-- dump date 20140619_102909 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1129794000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1129794000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1129794000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794000004 Walker A motif; other site 1129794000005 ATP binding site [chemical binding]; other site 1129794000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1129794000007 Walker B motif; other site 1129794000008 arginine finger; other site 1129794000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1129794000010 DnaA box-binding interface [nucleotide binding]; other site 1129794000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1129794000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1129794000013 putative DNA binding surface [nucleotide binding]; other site 1129794000014 dimer interface [polypeptide binding]; other site 1129794000015 beta-clamp/clamp loader binding surface; other site 1129794000016 beta-clamp/translesion DNA polymerase binding surface; other site 1129794000017 recombination protein F; Reviewed; Region: recF; PRK00064 1129794000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794000019 Walker A/P-loop; other site 1129794000020 ATP binding site [chemical binding]; other site 1129794000021 Q-loop/lid; other site 1129794000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794000023 ABC transporter signature motif; other site 1129794000024 Walker B; other site 1129794000025 D-loop; other site 1129794000026 H-loop/switch region; other site 1129794000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1129794000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794000029 Mg2+ binding site [ion binding]; other site 1129794000030 G-X-G motif; other site 1129794000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1129794000032 anchoring element; other site 1129794000033 dimer interface [polypeptide binding]; other site 1129794000034 ATP binding site [chemical binding]; other site 1129794000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1129794000036 active site 1129794000037 putative metal-binding site [ion binding]; other site 1129794000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1129794000039 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1129794000040 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1129794000041 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1129794000042 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1129794000043 dimer interface [polypeptide binding]; other site 1129794000044 motif 1; other site 1129794000045 active site 1129794000046 motif 2; other site 1129794000047 motif 3; other site 1129794000048 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 1129794000049 Der GTPase activator; Provisional; Region: PRK05244 1129794000050 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1129794000051 Cytochrome c; Region: Cytochrom_C; cl11414 1129794000052 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1129794000053 G1 box; other site 1129794000054 GTP/Mg2+ binding site [chemical binding]; other site 1129794000055 Switch I region; other site 1129794000056 G2 box; other site 1129794000057 G3 box; other site 1129794000058 Switch II region; other site 1129794000059 G4 box; other site 1129794000060 G5 box; other site 1129794000061 DNA polymerase I; Provisional; Region: PRK05755 1129794000062 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1129794000063 active site 1129794000064 metal binding site 1 [ion binding]; metal-binding site 1129794000065 putative 5' ssDNA interaction site; other site 1129794000066 metal binding site 3; metal-binding site 1129794000067 metal binding site 2 [ion binding]; metal-binding site 1129794000068 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1129794000069 putative DNA binding site [nucleotide binding]; other site 1129794000070 putative metal binding site [ion binding]; other site 1129794000071 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1129794000072 active site 1129794000073 catalytic site [active] 1129794000074 substrate binding site [chemical binding]; other site 1129794000075 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1129794000076 active site 1129794000077 DNA binding site [nucleotide binding] 1129794000078 catalytic site [active] 1129794000079 Cation transport protein; Region: TrkH; cl17365 1129794000080 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1129794000081 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 1129794000082 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 1129794000083 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1129794000084 TrkA-N domain; Region: TrkA_N; pfam02254 1129794000085 TrkA-C domain; Region: TrkA_C; pfam02080 1129794000086 TrkA-N domain; Region: TrkA_N; pfam02254 1129794000087 TrkA-C domain; Region: TrkA_C; pfam02080 1129794000088 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1129794000089 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1129794000090 putative RNA binding site [nucleotide binding]; other site 1129794000091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794000092 S-adenosylmethionine binding site [chemical binding]; other site 1129794000093 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1129794000094 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1129794000095 putative active site [active] 1129794000096 substrate binding site [chemical binding]; other site 1129794000097 putative cosubstrate binding site; other site 1129794000098 catalytic site [active] 1129794000099 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1129794000100 substrate binding site [chemical binding]; other site 1129794000101 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1129794000102 active site 1129794000103 catalytic residues [active] 1129794000104 metal binding site [ion binding]; metal-binding site 1129794000105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1129794000106 hypothetical protein; Provisional; Region: PRK10736 1129794000107 DNA protecting protein DprA; Region: dprA; TIGR00732 1129794000108 hypothetical protein; Validated; Region: PRK03430 1129794000109 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1129794000110 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1129794000111 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1129794000112 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1129794000113 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1129794000114 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1129794000115 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1129794000116 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1129794000117 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1129794000118 shikimate binding site; other site 1129794000119 NAD(P) binding site [chemical binding]; other site 1129794000120 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1129794000121 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1129794000122 trimer interface [polypeptide binding]; other site 1129794000123 putative metal binding site [ion binding]; other site 1129794000124 Winged helix-turn helix; Region: HTH_29; pfam13551 1129794000125 EVE domain; Region: EVE; cl00728 1129794000126 Integrase core domain; Region: rve_3; pfam13683 1129794000127 Integrase core domain; Region: rve; pfam00665 1129794000128 Transposase; Region: HTH_Tnp_1; cl17663 1129794000129 ketol-acid reductoisomerase; Validated; Region: PRK05225 1129794000130 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1129794000131 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1129794000132 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1129794000133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794000134 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1129794000135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794000136 dimerization interface [polypeptide binding]; other site 1129794000137 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1129794000138 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1129794000139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794000140 Walker A motif; other site 1129794000141 ATP binding site [chemical binding]; other site 1129794000142 Walker B motif; other site 1129794000143 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1129794000144 Predicted membrane protein [Function unknown]; Region: COG2860 1129794000145 UPF0126 domain; Region: UPF0126; pfam03458 1129794000146 UPF0126 domain; Region: UPF0126; pfam03458 1129794000147 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1129794000148 tetramer interface [polypeptide binding]; other site 1129794000149 threonine dehydratase; Reviewed; Region: PRK09224 1129794000150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794000151 catalytic residue [active] 1129794000152 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1129794000153 putative Ile/Val binding site [chemical binding]; other site 1129794000154 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1129794000155 putative Ile/Val binding site [chemical binding]; other site 1129794000156 glutaminase; Provisional; Region: PRK00971 1129794000157 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1129794000158 Leucine rich repeat; Region: LRR_8; pfam13855 1129794000159 Leucine rich repeat; Region: LRR_8; pfam13855 1129794000160 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1129794000161 active site 1129794000162 ATP binding site [chemical binding]; other site 1129794000163 substrate binding site [chemical binding]; other site 1129794000164 activation loop (A-loop); other site 1129794000165 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1129794000166 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 1129794000167 PA/protease or protease-like domain interface [polypeptide binding]; other site 1129794000168 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 1129794000169 Peptidase family M28; Region: Peptidase_M28; pfam04389 1129794000170 metal binding site [ion binding]; metal-binding site 1129794000171 division inhibitor protein; Provisional; Region: slmA; PRK09480 1129794000172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794000173 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1129794000174 Flavoprotein; Region: Flavoprotein; pfam02441 1129794000175 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1129794000176 hypothetical protein; Reviewed; Region: PRK00024 1129794000177 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1129794000178 MPN+ (JAMM) motif; other site 1129794000179 Zinc-binding site [ion binding]; other site 1129794000180 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 1129794000181 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1129794000182 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1129794000183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794000184 putative ADP-binding pocket [chemical binding]; other site 1129794000185 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1129794000186 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1129794000187 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1129794000188 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1129794000189 DNA binding site [nucleotide binding] 1129794000190 catalytic residue [active] 1129794000191 H2TH interface [polypeptide binding]; other site 1129794000192 putative catalytic residues [active] 1129794000193 turnover-facilitating residue; other site 1129794000194 intercalation triad [nucleotide binding]; other site 1129794000195 8OG recognition residue [nucleotide binding]; other site 1129794000196 putative reading head residues; other site 1129794000197 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1129794000198 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1129794000199 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1129794000200 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1129794000201 active site 1129794000202 (T/H)XGH motif; other site 1129794000203 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1129794000204 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1129794000205 active site 1129794000206 KMSKS motif; other site 1129794000207 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 1129794000208 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 1129794000209 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1129794000210 active site 1129794000211 ATP binding site [chemical binding]; other site 1129794000212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794000213 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1129794000214 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1129794000215 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1129794000216 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1129794000217 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794000218 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794000219 metal binding site [ion binding]; metal-binding site 1129794000220 active site 1129794000221 I-site; other site 1129794000222 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794000223 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1129794000224 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1129794000225 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1129794000226 Cupin domain; Region: Cupin_2; pfam07883 1129794000227 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1129794000228 classical (c) SDRs; Region: SDR_c; cd05233 1129794000229 NAD(P) binding site [chemical binding]; other site 1129794000230 active site 1129794000231 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1129794000232 histidinol dehydrogenase; Region: hisD; TIGR00069 1129794000233 NAD binding site [chemical binding]; other site 1129794000234 dimerization interface [polypeptide binding]; other site 1129794000235 product binding site; other site 1129794000236 substrate binding site [chemical binding]; other site 1129794000237 zinc binding site [ion binding]; other site 1129794000238 catalytic residues [active] 1129794000239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1129794000240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1129794000241 DNA binding site [nucleotide binding] 1129794000242 domain linker motif; other site 1129794000243 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1129794000244 putative dimerization interface [polypeptide binding]; other site 1129794000245 putative ligand binding site [chemical binding]; other site 1129794000246 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794000247 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1129794000248 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1129794000249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000250 TPR repeat; Region: TPR_11; pfam13414 1129794000251 binding surface 1129794000252 TPR motif; other site 1129794000253 TPR repeat; Region: TPR_11; pfam13414 1129794000254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000255 binding surface 1129794000256 TPR motif; other site 1129794000257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000258 TPR motif; other site 1129794000259 binding surface 1129794000260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1129794000261 binding surface 1129794000262 TPR motif; other site 1129794000263 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1129794000264 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794000265 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794000266 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1129794000267 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1129794000268 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1129794000269 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1129794000270 nucleophilic elbow; other site 1129794000271 catalytic triad; other site 1129794000272 SnoaL-like domain; Region: SnoaL_2; pfam12680 1129794000273 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 1129794000274 Na binding site [ion binding]; other site 1129794000275 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1129794000276 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1129794000277 SnoaL-like domain; Region: SnoaL_2; pfam12680 1129794000278 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1129794000279 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1129794000280 substrate-cofactor binding pocket; other site 1129794000281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794000282 catalytic residue [active] 1129794000283 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1129794000284 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1129794000285 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1129794000286 NAD(P) binding site [chemical binding]; other site 1129794000287 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1129794000288 active site residue [active] 1129794000289 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 1129794000290 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1129794000291 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1129794000292 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 1129794000293 Chorismate lyase; Region: Chor_lyase; cl01230 1129794000294 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1129794000295 UbiA prenyltransferase family; Region: UbiA; pfam01040 1129794000296 Membrane fusogenic activity; Region: BMFP; pfam04380 1129794000297 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1129794000298 Part of AAA domain; Region: AAA_19; pfam13245 1129794000299 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1129794000300 Family description; Region: UvrD_C_2; pfam13538 1129794000301 GAF domain; Region: GAF_2; pfam13185 1129794000302 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1129794000303 GAF domain; Region: GAF; pfam01590 1129794000304 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794000305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794000306 metal binding site [ion binding]; metal-binding site 1129794000307 active site 1129794000308 I-site; other site 1129794000309 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794000310 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1129794000311 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1129794000312 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1129794000313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794000314 active site 1129794000315 phosphorylation site [posttranslational modification] 1129794000316 intermolecular recognition site; other site 1129794000317 dimerization interface [polypeptide binding]; other site 1129794000318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794000319 dimer interface [polypeptide binding]; other site 1129794000320 phosphorylation site [posttranslational modification] 1129794000321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794000322 ATP binding site [chemical binding]; other site 1129794000323 Mg2+ binding site [ion binding]; other site 1129794000324 G-X-G motif; other site 1129794000325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794000326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794000327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1129794000328 oxidative damage protection protein; Provisional; Region: PRK05408 1129794000329 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1129794000330 DNA binding and oxoG recognition site [nucleotide binding] 1129794000331 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1129794000332 endonuclease III; Region: ENDO3c; smart00478 1129794000333 minor groove reading motif; other site 1129794000334 helix-hairpin-helix signature motif; other site 1129794000335 substrate binding pocket [chemical binding]; other site 1129794000336 active site 1129794000337 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1129794000338 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794000339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794000340 S-adenosylmethionine binding site [chemical binding]; other site 1129794000341 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1129794000342 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1129794000343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794000344 S-adenosylmethionine binding site [chemical binding]; other site 1129794000345 glycogen synthase; Provisional; Region: glgA; PRK00654 1129794000346 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1129794000347 ADP-binding pocket [chemical binding]; other site 1129794000348 homodimer interface [polypeptide binding]; other site 1129794000349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794000350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1129794000351 dimerization interface [polypeptide binding]; other site 1129794000352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794000353 dimer interface [polypeptide binding]; other site 1129794000354 phosphorylation site [posttranslational modification] 1129794000355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794000356 ATP binding site [chemical binding]; other site 1129794000357 Mg2+ binding site [ion binding]; other site 1129794000358 G-X-G motif; other site 1129794000359 two-component response regulator; Provisional; Region: PRK11173 1129794000360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794000361 active site 1129794000362 phosphorylation site [posttranslational modification] 1129794000363 intermolecular recognition site; other site 1129794000364 dimerization interface [polypeptide binding]; other site 1129794000365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794000366 DNA binding site [nucleotide binding] 1129794000367 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1129794000368 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794000369 catalytic residues [active] 1129794000370 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 1129794000371 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 1129794000372 ApbE family; Region: ApbE; pfam02424 1129794000373 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1129794000374 lipase chaperone; Provisional; Region: PRK01294 1129794000375 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 1129794000376 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1129794000377 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1129794000378 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1129794000379 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1129794000380 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1129794000381 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1129794000382 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1129794000383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794000384 dimer interface [polypeptide binding]; other site 1129794000385 phosphorylation site [posttranslational modification] 1129794000386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794000387 ATP binding site [chemical binding]; other site 1129794000388 Mg2+ binding site [ion binding]; other site 1129794000389 G-X-G motif; other site 1129794000390 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1129794000391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794000392 active site 1129794000393 phosphorylation site [posttranslational modification] 1129794000394 intermolecular recognition site; other site 1129794000395 dimerization interface [polypeptide binding]; other site 1129794000396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794000397 DNA binding site [nucleotide binding] 1129794000398 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1129794000399 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1129794000400 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1129794000401 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1129794000402 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1129794000403 DsbD alpha interface [polypeptide binding]; other site 1129794000404 catalytic residues [active] 1129794000405 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1129794000406 Peptidase family M23; Region: Peptidase_M23; pfam01551 1129794000407 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1129794000408 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794000409 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1129794000410 putative transposase OrfB; Reviewed; Region: PHA02517 1129794000411 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1129794000412 active site 1129794000413 Protein of unknown function, DUF479; Region: DUF479; cl01203 1129794000414 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1129794000415 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1129794000416 trimer interface [polypeptide binding]; other site 1129794000417 active site 1129794000418 dimer interface [polypeptide binding]; other site 1129794000419 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1129794000420 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1129794000421 carboxyltransferase (CT) interaction site; other site 1129794000422 biotinylation site [posttranslational modification]; other site 1129794000423 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1129794000424 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1129794000425 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794000426 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1129794000427 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1129794000428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794000429 S-adenosylmethionine binding site [chemical binding]; other site 1129794000430 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1129794000431 ATP-grasp domain; Region: ATP-grasp; pfam02222 1129794000432 AIR carboxylase; Region: AIRC; pfam00731 1129794000433 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1129794000434 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 1129794000435 metal binding site [ion binding]; metal-binding site 1129794000436 putative dimer interface [polypeptide binding]; other site 1129794000437 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1129794000438 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1129794000439 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1129794000440 RNA binding site [nucleotide binding]; other site 1129794000441 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1129794000442 multimer interface [polypeptide binding]; other site 1129794000443 Walker A motif; other site 1129794000444 ATP binding site [chemical binding]; other site 1129794000445 Walker B motif; other site 1129794000446 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1129794000447 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794000448 catalytic residues [active] 1129794000449 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1129794000450 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794000451 ATP binding site [chemical binding]; other site 1129794000452 Mg++ binding site [ion binding]; other site 1129794000453 motif III; other site 1129794000454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794000455 nucleotide binding region [chemical binding]; other site 1129794000456 ATP-binding site [chemical binding]; other site 1129794000457 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1129794000458 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1129794000459 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1129794000460 dimer interface [polypeptide binding]; other site 1129794000461 allosteric magnesium binding site [ion binding]; other site 1129794000462 active site 1129794000463 aspartate-rich active site metal binding site; other site 1129794000464 Schiff base residues; other site 1129794000465 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1129794000466 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1129794000467 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794000468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794000469 metal binding site [ion binding]; metal-binding site 1129794000470 active site 1129794000471 I-site; other site 1129794000472 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1129794000473 active site 1129794000474 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1129794000475 sec-independent translocase; Provisional; Region: PRK01770 1129794000476 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1129794000477 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1129794000478 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1129794000479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1129794000480 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1129794000481 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1129794000482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794000483 S-adenosylmethionine binding site [chemical binding]; other site 1129794000484 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1129794000485 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 1129794000486 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1129794000487 oligopeptidase A; Provisional; Region: PRK10911 1129794000488 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1129794000489 active site 1129794000490 Zn binding site [ion binding]; other site 1129794000491 glutathione reductase; Validated; Region: PRK06116 1129794000492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794000493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1129794000494 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1129794000495 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1129794000496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794000497 putative substrate translocation pore; other site 1129794000498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794000499 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1129794000500 FecR protein; Region: FecR; pfam04773 1129794000501 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1129794000502 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794000503 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794000504 DNA binding residues [nucleotide binding] 1129794000505 Secretin and TonB N terminus short domain; Region: STN; smart00965 1129794000506 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1129794000507 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794000508 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794000509 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794000510 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794000511 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1129794000512 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794000513 SapC; Region: SapC; pfam07277 1129794000514 Cupin-like domain; Region: Cupin_8; pfam13621 1129794000515 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1129794000516 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1129794000517 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1129794000518 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1129794000519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794000520 Coenzyme A binding pocket [chemical binding]; other site 1129794000521 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1129794000522 Pirin; Region: Pirin; pfam02678 1129794000523 Pirin-related protein [General function prediction only]; Region: COG1741 1129794000524 Pirin-related protein [General function prediction only]; Region: COG1741 1129794000525 Pirin; Region: Pirin; pfam02678 1129794000526 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1129794000527 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1129794000528 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 1129794000529 putative FMN binding site [chemical binding]; other site 1129794000530 putative dimer interface [polypeptide binding]; other site 1129794000531 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1129794000532 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794000533 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794000534 ABC transporter; Region: ABC_tran_2; pfam12848 1129794000535 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794000536 Penicillin amidase; Region: Penicil_amidase; pfam01804 1129794000537 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1129794000538 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1129794000539 active site 1129794000540 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1129794000541 formimidoylglutamase; Provisional; Region: PRK13775 1129794000542 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1129794000543 putative active site [active] 1129794000544 putative metal binding site [ion binding]; other site 1129794000545 imidazolonepropionase; Validated; Region: PRK09356 1129794000546 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1129794000547 active site 1129794000548 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1129794000549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794000550 DNA-binding site [nucleotide binding]; DNA binding site 1129794000551 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1129794000552 urocanate hydratase; Provisional; Region: PRK05414 1129794000553 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1129794000554 active sites [active] 1129794000555 tetramer interface [polypeptide binding]; other site 1129794000556 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 1129794000557 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1129794000558 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1129794000559 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1129794000560 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1129794000561 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1129794000562 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1129794000563 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12507 1129794000564 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1129794000565 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1129794000566 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1129794000567 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1129794000568 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1129794000569 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 1129794000570 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1129794000571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794000572 Walker A motif; other site 1129794000573 ATP binding site [chemical binding]; other site 1129794000574 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1129794000575 Walker B motif; other site 1129794000576 arginine finger; other site 1129794000577 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1129794000578 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1129794000579 active site 1129794000580 HslU subunit interaction site [polypeptide binding]; other site 1129794000581 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1129794000582 Sporulation related domain; Region: SPOR; pfam05036 1129794000583 primosome assembly protein PriA; Validated; Region: PRK05580 1129794000584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794000585 ATP binding site [chemical binding]; other site 1129794000586 putative Mg++ binding site [ion binding]; other site 1129794000587 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1129794000588 ATP-binding site [chemical binding]; other site 1129794000589 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1129794000590 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1129794000591 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1129794000592 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1129794000593 putative NAD(P) binding site [chemical binding]; other site 1129794000594 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794000595 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1129794000596 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1129794000597 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1129794000598 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1129794000599 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 1129794000600 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1129794000601 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1129794000602 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1129794000603 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1129794000604 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794000605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794000606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1129794000607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794000608 non-specific DNA binding site [nucleotide binding]; other site 1129794000609 salt bridge; other site 1129794000610 sequence-specific DNA binding site [nucleotide binding]; other site 1129794000611 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1129794000612 heme binding site [chemical binding]; other site 1129794000613 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1129794000614 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1129794000615 amidase; Provisional; Region: PRK08137 1129794000616 Amidase; Region: Amidase; cl11426 1129794000617 Predicted flavoproteins [General function prediction only]; Region: COG2081 1129794000618 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1129794000619 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1129794000620 active site 1129794000621 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1129794000622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794000623 active site 1129794000624 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1129794000625 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794000626 active site 1129794000627 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1129794000628 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794000629 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794000630 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794000631 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794000632 active site 1129794000633 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1129794000634 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1129794000635 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1129794000636 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794000637 catalytic loop [active] 1129794000638 iron binding site [ion binding]; other site 1129794000639 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1129794000640 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1129794000641 [4Fe-4S] binding site [ion binding]; other site 1129794000642 molybdopterin cofactor binding site; other site 1129794000643 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1129794000644 molybdopterin cofactor binding site; other site 1129794000645 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1129794000646 putative dimer interface [polypeptide binding]; other site 1129794000647 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1129794000648 SLBB domain; Region: SLBB; pfam10531 1129794000649 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1129794000650 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1129794000651 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1129794000652 putative dimer interface [polypeptide binding]; other site 1129794000653 [2Fe-2S] cluster binding site [ion binding]; other site 1129794000654 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1129794000655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794000656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1129794000657 dimerization interface [polypeptide binding]; other site 1129794000658 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1129794000659 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1129794000660 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1129794000661 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1129794000662 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1129794000663 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1129794000664 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1129794000665 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794000666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794000667 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794000668 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1129794000669 Integrase core domain; Region: rve; pfam00665 1129794000670 Integrase core domain; Region: rve; pfam00665 1129794000671 Transposase; Region: HTH_Tnp_1; pfam01527 1129794000672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794000673 Nitrate and nitrite sensing; Region: NIT; pfam08376 1129794000674 ANTAR domain; Region: ANTAR; pfam03861 1129794000675 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1129794000676 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1129794000677 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1129794000678 Surface antigen; Region: Bac_surface_Ag; pfam01103 1129794000679 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794000680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794000681 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794000682 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1129794000683 nudix motif; other site 1129794000684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000685 TPR motif; other site 1129794000686 binding surface 1129794000687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794000688 DNA binding site [nucleotide binding] 1129794000689 Predicted integral membrane protein [Function unknown]; Region: COG5616 1129794000690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000691 binding surface 1129794000692 TPR motif; other site 1129794000693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000694 TPR motif; other site 1129794000695 binding surface 1129794000696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000697 binding surface 1129794000698 TPR motif; other site 1129794000699 AMP-binding domain protein; Validated; Region: PRK07529 1129794000700 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794000701 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1129794000702 acyl-activating enzyme (AAE) consensus motif; other site 1129794000703 putative AMP binding site [chemical binding]; other site 1129794000704 putative active site [active] 1129794000705 putative CoA binding site [chemical binding]; other site 1129794000706 acetyl-CoA acetyltransferase; Provisional; Region: PRK08131 1129794000707 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1129794000708 dimer interface [polypeptide binding]; other site 1129794000709 active site 1129794000710 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794000711 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1129794000712 substrate binding site [chemical binding]; other site 1129794000713 oxyanion hole (OAH) forming residues; other site 1129794000714 trimer interface [polypeptide binding]; other site 1129794000715 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1129794000716 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1129794000717 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1129794000718 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1129794000719 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1129794000720 FMN binding site [chemical binding]; other site 1129794000721 substrate binding site [chemical binding]; other site 1129794000722 putative catalytic residue [active] 1129794000723 enoyl-CoA hydratase; Provisional; Region: PRK06688 1129794000724 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794000725 substrate binding site [chemical binding]; other site 1129794000726 oxyanion hole (OAH) forming residues; other site 1129794000727 trimer interface [polypeptide binding]; other site 1129794000728 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1129794000729 CoenzymeA binding site [chemical binding]; other site 1129794000730 subunit interaction site [polypeptide binding]; other site 1129794000731 PHB binding site; other site 1129794000732 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1129794000733 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1129794000734 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1129794000735 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1129794000736 DctM-like transporters; Region: DctM; pfam06808 1129794000737 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1129794000738 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1129794000739 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1129794000740 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1129794000741 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1129794000742 Bacterial transcriptional regulator; Region: IclR; pfam01614 1129794000743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794000744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794000745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1129794000746 dimerization interface [polypeptide binding]; other site 1129794000747 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1129794000748 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1129794000749 FAD binding site [chemical binding]; other site 1129794000750 substrate binding pocket [chemical binding]; other site 1129794000751 catalytic base [active] 1129794000752 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 1129794000753 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1129794000754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794000755 Coenzyme A binding pocket [chemical binding]; other site 1129794000756 Peptidase_C39 like family; Region: DUF3335; pfam11814 1129794000757 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1129794000758 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1129794000759 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794000760 transcriptional regulator HdfR; Provisional; Region: PRK03601 1129794000761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794000762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794000763 dimerization interface [polypeptide binding]; other site 1129794000764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794000765 S-adenosylmethionine binding site [chemical binding]; other site 1129794000766 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1129794000767 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1129794000768 ssDNA binding site; other site 1129794000769 generic binding surface II; other site 1129794000770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794000771 ATP binding site [chemical binding]; other site 1129794000772 putative Mg++ binding site [ion binding]; other site 1129794000773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794000774 nucleotide binding region [chemical binding]; other site 1129794000775 ATP-binding site [chemical binding]; other site 1129794000776 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1129794000777 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794000778 putative catalytic residues [active] 1129794000779 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1129794000780 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1129794000781 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1129794000782 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1129794000783 homotrimer interaction site [polypeptide binding]; other site 1129794000784 putative active site [active] 1129794000785 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1129794000786 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794000787 Zn2+ binding site [ion binding]; other site 1129794000788 Mg2+ binding site [ion binding]; other site 1129794000789 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1129794000790 synthetase active site [active] 1129794000791 NTP binding site [chemical binding]; other site 1129794000792 metal binding site [ion binding]; metal-binding site 1129794000793 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1129794000794 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1129794000795 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1129794000796 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1129794000797 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1129794000798 catalytic site [active] 1129794000799 G-X2-G-X-G-K; other site 1129794000800 iron donor protein CyaY; Region: FeS_CyaY; TIGR03421 1129794000801 putative iron binding site [ion binding]; other site 1129794000802 putative hydrolase; Provisional; Region: PRK11460 1129794000803 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1129794000804 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1129794000805 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1129794000806 transmembrane helices; other site 1129794000807 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1129794000808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1129794000809 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1129794000810 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1129794000811 domain interfaces; other site 1129794000812 active site 1129794000813 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1129794000814 active site 1129794000815 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1129794000816 HemX; Region: HemX; pfam04375 1129794000817 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1129794000818 HemY protein N-terminus; Region: HemY_N; pfam07219 1129794000819 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 1129794000820 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1129794000821 HSP70 interaction site [polypeptide binding]; other site 1129794000822 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1129794000823 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1129794000824 active site 1129794000825 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1129794000826 active site 1129794000827 substrate binding site [chemical binding]; other site 1129794000828 catalytic site [active] 1129794000829 acetyl-CoA synthetase; Provisional; Region: PRK00174 1129794000830 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1129794000831 active site 1129794000832 CoA binding site [chemical binding]; other site 1129794000833 acyl-activating enzyme (AAE) consensus motif; other site 1129794000834 AMP binding site [chemical binding]; other site 1129794000835 acetate binding site [chemical binding]; other site 1129794000836 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1129794000837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794000838 putative substrate translocation pore; other site 1129794000839 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1129794000840 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1129794000841 active site 1129794000842 dimer interface [polypeptide binding]; other site 1129794000843 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1129794000844 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1129794000845 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1129794000846 active site 1129794000847 trimer interface [polypeptide binding]; other site 1129794000848 allosteric site; other site 1129794000849 active site lid [active] 1129794000850 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1129794000851 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1129794000852 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1129794000853 DNA binding site [nucleotide binding] 1129794000854 domain linker motif; other site 1129794000855 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 1129794000856 putative dimerization interface [polypeptide binding]; other site 1129794000857 putative ligand binding site [chemical binding]; other site 1129794000858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794000859 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794000860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794000861 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1129794000862 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1129794000863 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1129794000864 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1129794000865 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1129794000866 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1129794000867 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1129794000868 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794000869 Protein of unknown function (DUF983); Region: DUF983; cl02211 1129794000870 Protein export membrane protein; Region: SecD_SecF; cl14618 1129794000871 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794000872 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794000873 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794000874 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1129794000875 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794000876 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1129794000877 SelR domain; Region: SelR; pfam01641 1129794000878 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1129794000879 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1129794000880 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1129794000881 Cation efflux family; Region: Cation_efflux; cl00316 1129794000882 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1129794000883 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1129794000884 5-oxoprolinase; Region: PLN02666 1129794000885 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1129794000886 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1129794000887 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1129794000888 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1129794000889 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1129794000890 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1129794000891 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1129794000892 FAD binding pocket [chemical binding]; other site 1129794000893 FAD binding motif [chemical binding]; other site 1129794000894 phosphate binding motif [ion binding]; other site 1129794000895 beta-alpha-beta structure motif; other site 1129794000896 NAD binding pocket [chemical binding]; other site 1129794000897 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1129794000898 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794000899 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1129794000900 classical (c) SDRs; Region: SDR_c; cd05233 1129794000901 NAD(P) binding site [chemical binding]; other site 1129794000902 active site 1129794000903 siroheme synthase; Provisional; Region: cysG; PRK10637 1129794000904 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1129794000905 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1129794000906 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1129794000907 active site 1129794000908 SAM binding site [chemical binding]; other site 1129794000909 homodimer interface [polypeptide binding]; other site 1129794000910 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1129794000911 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794000912 ATP binding site [chemical binding]; other site 1129794000913 Mg++ binding site [ion binding]; other site 1129794000914 motif III; other site 1129794000915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794000916 nucleotide binding region [chemical binding]; other site 1129794000917 ATP-binding site [chemical binding]; other site 1129794000918 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1129794000919 putative RNA binding site [nucleotide binding]; other site 1129794000920 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1129794000921 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1129794000922 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1129794000923 putative NTP binding site [chemical binding]; other site 1129794000924 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1129794000925 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1129794000926 putative active site [active] 1129794000927 putative nucleic acid binding site [nucleotide binding]; other site 1129794000928 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1129794000929 Transposase; Region: HTH_Tnp_1; cl17663 1129794000930 putative transposase OrfB; Reviewed; Region: PHA02517 1129794000931 Integrase core domain; Region: rve; pfam00665 1129794000932 Integrase core domain; Region: rve_3; pfam13683 1129794000933 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1129794000934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000935 binding surface 1129794000936 TPR motif; other site 1129794000937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000938 TPR motif; other site 1129794000939 binding surface 1129794000940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794000941 binding surface 1129794000942 TPR motif; other site 1129794000943 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1129794000944 FtsH protease regulator HflC; Provisional; Region: PRK11029 1129794000945 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1129794000946 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1129794000947 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1129794000948 HflK protein; Region: hflK; TIGR01933 1129794000949 HflX GTPase family; Region: HflX; cd01878 1129794000950 Switch II region; other site 1129794000951 GTP/Mg2+ binding site [chemical binding]; other site 1129794000952 G4 box; other site 1129794000953 G5 box; other site 1129794000954 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1129794000955 HflX GTPase family; Region: HflX; cd01878 1129794000956 G1 box; other site 1129794000957 Switch I region; other site 1129794000958 G2 box; other site 1129794000959 G3 box; other site 1129794000960 bacterial Hfq-like; Region: Hfq; cd01716 1129794000961 hexamer interface [polypeptide binding]; other site 1129794000962 Sm1 motif; other site 1129794000963 RNA binding site [nucleotide binding]; other site 1129794000964 Sm2 motif; other site 1129794000965 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1129794000966 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1129794000967 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1129794000968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794000969 ATP binding site [chemical binding]; other site 1129794000970 Mg2+ binding site [ion binding]; other site 1129794000971 G-X-G motif; other site 1129794000972 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1129794000973 ATP binding site [chemical binding]; other site 1129794000974 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 1129794000975 AMIN domain; Region: AMIN; pfam11741 1129794000976 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1129794000977 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1129794000978 active site 1129794000979 metal binding site [ion binding]; metal-binding site 1129794000980 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1129794000981 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1129794000982 putative carbohydrate kinase; Provisional; Region: PRK10565 1129794000983 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1129794000984 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1129794000985 putative substrate binding site [chemical binding]; other site 1129794000986 putative ATP binding site [chemical binding]; other site 1129794000987 epoxyqueuosine reductase; Region: TIGR00276 1129794000988 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1129794000989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794000990 S-adenosylmethionine binding site [chemical binding]; other site 1129794000991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794000992 NAD(P) binding site [chemical binding]; other site 1129794000993 active site 1129794000994 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1129794000995 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794000996 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794000997 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1129794000998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1129794000999 Winged helix-turn helix; Region: HTH_33; pfam13592 1129794001000 Homeodomain-like domain; Region: HTH_23; pfam13384 1129794001001 Winged helix-turn helix; Region: HTH_29; pfam13551 1129794001002 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1129794001003 MULE transposase domain; Region: MULE; pfam10551 1129794001004 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1129794001005 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1129794001006 catalytic residues [active] 1129794001007 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1129794001008 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1129794001009 active site 1129794001010 Zn binding site [ion binding]; other site 1129794001011 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1129794001012 