homodimer interface [polypeptide binding]; other site 983545009215 catalytic residue [active] 983545009216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545009218 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 983545009219 putative effector binding pocket; other site 983545009220 dimerization interface [polypeptide binding]; other site 983545009221 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545009222 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 983545009223 putative C-terminal domain interface [polypeptide binding]; other site 983545009224 putative GSH binding site (G-site) [chemical binding]; other site 983545009225 putative dimer interface [polypeptide binding]; other site 983545009226 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 983545009227 dimer interface [polypeptide binding]; other site 983545009228 substrate binding pocket (H-site) [chemical binding]; other site 983545009229 N-terminal domain interface [polypeptide binding]; other site 983545009230 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545009231 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 983545009232 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 983545009233 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 983545009234 FAD binding pocket [chemical binding]; other site 983545009235 FAD binding motif [chemical binding]; other site 983545009236 phosphate binding motif [ion binding]; other site 983545009237 beta-alpha-beta structure motif; other site 983545009238 NAD binding pocket [chemical binding]; other site 983545009239 Heme binding pocket [chemical binding]; other site 983545009240 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545009241 catalytic loop [active] 983545009242 iron binding site [ion binding]; other site 983545009243 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 983545009244 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 983545009245 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 983545009246 dimerization interface [polypeptide binding]; other site 983545009247 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 983545009248 putative active cleft [active] 983545009249 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545009250 active site 983545009251 Sodium:solute symporter family; Region: SSF; cl00456 983545009252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545009253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545009254 DNA binding site [nucleotide binding] 983545009255 domain linker motif; other site 983545009256 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 983545009257 dimerization interface [polypeptide binding]; other site 983545009258 ligand binding site [chemical binding]; other site 983545009259 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 983545009260 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 983545009261 dimerization interface [polypeptide binding]; other site 983545009262 putative active cleft [active] 983545009263 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009264 Sulfatase; Region: Sulfatase; cl10460 983545009265 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 983545009266 nudix motif; other site 983545009267 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545009268 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545009269 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545009270 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 983545009271 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 983545009272 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 983545009273 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009274 N-terminal plug; other site 983545009275 ligand-binding site [chemical binding]; other site 983545009276 Carbon starvation protein CstA; Region: CstA; cl00856 983545009277 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 983545009278 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 983545009279 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 983545009280 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 983545009281 tetramer interface [polypeptide binding]; other site 983545009282 heme binding pocket [chemical binding]; other site 983545009283 Uncharacterized conserved protein [Function unknown]; Region: COG3379 983545009284 Sulfatase; Region: Sulfatase; cl10460 983545009285 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 983545009286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 983545009287 FeS/SAM binding site; other site 983545009288 HemN C-terminal region; Region: HemN_C; pfam06969 983545009289 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 983545009290 active site 983545009291 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 983545009292 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 983545009293 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 983545009294 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 983545009295 Acyltransferase family; Region: Acyl_transf_3; pfam01757 983545009296 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 983545009297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 983545009298 active site 983545009299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009300 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545009301 putative ADP-binding pocket [chemical binding]; other site 983545009302 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009303 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 983545009304 putative ADP-binding pocket [chemical binding]; other site 983545009305 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 983545009306 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545009307 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 983545009308 putative NAD(P) binding site [chemical binding]; other site 983545009309 active site 983545009310 putative substrate binding site [chemical binding]; other site 983545009311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545009312 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 983545009313 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 983545009314 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 983545009315 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 983545009316 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 983545009317 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 983545009318 Bacterial protein of unknown function (DUF920); Region: DUF920; cl01479 983545009319 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 983545009320 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009321 metal binding site [ion binding]; metal-binding site 983545009322 active site 983545009323 I-site; other site 983545009324 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545009325 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 983545009326 O-Antigen ligase; Region: Wzy_C; cl04850 983545009327 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 983545009328 PHP domain; Region: PHP; pfam02811 983545009329 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 983545009330 Chain length determinant protein; Region: Wzz; cl01623 983545009331 Chain length determinant protein; Region: Wzz; cl01623 983545009332 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545009333 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 983545009334 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 983545009335 SLBB domain; Region: SLBB; pfam10531 983545009336 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 983545009337 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 983545009338 Bacterial sugar transferase; Region: Bac_transf; cl00939 983545009339 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 983545009340 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 983545009341 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 983545009342 catalytic residue [active] 983545009343 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 983545009344 catalytic residues [active] 983545009345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545009346 peroxiredoxin; Region: AhpC; TIGR03137 983545009347 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 983545009348 dimer interface [polypeptide binding]; other site 983545009349 decamer (pentamer of dimers) interface [polypeptide binding]; other site 983545009350 catalytic triad [active] 983545009351 peroxidatic and resolving cysteines [active] 983545009352 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545009353 Gram-negative bacterial tonB protein; Region: TonB; cl10048 983545009354 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 983545009355 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545009356 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 983545009357 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 983545009358 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545009359 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009360 N-terminal plug; other site 983545009361 ligand-binding site [chemical binding]; other site 983545009362 Cytochrome c; Region: Cytochrom_C; cl11414 983545009363 Iron permease FTR1 family; Region: FTR1; cl00475 983545009364 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 983545009365 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545009366 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545009367 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545009368 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 983545009369 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 983545009370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545009371 dimer interface [polypeptide binding]; other site 983545009372 phosphorylation site [posttranslational modification] 983545009373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009374 ATP binding site [chemical binding]; other site 983545009375 Mg2+ binding site [ion binding]; other site 983545009376 G-X-G motif; other site 983545009377 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 983545009378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545009379 active site 983545009380 phosphorylation site [posttranslational modification] 983545009381 intermolecular recognition site; other site 983545009382 dimerization interface [polypeptide binding]; other site 983545009383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545009384 DNA binding site [nucleotide binding] 983545009385 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 983545009386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 983545009387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009388 ATP binding site [chemical binding]; other site 983545009389 Mg2+ binding site [ion binding]; other site 983545009390 G-X-G motif; other site 983545009391 Putative exonuclease, RdgC; Region: RdgC; cl01122 983545009392 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545009393 Nudix hydrolase homolog; Region: PLN02791 983545009394 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009395 metal binding site [ion binding]; metal-binding site 983545009396 active site 983545009397 I-site; other site 983545009398 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545009399 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 983545009400 nucleotide binding site/active site [active] 983545009401 HIT family signature motif; other site 983545009402 catalytic residue [active] 983545009403 Bacitracin resistance protein BacA; Region: BacA; cl00858 983545009404 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 983545009405 catalytic center binding site [active] 983545009406 ATP binding site [chemical binding]; other site 983545009407 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 983545009408 homooctamer interface [polypeptide binding]; other site 983545009409 active site 983545009410 Domain of unknown function (DUF205); Region: DUF205; cl00410 983545009411 UGMP family protein; Validated; Region: PRK09604 983545009412 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 983545009413 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 983545009414 GatB domain; Region: GatB_Yqey; cl11497 983545009415 DNA primase; Validated; Region: dnaG; PRK05667 983545009416 CHC2 zinc finger; Region: zf-CHC2; cl02597 983545009417 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 983545009418 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 983545009419 active site 983545009420 metal binding site [ion binding]; metal-binding site 983545009421 interdomain interaction site; other site 983545009422 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 983545009423 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 983545009424 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 983545009425 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 983545009426 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545009427 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 983545009428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545009429 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983545009430 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 983545009431 DNA binding residues [nucleotide binding] 983545009432 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545009433 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545009434 Endonuclease I; Region: Endonuclease_1; cl01003 983545009435 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 983545009436 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 983545009437 generic binding surface I; other site 983545009438 generic binding surface II; other site 983545009439 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545009440 putative catalytic site [active] 983545009441 putative metal binding site [ion binding]; other site 983545009442 putative phosphate binding site [ion binding]; other site 983545009443 Protein of unknown function (DUF1260); Region: DUF1260; cl01170 983545009444 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 983545009445 putative acyl-acceptor binding pocket; other site 983545009446 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 983545009447 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545009448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545009449 Zn2+ binding site [ion binding]; other site 983545009450 Mg2+ binding site [ion binding]; other site 983545009451 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 983545009452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545009453 active site 983545009454 phosphorylation site [posttranslational modification] 983545009455 intermolecular recognition site; other site 983545009456 dimerization interface [polypeptide binding]; other site 983545009457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545009458 Walker A motif; other site 983545009459 ATP binding site [chemical binding]; other site 983545009460 Walker B motif; other site 983545009461 arginine finger; other site 983545009462 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 983545009463 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 983545009464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 983545009465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545009466 dimer interface [polypeptide binding]; other site 983545009467 phosphorylation site [posttranslational modification] 983545009468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009469 ATP binding site [chemical binding]; other site 983545009470 Mg2+ binding site [ion binding]; other site 983545009471 G-X-G motif; other site 983545009472 glutamine synthetase; Provisional; Region: glnA; PRK09469 983545009473 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 983545009474 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 983545009475 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 983545009476 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 983545009477 G1 box; other site 983545009478 putative GEF interaction site [polypeptide binding]; other site 983545009479 GTP/Mg2+ binding site [chemical binding]; other site 983545009480 Switch I region; other site 983545009481 G2 box; other site 983545009482 G3 box; other site 983545009483 Switch II region; other site 983545009484 G4 box; other site 983545009485 G5 box; other site 983545009486 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 983545009487 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 983545009488 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 983545009489 active site 983545009490 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 983545009491 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 983545009492 active sites [active] 983545009493 tetramer interface [polypeptide binding]; other site 983545009494 urocanate hydratase; Provisional; Region: PRK05414 983545009495 urocanate hydratase; Region: hutU; TIGR01228 983545009496 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 983545009497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545009498 DNA-binding site [nucleotide binding]; DNA binding site 983545009499 UTRA domain; Region: UTRA; cl06649 983545009500 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983545009501 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 983545009502 active site 983545009503 Arginase family; Region: Arginase; cl00306 983545009504 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 983545009505 dimer interface [polypeptide binding]; other site 983545009506 FMN binding site [chemical binding]; other site 983545009507 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 983545009508 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 983545009509 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 983545009510 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 983545009511 alphaNTD homodimer interface [polypeptide binding]; other site 983545009512 alphaNTD - beta interaction site [polypeptide binding]; other site 983545009513 alphaNTD - beta' interaction site [polypeptide binding]; other site 983545009514 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 983545009515 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 983545009516 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 983545009517 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 983545009518 RNA binding surface [nucleotide binding]; other site 983545009519 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 983545009520 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 983545009521 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 983545009522 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 983545009523 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 983545009524 SecY translocase; Region: SecY; pfam00344 983545009525 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 983545009526 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 983545009527 23S rRNA binding site [nucleotide binding]; other site 983545009528 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 983545009529 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 983545009530 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 983545009531 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 983545009532 5S rRNA interface [nucleotide binding]; other site 983545009533 23S rRNA interface [nucleotide binding]; other site 983545009534 L5 interface [polypeptide binding]; other site 983545009535 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 983545009536 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 983545009537 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 983545009538 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 983545009539 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 983545009540 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 983545009541 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 983545009542 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 983545009543 KOW motif; Region: KOW; cl00354 983545009544 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 983545009545 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 983545009546 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545009547 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 983545009548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545009549 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 983545009550 dimerization interface [polypeptide binding]; other site 983545009551 substrate binding pocket [chemical binding]; other site 983545009552 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 983545009553 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 983545009554 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545009555 ribonuclease R; Region: RNase_R; TIGR02063 983545009556 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 983545009557 RNB domain; Region: RNB; pfam00773 983545009558 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 983545009559 RNA binding site [nucleotide binding]; other site 983545009560 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 983545009561 Sel1 repeat; Region: Sel1; cl02723 983545009562 Phosphate-starvation-inducible E; Region: PsiE; cl01264 983545009563 FMN reductase; Validated; Region: fre; PRK08051 983545009564 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189 983545009565 FAD binding pocket [chemical binding]; other site 983545009566 FAD binding motif [chemical binding]; other site 983545009567 phosphate binding motif [ion binding]; other site 983545009568 beta-alpha-beta structure motif; other site 983545009569 NAD binding pocket [chemical binding]; other site 983545009570 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 983545009571 lysophospholipase L2; Provisional; Region: PRK10749 983545009572 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545009573 two-component sensor protein; Provisional; Region: cpxA; PRK09470 983545009574 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 983545009575 dimerization interface [polypeptide binding]; other site 983545009576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545009577 dimer interface [polypeptide binding]; other site 983545009578 phosphorylation site [posttranslational modification] 983545009579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009580 ATP binding site [chemical binding]; other site 983545009581 Mg2+ binding site [ion binding]; other site 983545009582 G-X-G motif; other site 983545009583 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 983545009584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545009585 active site 983545009586 phosphorylation site [posttranslational modification] 983545009587 intermolecular recognition site; other site 983545009588 dimerization interface [polypeptide binding]; other site 983545009589 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545009590 DNA binding site [nucleotide binding] 983545009591 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 983545009592 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 983545009593 active site 983545009594 dimer interfaces [polypeptide binding]; other site 983545009595 catalytic residues [active] 983545009596 kelch-like protein; Provisional; Region: PHA03098 983545009597 acetylornithine deacetylase; Provisional; Region: PRK05111 983545009598 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 983545009599 