catalytic core [active] 1129794001013 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1129794001014 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1129794001015 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1129794001016 putative active site [active] 1129794001017 putative substrate binding site [chemical binding]; other site 1129794001018 putative cosubstrate binding site; other site 1129794001019 catalytic site [active] 1129794001020 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1129794001021 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1129794001022 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1129794001023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794001024 ATP binding site [chemical binding]; other site 1129794001025 putative Mg++ binding site [ion binding]; other site 1129794001026 nucleotide binding region [chemical binding]; other site 1129794001027 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1129794001028 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1129794001029 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1129794001030 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1129794001031 Transglycosylase; Region: Transgly; pfam00912 1129794001032 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1129794001033 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1129794001034 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1129794001035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794001036 catalytic residue [active] 1129794001037 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1129794001038 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1129794001039 active site residue [active] 1129794001040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794001041 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1129794001042 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1129794001043 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1129794001044 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 1129794001045 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1129794001046 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1129794001047 heat shock protein HtpX; Provisional; Region: PRK05457 1129794001048 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1129794001049 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1129794001050 cyclase homology domain; Region: CHD; cd07302 1129794001051 nucleotidyl binding site; other site 1129794001052 metal binding site [ion binding]; metal-binding site 1129794001053 dimer interface [polypeptide binding]; other site 1129794001054 binding surface 1129794001055 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1129794001056 TPR motif; other site 1129794001057 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1129794001058 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1129794001059 inhibitor-cofactor binding pocket; inhibition site 1129794001060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794001061 catalytic residue [active] 1129794001062 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1129794001063 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1129794001064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1129794001065 MULE transposase domain; Region: MULE; pfam10551 1129794001066 Integrase core domain; Region: rve_2; pfam13333 1129794001067 Integrase core domain; Region: rve; pfam00665 1129794001068 Transposase; Region: HTH_Tnp_1; pfam01527 1129794001069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794001070 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1129794001071 pentamer interface [polypeptide binding]; other site 1129794001072 dodecaamer interface [polypeptide binding]; other site 1129794001073 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1129794001074 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1129794001075 tetramer interface [polypeptide binding]; other site 1129794001076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794001077 catalytic residue [active] 1129794001078 Aluminium induced protein; Region: DUF3700; pfam12481 1129794001079 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1129794001080 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1129794001081 active site 1129794001082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1129794001083 Coenzyme A binding pocket [chemical binding]; other site 1129794001084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1129794001085 NADH dehydrogenase subunit 5; Provisional; Region: ND5; MTH00208 1129794001086 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1129794001087 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1129794001088 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1129794001089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794001090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794001091 putative substrate translocation pore; other site 1129794001092 DNA polymerase IV; Validated; Region: PRK02406 1129794001093 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1129794001094 DNA binding site [nucleotide binding] 1129794001095 active site 1129794001096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 1129794001097 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1129794001098 ApbE family; Region: ApbE; pfam02424 1129794001099 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1129794001100 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794001101 catalytic loop [active] 1129794001102 iron binding site [ion binding]; other site 1129794001103 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1129794001104 FAD binding pocket [chemical binding]; other site 1129794001105 FAD binding motif [chemical binding]; other site 1129794001106 phosphate binding motif [ion binding]; other site 1129794001107 beta-alpha-beta structure motif; other site 1129794001108 NAD binding pocket [chemical binding]; other site 1129794001109 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1129794001110 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1129794001111 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1129794001112 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1129794001113 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1129794001114 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1129794001115 E3 interaction surface; other site 1129794001116 lipoyl attachment site [posttranslational modification]; other site 1129794001117 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1129794001118 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1129794001119 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1129794001120 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1129794001121 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1129794001122 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1129794001123 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1129794001124 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1129794001125 DctM-like transporters; Region: DctM; pfam06808 1129794001126 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1129794001127 BolA-like protein; Region: BolA; cl00386 1129794001128 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1129794001129 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1129794001130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1129794001131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1129794001132 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1129794001133 active site 1129794001134 poxB regulator PoxA; Provisional; Region: PRK09350 1129794001135 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1129794001136 motif 1; other site 1129794001137 dimer interface [polypeptide binding]; other site 1129794001138 active site 1129794001139 motif 2; other site 1129794001140 motif 3; other site 1129794001141 elongation factor P; Validated; Region: PRK00529 1129794001142 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1129794001143 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1129794001144 RNA binding site [nucleotide binding]; other site 1129794001145 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1129794001146 RNA binding site [nucleotide binding]; other site 1129794001147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794001148 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1129794001149 FeS/SAM binding site; other site 1129794001150 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043 1129794001151 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1129794001152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001153 ATP binding site [chemical binding]; other site 1129794001154 Mg2+ binding site [ion binding]; other site 1129794001155 G-X-G motif; other site 1129794001156 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1129794001157 anchoring element; other site 1129794001158 dimer interface [polypeptide binding]; other site 1129794001159 ATP binding site [chemical binding]; other site 1129794001160 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1129794001161 active site 1129794001162 metal binding site [ion binding]; metal-binding site 1129794001163 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1129794001164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794001165 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1129794001166 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1129794001167 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1129794001168 active site 1129794001169 metal binding site [ion binding]; metal-binding site 1129794001170 hexamer interface [polypeptide binding]; other site 1129794001171 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 1129794001172 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1129794001173 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1129794001174 dimer interface [polypeptide binding]; other site 1129794001175 ADP-ribose binding site [chemical binding]; other site 1129794001176 active site 1129794001177 nudix motif; other site 1129794001178 metal binding site [ion binding]; metal-binding site 1129794001179 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1129794001180 Ion transport protein; Region: Ion_trans; pfam00520 1129794001181 ferrochelatase; Reviewed; Region: hemH; PRK00035 1129794001182 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1129794001183 C-terminal domain interface [polypeptide binding]; other site 1129794001184 active site 1129794001185 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1129794001186 active site 1129794001187 N-terminal domain interface [polypeptide binding]; other site 1129794001188 Protein of unknown function (DUF819); Region: DUF819; cl02317 1129794001189 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1129794001190 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1129794001191 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1129794001192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1129794001193 Walker A/P-loop; other site 1129794001194 ATP binding site [chemical binding]; other site 1129794001195 Q-loop/lid; other site 1129794001196 ABC transporter signature motif; other site 1129794001197 Walker B; other site 1129794001198 D-loop; other site 1129794001199 H-loop/switch region; other site 1129794001200 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1129794001201 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1129794001202 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1129794001203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794001204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1129794001205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794001206 dimer interface [polypeptide binding]; other site 1129794001207 phosphorylation site [posttranslational modification] 1129794001208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001209 ATP binding site [chemical binding]; other site 1129794001210 Mg2+ binding site [ion binding]; other site 1129794001211 G-X-G motif; other site 1129794001212 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1129794001213 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1129794001214 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794001215 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 1129794001216 putative C-terminal domain interface [polypeptide binding]; other site 1129794001217 putative GSH binding site (G-site) [chemical binding]; other site 1129794001218 putative dimer interface [polypeptide binding]; other site 1129794001219 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794001220 N-terminal domain interface [polypeptide binding]; other site 1129794001221 dimer interface [polypeptide binding]; other site 1129794001222 substrate binding pocket (H-site) [chemical binding]; other site 1129794001223 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1129794001224 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1129794001225 putative active site; other site 1129794001226 catalytic triad [active] 1129794001227 putative dimer interface [polypeptide binding]; other site 1129794001228 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1129794001229 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1129794001230 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794001231 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 1129794001232 active site 1129794001233 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1129794001234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794001235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794001236 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794001237 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794001238 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794001239 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794001240 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794001241 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 1129794001242 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1129794001243 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1129794001244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794001245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794001246 dimer interface [polypeptide binding]; other site 1129794001247 phosphorylation site [posttranslational modification] 1129794001248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001249 ATP binding site [chemical binding]; other site 1129794001250 Mg2+ binding site [ion binding]; other site 1129794001251 G-X-G motif; other site 1129794001252 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794001253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794001254 active site 1129794001255 phosphorylation site [posttranslational modification] 1129794001256 intermolecular recognition site; other site 1129794001257 dimerization interface [polypeptide binding]; other site 1129794001258 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1129794001259 putative binding surface; other site 1129794001260 active site 1129794001261 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1129794001262 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1129794001263 CAP-like domain; other site 1129794001264 active site 1129794001265 primary dimer interface [polypeptide binding]; other site 1129794001266 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1129794001267 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1129794001268 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1129794001269 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1129794001270 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1129794001271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794001272 Walker A/P-loop; other site 1129794001273 ATP binding site [chemical binding]; other site 1129794001274 Q-loop/lid; other site 1129794001275 ABC transporter signature motif; other site 1129794001276 Walker B; other site 1129794001277 D-loop; other site 1129794001278 H-loop/switch region; other site 1129794001279 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1129794001280 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1129794001281 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1129794001282 P loop; other site 1129794001283 GTP binding site [chemical binding]; other site 1129794001284 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1129794001285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794001286 S-adenosylmethionine binding site [chemical binding]; other site 1129794001287 Protein of unknown function (DUF416); Region: DUF416; pfam04222 1129794001288 MarC family integral membrane protein; Region: MarC; cl00919 1129794001289 Helix-turn-helix domain; Region: HTH_17; cl17695 1129794001290 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 1129794001291 interface (dimer of trimers) [polypeptide binding]; other site 1129794001292 Substrate-binding/catalytic site; other site 1129794001293 Zn-binding sites [ion binding]; other site 1129794001294 Peptidase; Region: DUF3663; pfam12404 1129794001295 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 1129794001296 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1129794001297 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1129794001298 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 1129794001299 active site 1129794001300 HIGH motif; other site 1129794001301 nucleotide binding site [chemical binding]; other site 1129794001302 KMSKS motif; other site 1129794001303 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1129794001304 active site 1129794001305 NTP binding site [chemical binding]; other site 1129794001306 metal binding triad [ion binding]; metal-binding site 1129794001307 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1129794001308 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1129794001309 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1129794001310 catalytic center binding site [active] 1129794001311 ATP binding site [chemical binding]; other site 1129794001312 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1129794001313 oligomerization interface [polypeptide binding]; other site 1129794001314 active site 1129794001315 metal binding site [ion binding]; metal-binding site 1129794001316 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1129794001317 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1129794001318 active site 1129794001319 ATP-binding site [chemical binding]; other site 1129794001320 pantoate-binding site; other site 1129794001321 HXXH motif; other site 1129794001322 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794001323 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794001324 catalytic residue [active] 1129794001325 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794001326 EAL domain; Region: EAL; pfam00563 1129794001327 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794001328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794001329 S-adenosylmethionine binding site [chemical binding]; other site 1129794001330 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1129794001331 inner membrane transport permease; Provisional; Region: PRK15066 1129794001332 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1129794001333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794001334 Walker A/P-loop; other site 1129794001335 ATP binding site [chemical binding]; other site 1129794001336 Q-loop/lid; other site 1129794001337 ABC transporter signature motif; other site 1129794001338 Walker B; other site 1129794001339 D-loop; other site 1129794001340 H-loop/switch region; other site 1129794001341 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1129794001342 active site 1129794001343 catalytic site [active] 1129794001344 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1129794001345 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1129794001346 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1129794001347 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1129794001348 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1129794001349 metal ion-dependent adhesion site (MIDAS); other site 1129794001350 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 1129794001351 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1129794001352 ligand binding site [chemical binding]; other site 1129794001353 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 1129794001354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794001355 active site 1129794001356 phosphorylation site [posttranslational modification] 1129794001357 intermolecular recognition site; other site 1129794001358 dimerization interface [polypeptide binding]; other site 1129794001359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794001360 DNA binding site [nucleotide binding] 1129794001361 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 1129794001362 DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622 1129794001363 putative ligand binding site [chemical binding]; other site 1129794001364 HAMP domain; Region: HAMP; pfam00672 1129794001365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794001366 dimer interface [polypeptide binding]; other site 1129794001367 phosphorylation site [posttranslational modification] 1129794001368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001369 ATP binding site [chemical binding]; other site 1129794001370 Mg2+ binding site [ion binding]; other site 1129794001371 G-X-G motif; other site 1129794001372 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1129794001373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1129794001374 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1129794001375 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1129794001376 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1129794001377 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1129794001378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794001379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794001380 putative substrate translocation pore; other site 1129794001381 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1129794001382 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1129794001383 Metal-binding active site; metal-binding site 1129794001384 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1129794001385 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1129794001386 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1129794001387 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1129794001388 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1129794001389 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1129794001390 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 1129794001391 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1129794001392 dimerization interface [polypeptide binding]; other site 1129794001393 putative ATP binding site [chemical binding]; other site 1129794001394 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1129794001395 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1129794001396 active site residue [active] 1129794001397 Fic family protein [Function unknown]; Region: COG3177 1129794001398 Fic/DOC family; Region: Fic; pfam02661 1129794001399 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1129794001400 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1129794001401 glutaminase active site [active] 1129794001402 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1129794001403 dimer interface [polypeptide binding]; other site 1129794001404 active site 1129794001405 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1129794001406 dimer interface [polypeptide binding]; other site 1129794001407 active site 1129794001408 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1129794001409 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1129794001410 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1129794001411 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1129794001412 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1129794001413 Substrate binding site; other site 1129794001414 Mg++ binding site; other site 1129794001415 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1129794001416 active site 1129794001417 substrate binding site [chemical binding]; other site 1129794001418 CoA binding site [chemical binding]; other site 1129794001419 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 1129794001420 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794001421 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794001422 metal binding site [ion binding]; metal-binding site 1129794001423 active site 1129794001424 I-site; other site 1129794001425 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1129794001426 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1129794001427 DNA binding site [nucleotide binding] 1129794001428 active site 1129794001429 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1129794001430 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1129794001431 minor groove reading motif; other site 1129794001432 helix-hairpin-helix signature motif; other site 1129794001433 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1129794001434 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1129794001435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794001436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794001437 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794001438 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794001439 arginine decarboxylase; Provisional; Region: PRK05354 1129794001440 ParB-like nuclease domain; Region: ParBc; cl02129 1129794001441 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1129794001442 dimer interface [polypeptide binding]; other site 1129794001443 active site 1129794001444 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1129794001445 catalytic residues [active] 1129794001446 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1129794001447 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1129794001448 MgtE intracellular N domain; Region: MgtE_N; smart00924 1129794001449 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1129794001450 Divalent cation transporter; Region: MgtE; cl00786 1129794001451 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1129794001452 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1129794001453 putative active site [active] 1129794001454 catalytic triad [active] 1129794001455 putative dimer interface [polypeptide binding]; other site 1129794001456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794001457 non-specific DNA binding site [nucleotide binding]; other site 1129794001458 salt bridge; other site 1129794001459 sequence-specific DNA binding site [nucleotide binding]; other site 1129794001460 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1129794001461 nucleoside/Zn binding site; other site 1129794001462 dimer interface [polypeptide binding]; other site 1129794001463 catalytic motif [active] 1129794001464 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1129794001465 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1129794001466 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 1129794001467 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1129794001468 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794001469 substrate binding pocket [chemical binding]; other site 1129794001470 membrane-bound complex binding site; other site 1129794001471 hinge residues; other site 1129794001472 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1129794001473 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1129794001474 DNA binding residues [nucleotide binding] 1129794001475 Predicted permeases [General function prediction only]; Region: COG0701 1129794001476 Predicted transcriptional regulators [Transcription]; Region: COG1725 1129794001477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794001478 DNA-binding site [nucleotide binding]; DNA binding site 1129794001479 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1129794001480 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1129794001481 Walker A/P-loop; other site 1129794001482 ATP binding site [chemical binding]; other site 1129794001483 Q-loop/lid; other site 1129794001484 ABC transporter signature motif; other site 1129794001485 Walker B; other site 1129794001486 D-loop; other site 1129794001487 H-loop/switch region; other site 1129794001488 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1129794001489 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794001490 putative catalytic residue [active] 1129794001491 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794001492 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794001493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794001494 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794001495 short chain dehydrogenase; Provisional; Region: PRK12937 1129794001496 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1129794001497 NADP binding site [chemical binding]; other site 1129794001498 homodimer interface [polypeptide binding]; other site 1129794001499 active site 1129794001500 substrate binding site [chemical binding]; other site 1129794001501 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1129794001502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1129794001503 putative metal binding site [ion binding]; other site 1129794001504 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1129794001505 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1129794001506 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794001507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794001508 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794001509 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1129794001510 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1129794001511 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1129794001512 DNA binding site [nucleotide binding] 1129794001513 Int/Topo IB signature motif; other site 1129794001514 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1129794001515 translocation protein TolB; Provisional; Region: tolB; PRK05137 1129794001516 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1129794001517 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1129794001518 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794001519 catalytic residues [active] 1129794001520 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 1129794001521 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 1129794001522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794001523 TPR motif; other site 1129794001524 binding surface 1129794001525 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1129794001526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794001527 binding surface 1129794001528 TPR motif; other site 1129794001529 TPR repeat; Region: TPR_11; pfam13414 1129794001530 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1129794001531 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1129794001532 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1129794001533 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1129794001534 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794001535 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794001536 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794001537 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1129794001538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1129794001539 DNA binding site [nucleotide binding] 1129794001540 domain linker motif; other site 1129794001541 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1129794001542 putative dimerization interface [polypeptide binding]; other site 1129794001543 putative ligand binding site [chemical binding]; other site 1129794001544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794001545 Trehalase; Region: Trehalase; cl17346 1129794001546 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1129794001547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794001548 acyl-activating enzyme (AAE) consensus motif; other site 1129794001549 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1129794001550 acyl-activating enzyme (AAE) consensus motif; other site 1129794001551 putative AMP binding site [chemical binding]; other site 1129794001552 putative active site [active] 1129794001553 putative CoA binding site [chemical binding]; other site 1129794001554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794001555 dimer interface [polypeptide binding]; other site 1129794001556 phosphorylation site [posttranslational modification] 1129794001557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001558 Mg2+ binding site [ion binding]; other site 1129794001559 G-X-G motif; other site 1129794001560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001561 ATP binding site [chemical binding]; other site 1129794001562 G-X-G motif; other site 1129794001563 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794001564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794001565 active site 1129794001566 phosphorylation site [posttranslational modification] 1129794001567 intermolecular recognition site; other site 1129794001568 dimerization interface [polypeptide binding]; other site 1129794001569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794001570 PAS domain; Region: PAS_9; pfam13426 1129794001571 putative active site [active] 1129794001572 heme pocket [chemical binding]; other site 1129794001573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794001574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794001575 metal binding site [ion binding]; metal-binding site 1129794001576 active site 1129794001577 I-site; other site 1129794001578 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794001579 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1129794001580 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1129794001581 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1129794001582 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794001583 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794001584 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1129794001585 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1129794001586 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1129794001587 protein binding site [polypeptide binding]; other site 1129794001588 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1129794001589 Domain interface; other site 1129794001590 Peptide binding site; other site 1129794001591 Active site tetrad [active] 1129794001592 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 1129794001593 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1129794001594 putative active site [active] 1129794001595 metal binding site [ion binding]; metal-binding site 1129794001596 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1129794001597 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1129794001598 dimer interface [polypeptide binding]; other site 1129794001599 active site 1129794001600 metal binding site [ion binding]; metal-binding site 1129794001601 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1129794001602 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1129794001603 potential catalytic triad [active] 1129794001604 conserved cys residue [active] 1129794001605 transcriptional regulator; Provisional; Region: PRK10632 1129794001606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794001607 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1129794001608 putative effector binding pocket; other site 1129794001609 dimerization interface [polypeptide binding]; other site 1129794001610 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1129794001611 active site 1129794001612 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1129794001613 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1129794001614 ligand binding site [chemical binding]; other site 1129794001615 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1129794001616 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794001617 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1129794001618 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794001619 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794001620 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794001621 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1129794001622 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1129794001623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1129794001624 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1129794001625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1129794001626 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1129794001627 Penicillinase repressor; Region: Pencillinase_R; cl17580 1129794001628 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794001629 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794001630 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794001631 metal binding site [ion binding]; metal-binding site 1129794001632 active site 1129794001633 I-site; other site 1129794001634 VacJ like lipoprotein; Region: VacJ; cl01073 1129794001635 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1129794001636 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1129794001637 dimer interface [polypeptide binding]; other site 1129794001638 active site 1129794001639 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1129794001640 catalytic residues [active] 1129794001641 substrate binding site [chemical binding]; other site 1129794001642 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1129794001643 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1129794001644 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1129794001645 AAA domain; Region: AAA_28; pfam13521 1129794001646 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1129794001647 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1129794001648 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1129794001649 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794001650 catalytic residue [active] 1129794001651 MAPEG family; Region: MAPEG; cl09190 1129794001652 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1129794001653 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1129794001654 DNA binding residues [nucleotide binding] 1129794001655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794001656 dimer interface [polypeptide binding]; other site 1129794001657 putative CheW interface [polypeptide binding]; other site 1129794001658 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1129794001659 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1129794001660 putative catalytic residues [active] 1129794001661 putative nucleotide binding site [chemical binding]; other site 1129794001662 putative aspartate binding site [chemical binding]; other site 1129794001663 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1129794001664 dimer interface [polypeptide binding]; other site 1129794001665 putative threonine allosteric regulatory site; other site 1129794001666 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1129794001667 putative threonine allosteric regulatory site; other site 1129794001668 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1129794001669 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1129794001670 homoserine kinase; Provisional; Region: PRK01212 1129794001671 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1129794001672 threonine synthase; Validated; Region: PRK09225 1129794001673 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1129794001674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794001675 catalytic residue [active] 1129794001676 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1129794001677 ligand binding site [chemical binding]; other site 1129794001678 UGI interface [polypeptide binding]; other site 1129794001679 catalytic site [active] 1129794001680 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1129794001681 active site 1129794001682 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 1129794001683 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1129794001684 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1129794001685 active site 1129794001686 dimer interface [polypeptide binding]; other site 1129794001687 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1129794001688 dimer interface [polypeptide binding]; other site 1129794001689 active site 1129794001690 transaldolase-like protein; Provisional; Region: PTZ00411 1129794001691 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1129794001692 active site 1129794001693 dimer interface [polypeptide binding]; other site 1129794001694 catalytic residue [active] 1129794001695 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1129794001696 hypothetical protein; Validated; Region: PRK02101 1129794001697 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794001698 DNA polymerase II; Reviewed; Region: PRK05762 1129794001699 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1129794001700 active site 1129794001701 catalytic site [active] 1129794001702 substrate binding site [chemical binding]; other site 1129794001703 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1129794001704 active site 1129794001705 metal-binding site 1129794001706 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1129794001707 catalytic residues [active] 1129794001708 hinge region; other site 1129794001709 alpha helical domain; other site 1129794001710 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1129794001711 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1129794001712 catalytic residues [active] 1129794001713 hinge region; other site 1129794001714 alpha helical domain; other site 1129794001715 serine/threonine protein kinase; Provisional; Region: PRK11768 1129794001716 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1129794001717 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1129794001718 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1129794001719 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1129794001720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001721 ATP binding site [chemical binding]; other site 1129794001722 G-X-G motif; other site 1129794001723 sensor protein RstB; Provisional; Region: PRK10604 1129794001724 Beta propeller domain; Region: Beta_propel; pfam09826 1129794001725 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 1129794001726 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794001727 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794001728 metal binding site [ion binding]; metal-binding site 1129794001729 active site 1129794001730 I-site; other site 1129794001731 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1129794001732 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1129794001733 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1129794001734 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1129794001735 HIGH motif; other site 1129794001736 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1129794001737 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1129794001738 active site 1129794001739 KMSKS motif; other site 1129794001740 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1129794001741 tRNA binding surface [nucleotide binding]; other site 1129794001742 anticodon binding site; other site 1129794001743 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1129794001744 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1129794001745 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1129794001746 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1129794001747 interface (dimer of trimers) [polypeptide binding]; other site 1129794001748 Substrate-binding/catalytic site; other site 1129794001749 Zn-binding sites [ion binding]; other site 1129794001750 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1129794001751 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1129794001752 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1129794001753 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1129794001754 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1129794001755 RDD family; Region: RDD; pfam06271 1129794001756 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1129794001757 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1129794001758 ligand binding site [chemical binding]; other site 1129794001759 homodimer interface [polypeptide binding]; other site 1129794001760 NAD(P) binding site [chemical binding]; other site 1129794001761 trimer interface B [polypeptide binding]; other site 1129794001762 trimer interface A [polypeptide binding]; other site 1129794001763 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1129794001764 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1129794001765 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1129794001766 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1129794001767 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1129794001768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794001769 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1129794001770 substrate binding pocket [chemical binding]; other site 1129794001771 dimerization interface [polypeptide binding]; other site 1129794001772 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1129794001773 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1129794001774 amidase; Provisional; Region: PRK08137 1129794001775 Amidase; Region: Amidase; cl11426 1129794001776 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1129794001777 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794001778 dimer interface [polypeptide binding]; other site 1129794001779 putative CheW interface [polypeptide binding]; other site 1129794001780 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1129794001781 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1129794001782 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1129794001783 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1129794001784 active site 1129794001785 catalytic tetrad [active] 1129794001786 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1129794001787 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1129794001788 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1129794001789 OmpW family; Region: OmpW; cl17427 1129794001790 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 1129794001791 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1129794001792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794001793 active site 1129794001794 phosphorylation site [posttranslational modification] 1129794001795 intermolecular recognition site; other site 1129794001796 dimerization interface [polypeptide binding]; other site 1129794001797 GAF domain; Region: GAF; pfam01590 1129794001798 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1129794001799 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1129794001800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794001801 putative active site [active] 1129794001802 heme pocket [chemical binding]; other site 1129794001803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794001804 dimer interface [polypeptide binding]; other site 1129794001805 phosphorylation site [posttranslational modification] 1129794001806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001807 ATP binding site [chemical binding]; other site 1129794001808 Mg2+ binding site [ion binding]; other site 1129794001809 G-X-G motif; other site 1129794001810 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794001811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794001812 active site 1129794001813 phosphorylation site [posttranslational modification] 1129794001814 intermolecular recognition site; other site 1129794001815 dimerization interface [polypeptide binding]; other site 1129794001816 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1129794001817 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1129794001818 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1129794001819 active site 1129794001820 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 1129794001821 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1129794001822 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1129794001823 Sodium Bile acid symporter family; Region: SBF; cl17470 1129794001824 Phospholipase A1; Region: PLA1; pfam02253 1129794001825 dimerization interface [polypeptide binding]; other site 1129794001826 substrate binding site [chemical binding]; other site 1129794001827 active site 1129794001828 calcium binding site [ion binding]; other site 1129794001829 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 1129794001830 PAS domain; Region: PAS_9; pfam13426 1129794001831 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794001832 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794001833 metal binding site [ion binding]; metal-binding site 1129794001834 active site 1129794001835 I-site; other site 1129794001836 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794001837 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1129794001838 apolar tunnel; other site 1129794001839 heme binding site [chemical binding]; other site 1129794001840 dimerization interface [polypeptide binding]; other site 1129794001841 Protein of unknown function (DUF3034); Region: DUF3034; pfam11231 1129794001842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794001843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794001844 metal binding site [ion binding]; metal-binding site 1129794001845 active site 1129794001846 I-site; other site 1129794001847 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794001848 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1129794001849 substrate binding site [chemical binding]; other site 1129794001850 activation loop (A-loop); other site 1129794001851 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1129794001852 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1129794001853 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1129794001854 Cl binding site [ion binding]; other site 1129794001855 oligomer interface [polypeptide binding]; other site 1129794001856 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 1129794001857 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1129794001858 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1129794001859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794001860 S-adenosylmethionine binding site [chemical binding]; other site 1129794001861 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794001862 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1129794001863 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1129794001864 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794001865 Entericidin EcnA/B family; Region: Entericidin; cl02322 1129794001866 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794001867 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 1129794001868 DNA photolyase; Region: DNA_photolyase; pfam00875 1129794001869 DNA photolyase; Region: DNA_photolyase; pfam00875 1129794001870 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1129794001871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794001872 PGAP1-like protein; Region: PGAP1; pfam07819 1129794001873 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794001874 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794001875 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794001876 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794001877 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1129794001878 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1129794001879 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1129794001880 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1129794001881 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 1129794001882 DNA photolyase; Region: DNA_photolyase; pfam00875 1129794001883 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 1129794001884 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 1129794001885 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1129794001886 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1129794001887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794001888 S-adenosylmethionine binding site [chemical binding]; other site 1129794001889 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1129794001890 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1129794001891 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1129794001892 choline dehydrogenase; Validated; Region: PRK02106 1129794001893 choline dehydrogenase; Validated; Region: PRK02106 1129794001894 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1129794001895 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794001896 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1129794001897 active site 1129794001898 CAAX protease self-immunity; Region: Abi; pfam02517 1129794001899 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1129794001900 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1129794001901 Na binding site [ion binding]; other site 1129794001902 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794001903 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794001904 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1129794001905 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1129794001906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794001907 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1129794001908 pyrimidine utilization protein A; Region: RutA; TIGR03612 1129794001909 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1129794001910 active site 1129794001911 dimer interface [polypeptide binding]; other site 1129794001912 non-prolyl cis peptide bond; other site 1129794001913 insertion regions; other site 1129794001914 Isochorismatase family; Region: Isochorismatase; pfam00857 1129794001915 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1129794001916 catalytic triad [active] 1129794001917 conserved cis-peptide bond; other site 1129794001918 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1129794001919 homotrimer interaction site [polypeptide binding]; other site 1129794001920 putative active site [active] 1129794001921 pyrimidine utilization protein D; Region: RutD; TIGR03611 1129794001922 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1129794001923 putative FMN binding site [chemical binding]; other site 1129794001924 Flavin Reductases; Region: FlaRed; cl00801 1129794001925 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1129794001926 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1129794001927 tetrameric interface [polypeptide binding]; other site 1129794001928 NAD binding site [chemical binding]; other site 1129794001929 catalytic residues [active] 1129794001930 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1129794001931 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1129794001932 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1129794001933 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1129794001934 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1129794001935 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1129794001936 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794001937 catalytic residue [active] 1129794001938 HAMP domain; Region: HAMP; pfam00672 1129794001939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794001940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794001941 dimer interface [polypeptide binding]; other site 1129794001942 phosphorylation site [posttranslational modification] 1129794001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794001944 ATP binding site [chemical binding]; other site 1129794001945 Mg2+ binding site [ion binding]; other site 1129794001946 G-X-G motif; other site 1129794001947 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794001948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794001949 active site 1129794001950 phosphorylation site [posttranslational modification] 1129794001951 intermolecular recognition site; other site 1129794001952 dimerization interface [polypeptide binding]; other site 1129794001953 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1129794001954 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1129794001955 YGGT family; Region: YGGT; pfam02325 1129794001956 YGGT family; Region: YGGT; pfam02325 1129794001957 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1129794001958 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1129794001959 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1129794001960 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1129794001961 catalytic residue [active] 1129794001962 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1129794001963 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1129794001964 Walker A motif; other site 1129794001965 ATP binding site [chemical binding]; other site 1129794001966 Walker B motif; other site 1129794001967 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 1129794001968 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1129794001969 Walker A motif; other site 1129794001970 ATP binding site [chemical binding]; other site 1129794001971 Walker B motif; other site 1129794001972 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1129794001973 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1129794001974 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1129794001975 active site 1129794001976 Int/Topo IB signature motif; other site 1129794001977 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1129794001978 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1129794001979 dimerization domain [polypeptide binding]; other site 1129794001980 dimer interface [polypeptide binding]; other site 1129794001981 catalytic residues [active] 1129794001982 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1129794001983 DHH family; Region: DHH; pfam01368 1129794001984 DHHA1 domain; Region: DHHA1; pfam02272 1129794001985 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1129794001986 Recombination protein O N terminal; Region: RecO_N; pfam11967 1129794001987 Recombination protein O C terminal; Region: RecO_C; pfam02565 1129794001988 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1129794001989 active site 1129794001990 hydrophilic channel; other site 1129794001991 dimerization interface [polypeptide binding]; other site 1129794001992 catalytic residues [active] 1129794001993 active site lid [active] 1129794001994 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1129794001995 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1129794001996 HD domain; Region: HD_4; pfam13328 1129794001997 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1129794001998 synthetase active site [active] 1129794001999 NTP binding site [chemical binding]; other site 1129794002000 metal binding site [ion binding]; metal-binding site 1129794002001 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1129794002002 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1129794002003 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1129794002004 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1129794002005 homodimer interface [polypeptide binding]; other site 1129794002006 metal binding site [ion binding]; metal-binding site 1129794002007 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1129794002008 homodimer interface [polypeptide binding]; other site 1129794002009 active site 1129794002010 putative chemical substrate binding site [chemical binding]; other site 1129794002011 metal binding site [ion binding]; metal-binding site 1129794002012 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794002013 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794002014 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794002015 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1129794002016 PA/protease or protease-like domain interface [polypeptide binding]; other site 1129794002017 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1129794002018 active site 1129794002019 substrate binding sites [chemical binding]; other site 1129794002020 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1129794002021 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 1129794002022 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 1129794002023 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 1129794002024 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1129794002025 D-cysteine desulfhydrase; Validated; Region: PRK03910 1129794002026 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1129794002027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794002028 catalytic residue [active] 1129794002029 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1129794002030 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1129794002031 