metal binding site [ion binding]; metal-binding site 983545009600 putative dimer interface [polypeptide binding]; other site 983545009601 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 983545009602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009603 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 983545009604 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 983545009605 nucleotide binding site [chemical binding]; other site 983545009606 N-acetyl-L-glutamate binding site [chemical binding]; other site 983545009607 ornithine carbamoyltransferase; Provisional; Region: PRK14805 983545009608 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 983545009609 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 983545009610 argininosuccinate synthase; Provisional; Region: PLN00200 983545009611 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 983545009612 ANP binding site [chemical binding]; other site 983545009613 Substrate Binding Site II [chemical binding]; other site 983545009614 Substrate Binding Site I [chemical binding]; other site 983545009615 argininosuccinate lyase; Provisional; Region: PRK04833 983545009616 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 983545009617 active sites [active] 983545009618 tetramer interface [polypeptide binding]; other site 983545009619 N-acetylglutamate synthase; Validated; Region: PRK05279 983545009620 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237 983545009621 putative feedback inhibition sensing region; other site 983545009622 putative nucleotide binding site [chemical binding]; other site 983545009623 putative substrate binding site [chemical binding]; other site 983545009624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545009625 HopJ type III effector protein; Region: HopJ; pfam08888 983545009626 Flagellin N-methylase; Region: FliB; cl00497 983545009627 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 983545009628 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545009629 active site 983545009630 intersubunit interface [polypeptide binding]; other site 983545009631 catalytic residue [active] 983545009632 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 983545009633 Dehydratase family; Region: ILVD_EDD; cl00340 983545009634 6-phosphogluconate dehydratase; Region: edd; TIGR01196 983545009635 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 983545009636 putative active site [active] 983545009637 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 983545009638 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 983545009639 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 983545009640 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 983545009641 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 983545009642 putative active site [active] 983545009643 pyruvate kinase; Provisional; Region: PRK05826 983545009644 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545009645 domain interfaces; other site 983545009646 active site 983545009647 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545009648 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545009649 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009650 N-terminal plug; other site 983545009651 ligand-binding site [chemical binding]; other site 983545009652 Uncharacterized conserved protein [Function unknown]; Region: COG3268 983545009653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009654 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 983545009655 Ca2+ binding site [ion binding]; other site 983545009656 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 983545009657 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 983545009658 active site residue [active] 983545009659 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545009660 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 983545009661 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545009662 Protein kinase; unclassified specificity; Region: STYKc; smart00221 983545009663 active site 983545009664 ATP binding site [chemical binding]; other site 983545009665 substrate binding site [chemical binding]; other site 983545009666 activation loop (A-loop); other site 983545009667 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545009668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545009669 binding surface 983545009670 TPR motif; other site 983545009671 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545009672 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545009673 MASE1; Region: MASE1; pfam05231 983545009674 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 983545009675 putative active site [active] 983545009676 putative dimer interface [polypeptide binding]; other site 983545009677 NIPSNAP; Region: NIPSNAP; pfam07978 983545009678 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 983545009679 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545009680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009681 NAD(P) binding site [chemical binding]; other site 983545009682 active site 983545009683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009684 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 983545009685 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 983545009686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545009687 substrate binding site [chemical binding]; other site 983545009688 oxyanion hole (OAH) forming residues; other site 983545009689 trimer interface [polypeptide binding]; other site 983545009690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545009691 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 983545009692 substrate binding pocket [chemical binding]; other site 983545009693 FAD binding site [chemical binding]; other site 983545009694 catalytic base [active] 983545009695 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 983545009696 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545009697 tetrameric interface [polypeptide binding]; other site 983545009698 NAD binding site [chemical binding]; other site 983545009699 catalytic residues [active] 983545009700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545009701 active site 983545009702 phosphorylation site [posttranslational modification] 983545009703 intermolecular recognition site; other site 983545009704 dimerization interface [polypeptide binding]; other site 983545009705 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 983545009706 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 983545009707 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 983545009708 active site 983545009709 dimer interface [polypeptide binding]; other site 983545009710 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545009711 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009712 N-terminal plug; other site 983545009713 ligand-binding site [chemical binding]; other site 983545009714 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545009715 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009716 N-terminal plug; other site 983545009717 ligand-binding site [chemical binding]; other site 983545009718 Septum formation topological specificity factor MinE; Region: MinE; cl00538 983545009719 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 983545009720 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 983545009721 Switch I; other site 983545009722 Switch II; other site 983545009723 septum formation inhibitor; Reviewed; Region: minC; PRK00339 983545009724 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 983545009725 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 983545009726 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 983545009727 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 983545009728 FMN binding site [chemical binding]; other site 983545009729 substrate binding site [chemical binding]; other site 983545009730 putative catalytic residue [active] 983545009731 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 983545009732 maleylacetoacetate isomerase; Region: maiA; TIGR01262 983545009733 C-terminal domain interface [polypeptide binding]; other site 983545009734 GSH binding site (G-site) [chemical binding]; other site 983545009735 putative dimer interface [polypeptide binding]; other site 983545009736 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 983545009737 dimer interface [polypeptide binding]; other site 983545009738 N-terminal domain interface [polypeptide binding]; other site 983545009739 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 983545009740 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 983545009741 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 983545009742 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 983545009743 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 983545009744 Sodium:solute symporter family; Region: SSF; cl00456 983545009745 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545009746 Protein of unknown function, DUF485; Region: DUF485; cl01231 983545009747 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009748 Sulfatase; Region: Sulfatase; cl10460 983545009749 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009750 Sulfatase; Region: Sulfatase; cl10460 983545009751 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545009752 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009753 N-terminal plug; other site 983545009754 ligand-binding site [chemical binding]; other site 983545009755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545009756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545009757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 983545009758 dimerization interface [polypeptide binding]; other site 983545009759 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 983545009760 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Provisional; Region: PRK08575 983545009761 substrate binding site [chemical binding]; other site 983545009762 THF binding site; other site 983545009763 zinc-binding site [ion binding]; other site 983545009764 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 983545009765 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 983545009766 Domain of unknown function DUF20; Region: UPF0118; cl00465 983545009767 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 983545009768 active site 983545009769 intersubunit interface [polypeptide binding]; other site 983545009770 catalytic residue [active] 983545009771 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 983545009772 active site 983545009773 catalytic residues [active] 983545009774 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545009775 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545009776 substrate binding site [chemical binding]; other site 983545009777 ATP binding site [chemical binding]; other site 983545009778 putative transporter; Provisional; Region: PRK10484 983545009779 Sodium:solute symporter family; Region: SSF; cl00456 983545009780 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 983545009781 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 983545009782 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 983545009783 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545009784 domain; Region: Glyco_hydro_2; pfam00703 983545009785 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 983545009786 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 983545009787 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009788 Sulfatase; Region: Sulfatase; cl10460 983545009789 Sulfatase; Region: Sulfatase; cl10460 983545009790 Cupin domain; Region: Cupin_2; cl09118 983545009791 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 983545009792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545009793 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009794 Sulfatase; Region: Sulfatase; cl10460 983545009795 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545009796 Probable beta-xylosidase; Provisional; Region: PLN03080 983545009797 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545009798 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545009799 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545009800 calcium binding site [ion binding]; other site 983545009801 active site 983545009802 catalytic residues [active] 983545009803 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 983545009804 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 983545009805 Domain of unknown function (DUF718); Region: DUF718; cl01281 983545009806 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 983545009807 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545009808 domain; Region: Glyco_hydro_2; pfam00703 983545009809 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 983545009810 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 983545009811 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009812 Sulfatase; Region: Sulfatase; cl10460 983545009813 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009814 Sulfatase; Region: Sulfatase; cl10460 983545009815 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009816 Sulfatase; Region: Sulfatase; cl10460 983545009817 Cupin domain; Region: Cupin_2; cl09118 983545009818 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545009819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545009820 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 983545009821 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 983545009822 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 983545009823 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 983545009824 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 983545009825 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 983545009826 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 983545009827 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 983545009828 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545009829 N-terminal plug; other site 983545009830 ligand-binding site [chemical binding]; other site 983545009831 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 983545009832 active site 983545009833 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 983545009834 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 983545009835 substrate binding site [chemical binding]; other site 983545009836 active site 983545009837 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 983545009838 metal binding site [ion binding]; metal-binding site 983545009839 ligand binding site [chemical binding]; other site 983545009840 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545009841 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545009842 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545009843 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 983545009844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545009845 DNA polymerase I; Provisional; Region: PRK05755 983545009846 Beta-agarase, member of glycosyl hydrolase family 16; Region: GH16_beta_agarase; cd02178 983545009847 calcium binding site [ion binding]; other site 983545009848 active site 983545009849 catalytic residues [active] 983545009850 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 983545009851 domain; Region: Glyco_hydro_2; pfam00703 983545009852 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 983545009853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545009854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545009855 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545009856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 983545009857 galactarate dehydratase; Region: galactar-dH20; TIGR03248 983545009858 SAF domain; Region: SAF; cl00555 983545009859 SAF domain; Region: SAF; cl00555 983545009860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 983545009861 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545009862 active site 983545009863 catalytic tetrad [active] 983545009864 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 983545009865 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545009866 active site 983545009867 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 983545009868 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 983545009869 putative NAD(P) binding site [chemical binding]; other site 983545009870 catalytic Zn binding site [ion binding]; other site 983545009871 structural Zn binding site [ion binding]; other site 983545009872 Transcriptional regulator [Transcription]; Region: IclR; COG1414 983545009873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545009874 Sulfatase; Region: Sulfatase; cl10460 983545009875 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 983545009876 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 983545009877 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 983545009878 RDD family; Region: RDD; cl00746 983545009879 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 983545009880 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983545009881 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 983545009882 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 983545009883 multifunctional aminopeptidase A; Provisional; Region: PRK00913 983545009884 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 983545009885 interface (dimer of trimers) [polypeptide binding]; other site 983545009886 Substrate-binding/catalytic site; other site 983545009887 Zn-binding sites [ion binding]; other site 983545009888 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 983545009889 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 983545009890 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 983545009891 HIGH motif; other site 983545009892 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 983545009893 active site 983545009894 KMSKS motif; other site 983545009895 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 983545009896 tRNA binding surface [nucleotide binding]; other site 983545009897 anticodon binding site; other site 983545009898 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 983545009899 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 983545009900 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 983545009901 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 983545009902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009903 metal binding site [ion binding]; metal-binding site 983545009904 active site 983545009905 I-site; other site 983545009906 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 983545009907 MltA-interacting protein MipA; Region: MipA; cl01504 983545009908 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 983545009909 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 983545009910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545009911 active site 983545009912 phosphorylation site [posttranslational modification] 983545009913 intermolecular recognition site; other site 983545009914 dimerization interface [polypeptide binding]; other site 983545009915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545009916 DNA binding site [nucleotide binding] 983545009917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545009918 dimer interface [polypeptide binding]; other site 983545009919 phosphorylation site [posttranslational modification] 983545009920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545009921 ATP binding site [chemical binding]; other site 983545009922 Mg2+ binding site [ion binding]; other site 983545009923 G-X-G motif; other site 983545009924 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 983545009925 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 983545009926 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 983545009927 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545009928 Phosphotransferase enzyme family; Region: APH; pfam01636 983545009929 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 983545009930 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 983545009931 catalytic residues [active] 983545009932 hinge region; other site 983545009933 alpha helical domain; other site 983545009934 MASE1; Region: MASE1; pfam05231 983545009935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545009936 metal binding site [ion binding]; metal-binding site 983545009937 active site 983545009938 I-site; other site 983545009939 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 983545009940 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 983545009941 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 983545009942 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545009943 catalytic residue [active] 983545009944 homoserine kinase; Provisional; Region: PRK01212 983545009945 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 983545009946 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 983545009947 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli AKI-...; Region: AAK_AK-HSDH; cd04257 983545009948 putative catalytic residues [active] 983545009949 putative nucleotide binding site [chemical binding]; other site 983545009950 putative aspartate binding site [chemical binding]; other site 983545009951 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 983545009952 dimer interface [polypeptide binding]; other site 983545009953 putative threonine allosteric regulatory site; other site 983545009954 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 983545009955 putative threonine allosteric regulatory site; other site 983545009956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545009957 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 983545009958 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 983545009959 hydrolase, ortholog 1, exosortase system type 1 associated; Region: hydr1_PEP; TIGR03100 983545009960 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 983545009961 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 983545009962 putative NAD(P) binding site [chemical binding]; other site 983545009963 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545009964 Ycf48-like protein; Provisional; Region: PRK13684 983545009965 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 983545009966 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545009967 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 983545009968 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 983545009969 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545009970 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 983545009971 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 983545009972 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545009973 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 983545009974 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; cl01902 983545009975 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 983545009976 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545009977 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 983545009978 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 983545009979 Prostaglandin dehydrogenases; Region: PGDH; cd05288 983545009980 NAD(P) binding site [chemical binding]; other site 983545009981 substrate binding site [chemical binding]; other site 983545009982 dimer interface [polypeptide binding]; other site 983545009983 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 