active site 1129794002032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794002033 putative CheW interface [polypeptide binding]; other site 1129794002034 BCCT family transporter; Region: BCCT; pfam02028 1129794002035 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1129794002036 Fasciclin domain; Region: Fasciclin; pfam02469 1129794002037 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1129794002038 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1129794002039 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1129794002040 active site residue [active] 1129794002041 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1129794002042 EF-hand domain pair; Region: EF_hand_5; pfam13499 1129794002043 Ca2+ binding site [ion binding]; other site 1129794002044 putative S-transferase; Provisional; Region: PRK11752 1129794002045 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1129794002046 C-terminal domain interface [polypeptide binding]; other site 1129794002047 GSH binding site (G-site) [chemical binding]; other site 1129794002048 dimer interface [polypeptide binding]; other site 1129794002049 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1129794002050 dimer interface [polypeptide binding]; other site 1129794002051 N-terminal domain interface [polypeptide binding]; other site 1129794002052 active site 1129794002053 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1129794002054 cyanate hydratase; Validated; Region: PRK02866 1129794002055 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1129794002056 oligomer interface [polypeptide binding]; other site 1129794002057 active site 1129794002058 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1129794002059 active site 1129794002060 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1129794002061 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1129794002062 active site 1129794002063 ATP binding site [chemical binding]; other site 1129794002064 substrate binding site [chemical binding]; other site 1129794002065 activation loop (A-loop); other site 1129794002066 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1129794002067 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1129794002068 active site 1129794002069 dimer interface [polypeptide binding]; other site 1129794002070 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1129794002071 Melibiase; Region: Melibiase; pfam02065 1129794002072 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1129794002073 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794002074 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794002075 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1129794002076 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1129794002077 SapC; Region: SapC; pfam07277 1129794002078 putative transporter; Provisional; Region: PRK10484 1129794002079 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 1129794002080 Na binding site [ion binding]; other site 1129794002081 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1129794002082 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1129794002083 SapC; Region: SapC; pfam07277 1129794002084 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1129794002085 active site 1129794002086 catalytic residues [active] 1129794002087 glycerol kinase; Provisional; Region: glpK; PRK00047 1129794002088 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1129794002089 N- and C-terminal domain interface [polypeptide binding]; other site 1129794002090 active site 1129794002091 MgATP binding site [chemical binding]; other site 1129794002092 catalytic site [active] 1129794002093 metal binding site [ion binding]; metal-binding site 1129794002094 glycerol binding site [chemical binding]; other site 1129794002095 homotetramer interface [polypeptide binding]; other site 1129794002096 homodimer interface [polypeptide binding]; other site 1129794002097 FBP binding site [chemical binding]; other site 1129794002098 protein IIAGlc interface [polypeptide binding]; other site 1129794002099 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1129794002100 cell division protein MraZ; Reviewed; Region: PRK00326 1129794002101 MraZ protein; Region: MraZ; pfam02381 1129794002102 MraZ protein; Region: MraZ; pfam02381 1129794002103 MraW methylase family; Region: Methyltransf_5; pfam01795 1129794002104 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1129794002105 Cell division protein FtsL; Region: FtsL; pfam04999 1129794002106 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1129794002107 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1129794002108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1129794002109 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1129794002110 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1129794002111 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1129794002112 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1129794002113 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1129794002114 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1129794002115 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1129794002116 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1129794002117 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1129794002118 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1129794002119 Mg++ binding site [ion binding]; other site 1129794002120 putative catalytic motif [active] 1129794002121 putative substrate binding site [chemical binding]; other site 1129794002122 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1129794002123 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1129794002124 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1129794002125 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1129794002126 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1129794002127 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1129794002128 active site 1129794002129 homodimer interface [polypeptide binding]; other site 1129794002130 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1129794002131 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1129794002132 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1129794002133 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1129794002134 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1129794002135 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1129794002136 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794002137 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1129794002138 Cell division protein FtsQ; Region: FtsQ; pfam03799 1129794002139 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1129794002140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1129794002141 nucleotide binding site [chemical binding]; other site 1129794002142 Cell division protein FtsA; Region: FtsA; pfam14450 1129794002143 cell division protein FtsZ; Validated; Region: PRK09330 1129794002144 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1129794002145 nucleotide binding site [chemical binding]; other site 1129794002146 SulA interaction site; other site 1129794002147 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1129794002148 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1129794002149 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1129794002150 Peptidase family M23; Region: Peptidase_M23; pfam01551 1129794002151 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1129794002152 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1129794002153 SEC-C motif; Region: SEC-C; pfam02810 1129794002154 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1129794002155 active site 1129794002156 8-oxo-dGMP binding site [chemical binding]; other site 1129794002157 nudix motif; other site 1129794002158 metal binding site [ion binding]; metal-binding site 1129794002159 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1129794002160 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1129794002161 NAD(P) binding site [chemical binding]; other site 1129794002162 substrate binding site [chemical binding]; other site 1129794002163 dimer interface [polypeptide binding]; other site 1129794002164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794002165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794002166 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1129794002167 putative effector binding pocket; other site 1129794002168 dimerization interface [polypeptide binding]; other site 1129794002169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794002170 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794002171 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1129794002172 classical (c) SDRs; Region: SDR_c; cd05233 1129794002173 NAD(P) binding site [chemical binding]; other site 1129794002174 active site 1129794002175 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1129794002176 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1129794002177 active site 1129794002178 dimer interface [polypeptide binding]; other site 1129794002179 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1129794002180 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1129794002181 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1129794002182 GAF domain; Region: GAF; pfam01590 1129794002183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794002184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794002185 dimer interface [polypeptide binding]; other site 1129794002186 phosphorylation site [posttranslational modification] 1129794002187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794002188 ATP binding site [chemical binding]; other site 1129794002189 Mg2+ binding site [ion binding]; other site 1129794002190 G-X-G motif; other site 1129794002191 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794002192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794002193 active site 1129794002194 phosphorylation site [posttranslational modification] 1129794002195 intermolecular recognition site; other site 1129794002196 dimerization interface [polypeptide binding]; other site 1129794002197 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1129794002198 active site 1129794002199 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1129794002200 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1129794002201 substrate binding site [chemical binding]; other site 1129794002202 dimer interface [polypeptide binding]; other site 1129794002203 ATP binding site [chemical binding]; other site 1129794002204 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1129794002205 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1129794002206 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1129794002207 active site 1129794002208 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1129794002209 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1129794002210 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1129794002211 putative deacylase active site [active] 1129794002212 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1129794002213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794002214 Coenzyme A binding pocket [chemical binding]; other site 1129794002215 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1129794002216 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 1129794002217 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1129794002218 Protein of unknown function DUF58; Region: DUF58; pfam01882 1129794002219 MoxR-like ATPases [General function prediction only]; Region: COG0714 1129794002220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794002221 Walker A motif; other site 1129794002222 ATP binding site [chemical binding]; other site 1129794002223 Walker B motif; other site 1129794002224 arginine finger; other site 1129794002225 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1129794002226 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1129794002227 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1129794002228 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1129794002229 active site 1129794002230 catalytic triad [active] 1129794002231 oxyanion hole [active] 1129794002232 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1129794002233 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1129794002234 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1129794002235 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1129794002236 active site 1129794002237 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794002238 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794002239 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1129794002240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794002241 Walker A/P-loop; other site 1129794002242 ATP binding site [chemical binding]; other site 1129794002243 ABC transporter signature motif; other site 1129794002244 Walker B; other site 1129794002245 D-loop; other site 1129794002246 H-loop/switch region; other site 1129794002247 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 1129794002248 active site 1129794002249 catalytic triad [active] 1129794002250 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1129794002251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794002252 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794002253 DNA binding residues [nucleotide binding] 1129794002254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1129794002255 dimerization interface [polypeptide binding]; other site 1129794002256 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1129794002257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794002258 dimer interface [polypeptide binding]; other site 1129794002259 putative CheW interface [polypeptide binding]; other site 1129794002260 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1129794002261 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1129794002262 active site 1129794002263 metal binding site [ion binding]; metal-binding site 1129794002264 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1129794002265 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1129794002266 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1129794002267 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1129794002268 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1129794002269 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1129794002270 SurA N-terminal domain; Region: SurA_N; pfam09312 1129794002271 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1129794002272 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1129794002273 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1129794002274 OstA-like protein; Region: OstA; cl00844 1129794002275 Phosphotransferase enzyme family; Region: APH; pfam01636 1129794002276 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1129794002277 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1129794002278 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1129794002279 Substrate binding site; other site 1129794002280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794002281 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1129794002282 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1129794002283 putative metal binding site [ion binding]; other site 1129794002284 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1129794002285 HSP70 interaction site [polypeptide binding]; other site 1129794002286 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1129794002287 Sodium Bile acid symporter family; Region: SBF; cl17470 1129794002288 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1129794002289 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1129794002290 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1129794002291 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1129794002292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794002293 active site 1129794002294 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1129794002295 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794002296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794002297 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794002298 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794002299 Protein export membrane protein; Region: SecD_SecF; cl14618 1129794002300 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1129794002301 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 1129794002302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1129794002303 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1129794002304 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1129794002305 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1129794002306 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1129794002307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794002308 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1129794002309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794002310 DNA binding residues [nucleotide binding] 1129794002311 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1129794002312 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1129794002313 active site 1129794002314 metal binding site [ion binding]; metal-binding site 1129794002315 interdomain interaction site; other site 1129794002316 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1129794002317 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1129794002318 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1129794002319 Yqey-like protein; Region: YqeY; pfam09424 1129794002320 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1129794002321 UGMP family protein; Validated; Region: PRK09604 1129794002322 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1129794002323 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1129794002324 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1129794002325 homooctamer interface [polypeptide binding]; other site 1129794002326 active site 1129794002327 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1129794002328 catalytic center binding site [active] 1129794002329 ATP binding site [chemical binding]; other site 1129794002330 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1129794002331 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1129794002332 nucleotide binding site/active site [active] 1129794002333 HIT family signature motif; other site 1129794002334 catalytic residue [active] 1129794002335 Nudix hydrolase homolog; Region: PLN02791 1129794002336 Nudix hydrolase homolog; Region: PLN02791 1129794002337 HDOD domain; Region: HDOD; pfam08668 1129794002338 Putative exonuclease, RdgC; Region: RdgC; pfam04381 1129794002339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1129794002340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794002341 ATP binding site [chemical binding]; other site 1129794002342 Mg2+ binding site [ion binding]; other site 1129794002343 G-X-G motif; other site 1129794002344 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1129794002345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794002346 active site 1129794002347 phosphorylation site [posttranslational modification] 1129794002348 intermolecular recognition site; other site 1129794002349 dimerization interface [polypeptide binding]; other site 1129794002350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794002351 DNA binding site [nucleotide binding] 1129794002352 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1129794002353 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1129794002354 PAS domain; Region: PAS; smart00091 1129794002355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794002356 dimer interface [polypeptide binding]; other site 1129794002357 phosphorylation site [posttranslational modification] 1129794002358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794002359 ATP binding site [chemical binding]; other site 1129794002360 Mg2+ binding site [ion binding]; other site 1129794002361 G-X-G motif; other site 1129794002362 Beta-lactamase; Region: Beta-lactamase; cl17358 1129794002363 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 1129794002364 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794002365 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794002366 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 1129794002367 active site 1129794002368 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1129794002369 nudix motif; other site 1129794002370 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1129794002371 active site 1129794002372 GDP-Mannose binding site [chemical binding]; other site 1129794002373 dimer interface [polypeptide binding]; other site 1129794002374 modified nudix motif 1129794002375 metal binding site [ion binding]; metal-binding site 1129794002376 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794002377 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794002378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794002379 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1129794002380 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1129794002381 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1129794002382 active site 1129794002383 metal binding site [ion binding]; metal-binding site 1129794002384 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1129794002385 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1129794002386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794002387 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1129794002388 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1129794002389 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1129794002390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794002391 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1129794002392 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1129794002393 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1129794002394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794002395 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1129794002396 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794002397 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1129794002398 putative acyl transferase; Provisional; Region: PRK10502 1129794002399 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1129794002400 putative trimer interface [polypeptide binding]; other site 1129794002401 putative active site [active] 1129794002402 putative substrate binding site [chemical binding]; other site 1129794002403 putative CoA binding site [chemical binding]; other site 1129794002404 putative glycosyl transferase; Provisional; Region: PRK10307 1129794002405 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1129794002406 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1129794002407 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1129794002408 NADP-binding site; other site 1129794002409 homotetramer interface [polypeptide binding]; other site 1129794002410 substrate binding site [chemical binding]; other site 1129794002411 homodimer interface [polypeptide binding]; other site 1129794002412 active site 1129794002413 GxxExxY protein; Region: GxxExxY; TIGR04256 1129794002414 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1129794002415 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1129794002416 NADP binding site [chemical binding]; other site 1129794002417 active site 1129794002418 putative substrate binding site [chemical binding]; other site 1129794002419 Integrase core domain; Region: rve; pfam00665 1129794002420 BCCT family transporter; Region: BCCT; cl00569 1129794002421 choline dehydrogenase; Validated; Region: PRK02106 1129794002422 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1129794002423 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1129794002424 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1129794002425 tetrameric interface [polypeptide binding]; other site 1129794002426 NAD binding site [chemical binding]; other site 1129794002427 catalytic residues [active] 1129794002428 Cadherin repeat-like domain; Region: CA_like; cl15786 1129794002429 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1129794002430 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794002431 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794002432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794002433 metal binding site [ion binding]; metal-binding site 1129794002434 active site 1129794002435 I-site; other site 1129794002436 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794002437 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794002438 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794002439 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1129794002440 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1129794002441 tetramer interface [polypeptide binding]; other site 1129794002442 TPP-binding site [chemical binding]; other site 1129794002443 heterodimer interface [polypeptide binding]; other site 1129794002444 phosphorylation loop region [posttranslational modification] 1129794002445 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1129794002446 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1129794002447 alpha subunit interface [polypeptide binding]; other site 1129794002448 TPP binding site [chemical binding]; other site 1129794002449 heterodimer interface [polypeptide binding]; other site 1129794002450 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1129794002451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794002452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794002453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1129794002454 dimerization interface [polypeptide binding]; other site 1129794002455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1129794002456 gamma-glutamyl kinase; Provisional; Region: PRK05429 1129794002457 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1129794002458 nucleotide binding site [chemical binding]; other site 1129794002459 homotetrameric interface [polypeptide binding]; other site 1129794002460 putative phosphate binding site [ion binding]; other site 1129794002461 putative allosteric binding site; other site 1129794002462 PUA domain; Region: PUA; pfam01472 1129794002463 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1129794002464 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1129794002465 cobalamin binding residues [chemical binding]; other site 1129794002466 putative BtuC binding residues; other site 1129794002467 dimer interface [polypeptide binding]; other site 1129794002468 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1129794002469 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1129794002470 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1129794002471 homodimer interface [polypeptide binding]; other site 1129794002472 Walker A motif; other site 1129794002473 ATP binding site [chemical binding]; other site 1129794002474 hydroxycobalamin binding site [chemical binding]; other site 1129794002475 Walker B motif; other site 1129794002476 cobyric acid synthase; Provisional; Region: PRK00784 1129794002477 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1129794002478 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1129794002479 catalytic triad [active] 1129794002480 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1129794002481 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1129794002482 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1129794002483 homotrimer interface [polypeptide binding]; other site 1129794002484 Walker A motif; other site 1129794002485 GTP binding site [chemical binding]; other site 1129794002486 Walker B motif; other site 1129794002487 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1129794002488 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1129794002489 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1129794002490 putative dimer interface [polypeptide binding]; other site 1129794002491 active site pocket [active] 1129794002492 putative cataytic base [active] 1129794002493 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1129794002494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1129794002495 ABC-ATPase subunit interface; other site 1129794002496 dimer interface [polypeptide binding]; other site 1129794002497 putative PBP binding regions; other site 1129794002498 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1129794002499 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1129794002500 Walker A/P-loop; other site 1129794002501 ATP binding site [chemical binding]; other site 1129794002502 Q-loop/lid; other site 1129794002503 ABC transporter signature motif; other site 1129794002504 Walker B; other site 1129794002505 D-loop; other site 1129794002506 H-loop/switch region; other site 1129794002507 exonuclease subunit SbcD; Provisional; Region: PRK10966 1129794002508 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1129794002509 active site 1129794002510 metal binding site [ion binding]; metal-binding site 1129794002511 DNA binding site [nucleotide binding] 1129794002512 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1129794002513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794002514 AAA domain; Region: AAA_23; pfam13476 1129794002515 Walker A/P-loop; other site 1129794002516 ATP binding site [chemical binding]; other site 1129794002517 Q-loop/lid; other site 1129794002518 exonuclease subunit SbcC; Provisional; Region: PRK10246 1129794002519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794002520 ABC transporter signature motif; other site 1129794002521 Walker B; other site 1129794002522 D-loop; other site 1129794002523 H-loop/switch region; other site 1129794002524 Integrase core domain; Region: rve; pfam00665 1129794002525 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1129794002526 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1129794002527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794002528 FeS/SAM binding site; other site 1129794002529 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1129794002530 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794002531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794002532 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794002533 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794002534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794002535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794002536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794002537 glutamate dehydrogenase; Provisional; Region: PRK09414 1129794002538 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1129794002539 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1129794002540 NAD(P) binding site [chemical binding]; other site 1129794002541 Domain of unknown function (DUF2431); Region: DUF2431; pfam10354 1129794002542 RecX family; Region: RecX; pfam02631 1129794002543 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1129794002544 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1129794002545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794002546 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1129794002547 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1129794002548 PA14 domain; Region: PA14; cl08459 1129794002549 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1129794002550 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794002551 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794002552 N-terminal plug; other site 1129794002553 ligand-binding site [chemical binding]; other site 1129794002554 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794002555 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1129794002556 Sulfatase; Region: Sulfatase; pfam00884 1129794002557 SnoaL-like domain; Region: SnoaL_4; pfam13577 1129794002558 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1129794002559 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1129794002560 Part of AAA domain; Region: AAA_19; pfam13245 1129794002561 Family description; Region: UvrD_C_2; pfam13538 1129794002562 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1129794002563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794002564 putative substrate translocation pore; other site 1129794002565 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1129794002566 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794002567 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794002568 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1129794002569 MarR family; Region: MarR_2; pfam12802 1129794002570 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1129794002571 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1129794002572 RNA/DNA hybrid binding site [nucleotide binding]; other site 1129794002573 active site 1129794002574 Transposase IS200 like; Region: Y1_Tnp; cl00848 1129794002575 Class I aldolases; Region: Aldolase_Class_I; cl17187 1129794002576 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1129794002577 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1129794002578 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1129794002579 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1129794002580 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1129794002581 N- and C-terminal domain interface [polypeptide binding]; other site 1129794002582 active site 1129794002583 MgATP binding site [chemical binding]; other site 1129794002584 catalytic site [active] 1129794002585 metal binding site [ion binding]; metal-binding site 1129794002586 glycerol binding site [chemical binding]; other site 1129794002587 homotetramer interface [polypeptide binding]; other site 1129794002588 homodimer interface [polypeptide binding]; other site 1129794002589 FBP binding site [chemical binding]; other site 1129794002590 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1129794002591 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1129794002592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794002593 Walker A/P-loop; other site 1129794002594 ATP binding site [chemical binding]; other site 1129794002595 Q-loop/lid; other site 1129794002596 ABC transporter signature motif; other site 1129794002597 Walker B; other site 1129794002598 D-loop; other site 1129794002599 H-loop/switch region; other site 1129794002600 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1129794002601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794002602 Walker A motif; other site 1129794002603 ATP binding site [chemical binding]; other site 1129794002604 Walker B motif; other site 1129794002605 arginine finger; other site 1129794002606 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1129794002607 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1129794002608 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1129794002609 Walker A/P-loop; other site 1129794002610 ATP binding site [chemical binding]; other site 1129794002611 Q-loop/lid; other site 1129794002612 ABC transporter signature motif; other site 1129794002613 Walker B; other site 1129794002614 D-loop; other site 1129794002615 H-loop/switch region; other site 1129794002616 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1129794002617 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1129794002618 Walker A/P-loop; other site 1129794002619 ATP binding site [chemical binding]; other site 1129794002620 Q-loop/lid; other site 1129794002621 ABC transporter signature motif; other site 1129794002622 Walker B; other site 1129794002623 D-loop; other site 1129794002624 H-loop/switch region; other site 1129794002625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794002626 dimer interface [polypeptide binding]; other site 1129794002627 conserved gate region; other site 1129794002628 putative PBP binding loops; other site 1129794002629 ABC-ATPase subunit interface; other site 1129794002630 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1129794002631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794002632 dimer interface [polypeptide binding]; other site 1129794002633 conserved gate region; other site 1129794002634 putative PBP binding loops; other site 1129794002635 ABC-ATPase subunit interface; other site 1129794002636 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1129794002637 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1129794002638 Gram-negative porin; Region: Porin_4; pfam13609 1129794002639 Nitrate and nitrite sensing; Region: NIT; pfam08376 1129794002640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1129794002641 dimerization interface [polypeptide binding]; other site 1129794002642 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1129794002643 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794002644 dimer interface [polypeptide binding]; other site 1129794002645 putative CheW interface [polypeptide binding]; other site 1129794002646 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 1129794002647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794002648 active site 1129794002649 phosphorylation site [posttranslational modification] 1129794002650 intermolecular recognition site; other site 1129794002651 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1129794002652 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794002653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794002654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794002655 ATP binding site [chemical binding]; other site 1129794002656 Mg2+ binding site [ion binding]; other site 1129794002657 G-X-G motif; other site 1129794002658 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1129794002659 Carbon starvation protein CstA; Region: CstA; pfam02554 1129794002660 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1129794002661 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1129794002662 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1129794002663 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1129794002664 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1129794002665 putative metal binding site [ion binding]; other site 1129794002666 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794002667 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794002668 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794002669 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794002670 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1129794002671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1129794002672 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794002673 binding surface 1129794002674 TPR motif; other site 1129794002675 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 1129794002676 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1129794002677 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1129794002678 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1129794002679 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1129794002680 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1129794002681 dimer interface [polypeptide binding]; other site 1129794002682 active site 1129794002683 metal binding site [ion binding]; metal-binding site 1129794002684 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1129794002685 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1129794002686 NAD(P) binding site [chemical binding]; other site 1129794002687 substrate binding site [chemical binding]; other site 1129794002688 dimer interface [polypeptide binding]; other site 1129794002689 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1129794002690 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794002691 putative C-terminal domain interface [polypeptide binding]; other site 1129794002692 putative GSH binding site (G-site) [chemical binding]; other site 1129794002693 putative dimer interface [polypeptide binding]; other site 1129794002694 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794002695 N-terminal domain interface [polypeptide binding]; other site 1129794002696 dimer interface [polypeptide binding]; other site 1129794002697 substrate binding pocket (H-site) [chemical binding]; other site 1129794002698 DNA-J related protein; Region: DNAJ_related; pfam12339 1129794002699 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1129794002700 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1129794002701 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1129794002702 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1129794002703 DNA topoisomerase III; Provisional; Region: PRK07726 1129794002704 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1129794002705 active site 1129794002706 putative interdomain interaction site [polypeptide binding]; other site 1129794002707 putative metal-binding site [ion binding]; other site 1129794002708 putative nucleotide binding site [chemical binding]; other site 1129794002709 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1129794002710 domain I; other site 1129794002711 DNA binding groove [nucleotide binding] 1129794002712 phosphate binding site [ion binding]; other site 1129794002713 domain II; other site 1129794002714 domain III; other site 1129794002715 nucleotide binding site [chemical binding]; other site 1129794002716 catalytic site [active] 1129794002717 domain IV; other site 1129794002718 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 1129794002719 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1129794002720 NADP binding site [chemical binding]; other site 1129794002721 dimer interface [polypeptide binding]; other site 1129794002722 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1129794002723 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1129794002724 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794002725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794002726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794002727 putative substrate translocation pore; other site 1129794002728 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1129794002729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794002730 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1129794002731 putative substrate translocation pore; other site 1129794002732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794002733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1129794002734 putative DNA binding site [nucleotide binding]; other site 1129794002735 putative Zn2+ binding site [ion binding]; other site 1129794002736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794002737 dimerization interface [polypeptide binding]; other site 1129794002738 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794002739 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 1129794002740 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1129794002741 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1129794002742 DNA-binding site [nucleotide binding]; DNA binding site 1129794002743 RNA-binding motif; other site 1129794002744 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1129794002745 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1129794002746 nucleotide binding site [chemical binding]; other site 1129794002747 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1129794002748 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1129794002749 nucleotide binding site [chemical binding]; other site 1129794002750 SBD interface [polypeptide binding]; other site 1129794002751 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794002752 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794002753 catalytic residue [active] 1129794002754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794002755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794002756 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1129794002757 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794002758 catalytic loop [active] 1129794002759 iron binding site [ion binding]; other site 1129794002760 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1129794002761 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1129794002762 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794002763 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1129794002764 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794002765 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794002766 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1129794002767 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1129794002768 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1129794002769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794002770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794002771 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1129794002772 putative efflux protein, MATE family; Region: matE; TIGR00797 1129794002773 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794002774 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1129794002775 C-terminal domain interface [polypeptide binding]; other site 1129794002776 GSH binding site (G-site) [chemical binding]; other site 1129794002777 dimer interface [polypeptide binding]; other site 1129794002778 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794002779 N-terminal domain interface [polypeptide binding]; other site 1129794002780 short chain dehydrogenase; Provisional; Region: PRK06197 1129794002781 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1129794002782 putative NAD(P) binding site [chemical binding]; other site 1129794002783 active site 1129794002784 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1129794002785 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1129794002786 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1129794002787 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794002788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794002789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1129794002790 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1129794002791 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1129794002792 heme binding site [chemical binding]; other site 1129794002793 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1129794002794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1129794002795 ACT domain; Region: ACT_3; pfam10000 1129794002796 Family description; Region: ACT_7; pfam13840 1129794002797 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1129794002798 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1129794002799 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 1129794002800 putative active site [active] 1129794002801 Zn binding site [ion binding]; other site 1129794002802 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794002803 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794002804 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794002805 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1129794002806 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1129794002807 Catalytic site [active] 1129794002808 short chain dehydrogenase; Provisional; Region: PRK06179 1129794002809 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1129794002810 NADP binding site [chemical binding]; other site 1129794002811 active site 1129794002812 steroid binding site; other site 1129794002813 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1129794002814 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1129794002815 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1129794002816 30S subunit binding site; other site 1129794002817 Ecdysteroid kinase; Region: EcKinase; cl17738 1129794002818 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 1129794002819 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1129794002820 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1129794002821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794002822 Walker A/P-loop; other site 1129794002823 ATP binding site [chemical binding]; other site 1129794002824 Q-loop/lid; other site 1129794002825 ABC transporter signature motif; other site 1129794002826 Walker B; other site 1129794002827 D-loop; other site 1129794002828 H-loop/switch region; other site 1129794002829 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1129794002830 active site 1129794002831 catalytic residues [active] 1129794002832 metal binding site [ion binding]; metal-binding site 1129794002833 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1129794002834 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794002835 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1129794002836 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1129794002837 hypothetical protein; Provisional; Region: PRK01254 1129794002838 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1129794002839 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1129794002840 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1129794002841 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1129794002842 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1129794002843 oligomer interface [polypeptide binding]; other site 1129794002844 metal binding site [ion binding]; metal-binding site 1129794002845 metal binding site [ion binding]; metal-binding site 1129794002846 Cl binding site [ion binding]; other site 1129794002847 aspartate ring; other site 1129794002848 basic sphincter; other site 1129794002849 putative hydrophobic gate; other site 1129794002850 periplasmic entrance; other site 1129794002851 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1129794002852 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1129794002853 active site 1129794002854 substrate-binding site [chemical binding]; other site 1129794002855 metal-binding site [ion binding] 1129794002856 ATP binding site [chemical binding]; other site 1129794002857 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1129794002858 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1129794002859 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1129794002860 active site 1129794002861 catalytic residues [active] 1129794002862 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1129794002863 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1129794002864 active site 1129794002865 catalytic residues [active] 1129794002866 S-layer homology domain; Region: SLH; pfam00395 1129794002867 Predicted ATPase [General function prediction only]; Region: COG1485 1129794002868 Putative transposase; Region: Y2_Tnp; pfam04986 1129794002869 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1129794002870 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1129794002871 active site 1129794002872 catalytic residues [active] 1129794002873 S-layer homology domain; Region: SLH; pfam00395 1129794002874 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1129794002875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794002876 dimerization interface [polypeptide binding]; other site 1129794002877 DNA binding residues [nucleotide binding] 1129794002878 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794002879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794002880 active site 1129794002881 phosphorylation site [posttranslational modification] 1129794002882 intermolecular recognition site; other site 1129794002883 dimerization interface [polypeptide binding]; other site 1129794002884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1129794002885 Histidine kinase; Region: HisKA_3; pfam07730 1129794002886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794002887 ATP binding site [chemical binding]; other site 1129794002888 Mg2+ binding site [ion binding]; other site 1129794002889 G-X-G motif; other site 1129794002890 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1129794002891 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1129794002892 active site 1129794002893 ATP binding site [chemical binding]; other site 1129794002894 substrate binding site [chemical binding]; other site 1129794002895 activation loop (A-loop); other site 1129794002896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794002897 binding surface 1129794002898 TPR motif; other site 1129794002899 TPR repeat; Region: TPR_11; pfam13414 1129794002900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794002901 binding surface 1129794002902 TPR motif; other site 1129794002903 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1129794002904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794002905 TPR motif; other site 1129794002906 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1129794002907 binding surface 1129794002908 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1129794002909 phosphopeptide binding site; other site 1129794002910 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1129794002911 GAF domain; Region: GAF; pfam01590 1129794002912 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794002913 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794002914 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1129794002915 dinuclear metal binding motif [ion binding]; other site 1129794002916 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 1129794002917 active site 1129794002918 RNA/DNA hybrid binding site [nucleotide binding]; other site 1129794002919 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1129794002920 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1129794002921 potential catalytic triad [active] 1129794002922 conserved cys residue [active] 1129794002923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794002924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794002925 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1129794002926 putative effector binding pocket; other site 1129794002927 dimerization interface [polypeptide binding]; other site 1129794002928 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1129794002929 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1129794002930 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 1129794002931 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1129794002932 Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434 1129794002933 substrate binding site [chemical binding]; other site 1129794002934 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1129794002935 substrate binding site [chemical binding]; other site 1129794002936 ligand binding site [chemical binding]; other site 1129794002937 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1129794002938 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1129794002939 substrate binding site [chemical binding]; other site 1129794002940 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1129794002941 substrate binding site [chemical binding]; other site 1129794002942 ligand binding site [chemical binding]; other site 1129794002943 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1129794002944 aspartate kinase III; Validated; Region: PRK09084 1129794002945 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 1129794002946 nucleotide binding site [chemical binding]; other site 1129794002947 putative catalytic residues [active] 1129794002948 aspartate binding site [chemical binding]; other site 1129794002949 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 1129794002950 lysine allosteric regulatory site; other site 1129794002951 dimer interface [polypeptide binding]; other site 1129794002952 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1129794002953 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794002954 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1129794002955 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1129794002956 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1129794002957 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1129794002958 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1129794002959 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1129794002960 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794002961 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1129794002962 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1129794002963 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794002964 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 1129794002965 OmpW family; Region: OmpW; cl17427 1129794002966 OmpW family; Region: OmpW; cl17427 1129794002967 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794002968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794002969 active site 1129794002970 phosphorylation site [posttranslational modification] 1129794002971 intermolecular recognition site; other site 1129794002972 dimerization interface [polypeptide binding]; other site 1129794002973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794002974 DNA binding site [nucleotide binding] 1129794002975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794002976 ATP binding site [chemical binding]; other site 1129794002977 Mg2+ binding site [ion binding]; other site 1129794002978 G-X-G motif; other site 1129794002979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794002980 dimer interface [polypeptide binding]; other site 1129794002981 phosphorylation site [posttranslational modification] 1129794002982 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1129794002983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794002984 TPR motif; other site 1129794002985 binding surface 1129794002986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794002987 binding surface 1129794002988 TPR motif; other site 1129794002989 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1129794002990 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794002991 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794002992 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794002993 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794002994 BCCT family transporter; Region: BCCT; cl00569 1129794002995 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1129794002996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794002997 catalytic residue [active] 1129794002998 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1129794002999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794003000 DNA-binding site [nucleotide binding]; DNA binding site 1129794003001 FCD domain; Region: FCD; pfam07729 1129794003002 Benzoate membrane transport protein; Region: BenE; pfam03594 1129794003003 benzoate transporter; Region: benE; TIGR00843 1129794003004 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1129794003005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1129794003006 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1129794003007 Sodium Bile acid symporter family; Region: SBF; cl17470 1129794003008 short chain dehydrogenase; Provisional; Region: PRK08251 1129794003009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794003010 NAD(P) binding site [chemical binding]; other site 1129794003011 active site 1129794003012 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1129794003013 catalytic core [active] 1129794003014 Phosphotransferase enzyme family; Region: APH; pfam01636 1129794003015 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1129794003016 putative active site [active] 1129794003017 putative substrate binding site [chemical binding]; other site 1129794003018 ATP binding site [chemical binding]; other site 1129794003019 short chain dehydrogenase; Provisional; Region: PRK05650 1129794003020 classical (c) SDRs; Region: SDR_c; cd05233 1129794003021 NAD(P) binding site [chemical binding]; other site 1129794003022 active site 1129794003023 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1129794003024 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794003025 active site 1129794003026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794003027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794003028 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1129794003029 substrate binding pocket [chemical binding]; other site 1129794003030 dimerization interface [polypeptide binding]; other site 1129794003031 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794003032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794003033 metal binding site [ion binding]; metal-binding site 1129794003034 active site 1129794003035 I-site; other site 1129794003036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794003037 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1129794003038 active site 1129794003039 GAT domain; Region: GAT; pfam03127 1129794003040 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794003041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794003042 metal binding site [ion binding]; metal-binding site 1129794003043 active site 1129794003044 I-site; other site 1129794003045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794003046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794003047 I-site; other site 1129794003048 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1129794003049 active site 1129794003050 metal binding site [ion binding]; metal-binding site 