983545009984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 983545009985 DNA binding residues [nucleotide binding] 983545009986 dimerization interface [polypeptide binding]; other site 983545009987 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 983545009988 glycine dehydrogenase; Provisional; Region: PRK05367 983545009989 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 983545009990 tetramer interface [polypeptide binding]; other site 983545009991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545009992 catalytic residue [active] 983545009993 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 983545009994 tetramer interface [polypeptide binding]; other site 983545009995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545009996 catalytic residue [active] 983545009997 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 983545009998 lipoyl attachment site [posttranslational modification]; other site 983545009999 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 983545010000 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 983545010001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545010002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545010003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545010004 dimerization interface [polypeptide binding]; other site 983545010005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545010006 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 983545010007 Haemolysin-III related; Region: HlyIII; cl03831 983545010008 Predicted transcriptional regulator [Transcription]; Region: COG2378 983545010009 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 983545010010 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 983545010011 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545010012 metal binding triad; other site 983545010013 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545010014 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 983545010015 metal binding triad; other site 983545010016 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 983545010017 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 983545010018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 983545010019 putative acyl-acceptor binding pocket; other site 983545010020 putative diguanylate cyclase; Provisional; Region: PRK09776 983545010021 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 983545010022 bacterio-opsin activator; Provisional; Region: PRK13558 983545010023 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 983545010024 PAS domain S-box; Region: sensory_box; TIGR00229 983545010025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545010026 putative active site [active] 983545010027 heme pocket [chemical binding]; other site 983545010028 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 983545010029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545010030 dimer interface [polypeptide binding]; other site 983545010031 phosphorylation site [posttranslational modification] 983545010032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010033 ATP binding site [chemical binding]; other site 983545010034 Mg2+ binding site [ion binding]; other site 983545010035 G-X-G motif; other site 983545010036 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010038 active site 983545010039 phosphorylation site [posttranslational modification] 983545010040 intermolecular recognition site; other site 983545010041 dimerization interface [polypeptide binding]; other site 983545010042 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010044 active site 983545010045 phosphorylation site [posttranslational modification] 983545010046 intermolecular recognition site; other site 983545010047 dimerization interface [polypeptide binding]; other site 983545010048 Protein of unknown function (DUF3081); Region: DUF3081; pfam11280 983545010049 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 983545010050 Beta-lactamase; Region: Beta-lactamase; cl01009 983545010051 ChaB; Region: ChaB; cl01887 983545010052 Protein of unknown function (DUF808); Region: DUF808; cl01002 983545010053 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721 983545010054 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 983545010055 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545010056 Sulfatase; Region: Sulfatase; cl10460 983545010057 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 983545010058 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545010059 active site residue [active] 983545010060 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 983545010061 GSH binding site [chemical binding]; other site 983545010062 catalytic residues [active] 983545010063 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 983545010064 SecA binding site; other site 983545010065 Preprotein binding site; other site 983545010066 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 983545010067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010068 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 983545010069 hypothetical protein; Provisional; Region: PRK11383 983545010070 yiaA/B two helix domain; Region: YiaAB; cl01759 983545010071 yiaA/B two helix domain; Region: YiaAB; cl01759 983545010072 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 983545010073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545010074 Protein of unknown function (DUF328); Region: DUF328; cl01143 983545010075 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 983545010076 transaldolase-like protein; Provisional; Region: PTZ00411 983545010077 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 983545010078 active site 983545010079 dimer interface [polypeptide binding]; other site 983545010080 catalytic residue [active] 983545010081 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 983545010082 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 983545010083 active site 983545010084 dimer interface [polypeptide binding]; other site 983545010085 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 983545010086 dimer interface [polypeptide binding]; other site 983545010087 active site 983545010088 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 983545010089 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 983545010090 transcriptional regulator SlyA; Provisional; Region: PRK03573 983545010091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545010092 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 983545010093 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010094 N-terminal plug; other site 983545010095 ligand-binding site [chemical binding]; other site 983545010096 aspartate aminotransferase; Provisional; Region: PRK08361 983545010097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 983545010098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545010099 homodimer interface [polypeptide binding]; other site 983545010100 catalytic residue [active] 983545010101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010102 active site 983545010103 phosphorylation site [posttranslational modification] 983545010104 intermolecular recognition site; other site 983545010105 dimerization interface [polypeptide binding]; other site 983545010106 DNA polymerase II; Reviewed; Region: PRK05762 983545010107 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 983545010108 active site 983545010109 catalytic site [active] 983545010110 substrate binding site [chemical binding]; other site 983545010111 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 983545010112 active site 983545010113 metal-binding site 983545010114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010115 metal binding site [ion binding]; metal-binding site 983545010116 active site 983545010117 I-site; other site 983545010118 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545010119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010120 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 983545010121 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 983545010122 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 983545010123 GTP/Mg2+ binding site [chemical binding]; other site 983545010124 G4 box; other site 983545010125 G5 box; other site 983545010126 G1 box; other site 983545010127 Switch I region; other site 983545010128 G2 box; other site 983545010129 G3 box; other site 983545010130 Switch II region; other site 983545010131 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545010132 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010133 N-terminal plug; other site 983545010134 ligand-binding site [chemical binding]; other site 983545010135 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010136 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010137 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010138 ligand-binding site [chemical binding]; other site 983545010139 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545010140 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545010141 classical (c) SDRs; Region: SDR_c; cd05233 983545010142 NAD(P) binding site [chemical binding]; other site 983545010143 active site 983545010144 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 983545010145 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 983545010146 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 983545010147 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 983545010148 ATP-binding site [chemical binding]; other site 983545010149 Gluconate-6-phosphate binding site [chemical binding]; other site 983545010150 Alginate lyase; Region: Alginate_lyase2; pfam08787 983545010151 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 983545010152 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 983545010153 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 983545010154 mannonate dehydratase; Provisional; Region: PRK03906 983545010155 mannonate dehydratase; Region: uxuA; TIGR00695 983545010156 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010157 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010158 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010159 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 983545010160 Heparinase II/III-like protein; Region: Hepar_II_III; cl02215 983545010161 Cation efflux family; Region: Cation_efflux; cl00316 983545010162 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 983545010163 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 983545010164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010165 metal binding site [ion binding]; metal-binding site 983545010166 active site 983545010167 I-site; other site 983545010168 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 983545010169 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 983545010170 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 983545010171 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 983545010172 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 983545010173 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 983545010174 substrate binding site [chemical binding]; other site 983545010175 ATP binding site [chemical binding]; other site 983545010176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010177 D-galactonate transporter; Region: 2A0114; TIGR00893 983545010178 putative substrate translocation pore; other site 983545010179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010180 Transcriptional regulators [Transcription]; Region: FadR; COG2186 983545010181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 983545010182 DNA-binding site [nucleotide binding]; DNA binding site 983545010183 FCD domain; Region: FCD; cl11656 983545010184 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 983545010185 classical (c) SDRs; Region: SDR_c; cd05233 983545010186 NAD(P) binding site [chemical binding]; other site 983545010187 active site 983545010188 FAD binding domain; Region: FAD_binding_3; pfam01494 983545010189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545010190 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 983545010191 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 983545010192 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 983545010193 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545010194 Protein of unknown function (DUF785); Region: DUF785; cl01682 983545010195 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 983545010196 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010198 active site 983545010199 phosphorylation site [posttranslational modification] 983545010200 intermolecular recognition site; other site 983545010201 dimerization interface [polypeptide binding]; other site 983545010202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010203 metal binding site [ion binding]; metal-binding site 983545010204 active site 983545010205 I-site; other site 983545010206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545010207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545010208 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545010209 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 983545010210 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 983545010211 dimer interface [polypeptide binding]; other site 983545010212 active site 983545010213 metal binding site [ion binding]; metal-binding site 983545010214 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 983545010215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010216 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545010217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010218 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 983545010219 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545010220 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010222 active site 983545010223 phosphorylation site [posttranslational modification] 983545010224 intermolecular recognition site; other site 983545010225 dimerization interface [polypeptide binding]; other site 983545010226 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 983545010227 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545010228 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545010229 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 983545010230 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 983545010231 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 983545010232 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 983545010233 putative S-transferase; Provisional; Region: PRK11752 983545010234 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 983545010235 C-terminal domain interface [polypeptide binding]; other site 983545010236 GSH binding site (G-site) [chemical binding]; other site 983545010237 dimer interface [polypeptide binding]; other site 983545010238 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 983545010239 dimer interface [polypeptide binding]; other site 983545010240 N-terminal domain interface [polypeptide binding]; other site 983545010241 putative substrate binding pocket (H-site) [chemical binding]; other site 983545010242 SapC; Region: SapC; pfam07277 983545010243 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 983545010244 Sodium:solute symporter family; Region: SSF; cl00456 983545010245 putative transporter; Provisional; Region: PRK10484 983545010246 SapC; Region: SapC; pfam07277 983545010247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545010248 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 983545010249 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010250 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010251 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010252 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 983545010253 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 983545010254 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 983545010255 active site 983545010256 dimer interface [polypeptide binding]; other site 983545010257 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 983545010258 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 983545010259 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 983545010260 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 983545010261 active site 983545010262 catalytic site [active] 983545010263 substrate binding site [chemical binding]; other site 983545010264 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 983545010265 Predicted methyltransferases [General function prediction only]; Region: COG0313 983545010266 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 983545010267 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 983545010268 putative ligand binding site [chemical binding]; other site 983545010269 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 983545010270 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 983545010271 dimer interface [polypeptide binding]; other site 983545010272 active site 983545010273 BON domain; Region: BON; cl02771 983545010274 BON domain; Region: BON; cl02771 983545010275 Stringent starvation protein B; Region: SspB; cl01120 983545010276 stringent starvation protein A; Provisional; Region: sspA; PRK09481 983545010277 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 983545010278 C-terminal domain interface [polypeptide binding]; other site 983545010279 putative GSH binding site (G-site) [chemical binding]; other site 983545010280 dimer interface [polypeptide binding]; other site 983545010281 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186 983545010282 dimer interface [polypeptide binding]; other site 983545010283 N-terminal domain interface [polypeptide binding]; other site 983545010284 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 983545010285 cytochrome b; Provisional; Region: CYTB; MTH00145 983545010286 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 983545010287 Qi binding site; other site 983545010288 intrachain domain interface; other site 983545010289 interchain domain interface [polypeptide binding]; other site 983545010290 heme bH binding site [chemical binding]; other site 983545010291 heme bL binding site [chemical binding]; other site 983545010292 Qo binding site; other site 983545010293 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cd00290 983545010294 interchain domain interface [polypeptide binding]; other site 983545010295 intrachain domain interface; other site 983545010296 Qi binding site; other site 983545010297 Qo binding site; other site 983545010298 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 983545010299 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 983545010300 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 983545010301 [2Fe-2S] cluster binding site [ion binding]; other site 983545010302 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 983545010303 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 983545010304 23S rRNA interface [nucleotide binding]; other site 983545010305 L3 interface [polypeptide binding]; other site 983545010306 FOG: CBS domain [General function prediction only]; Region: COG0517 983545010307 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_27; cd04640 983545010308 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 983545010309 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 983545010310 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 983545010311 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 983545010312 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 983545010313 synthetase active site [active] 983545010314 NTP binding site [chemical binding]; other site 983545010315 metal binding site [ion binding]; metal-binding site 983545010316 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 983545010317 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 983545010318 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 983545010319 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 983545010320 active site 983545010321 hydrophilic channel; other site 983545010322 dimerization interface [polypeptide binding]; other site 983545010323 catalytic residues [active] 983545010324 active site lid [active] 983545010325 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 983545010326 Recombination protein O N terminal; Region: RecO_N; pfam11967 983545010327 Recombination protein O C terminal; Region: RecO_C; pfam02565 983545010328 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 983545010329 DHH family; Region: DHH; pfam01368 983545010330 DHHA1 domain; Region: DHHA1; pfam02272 983545010331 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 983545010332 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 983545010333 dimerization domain [polypeptide binding]; other site 983545010334 dimer interface [polypeptide binding]; other site 983545010335 catalytic residues [active] 983545010336 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 983545010337 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 983545010338 Int/Topo IB signature motif; other site 983545010339 active site 983545010340 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 983545010341 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545010342 Walker A motif; other site 983545010343 ATP binding site [chemical binding]; other site 983545010344 Walker B motif; other site 983545010345 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 983545010346 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 983545010347 Walker A motif; other site 983545010348 ATP binding site [chemical binding]; other site 983545010349 Walker B motif; other site 983545010350 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 983545010351 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545010352 catalytic residue [active] 983545010353 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 983545010354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010355 YGGT family; Region: YGGT; cl00508 983545010356 YGGT family; Region: YGGT; cl00508 983545010357 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 983545010358 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545010359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545010360 dimer interface [polypeptide binding]; other site 983545010361 phosphorylation site [posttranslational modification] 983545010362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010363 ATP binding site [chemical binding]; other site 983545010364 Mg2+ binding site [ion binding]; other site 983545010365 G-X-G motif; other site 983545010366 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010368 active site 983545010369 phosphorylation site [posttranslational modification] 983545010370 intermolecular recognition site; other site 983545010371 dimerization interface [polypeptide binding]; other site 983545010372 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 983545010373 putative dimerization interface [polypeptide binding]; other site 983545010374 putative ligand binding site [chemical binding]; other site 983545010375 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545010376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545010377 xylulokinase; Provisional; Region: PRK15027 983545010378 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 983545010379 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 