1129794003051 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1129794003052 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1129794003053 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1129794003054 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1129794003055 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1129794003056 lipoprotein signal peptidase; Provisional; Region: PRK14787 1129794003057 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1129794003058 HopJ type III effector protein; Region: HopJ; pfam08888 1129794003059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794003060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794003061 dimerization interface [polypeptide binding]; other site 1129794003062 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794003063 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1129794003064 putative C-terminal domain interface [polypeptide binding]; other site 1129794003065 putative GSH binding site (G-site) [chemical binding]; other site 1129794003066 putative dimer interface [polypeptide binding]; other site 1129794003067 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794003068 dimer interface [polypeptide binding]; other site 1129794003069 substrate binding pocket (H-site) [chemical binding]; other site 1129794003070 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794003071 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1129794003072 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794003073 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794003074 catalytic residue [active] 1129794003075 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794003076 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794003077 N-terminal plug; other site 1129794003078 ligand-binding site [chemical binding]; other site 1129794003079 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1129794003080 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1129794003081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794003082 PAS fold; Region: PAS_3; pfam08447 1129794003083 putative active site [active] 1129794003084 heme pocket [chemical binding]; other site 1129794003085 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1129794003086 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1129794003087 G1 box; other site 1129794003088 putative GEF interaction site [polypeptide binding]; other site 1129794003089 GTP/Mg2+ binding site [chemical binding]; other site 1129794003090 Switch I region; other site 1129794003091 G2 box; other site 1129794003092 G3 box; other site 1129794003093 Switch II region; other site 1129794003094 G4 box; other site 1129794003095 G5 box; other site 1129794003096 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1129794003097 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1129794003098 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1129794003099 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1129794003100 G1 box; other site 1129794003101 putative GEF interaction site [polypeptide binding]; other site 1129794003102 GTP/Mg2+ binding site [chemical binding]; other site 1129794003103 Switch I region; other site 1129794003104 G2 box; other site 1129794003105 G3 box; other site 1129794003106 Switch II region; other site 1129794003107 G4 box; other site 1129794003108 G5 box; other site 1129794003109 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1129794003110 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1129794003111 glutamine synthetase; Provisional; Region: glnA; PRK09469 1129794003112 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1129794003113 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1129794003114 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1129794003115 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1129794003116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794003117 putative active site [active] 1129794003118 heme pocket [chemical binding]; other site 1129794003119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794003120 dimer interface [polypeptide binding]; other site 1129794003121 phosphorylation site [posttranslational modification] 1129794003122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794003123 ATP binding site [chemical binding]; other site 1129794003124 Mg2+ binding site [ion binding]; other site 1129794003125 G-X-G motif; other site 1129794003126 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1129794003127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794003128 active site 1129794003129 phosphorylation site [posttranslational modification] 1129794003130 intermolecular recognition site; other site 1129794003131 dimerization interface [polypeptide binding]; other site 1129794003132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794003133 Walker A motif; other site 1129794003134 ATP binding site [chemical binding]; other site 1129794003135 Walker B motif; other site 1129794003136 arginine finger; other site 1129794003137 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1129794003138 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1129794003139 putative binding surface; other site 1129794003140 active site 1129794003141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794003142 Zn2+ binding site [ion binding]; other site 1129794003143 Mg2+ binding site [ion binding]; other site 1129794003144 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1129794003145 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1129794003146 putative acyl-acceptor binding pocket; other site 1129794003147 RNase E inhibitor protein; Provisional; Region: PRK11191 1129794003148 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1129794003149 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794003150 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794003151 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1129794003152 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1129794003153 putative active site [active] 1129794003154 putative metal binding site [ion binding]; other site 1129794003155 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1129794003156 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1129794003157 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1129794003158 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1129794003159 putative trimer interface [polypeptide binding]; other site 1129794003160 putative CoA binding site [chemical binding]; other site 1129794003161 Family description; Region: VCBS; pfam13517 1129794003162 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 1129794003163 ATP binding site [chemical binding]; other site 1129794003164 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794003165 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794003166 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794003167 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794003168 N-terminal plug; other site 1129794003169 ligand-binding site [chemical binding]; other site 1129794003170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794003171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794003172 Putative transposase; Region: Y2_Tnp; pfam04986 1129794003173 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794003174 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1129794003175 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1129794003176 catalytic residues [active] 1129794003177 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1129794003178 catalytic motif [active] 1129794003179 Catalytic residue [active] 1129794003180 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1129794003181 active site 1129794003182 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 1129794003183 putative ligand binding site [chemical binding]; other site 1129794003184 Protein of unknown function, DUF462; Region: DUF462; pfam04315 1129794003185 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1129794003186 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1129794003187 YfcL protein; Region: YfcL; pfam08891 1129794003188 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 1129794003189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794003190 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1129794003191 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1129794003192 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1129794003193 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1129794003194 dimer interface [polypeptide binding]; other site 1129794003195 active site 1129794003196 Protein of unknown function (DUF952); Region: DUF952; cl01393 1129794003197 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1129794003198 HSP70 interaction site [polypeptide binding]; other site 1129794003199 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1129794003200 Predicted membrane protein [Function unknown]; Region: COG2311 1129794003201 Protein of unknown function (DUF418); Region: DUF418; cl12135 1129794003202 short chain dehydrogenase; Provisional; Region: PRK07576 1129794003203 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1129794003204 NAD(P) binding site [chemical binding]; other site 1129794003205 substrate binding site [chemical binding]; other site 1129794003206 homotetramer interface [polypeptide binding]; other site 1129794003207 active site 1129794003208 homodimer interface [polypeptide binding]; other site 1129794003209 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794003210 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794003211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794003212 Homeodomain-like domain; Region: HTH_23; pfam13384 1129794003213 Winged helix-turn helix; Region: HTH_29; pfam13551 1129794003214 Winged helix-turn helix; Region: HTH_33; pfam13592 1129794003215 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1129794003216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1129794003217 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1129794003218 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1129794003219 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1129794003220 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794003221 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794003222 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1129794003223 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1129794003224 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794003225 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 1129794003226 Ribosome recycling factor; Region: RRF_GI; pfam12614 1129794003227 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1129794003228 hydrophobic ligand binding site; other site 1129794003229 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1129794003230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794003231 NAD(P) binding site [chemical binding]; other site 1129794003232 active site 1129794003233 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794003234 acyl-activating enzyme (AAE) consensus motif; other site 1129794003235 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794003236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794003237 CoA binding site [chemical binding]; other site 1129794003238 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1129794003239 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794003240 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1129794003241 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1129794003242 TrkA-N domain; Region: TrkA_N; pfam02254 1129794003243 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1129794003244 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1129794003245 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1129794003246 ligand binding site [chemical binding]; other site 1129794003247 flexible hinge region; other site 1129794003248 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1129794003249 aldolase II superfamily protein; Provisional; Region: PRK07044 1129794003250 intersubunit interface [polypeptide binding]; other site 1129794003251 active site 1129794003252 Zn2+ binding site [ion binding]; other site 1129794003253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794003254 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 1129794003255 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1129794003256 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1129794003257 ligand binding site [chemical binding]; other site 1129794003258 NAD binding site [chemical binding]; other site 1129794003259 catalytic site [active] 1129794003260 homodimer interface [polypeptide binding]; other site 1129794003261 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1129794003262 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1129794003263 FimV N-terminal domain; Region: FimV_core; TIGR03505 1129794003264 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1129794003265 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1129794003266 conserved cys residue [active] 1129794003267 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1129794003268 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1129794003269 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1129794003270 conserved cys residue [active] 1129794003271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794003272 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794003273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794003274 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1129794003275 putative dimerization interface [polypeptide binding]; other site 1129794003276 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794003277 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794003278 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794003279 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1129794003280 Predicted membrane protein [Function unknown]; Region: COG1288 1129794003281 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1129794003282 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1129794003283 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1129794003284 HDOD domain; Region: HDOD; pfam08668 1129794003285 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1129794003286 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1129794003287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794003288 PGAP1-like protein; Region: PGAP1; pfam07819 1129794003289 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794003290 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1129794003291 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1129794003292 classical (c) SDRs; Region: SDR_c; cd05233 1129794003293 NAD(P) binding site [chemical binding]; other site 1129794003294 active site 1129794003295 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1129794003296 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1129794003297 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1129794003298 active site 1129794003299 Zn binding site [ion binding]; other site 1129794003300 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1129794003301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1129794003302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1129794003303 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1129794003304 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1129794003305 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1129794003306 E3 interaction surface; other site 1129794003307 lipoyl attachment site [posttranslational modification]; other site 1129794003308 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1129794003309 E3 interaction surface; other site 1129794003310 lipoyl attachment site [posttranslational modification]; other site 1129794003311 e3 binding domain; Region: E3_binding; pfam02817 1129794003312 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1129794003313 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1129794003314 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1129794003315 dimer interface [polypeptide binding]; other site 1129794003316 TPP-binding site [chemical binding]; other site 1129794003317 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1129794003318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794003319 DNA-binding site [nucleotide binding]; DNA binding site 1129794003320 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1129794003321 regulatory protein AmpE; Provisional; Region: PRK10987 1129794003322 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1129794003323 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1129794003324 amidase catalytic site [active] 1129794003325 Zn binding residues [ion binding]; other site 1129794003326 substrate binding site [chemical binding]; other site 1129794003327 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1129794003328 catalytic motif [active] 1129794003329 Catalytic residue [active] 1129794003330 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1129794003331 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1129794003332 dimerization interface [polypeptide binding]; other site 1129794003333 active site 1129794003334 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1129794003335 putative major pilin subunit; Provisional; Region: PRK10574 1129794003336 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1129794003337 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1129794003338 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1129794003339 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1129794003340 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1129794003341 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1129794003342 dephospho-CoA kinase; Region: TIGR00152 1129794003343 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1129794003344 CoA-binding site [chemical binding]; other site 1129794003345 hypothetical protein; Provisional; Region: PRK05287 1129794003346 Domain of unknown function (DUF329); Region: DUF329; cl01144 1129794003347 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1129794003348 catalytic triad [active] 1129794003349 dimer interface [polypeptide binding]; other site 1129794003350 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794003351 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1129794003352 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 1129794003353 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794003354 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794003355 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1129794003356 catalytic residues [active] 1129794003357 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1129794003358 putative efflux protein, MATE family; Region: matE; TIGR00797 1129794003359 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1129794003360 homotrimer interaction site [polypeptide binding]; other site 1129794003361 putative active site [active] 1129794003362 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794003363 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1129794003364 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1129794003365 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794003366 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794003367 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1129794003368 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794003369 catalytic loop [active] 1129794003370 iron binding site [ion binding]; other site 1129794003371 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1129794003372 short chain dehydrogenase; Provisional; Region: PRK06172 1129794003373 classical (c) SDRs; Region: SDR_c; cd05233 1129794003374 NAD(P) binding site [chemical binding]; other site 1129794003375 active site 1129794003376 methionine gamma-lyase; Validated; Region: PRK07049 1129794003377 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1129794003378 homodimer interface [polypeptide binding]; other site 1129794003379 substrate-cofactor binding pocket; other site 1129794003380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794003381 catalytic residue [active] 1129794003382 hypothetical protein; Provisional; Region: PRK11239 1129794003383 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1129794003384 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1129794003385 ABC1 family; Region: ABC1; cl17513 1129794003386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1129794003387 MarR family; Region: MarR; pfam01047 1129794003388 MarR family; Region: MarR_2; cl17246 1129794003389 gamma-glutamyl kinase; Provisional; Region: PRK13402 1129794003390 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1129794003391 nucleotide binding site [chemical binding]; other site 1129794003392 homotetrameric interface [polypeptide binding]; other site 1129794003393 putative phosphate binding site [ion binding]; other site 1129794003394 putative allosteric binding site; other site 1129794003395 PUA domain; Region: PUA; cl00607 1129794003396 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1129794003397 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1129794003398 putative catalytic cysteine [active] 1129794003399 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1129794003400 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 1129794003401 Peptidase family M28; Region: Peptidase_M28; pfam04389 1129794003402 putative metal binding site [ion binding]; other site 1129794003403 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1129794003404 Interdomain contacts; other site 1129794003405 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1129794003406 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1129794003407 putative active site [active] 1129794003408 Zn binding site [ion binding]; other site 1129794003409 WYL domain; Region: WYL; pfam13280 1129794003410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1129794003411 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1129794003412 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1129794003413 ligand binding site [chemical binding]; other site 1129794003414 NAD binding site [chemical binding]; other site 1129794003415 tetramer interface [polypeptide binding]; other site 1129794003416 catalytic site [active] 1129794003417 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1129794003418 L-serine binding site [chemical binding]; other site 1129794003419 ACT domain interface; other site 1129794003420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794003421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794003422 ATP binding site [chemical binding]; other site 1129794003423 Mg2+ binding site [ion binding]; other site 1129794003424 G-X-G motif; other site 1129794003425 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1129794003426 RNA methyltransferase, RsmE family; Region: TIGR00046 1129794003427 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794003428 Peptidase family M48; Region: Peptidase_M48; pfam01435 1129794003429 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1129794003430 FecR protein; Region: FecR; pfam04773 1129794003431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794003432 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1129794003433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794003434 DNA binding residues [nucleotide binding] 1129794003435 Secretin and TonB N terminus short domain; Region: STN; smart00965 1129794003436 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794003437 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794003438 N-terminal plug; other site 1129794003439 ligand-binding site [chemical binding]; other site 1129794003440 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1129794003441 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1129794003442 active site 1129794003443 putative substrate binding pocket [chemical binding]; other site 1129794003444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794003445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794003446 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1129794003447 substrate binding pocket [chemical binding]; other site 1129794003448 dimerization interface [polypeptide binding]; other site 1129794003449 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1129794003450 dimer interface [polypeptide binding]; other site 1129794003451 active site 1129794003452 glutathione binding site [chemical binding]; other site 1129794003453 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1129794003454 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1129794003455 FMN binding site [chemical binding]; other site 1129794003456 active site 1129794003457 substrate binding site [chemical binding]; other site 1129794003458 catalytic residue [active] 1129794003459 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794003460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794003461 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1129794003462 substrate binding pocket [chemical binding]; other site 1129794003463 dimerization interface [polypeptide binding]; other site 1129794003464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1129794003465 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1129794003466 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1129794003467 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1129794003468 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1129794003469 transketolase; Reviewed; Region: PRK12753 1129794003470 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1129794003471 TPP-binding site [chemical binding]; other site 1129794003472 dimer interface [polypeptide binding]; other site 1129794003473 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1129794003474 PYR/PP interface [polypeptide binding]; other site 1129794003475 dimer interface [polypeptide binding]; other site 1129794003476 TPP binding site [chemical binding]; other site 1129794003477 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1129794003478 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1129794003479 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1129794003480 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1129794003481 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1129794003482 Phosphoglycerate kinase; Region: PGK; pfam00162 1129794003483 substrate binding site [chemical binding]; other site 1129794003484 hinge regions; other site 1129794003485 ADP binding site [chemical binding]; other site 1129794003486 catalytic site [active] 1129794003487 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 1129794003488 catalytic residue [active] 1129794003489 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1129794003490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794003491 S-adenosylmethionine binding site [chemical binding]; other site 1129794003492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794003493 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1129794003494 FeS/SAM binding site; other site 1129794003495 exopolyphosphatase; Provisional; Region: PRK10854 1129794003496 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1129794003497 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 1129794003498 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1129794003499 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1129794003500 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 1129794003501 domain interface [polypeptide binding]; other site 1129794003502 active site 1129794003503 catalytic site [active] 1129794003504 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1129794003505 putative active site [active] 1129794003506 catalytic site [active] 1129794003507 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1129794003508 ACT domain; Region: ACT_6; pfam13740 1129794003509 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1129794003510 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1129794003511 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1129794003512 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1129794003513 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1129794003514 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1129794003515 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794003516 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794003517 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1129794003518 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 1129794003519 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 1129794003520 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1129794003521 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1129794003522 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1129794003523 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1129794003524 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1129794003525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794003526 binding surface 1129794003527 TPR motif; other site 1129794003528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794003529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794003530 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1129794003531 dimerization interface [polypeptide binding]; other site 1129794003532 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 1129794003533 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1129794003534 dimer interface [polypeptide binding]; other site 1129794003535 active site 1129794003536 CoA binding pocket [chemical binding]; other site 1129794003537 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 1129794003538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794003539 ATP binding site [chemical binding]; other site 1129794003540 Mg2+ binding site [ion binding]; other site 1129794003541 G-X-G motif; other site 1129794003542 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 1129794003543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794003544 active site 1129794003545 phosphorylation site [posttranslational modification] 1129794003546 intermolecular recognition site; other site 1129794003547 dimerization interface [polypeptide binding]; other site 1129794003548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794003549 Walker A motif; other site 1129794003550 ATP binding site [chemical binding]; other site 1129794003551 Walker B motif; other site 1129794003552 arginine finger; other site 1129794003553 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1129794003554 LrgA family; Region: LrgA; pfam03788 1129794003555 LrgB-like family; Region: LrgB; pfam04172 1129794003556 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1129794003557 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1129794003558 HemN family oxidoreductase; Provisional; Region: PRK05660 1129794003559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794003560 FeS/SAM binding site; other site 1129794003561 HemN C-terminal domain; Region: HemN_C; pfam06969 1129794003562 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1129794003563 active site 1129794003564 dimerization interface [polypeptide binding]; other site 1129794003565 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1129794003566 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1129794003567 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794003568 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1129794003569 ATP binding site [chemical binding]; other site 1129794003570 Mg++ binding site [ion binding]; other site 1129794003571 motif III; other site 1129794003572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794003573 nucleotide binding region [chemical binding]; other site 1129794003574 ATP-binding site [chemical binding]; other site 1129794003575 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1129794003576 UbiA prenyltransferase family; Region: UbiA; pfam01040 1129794003577 Predicted small integral membrane protein [Function unknown]; Region: COG5605 1129794003578 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 1129794003579 Subunit I/III interface [polypeptide binding]; other site 1129794003580 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1129794003581 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1129794003582 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1129794003583 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1129794003584 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1129794003585 Cytochrome c; Region: Cytochrom_C; cl11414 1129794003586 Cytochrome c; Region: Cytochrom_C; pfam00034 1129794003587 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1129794003588 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1129794003589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794003590 ATP binding site [chemical binding]; other site 1129794003591 putative Mg++ binding site [ion binding]; other site 1129794003592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794003593 nucleotide binding region [chemical binding]; other site 1129794003594 ATP-binding site [chemical binding]; other site 1129794003595 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794003596 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794003597 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794003598 FecR protein; Region: FecR; pfam04773 1129794003599 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1129794003600 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1129794003601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794003602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794003603 DNA binding residues [nucleotide binding] 1129794003604 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794003605 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794003606 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1129794003607 Fasciclin domain; Region: Fasciclin; pfam02469 1129794003608 LytTr DNA-binding domain; Region: LytTR; cl04498 1129794003609 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 1129794003610 active site 1129794003611 Ca binding site [ion binding]; other site 1129794003612 catalytic site [active] 1129794003613 Aamy_C domain; Region: Aamy_C; smart00632 1129794003614 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1129794003615 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794003616 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1129794003617 active site 1129794003618 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1129794003619 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794003620 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794003621 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794003622 dUTPase; Region: dUTPase_2; pfam08761 1129794003623 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1129794003624 active site 1129794003625 homodimer interface [polypeptide binding]; other site 1129794003626 metal binding site [ion binding]; metal-binding site 1129794003627 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1129794003628 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1129794003629 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1129794003630 active site 1129794003631 NTP binding site [chemical binding]; other site 1129794003632 metal binding triad [ion binding]; metal-binding site 1129794003633 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1129794003634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794003635 Zn2+ binding site [ion binding]; other site 1129794003636 Mg2+ binding site [ion binding]; other site 1129794003637 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1129794003638 AAA domain; Region: AAA_30; pfam13604 1129794003639 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1129794003640 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1129794003641 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1129794003642 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794003643 Zn2+ binding site [ion binding]; other site 1129794003644 Mg2+ binding site [ion binding]; other site 1129794003645 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1129794003646 active site 1129794003647 AAA domain; Region: AAA_17; cl17253 1129794003648 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1129794003649 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1129794003650 TrkA-N domain; Region: TrkA_N; pfam02254 1129794003651 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1129794003652 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 1129794003653 PA/protease or protease-like domain interface [polypeptide binding]; other site 1129794003654 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 1129794003655 Peptidase family M28; Region: Peptidase_M28; pfam04389 1129794003656 metal binding site [ion binding]; metal-binding site 1129794003657 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1129794003658 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1129794003659 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1129794003660 substrate binding site [chemical binding]; other site 1129794003661 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1129794003662 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1129794003663 substrate binding site [chemical binding]; other site 1129794003664 ligand binding site [chemical binding]; other site 1129794003665 tartrate dehydrogenase; Region: TTC; TIGR02089 1129794003666 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1129794003667 2-isopropylmalate synthase; Validated; Region: PRK00915 1129794003668 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1129794003669 active site 1129794003670 catalytic residues [active] 1129794003671 metal binding site [ion binding]; metal-binding site 1129794003672 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1129794003673 enolase; Provisional; Region: eno; PRK00077 1129794003674 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1129794003675 dimer interface [polypeptide binding]; other site 1129794003676 metal binding site [ion binding]; metal-binding site 1129794003677 substrate binding pocket [chemical binding]; other site 1129794003678 CTP synthetase; Validated; Region: pyrG; PRK05380 1129794003679 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1129794003680 Catalytic site [active] 1129794003681 active site 1129794003682 UTP binding site [chemical binding]; other site 1129794003683 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1129794003684 active site 1129794003685 putative oxyanion hole; other site 1129794003686 catalytic triad [active] 1129794003687 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1129794003688 MutS domain I; Region: MutS_I; pfam01624 1129794003689 MutS domain II; Region: MutS_II; pfam05188 1129794003690 MutS domain III; Region: MutS_III; pfam05192 1129794003691 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1129794003692 Walker A/P-loop; other site 1129794003693 ATP binding site [chemical binding]; other site 1129794003694 Q-loop/lid; other site 1129794003695 ABC transporter signature motif; other site 1129794003696 Walker B; other site 1129794003697 D-loop; other site 1129794003698 H-loop/switch region; other site 1129794003699 Competence-damaged protein; Region: CinA; cl00666 1129794003700 recombinase A; Provisional; Region: recA; PRK09354 1129794003701 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1129794003702 hexamer interface [polypeptide binding]; other site 1129794003703 Walker A motif; other site 1129794003704 ATP binding site [chemical binding]; other site 1129794003705 Walker B motif; other site 1129794003706 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794003707 dimer interface [polypeptide binding]; other site 1129794003708 putative CheW interface [polypeptide binding]; other site 1129794003709 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1129794003710 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1129794003711 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1129794003712 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1129794003713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794003714 Walker A/P-loop; other site 1129794003715 ATP binding site [chemical binding]; other site 1129794003716 Q-loop/lid; other site 1129794003717 ABC transporter signature motif; other site 1129794003718 Walker B; other site 1129794003719 D-loop; other site 1129794003720 H-loop/switch region; other site 1129794003721 heme exporter protein CcmB; Region: ccmB; TIGR01190 1129794003722 heme exporter protein CcmC; Region: ccmC; TIGR01191 1129794003723 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1129794003724 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1129794003725 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1129794003726 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794003727 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794003728 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1129794003729 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1129794003730 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1129794003731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794003732 binding surface 1129794003733 TPR motif; other site 1129794003734 VacJ like lipoprotein; Region: VacJ; cl01073 1129794003735 Protein of unknown function DUF86; Region: DUF86; pfam01934 1129794003736 Protein of unknown function DUF86; Region: DUF86; pfam01934 1129794003737 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1129794003738 active site 1129794003739 NTP binding site [chemical binding]; other site 1129794003740 metal binding triad [ion binding]; metal-binding site 1129794003741 antibiotic binding site [chemical binding]; other site 1129794003742 UDP-glucose 4-epimerase; Region: PLN02240 1129794003743 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1129794003744 NAD binding site [chemical binding]; other site 1129794003745 homodimer interface [polypeptide binding]; other site 1129794003746 active site 1129794003747 substrate binding site [chemical binding]; other site 1129794003748 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1129794003749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794003750 POT family; Region: PTR2; cl17359 1129794003751 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1129794003752 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1129794003753 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1129794003754 SLBB domain; Region: SLBB; pfam10531 1129794003755 Chain length determinant protein; Region: Wzz; pfam02706 1129794003756 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1129794003757 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794003758 active site 1129794003759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794003760 Cupin domain; Region: Cupin_2; cl17218 1129794003761 Cupin domain; Region: Cupin_2; cl17218 1129794003762 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1129794003763 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1129794003764 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1129794003765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1129794003766 UDP-galactopyranose mutase; Region: GLF; pfam03275 1129794003767 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794003768 active site 1129794003769 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1129794003770 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794003771 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1129794003772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794003773 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794003774 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1129794003775 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1129794003776 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1129794003777 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1129794003778 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1129794003779 substrate binding site; other site 1129794003780 tetramer interface; other site 1129794003781 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1129794003782 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1129794003783 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1129794003784 NADP binding site [chemical binding]; other site 1129794003785 active site 1129794003786 putative substrate binding site [chemical binding]; other site 1129794003787 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1129794003788 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1129794003789 NAD binding site [chemical binding]; other site 1129794003790 substrate binding site [chemical binding]; other site 1129794003791 homodimer interface [polypeptide binding]; other site 1129794003792 active site 1129794003793 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 1129794003794 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1129794003795 Mg++ binding site [ion binding]; other site 1129794003796 putative catalytic motif [active] 1129794003797 substrate binding site [chemical binding]; other site 1129794003798 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1129794003799 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1129794003800 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1129794003801 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1129794003802 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1129794003803 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1129794003804 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1129794003805 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1129794003806 active site 1129794003807 tetramer interface; other site 1129794003808 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1129794003809 Helix-hairpin-helix motif; Region: HHH; pfam00633 1129794003810 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 1129794003811 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1129794003812 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1129794003813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1129794003814 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1129794003815 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1129794003816 SecY interacting protein Syd; Provisional; Region: PRK04968 1129794003817 Protein of unknown function (DUF3192); Region: DUF3192; pfam11399 1129794003818 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1129794003819 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 1129794003820 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1129794003821 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1129794003822 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1129794003823 probable active site [active] 1129794003824 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1129794003825 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1129794003826 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1129794003827 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1129794003828 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1129794003829 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1129794003830 Riboflavin kinase; Region: Flavokinase; smart00904 1129794003831 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1129794003832 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1129794003833 active site 1129794003834 HIGH motif; other site 1129794003835 nucleotide binding site [chemical binding]; other site 1129794003836 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1129794003837 active site 1129794003838 KMSKS motif; other site 1129794003839 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1129794003840 tRNA binding surface [nucleotide binding]; other site 1129794003841 anticodon binding site; other site 1129794003842 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1129794003843 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1129794003844 lipoprotein signal peptidase; Provisional; Region: PRK14787 1129794003845 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794003846 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1129794003847 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1129794003848 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1129794003849 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794003850 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1129794003851 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794003852 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1129794003853 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1129794003854 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1129794003855 hypothetical protein; Provisional; Region: PRK10557 1129794003856 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1129794003857 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1129794003858 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1129794003859 PilX N-terminal; Region: PilX_N; pfam14341 1129794003860 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1129794003861 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1129794003862 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1129794003863 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1129794003864 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1129794003865 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1129794003866 active site 1129794003867 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794003868 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794003869 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1129794003870 endonuclease III; Provisional; Region: PRK10702 1129794003871 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1129794003872 minor groove reading motif; other site 1129794003873 helix-hairpin-helix signature motif; other site 1129794003874 substrate binding pocket [chemical binding]; other site 1129794003875 active site 1129794003876 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1129794003877 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1129794003878 electron transport complex protein RnfG; Validated; Region: PRK01908 1129794003879 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1129794003880 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1129794003881 SLBB domain; Region: SLBB; pfam10531 1129794003882 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1129794003883 electron transport complex protein RnfB; Provisional; Region: PRK05113 1129794003884 Putative Fe-S cluster; Region: FeS; pfam04060 1129794003885 4Fe-4S binding domain; Region: Fer4; pfam00037 1129794003886 electron transport complex protein RsxA; Provisional; Region: PRK05151 1129794003887 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149 1129794003888 putative efflux protein, MATE family; Region: matE; TIGR00797 1129794003889 excinuclease ABC subunit B; Provisional; Region: PRK05298 1129794003890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794003891 ATP binding site [chemical binding]; other site 1129794003892 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794003893 nucleotide binding region [chemical binding]; other site 1129794003894 ATP-binding site [chemical binding]; other site 1129794003895 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1129794003896 UvrB/uvrC motif; Region: UVR; pfam02151 1129794003897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794003898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794003899 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794003900 dimerization interface [polypeptide binding]; other site 1129794003901 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1129794003902 Ligand Binding Site [chemical binding]; other site 1129794003903 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1129794003904 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1129794003905 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794003906 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1129794003907 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1129794003908 active site 1129794003909 dimer interface [polypeptide binding]; other site 1129794003910 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1129794003911 Ligand Binding Site [chemical binding]; other site 1129794003912 Molecular Tunnel; other site 1129794003913 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1129794003914 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1129794003915 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1129794003916 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 1129794003917 PA/protease or protease-like domain interface [polypeptide binding]; other site 1129794003918 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 1129794003919 Peptidase family M28; Region: Peptidase_M28; pfam04389 1129794003920 metal binding site [ion binding]; metal-binding site 1129794003921 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 1129794003922 Chitin synthase; Region: Chitin_synth_2; pfam03142 1129794003923 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1129794003924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794003925 Walker A/P-loop; other site 1129794003926 ATP binding site [chemical binding]; other site 1129794003927 Q-loop/lid; other site 1129794003928 ABC transporter signature motif; other site 1129794003929 Walker B; other site 1129794003930 D-loop; other site 1129794003931 H-loop/switch region; other site 1129794003932 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1129794003933 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1129794003934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794003935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794003936 metal binding site [ion binding]; metal-binding site 1129794003937 active site 1129794003938 I-site; other site 1129794003939 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1129794003940 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1129794003941 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1129794003942 TrkA-N domain; Region: TrkA_N; pfam02254 1129794003943 TrkA-C domain; Region: TrkA_C; pfam02080 1129794003944 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1129794003945 carboxyltransferase (CT) interaction site; other site 1129794003946 biotinylation site [posttranslational modification]; other site 1129794003947 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1129794003948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1129794003949 oxyanion hole (OAH) forming residues; other site 1129794003950 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1129794003951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1129794003952 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1129794003953 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1129794003954 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1129794003955 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1129794003956 active site 1129794003957 catalytic tetrad [active] 1129794003958 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1129794003959 Predicted membrane protein [Function unknown]; Region: COG2855 1129794003960 TrkA-N domain; Region: TrkA_N; pfam02254 1129794003961 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1129794003962 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1129794003963 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794003964 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794003965 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794003966 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1129794003967 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1129794003968 DctM-like transporters; Region: DctM; pfam06808 1129794003969 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1129794003970 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1129794003971 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1129794003972 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1129794003973 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1129794003974 active site 1129794003975 catalytic site [active] 1129794003976 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1129794003977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794003978 DNA-binding site [nucleotide binding]; DNA binding site 1129794003979 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1129794003980 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1129794003981 Sulfatase; Region: Sulfatase; pfam00884 1129794003982 Surface antigen; Region: Bac_surface_Ag; pfam01103 1129794003983 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1129794003984 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1129794003985 BON domain; Region: BON; pfam04972 1129794003986 Helix-turn-helix domain; Region: HTH_38; pfam13936 1129794003987 DNA-binding interface [nucleotide binding]; DNA binding site 1129794003988 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1129794003989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1129794003990 catalytic core [active] 1129794003991 PAS domain S-box; Region: sensory_box; TIGR00229 1129794003992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794003993 putative active site [active] 1129794003994 heme pocket [chemical binding]; other site 1129794003995 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794003996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794003997 metal binding site [ion binding]; metal-binding site 1129794003998 active site 1129794003999 I-site; other site 1129794004000 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794004001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1129794004002 Integrase core domain; Region: rve; pfam00665 1129794004003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794004004 putative substrate translocation pore; other site 1129794004005 Nitrate and nitrite sensing; Region: NIT; pfam08376 1129794004006 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1129794004007 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794004008 dimer interface [polypeptide binding]; other site 1129794004009 putative CheW interface [polypeptide binding]; other site 1129794004010 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1129794004011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794004012 NAD(P) binding site [chemical binding]; other site 1129794004013 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 1129794004014 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1129794004015 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1129794004016 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 1129794004017 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1129794004018 disulfide bond formation protein B; Provisional; Region: PRK01749 1129794004019 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1129794004020 fatty acid metabolism regulator; Provisional; Region: PRK04984 1129794004021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794004022 DNA-binding site [nucleotide binding]; DNA binding site 1129794004023 FadR C-terminal domain; Region: FadR_C; pfam07840 1129794004024 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1129794004025 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 1129794004026 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1129794004027 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1129794004028 YceI-like domain; Region: YceI; pfam04264 1129794004029 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1129794004030 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 1129794004031 Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206 1129794004032 active site 1129794004033 nucleophile elbow; other site 1129794004034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1129794004035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1129794004036 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 1129794004037 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1129794004038 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1129794004039 P-loop; other site 1129794004040 Magnesium ion binding site [ion binding]; other site 1129794004041 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1129794004042 Magnesium ion binding site [ion binding]; other site 1129794004043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794004044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794004045 Bacterial transcriptional repressor; Region: TetR; pfam13972 1129794004046 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1129794004047 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1129794004048 choline dehydrogenase; Validated; Region: PRK02106 1129794004049 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1129794004050 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1129794004051 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1129794004052 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1129794004053 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1129794004054 active site 1129794004055 