983545010380 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 983545010381 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 983545010382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010383 putative substrate translocation pore; other site 983545010384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010385 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 983545010386 substrate binding site [chemical binding]; other site 983545010387 active site 983545010388 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 983545010389 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 983545010390 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 983545010391 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545010392 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545010393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545010394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545010395 DNA binding site [nucleotide binding] 983545010396 domain linker motif; other site 983545010397 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 983545010398 dimerization interface (closed form) [polypeptide binding]; other site 983545010399 ligand binding site [chemical binding]; other site 983545010400 putative transporter; Provisional; Region: PRK11462 983545010401 putative symporter YagG; Provisional; Region: PRK09669 983545010402 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 983545010403 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545010404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010405 putative substrate translocation pore; other site 983545010406 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 983545010407 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545010408 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 983545010409 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545010410 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010411 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010412 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010413 SapC; Region: SapC; pfam07277 983545010414 Uncharacterized conserved protein [Function unknown]; Region: COG2850 983545010415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545010416 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545010417 putative catalytic site [active] 983545010418 putative metal binding site [ion binding]; other site 983545010419 putative phosphate binding site [ion binding]; other site 983545010420 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 983545010421 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 983545010422 putative active site [active] 983545010423 putative active site [active] 983545010424 catalytic site [active] 983545010425 catalytic site [active] 983545010426 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 983545010427 phospholipase D; Region: PLN02866 983545010428 putative active site [active] 983545010429 catalytic site [active] 983545010430 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545010431 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 983545010432 DNA-binding site [nucleotide binding]; DNA binding site 983545010433 RNA-binding motif; other site 983545010434 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 983545010435 dimer interface [polypeptide binding]; other site 983545010436 catalytic triad [active] 983545010437 peroxidatic and resolving cysteines [active] 983545010438 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 983545010439 NADP+ binding site [chemical binding]; other site 983545010440 folate binding site [chemical binding]; other site 983545010441 GTPase CgtA; Reviewed; Region: obgE; PRK12298 983545010442 GTP1/OBG; Region: GTP1_OBG; pfam01018 983545010443 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 983545010444 G1 box; other site 983545010445 GTP/Mg2+ binding site [chemical binding]; other site 983545010446 Switch I region; other site 983545010447 G2 box; other site 983545010448 G3 box; other site 983545010449 Switch II region; other site 983545010450 G4 box; other site 983545010451 G5 box; other site 983545010452 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 983545010453 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 983545010454 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 983545010455 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 983545010456 substrate binding pocket [chemical binding]; other site 983545010457 chain length determination region; other site 983545010458 substrate-Mg2+ binding site; other site 983545010459 catalytic residues [active] 983545010460 aspartate-rich region 1; other site 983545010461 active site lid residues [active] 983545010462 aspartate-rich region 2; other site 983545010463 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010464 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010465 Uncharacterized conserved protein [Function unknown]; Region: COG3595 983545010466 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 983545010467 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545010468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 983545010469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 983545010470 MOSC domain; Region: MOSC; pfam03473 983545010471 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 983545010472 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 983545010473 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 983545010474 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 983545010475 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 983545010476 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 983545010477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545010478 putative active site [active] 983545010479 heme pocket [chemical binding]; other site 983545010480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545010481 dimer interface [polypeptide binding]; other site 983545010482 phosphorylation site [posttranslational modification] 983545010483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010484 ATP binding site [chemical binding]; other site 983545010485 Mg2+ binding site [ion binding]; other site 983545010486 G-X-G motif; other site 983545010487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010488 active site 983545010489 phosphorylation site [posttranslational modification] 983545010490 intermolecular recognition site; other site 983545010491 dimerization interface [polypeptide binding]; other site 983545010492 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545010493 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 983545010494 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 983545010495 active site 983545010496 dimer interface [polypeptide binding]; other site 983545010497 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 983545010498 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 983545010499 active site 983545010500 FMN binding site [chemical binding]; other site 983545010501 substrate binding site [chemical binding]; other site 983545010502 3Fe-4S cluster binding site [ion binding]; other site 983545010503 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 983545010504 domain interface; other site 983545010505 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 983545010506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545010507 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 983545010508 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 983545010509 putative active site [active] 983545010510 metal binding site [ion binding]; metal-binding site 983545010511 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 983545010512 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 983545010513 catalytic residues [active] 983545010514 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 983545010515 oligomerisation interface [polypeptide binding]; other site 983545010516 mobile loop; other site 983545010517 roof hairpin; other site 983545010518 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 983545010519 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 983545010520 ring oligomerisation interface [polypeptide binding]; other site 983545010521 ATP/Mg binding site [chemical binding]; other site 983545010522 stacking interactions; other site 983545010523 hinge regions; other site 983545010524 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 983545010525 multiple promoter invertase; Provisional; Region: mpi; PRK13413 983545010526 catalytic residues [active] 983545010527 catalytic nucleophile [active] 983545010528 Presynaptic Site I dimer interface [polypeptide binding]; other site 983545010529 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 983545010530 Synaptic Flat tetramer interface [polypeptide binding]; other site 983545010531 Synaptic Site I dimer interface [polypeptide binding]; other site 983545010532 DNA binding site [nucleotide binding] 983545010533 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545010534 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545010535 Phage integrase family; Region: Phage_integrase; pfam00589 983545010536 DNA binding site [nucleotide binding] 983545010537 Int/Topo IB signature motif; other site 983545010538 active site 983545010539 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 983545010540 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 983545010541 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545010542 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010543 metal binding site [ion binding]; metal-binding site 983545010544 active site 983545010545 I-site; other site 983545010546 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 983545010547 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 983545010548 Walker A/P-loop; other site 983545010549 ATP binding site [chemical binding]; other site 983545010550 Q-loop/lid; other site 983545010551 ABC transporter signature motif; other site 983545010552 Walker B; other site 983545010553 D-loop; other site 983545010554 H-loop/switch region; other site 983545010555 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545010556 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 983545010557 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 983545010558 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 983545010559 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545010560 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010561 N-terminal plug; other site 983545010562 ligand-binding site [chemical binding]; other site 983545010563 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 983545010564 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 983545010565 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 983545010566 active site 983545010567 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 983545010568 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010569 N-terminal plug; other site 983545010570 ligand-binding site [chemical binding]; other site 983545010571 Late embryogenesis abundant protein; Region: LEA_2; cl12118 983545010572 Cytochrome b562; Region: Cytochrom_B562; cl01546 983545010573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545010574 membrane-bound complex binding site; other site 983545010575 hinge residues; other site 983545010576 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545010577 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 983545010578 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010579 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010580 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 983545010581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010582 binding surface 983545010583 TPR motif; other site 983545010584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010585 binding surface 983545010586 TPR motif; other site 983545010587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010588 binding surface 983545010589 TPR motif; other site 983545010590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010591 TPR motif; other site 983545010592 binding surface 983545010593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010594 binding surface 983545010595 TPR motif; other site 983545010596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010597 TPR motif; other site 983545010598 binding surface 983545010599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010600 TPR motif; other site 983545010601 binding surface 983545010602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010603 binding surface 983545010604 TPR motif; other site 983545010605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545010606 binding surface 983545010607 TPR motif; other site 983545010608 NodT family; Region: outer_NodT; TIGR01845 983545010609 Outer membrane efflux protein; Region: OEP; pfam02321 983545010610 Outer membrane efflux protein; Region: OEP; pfam02321 983545010611 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 983545010612 Protein export membrane protein; Region: SecD_SecF; cl14618 983545010613 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 983545010614 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 983545010615 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 983545010616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545010617 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 983545010618 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545010619 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 983545010620 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545010621 enoyl-CoA hydratase; Provisional; Region: PRK06688 983545010622 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545010623 substrate binding site [chemical binding]; other site 983545010624 oxyanion hole (OAH) forming residues; other site 983545010625 trimer interface [polypeptide binding]; other site 983545010626 Predicted transcription regulator, contains HTH domain (MarR family) [Transcription]; Region: COG5631 983545010627 5-oxoprolinase; Region: PLN02666 983545010628 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 983545010629 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 983545010630 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 983545010631 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 983545010632 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545010633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010634 putative substrate translocation pore; other site 983545010635 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010636 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010637 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545010638 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 983545010639 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 983545010640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545010641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545010642 DNA binding site [nucleotide binding] 983545010643 domain linker motif; other site 983545010644 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 983545010645 putative ligand binding site [chemical binding]; other site 983545010646 putative dimerization interface [polypeptide binding]; other site 983545010647 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545010648 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 983545010649 C-terminal domain interface [polypeptide binding]; other site 983545010650 GSH binding site (G-site) [chemical binding]; other site 983545010651 dimer interface [polypeptide binding]; other site 983545010652 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 983545010653 N-terminal domain interface [polypeptide binding]; other site 983545010654 dimer interface [polypeptide binding]; other site 983545010655 substrate binding pocket (H-site) [chemical binding]; other site 983545010656 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 983545010657 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 983545010658 putative active site [active] 983545010659 PhoH-like protein; Region: PhoH; cl12134 983545010660 ATP-dependent helicase HepA; Validated; Region: PRK04914 983545010661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545010662 ATP binding site [chemical binding]; other site 983545010663 putative Mg++ binding site [ion binding]; other site 983545010664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545010665 nucleotide binding region [chemical binding]; other site 983545010666 ATP-binding site [chemical binding]; other site 983545010667 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 983545010668 active site 983545010669 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 983545010670 muropeptide transporter; Reviewed; Region: ampG; PRK11902 983545010671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 983545010672 PAS fold; Region: PAS_4; pfam08448 983545010673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010674 metal binding site [ion binding]; metal-binding site 983545010675 active site 983545010676 I-site; other site 983545010677 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010679 active site 983545010680 phosphorylation site [posttranslational modification] 983545010681 intermolecular recognition site; other site 983545010682 dimerization interface [polypeptide binding]; other site 983545010683 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 983545010684 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 983545010685 dimerization interface [polypeptide binding]; other site 983545010686 active site 983545010687 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 983545010688 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 983545010689 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 983545010690 Ferritin-like domain; Region: Ferritin; pfam00210 983545010691 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 983545010692 dimerization interface [polypeptide binding]; other site 983545010693 DPS ferroxidase diiron center [ion binding]; other site 983545010694 ion pore; other site 983545010695 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 983545010696 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 983545010697 NADP binding site [chemical binding]; other site 983545010698 active site 983545010699 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 983545010700 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545010701 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 983545010702 GAF domain; Region: GAF; cl00853 983545010703 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 983545010704 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 983545010705 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 983545010706 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 983545010707 putative active site [active] 983545010708 Ap4A binding site [chemical binding]; other site 983545010709 nudix motif; other site 983545010710 putative metal binding site [ion binding]; other site 983545010711 YhhN-like protein; Region: YhhN; cl01505 983545010712 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex; Region: MutH_Sau3AI; cd00583 983545010713 putative DNA-binding cleft [nucleotide binding]; other site 983545010714 putative DNA clevage site; other site 983545010715 molecular lever; other site 983545010716 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545010717 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 983545010718 NAD(P) binding site [chemical binding]; other site 983545010719 catalytic residues [active] 983545010720 acetolactate synthase; Reviewed; Region: PRK08322 983545010721 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 983545010722 PYR/PP interface [polypeptide binding]; other site 983545010723 dimer interface [polypeptide binding]; other site 983545010724 TPP binding site [chemical binding]; other site 983545010725 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 983545010726 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 983545010727 TPP-binding site [chemical binding]; other site 983545010728 dimer interface [polypeptide binding]; other site 983545010729 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 983545010730 putative active site [active] 983545010731 putative metal binding residues [ion binding]; other site 983545010732 signature motif; other site 983545010733 putative triphosphate binding site [ion binding]; other site 983545010734 SH3 domain-containing protein; Provisional; Region: PRK10884 983545010735 Bacterial SH3 domain; Region: SH3_3; cl02551 983545010736 LysE type translocator; Region: LysE; cl00565 983545010737 TIGR03546 family protein; Region: TIGR03546 983545010738 TIGR03545 family protein; Region: TIGR03545 983545010739 Septum formation initiator; Region: DivIC; cl11433 983545010740 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 983545010741 substrate binding site [chemical binding]; other site 983545010742 dimer interface [polypeptide binding]; other site 983545010743 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 983545010744 homotrimer interaction site [polypeptide binding]; other site 983545010745 zinc binding site [ion binding]; other site 983545010746 CDP-binding sites; other site 983545010747 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 983545010748 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 983545010749 Permutation of conserved domain; other site 983545010750 active site 983545010751 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 983545010752 Survival protein SurE; Region: SurE; cl00448 983545010753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545010754 Domain of unknown function (DUF368); Region: DUF368; cl00893 983545010755 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 983545010756 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 983545010757 putative peptidoglycan binding site; other site 983545010758 Peptidase family M23; Region: Peptidase_M23; pfam01551 983545010759 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 983545010760 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545010761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545010762 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 983545010763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 983545010764 DNA binding residues [nucleotide binding] 983545010765 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 983545010766 putative hydrolase; Validated; Region: PRK09248 983545010767 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 983545010768 RNase P subunit p30; Region: RNase_P_p30; cl03389 983545010769 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 983545010770 nucleoside/Zn binding site; other site 983545010771 dimer interface [polypeptide binding]; other site 983545010772 catalytic motif [active] 983545010773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545010774 non-specific DNA binding site [nucleotide binding]; other site 983545010775 salt bridge; other site 983545010776 sequence-specific DNA binding site [nucleotide binding]; other site 983545010777 Predicted amidohydrolase [General function prediction only]; Region: COG0388 983545010778 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 983545010779 putative active site [active] 983545010780 catalytic triad [active] 983545010781 putative dimer interface [polypeptide binding]; other site 983545010782 arginine decarboxylase; Provisional; Region: PRK05354 983545010783 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 983545010784 dimer interface [polypeptide binding]; other site 983545010785 active site 983545010786 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 983545010787 catalytic residues [active] 983545010788 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 983545010789 Beta-lactamase; Region: Beta-lactamase; cl01009 983545010790 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 983545010791 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 983545010792 AlkA N-terminal domain; Region: AlkA_N; pfam06029 983545010793 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 983545010794 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 983545010795 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 983545010796 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 983545010797 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 983545010798 DNA binding site [nucleotide binding] 983545010799 active site 983545010800 EamA-like transporter family; Region: EamA; cl01037 983545010801 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 983545010802 EamA-like transporter family; Region: EamA; cl01037 983545010803 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010804 metal binding site [ion binding]; metal-binding site 983545010805 active site 983545010806 I-site; other site 983545010807 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 983545010808 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 983545010809 Substrate binding site [chemical binding]; other site 983545010810 Mg++ binding site [ion binding]; other site 983545010811 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 983545010812 active site 983545010813 substrate binding site [chemical binding]; other site 983545010814 CoA binding site [chemical binding]; other site 983545010815 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 983545010816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545010817 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 983545010818 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 983545010819 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 983545010820 glutaminase active site [active] 983545010821 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 983545010822 dimer interface [polypeptide binding]; other site 983545010823 active site 983545010824 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 983545010825 dimer interface [polypeptide binding]; other site 983545010826 active site 983545010827 HsdM N-terminal domain; Region: HsdM_N; pfam12161 983545010828 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 983545010829 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 983545010830 Fic/DOC family; Region: Fic; cl00960 983545010831 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 983545010832 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 983545010833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 983545010834 ATP binding site [chemical binding]; other site 983545010835 putative Mg++ binding site [ion binding]; other site 983545010836 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 983545010837 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 983545010838 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 983545010839 Archaeal ATPase; Region: Arch_ATPase; pfam01637 983545010840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545010841 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545010842 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545010843 N-terminal plug; other site 983545010844 ligand-binding site [chemical binding]; other site 983545010845 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545010846 classical (c) SDRs; Region: SDR_c; cd05233 983545010847 NAD(P) binding site [chemical binding]; other site 983545010848 active site 983545010849 hypothetical protein; Provisional; Region: PRK06194 983545010850 classical (c) SDRs; Region: SDR_c; cd05233 983545010851 NAD(P) binding site [chemical binding]; other site 983545010852 active site 983545010853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545010854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545010855 enoyl-CoA hydratase; Provisional; Region: PRK08140 983545010856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545010857 substrate binding site [chemical binding]; other site 983545010858 oxyanion hole (OAH) forming residues; other site 983545010859 trimer interface [polypeptide binding]; other site 983545010860 aldehyde dehydrogenase; Provisional; Region: PRK11903 983545010861 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 983545010862 substrate binding site [chemical binding]; other site 983545010863 dimer interface [polypeptide binding]; other site 983545010864 NADP binding site [chemical binding]; other site 983545010865 catalytic residues [active] 983545010866 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 983545010867 Strictosidine synthase; Region: Str_synth; pfam03088 983545010868 enoyl-CoA hydratase; Provisional; Region: PRK06494 983545010869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545010870 substrate binding site [chemical binding]; other site 983545010871 oxyanion hole (OAH) forming residues; other site 983545010872 trimer interface [polypeptide binding]; other site 983545010873 CoA-transferase family III; Region: CoA_transf_3; cl00778 983545010874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545010875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545010876 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 983545010877 ligand binding site [chemical binding]; other site 983545010878 coregulator recognition site; other site 983545010879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545010880 D-galactonate transporter; Region: 2A0114; TIGR00893 983545010881 putative substrate translocation pore; other site 983545010882 acyl-CoA synthetase; Provisional; Region: PRK12582 983545010883 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545010884 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 983545010885 active site 983545010886 catalytic site [active] 983545010887 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545010888 active site 2 [active] 983545010889 active site 1 [active] 983545010890 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 983545010891 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 983545010892 active site 983545010893 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 983545010894 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545010895 active site 983545010896 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 983545010897 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545010898 dimer interface [polypeptide binding]; other site 983545010899 active site 983545010900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545010901 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 983545010902 substrate binding site [chemical binding]; other site 983545010903 oxyanion hole (OAH) forming residues; other site 983545010904 trimer interface [polypeptide binding]; other site 983545010905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545010906 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545010907 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545010908 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 983545010909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545010910 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 983545010911 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545010912 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 983545010913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545010914 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545010915 active site 983545010916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545010917 metal binding site [ion binding]; metal-binding site 983545010918 active site 983545010919 I-site; other site 983545010920 Protein of unknown function (DUF445); Region: DUF445; pfam04286 983545010921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545010922 dimer interface [polypeptide binding]; other site 983545010923 phosphorylation site [posttranslational modification] 983545010924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010925 ATP binding site [chemical binding]; other site 983545010926 Mg2+ binding site [ion binding]; other site 983545010927 G-X-G motif; other site 983545010928 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010930 active site 983545010931 phosphorylation site [posttranslational modification] 983545010932 intermolecular recognition site; other site 983545010933 dimerization interface [polypeptide binding]; other site 983545010934 Response regulator receiver domain; Region: Response_reg; pfam00072 983545010935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010936 active site 983545010937 phosphorylation site [posttranslational modification] 983545010938 intermolecular recognition site; other site 983545010939 dimerization interface [polypeptide binding]; other site 983545010940 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 983545010941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545010942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545010943 dimerization interface [polypeptide binding]; other site 983545010944 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545010945 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 983545010946 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 983545010947 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 983545010948 putative ligand binding site [chemical binding]; other site 983545010949 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545010950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545010951 dimer interface [polypeptide binding]; other site 983545010952 phosphorylation site [posttranslational modification] 983545010953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545010954 ATP binding site [chemical binding]; other site 983545010955 Mg2+ binding site [ion binding]; other site 983545010956 G-X-G motif; other site 983545010957 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 983545010958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545010959 active site 983545010960 phosphorylation site [posttranslational modification] 983545010961 intermolecular recognition site; other site 983545010962 dimerization interface [polypeptide binding]; other site 983545010963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545010964 DNA binding site [nucleotide binding] 983545010965 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 983545010966 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545010967 ligand binding site [chemical binding]; other site 983545010968 Vault protein inter-alpha-trypsin; Region: VIT; cl02699 983545010969 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 983545010970 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 983545010971 metal ion-dependent adhesion site (MIDAS); other site 983545010972 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_4; cd05828 983545010973 active site 983545010974 catalytic site [active] 983545010975 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545010976 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 983545010977 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 983545010978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545010979 Walker A/P-loop; other site 983545010980 ATP binding site [chemical binding]; other site 983545010981 Q-loop/lid; other site 983545010982 ABC transporter signature motif; other site 983545010983 Walker B; other site 983545010984 D-loop; other site 983545010985 H-loop/switch region; other site 983545010986 ABC-2 type transporter; Region: ABC2_membrane; cl11417 983545010987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545010988 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545010989 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 983545010990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 983545010991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 983545010992 catalytic residue [active] 983545010993 pantoate--beta-alanine ligase; Region: panC; TIGR00018 983545010994 Pantoate-beta-alanine ligase; Region: PanC; cd00560 983545010995 active site 983545010996 ATP-binding site [chemical binding]; other site 983545010997 pantoate-binding site; other site 983545010998 HXXH motif; other site 983545010999 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 983545011000 oligomerization interface [polypeptide binding]; other site 983545011001 active site 983545011002 metal binding site [ion binding]; metal-binding site 983545011003 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 983545011004 catalytic center binding site [active] 983545011005 ATP binding site [chemical binding]; other site 983545011006 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 983545011007 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 983545011008 active site 983545011009 NTP binding site [chemical binding]; other site 983545011010 metal binding triad [ion binding]; metal-binding site 983545011011 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 983545011012 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 983545011013 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545011014 active site 983545011015 HIGH motif; other site 983545011016 nucleotide binding site [chemical binding]; other site 983545011017 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 983545011018 KMSKS motif; other site 983545011019 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 983545011020 Sugar fermentation stimulation protein; Region: SfsA; cl00647 983545011021 aminopeptidase B; Provisional; Region: PRK05015 983545011022 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 983545011023 interface (dimer of trimers) [polypeptide binding]; other site 983545011024 Substrate-binding/catalytic site; other site 983545011025 Zn-binding sites [ion binding]; other site 983545011026 MarC family integral membrane protein; Region: MarC; cl00919 983545011027 Protein of unknown function (DUF416); Region: DUF416; cl01166 983545011028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545011029 S-adenosylmethionine binding site [chemical binding]; other site 983545011030 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 983545011031 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 983545011032 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 983545011033 P loop; other site 983545011034 GTP binding site [chemical binding]; other site 983545011035 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 983545011036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545011037 Walker A/P-loop; other site 983545011038 ATP binding site [chemical binding]; other site 983545011039 Q-loop/lid; other site 983545011040 ABC transporter signature motif; other site 983545011041 Walker B; other site 983545011042 D-loop; other site 983545011043 H-loop/switch region; other site 983545011044 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 983545011045 FtsX-like permease family; Region: FtsX; pfam02687 983545011046 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 983545011047 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 983545011048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 983545011049 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 983545011050 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 983545011051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545011052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 983545011053 acyl-CoA synthetase; Validated; Region: PRK08316 983545011054 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545011055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011056 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 983545011057 NAD(P) binding site [chemical binding]; other site 983545011058 active site 983545011059 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 983545011060 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 983545011061 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 983545011062 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545011063 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 983545011064 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 983545011065 carboxyltransferase (CT) interaction site; other site 983545011066 biotinylation site [posttranslational modification]; other site 983545011067 enoyl-CoA hydratase; Provisional; Region: PRK05995 983545011068 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545011069 substrate binding site [chemical binding]; other site 983545011070 oxyanion hole (OAH) forming residues; other site 983545011071 trimer interface [polypeptide binding]; other site 983545011072 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 983545011073 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 983545011074 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 983545011075 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 983545011076 FMN binding site [chemical binding]; other site 983545011077 substrate binding site [chemical binding]; other site 983545011078 putative catalytic residue [active] 983545011079 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 983545011080 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 983545011081 active site 983545011082 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 983545011083 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 983545011084 conserved cys residue [active] 983545011085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011087 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545011088 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 983545011089 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011090 N-terminal plug; other site 983545011091 ligand-binding site [chemical binding]; other site 983545011092 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 983545011093 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 983545011094 active site 983545011095 HIGH motif; other site 983545011096 dimer interface [polypeptide binding]; other site 983545011097 KMSKS motif; other site 983545011098 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545011099 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545011100 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 983545011101 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 983545011102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545011103 Walker A/P-loop; other site 983545011104 ATP binding site [chemical binding]; other site 983545011105 Q-loop/lid; other site 983545011106 ABC transporter signature motif; other site 983545011107 Walker B; other site 983545011108 D-loop; other site 983545011109 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545011110 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545011111 Outer membrane efflux protein; Region: OEP; pfam02321 983545011112 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 983545011113 glutamate dehydrogenase; Provisional; Region: PRK09414 983545011114 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 983545011115 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 983545011116 NAD(P) binding site [chemical binding]; other site 983545011117 C-term; Region: GreA_GreB; pfam01272 983545011118 Sodium:solute symporter family; Region: SSF; cl00456 983545011119 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 983545011120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011121 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 983545011122 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion...; Region: enolase_like; cl14814 983545011123 metal binding site [ion binding]; metal-binding site 983545011124 substrate binding pocket [chemical binding]; other site 983545011125 Transcriptional regulators [Transcription]; Region: PurR; COG1609 983545011126 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 983545011127 DNA binding site [nucleotide binding] 983545011128 domain linker motif; other site 983545011129 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 983545011130 dimerization interface [polypeptide binding]; other site 983545011131 ligand binding site [chemical binding]; other site 983545011132 choline transport protein BetT; Provisional; Region: PRK09928 983545011133 BCCT family transporter; Region: BCCT; cl00569 983545011134 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 983545011135 MAPEG family; Region: MAPEG; cl09190 983545011136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545011137 cofactor binding site; other site 983545011138 DNA binding site [nucleotide binding] 983545011139 substrate interaction site [chemical binding]; other site 983545011140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545011141 AIPR protein; Region: AIPR; pfam10592 983545011142 Z1 domain; Region: Z1; pfam10593 983545011143 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 983545011144 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 983545011145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545011146 S-adenosylmethionine binding site [chemical binding]; other site 983545011147 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 983545011148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 983545011149 non-specific DNA binding site [nucleotide binding]; other site 983545011150 salt bridge; other site 983545011151 sequence-specific DNA binding site [nucleotide binding]; other site 983545011152 HipA-like N-terminal domain; Region: HipA_N; pfam07805 983545011153 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545011154 Secretin and TonB N terminus short domain; Region: STN; pfam07660 983545011155 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545011156 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545011157 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011158 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 983545011159 FecR protein; Region: FecR; pfam04773 983545011160 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 983545011161 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 983545011162 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 983545011163 DNA binding residues [nucleotide binding] 983545011164 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 983545011165 active site 983545011166 metal binding site [ion binding]; metal-binding site 983545011167 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545011168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011169 metal binding site [ion binding]; metal-binding site 983545011170 active site 983545011171 I-site; other site 983545011172 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545011173 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 983545011174 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011175 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 983545011176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545011177 putative PBP binding loops; other site 983545011178 ABC-ATPase subunit interface; other site 