catalytic site [active] 1129794004056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1129794004057 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1129794004058 dimer interface [polypeptide binding]; other site 1129794004059 active site 1129794004060 metal binding site [ion binding]; metal-binding site 1129794004061 glutathione binding site [chemical binding]; other site 1129794004062 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1129794004063 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1129794004064 Type II transport protein GspH; Region: GspH; pfam12019 1129794004065 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1129794004066 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1129794004067 homodimer interface [polypeptide binding]; other site 1129794004068 NAD binding pocket [chemical binding]; other site 1129794004069 ATP binding pocket [chemical binding]; other site 1129794004070 Mg binding site [ion binding]; other site 1129794004071 active-site loop [active] 1129794004072 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1129794004073 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1129794004074 hypothetical protein; Provisional; Region: PRK05409 1129794004075 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 1129794004076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1129794004077 active site 1129794004078 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 1129794004079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794004080 Walker A motif; other site 1129794004081 ATP binding site [chemical binding]; other site 1129794004082 Walker B motif; other site 1129794004083 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1129794004084 arginine finger; other site 1129794004085 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1129794004086 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1129794004087 hypothetical protein; Validated; Region: PRK00153 1129794004088 recombination protein RecR; Reviewed; Region: recR; PRK00076 1129794004089 RecR protein; Region: RecR; pfam02132 1129794004090 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1129794004091 putative active site [active] 1129794004092 putative metal-binding site [ion binding]; other site 1129794004093 tetramer interface [polypeptide binding]; other site 1129794004094 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794004095 I-site; other site 1129794004096 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794004097 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794004098 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794004099 metal binding site [ion binding]; metal-binding site 1129794004100 active site 1129794004101 I-site; other site 1129794004102 heat shock protein 90; Provisional; Region: PRK05218 1129794004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794004104 ATP binding site [chemical binding]; other site 1129794004105 Mg2+ binding site [ion binding]; other site 1129794004106 G-X-G motif; other site 1129794004107 adenylate kinase; Reviewed; Region: adk; PRK00279 1129794004108 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1129794004109 AMP-binding site [chemical binding]; other site 1129794004110 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1129794004111 MAPEG family; Region: MAPEG; cl09190 1129794004112 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1129794004113 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1129794004114 putative dimer interface [polypeptide binding]; other site 1129794004115 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1129794004116 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1129794004117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794004118 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1129794004119 Walker A motif; other site 1129794004120 ATP binding site [chemical binding]; other site 1129794004121 Walker B motif; other site 1129794004122 arginine finger; other site 1129794004123 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1129794004124 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794004125 N-terminal plug; other site 1129794004126 ligand-binding site [chemical binding]; other site 1129794004127 Peptidase family M1; Region: Peptidase_M1; pfam01433 1129794004128 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1129794004129 Zn binding site [ion binding]; other site 1129794004130 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1129794004131 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1129794004132 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1129794004133 dimer interface [polypeptide binding]; other site 1129794004134 acyl-activating enzyme (AAE) consensus motif; other site 1129794004135 putative active site [active] 1129794004136 AMP binding site [chemical binding]; other site 1129794004137 putative CoA binding site [chemical binding]; other site 1129794004138 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1129794004139 classical (c) SDRs; Region: SDR_c; cd05233 1129794004140 NAD(P) binding site [chemical binding]; other site 1129794004141 active site 1129794004142 haloalkane dehalogenase; Provisional; Region: PRK00870 1129794004143 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1129794004144 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794004145 substrate binding site [chemical binding]; other site 1129794004146 oxyanion hole (OAH) forming residues; other site 1129794004147 trimer interface [polypeptide binding]; other site 1129794004148 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1129794004149 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1129794004150 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1129794004151 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1129794004152 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1129794004153 dimer interface [polypeptide binding]; other site 1129794004154 active site 1129794004155 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1129794004156 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1129794004157 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794004158 active site 1129794004159 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1129794004160 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794004161 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794004162 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794004163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794004164 active site 1129794004165 phosphorylation site [posttranslational modification] 1129794004166 intermolecular recognition site; other site 1129794004167 dimerization interface [polypeptide binding]; other site 1129794004168 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794004169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794004170 metal binding site [ion binding]; metal-binding site 1129794004171 active site 1129794004172 I-site; other site 1129794004173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794004174 putative active site [active] 1129794004175 heme pocket [chemical binding]; other site 1129794004176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794004177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794004178 dimer interface [polypeptide binding]; other site 1129794004179 phosphorylation site [posttranslational modification] 1129794004180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794004181 ATP binding site [chemical binding]; other site 1129794004182 Mg2+ binding site [ion binding]; other site 1129794004183 G-X-G motif; other site 1129794004184 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794004185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794004186 active site 1129794004187 phosphorylation site [posttranslational modification] 1129794004188 intermolecular recognition site; other site 1129794004189 dimerization interface [polypeptide binding]; other site 1129794004190 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1129794004191 putative binding surface; other site 1129794004192 active site 1129794004193 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794004194 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794004195 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794004196 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1129794004197 cyclase homology domain; Region: CHD; cd07302 1129794004198 nucleotidyl binding site; other site 1129794004199 metal binding site [ion binding]; metal-binding site 1129794004200 dimer interface [polypeptide binding]; other site 1129794004201 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1129794004202 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1129794004203 RNase E interface [polypeptide binding]; other site 1129794004204 trimer interface [polypeptide binding]; other site 1129794004205 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1129794004206 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1129794004207 RNase E interface [polypeptide binding]; other site 1129794004208 trimer interface [polypeptide binding]; other site 1129794004209 active site 1129794004210 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1129794004211 putative nucleic acid binding region [nucleotide binding]; other site 1129794004212 G-X-X-G motif; other site 1129794004213 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1129794004214 RNA binding site [nucleotide binding]; other site 1129794004215 domain interface; other site 1129794004216 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 1129794004217 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1129794004218 active site 1129794004219 phosphate binding residues; other site 1129794004220 catalytic residues [active] 1129794004221 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1129794004222 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1129794004223 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1129794004224 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1129794004225 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1129794004226 glycogen branching enzyme; Provisional; Region: PRK05402 1129794004227 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1129794004228 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1129794004229 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1129794004230 active site 1129794004231 catalytic site [active] 1129794004232 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1129794004233 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1129794004234 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1129794004235 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1129794004236 active site 1129794004237 catalytic site [active] 1129794004238 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1129794004239 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1129794004240 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1129794004241 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1129794004242 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794004243 catalytic residues [active] 1129794004244 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1129794004245 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 1129794004246 putative active site [active] 1129794004247 Zn binding site [ion binding]; other site 1129794004248 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1129794004249 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1129794004250 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1129794004251 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1129794004252 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1129794004253 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 1129794004254 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1129794004255 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1129794004256 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1129794004257 RNA binding surface [nucleotide binding]; other site 1129794004258 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1129794004259 probable active site [active] 1129794004260 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1129794004261 active site 1129794004262 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1129794004263 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794004264 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794004265 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 1129794004266 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1129794004267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794004268 S-adenosylmethionine binding site [chemical binding]; other site 1129794004269 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1129794004270 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1129794004271 TrkA-C domain; Region: TrkA_C; pfam02080 1129794004272 TrkA-C domain; Region: TrkA_C; pfam02080 1129794004273 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1129794004274 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1129794004275 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1129794004276 CysD dimerization site [polypeptide binding]; other site 1129794004277 G1 box; other site 1129794004278 putative GEF interaction site [polypeptide binding]; other site 1129794004279 GTP/Mg2+ binding site [chemical binding]; other site 1129794004280 Switch I region; other site 1129794004281 G2 box; other site 1129794004282 G3 box; other site 1129794004283 Switch II region; other site 1129794004284 G4 box; other site 1129794004285 G5 box; other site 1129794004286 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1129794004287 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1129794004288 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1129794004289 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1129794004290 active site 1129794004291 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1129794004292 ligand-binding site [chemical binding]; other site 1129794004293 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1129794004294 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1129794004295 Active Sites [active] 1129794004296 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1129794004297 Na binding site [ion binding]; other site 1129794004298 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1129794004299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1129794004300 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 1129794004301 RNA polymerase sigma factor; Provisional; Region: PRK12517 1129794004302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794004303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794004304 DNA binding residues [nucleotide binding] 1129794004305 Oxygen tolerance; Region: BatD; pfam13584 1129794004306 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1129794004307 metal ion-dependent adhesion site (MIDAS); other site 1129794004308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794004309 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1129794004310 TPR motif; other site 1129794004311 binding surface 1129794004312 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1129794004313 metal ion-dependent adhesion site (MIDAS); other site 1129794004314 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1129794004315 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1129794004316 Protein of unknown function DUF58; Region: DUF58; pfam01882 1129794004317 MoxR-like ATPases [General function prediction only]; Region: COG0714 1129794004318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794004319 Walker A motif; other site 1129794004320 ATP binding site [chemical binding]; other site 1129794004321 Walker B motif; other site 1129794004322 arginine finger; other site 1129794004323 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1129794004324 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1129794004325 dimer interface [polypeptide binding]; other site 1129794004326 active site 1129794004327 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1129794004328 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794004329 substrate binding site [chemical binding]; other site 1129794004330 oxyanion hole (OAH) forming residues; other site 1129794004331 trimer interface [polypeptide binding]; other site 1129794004332 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1129794004333 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1129794004334 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1129794004335 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1129794004336 PAS fold; Region: PAS_3; pfam08447 1129794004337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794004338 PAS domain; Region: PAS_9; pfam13426 1129794004339 putative active site [active] 1129794004340 heme pocket [chemical binding]; other site 1129794004341 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794004342 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794004343 metal binding site [ion binding]; metal-binding site 1129794004344 active site 1129794004345 I-site; other site 1129794004346 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794004347 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 1129794004348 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1129794004349 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794004350 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794004351 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1129794004352 catalytic core [active] 1129794004353 Domain of unknown function DUF21; Region: DUF21; pfam01595 1129794004354 hypothetical protein; Provisional; Region: PRK11573 1129794004355 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1129794004356 Transporter associated domain; Region: CorC_HlyC; smart01091 1129794004357 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1129794004358 signal recognition particle protein; Provisional; Region: PRK10867 1129794004359 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1129794004360 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1129794004361 P loop; other site 1129794004362 GTP binding site [chemical binding]; other site 1129794004363 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1129794004364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794004365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794004366 metal binding site [ion binding]; metal-binding site 1129794004367 active site 1129794004368 I-site; other site 1129794004369 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794004370 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1129794004371 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1129794004372 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1129794004373 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1129794004374 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1129794004375 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1129794004376 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 1129794004377 Na binding site [ion binding]; other site 1129794004378 substrate binding site [chemical binding]; other site 1129794004379 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1129794004380 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1129794004381 active site 1129794004382 NAD binding site [chemical binding]; other site 1129794004383 metal binding site [ion binding]; metal-binding site 1129794004384 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1129794004385 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1129794004386 heme-binding residues [chemical binding]; other site 1129794004387 HEAT repeats; Region: HEAT_2; pfam13646 1129794004388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794004389 TPR motif; other site 1129794004390 binding surface 1129794004391 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1129794004392 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1129794004393 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1129794004394 Walker A/P-loop; other site 1129794004395 ATP binding site [chemical binding]; other site 1129794004396 Q-loop/lid; other site 1129794004397 ABC transporter signature motif; other site 1129794004398 Walker B; other site 1129794004399 D-loop; other site 1129794004400 H-loop/switch region; other site 1129794004401 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1129794004402 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1129794004403 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1129794004404 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1129794004405 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1129794004406 nudix motif; other site 1129794004407 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 1129794004408 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 1129794004409 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1129794004410 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1129794004411 active site lid residues [active] 1129794004412 substrate binding pocket [chemical binding]; other site 1129794004413 catalytic residues [active] 1129794004414 substrate-Mg2+ binding site; other site 1129794004415 aspartate-rich region 1; other site 1129794004416 aspartate-rich region 2; other site 1129794004417 phytoene desaturase; Region: crtI_fam; TIGR02734 1129794004418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1129794004419 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1129794004420 substrate binding pocket [chemical binding]; other site 1129794004421 aspartate-rich region 1; other site 1129794004422 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 1129794004423 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1129794004424 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1129794004425 putative active site [active] 1129794004426 putative catalytic site [active] 1129794004427 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1129794004428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794004429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794004430 phosphorylation site [posttranslational modification] 1129794004431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794004432 ATP binding site [chemical binding]; other site 1129794004433 Mg2+ binding site [ion binding]; other site 1129794004434 G-X-G motif; other site 1129794004435 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794004436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794004437 active site 1129794004438 phosphorylation site [posttranslational modification] 1129794004439 intermolecular recognition site; other site 1129794004440 dimerization interface [polypeptide binding]; other site 1129794004441 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1129794004442 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1129794004443 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1129794004444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794004445 Walker A/P-loop; other site 1129794004446 ATP binding site [chemical binding]; other site 1129794004447 Q-loop/lid; other site 1129794004448 ABC transporter signature motif; other site 1129794004449 Walker B; other site 1129794004450 D-loop; other site 1129794004451 H-loop/switch region; other site 1129794004452 S-formylglutathione hydrolase; Region: PLN02442 1129794004453 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1129794004454 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1129794004455 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1129794004456 substrate binding site [chemical binding]; other site 1129794004457 catalytic Zn binding site [ion binding]; other site 1129794004458 NAD binding site [chemical binding]; other site 1129794004459 structural Zn binding site [ion binding]; other site 1129794004460 dimer interface [polypeptide binding]; other site 1129794004461 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1129794004462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794004463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794004464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794004465 dimerization interface [polypeptide binding]; other site 1129794004466 phosphoethanolamine N-methyltransferase; Provisional; Region: PTZ00098 1129794004467 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1129794004468 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794004469 Haem-binding domain; Region: Haem_bd; pfam14376 1129794004470 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 1129794004471 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1129794004472 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1129794004473 putative active site [active] 1129794004474 metal binding site [ion binding]; metal-binding site 1129794004475 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1129794004476 active site 1129794004477 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794004478 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1129794004479 TAP-like protein; Region: Abhydrolase_4; pfam08386 1129794004480 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1129794004481 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1129794004482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794004483 active site 1129794004484 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1129794004485 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1129794004486 Conserved TM helix; Region: TM_helix; pfam05552 1129794004487 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794004488 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1129794004489 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1129794004490 metal-binding site [ion binding] 1129794004491 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1129794004492 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1129794004493 metal-binding site [ion binding] 1129794004494 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1129794004495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794004496 motif II; other site 1129794004497 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1129794004498 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1129794004499 DNA binding residues [nucleotide binding] 1129794004500 dimer interface [polypeptide binding]; other site 1129794004501 copper binding site [ion binding]; other site 1129794004502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794004503 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1129794004504 Walker A/P-loop; other site 1129794004505 ATP binding site [chemical binding]; other site 1129794004506 Q-loop/lid; other site 1129794004507 ABC transporter signature motif; other site 1129794004508 Walker B; other site 1129794004509 D-loop; other site 1129794004510 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1129794004511 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794004512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794004513 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794004514 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1129794004515 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1129794004516 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1129794004517 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1129794004518 FAD binding pocket [chemical binding]; other site 1129794004519 FAD binding motif [chemical binding]; other site 1129794004520 phosphate binding motif [ion binding]; other site 1129794004521 beta-alpha-beta structure motif; other site 1129794004522 NAD binding pocket [chemical binding]; other site 1129794004523 lipoyl synthase; Provisional; Region: PRK05481 1129794004524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794004525 FeS/SAM binding site; other site 1129794004526 BolA-like protein; Region: BolA; pfam01722 1129794004527 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1129794004528 Domain of unknown function DUF59; Region: DUF59; cl00941 1129794004529 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1129794004530 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1129794004531 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1129794004532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794004533 catalytic residue [active] 1129794004534 FeS assembly protein SufD; Region: sufD; TIGR01981 1129794004535 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1129794004536 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1129794004537 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1129794004538 Walker A/P-loop; other site 1129794004539 ATP binding site [chemical binding]; other site 1129794004540 Q-loop/lid; other site 1129794004541 ABC transporter signature motif; other site 1129794004542 Walker B; other site 1129794004543 D-loop; other site 1129794004544 H-loop/switch region; other site 1129794004545 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1129794004546 putative ABC transporter; Region: ycf24; CHL00085 1129794004547 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1129794004548 Transcriptional regulator; Region: Rrf2; pfam02082 1129794004549 transcriptional regulator BetI; Validated; Region: PRK00767 1129794004550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794004551 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1129794004552 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794004553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794004554 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1129794004555 Ligand binding site; other site 1129794004556 Putative Catalytic site; other site 1129794004557 DXD motif; other site 1129794004558 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1129794004559 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1129794004560 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1129794004561 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1129794004562 Sulfatase; Region: Sulfatase; pfam00884 1129794004563 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1129794004564 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1129794004565 putative active site [active] 1129794004566 putative FMN binding site [chemical binding]; other site 1129794004567 putative substrate binding site [chemical binding]; other site 1129794004568 putative catalytic residue [active] 1129794004569 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1129794004570 Amidinotransferase; Region: Amidinotransf; cl12043 1129794004571 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1129794004572 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1129794004573 SmpB-tmRNA interface; other site 1129794004574 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1129794004575 putative coenzyme Q binding site [chemical binding]; other site 1129794004576 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 1129794004577 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1129794004578 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1129794004579 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1129794004580 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1129794004581 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1129794004582 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1129794004583 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1129794004584 FAD binding domain; Region: FAD_binding_4; pfam01565 1129794004585 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1129794004586 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1129794004587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1129794004588 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1129794004589 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794004590 Heme NO binding associated; Region: HNOBA; pfam07701 1129794004591 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1129794004592 cyclase homology domain; Region: CHD; cd07302 1129794004593 nucleotidyl binding site; other site 1129794004594 metal binding site [ion binding]; metal-binding site 1129794004595 dimer interface [polypeptide binding]; other site 1129794004596 adenylosuccinate lyase; Provisional; Region: PRK09285 1129794004597 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1129794004598 tetramer interface [polypeptide binding]; other site 1129794004599 active site 1129794004600 putative lysogenization regulator; Reviewed; Region: PRK00218 1129794004601 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1129794004602 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1129794004603 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 1129794004604 nudix motif; other site 1129794004605 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1129794004606 Putative addiction module component; Region: Unstab_antitox; pfam09720 1129794004607 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1129794004608 pseudouridine synthase; Region: TIGR00093 1129794004609 active site 1129794004610 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1129794004611 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1129794004612 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1129794004613 DNA-binding site [nucleotide binding]; DNA binding site 1129794004614 RNA-binding motif; other site 1129794004615 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1129794004616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794004617 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1129794004618 Walker A motif; other site 1129794004619 ATP binding site [chemical binding]; other site 1129794004620 Walker B motif; other site 1129794004621 arginine finger; other site 1129794004622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794004623 Walker A motif; other site 1129794004624 ATP binding site [chemical binding]; other site 1129794004625 Walker B motif; other site 1129794004626 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1129794004627 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1129794004628 rRNA binding site [nucleotide binding]; other site 1129794004629 predicted 30S ribosome binding site; other site 1129794004630 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1129794004631 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1129794004632 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1129794004633 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317 1129794004634 thioredoxin reductase; Provisional; Region: PRK10262 1129794004635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794004636 phosphate acetyltransferase; Reviewed; Region: PRK05632 1129794004637 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1129794004638 DRTGG domain; Region: DRTGG; pfam07085 1129794004639 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1129794004640 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1129794004641 propionate/acetate kinase; Provisional; Region: PRK12379 1129794004642 Protein of unknown function, DUF412; Region: DUF412; pfam04217 1129794004643 hypothetical protein; Provisional; Region: PRK04860 1129794004644 SprT homologues; Region: SprT; cl01182 1129794004645 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1129794004646 protease 4; Provisional; Region: PRK10949 1129794004647 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1129794004648 tandem repeat interface [polypeptide binding]; other site 1129794004649 oligomer interface [polypeptide binding]; other site 1129794004650 active site residues [active] 1129794004651 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1129794004652 tandem repeat interface [polypeptide binding]; other site 1129794004653 oligomer interface [polypeptide binding]; other site 1129794004654 active site residues [active] 1129794004655 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1129794004656 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1129794004657 active site 1129794004658 FMN binding site [chemical binding]; other site 1129794004659 2,4-decadienoyl-CoA binding site; other site 1129794004660 catalytic residue [active] 1129794004661 4Fe-4S cluster binding site [ion binding]; other site 1129794004662 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1129794004663 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794004664 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794004665 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794004666 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1129794004667 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1129794004668 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1129794004669 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1129794004670 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1129794004671 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1129794004672 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1129794004673 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1129794004674 DNA-binding site [nucleotide binding]; DNA binding site 1129794004675 RNA-binding motif; other site 1129794004676 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1129794004677 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1129794004678 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1129794004679 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1129794004680 putative active site [active] 1129794004681 putative metal binding site [ion binding]; other site 1129794004682 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1129794004683 substrate binding site [chemical binding]; other site 1129794004684 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1129794004685 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1129794004686 active site 1129794004687 HIGH motif; other site 1129794004688 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1129794004689 KMSKS motif; other site 1129794004690 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1129794004691 tRNA binding surface [nucleotide binding]; other site 1129794004692 anticodon binding site; other site 1129794004693 Phospholipid methyltransferase; Region: PEMT; cl17370 1129794004694 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794004695 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1129794004696 catalytic residue [active] 1129794004697 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1129794004698 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1129794004699 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1129794004700 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1129794004701 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1129794004702 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1129794004703 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794004704 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1129794004705 FtsX-like permease family; Region: FtsX; pfam02687 1129794004706 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1129794004707 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1129794004708 Walker A/P-loop; other site 1129794004709 ATP binding site [chemical binding]; other site 1129794004710 Q-loop/lid; other site 1129794004711 ABC transporter signature motif; other site 1129794004712 Walker B; other site 1129794004713 D-loop; other site 1129794004714 H-loop/switch region; other site 1129794004715 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 1129794004716 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1129794004717 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1129794004718 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1129794004719 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1129794004720 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1129794004721 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1129794004722 putative catalytic site [active] 1129794004723 putative metal binding site [ion binding]; other site 1129794004724 putative phosphate binding site [ion binding]; other site 1129794004725 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1129794004726 MerC mercury resistance protein; Region: MerC; pfam03203 1129794004727 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1129794004728 metal binding site 2 [ion binding]; metal-binding site 1129794004729 putative DNA binding helix; other site 1129794004730 metal binding site 1 [ion binding]; metal-binding site 1129794004731 dimer interface [polypeptide binding]; other site 1129794004732 structural Zn2+ binding site [ion binding]; other site 1129794004733 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1129794004734 MerC mercury resistance protein; Region: MerC; pfam03203 1129794004735 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1129794004736 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794004737 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794004738 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1129794004739 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1129794004740 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1129794004741 active site 1129794004742 HIGH motif; other site 1129794004743 KMSKS motif; other site 1129794004744 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1129794004745 tRNA binding surface [nucleotide binding]; other site 1129794004746 anticodon binding site; other site 1129794004747 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1129794004748 dimer interface [polypeptide binding]; other site 1129794004749 putative tRNA-binding site [nucleotide binding]; other site 1129794004750 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1129794004751 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1129794004752 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1129794004753 trimer interface [polypeptide binding]; other site 1129794004754 active site 1129794004755 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1129794004756 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1129794004757 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1129794004758 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1129794004759 [2Fe-2S] cluster binding site [ion binding]; other site 1129794004760 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 1129794004761 putative alpha subunit interface [polypeptide binding]; other site 1129794004762 putative active site [active] 1129794004763 putative substrate binding site [chemical binding]; other site 1129794004764 Fe binding site [ion binding]; other site 1129794004765 Phospholipid methyltransferase; Region: PEMT; cl17370 1129794004766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794004767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794004768 putative substrate translocation pore; other site 1129794004769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794004770 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794004771 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794004772 metal binding site [ion binding]; metal-binding site 1129794004773 active site 1129794004774 I-site; other site 1129794004775 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1129794004776 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1129794004777 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1129794004778 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1129794004779 Putative phosphatase (DUF442); Region: DUF442; cl17385 1129794004780 PGAP1-like protein; Region: PGAP1; pfam07819 1129794004781 Predicted membrane protein [Function unknown]; Region: COG1971 1129794004782 Domain of unknown function DUF; Region: DUF204; pfam02659 1129794004783 Domain of unknown function DUF; Region: DUF204; pfam02659 1129794004784 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794004785 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794004786 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794004787 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1129794004788 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1129794004789 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1129794004790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794004791 Coenzyme A binding pocket [chemical binding]; other site 1129794004792 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1129794004793 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1129794004794 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1129794004795 putative hydrophobic ligand binding site [chemical binding]; other site 1129794004796 protein interface [polypeptide binding]; other site 1129794004797 gate; other site 1129794004798 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794004799 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794004800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794004801 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1129794004802 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1129794004803 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1129794004804 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1129794004805 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1129794004806 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794004807 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794004808 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1129794004809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794004810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1129794004811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794004812 dimer interface [polypeptide binding]; other site 1129794004813 phosphorylation site [posttranslational modification] 1129794004814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794004815 ATP binding site [chemical binding]; other site 1129794004816 Mg2+ binding site [ion binding]; other site 1129794004817 G-X-G motif; other site 1129794004818 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794004819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794004820 active site 1129794004821 phosphorylation site [posttranslational modification] 1129794004822 intermolecular recognition site; other site 1129794004823 dimerization interface [polypeptide binding]; other site 1129794004824 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794004825 DNA binding site [nucleotide binding] 1129794004826 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794004827 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794004828 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 1129794004829 MltA-interacting protein MipA; Region: MipA; cl01504 1129794004830 Predicted membrane protein [Function unknown]; Region: COG2311 1129794004831 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1129794004832 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1129794004833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794004834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1129794004835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794004836 dimer interface [polypeptide binding]; other site 1129794004837 phosphorylation site [posttranslational modification] 1129794004838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1129794004839 ATP binding site [chemical binding]; other site 1129794004840 Mg2+ binding site [ion binding]; other site 1129794004841 G-X-G motif; other site 1129794004842 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794004843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794004844 active site 1129794004845 phosphorylation site [posttranslational modification] 1129794004846 intermolecular recognition site; other site 1129794004847 dimerization interface [polypeptide binding]; other site 1129794004848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794004849 DNA binding site [nucleotide binding] 1129794004850 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1129794004851 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 1129794004852 dimer interface [polypeptide binding]; other site 1129794004853 active site 1129794004854 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1129794004855 catalytic residues [active] 1129794004856 substrate binding site [chemical binding]; other site 1129794004857 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 1129794004858 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794004859 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794004860 acyl-activating enzyme (AAE) consensus motif; other site 1129794004861 acyl-activating enzyme (AAE) consensus motif; other site 1129794004862 AMP binding site [chemical binding]; other site 1129794004863 active site 1129794004864 CoA binding site [chemical binding]; other site 1129794004865 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1129794004866 putative acyl-acceptor binding pocket; other site 1129794004867 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1129794004868 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1129794004869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794004870 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1129794004871 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1129794004872 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1129794004873 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1129794004874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794004875 Walker A/P-loop; other site 1129794004876 ATP binding site [chemical binding]; other site 1129794004877 Q-loop/lid; other site 1129794004878 ABC transporter signature motif; other site 1129794004879 Walker B; other site 1129794004880 D-loop; other site 1129794004881 H-loop/switch region; other site 1129794004882 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1129794004883 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1129794004884 ATP binding site [chemical binding]; other site 1129794004885 substrate interface [chemical binding]; other site 1129794004886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1129794004887 active site 1129794004888 dimerization interface [polypeptide binding]; other site 1129794004889 MoeZ/MoeB domain; Region: MoeZ_MoeB; pfam05237 1129794004890 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794004891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1129794004892 substrate binding pocket [chemical binding]; other site 1129794004893 membrane-bound complex binding site; other site 1129794004894 hinge residues; other site 1129794004895 PhoD-like phosphatase; Region: PhoD; pfam09423 1129794004896 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1129794004897 putative active site [active] 1129794004898 putative metal binding site [ion binding]; other site 1129794004899 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1129794004900 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1129794004901 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1129794004902 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1129794004903 putative di-iron ligands [ion binding]; other site 1129794004904 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1129794004905 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1129794004906 FAD binding pocket [chemical binding]; other site 1129794004907 FAD binding motif [chemical binding]; other site 1129794004908 phosphate binding motif [ion binding]; other site 1129794004909 beta-alpha-beta structure motif; other site 1129794004910 NAD binding pocket [chemical binding]; other site 1129794004911 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794004912 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1129794004913 catalytic loop [active] 1129794004914 iron binding site [ion binding]; other site 1129794004915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794004916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794004917 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1129794004918 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1129794004919 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794004920 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1129794004921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794004922 DNA-binding site [nucleotide binding]; DNA binding site 1129794004923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1129794004924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794004925 homodimer interface [polypeptide binding]; other site 1129794004926 catalytic residue [active] 1129794004927 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1129794004928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794004929 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1129794004930 metal binding site 2 [ion binding]; metal-binding site 1129794004931 metal binding site 1 [ion binding]; metal-binding site 1129794004932 dimer interface [polypeptide binding]; other site 1129794004933 structural Zn2+ binding site [ion binding]; other site 1129794004934 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1129794004935 putative DNA binding helix; other site 1129794004936 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1129794004937 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1129794004938 FAD binding pocket [chemical binding]; other site 1129794004939 FAD binding motif [chemical binding]; other site 1129794004940 phosphate binding motif [ion binding]; other site 1129794004941 beta-alpha-beta structure motif; other site 1129794004942 NAD binding pocket [chemical binding]; other site 1129794004943 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1129794004944 ApbE family; Region: ApbE; pfam02424 1129794004945 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 1129794004946 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794004947 N-terminal plug; other site 1129794004948 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1129794004949 ligand-binding site [chemical binding]; other site 1129794004950 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1129794004951 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1129794004952 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1129794004953 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1129794004954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794004955 TPR motif; other site 1129794004956 binding surface 1129794004957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794004958 binding surface 1129794004959 TPR motif; other site 1129794004960 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1129794004961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 1129794004962 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794004963 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794004964 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794004965 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794004966 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1129794004967 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1129794004968 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1129794004969 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1129794004970 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1129794004971 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1129794004972 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794004973 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1129794004974 dimer interface [polypeptide binding]; other site 1129794004975 N-terminal domain interface [polypeptide binding]; other site 1129794004976 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1129794004977 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1129794004978 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1129794004979 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1129794004980 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1129794004981 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1129794004982 MarR family; Region: MarR_2; pfam12802 1129794004983 MarR family; Region: MarR_2; cl17246 1129794004984 TPR repeat; Region: TPR_11; pfam13414 1129794004985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794004986 TPR motif; other site 1129794004987 binding surface 1129794004988 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794004989 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794004990 Beta-lactamase; Region: Beta-lactamase; cl17358 1129794004991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794004992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794004993 putative substrate translocation pore; other site 1129794004994 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794004995 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794004996 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794004997 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1129794004998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1129794004999 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1129794005000 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1129794005001 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1129794005002 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 1129794005003 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1129794005004 methionine synthase; Provisional; Region: PRK01207 1129794005005 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1129794005006 substrate binding site [chemical binding]; other site 1129794005007 THF binding site; other site 1129794005008 zinc-binding site [ion binding]; other site 1129794005009 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1129794005010 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1129794005011 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1129794005012 RimM N-terminal domain; Region: RimM; pfam01782 1129794005013 PRC-barrel domain; Region: PRC; pfam05239 1129794005014 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1129794005015 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1129794005016 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1129794005017 active site 1129794005018 metal binding site [ion binding]; metal-binding site 1129794005019 Ferredoxin [Energy production and conversion]; Region: COG1146 1129794005020 4Fe-4S binding domain; Region: Fer4; pfam00037 1129794005021 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1129794005022 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1129794005023 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1129794005024 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1129794005025 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1129794005026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794005027 S-adenosylmethionine binding site [chemical binding]; other site 1129794005028 maltose O-acetyltransferase; Provisional; Region: PRK10092 1129794005029 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1129794005030 active site 1129794005031 substrate binding site [chemical binding]; other site 1129794005032 trimer interface [polypeptide binding]; other site 1129794005033 CoA binding site [chemical binding]; other site 1129794005034 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1129794005035 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1129794005036 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1129794005037 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1129794005038 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1129794005039 Chorismate mutase type II; Region: CM_2; cl00693 1129794005040 prephenate dehydrogenase; Validated; Region: PRK08507 1129794005041 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1129794005042 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1129794005043 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1129794005044 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1129794005045 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1129794005046 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794005047 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794005048 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1129794005049 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1129794005050 dimer interface [polypeptide binding]; other site 1129794005051 active site 1129794005052 citrylCoA binding site [chemical binding]; other site 1129794005053 NADH binding [chemical binding]; other site 1129794005054 cationic pore residues; other site 1129794005055 oxalacetate/citrate binding site [chemical binding]; other site 1129794005056 coenzyme A binding site [chemical binding]; other site 1129794005057 catalytic triad [active] 1129794005058 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1129794005059 Iron-sulfur protein interface; other site 1129794005060 proximal quinone binding site [chemical binding]; other site 1129794005061 SdhD (CybS) interface [polypeptide binding]; other site 1129794005062 proximal heme binding site [chemical binding]; other site 1129794005063 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1129794005064 SdhC subunit interface [polypeptide binding]; other site 1129794005065 proximal heme binding site [chemical binding]; other site 1129794005066 cardiolipin binding site; other site 1129794005067 Iron-sulfur protein interface; other site 1129794005068 proximal quinone binding site [chemical binding]; other site 1129794005069 