983545011179 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 983545011180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 983545011181 dimer interface [polypeptide binding]; other site 983545011182 conserved gate region; other site 983545011183 putative PBP binding loops; other site 983545011184 ABC-ATPase subunit interface; other site 983545011185 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 983545011186 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 983545011187 Walker A/P-loop; other site 983545011188 ATP binding site [chemical binding]; other site 983545011189 Q-loop/lid; other site 983545011190 ABC transporter signature motif; other site 983545011191 Walker B; other site 983545011192 D-loop; other site 983545011193 H-loop/switch region; other site 983545011194 TOBE domain; Region: TOBE_2; cl01440 983545011195 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 983545011196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 983545011197 motif II; other site 983545011198 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 983545011199 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 983545011200 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 983545011201 putative substrate binding site [chemical binding]; other site 983545011202 putative ATP binding site [chemical binding]; other site 983545011203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 983545011204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545011205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545011208 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545011209 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 983545011210 NodT family; Region: outer_NodT; TIGR01845 983545011211 Outer membrane efflux protein; Region: OEP; pfam02321 983545011212 Outer membrane efflux protein; Region: OEP; pfam02321 983545011213 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545011214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011215 putative substrate translocation pore; other site 983545011216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545011218 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545011219 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 983545011220 putative C-terminal domain interface [polypeptide binding]; other site 983545011221 putative GSH binding site (G-site) [chemical binding]; other site 983545011222 putative dimer interface [polypeptide binding]; other site 983545011223 GST_C family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_C_GTT2_like; cd03182 983545011224 putative N-terminal domain interface [polypeptide binding]; other site 983545011225 putative dimer interface [polypeptide binding]; other site 983545011226 putative substrate binding pocket (H-site) [chemical binding]; other site 983545011227 Cupin domain; Region: Cupin_2; cl09118 983545011228 periplasmic protein; Provisional; Region: PRK10568 983545011229 BON domain; Region: BON; cl02771 983545011230 BON domain; Region: BON; cl02771 983545011231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 983545011232 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 983545011233 active site 983545011234 catalytic tetrad [active] 983545011235 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 983545011236 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 983545011237 putative catalytic site [active] 983545011238 putative metal binding site [ion binding]; other site 983545011239 putative phosphate binding site [ion binding]; other site 983545011240 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 983545011241 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 983545011242 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 983545011243 Mechanosensitive ion channel; Region: MS_channel; pfam00924 983545011244 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 983545011245 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 983545011246 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 983545011247 putative catalytic cysteine [active] 983545011248 gamma-glutamyl kinase; Provisional; Region: PRK13402 983545011249 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 983545011250 nucleotide binding site [chemical binding]; other site 983545011251 homotetrameric interface [polypeptide binding]; other site 983545011252 putative phosphate binding site [ion binding]; other site 983545011253 putative allosteric binding site; other site 983545011254 PUA domain; Region: PUA; cl00607 983545011255 Sodium:solute symporter family; Region: SSF; cl00456 983545011256 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545011257 Transcriptional regulators [Transcription]; Region: MarR; COG1846 983545011258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545011259 VacJ like lipoprotein; Region: VacJ; cl01073 983545011260 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 983545011261 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545011262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545011263 active site 983545011264 phosphorylation site [posttranslational modification] 983545011265 intermolecular recognition site; other site 983545011266 dimerization interface [polypeptide binding]; other site 983545011267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545011268 dimer interface [polypeptide binding]; other site 983545011269 phosphorylation site [posttranslational modification] 983545011270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011271 ATP binding site [chemical binding]; other site 983545011272 Mg2+ binding site [ion binding]; other site 983545011273 G-X-G motif; other site 983545011274 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545011275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545011276 active site 983545011277 phosphorylation site [posttranslational modification] 983545011278 intermolecular recognition site; other site 983545011279 dimerization interface [polypeptide binding]; other site 983545011280 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545011282 active site 983545011283 phosphorylation site [posttranslational modification] 983545011284 intermolecular recognition site; other site 983545011285 dimerization interface [polypeptide binding]; other site 983545011286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545011287 active site 983545011288 phosphorylation site [posttranslational modification] 983545011289 intermolecular recognition site; other site 983545011290 dimerization interface [polypeptide binding]; other site 983545011291 CHASE3 domain; Region: CHASE3; cl05000 983545011292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 983545011293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011294 ATP binding site [chemical binding]; other site 983545011295 Mg2+ binding site [ion binding]; other site 983545011296 G-X-G motif; other site 983545011297 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 983545011298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545011299 active site 983545011300 phosphorylation site [posttranslational modification] 983545011301 intermolecular recognition site; other site 983545011302 dimerization interface [polypeptide binding]; other site 983545011303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545011304 Walker A motif; other site 983545011305 ATP binding site [chemical binding]; other site 983545011306 Walker B motif; other site 983545011307 arginine finger; other site 983545011308 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 983545011309 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 983545011310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545011311 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 983545011312 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 983545011313 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545011314 Beta-lactamase; Region: Beta-lactamase; cl01009 983545011315 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 983545011316 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 983545011317 amidase catalytic site [active] 983545011318 Zn binding residues [ion binding]; other site 983545011319 substrate binding site [chemical binding]; other site 983545011320 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 983545011321 Beta-lactamase; Region: Beta-lactamase; cl01009 983545011322 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 983545011323 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 983545011324 nudix motif; other site 983545011325 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 983545011326 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 983545011327 putative active site [active] 983545011328 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545011329 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545011330 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 983545011331 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 983545011332 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 983545011333 putative active site [active] 983545011334 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 983545011335 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 983545011336 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 983545011337 Sodium:solute symporter family; Region: SSF; cl00456 983545011338 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 983545011339 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 983545011340 NlpC/P60 family; Region: NLPC_P60; cl11438 983545011341 Protein of unknown function (DUF819); Region: DUF819; cl02317 983545011342 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 983545011343 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 983545011344 dimer interface [polypeptide binding]; other site 983545011345 active site 983545011346 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 983545011347 dimer interface [polypeptide binding]; other site 983545011348 active site 983545011349 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 983545011350 active site 983545011351 dimer interface [polypeptide binding]; other site 983545011352 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 983545011353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 983545011354 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 983545011355 dimer interface [polypeptide binding]; other site 983545011356 catalytic triad [active] 983545011357 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545011359 active site 983545011360 phosphorylation site [posttranslational modification] 983545011361 intermolecular recognition site; other site 983545011362 dimerization interface [polypeptide binding]; other site 983545011363 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011364 metal binding site [ion binding]; metal-binding site 983545011365 active site 983545011366 I-site; other site 983545011367 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 983545011368 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 983545011369 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 983545011370 ABC transporter; Region: ABC_tran_2; pfam12848 983545011371 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 983545011372 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545011373 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545011374 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 983545011375 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 983545011376 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 983545011377 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 983545011378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545011380 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 983545011381 Malic enzyme, N-terminal domain; Region: malic; pfam00390 983545011382 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 983545011383 putative NAD(P) binding site [chemical binding]; other site 983545011384 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 983545011385 primosome assembly protein PriA; Validated; Region: PRK05580 983545011386 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 983545011387 ATP binding site [chemical binding]; other site 983545011388 putative Mg++ binding site [ion binding]; other site 983545011389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 983545011390 cell division protein FtsN; Region: ftsN; TIGR02223 983545011391 Sporulation related domain; Region: SPOR; cl10051 983545011392 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 983545011393 active site 983545011394 HslU subunit interaction site [polypeptide binding]; other site 983545011395 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 983545011396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545011397 Walker A motif; other site 983545011398 ATP binding site [chemical binding]; other site 983545011399 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545011400 Beta-lactamase; Region: Beta-lactamase; cl01009 983545011401 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 983545011402 putative active site [active] 983545011403 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 983545011404 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 983545011405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545011406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011407 dimerization interface [polypeptide binding]; other site 983545011408 Bacterial SH3 domain; Region: SH3_3; cl02551 983545011409 Bacterial SH3 domain; Region: SH3_3; cl02551 983545011410 Bacterial SH3 domain; Region: SH3_3; cl02551 983545011411 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 983545011412 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 983545011413 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 983545011414 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 983545011415 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 983545011416 Protein export membrane protein; Region: SecD_SecF; cl14618 983545011417 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021 983545011418 Protein export membrane protein; Region: SecD_SecF; cl14618 983545011419 Uncharacterised ACR, YagE family COG1723; Region: DUF155; cl00751 983545011420 glutathione reductase; Validated; Region: PRK06116 983545011421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545011422 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545011423 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 983545011424 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 983545011425 active site 983545011426 Zn binding site [ion binding]; other site 983545011427 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 983545011428 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 983545011429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 983545011430 S-adenosylmethionine binding site [chemical binding]; other site 983545011431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 983545011432 SCP-2 sterol transfer family; Region: SCP2; cl01225 983545011433 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 983545011434 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 983545011435 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545011436 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 983545011437 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 983545011438 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 983545011439 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 983545011440 active site 983545011441 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 983545011442 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 983545011443 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545011444 chromosome segregation protein; Provisional; Region: PRK02224 983545011445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011446 metal binding site [ion binding]; metal-binding site 983545011447 active site 983545011448 I-site; other site 983545011449 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 983545011450 dimer interface [polypeptide binding]; other site 983545011451 active site 983545011452 aspartate-rich active site metal binding site; other site 983545011453 allosteric magnesium binding site [ion binding]; other site 983545011454 Schiff base residues; other site 983545011455 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 983545011456 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 983545011457 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 983545011458 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 983545011459 ATP binding site [chemical binding]; other site 983545011460 Mg++ binding site [ion binding]; other site 983545011461 motif III; other site 983545011462 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 983545011463 nucleotide binding region [chemical binding]; other site 983545011464 ATP-binding site [chemical binding]; other site 983545011465 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 983545011466 catalytic residues [active] 983545011467 transcription termination factor Rho; Provisional; Region: rho; PRK09376 983545011468 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 983545011469 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 983545011470 RNA binding site [nucleotide binding]; other site 983545011471 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 983545011472 multimer interface [polypeptide binding]; other site 983545011473 Walker A motif; other site 983545011474 ATP binding site [chemical binding]; other site 983545011475 Walker B motif; other site 983545011476 AIR carboxylase; Region: AIRC; cl00310 983545011477 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 983545011478 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 983545011479 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 983545011480 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 983545011481 dimer interface [polypeptide binding]; other site 983545011482 active site 983545011483 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 983545011484 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 983545011485 substrate binding site [chemical binding]; other site 983545011486 oxyanion hole (OAH) forming residues; other site 983545011487 trimer interface [polypeptide binding]; other site 983545011488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011489 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545011490 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 983545011491 lytic murein transglycosylase; Provisional; Region: PRK11619 983545011492 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 983545011493 N-acetyl-D-glucosamine binding site [chemical binding]; other site 983545011494 catalytic residue [active] 983545011495 proline dipeptidase; Provisional; Region: PRK13607 983545011496 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 983545011497 active site 983545011498 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 983545011499 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 983545011500 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 983545011501 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 983545011502 putative C-terminal domain interface [polypeptide binding]; other site 983545011503 putative GSH binding site (G-site) [chemical binding]; other site 983545011504 putative dimer interface [polypeptide binding]; other site 983545011505 GST_C family, unknown subfamily 1; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_1; cd03179 983545011506 putative N-terminal domain interface [polypeptide binding]; other site 983545011507 putative dimer interface [polypeptide binding]; other site 983545011508 putative substrate binding pocket (H-site) [chemical binding]; other site 983545011509 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 983545011510 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 983545011511 Protein of unknown function (DUF615); Region: DUF615; cl01147 983545011512 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 983545011513 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 983545011514 Predicted amidohydrolase [General function prediction only]; Region: COG0388 983545011515 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 983545011516 putative active site [active] 983545011517 catalytic triad [active] 983545011518 dimer interface [polypeptide binding]; other site 983545011519 TIGR02099 family protein; Region: TIGR02099 983545011520 ribonuclease G; Provisional; Region: PRK11712 983545011521 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 983545011522 homodimer interface [polypeptide binding]; other site 983545011523 oligonucleotide binding site [chemical binding]; other site 983545011524 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 983545011525 active site 983545011526 dimer interface [polypeptide binding]; other site 983545011527 rod shape-determining protein MreD; Region: MreD; cl01087 983545011528 rod shape-determining protein MreC; Provisional; Region: PRK13922 983545011529 rod shape-determining protein MreC; Region: MreC; pfam04085 983545011530 rod shape-determining protein MreB; Provisional; Region: PRK13927 983545011531 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 983545011532 ATP binding site [chemical binding]; other site 983545011533 profilin binding site; other site 983545011534 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 983545011535 heterodimerization interface [polypeptide binding]; other site 983545011536 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 983545011537 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545011538 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 983545011539 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 983545011540 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 983545011541 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 983545011542 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 983545011543 Walker A motif; other site 983545011544 ATP binding site [chemical binding]; other site 983545011545 Walker B motif; other site 983545011546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545011547 binding surface 983545011548 TPR motif; other site 983545011549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 983545011550 TPR motif; other site 983545011551 binding surface 983545011552 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 983545011553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 983545011554 Walker A motif; other site 983545011555 ATP binding site [chemical binding]; other site 983545011556 Walker B motif; other site 983545011557 arginine finger; other site 983545011558 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 983545011559 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 983545011560 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 983545011561 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 983545011562 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 983545011563 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 983545011564 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 983545011565 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 983545011566 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 983545011567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 983545011568 inhibitor-cofactor binding pocket; inhibition site 983545011569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545011570 catalytic residue [active] 983545011571 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 983545011572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545011573 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 983545011574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545011575 active site 983545011576 phosphorylation site [posttranslational modification] 983545011577 intermolecular recognition site; other site 983545011578 dimerization interface [polypeptide binding]; other site 983545011579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011580 metal binding site [ion binding]; metal-binding site 983545011581 active site 983545011582 I-site; other site 983545011583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 983545011584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 983545011585 methylamine dehydrogenase heavy chain; Region: TTQ_MADH_Hv; TIGR02658 983545011586 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545011587 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 983545011588 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 983545011589 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 983545011590 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011591 N-terminal plug; other site 983545011592 ligand-binding site [chemical binding]; other site 983545011593 AMP-binding domain protein; Validated; Region: PRK08315 983545011594 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 983545011595 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 983545011596 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 983545011597 NAD(P) binding site [chemical binding]; other site 983545011598 catalytic residues [active] 983545011599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545011600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545011601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 983545011602 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 983545011603 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 983545011604 N-terminal plug; other site 983545011605 ligand-binding site [chemical binding]; other site 983545011606 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 983545011607 dimer interface [polypeptide binding]; other site 983545011608 ssDNA binding site [nucleotide binding]; other site 983545011609 tetramer (dimer of dimers) interface [polypeptide binding]; other site 983545011610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 983545011612 putative substrate translocation pore; other site 983545011613 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 983545011614 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 983545011615 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 983545011616 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 983545011617 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 983545011618 active site 983545011619 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 983545011620 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 983545011621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011622 putative substrate translocation pore; other site 983545011623 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 983545011624 dimer interface [polypeptide binding]; other site 983545011625 substrate binding site [chemical binding]; other site 983545011626 metal binding sites [ion binding]; metal-binding site 983545011627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 983545011628 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 983545011629 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 983545011630 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 983545011631 dimer interface [polypeptide binding]; other site 983545011632 ADP-ribose binding site [chemical binding]; other site 983545011633 active site 983545011634 nudix motif; other site 983545011635 metal binding site [ion binding]; metal-binding site 983545011636 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 983545011637 active site 983545011638 YceI-like domain; Region: YceI; cl01001 983545011639 Uncharacterised protein family (UPF0270); Region: UPF0270; cl01180 983545011640 putative hydrolase; Provisional; Region: PRK10985 983545011641 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 983545011642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545011643 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 983545011644 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 983545011645 putative dimerization interface [polypeptide binding]; other site 983545011646 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 983545011647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545011648 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 983545011649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545011650 Walker A/P-loop; other site 983545011651 ATP binding site [chemical binding]; other site 983545011652 Q-loop/lid; other site 983545011653 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 983545011654 ABC transporter; Region: ABC_tran_2; pfam12848 983545011655 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 983545011656 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 983545011657 SlyX; Region: SlyX; cl01090 983545011658 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 983545011659 structural tetrad; other site 983545011660 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 983545011661 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 983545011662 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 983545011663 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 983545011664 domain; Region: GreA_GreB_N; pfam03449 983545011665 C-term; Region: GreA_GreB; pfam01272 983545011666 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 983545011667 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 983545011668 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 983545011669 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 983545011670 RNA binding site [nucleotide binding]; other site 983545011671 SprA-related family; Region: SprA-related; pfam12118 983545011672 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 983545011673 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 983545011674 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 983545011675 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_1; cd06238 983545011676 putative active site [active] 983545011677 Zn-binding site [ion binding]; other site 983545011678 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 983545011679 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 983545011680 NifU-like domain; Region: NifU; cl00484 983545011681 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 983545011682 MatE; Region: MatE; pfam01554 983545011683 MatE; Region: MatE; pfam01554 983545011684 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 983545011685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 983545011686 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 983545011687 Cu(I) binding site [ion binding]; other site 983545011688 UbiA prenyltransferase family; Region: UbiA; cl00337 983545011689 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 983545011690 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 983545011691 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 983545011692 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 983545011693 Subunit III/VIIa interface [polypeptide binding]; other site 983545011694 Phospholipid binding site [chemical binding]; other site 983545011695 Subunit I/III interface [polypeptide binding]; other site 983545011696 Subunit III/VIb interface [polypeptide binding]; other site 983545011697 Subunit III/VIa interface; other site 983545011698 Subunit III/Vb interface [polypeptide binding]; other site 983545011699 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 983545011700 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 983545011701 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 983545011702 Subunit I/III interface [polypeptide binding]; other site 983545011703 D-pathway; other site 983545011704 Subunit I/VIIc interface [polypeptide binding]; other site 983545011705 Subunit I/IV interface [polypeptide binding]; other site 983545011706 Subunit I/II interface [polypeptide binding]; other site 983545011707 Low-spin heme (heme a) binding site [chemical binding]; other site 983545011708 Subunit I/VIIa interface [polypeptide binding]; other site 983545011709 Subunit I/VIa interface [polypeptide binding]; other site 983545011710 Dimer interface; other site 983545011711 Putative water exit pathway; other site 983545011712 Binuclear center (heme a3/CuB) [ion binding]; other site 983545011713 K-pathway; other site 983545011714 Subunit I/Vb interface [polypeptide binding]; other site 983545011715 Putative proton exit pathway; other site 983545011716 Subunit I/VIb interface; other site 983545011717 Subunit I/VIc interface [polypeptide binding]; other site 983545011718 Electron transfer pathway; other site 983545011719 Subunit I/VIIIb interface [polypeptide binding]; other site 983545011720 Subunit I/VIIb interface [polypeptide binding]; other site 983545011721 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 983545011722 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 983545011723 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 983545011724 Cytochrome c [Energy production and conversion]; Region: COG3258 983545011725 Cytochrome c; Region: Cytochrom_C; cl11414 983545011726 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545011727 LexA repressor; Validated; Region: PRK00215 983545011728 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 983545011729 Catalytic site [active] 983545011730 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 983545011731 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 983545011732 putative acyl-acceptor binding pocket; other site 983545011733 threonine dehydratase; Reviewed; Region: PRK09224 983545011734 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 983545011735 tetramer interface [polypeptide binding]; other site 983545011736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 983545011737 catalytic residue [active] 983545011738 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 983545011739 putative Ile/Val binding site [chemical binding]; other site 983545011740 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 983545011741 putative Ile/Val binding site [chemical binding]; other site 983545011742 Dehydratase family; Region: ILVD_EDD; cl00340 983545011743 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 983545011744 Predicted membrane protein [Function unknown]; Region: COG2860 983545011745 UPF0126 domain; Region: UPF0126; pfam03458 983545011746 UPF0126 domain; Region: UPF0126; pfam03458 983545011747 Mg chelatase-related protein; Region: TIGR00368 983545011748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545011749 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 983545011750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545011751 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 983545011752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 983545011753 dimerization interface [polypeptide binding]; other site 983545011754 ketol-acid reductoisomerase; Validated; Region: PRK05225 983545011755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011756 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 983545011757 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 983545011758 putative outer membrane lipoprotein; Provisional; Region: PRK10510 983545011759 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 983545011760 ligand binding site [chemical binding]; other site 983545011761 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 983545011762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011763 putative substrate translocation pore; other site 983545011764 EamA-like transporter family; Region: EamA; cl01037 983545011765 hypothetical protein; Provisional; Region: PRK08262 983545011766 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 983545011767 metal binding site [ion binding]; metal-binding site 983545011768 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 983545011769 Nidogen-like; Region: NIDO; cl02648 983545011770 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 983545011771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545011772 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 983545011773 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 983545011774 putative catalytic cysteine [active] 983545011775 gamma-glutamyl kinase; Provisional; Region: PRK05429 983545011776 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 983545011777 nucleotide binding site [chemical binding]; other site 983545011778 homotetrameric interface [polypeptide binding]; other site 983545011779 putative phosphate binding site [ion binding]; other site 983545011780 putative allosteric binding site; other site 983545011781 PUA domain; Region: PUA; cl00607 983545011782 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 983545011783 Zn binding site [ion binding]; other site 983545011784 Domain of unknown function DUF20; Region: UPF0118; cl00465 983545011785 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 983545011786 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 983545011787 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 983545011788 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 983545011789 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 983545011790 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 983545011791 active site 983545011792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545011793 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 983545011794 CPxP motif; other site 983545011795 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 983545011796 ribonuclease PH; Reviewed; Region: rph; PRK00173 983545011797 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 983545011798 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 983545011799 hypothetical protein; Provisional; Region: PRK11820 983545011800 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 983545011801 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 983545011802 Sulfate transporter family; Region: Sulfate_transp; cl00967 983545011803 Sulfate transporter family; Region: Sulfate_transp; cl00967 983545011804 Sulfate transporter family; Region: Sulfate_transp; cl00967 983545011805 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 983545011806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011807 putative substrate translocation pore; other site 983545011808 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 983545011809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 983545011810 putative substrate translocation pore; other site 983545011811 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 983545011812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545011813 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 983545011814 dimerization interface [polypeptide binding]; other site 983545011815 substrate binding pocket [chemical binding]; other site 983545011816 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 983545011817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 983545011818 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 983545011819 acetoin reductases; Region: 23BDH; TIGR02415 983545011820 NADP binding site [chemical binding]; other site 983545011821 active site 983545011822 steroid binding site; other site 983545011823 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 983545011824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 983545011825 Zn2+ binding site [ion binding]; other site 983545011826 Mg2+ binding site [ion binding]; other site 983545011827 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545011828 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545011829 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545011830 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545011831 SapC; Region: SapC; pfam07277 983545011832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545011833 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 983545011834 DNA binding site [nucleotide binding] 983545011835 active site 983545011836 DTW domain; Region: DTW; cl01221 983545011837 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 983545011838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545011839 dimer interface [polypeptide binding]; other site 983545011840 phosphorylation site [posttranslational modification] 983545011841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545011842 ATP binding site [chemical binding]; other site 983545011843 Mg2+ binding site [ion binding]; other site 983545011844 G-X-G motif; other site 983545011845 Response regulator receiver domain; Region: Response_reg; pfam00072 983545011846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545011847 active site 983545011848 phosphorylation site [posttranslational modification] 983545011849 intermolecular recognition site; other site 983545011850 dimerization interface [polypeptide binding]; other site 983545011851 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 983545011852 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 983545011853 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 983545011854 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 983545011855 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 983545011856 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 983545011857 alpha subunit interaction interface [polypeptide binding]; other site 983545011858 Walker A motif; other site 983545011859 ATP binding site [chemical binding]; other site 983545011860 Walker B motif; other site 983545011861 inhibitor binding site; inhibition site 983545011862 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 983545011863 ATP synthase; Region: ATP-synt; cl00365 983545011864 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 983545011865 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 983545011866 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 983545011867 beta subunit interaction interface [polypeptide binding]; other site 983545011868 Walker A motif; other site 983545011869 ATP binding site [chemical binding]; other site 983545011870 Walker B motif; other site 983545011871 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 983545011872 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 983545011873 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 983545011874 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 983545011875 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 983545011876 ATP synthase subunit C; Region: ATP-synt_C; cl00466 983545011877 ATP synthase A chain; Region: ATP-synt_A; cl00413 983545011878 ATP synthase I chain; Region: ATP_synt_I; cl09170 983545011879 ParB-like partition proteins; Region: parB_part; TIGR00180 983545011880 ParB-like nuclease domain; Region: ParBc; cl02129 983545011881 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 983545011882 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545011883 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 983545011884 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 983545011885 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 983545011886 hypothetical protein; Validated; Region: PRK08116 983545011887 Phd_YefM; Region: PhdYeFM; cl09153 983545011888 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 983545011889 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 983545011890 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 983545011891 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 983545011892 G1 box; other site 983545011893 GTP/Mg2+ binding site [chemical binding]; other site 983545011894 Switch I region; other site 983545011895 G2 box; other site 983545011896 Switch II region; other site 983545011897 G3 box; other site 983545011898 G4 box; other site 983545011899 G5 box; other site 983545011900 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 983545011901 Protein of unknown function (DUF520); Region: DUF520; cl00723 983545011902 membrane protein insertase; Provisional; Region: PRK01318 983545011903 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 983545011904 Domain of unknown function DUF37; Region: DUF37; cl00506 983545011905 Ribonuclease P; Region: Ribonuclease_P; cl00457 983545011906 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 983545011907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545011908 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 983545011909 Ligand Binding Site [chemical binding]; other site 983545011910 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 983545011911 MPN+ (JAMM) motif; other site 983545011912 Zinc-binding site [ion binding]; other site 983545011913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545011914 cofactor binding site; other site 983545011915 DNA binding site [nucleotide binding] 983545011916 substrate interaction site [chemical binding]; other site 983545011917 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 983545011918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545011919 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 983545011920 Active Sites [active] 983545011921 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 983545011922 Catalytic site [active] 983545011923 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 983545011924 nucleoid-associated protein NdpA; Validated; Region: PRK00378 983545011925 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 983545011926 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 983545011927 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 983545011928 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 983545011929 Y-family of DNA polymerases; Region: PolY; cl12025 983545011930 DNA binding site [nucleotide binding] 983545011931 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545011932 DNA binding site [nucleotide binding] 983545011933 active site 983545011934 Int/Topo IB signature motif; other site 983545011935 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 983545011936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545011937 Walker A motif; other site 983545011938 ATP binding site [chemical binding]; other site 983545011939 Walker B motif; other site 983545011940 StbA protein; Region: StbA; pfam06406 983545011941 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545011942 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 983545011943 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 983545011944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 983545011945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 983545011946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 983545011947 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 983545011948 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545011949 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 983545011950 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 