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1129794005070 L-aspartate oxidase; Provisional; Region: PRK06175 1129794005071 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1129794005072 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1129794005073 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1129794005074 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1129794005075 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1129794005076 TPP-binding site [chemical binding]; other site 1129794005077 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1129794005078 PYR/PP interface [polypeptide binding]; other site 1129794005079 dimer interface [polypeptide binding]; other site 1129794005080 TPP binding site [chemical binding]; other site 1129794005081 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1129794005082 E3 interaction surface; other site 1129794005083 lipoyl attachment site [posttranslational modification]; other site 1129794005084 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1129794005085 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1129794005086 E3 interaction surface; other site 1129794005087 lipoyl attachment site [posttranslational modification]; other site 1129794005088 e3 binding domain; Region: E3_binding; pfam02817 1129794005089 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1129794005090 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1129794005091 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1129794005092 CoA-ligase; Region: Ligase_CoA; pfam00549 1129794005093 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1129794005094 CoA binding domain; Region: CoA_binding; smart00881 1129794005095 CoA-ligase; Region: Ligase_CoA; pfam00549 1129794005096 Cupin-like domain; Region: Cupin_8; pfam13621 1129794005097 Cupin-like domain; Region: Cupin_8; pfam13621 1129794005098 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1129794005099 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005100 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005101 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1129794005102 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1129794005103 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1129794005104 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005105 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005106 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1129794005107 carbohydrate binding site [chemical binding]; other site 1129794005108 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1129794005109 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1129794005110 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1129794005111 Ca binding site [ion binding]; other site 1129794005112 active site 1129794005113 catalytic site [active] 1129794005114 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1129794005115 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 1129794005116 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 1129794005117 Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861 1129794005118 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1129794005119 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1129794005120 active site 1129794005121 catalytic site [active] 1129794005122 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1129794005123 putative ligand binding site [chemical binding]; other site 1129794005124 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1129794005125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794005126 motif II; other site 1129794005127 hypothetical protein; Provisional; Region: PRK10621 1129794005128 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1129794005129 CHASE domain; Region: CHASE; cl01369 1129794005130 PAS domain; Region: PAS_9; pfam13426 1129794005131 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794005132 putative active site [active] 1129794005133 heme pocket [chemical binding]; other site 1129794005134 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1129794005135 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794005136 putative active site [active] 1129794005137 heme pocket [chemical binding]; other site 1129794005138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794005139 dimer interface [polypeptide binding]; other site 1129794005140 phosphorylation site [posttranslational modification] 1129794005141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794005142 ATP binding site [chemical binding]; other site 1129794005143 Mg2+ binding site [ion binding]; other site 1129794005144 G-X-G motif; other site 1129794005145 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1129794005146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794005147 active site 1129794005148 phosphorylation site [posttranslational modification] 1129794005149 intermolecular recognition site; other site 1129794005150 dimerization interface [polypeptide binding]; other site 1129794005151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794005152 DNA binding residues [nucleotide binding] 1129794005153 dimerization interface [polypeptide binding]; other site 1129794005154 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1129794005155 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1129794005156 HflK protein; Region: hflK; TIGR01933 1129794005157 HflC protein; Region: hflC; TIGR01932 1129794005158 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1129794005159 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1129794005160 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1129794005161 catalytic triad [active] 1129794005162 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1129794005163 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1129794005164 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1129794005165 active site 1129794005166 nucleophile elbow; other site 1129794005167 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1129794005168 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1129794005169 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1129794005170 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1129794005171 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1129794005172 Amidohydrolase; Region: Amidohydro_4; pfam13147 1129794005173 active site 1129794005174 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1129794005175 dimer interface [polypeptide binding]; other site 1129794005176 [2Fe-2S] cluster binding site [ion binding]; other site 1129794005177 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 1129794005178 metal binding site 2 [ion binding]; metal-binding site 1129794005179 putative DNA binding helix; other site 1129794005180 metal binding site 1 [ion binding]; metal-binding site 1129794005181 dimer interface [polypeptide binding]; other site 1129794005182 structural Zn2+ binding site [ion binding]; other site 1129794005183 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1129794005184 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1129794005185 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1129794005186 ABC 3 transport family; Region: ABC-3; pfam00950 1129794005187 ABC-ATPase subunit interface; other site 1129794005188 dimer interface [polypeptide binding]; other site 1129794005189 putative PBP binding regions; other site 1129794005190 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1129794005191 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1129794005192 intersubunit interface [polypeptide binding]; other site 1129794005193 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1129794005194 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1129794005195 P-loop, Walker A motif; other site 1129794005196 Base recognition motif; other site 1129794005197 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1129794005198 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794005199 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794005200 N-terminal plug; other site 1129794005201 ligand-binding site [chemical binding]; other site 1129794005202 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1129794005203 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1129794005204 Conserved TM helix; Region: TM_helix; pfam05552 1129794005205 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794005206 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1129794005207 Proline dehydrogenase; Region: Pro_dh; pfam01619 1129794005208 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1129794005209 Glutamate binding site [chemical binding]; other site 1129794005210 NAD binding site [chemical binding]; other site 1129794005211 catalytic residues [active] 1129794005212 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1129794005213 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1129794005214 NAD(P) binding site [chemical binding]; other site 1129794005215 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1129794005216 Protein export membrane protein; Region: SecD_SecF; cl14618 1129794005217 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1129794005218 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794005219 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1129794005220 Ligand Binding Site [chemical binding]; other site 1129794005221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794005222 Coenzyme A binding pocket [chemical binding]; other site 1129794005223 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1129794005224 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1129794005225 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1129794005226 Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993 1129794005227 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 1129794005228 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1129794005229 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1129794005230 Fasciclin domain; Region: Fasciclin; cl02663 1129794005231 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1129794005232 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1129794005233 dimerization interface [polypeptide binding]; other site 1129794005234 DPS ferroxidase diiron center [ion binding]; other site 1129794005235 ion pore; other site 1129794005236 aconitate hydratase; Validated; Region: PRK09277 1129794005237 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1129794005238 substrate binding site [chemical binding]; other site 1129794005239 ligand binding site [chemical binding]; other site 1129794005240 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1129794005241 substrate binding site [chemical binding]; other site 1129794005242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1129794005243 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 1129794005244 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1129794005245 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1129794005246 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1129794005247 putative active site pocket [active] 1129794005248 metal binding site [ion binding]; metal-binding site 1129794005249 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005250 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005251 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005252 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1129794005253 Sulfatase; Region: Sulfatase; pfam00884 1129794005254 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1129794005255 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1129794005256 Bacterial transcriptional regulator; Region: IclR; pfam01614 1129794005257 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1129794005258 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1129794005259 Domain of unknown function (DUF718); Region: DUF718; cl01281 1129794005260 Transposase; Region: HTH_Tnp_1; pfam01527 1129794005261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794005262 putative transposase OrfB; Reviewed; Region: PHA02517 1129794005263 HTH-like domain; Region: HTH_21; pfam13276 1129794005264 Integrase core domain; Region: rve; pfam00665 1129794005265 Integrase core domain; Region: rve_2; pfam13333 1129794005266 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1129794005267 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1129794005268 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1129794005269 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1129794005270 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1129794005271 classical (c) SDRs; Region: SDR_c; cd05233 1129794005272 NAD(P) binding site [chemical binding]; other site 1129794005273 active site 1129794005274 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1129794005275 Amidohydrolase; Region: Amidohydro_2; pfam04909 1129794005276 active site 1129794005277 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1129794005278 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1129794005279 active site 1129794005280 catalytic tetrad [active] 1129794005281 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1129794005282 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1129794005283 phosphate binding site [ion binding]; other site 1129794005284 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1129794005285 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 1129794005286 putative active site pocket [active] 1129794005287 metal binding site [ion binding]; metal-binding site 1129794005288 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1129794005289 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1129794005290 Bacterial transcriptional regulator; Region: IclR; pfam01614 1129794005291 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005292 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005293 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1129794005294 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1129794005295 Domain of unknown function (DUF718); Region: DUF718; cl01281 1129794005296 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794005297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1129794005298 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1129794005299 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1129794005300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794005301 DNA-binding site [nucleotide binding]; DNA binding site 1129794005302 FCD domain; Region: FCD; pfam07729 1129794005303 MFS/sugar transport protein; Region: MFS_2; pfam13347 1129794005304 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1129794005305 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1129794005306 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1129794005307 metal binding site [ion binding]; metal-binding site 1129794005308 substrate binding pocket [chemical binding]; other site 1129794005309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794005310 DNA-binding site [nucleotide binding]; DNA binding site 1129794005311 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1129794005312 FCD domain; Region: FCD; pfam07729 1129794005313 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1129794005314 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1129794005315 Na binding site [ion binding]; other site 1129794005316 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1129794005317 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1129794005318 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1129794005319 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1129794005320 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005321 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005322 Domain of unknown function (DUF718); Region: DUF718; cl01281 1129794005323 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1129794005324 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1129794005325 Na binding site [ion binding]; other site 1129794005326 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1129794005327 putative ligand binding site [chemical binding]; other site 1129794005328 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1129794005329 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1129794005330 phosphate binding site [ion binding]; other site 1129794005331 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1129794005332 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1129794005333 active site 1129794005334 catalytic tetrad [active] 1129794005335 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1129794005336 Amidohydrolase; Region: Amidohydro_2; pfam04909 1129794005337 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1129794005338 classical (c) SDRs; Region: SDR_c; cd05233 1129794005339 NAD(P) binding site [chemical binding]; other site 1129794005340 active site 1129794005341 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1129794005342 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1129794005343 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794005344 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1129794005345 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1129794005346 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1129794005347 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1129794005348 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1129794005349 substrate binding site [chemical binding]; other site 1129794005350 ATP binding site [chemical binding]; other site 1129794005351 glucuronate isomerase; Reviewed; Region: PRK02925 1129794005352 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1129794005353 mannonate dehydratase; Provisional; Region: PRK03906 1129794005354 mannonate dehydratase; Region: uxuA; TIGR00695 1129794005355 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1129794005356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794005357 DNA-binding site [nucleotide binding]; DNA binding site 1129794005358 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1129794005359 xylose isomerase; Provisional; Region: PRK05474 1129794005360 xylose isomerase; Region: xylose_isom_A; TIGR02630 1129794005361 xylulokinase; Provisional; Region: PRK15027 1129794005362 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1129794005363 N- and C-terminal domain interface [polypeptide binding]; other site 1129794005364 active site 1129794005365 MgATP binding site [chemical binding]; other site 1129794005366 catalytic site [active] 1129794005367 metal binding site [ion binding]; metal-binding site 1129794005368 xylulose binding site [chemical binding]; other site 1129794005369 homodimer interface [polypeptide binding]; other site 1129794005370 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1129794005371 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1129794005372 putative dimerization interface [polypeptide binding]; other site 1129794005373 putative ligand binding site [chemical binding]; other site 1129794005374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794005375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794005376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1129794005377 Restriction endonuclease; Region: Mrr_cat; pfam04471 1129794005378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1129794005379 active site 1129794005380 DNA binding site [nucleotide binding] 1129794005381 Int/Topo IB signature motif; other site 1129794005382 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1129794005383 DNA binding residues [nucleotide binding] 1129794005384 MT-A70; Region: MT-A70; cl01947 1129794005385 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1129794005386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794005387 non-specific DNA binding site [nucleotide binding]; other site 1129794005388 salt bridge; other site 1129794005389 sequence-specific DNA binding site [nucleotide binding]; other site 1129794005390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794005391 non-specific DNA binding site [nucleotide binding]; other site 1129794005392 salt bridge; other site 1129794005393 sequence-specific DNA binding site [nucleotide binding]; other site 1129794005394 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 1129794005395 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1129794005396 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1129794005397 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1129794005398 cofactor binding site; other site 1129794005399 DNA binding site [nucleotide binding] 1129794005400 substrate interaction site [chemical binding]; other site 1129794005401 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1129794005402 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 1129794005403 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1129794005404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794005405 non-specific DNA binding site [nucleotide binding]; other site 1129794005406 salt bridge; other site 1129794005407 sequence-specific DNA binding site [nucleotide binding]; other site 1129794005408 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1129794005409 Lysis protein S; Region: Lysis_S; pfam04971 1129794005410 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1129794005411 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 1129794005412 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1129794005413 gpW; Region: gpW; pfam02831 1129794005414 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1129794005415 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1129794005416 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1129794005417 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1129794005418 tandem repeat interface [polypeptide binding]; other site 1129794005419 oligomer interface [polypeptide binding]; other site 1129794005420 active site residues [active] 1129794005421 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1129794005422 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1129794005423 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1129794005424 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 1129794005425 Phage-related minor tail protein [Function unknown]; Region: COG5281 1129794005426 tape measure domain; Region: tape_meas_nterm; TIGR02675 1129794005427 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1129794005428 Protein of unknown function (DUF3080); Region: DUF3080; pfam11279 1129794005429 pteridine reductase; Provisional; Region: PRK09135 1129794005430 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 1129794005431 NADP binding site [chemical binding]; other site 1129794005432 substrate binding pocket [chemical binding]; other site 1129794005433 active site 1129794005434 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1129794005435 Phosphotransferase enzyme family; Region: APH; pfam01636 1129794005436 active site 1129794005437 ATP binding site [chemical binding]; other site 1129794005438 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 1129794005439 putative lipid binding site [chemical binding]; other site 1129794005440 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1129794005441 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1129794005442 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1129794005443 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1129794005444 active site 1129794005445 dimer interface [polypeptide binding]; other site 1129794005446 motif 1; other site 1129794005447 motif 2; other site 1129794005448 motif 3; other site 1129794005449 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1129794005450 anticodon binding site; other site 1129794005451 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1129794005452 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1129794005453 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1129794005454 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1129794005455 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1129794005456 23S rRNA binding site [nucleotide binding]; other site 1129794005457 L21 binding site [polypeptide binding]; other site 1129794005458 L13 binding site [polypeptide binding]; other site 1129794005459 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1129794005460 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1129794005461 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1129794005462 dimer interface [polypeptide binding]; other site 1129794005463 motif 1; other site 1129794005464 active site 1129794005465 motif 2; other site 1129794005466 motif 3; other site 1129794005467 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1129794005468 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1129794005469 putative tRNA-binding site [nucleotide binding]; other site 1129794005470 B3/4 domain; Region: B3_4; pfam03483 1129794005471 tRNA synthetase B5 domain; Region: B5; smart00874 1129794005472 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1129794005473 dimer interface [polypeptide binding]; other site 1129794005474 motif 1; other site 1129794005475 motif 3; other site 1129794005476 motif 2; other site 1129794005477 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1129794005478 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1129794005479 IHF dimer interface [polypeptide binding]; other site 1129794005480 IHF - DNA interface [nucleotide binding]; other site 1129794005481 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1129794005482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1129794005483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794005484 homodimer interface [polypeptide binding]; other site 1129794005485 catalytic residue [active] 1129794005486 NRDE protein; Region: NRDE; cl01315 1129794005487 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1129794005488 phosphopeptide binding site; other site 1129794005489 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1129794005490 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1129794005491 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 1129794005492 putative acyl-acceptor binding pocket; other site 1129794005493 hypothetical protein; Provisional; Region: PRK05939 1129794005494 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794005495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794005496 catalytic residue [active] 1129794005497 OsmC-like protein; Region: OsmC; cl00767 1129794005498 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1129794005499 S1 domain; Region: S1_2; pfam13509 1129794005500 S1 domain; Region: S1_2; pfam13509 1129794005501 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1129794005502 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1129794005503 homodimer interface [polypeptide binding]; other site 1129794005504 substrate-cofactor binding pocket; other site 1129794005505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794005506 catalytic residue [active] 1129794005507 alanine racemase; Reviewed; Region: alr; PRK00053 1129794005508 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1129794005509 active site 1129794005510 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1129794005511 substrate binding site [chemical binding]; other site 1129794005512 catalytic residues [active] 1129794005513 dimer interface [polypeptide binding]; other site 1129794005514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794005515 S-adenosylmethionine binding site [chemical binding]; other site 1129794005516 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1129794005517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794005518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1129794005519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794005520 active site 1129794005521 phosphorylation site [posttranslational modification] 1129794005522 intermolecular recognition site; other site 1129794005523 dimerization interface [polypeptide binding]; other site 1129794005524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794005525 DNA binding residues [nucleotide binding] 1129794005526 dimerization interface [polypeptide binding]; other site 1129794005527 adenosine deaminase; Provisional; Region: PRK09358 1129794005528 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1129794005529 active site 1129794005530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1129794005531 DNA binding site [nucleotide binding] 1129794005532 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794005533 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794005534 Integrase core domain; Region: rve; pfam00665 1129794005535 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1129794005536 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1129794005537 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1129794005538 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1129794005539 Part of AAA domain; Region: AAA_19; pfam13245 1129794005540 Family description; Region: UvrD_C_2; pfam13538 1129794005541 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1129794005542 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1129794005543 AAA domain; Region: AAA_30; pfam13604 1129794005544 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1129794005545 Family description; Region: UvrD_C_2; pfam13538 1129794005546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1129794005547 active site 1129794005548 Int/Topo IB signature motif; other site 1129794005549 DNA binding site [nucleotide binding] 1129794005550 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1129794005551 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1129794005552 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1129794005553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005554 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1129794005555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794005556 N-terminal plug; other site 1129794005557 ligand-binding site [chemical binding]; other site 1129794005558 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1129794005559 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1129794005560 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1129794005561 Transposase IS200 like; Region: Y1_Tnp; cl00848 1129794005562 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1129794005563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794005564 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1129794005565 MAPEG family; Region: MAPEG; cl09190 1129794005566 aspartate racemase; Region: asp_race; TIGR00035 1129794005567 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1129794005568 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1129794005569 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1129794005570 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1129794005571 active site 1129794005572 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1129794005573 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1129794005574 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1129794005575 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1129794005576 active site 1129794005577 substrate binding site [chemical binding]; other site 1129794005578 cosubstrate binding site; other site 1129794005579 catalytic site [active] 1129794005580 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1129794005581 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1129794005582 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1129794005583 dimerization interface [polypeptide binding]; other site 1129794005584 putative ATP binding site [chemical binding]; other site 1129794005585 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1129794005586 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1129794005587 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 1129794005588 Walker A motif; other site 1129794005589 ATP binding site [chemical binding]; other site 1129794005590 Walker B motif; other site 1129794005591 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 1129794005592 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1129794005593 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1129794005594 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1129794005595 ArsC family; Region: ArsC; pfam03960 1129794005596 catalytic residues [active] 1129794005597 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1129794005598 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794005599 catalytic residues [active] 1129794005600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1129794005601 binding surface 1129794005602 TPR motif; other site 1129794005603 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1129794005604 Peptidase family M48; Region: Peptidase_M48; pfam01435 1129794005605 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1129794005606 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1129794005607 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1129794005608 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1129794005609 catalytic triad [active] 1129794005610 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1129794005611 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1129794005612 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1129794005613 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1129794005614 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1129794005615 dimer interface [polypeptide binding]; other site 1129794005616 active site 1129794005617 catalytic residue [active] 1129794005618 lipoprotein; Provisional; Region: PRK11679 1129794005619 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1129794005620 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1129794005621 ATP binding site [chemical binding]; other site 1129794005622 active site 1129794005623 substrate binding site [chemical binding]; other site 1129794005624 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1129794005625 dimer interface [polypeptide binding]; other site 1129794005626 putative radical transfer pathway; other site 1129794005627 diiron center [ion binding]; other site 1129794005628 tyrosyl radical; other site 1129794005629 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1129794005630 ATP cone domain; Region: ATP-cone; pfam03477 1129794005631 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1129794005632 active site 1129794005633 dimer interface [polypeptide binding]; other site 1129794005634 catalytic residues [active] 1129794005635 effector binding site; other site 1129794005636 R2 peptide binding site; other site 1129794005637 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1129794005638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794005639 active site 1129794005640 motif I; other site 1129794005641 motif II; other site 1129794005642 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1129794005643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794005644 S-adenosylmethionine binding site [chemical binding]; other site 1129794005645 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1129794005646 CAP-like domain; other site 1129794005647 active site 1129794005648 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1129794005649 primary dimer interface [polypeptide binding]; other site 1129794005650 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1129794005651 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1129794005652 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1129794005653 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1129794005654 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1129794005655 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1129794005656 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1129794005657 homodimer interface [polypeptide binding]; other site 1129794005658 substrate-cofactor binding pocket; other site 1129794005659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794005660 catalytic residue [active] 1129794005661 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1129794005662 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1129794005663 hinge; other site 1129794005664 active site 1129794005665 cytidylate kinase; Provisional; Region: cmk; PRK00023 1129794005666 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1129794005667 CMP-binding site; other site 1129794005668 The sites determining sugar specificity; other site 1129794005669 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1129794005670 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1129794005671 RNA binding site [nucleotide binding]; other site 1129794005672 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1129794005673 RNA binding site [nucleotide binding]; other site 1129794005674 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1129794005675 RNA binding site [nucleotide binding]; other site 1129794005676 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1129794005677 RNA binding site [nucleotide binding]; other site 1129794005678 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1129794005679 RNA binding site [nucleotide binding]; other site 1129794005680 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1129794005681 RNA binding site [nucleotide binding]; other site 1129794005682 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1129794005683 IHF dimer interface [polypeptide binding]; other site 1129794005684 IHF - DNA interface [nucleotide binding]; other site 1129794005685 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1129794005686 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1129794005687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794005688 binding surface 1129794005689 TPR motif; other site 1129794005690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794005691 binding surface 1129794005692 TPR motif; other site 1129794005693 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1129794005694 active site 1129794005695 dimer interface [polypeptide binding]; other site 1129794005696 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1129794005697 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1129794005698 hexamer interface [polypeptide binding]; other site 1129794005699 ligand binding site [chemical binding]; other site 1129794005700 putative active site [active] 1129794005701 NAD(P) binding site [chemical binding]; other site 1129794005702 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1129794005703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1129794005704 putative DNA binding site [nucleotide binding]; other site 1129794005705 putative Zn2+ binding site [ion binding]; other site 1129794005706 AsnC family; Region: AsnC_trans_reg; pfam01037 1129794005707 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1129794005708 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1129794005709 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1129794005710 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1129794005711 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1129794005712 recombination factor protein RarA; Reviewed; Region: PRK13342 1129794005713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794005714 Walker A motif; other site 1129794005715 ATP binding site [chemical binding]; other site 1129794005716 Walker B motif; other site 1129794005717 arginine finger; other site 1129794005718 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1129794005719 CrcB-like protein; Region: CRCB; cl09114 1129794005720 seryl-tRNA synthetase; Provisional; Region: PRK05431 1129794005721 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1129794005722 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1129794005723 dimer interface [polypeptide binding]; other site 1129794005724 active site 1129794005725 motif 1; other site 1129794005726 motif 2; other site 1129794005727 motif 3; other site 1129794005728 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1129794005729 motif 1; other site 1129794005730 dimer interface [polypeptide binding]; other site 1129794005731 active site 1129794005732 motif 2; other site 1129794005733 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1129794005734 motif 3; other site 1129794005735 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1129794005736 DsrC like protein; Region: DsrC; pfam04358 1129794005737 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1129794005738 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 1129794005739 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 1129794005740 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 1129794005741 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1129794005742 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1129794005743 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1129794005744 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1129794005745 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1129794005746 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1129794005747 putative metal binding site [ion binding]; other site 1129794005748 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1129794005749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794005750 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1129794005751 putative dimerization interface [polypeptide binding]; other site 1129794005752 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1129794005753 30S subunit binding site; other site 1129794005754 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1129794005755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794005756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794005757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794005758 response regulator; Provisional; Region: PRK09483 1129794005759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794005760 active site 1129794005761 phosphorylation site [posttranslational modification] 1129794005762 intermolecular recognition site; other site 1129794005763 dimerization interface [polypeptide binding]; other site 1129794005764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794005765 DNA binding residues [nucleotide binding] 1129794005766 dimerization interface [polypeptide binding]; other site 1129794005767 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1129794005768 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1129794005769 GIY-YIG motif/motif A; other site 1129794005770 active site 1129794005771 catalytic site [active] 1129794005772 putative DNA binding site [nucleotide binding]; other site 1129794005773 metal binding site [ion binding]; metal-binding site 1129794005774 UvrB/uvrC motif; Region: UVR; pfam02151 1129794005775 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1129794005776 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794005777 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1129794005778 Peptidase family M28; Region: Peptidase_M28; pfam04389 1129794005779 metal binding site [ion binding]; metal-binding site 1129794005780 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1129794005781 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1129794005782 TrkA-N domain; Region: TrkA_N; pfam02254 1129794005783 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1129794005784 nudix motif; other site 1129794005785 ABC1 family; Region: ABC1; cl17513 1129794005786 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1129794005787 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1129794005788 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1129794005789 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794005790 ATP binding site [chemical binding]; other site 1129794005791 Mg++ binding site [ion binding]; other site 1129794005792 motif III; other site 1129794005793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794005794 nucleotide binding region [chemical binding]; other site 1129794005795 ATP-binding site [chemical binding]; other site 1129794005796 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1129794005797 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1129794005798 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1129794005799 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1129794005800 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1129794005801 Ligand Binding Site [chemical binding]; other site 1129794005802 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1129794005803 Ligand Binding Site [chemical binding]; other site 1129794005804 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 1129794005805 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1129794005806 substrate binding pocket [chemical binding]; other site 1129794005807 membrane-bound complex binding site; other site 1129794005808 hinge residues; other site 1129794005809 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1129794005810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1129794005811 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1129794005812 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794005813 ATP binding site [chemical binding]; other site 1129794005814 Mg++ binding site [ion binding]; other site 1129794005815 motif III; other site 1129794005816 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794005817 nucleotide binding region [chemical binding]; other site 1129794005818 ATP-binding site [chemical binding]; other site 1129794005819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1129794005820 short chain dehydrogenase; Provisional; Region: PRK06181 1129794005821 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 1129794005822 putative NAD(P) binding site [chemical binding]; other site 1129794005823 homotetramer interface [polypeptide binding]; other site 1129794005824 active site 1129794005825 homodimer interface [polypeptide binding]; other site 1129794005826 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 1129794005827 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1129794005828 dimer interface [polypeptide binding]; other site 1129794005829 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794005830 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794005831 catalytic residue [active] 1129794005832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794005833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1129794005834 nucleotide binding site [chemical binding]; other site 1129794005835 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1129794005836 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1129794005837 nucleotide binding site [chemical binding]; other site 1129794005838 SBD interface [polypeptide binding]; other site 1129794005839 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794005840 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1129794005841 C-terminal domain interface [polypeptide binding]; other site 1129794005842 GSH binding site (G-site) [chemical binding]; other site 1129794005843 dimer interface [polypeptide binding]; other site 1129794005844 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1129794005845 N-terminal domain interface [polypeptide binding]; other site 1129794005846 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794005847 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1129794005848 C-terminal domain interface [polypeptide binding]; other site 1129794005849 GSH binding site (G-site) [chemical binding]; other site 1129794005850 dimer interface [polypeptide binding]; other site 1129794005851 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794005852 N-terminal domain interface [polypeptide binding]; other site 1129794005853 dimer interface [polypeptide binding]; other site 1129794005854 substrate binding pocket (H-site) [chemical binding]; other site 1129794005855 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794005856 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1129794005857 putative C-terminal domain interface [polypeptide binding]; other site 1129794005858 putative GSH binding site (G-site) [chemical binding]; other site 1129794005859 putative dimer interface [polypeptide binding]; other site 1129794005860 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794005861 N-terminal domain interface [polypeptide binding]; other site 1129794005862 dimer interface [polypeptide binding]; other site 1129794005863 substrate binding pocket (H-site) [chemical binding]; other site 1129794005864 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1129794005865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794005866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794005867 GAF domain; Region: GAF_3; pfam13492 1129794005868 GAF domain; Region: GAF_2; pfam13185 1129794005869 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1129794005870 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794005871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794005872 metal binding site [ion binding]; metal-binding site 1129794005873 active site 1129794005874 I-site; other site 1129794005875 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1129794005876 Homeodomain-like domain; Region: HTH_23; pfam13384 1129794005877 Winged helix-turn helix; Region: HTH_29; pfam13551 1129794005878 Winged helix-turn helix; Region: HTH_33; pfam13592 1129794005879 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1129794005880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1129794005881 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1129794005882 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1129794005883 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1129794005884 NAD binding site [chemical binding]; other site 1129794005885 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1129794005886 Cation efflux family; Region: Cation_efflux; cl00316 1129794005887 Cation efflux family; Region: Cation_efflux; cl00316 1129794005888 Cation efflux family; Region: Cation_efflux; cl00316 1129794005889 Cytochrome c; Region: Cytochrom_C; cl11414 1129794005890 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1129794005891 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 1129794005892 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1129794005893 active site 1129794005894 catalytic site [active] 1129794005895 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1129794005896 Putative esterase; Region: Esterase; pfam00756 1129794005897 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1129794005898 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1129794005899 CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY. CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598 1129794005900 putative active site [active] 1129794005901 putative catalytic site [active] 1129794005902 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1129794005903 MOSC domain; Region: MOSC; pfam03473 1129794005904 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1129794005905 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1129794005906 putative efflux protein, MATE family; Region: matE; TIGR00797 1129794005907 cation binding site [ion binding]; other site 1129794005908 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1129794005909 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1129794005910 dimer interface [polypeptide binding]; other site 1129794005911 putative functional site; other site 1129794005912 putative MPT binding site; other site 1129794005913 TraB family; Region: TraB; pfam01963 1129794005914 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1129794005915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794005916 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1129794005917 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1129794005918 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1129794005919 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1129794005920 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1129794005921 [4Fe-4S] binding site [ion binding]; other site 1129794005922 molybdopterin cofactor binding site; other site 1129794005923 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1129794005924 molybdopterin cofactor binding site; other site 1129794005925 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1129794005926 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1129794005927 active site 1129794005928 SAM binding site [chemical binding]; other site 1129794005929 homodimer interface [polypeptide binding]; other site 1129794005930 hypothetical protein; Validated; Region: PRK09071 1129794005931 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1129794005932 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1129794005933 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794005934 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 1129794005935 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1129794005936 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1129794005937 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1129794005938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794005939 motif II; other site 1129794005940 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1129794005941 Predicted membrane protein [Function unknown]; Region: COG3235 1129794005942 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1129794005943 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1129794005944 putative catalytic site [active] 1129794005945 putative phosphate binding site [ion binding]; other site 1129794005946 active site 1129794005947 metal binding site A [ion binding]; metal-binding site 1129794005948 DNA binding site [nucleotide binding] 1129794005949 putative AP binding site [nucleotide binding]; other site 1129794005950 putative metal binding site B [ion binding]; other site 1129794005951 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1129794005952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1129794005953 MULE transposase domain; Region: MULE; pfam10551 1129794005954 Integrase core domain; Region: rve; pfam00665 1129794005955 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1129794005956 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1129794005957 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1129794005958 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 1129794005959 Predicted methyltransferase [General function prediction only]; Region: COG4798 1129794005960 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1129794005961 S-adenosylmethionine binding site [chemical binding]; other site 1129794005962 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1129794005963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794005964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794005965 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1129794005966 substrate binding pocket [chemical binding]; other site 1129794005967 dimerization interface [polypeptide binding]; other site 1129794005968 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1129794005969 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1129794005970 Nucleoside recognition; Region: Gate; pfam07670 1129794005971 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1129794005972 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1129794005973 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1129794005974 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1129794005975 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1129794005976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794005977 Walker A/P-loop; other site 1129794005978 ATP binding site [chemical binding]; other site 1129794005979 Q-loop/lid; other site 1129794005980 ABC transporter signature motif; other site 1129794005981 Walker B; other site 1129794005982 D-loop; other site 1129794005983 H-loop/switch region; other site 1129794005984 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1129794005985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1129794005986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794005987 Walker A/P-loop; other site 1129794005988 ATP binding site [chemical binding]; other site 1129794005989 Q-loop/lid; other site 1129794005990 ABC transporter signature motif; other site 1129794005991 Walker B; other site 1129794005992 D-loop; other site 1129794005993 H-loop/switch region; other site 1129794005994 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1129794005995 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1129794005996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794005997 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1129794005998 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 1129794005999 NADP binding site [chemical binding]; other site 1129794006000 active site 1129794006001 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1129794006002 classical (c) SDRs; Region: SDR_c; cd05233 1129794006003 NAD(P) binding site [chemical binding]; other site 1129794006004 active site 1129794006005 enoyl-CoA hydratase; Provisional; Region: PRK06142 1129794006006 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794006007 substrate binding site [chemical binding]; other site 1129794006008 oxyanion hole (OAH) forming residues; other site 1129794006009 trimer interface [polypeptide binding]; other site 1129794006010 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1129794006011 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1129794006012 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1129794006013 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1129794006014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794006015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794006016 Coenzyme A binding pocket [chemical binding]; other site 1129794006017 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1129794006018 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1129794006019 putative active site [active] 1129794006020 Zn binding site [ion binding]; other site 1129794006021 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1129794006022 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1129794006023 active site 1129794006024 catalytic tetrad [active] 1129794006025 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1129794006026 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1129794006027 SpoVR family protein; Provisional; Region: PRK11767 1129794006028 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1129794006029 hypothetical protein; Provisional; Region: PRK05325 1129794006030 PrkA family serine protein kinase; Provisional; Region: PRK15455 1129794006031 AAA ATPase domain; Region: AAA_16; pfam13191 1129794006032 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1129794006033 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1129794006034 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1129794006035 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1129794006036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1129794006037 Divalent cation transporter; Region: MgtE; pfam01769 1129794006038 Penicillin amidase; Region: Penicil_amidase; pfam01804 1129794006039 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1129794006040 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1129794006041 active site 1129794006042 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1129794006043 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1129794006044 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1129794006045 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1129794006046 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1129794006047 active site clefts [active] 1129794006048 zinc binding site [ion binding]; other site 1129794006049 dimer interface [polypeptide binding]; other site 1129794006050 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1129794006051 Lumazine binding domain; Region: Lum_binding; pfam00677 1129794006052 Lumazine binding domain; Region: Lum_binding; pfam00677 1129794006053 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794006054 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1129794006055 ATP binding site [chemical binding]; other site 1129794006056 Mg++ binding site [ion binding]; other site 1129794006057 motif III; other site 1129794006058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794006059 nucleotide binding region [chemical binding]; other site 1129794006060 ATP-binding site [chemical binding]; other site 1129794006061 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1129794006062 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1129794006063 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1129794006064 Switch I; other site 1129794006065 Switch II; other site 1129794006066 septum formation inhibitor; Reviewed; Region: minC; PRK04804 1129794006067 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1129794006068 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1129794006069 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 1129794006070 spermidine synthase; Provisional; Region: PRK03612 1129794006071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794006072 S-adenosylmethionine binding site [chemical binding]; other site 1129794006073 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1129794006074 CoenzymeA binding site [chemical binding]; other site 1129794006075 subunit interaction site [polypeptide binding]; other site 1129794006076 PHB binding site; other site 1129794006077 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1129794006078 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794006079 Helix-turn-helix domain; Region: HTH_18; pfam12833 1129794006080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794006081 ferredoxin-NADP+ reductase; Region: PLN02852 1129794006082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794006083 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1129794006084 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1129794006085 putative [Fe4-S4] binding site [ion binding]; other site 1129794006086 putative molybdopterin cofactor binding site [chemical binding]; other site 1129794006087 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1129794006088 putative molybdopterin cofactor binding site; other site 1129794006089 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1129794006090 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1129794006091 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794006092 acyl-activating enzyme (AAE) consensus motif; other site 1129794006093 AMP binding site [chemical binding]; other site 1129794006094 active site 1129794006095 CoA binding site [chemical binding]; other site 1129794006096 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1129794006097 Walker A motif; other site 1129794006098 ATP binding site [chemical binding]; other site 1129794006099 Walker B motif; other site 1129794006100 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1129794006101 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1129794006102 active site 1129794006103 metal binding site [ion binding]; metal-binding site 1129794006104 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 1129794006105 kynureninase; Region: kynureninase; TIGR01814 1129794006106 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794006107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794006108 catalytic residue [active] 1129794006109 Domain of unknown function (DUF3336); Region: DUF3336; pfam11815 1129794006110 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1129794006111 active site 1129794006112 nucleophile elbow; other site 1129794006113 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1129794006114 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794006115 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794006116 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794006117 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794006118 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1129794006119 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1129794006120 homodimer interface [polypeptide binding]; other site 1129794006121 substrate-cofactor binding pocket; other site 1129794006122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794006123 catalytic residue [active] 1129794006124 DTW domain; Region: DTW; cl01221 1129794006125 DTW domain; Region: DTW; cl01221 1129794006126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1129794006127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794006128 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1129794006129 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1129794006130 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1129794006131 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1129794006132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794006133 active site 1129794006134 phosphorylation site [posttranslational modification] 1129794006135 intermolecular recognition site; other site 1129794006136 dimerization interface [polypeptide binding]; other site 1129794006137 ANTAR domain; Region: ANTAR; pfam03861 1129794006138 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1129794006139 NMT1-like family; Region: NMT1_2; pfam13379 1129794006140 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1129794006141 NMT1-like family; Region: NMT1_2; pfam13379 1129794006142 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1129794006143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794006144 dimer interface [polypeptide binding]; other site 1129794006145 conserved gate region; other site 1129794006146 putative PBP binding loops; other site 1129794006147 ABC-ATPase subunit interface; other site 1129794006148 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1129794006149 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1129794006150 Walker A/P-loop; other site 1129794006151 ATP binding site [chemical binding]; other site 1129794006152 Q-loop/lid; other site 1129794006153 ABC transporter signature motif; other site 1129794006154 Walker B; other site 1129794006155 D-loop; other site 1129794006156 H-loop/switch region; other site 1129794006157 Predicted membrane protein [Function unknown]; Region: COG2259 1129794006158 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1129794006159 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1129794006160 RNA/DNA hybrid binding site [nucleotide binding]; other site 1129794006161 active site 1129794006162 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1129794006163 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1129794006164 active site 1129794006165 catalytic site [active] 1129794006166 substrate binding site [chemical binding]; other site 1129794006167 TIGR03503 family protein; Region: TIGR03503 1129794006168 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1129794006169 Domain of unknown function DUF21; Region: DUF21; pfam01595 1129794006170 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1129794006171 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1129794006172 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1129794006173 Walker A/P-loop; other site 1129794006174 ATP binding site [chemical binding]; other site 1129794006175 Q-loop/lid; other site 1129794006176 ABC transporter signature motif; other site 1129794006177 Walker B; other site 1129794006178 D-loop; other site 1129794006179 H-loop/switch region; other site 1129794006180 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1129794006181 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794006182 FtsX-like permease family; Region: FtsX; pfam02687 1129794006183 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1129794006184 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1129794006185 putative molybdopterin cofactor binding site [chemical binding]; other site 1129794006186 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1129794006187 putative molybdopterin cofactor binding site; other site 1129794006188 elongation factor P; Provisional; Region: PRK04542 1129794006189 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1129794006190 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1129794006191 RNA binding site [nucleotide binding]; other site 1129794006192 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1129794006193 RNA binding site [nucleotide binding]; other site 1129794006194 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1129794006195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1129794006196 DEAD_2; Region: DEAD_2; pfam06733 1129794006197 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1129794006198 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1129794006199 Glycoprotease family; Region: Peptidase_M22; pfam00814 1129794006200 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 1129794006201 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794006202 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1129794006203 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1129794006204 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794006205 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1129794006206 acyl-activating enzyme (AAE) consensus motif; other site 1129794006207 putative AMP binding site [chemical binding]; other site 1129794006208 putative active site [active] 1129794006209 putative CoA binding site [chemical binding]; other site 1129794006210 ribonuclease D; Provisional; Region: PRK10829 1129794006211 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1129794006212 catalytic site [active] 1129794006213 putative active site [active] 1129794006214 putative substrate binding site [chemical binding]; other site 1129794006215 HRDC domain; Region: HRDC; pfam00570 1129794006216 YcgL domain; Region: YcgL; pfam05166 1129794006217 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1129794006218 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794006219 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1129794006220 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1129794006221 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1129794006222 hypothetical protein; Provisional; Region: PRK05170 1129794006223 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1129794006224 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1129794006225 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1129794006226 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1129794006227 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1129794006228 succinylarginine dihydrolase; Provisional; Region: PRK13281 1129794006229 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1129794006230 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1129794006231 active site 1129794006232 interdomain interaction site; other site 1129794006233 putative metal-binding site [ion binding]; other site 1129794006234 nucleotide binding site [chemical binding]; other site 1129794006235 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1129794006236 domain I; other site 1129794006237 DNA binding groove [nucleotide binding] 1129794006238 phosphate binding site [ion binding]; other site 1129794006239 domain II; other site 1129794006240 domain III; other site 1129794006241 nucleotide binding site [chemical binding]; other site 1129794006242 catalytic site [active] 1129794006243 domain IV; other site 1129794006244 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1129794006245 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1129794006246 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1129794006247 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1129794006248 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1129794006249 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1129794006250 active site 1129794006251 catalytic site [active] 1129794006252 substrate binding site [chemical binding]; other site 1129794006253 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1129794006254 Phage shock protein B; Region: PspB; cl05946 1129794006255 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794006256 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1129794006257 FtsX-like permease family; Region: FtsX; pfam02687 1129794006258 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794006259 FtsX-like permease family; Region: FtsX; pfam02687 1129794006260 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794006261 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1129794006262 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1129794006263 Walker A/P-loop; other site 1129794006264 ATP binding site [chemical binding]; other site 1129794006265 Q-loop/lid; other site 1129794006266 ABC transporter signature motif; other site 1129794006267 Walker B; other site 1129794006268 D-loop; other site 1129794006269 H-loop/switch region; other site 1129794006270 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794006271 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794006272 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794006273 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794006274 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1129794006275 FtsX-like permease family; Region: FtsX; pfam02687 1129794006276 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1129794006277 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794006278 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794006279 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794006280 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794006281 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1129794006282 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1129794006283 putative [Fe4-S4] binding site [ion binding]; other site 1129794006284 putative molybdopterin cofactor binding site [chemical binding]; other site 1129794006285 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1129794006286 putative molybdopterin cofactor binding site; other site 1129794006287 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 1129794006288 tetramerization interface [polypeptide binding]; other site 1129794006289 substrate binding pocket [chemical binding]; other site 1129794006290 catalytic residues [active] 1129794006291 inhibitor binding sites; inhibition site 1129794006292 NADP(H) binding site [chemical binding]; other site 1129794006293 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1129794006294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1129794006295 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1129794006296 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1129794006297 active site 1129794006298 catalytic tetrad [active] 1129794006299 tellurium resistance terB-like protein; Region: terB_like; cd07177 1129794006300 metal binding site [ion binding]; metal-binding site 1129794006301 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794006302 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794006303 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794006304 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794006305 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794006306 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1129794006307 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1129794006308 RNA polymerase sigma factor; Provisional; Region: PRK12513 1129794006309 hypothetical protein; Validated; Region: PRK00124 1129794006310 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1129794006311 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794006312 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794006313 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1129794006314 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794006315 ATP binding site [chemical binding]; other site 1129794006316 Mg++ binding site [ion binding]; other site 1129794006317 motif III; other site 1129794006318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794006319 nucleotide binding region [chemical binding]; other site 1129794006320 ATP-binding site [chemical binding]; other site 1129794006321 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1129794006322 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1129794006323 ribonuclease E; Reviewed; Region: rne; PRK10811 1129794006324 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1129794006325 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1129794006326 RNA binding surface [nucleotide binding]; other site 1129794006327 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1129794006328 active site 1129794006329 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1129794006330 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1129794006331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794006332 Maf-like protein; Region: Maf; pfam02545 1129794006333 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1129794006334 active site 1129794006335 dimer interface [polypeptide binding]; other site 1129794006336 hypothetical protein; Provisional; Region: PRK11193 1129794006337 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1129794006338 putative phosphate acyltransferase; Provisional; Region: PRK05331 1129794006339 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1129794006340 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1129794006341 dimer interface [polypeptide binding]; other site 1129794006342 active site 1129794006343 CoA binding pocket [chemical binding]; other site 1129794006344 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1129794006345 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1129794006346 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1129794006347 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1129794006348 NAD(P) binding site [chemical binding]; other site 1129794006349 homotetramer interface [polypeptide binding]; other site 1129794006350 homodimer interface [polypeptide binding]; other site 1129794006351 active site 1129794006352 acyl carrier protein; Provisional; Region: acpP; PRK00982 1129794006353 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1129794006354 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1129794006355 dimer interface [polypeptide binding]; other site 1129794006356 active site 1129794006357 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1129794006358 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1129794006359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794006360 catalytic residue [active] 1129794006361 YceG-like family; Region: YceG; pfam02618 1129794006362 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1129794006363 dimerization interface [polypeptide binding]; other site 1129794006364 thymidylate kinase; Validated; Region: tmk; PRK00698 1129794006365 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1129794006366 TMP-binding site; other site 1129794006367 ATP-binding site [chemical binding]; other site 1129794006368 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1129794006369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794006370 Walker A motif; other site 1129794006371 ATP binding site [chemical binding]; other site 1129794006372 Walker B motif; other site 1129794006373 arginine finger; other site 1129794006374 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1129794006375 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1129794006376 active site 1129794006377 hypothetical protein; Provisional; Region: PRK04233 1129794006378 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 1129794006379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794006380 Zn2+ binding site [ion binding]; other site 1129794006381 Mg2+ binding site [ion binding]; other site 1129794006382 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1129794006383 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794006384 Zn2+ binding site [ion binding]; other site 1129794006385 Mg2+ binding site [ion binding]; other site 1129794006386 aminotransferase AlaT; Validated; Region: PRK09265 1129794006387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1129794006388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794006389 homodimer interface [polypeptide binding]; other site 1129794006390 catalytic residue [active] 1129794006391 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1129794006392 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1129794006393 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1129794006394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794006395 S-adenosylmethionine binding site [chemical binding]; other site 1129794006396 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1129794006397 catalytic residues [active] 1129794006398 dimer interface [polypeptide binding]; other site 1129794006399 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1129794006400 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1129794006401 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1129794006402 exonuclease I; Provisional; Region: sbcB; PRK11779 1129794006403 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1129794006404 active site 1129794006405 catalytic site [active] 1129794006406 substrate binding site [chemical binding]; other site 1129794006407 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1129794006408 FOG: CBS domain [General function prediction only]; Region: COG0517 1129794006409 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 1129794006410 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1129794006411 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794006412 ATP binding site [chemical binding]; other site 1129794006413 putative Mg++ binding site [ion binding]; other site 1129794006414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794006415 nucleotide binding region [chemical binding]; other site 1129794006416 ATP-binding site [chemical binding]; other site 1129794006417 Helicase associated domain (HA2); Region: HA2; pfam04408 1129794006418 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1129794006419 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1129794006420 PilZ domain; Region: PilZ; pfam07238 1129794006421 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1129794006422 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1129794006423 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1129794006424 putative RNA binding site [nucleotide binding]; other site 1129794006425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794006426 S-adenosylmethionine binding site [chemical binding]; other site 1129794006427 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1129794006428 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1129794006429 NAD(P) binding site [chemical binding]; other site 1129794006430 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1129794006431 malate synthase G; Provisional; Region: PRK02999 1129794006432 active site 1129794006433 NAD-dependent deacetylase; Provisional; Region: PRK00481 1129794006434 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1129794006435 NAD+ binding site [chemical binding]; other site 1129794006436 substrate binding site [chemical binding]; other site 1129794006437 Zn binding site [ion binding]; other site 1129794006438 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1129794006439 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1129794006440 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1129794006441 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 1129794006442 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1129794006443 hypothetical protein; Provisional; Region: PRK10279 1129794006444 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1129794006445 active site 1129794006446 nucleophile elbow; other site 1129794006447 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1129794006448 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1129794006449 Ligand Binding Site [chemical binding]; other site 1129794006450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794006451 Walker A/P-loop; other site 1129794006452 ATP binding site [chemical binding]; other site 1129794006453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794006454 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1129794006455 Q-loop/lid; other site 1129794006456 ABC transporter signature motif; other site 1129794006457 Walker B; other site 1129794006458 D-loop; other site 1129794006459 H-loop/switch region; other site 1129794006460 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794006461 universal stress protein UspE; Provisional; Region: PRK11175 1129794006462 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1129794006463 Ligand Binding Site [chemical binding]; other site 1129794006464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1129794006465 Ligand Binding Site [chemical binding]; other site 1129794006466 Family description; Region: DsbD_2; pfam13386 1129794006467 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1129794006468 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1129794006469 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1129794006470 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1129794006471 metal-binding site [ion binding] 1129794006472 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1129794006473 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1129794006474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1129794006475 FixH; Region: FixH; pfam05751 1129794006476 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1129794006477 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1129794006478 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1129794006479 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1129794006480 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1129794006481 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1129794006482 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1129794006483 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1129794006484 Low-spin heme binding site [chemical binding]; other site 1129794006485 Putative water exit pathway; other site 1129794006486 Binuclear center (active site) [active] 1129794006487 Putative proton exit pathway; other site 1129794006488 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1129794006489 heme binding site [chemical binding]; other site 1129794006490 ferroxidase pore; other site 1129794006491 ferroxidase diiron center [ion binding]; other site 1129794006492 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1129794006493 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1129794006494 heme binding site [chemical binding]; other site 1129794006495 ferroxidase pore; other site 1129794006496 ferroxidase diiron center [ion binding]; other site 1129794006497 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1129794006498 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1129794006499 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1129794006500 TrkA-N domain; Region: TrkA_N; pfam02254 1129794006501 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1129794006502 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 1129794006503 Int/Topo IB signature motif; other site 1129794006504 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1129794006505 Clp amino terminal domain; Region: Clp_N; pfam02861 1129794006506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794006507 Walker A motif; other site 1129794006508 ATP binding site [chemical binding]; other site 1129794006509 Walker B motif; other site 1129794006510 arginine finger; other site 1129794006511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794006512 Walker A motif; other site 1129794006513 ATP binding site [chemical binding]; other site 1129794006514 Walker B motif; other site 1129794006515 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1129794006516 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1129794006517 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 1129794006518 putative active site [active] 1129794006519 catalytic site [active] 1129794006520 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 1129794006521 putative active site [active] 1129794006522 catalytic site [active] 1129794006523 hypothetical protein; Provisional; Region: PRK05421 1129794006524 putative catalytic site [active] 1129794006525 putative metal binding site [ion binding]; other site 1129794006526 putative phosphate binding site [ion binding]; other site 1129794006527 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1129794006528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794006529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794006530 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1129794006531 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1129794006532 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1129794006533 tetramer interface [polypeptide binding]; other site 1129794006534 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1129794006535 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1129794006536 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1129794006537 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794006538 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794006539 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794006540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794006541 active site 1129794006542 phosphorylation site [posttranslational modification] 1129794006543 intermolecular recognition site; other site 1129794006544 dimerization interface [polypeptide binding]; other site 1129794006545 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794006546 DNA binding site [nucleotide binding] 1129794006547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794006548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794006549 dimer interface [polypeptide binding]; other site 1129794006550 phosphorylation site [posttranslational modification] 1129794006551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794006552 ATP binding site [chemical binding]; other site 1129794006553 Mg2+ binding site [ion binding]; other site 1129794006554 G-X-G motif; other site 1129794006555 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1129794006556 putative ligand binding site [chemical binding]; other site 1129794006557 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1129794006558 putative metal dependent hydrolase; Provisional; Region: PRK11598 1129794006559 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1129794006560 Sulfatase; Region: Sulfatase; pfam00884 1129794006561 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1129794006562 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1129794006563 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1129794006564 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 1129794006565 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1129794006566 Sulfatase; Region: Sulfatase; pfam00884 1129794006567 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1129794006568 PAS fold; Region: PAS_3; pfam08447 1129794006569 GAF domain; Region: GAF; pfam01590 1129794006570 GAF domain; Region: GAF_2; pfam13185 1129794006571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794006572 PAS domain; Region: PAS_9; pfam13426 1129794006573 putative active site [active] 1129794006574 heme pocket [chemical binding]; other site 1129794006575 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794006576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794006577 metal binding site [ion binding]; metal-binding site 1129794006578 active site 1129794006579 I-site; other site 1129794006580 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794006581 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1129794006582 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794006583 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794006584 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1129794006585 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1129794006586 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1129794006587 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1129794006588 FOG: CBS domain [General function prediction only]; Region: COG0517 1129794006589 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1129794006590 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1129794006591 active site residue [active] 1129794006592 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794006593 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1129794006594 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794006595 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794006596 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794006597 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1129794006598 dimerization interface [polypeptide binding]; other site 1129794006599 putative DNA binding site [nucleotide binding]; other site 1129794006600 putative Zn2+ binding site [ion binding]; other site 1129794006601 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1129794006602 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1129794006603 Ligand Binding Site [chemical binding]; other site 1129794006604 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1129794006605 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1129794006606 ligand binding site [chemical binding]; other site 1129794006607 flexible hinge region; other site 1129794006608 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1129794006609 putative switch regulator; other site 1129794006610 non-specific DNA interactions [nucleotide binding]; other site 1129794006611 DNA binding site [nucleotide binding] 1129794006612 sequence specific DNA binding site [nucleotide binding]; other site 1129794006613 putative cAMP binding site [chemical binding]; other site 1129794006614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794006615 putative active site [active] 1129794006616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794006617 dimer interface [polypeptide binding]; other site 1129794006618 phosphorylation site [posttranslational modification] 1129794006619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794006620 ATP binding site [chemical binding]; other site 1129794006621 Mg2+ binding site [ion binding]; other site 1129794006622 G-X-G motif; other site 1129794006623 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1129794006624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794006625 active site 1129794006626 phosphorylation site [posttranslational modification] 1129794006627 intermolecular recognition site; other site 1129794006628 dimerization interface [polypeptide binding]; other site 1129794006629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794006630 DNA binding residues [nucleotide binding] 1129794006631 dimerization interface [polypeptide binding]; other site 1129794006632 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794006633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794006634 active site 1129794006635 phosphorylation site [posttranslational modification] 1129794006636 intermolecular recognition site; other site 1129794006637 dimerization interface [polypeptide binding]; other site 1129794006638 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1129794006639 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1129794006640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1129794006641 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1129794006642 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1129794006643 active site 1 [active] 1129794006644 dimer interface [polypeptide binding]; other site 1129794006645 active site 2 [active] 1129794006646 Ribosome modulation factor; Region: RMF; pfam04957 1129794006647 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 1129794006648 GlyGly-CTERM domain; Region: GlyGly_CTERM; TIGR03501 1129794006649 ABC transporter ATPase component; Reviewed; Region: PRK11147 1129794006650 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794006651 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794006652 ABC transporter; Region: ABC_tran_2; pfam12848 1129794006653 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794006654 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1129794006655 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1129794006656 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1129794006657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1129794006658 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1129794006659 putative RNA binding site [nucleotide binding]; other site 1129794006660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794006661 S-adenosylmethionine binding site [chemical binding]; other site 1129794006662 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1129794006663 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1129794006664 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1129794006665 quinone interaction residues [chemical binding]; other site 1129794006666 active site 1129794006667 catalytic residues [active] 1129794006668 FMN binding site [chemical binding]; other site 1129794006669 substrate binding site [chemical binding]; other site 1129794006670 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1129794006671 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1129794006672 aminopeptidase N; Provisional; Region: pepN; PRK14015 1129794006673 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1129794006674 Zn binding site [ion binding]; other site 1129794006675 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1129794006676 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1129794006677 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1129794006678 Na2 binding site [ion binding]; other site 1129794006679 putative substrate binding site 1 [chemical binding]; other site 1129794006680 Na binding site 1 [ion binding]; other site 1129794006681 putative substrate binding site 2 [chemical binding]; other site 1129794006682 carboxy-terminal protease; Provisional; Region: PRK11186 1129794006683 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1129794006684 protein binding site [polypeptide binding]; other site 1129794006685 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1129794006686 Catalytic dyad [active] 1129794006687 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1129794006688 ProP expression regulator; Provisional; Region: PRK04950 1129794006689 ProQ/FINO family; Region: ProQ; smart00945 1129794006690 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1129794006691 GAF domain; Region: GAF_2; pfam13185 1129794006692 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1129794006693 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1129794006694 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1129794006695 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794006696 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1129794006697 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1129794006698 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1129794006699 substrate binding site [chemical binding]; other site 1129794006700 ligand binding site [chemical binding]; other site 1129794006701 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1129794006702 substrate binding site [chemical binding]; other site 1129794006703 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1129794006704 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1129794006705 dimer interface [polypeptide binding]; other site 1129794006706 active site 1129794006707 citrylCoA binding site [chemical binding]; other site 1129794006708 oxalacetate/citrate binding site [chemical binding]; other site 1129794006709 coenzyme A binding site [chemical binding]; other site 1129794006710 catalytic triad [active] 1129794006711 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1129794006712 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1129794006713 tetramer interface [polypeptide binding]; other site 1129794006714 active site 1129794006715 Mg2+/Mn2+ binding site [ion binding]; other site 1129794006716 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1129794006717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794006718 DNA-binding site [nucleotide binding]; DNA binding site 1129794006719 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1129794006720 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1129794006721 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794006722 catalytic residue [active] 1129794006723 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1129794006724 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1129794006725 trimer interface [polypeptide binding]; other site 1129794006726 putative metal binding site [ion binding]; other site 1129794006727 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1129794006728 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1129794006729 active site 1129794006730 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1129794006731 catalytic triad [active] 1129794006732 dimer interface [polypeptide binding]; other site 1129794006733 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1129794006734 active site 1129794006735 ATP binding site [chemical binding]; other site 1129794006736 substrate binding site [chemical binding]; other site 1129794006737 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1129794006738 substrate binding site [chemical binding]; other site 1129794006739 activation loop (A-loop); other site 1129794006740 activation loop (A-loop); other site 1129794006741 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1129794006742 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1129794006743 2-oxoisovalerate dehydrogenase E2 component; Region: PLN02528 1129794006744 E3 interaction surface; other site 1129794006745 lipoyl attachment site [posttranslational modification]; other site 1129794006746 e3 binding domain; Region: E3_binding; pfam02817 1129794006747 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1129794006748 3-methyl-2-oxobutanate dehydrogenase; Provisional; Region: PTZ00182 1129794006749 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1129794006750 alpha subunit interface [polypeptide binding]; other site 1129794006751 TPP binding site [chemical binding]; other site 1129794006752 heterodimer interface [polypeptide binding]; other site 1129794006753 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1129794006754 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1129794006755 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1129794006756 tetramer interface [polypeptide binding]; other site 1129794006757 TPP-binding site [chemical binding]; other site 1129794006758 heterodimer interface [polypeptide binding]; other site 1129794006759 phosphorylation loop region [posttranslational modification] 1129794006760 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794006761 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794006762 N-terminal plug; other site 1129794006763 ligand-binding site [chemical binding]; other site 1129794006764 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1129794006765 FecR protein; Region: FecR; pfam04773 1129794006766 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1129794006767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794006768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794006769 DNA binding residues [nucleotide binding] 1129794006770 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1129794006771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794006772 binding surface 1129794006773 TPR motif; other site 1129794006774 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1129794006775 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794006776 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794006777 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1129794006778 putative inner membrane peptidase; Provisional; Region: PRK11778 1129794006779 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1129794006780 tandem repeat interface [polypeptide binding]; other site 1129794006781 oligomer interface [polypeptide binding]; other site 1129794006782 active site residues [active] 1129794006783 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 1129794006784 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1129794006785 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 1129794006786 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1129794006787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794006788 NAD(P) binding site [chemical binding]; other site 1129794006789 active site 1129794006790 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1129794006791 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1129794006792 active site 1129794006793 HIGH motif; other site 1129794006794 nucleotide binding site [chemical binding]; other site 1129794006795 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1129794006796 KMSKS motif; other site 1129794006797 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1129794006798 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1129794006799 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1129794006800 DNA binding site [nucleotide binding] 1129794006801 domain linker motif; other site 1129794006802 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1129794006803 putative dimerization interface [polypeptide binding]; other site 1129794006804 putative ligand binding site [chemical binding]; other site 1129794006805 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1129794006806 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1129794006807 active site 1129794006808 catalytic site [active] 1129794006809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794006810 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1129794006811 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1129794006812 Rhomboid family; Region: Rhomboid; cl11446 1129794006813 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794006814 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794006815 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794006816 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1129794006817 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1129794006818 Ligand binding site; other site 1129794006819 metal-binding site 1129794006820 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1129794006821 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1129794006822 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1129794006823 RDD family; Region: RDD; pfam06271 1129794006824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1129794006825 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1129794006826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794006827 Walker A motif; other site 1129794006828 ATP binding site [chemical binding]; other site 1129794006829 Walker B motif; other site 1129794006830 arginine finger; other site 1129794006831 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1129794006832 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1129794006833 dimer interface [polypeptide binding]; other site 1129794006834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794006835 catalytic residue [active] 1129794006836 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1129794006837 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1129794006838 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 1129794006839 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1129794006840 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794006841 short chain dehydrogenase; Provisional; Region: PRK07035 1129794006842 classical (c) SDRs; Region: SDR_c; cd05233 1129794006843 NAD(P) binding site [chemical binding]; other site 1129794006844 active site 1129794006845 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1129794006846 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1129794006847 NAD(P) binding site [chemical binding]; other site 1129794006848 substrate binding site [chemical binding]; other site 1129794006849 dimer interface [polypeptide binding]; other site 1129794006850 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1129794006851 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1129794006852 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794006853 active site 1129794006854 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1129794006855 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1129794006856 conserved cys residue [active] 1129794006857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794006858 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 1129794006859 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1129794006860 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1129794006861 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1129794006862 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1129794006863 Ligand binding site [chemical binding]; other site 1129794006864 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1129794006865 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1129794006866 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1129794006867 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1129794006868 acyl-CoA esterase; Provisional; Region: PRK10673 1129794006869 PGAP1-like protein; Region: PGAP1; pfam07819 1129794006870 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1129794006871 flavodoxin FldA; Validated; Region: PRK09267 1129794006872 ferric uptake regulator; Provisional; Region: fur; PRK09462 1129794006873 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1129794006874 metal binding site 2 [ion binding]; metal-binding site 1129794006875 putative DNA binding helix; other site 1129794006876 metal binding site 1 [ion binding]; metal-binding site 1129794006877 dimer interface [polypeptide binding]; other site 1129794006878 structural Zn2+ binding site [ion binding]; other site 1129794006879 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1129794006880 putative FMN binding site [chemical binding]; other site 1129794006881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794006882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794006883 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794006884 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1129794006885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794006886 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1129794006887 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794006888 active site 1129794006889 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1129794006890 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1129794006891 FMN binding site [chemical binding]; other site 1129794006892 substrate binding site [chemical binding]; other site 1129794006893 putative catalytic residue [active] 1129794006894 enoyl-CoA hydratase; Provisional; Region: PRK08260 1129794006895 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794006896 substrate binding site [chemical binding]; other site 1129794006897 oxyanion hole (OAH) forming residues; other site 1129794006898 trimer interface [polypeptide binding]; other site 1129794006899 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1129794006900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794006901 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1129794006902 active site 1129794006903 motif I; other site 1129794006904 motif II; other site 1129794006905 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1129794006906 MoaE homodimer interface [polypeptide binding]; other site 1129794006907 MoaD interaction [polypeptide binding]; other site 1129794006908 active site residues [active] 1129794006909 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1129794006910 MoaE interaction surface [polypeptide binding]; other site 1129794006911 MoeB interaction surface [polypeptide binding]; other site 1129794006912 thiocarboxylated glycine; other site 1129794006913 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1129794006914 trimer interface [polypeptide binding]; other site 1129794006915 dimer interface [polypeptide binding]; other site 1129794006916 putative active site [active] 1129794006917 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1129794006918 MPT binding site; other site 1129794006919 trimer interface [polypeptide binding]; other site 1129794006920 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1129794006921 GTP binding site; other site 1129794006922 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1129794006923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794006924 FeS/SAM binding site; other site 1129794006925 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1129794006926 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1129794006927 active site 1129794006928 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 1129794006929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794006930 active site 1129794006931 motif I; other site 1129794006932 motif II; other site 1129794006933 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794006934 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1129794006935 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1129794006936 trehalose synthase; Region: treS_nterm; TIGR02456 1129794006937 active site 1129794006938 homodimer interface [polypeptide binding]; other site 1129794006939 catalytic site [active] 1129794006940 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1129794006941 EF-hand domain pair; Region: EF_hand_5; pfam13499 1129794006942 pseudo EF-hand loop; other site 1129794006943 peptide binding pocket; other site 1129794006944 Ca2+ binding site [ion binding]; other site 1129794006945 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1129794006946 pseudo EF-hand loop; other site 1129794006947 peptide binding pocket; other site 1129794006948 Ca2+ binding site [ion binding]; other site 1129794006949 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1129794006950 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1129794006951 active site residue [active] 1129794006952 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1129794006953 active site residue [active] 1129794006954 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1129794006955 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1129794006956 active site 1129794006957 putative substrate binding pocket [chemical binding]; other site 1129794006958 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794006959 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1129794006960 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794006961 Purine nucleoside permease (NUP); Region: NUP; pfam06516 1129794006962 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1129794006963 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1129794006964 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1129794006965 active site 1129794006966 purine riboside binding site [chemical binding]; other site 1129794006967 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1129794006968 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1129794006969 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1129794006970 putative active site [active] 1129794006971 putative catalytic site [active] 1129794006972 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1129794006973 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794006974 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1129794006975 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1129794006976 active site 1129794006977 catalytic site [active] 1129794006978 tetramer interface [polypeptide binding]; other site 1129794006979 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1129794006980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794006981 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1129794006982 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1129794006983 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794006984 catalytic loop [active] 1129794006985 iron binding site [ion binding]; other site 1129794006986 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1129794006987 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1129794006988 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1129794006989 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1129794006990 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794006991 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1129794006992 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1129794006993 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1129794006994 putative OHCU decarboxylase; Provisional; Region: PRK13798 1129794006995 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1129794006996 active site 1129794006997 homotetramer interface [polypeptide binding]; other site 1129794006998 guanine deaminase; Provisional; Region: PRK09228 1129794006999 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1129794007000 active site 1129794007001 Predicted membrane protein [Function unknown]; Region: COG3748 1129794007002 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1129794007003 Cytochrome c; Region: Cytochrom_C; pfam00034 1129794007004 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1129794007005 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1129794007006 active site 1129794007007 substrate binding site [chemical binding]; other site 1129794007008 cosubstrate binding site; other site 1129794007009 catalytic site [active] 1129794007010 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1129794007011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794007012 putative substrate translocation pore; other site 1129794007013 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1129794007014 RES domain; Region: RES; smart00953 1129794007015 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1129794007016 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1129794007017 active site 1129794007018 catalytic residues [active] 1129794007019 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1129794007020 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1129794007021 Cytochrome P450; Region: p450; cl12078 1129794007022 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1129794007023 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794007024 catalytic loop [active] 1129794007025 iron binding site [ion binding]; other site 1129794007026 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794007027 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1129794007028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794007029 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1129794007030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794007031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1129794007032 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1129794007033 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1129794007034 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1129794007035 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1129794007036 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1129794007037 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1129794007038 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1129794007039 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 1129794007040 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1129794007041 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1129794007042 nucleotide binding pocket [chemical binding]; other site 1129794007043 K-X-D-G motif; other site 1129794007044 catalytic site [active] 1129794007045 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1129794007046 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1129794007047 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1129794007048 Dimer interface [polypeptide binding]; other site 1129794007049 BRCT sequence motif; other site 1129794007050 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 1129794007051 FtsZ protein binding site [polypeptide binding]; other site 1129794007052 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1129794007053 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1129794007054 Walker A/P-loop; other site 1129794007055 ATP binding site [chemical binding]; other site 1129794007056 Q-loop/lid; other site 1129794007057 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1129794007058 ABC transporter signature motif; other site 1129794007059 Walker B; other site 1129794007060 D-loop; other site 1129794007061 H-loop/switch region; other site 1129794007062 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1129794007063 putative transposase OrfB; Reviewed; Region: PHA02517 1129794007064 HTH-like domain; Region: HTH_21; pfam13276 1129794007065 Integrase core domain; Region: rve; pfam00665 1129794007066 Integrase core domain; Region: rve_3; pfam13683 1129794007067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794007068 Transposase; Region: HTH_Tnp_1; cl17663 1129794007069 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 1129794007070 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1129794007071 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1129794007072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794007073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794007074 metal binding site [ion binding]; metal-binding site 1129794007075 active site 1129794007076 I-site; other site 1129794007077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794007078 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1129794007079 Purine nucleoside permease (NUP); Region: NUP; cl17832 1129794007080 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1129794007081 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1129794007082 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1129794007083 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1129794007084 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794007085 catalytic