983545011951 AAA-like domain; Region: AAA_10; pfam12846 983545011952 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545011953 DNA binding site [nucleotide binding] 983545011954 Int/Topo IB signature motif; other site 983545011955 active site 983545011956 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 983545011957 active site 2 [active] 983545011958 active site 1 [active] 983545011959 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 983545011960 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 983545011961 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 983545011962 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 983545011963 DNA binding site [nucleotide binding] 983545011964 Int/Topo IB signature motif; other site 983545011965 active site 983545011966 Putative transposase; Region: Y2_Tnp; pfam04986 983545011967 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 983545011968 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 983545011969 inhibitor binding site; inhibition site 983545011970 catalytic motif [active] 983545011971 Catalytic residue [active] 983545011972 Active site flap [active] 983545011973 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 983545011974 IHF dimer interface [polypeptide binding]; other site 983545011975 IHF - DNA interface [nucleotide binding]; other site 983545011976 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 983545011977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 983545011978 putative active site [active] 983545011979 heme pocket [chemical binding]; other site 983545011980 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545011981 metal binding site [ion binding]; metal-binding site 983545011982 active site 983545011983 I-site; other site 983545011984 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 983545011985 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 983545011986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545011987 NAD(P) binding site [chemical binding]; other site 983545011988 active site 983545011989 Vitamin K epoxide reductase family; Region: VKOR; cl01729 983545011990 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 983545011991 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 983545011992 DNA binding residues [nucleotide binding] 983545011993 putative mercuric reductase; Provisional; Region: PRK13748 983545011994 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545011995 metal-binding site [ion binding] 983545011996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545011997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 983545011998 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 983545011999 MerC mercury resistance protein; Region: MerC; cl03934 983545012000 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545012001 metal-binding site [ion binding] 983545012002 MerT mercuric transport protein; Region: MerT; cl03578 983545012003 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 983545012004 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 983545012005 DNA binding residues [nucleotide binding] 983545012006 dimer interface [polypeptide binding]; other site 983545012007 mercury binding site [ion binding]; other site 983545012008 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 983545012009 DNA binding site [nucleotide binding] 983545012010 dimer interface [polypeptide binding]; other site 983545012011 Phage integrase family; Region: Phage_integrase; pfam00589 983545012012 Int/Topo IB signature motif; other site 983545012013 active site 983545012014 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 983545012015 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 983545012016 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 983545012017 active site 983545012018 dimer interface [polypeptide binding]; other site 983545012019 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 983545012020 Ligand Binding Site [chemical binding]; other site 983545012021 Molecular Tunnel; other site 983545012022 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 983545012023 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 983545012024 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 983545012025 carboxyltransferase (CT) interaction site; other site 983545012026 biotinylation site [posttranslational modification]; other site 983545012027 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 983545012028 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 983545012029 Outer membrane efflux protein; Region: OEP; pfam02321 983545012030 Outer membrane efflux protein; Region: OEP; pfam02321 983545012031 Cation efflux family; Region: Cation_efflux; cl00316 983545012032 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 983545012033 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545012034 Cation efflux family; Region: Cation_efflux; cl00316 983545012035 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545012036 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545012037 DNA binding residues [nucleotide binding] 983545012038 dimer interface [polypeptide binding]; other site 983545012039 putative metal binding site [ion binding]; other site 983545012040 hypothetical protein; Provisional; Region: PRK09272 983545012041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 983545012042 Peptidase family M48; Region: Peptidase_M48; cl12018 983545012043 Outer membrane efflux protein; Region: OEP; pfam02321 983545012044 Outer membrane efflux protein; Region: OEP; pfam02321 983545012045 macrolide transporter subunit MacA; Provisional; Region: PRK11578 983545012046 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 983545012047 E3 interaction surface; other site 983545012048 lipoyl attachment site [posttranslational modification]; other site 983545012049 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 983545012050 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 983545012051 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 983545012052 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545012053 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 983545012054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545012055 DNA binding site [nucleotide binding] 983545012056 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545012057 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 983545012058 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 983545012059 translocation protein TolB; Provisional; Region: tolB; PRK04792 983545012060 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 983545012061 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+...; Region: NADH_quinone_reductase; cd06188 983545012062 FAD binding pocket [chemical binding]; other site 983545012063 FAD binding motif [chemical binding]; other site 983545012064 phosphate binding motif [ion binding]; other site 983545012065 beta-alpha-beta structure motif; other site 983545012066 NAD binding pocket [chemical binding]; other site 983545012067 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 983545012068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545012069 active site 983545012070 phosphorylation site [posttranslational modification] 983545012071 intermolecular recognition site; other site 983545012072 dimerization interface [polypeptide binding]; other site 983545012073 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545012074 DNA binding site [nucleotide binding] 983545012075 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 983545012076 Multicopper oxidase; Region: Cu-oxidase; cl14658 983545012077 Multicopper oxidase; Region: Cu-oxidase; cl14658 983545012078 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 983545012079 Multicopper oxidase; Region: Cu-oxidase; cl14658 983545012080 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 983545012081 Copper resistance protein CopC; Region: CopC; cl01012 983545012082 Copper resistance protein D; Region: CopD; cl00563 983545012083 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 983545012084 Domain of unknown function (DUF305); Region: DUF305; pfam03713 983545012085 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545012086 heavy metal efflux pump (cobalt-zinc-cadmium); Region: 2A0601; TIGR00914 983545012087 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 983545012088 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 983545012089 carboxyltransferase (CT) interaction site; other site 983545012090 biotinylation site [posttranslational modification]; other site 983545012091 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 983545012092 Outer membrane efflux protein; Region: OEP; pfam02321 983545012093 Outer membrane efflux protein; Region: OEP; pfam02321 983545012094 Cation efflux family; Region: Cation_efflux; cl00316 983545012095 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 983545012096 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 983545012097 Cation efflux family; Region: Cation_efflux; cl00316 983545012098 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 983545012099 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 983545012100 DNA binding residues [nucleotide binding] 983545012101 dimer interface [polypeptide binding]; other site 983545012102 putative metal binding site [ion binding]; other site 983545012103 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 983545012104 Ligand binding site [chemical binding]; other site 983545012105 Putative Catalytic site [active] 983545012106 DXD motif; other site 983545012107 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 983545012108 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 983545012109 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 983545012110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545012111 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 983545012112 active site residue [active] 983545012113 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 983545012114 active site residue [active] 983545012115 YeeE/YedE family (DUF395); Region: DUF395; cl01018 983545012116 sensor protein QseC; Provisional; Region: PRK10337 983545012117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545012118 dimer interface [polypeptide binding]; other site 983545012119 phosphorylation site [posttranslational modification] 983545012120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012121 ATP binding site [chemical binding]; other site 983545012122 Mg2+ binding site [ion binding]; other site 983545012123 G-X-G motif; other site 983545012124 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545012125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545012126 active site 983545012127 phosphorylation site [posttranslational modification] 983545012128 intermolecular recognition site; other site 983545012129 dimerization interface [polypeptide binding]; other site 983545012130 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545012131 DNA binding site [nucleotide binding] 983545012132 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 983545012133 catalytic residues [active] 983545012134 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 983545012135 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 983545012136 dimerization domain [polypeptide binding]; other site 983545012137 dimer interface [polypeptide binding]; other site 983545012138 catalytic residues [active] 983545012139 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 983545012140 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 983545012141 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 983545012142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 983545012143 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 983545012144 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 983545012145 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 983545012146 Multicopper oxidase; Region: Cu-oxidase; cl14658 983545012147 Multicopper oxidase; Region: Cu-oxidase; cl14658 983545012148 Multicopper oxidase; Region: Cu-oxidase; cl14658 983545012149 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 983545012150 Domain of unknown function (DUF305); Region: DUF305; pfam03713 983545012151 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 983545012152 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 983545012153 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 983545012154 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 983545012155 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 983545012156 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 983545012157 metal-binding site [ion binding] 983545012158 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 983545012159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 983545012160 Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787 983545012161 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 983545012162 DNA binding residues [nucleotide binding] 983545012163 dimer interface [polypeptide binding]; other site 983545012164 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 983545012165 dimerization interface [polypeptide binding]; other site 983545012166 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 983545012167 ATP binding site [chemical binding]; other site 983545012168 Acylphosphatase; Region: Acylphosphatase; cl00551 983545012169 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 983545012170 HypF finger; Region: zf-HYPF; pfam07503 983545012171 HypF finger; Region: zf-HYPF; pfam07503 983545012172 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 983545012173 Hydrogenase formation hypA family; Region: HypD; cl12072 983545012174 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 983545012175 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 983545012176 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 983545012177 HupF/HypC family; Region: HupF_HypC; cl00394 983545012178 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 983545012179 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 983545012180 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 983545012181 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 983545012182 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase...; Region: H2MP_MemB-H2up; cd06062 983545012183 putative substrate-binding site; other site 983545012184 nickel binding site [ion binding]; other site 983545012185 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 983545012186 heme-binding residues [chemical binding]; other site 983545012187 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 983545012188 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 983545012189 FAD binding pocket [chemical binding]; other site 983545012190 FAD binding motif [chemical binding]; other site 983545012191 phosphate binding motif [ion binding]; other site 983545012192 beta-alpha-beta structure motif; other site 983545012193 NAD binding pocket [chemical binding]; other site 983545012194 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 983545012195 catalytic loop [active] 983545012196 iron binding site [ion binding]; other site 983545012197 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 983545012198 Cytochrome c; Region: Cytochrom_C; cl11414 983545012199 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 983545012200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 983545012201 NAD(P) binding site [chemical binding]; other site 983545012202 active site 983545012203 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 983545012204 FAD binding domain; Region: FAD_binding_4; pfam01565 983545012205 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 983545012206 Copper resistance protein D; Region: CopD; cl00563 983545012207 Copper resistance protein CopC; Region: CopC; cl01012 983545012208 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 983545012209 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 983545012210 FAD binding pocket [chemical binding]; other site 983545012211 conserved FAD binding motif [chemical binding]; other site 983545012212 phosphate binding motif [ion binding]; other site 983545012213 beta-alpha-beta structure motif; other site 983545012214 NAD binding pocket [chemical binding]; other site 983545012215 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 983545012216 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 983545012217 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 983545012218 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 983545012219 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 983545012220 Outer membrane efflux protein; Region: OEP; pfam02321 983545012221 Outer membrane efflux protein; Region: OEP; pfam02321 983545012222 Protein of unknown function, DUF; Region: DUF411; cl01142 983545012223 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 983545012224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545012225 active site 983545012226 phosphorylation site [posttranslational modification] 983545012227 intermolecular recognition site; other site 983545012228 dimerization interface [polypeptide binding]; other site 983545012229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545012230 DNA binding site [nucleotide binding] 983545012231 sensor kinase CusS; Provisional; Region: PRK09835 983545012232 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 983545012233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545012234 dimer interface [polypeptide binding]; other site 983545012235 phosphorylation site [posttranslational modification] 983545012236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012237 ATP binding site [chemical binding]; other site 983545012238 Mg2+ binding site [ion binding]; other site 983545012239 G-X-G motif; other site 983545012240 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 983545012241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 983545012242 active site 983545012243 phosphorylation site [posttranslational modification] 983545012244 intermolecular recognition site; other site 983545012245 dimerization interface [polypeptide binding]; other site 983545012246 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 983545012247 DNA binding site [nucleotide binding] 983545012248 sensor protein QseC; Provisional; Region: PRK10337 983545012249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 983545012250 dimer interface [polypeptide binding]; other site 983545012251 phosphorylation site [posttranslational modification] 983545012252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 983545012253 ATP binding site [chemical binding]; other site 983545012254 Mg2+ binding site [ion binding]; other site 983545012255 G-X-G motif; other site 983545012256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 983545012257 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 983545012258 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 983545012259 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 983545012260 Integrase core domain; Region: rve; cl01316 983545012261 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 983545012262 active site 983545012263 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 983545012264 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545012265 Sulfatase; Region: Sulfatase; cl10460 983545012266 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 983545012267 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 983545012268 putative metal dependent hydrolase; Provisional; Region: PRK11598 983545012269 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 983545012270 Sulfatase; Region: Sulfatase; cl10460 983545012271 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 983545012272 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 983545012273 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 983545012274 Sulfatase; Region: Sulfatase; cl10460 983545012275 putative transposase OrfB; Reviewed; Region: PHA02517 983545012276 Integrase core domain; Region: rve; cl01316 983545012277 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 983545012278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 983545012279 HipA N-terminal domain; Region: couple_hipA; TIGR03071 983545012280 HipA-like N-terminal domain; Region: HipA_N; pfam07805 983545012281 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545012282 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 983545012283 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 983545012284 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545012285 Calx-beta domain; Region: Calx-beta; cl02522 983545012286 Calx-beta domain; Region: Calx-beta; cl02522 983545012287 Calx-beta domain; Region: Calx-beta; cl02522 983545012288 Calx-beta domain; Region: Calx-beta; cl02522 983545012289 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 983545012290 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 983545012291 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 983545012292 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 983545012293 Protein of unknown function (DUF993); Region: DUF993; pfam06187 983545012294 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 983545012295 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 983545012296 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 983545012297 Walker A motif; other site 983545012298 ATP binding site [chemical binding]; other site 983545012299 Walker B motif; other site 983545012300 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 983545012301 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 983545012302 Putative exonuclease, RdgC; Region: RdgC; cl01122 983545012303 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 983545012304 Staphylococcal nuclease homologues; Region: SNc; smart00318 983545012305 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 983545012306 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 983545012307 metal binding site [ion binding]; metal-binding site 983545012308 active site 983545012309 I-site; other site 983545012310 HipA-like C-terminal domain; Region: HipA_C; pfam07804 983545012311 probable DNA repair protein; Region: TIGR03623 983545012312 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 983545012313 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 983545012314 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 983545012315 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545012316 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 983545012317 UvrD/REP helicase; Region: UvrD-helicase; cl14126 983545012318 plasmid-partitioning protein; Provisional; Region: PRK13698 983545012319 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 983545012320 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 983545012321 P-loop; other site 983545012322 Magnesium ion binding site [ion binding]; other site 983545012323 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 983545012324 ParB-like nuclease domain; Region: ParBc; cl02129 983545012325 PRTRC system protein B; Region: PRTRC_B; TIGR03737 983545012326 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 983545012327 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 983545012328 ATP binding site [chemical binding]; other site 983545012329 substrate interface [chemical binding]; other site