residue [active] 1129794007086 Fe-S metabolism associated domain; Region: SufE; cl00951 1129794007087 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1129794007088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794007089 Walker A/P-loop; other site 1129794007090 ATP binding site [chemical binding]; other site 1129794007091 Q-loop/lid; other site 1129794007092 ABC transporter signature motif; other site 1129794007093 Walker B; other site 1129794007094 D-loop; other site 1129794007095 H-loop/switch region; other site 1129794007096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794007097 Walker A/P-loop; other site 1129794007098 ATP binding site [chemical binding]; other site 1129794007099 Q-loop/lid; other site 1129794007100 ABC transporter signature motif; other site 1129794007101 Walker B; other site 1129794007102 D-loop; other site 1129794007103 H-loop/switch region; other site 1129794007104 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1129794007105 GAF domain; Region: GAF; pfam01590 1129794007106 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794007107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794007108 metal binding site [ion binding]; metal-binding site 1129794007109 active site 1129794007110 I-site; other site 1129794007111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794007112 H-loop/switch region; other site 1129794007113 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1129794007114 D-cysteine desulfhydrase; Validated; Region: PRK03910 1129794007115 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1129794007116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794007117 catalytic residue [active] 1129794007118 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1129794007119 ligand binding site [chemical binding]; other site 1129794007120 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794007121 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794007122 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1129794007123 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1129794007124 AsnC family; Region: AsnC_trans_reg; pfam01037 1129794007125 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1129794007126 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1129794007127 AsnC family; Region: AsnC_trans_reg; pfam01037 1129794007128 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794007129 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794007130 N-terminal plug; other site 1129794007131 ligand-binding site [chemical binding]; other site 1129794007132 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1129794007133 Na binding site [ion binding]; other site 1129794007134 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1129794007135 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1129794007136 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1129794007137 Protein of unknown function (DUF917); Region: DUF917; pfam06032 1129794007138 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794007139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794007140 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794007141 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794007142 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794007143 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 1129794007144 putative N-terminal domain interface [polypeptide binding]; other site 1129794007145 putative dimer interface [polypeptide binding]; other site 1129794007146 putative substrate binding pocket (H-site) [chemical binding]; other site 1129794007147 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1129794007148 Peptidase family U32; Region: Peptidase_U32; pfam01136 1129794007149 Collagenase; Region: DUF3656; pfam12392 1129794007150 Peptidase family U32; Region: Peptidase_U32; cl03113 1129794007151 High potential iron-sulfur protein; Region: HIPIP; pfam01355 1129794007152 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1129794007153 Catalytic site [active] 1129794007154 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1129794007155 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1129794007156 active site 1129794007157 DNA binding site [nucleotide binding] 1129794007158 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1129794007159 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1129794007160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794007161 Walker A/P-loop; other site 1129794007162 ATP binding site [chemical binding]; other site 1129794007163 Q-loop/lid; other site 1129794007164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794007165 ABC transporter signature motif; other site 1129794007166 Walker B; other site 1129794007167 D-loop; other site 1129794007168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794007169 Walker A/P-loop; other site 1129794007170 ATP binding site [chemical binding]; other site 1129794007171 Q-loop/lid; other site 1129794007172 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794007173 ABC transporter signature motif; other site 1129794007174 Walker B; other site 1129794007175 D-loop; other site 1129794007176 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 1129794007177 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 1129794007178 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1129794007179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1129794007180 active site 1129794007181 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1129794007182 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1129794007183 FtsX-like permease family; Region: FtsX; pfam02687 1129794007184 PilZ domain; Region: PilZ; pfam07238 1129794007185 transcription-repair coupling factor; Provisional; Region: PRK10689 1129794007186 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1129794007187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794007188 ATP binding site [chemical binding]; other site 1129794007189 putative Mg++ binding site [ion binding]; other site 1129794007190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794007191 nucleotide binding region [chemical binding]; other site 1129794007192 ATP-binding site [chemical binding]; other site 1129794007193 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1129794007194 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1129794007195 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1129794007196 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1129794007197 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794007198 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794007199 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794007200 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 1129794007201 homotrimer interaction site [polypeptide binding]; other site 1129794007202 putative active site [active] 1129794007203 Cytochrome c; Region: Cytochrom_C; cl11414 1129794007204 Cytochrome c; Region: Cytochrom_C; cl11414 1129794007205 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1129794007206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1129794007207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794007208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794007209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1129794007210 dimerization interface [polypeptide binding]; other site 1129794007211 Domain of unknown function (DUF1805); Region: DUF1805; pfam08827 1129794007212 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1129794007213 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1129794007214 transmembrane helices; other site 1129794007215 beta-hexosaminidase; Provisional; Region: PRK05337 1129794007216 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1129794007217 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1129794007218 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1129794007219 recombination and repair protein; Provisional; Region: PRK10869 1129794007220 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1129794007221 Walker A/P-loop; other site 1129794007222 ATP binding site [chemical binding]; other site 1129794007223 Q-loop/lid; other site 1129794007224 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1129794007225 ABC transporter signature motif; other site 1129794007226 Walker B; other site 1129794007227 D-loop; other site 1129794007228 H-loop/switch region; other site 1129794007229 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1129794007230 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1129794007231 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1129794007232 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1129794007233 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1129794007234 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794007235 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794007236 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794007237 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1129794007238 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1129794007239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794007240 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1129794007241 dimerization interface [polypeptide binding]; other site 1129794007242 substrate binding pocket [chemical binding]; other site 1129794007243 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1129794007244 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1129794007245 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1129794007246 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1129794007247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794007248 FeS/SAM binding site; other site 1129794007249 TRAM domain; Region: TRAM; pfam01938 1129794007250 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1129794007251 PhoH-like protein; Region: PhoH; pfam02562 1129794007252 metal-binding heat shock protein; Provisional; Region: PRK00016 1129794007253 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1129794007254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1129794007255 Transporter associated domain; Region: CorC_HlyC; smart01091 1129794007256 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1129794007257 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1129794007258 putative active site [active] 1129794007259 catalytic triad [active] 1129794007260 putative dimer interface [polypeptide binding]; other site 1129794007261 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1129794007262 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1129794007263 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794007264 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1129794007265 EamA-like transporter family; Region: EamA; pfam00892 1129794007266 choline dehydrogenase; Validated; Region: PRK02106 1129794007267 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1129794007268 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1129794007269 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1129794007270 acyl-activating enzyme (AAE) consensus motif; other site 1129794007271 putative AMP binding site [chemical binding]; other site 1129794007272 putative active site [active] 1129794007273 putative CoA binding site [chemical binding]; other site 1129794007274 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1129794007275 NAD(P) binding site [chemical binding]; other site 1129794007276 catalytic residues [active] 1129794007277 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794007278 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794007279 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1129794007280 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1129794007281 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1129794007282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1129794007283 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1129794007284 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1129794007285 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1129794007286 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1129794007287 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1129794007288 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1129794007289 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1129794007290 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1129794007291 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1129794007292 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1129794007293 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794007294 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1129794007295 IMP binding site; other site 1129794007296 dimer interface [polypeptide binding]; other site 1129794007297 interdomain contacts; other site 1129794007298 partial ornithine binding site; other site 1129794007299 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1129794007300 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1129794007301 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1129794007302 catalytic site [active] 1129794007303 subunit interface [polypeptide binding]; other site 1129794007304 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1129794007305 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1129794007306 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1129794007307 Bacterial PH domain; Region: DUF304; pfam03703 1129794007308 Predicted membrane protein [Function unknown]; Region: COG3428 1129794007309 Bacterial PH domain; Region: DUF304; pfam03703 1129794007310 Bacterial PH domain; Region: DUF304; pfam03703 1129794007311 chaperone protein DnaJ; Provisional; Region: PRK10767 1129794007312 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1129794007313 HSP70 interaction site [polypeptide binding]; other site 1129794007314 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1129794007315 substrate binding site [polypeptide binding]; other site 1129794007316 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1129794007317 Zn binding sites [ion binding]; other site 1129794007318 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1129794007319 dimer interface [polypeptide binding]; other site 1129794007320 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1129794007321 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1129794007322 nucleotide binding site [chemical binding]; other site 1129794007323 heat shock protein GrpE; Provisional; Region: PRK14140 1129794007324 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1129794007325 dimer interface [polypeptide binding]; other site 1129794007326 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1129794007327 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1129794007328 Na binding site [ion binding]; other site 1129794007329 PAS domain; Region: PAS; smart00091 1129794007330 PAS fold; Region: PAS_7; pfam12860 1129794007331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794007332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794007333 dimer interface [polypeptide binding]; other site 1129794007334 phosphorylation site [posttranslational modification] 1129794007335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794007336 ATP binding site [chemical binding]; other site 1129794007337 Mg2+ binding site [ion binding]; other site 1129794007338 G-X-G motif; other site 1129794007339 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794007340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007341 active site 1129794007342 phosphorylation site [posttranslational modification] 1129794007343 intermolecular recognition site; other site 1129794007344 dimerization interface [polypeptide binding]; other site 1129794007345 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 1129794007346 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1129794007347 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1129794007348 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1129794007349 dimer interface [polypeptide binding]; other site 1129794007350 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1129794007351 active site 1129794007352 Fe binding site [ion binding]; other site 1129794007353 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1129794007354 Proline dehydrogenase; Region: Pro_dh; pfam01619 1129794007355 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1129794007356 Glutamate binding site [chemical binding]; other site 1129794007357 NAD binding site [chemical binding]; other site 1129794007358 catalytic residues [active] 1129794007359 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1129794007360 NAD(P) binding site [chemical binding]; other site 1129794007361 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1129794007362 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1129794007363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794007364 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1129794007365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007366 active site 1129794007367 phosphorylation site [posttranslational modification] 1129794007368 intermolecular recognition site; other site 1129794007369 dimerization interface [polypeptide binding]; other site 1129794007370 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794007371 DNA binding residues [nucleotide binding] 1129794007372 dimerization interface [polypeptide binding]; other site 1129794007373 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794007374 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794007375 N-terminal plug; other site 1129794007376 ligand-binding site [chemical binding]; other site 1129794007377 Citrate transporter; Region: CitMHS; pfam03600 1129794007378 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1129794007379 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1129794007380 homoserine O-acetyltransferase; Provisional; Region: PRK06765 1129794007381 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1129794007382 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1129794007383 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1129794007384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794007385 NAD(P) binding site [chemical binding]; other site 1129794007386 active site 1129794007387 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1129794007388 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794007389 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794007390 metal binding site [ion binding]; metal-binding site 1129794007391 active site 1129794007392 I-site; other site 1129794007393 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794007394 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1129794007395 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1129794007396 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1129794007397 RNA binding surface [nucleotide binding]; other site 1129794007398 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794007399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1129794007400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1129794007401 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1129794007402 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1129794007403 NADP binding site [chemical binding]; other site 1129794007404 homodimer interface [polypeptide binding]; other site 1129794007405 active site 1129794007406 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1129794007407 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1129794007408 Ligand binding site; other site 1129794007409 oligomer interface; other site 1129794007410 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1129794007411 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 1129794007412 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1129794007413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794007414 Q-loop/lid; other site 1129794007415 ABC transporter signature motif; other site 1129794007416 Walker B; other site 1129794007417 D-loop; other site 1129794007418 H-loop/switch region; other site 1129794007419 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1129794007420 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1129794007421 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1129794007422 Competence protein; Region: Competence; pfam03772 1129794007423 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1129794007424 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1129794007425 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1129794007426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794007427 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794007428 I-site; other site 1129794007429 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1129794007430 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1129794007431 HPr interaction site; other site 1129794007432 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1129794007433 active site 1129794007434 phosphorylation site [posttranslational modification] 1129794007435 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794007436 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794007437 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1129794007438 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1129794007439 metal binding site [ion binding]; metal-binding site 1129794007440 dimer interface [polypeptide binding]; other site 1129794007441 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1129794007442 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1129794007443 active site 1129794007444 cosubstrate binding site; other site 1129794007445 substrate binding site [chemical binding]; other site 1129794007446 catalytic site [active] 1129794007447 hypothetical protein; Provisional; Region: PRK02877 1129794007448 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1129794007449 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1129794007450 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1129794007451 putative active site [active] 1129794007452 Zn binding site [ion binding]; other site 1129794007453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794007454 metal binding site [ion binding]; metal-binding site 1129794007455 active site 1129794007456 I-site; other site 1129794007457 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794007458 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1129794007459 homodimer interface [polypeptide binding]; other site 1129794007460 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1129794007461 active site pocket [active] 1129794007462 phosphoglucomutase; Validated; Region: PRK07564 1129794007463 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1129794007464 active site 1129794007465 substrate binding site [chemical binding]; other site 1129794007466 metal binding site [ion binding]; metal-binding site 1129794007467 SeqA protein; Region: SeqA; pfam03925 1129794007468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794007469 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1129794007470 Walker A motif; other site 1129794007471 ATP binding site [chemical binding]; other site 1129794007472 Walker B motif; other site 1129794007473 arginine finger; other site 1129794007474 Protein of unknown function DUF58; Region: DUF58; pfam01882 1129794007475 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1129794007476 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1129794007477 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1129794007478 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1129794007479 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794007480 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794007481 ABC transporter; Region: ABC_tran_2; pfam12848 1129794007482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794007483 Outer membrane efflux protein; Region: OEP; pfam02321 1129794007484 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1129794007485 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794007486 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1129794007487 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1129794007488 LabA_like proteins; Region: LabA_like/DUF88; cl10034 1129794007489 putative metal binding site [ion binding]; other site 1129794007490 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1129794007491 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1129794007492 G1 box; other site 1129794007493 GTP/Mg2+ binding site [chemical binding]; other site 1129794007494 Switch I region; other site 1129794007495 G2 box; other site 1129794007496 G3 box; other site 1129794007497 Switch II region; other site 1129794007498 G4 box; other site 1129794007499 G5 box; other site 1129794007500 Nucleoside recognition; Region: Gate; pfam07670 1129794007501 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1129794007502 Nucleoside recognition; Region: Gate; pfam07670 1129794007503 FeoA domain; Region: FeoA; pfam04023 1129794007504 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1129794007505 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1129794007506 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1129794007507 active site 1129794007508 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1129794007509 active site pocket [active] 1129794007510 oxyanion hole [active] 1129794007511 catalytic triad [active] 1129794007512 active site nucleophile [active] 1129794007513 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1129794007514 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794007515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007516 active site 1129794007517 phosphorylation site [posttranslational modification] 1129794007518 intermolecular recognition site; other site 1129794007519 dimerization interface [polypeptide binding]; other site 1129794007520 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 1129794007521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 1129794007522 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 1129794007523 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794007524 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1129794007525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794007526 catalytic residue [active] 1129794007527 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1129794007528 Endonuclease I; Region: Endonuclease_1; pfam04231 1129794007529 AAA domain; Region: AAA_26; pfam13500 1129794007530 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1129794007531 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1129794007532 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1129794007533 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794007534 catalytic residue [active] 1129794007535 biotin synthase; Provisional; Region: PRK15108 1129794007536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794007537 FeS/SAM binding site; other site 1129794007538 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1129794007539 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1129794007540 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1129794007541 inhibitor-cofactor binding pocket; inhibition site 1129794007542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794007543 catalytic residue [active] 1129794007544 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1129794007545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1129794007546 binding surface 1129794007547 TPR motif; other site 1129794007548 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 1129794007549 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794007550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007551 active site 1129794007552 phosphorylation site [posttranslational modification] 1129794007553 intermolecular recognition site; other site 1129794007554 dimerization interface [polypeptide binding]; other site 1129794007555 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1129794007556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794007557 Zn2+ binding site [ion binding]; other site 1129794007558 Mg2+ binding site [ion binding]; other site 1129794007559 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1129794007560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794007561 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1129794007562 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1129794007563 RF-1 domain; Region: RF-1; pfam00472 1129794007564 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1129794007565 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1129794007566 tRNA; other site 1129794007567 putative tRNA binding site [nucleotide binding]; other site 1129794007568 putative NADP binding site [chemical binding]; other site 1129794007569 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1129794007570 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1129794007571 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1129794007572 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1129794007573 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1129794007574 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1129794007575 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1129794007576 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1129794007577 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1129794007578 active site 1129794007579 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1129794007580 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1129794007581 5S rRNA interface [nucleotide binding]; other site 1129794007582 CTC domain interface [polypeptide binding]; other site 1129794007583 L16 interface [polypeptide binding]; other site 1129794007584 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1129794007585 putative active site [active] 1129794007586 catalytic residue [active] 1129794007587 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1129794007588 G1 box; other site 1129794007589 GTP/Mg2+ binding site [chemical binding]; other site 1129794007590 G2 box; other site 1129794007591 Switch I region; other site 1129794007592 G3 box; other site 1129794007593 Switch II region; other site 1129794007594 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1129794007595 G4 box; other site 1129794007596 G5 box; other site 1129794007597 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1129794007598 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1129794007599 amino acid carrier protein; Region: agcS; TIGR00835 1129794007600 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1129794007601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794007602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794007603 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1129794007604 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1129794007605 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1129794007606 GTP/Mg2+ binding site [chemical binding]; other site 1129794007607 G4 box; other site 1129794007608 G5 box; other site 1129794007609 G1 box; other site 1129794007610 Switch I region; other site 1129794007611 G2 box; other site 1129794007612 G3 box; other site 1129794007613 Switch II region; other site 1129794007614 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 1129794007615 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1129794007616 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1129794007617 active site 1129794007618 ADP/pyrophosphate binding site [chemical binding]; other site 1129794007619 allosteric effector site; other site 1129794007620 dimerization interface [polypeptide binding]; other site 1129794007621 fructose-1,6-bisphosphate binding site; other site 1129794007622 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1129794007623 two-component response regulator; Provisional; Region: PRK14084 1129794007624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007625 active site 1129794007626 phosphorylation site [posttranslational modification] 1129794007627 intermolecular recognition site; other site 1129794007628 dimerization interface [polypeptide binding]; other site 1129794007629 LytTr DNA-binding domain; Region: LytTR; smart00850 1129794007630 Histidine kinase; Region: His_kinase; pfam06580 1129794007631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794007632 ATP binding site [chemical binding]; other site 1129794007633 Mg2+ binding site [ion binding]; other site 1129794007634 G-X-G motif; other site 1129794007635 Protein of unknown function (DUF962); Region: DUF962; cl01879 1129794007636 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1129794007637 PilZ domain; Region: PilZ; pfam07238 1129794007638 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1129794007639 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1129794007640 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1129794007641 Zn binding site [ion binding]; other site 1129794007642 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1129794007643 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794007644 RmuC family; Region: RmuC; pfam02646 1129794007645 RmuC family; Region: RmuC; pfam02646 1129794007646 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1129794007647 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1129794007648 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1129794007649 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1129794007650 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1129794007651 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1129794007652 putative active site [active] 1129794007653 putative CoA binding site [chemical binding]; other site 1129794007654 nudix motif; other site 1129794007655 metal binding site [ion binding]; metal-binding site 1129794007656 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1129794007657 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1129794007658 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1129794007659 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1129794007660 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794007661 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1129794007662 substrate binding site [chemical binding]; other site 1129794007663 dimerization interface [polypeptide binding]; other site 1129794007664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794007665 ATP binding site [chemical binding]; other site 1129794007666 Mg2+ binding site [ion binding]; other site 1129794007667 G-X-G motif; other site 1129794007668 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794007669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794007670 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1129794007671 putative dimerization interface [polypeptide binding]; other site 1129794007672 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1129794007673 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1129794007674 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1129794007675 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794007676 ATP binding site [chemical binding]; other site 1129794007677 Mg++ binding site [ion binding]; other site 1129794007678 motif III; other site 1129794007679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794007680 nucleotide binding region [chemical binding]; other site 1129794007681 ATP-binding site [chemical binding]; other site 1129794007682 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794007683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794007684 metal binding site [ion binding]; metal-binding site 1129794007685 active site 1129794007686 I-site; other site 1129794007687 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1129794007688 putative FMN binding site [chemical binding]; other site 1129794007689 DoxX; Region: DoxX; pfam07681 1129794007690 Predicted integral membrane protein [Function unknown]; Region: COG5616 1129794007691 Predicted integral membrane protein [Function unknown]; Region: COG5616 1129794007692 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794007693 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794007694 Fic/DOC family; Region: Fic; cl00960 1129794007695 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1129794007696 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1129794007697 active site 1129794007698 dinuclear metal binding site [ion binding]; other site 1129794007699 dimerization interface [polypeptide binding]; other site 1129794007700 Predicted transcriptional regulator [Transcription]; Region: COG2944 1129794007701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794007702 salt bridge; other site 1129794007703 non-specific DNA binding site [nucleotide binding]; other site 1129794007704 sequence-specific DNA binding site [nucleotide binding]; other site 1129794007705 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1129794007706 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1129794007707 putative active site [active] 1129794007708 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1129794007709 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 1129794007710 translocation protein TolB; Provisional; Region: tolB; PRK00178 1129794007711 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794007712 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1129794007713 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1129794007714 active site 1129794007715 dimer interface [polypeptide binding]; other site 1129794007716 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1129794007717 Ligand Binding Site [chemical binding]; other site 1129794007718 Molecular Tunnel; other site 1129794007719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1129794007720 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1129794007721 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1129794007722 active site 1129794007723 metal binding site [ion binding]; metal-binding site 1129794007724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794007725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794007726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1129794007727 dimerization interface [polypeptide binding]; other site 1129794007728 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 1129794007729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794007730 S-adenosylmethionine binding site [chemical binding]; other site 1129794007731 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1129794007732 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1129794007733 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1129794007734 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1129794007735 active site 1129794007736 tetramer interface [polypeptide binding]; other site 1129794007737 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1129794007738 active site 1129794007739 Colicin V production protein; Region: Colicin_V; cl00567 1129794007740 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1129794007741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1129794007742 Sporulation related domain; Region: SPOR; pfam05036 1129794007743 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1129794007744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1129794007745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1129794007746 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1129794007747 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1129794007748 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1129794007749 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1129794007750 dimerization interface 3.5A [polypeptide binding]; other site 1129794007751 active site 1129794007752 response regulator GlrR; Provisional; Region: PRK15115 1129794007753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007754 active site 1129794007755 phosphorylation site [posttranslational modification] 1129794007756 intermolecular recognition site; other site 1129794007757 dimerization interface [polypeptide binding]; other site 1129794007758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794007759 Walker A motif; other site 1129794007760 ATP binding site [chemical binding]; other site 1129794007761 Walker B motif; other site 1129794007762 arginine finger; other site 1129794007763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794007764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794007765 dimer interface [polypeptide binding]; other site 1129794007766 phosphorylation site [posttranslational modification] 1129794007767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794007768 ATP binding site [chemical binding]; other site 1129794007769 Mg2+ binding site [ion binding]; other site 1129794007770 G-X-G motif; other site 1129794007771 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1129794007772 EF-hand domain pair; Region: EF_hand_5; pfam13499 1129794007773 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1129794007774 putative metal binding site [ion binding]; other site 1129794007775 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1129794007776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1129794007777 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1129794007778 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1129794007779 Walker A/P-loop; other site 1129794007780 ATP binding site [chemical binding]; other site 1129794007781 Q-loop/lid; other site 1129794007782 ABC transporter signature motif; other site 1129794007783 Walker B; other site 1129794007784 D-loop; other site 1129794007785 H-loop/switch region; other site 1129794007786 TOBE domain; Region: TOBE_2; pfam08402 1129794007787 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1129794007788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794007789 dimer interface [polypeptide binding]; other site 1129794007790 conserved gate region; other site 1129794007791 putative PBP binding loops; other site 1129794007792 ABC-ATPase subunit interface; other site 1129794007793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794007794 dimer interface [polypeptide binding]; other site 1129794007795 conserved gate region; other site 1129794007796 putative PBP binding loops; other site 1129794007797 ABC-ATPase subunit interface; other site 1129794007798 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1129794007799 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1129794007800 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794007801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794007802 Coenzyme A binding pocket [chemical binding]; other site 1129794007803 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1129794007804 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794007805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007806 active site 1129794007807 phosphorylation site [posttranslational modification] 1129794007808 intermolecular recognition site; other site 1129794007809 dimerization interface [polypeptide binding]; other site 1129794007810 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1129794007811 anti sigma factor interaction site; other site 1129794007812 regulatory phosphorylation site [posttranslational modification]; other site 1129794007813 translation initiation factor Sui1; Validated; Region: PRK06824 1129794007814 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1129794007815 putative rRNA binding site [nucleotide binding]; other site 1129794007816 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1129794007817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007818 active site 1129794007819 phosphorylation site [posttranslational modification] 1129794007820 intermolecular recognition site; other site 1129794007821 dimerization interface [polypeptide binding]; other site 1129794007822 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1129794007823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007824 active site 1129794007825 phosphorylation site [posttranslational modification] 1129794007826 intermolecular recognition site; other site 1129794007827 dimerization interface [polypeptide binding]; other site 1129794007828 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1129794007829 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1129794007830 Prephenate dehydratase; Region: PDT; pfam00800 1129794007831 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1129794007832 putative L-Phe binding site [chemical binding]; other site 1129794007833 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1129794007834 16S/18S rRNA binding site [nucleotide binding]; other site 1129794007835 S13e-L30e interaction site [polypeptide binding]; other site 1129794007836 25S rRNA binding site [nucleotide binding]; other site 1129794007837 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1129794007838 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1129794007839 RNA binding site [nucleotide binding]; other site 1129794007840 active site 1129794007841 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1129794007842 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1129794007843 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1129794007844 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1129794007845 translation initiation factor IF-2; Region: IF-2; TIGR00487 1129794007846 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1129794007847 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1129794007848 G1 box; other site 1129794007849 putative GEF interaction site [polypeptide binding]; other site 1129794007850 GTP/Mg2+ binding site [chemical binding]; other site 1129794007851 Switch I region; other site 1129794007852 G2 box; other site 1129794007853 G3 box; other site 1129794007854 Switch II region; other site 1129794007855 G4 box; other site 1129794007856 G5 box; other site 1129794007857 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1129794007858 Translation-initiation factor 2; Region: IF-2; pfam11987 1129794007859 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1129794007860 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1129794007861 NusA N-terminal domain; Region: NusA_N; pfam08529 1129794007862 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1129794007863 RNA binding site [nucleotide binding]; other site 1129794007864 homodimer interface [polypeptide binding]; other site 1129794007865 NusA-like KH domain; Region: KH_5; pfam13184 1129794007866 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1129794007867 G-X-X-G motif; other site 1129794007868 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1129794007869 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1129794007870 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1129794007871 hypothetical protein; Provisional; Region: PRK14641 1129794007872 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1129794007873 putative oligomer interface [polypeptide binding]; other site 1129794007874 putative RNA binding site [nucleotide binding]; other site 1129794007875 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1129794007876 aromatic arch; other site 1129794007877 DCoH dimer interaction site [polypeptide binding]; other site 1129794007878 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1129794007879 DCoH tetramer interaction site [polypeptide binding]; other site 1129794007880 substrate binding site [chemical binding]; other site 1129794007881 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794007882 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794007883 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794007884 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1129794007885 active site 2 [active] 1129794007886 active site 1 [active] 1129794007887 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1129794007888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794007889 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1129794007890 substrate binding pocket [chemical binding]; other site 1129794007891 dimerization interface [polypeptide binding]; other site 1129794007892 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1129794007893 metal binding site [ion binding]; metal-binding site 1129794007894 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1129794007895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794007896 Walker A/P-loop; other site 1129794007897 ATP binding site [chemical binding]; other site 1129794007898 Q-loop/lid; other site 1129794007899 ABC transporter signature motif; other site 1129794007900 Walker B; other site 1129794007901 D-loop; other site 1129794007902 H-loop/switch region; other site 1129794007903 TOBE domain; Region: TOBE; pfam03459 1129794007904 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1129794007905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794007906 putative PBP binding loops; other site 1129794007907 dimer interface [polypeptide binding]; other site 1129794007908 ABC-ATPase subunit interface; other site 1129794007909 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1129794007910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1129794007911 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1129794007912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1129794007913 DNA binding residues [nucleotide binding] 1129794007914 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1129794007915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794007916 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1129794007917 active site residue [active] 1129794007918 CreA protein; Region: CreA; pfam05981 1129794007919 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1129794007920 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794007921 ATP binding site [chemical binding]; other site 1129794007922 Mg++ binding site [ion binding]; other site 1129794007923 motif III; other site 1129794007924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794007925 nucleotide binding region [chemical binding]; other site 1129794007926 ATP-binding site [chemical binding]; other site 1129794007927 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1129794007928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794007929 active site 1129794007930 phosphorylation site [posttranslational modification] 1129794007931 intermolecular recognition site; other site 1129794007932 dimerization interface [polypeptide binding]; other site 1129794007933 LytTr DNA-binding domain; Region: LytTR; smart00850 1129794007934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794007935 Histidine kinase; Region: His_kinase; pfam06580 1129794007936 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1129794007937 ATP binding site [chemical binding]; other site 1129794007938 Mg2+ binding site [ion binding]; other site 1129794007939 G-X-G motif; other site 1129794007940 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1129794007941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794007942 putative substrate translocation pore; other site 1129794007943 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1129794007944 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1129794007945 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1129794007946 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794007947 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794007948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1129794007949 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1129794007950 SapC; Region: SapC; pfam07277 1129794007951 Cupin-like domain; Region: Cupin_8; pfam13621 1129794007952 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1129794007953 MFS/sugar transport protein; Region: MFS_2; pfam13347 1129794007954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794007955 putative substrate translocation pore; other site 1129794007956 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1129794007957 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1129794007958 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1129794007959 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1129794007960 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1129794007961 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1129794007962 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1129794007963 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1129794007964 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1129794007965 hypothetical protein; Validated; Region: PRK00029 1129794007966 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1129794007967 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1129794007968 acyl-activating enzyme (AAE) consensus motif; other site 1129794007969 putative AMP binding site [chemical binding]; other site 1129794007970 putative active site [active] 1129794007971 putative CoA binding site [chemical binding]; other site 1129794007972 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1129794007973 EamA-like transporter family; Region: EamA; pfam00892 1129794007974 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1129794007975 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1129794007976 active site 1129794007977 catalytic site [active] 1129794007978 substrate binding site [chemical binding]; other site 1129794007979 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1129794007980 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1129794007981 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1129794007982 metal binding triad; other site 1129794007983 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1129794007984 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1129794007985 Na binding site [ion binding]; other site 1129794007986 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1129794007987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1129794007988 dimer interface [polypeptide binding]; other site 1129794007989 active site 1129794007990 metal binding site [ion binding]; metal-binding site 1129794007991 glutathione binding site [chemical binding]; other site 1129794007992 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794007993 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1129794007994 UbiA prenyltransferase family; Region: UbiA; pfam01040 1129794007995 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1129794007996 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1129794007997 Subunit I/III interface [polypeptide binding]; other site 1129794007998 Subunit III/IV interface [polypeptide binding]; other site 1129794007999 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1129794008000 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1129794008001 D-pathway; other site 1129794008002 Putative ubiquinol binding site [chemical binding]; other site 1129794008003 Low-spin heme (heme b) binding site [chemical binding]; other site 1129794008004 Putative water exit pathway; other site 1129794008005 Binuclear center (heme o3/CuB) [ion binding]; other site 1129794008006 K-pathway; other site 1129794008007 Putative proton exit pathway; other site 1129794008008 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1129794008009 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1129794008010 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1129794008011 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1129794008012 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1129794008013 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1129794008014 Na binding site [ion binding]; other site 1129794008015 PAS fold; Region: PAS_7; pfam12860 1129794008016 PAS domain; Region: PAS; smart00091 1129794008017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794008018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794008019 dimer interface [polypeptide binding]; other site 1129794008020 phosphorylation site [posttranslational modification] 1129794008021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794008022 ATP binding site [chemical binding]; other site 1129794008023 Mg2+ binding site [ion binding]; other site 1129794008024 G-X-G motif; other site 1129794008025 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794008026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008027 active site 1129794008028 phosphorylation site [posttranslational modification] 1129794008029 intermolecular recognition site; other site 1129794008030 dimerization interface [polypeptide binding]; other site 1129794008031 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1129794008032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008033 active site 1129794008034 phosphorylation site [posttranslational modification] 1129794008035 intermolecular recognition site; other site 1129794008036 dimerization interface [polypeptide binding]; other site 1129794008037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794008038 DNA binding residues [nucleotide binding] 1129794008039 dimerization interface [polypeptide binding]; other site 1129794008040 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1129794008041 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1129794008042 active site 1129794008043 CoA binding site [chemical binding]; other site 1129794008044 acyl-activating enzyme (AAE) consensus motif; other site 1129794008045 AMP binding site [chemical binding]; other site 1129794008046 acetate binding site [chemical binding]; other site 1129794008047 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1129794008048 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1129794008049 CoenzymeA binding site [chemical binding]; other site 1129794008050 subunit interaction site [polypeptide binding]; other site 1129794008051 PHB binding site; other site 1129794008052 PAS domain; Region: PAS_9; pfam13426 1129794008053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794008054 putative active site [active] 1129794008055 heme pocket [chemical binding]; other site 1129794008056 PAS domain; Region: PAS_9; pfam13426 1129794008057 PAS domain; Region: PAS_9; pfam13426 1129794008058 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794008059 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794008060 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1129794008061 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1129794008062 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1129794008063 transcriptional activator RfaH; Region: RfaH; TIGR01955 1129794008064 tyrosine kinase; Provisional; Region: PRK11519 1129794008065 Chain length determinant protein; Region: Wzz; pfam02706 1129794008066 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1129794008067 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1129794008068 Nucleotide binding site [chemical binding]; other site 1129794008069 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1129794008070 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1129794008071 active site 1129794008072 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1129794008073 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1129794008074 SLBB domain; Region: SLBB; pfam10531 1129794008075 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794008076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1129794008077 DNA binding site [nucleotide binding] 1129794008078 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794008079 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794008080 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794008081 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794008082 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1129794008083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1129794008084 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1129794008085 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1129794008086 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1129794008087 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1129794008088 GAF domain; Region: GAF; pfam01590 1129794008089 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794008090 Poxvirus Late Transcription Factor VLTF3 like; Region: Pox_VLTF3; pfam04947 1129794008091 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794008092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794008093 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794008094 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1129794008095 Peptidase family M50; Region: Peptidase_M50; pfam02163 1129794008096 active site 1129794008097 putative substrate binding region [chemical binding]; other site 1129794008098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794008099 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794008100 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794008101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794008102 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1129794008103 Phosphotransferase enzyme family; Region: APH; pfam01636 1129794008104 putative active site [active] 1129794008105 putative substrate binding site [chemical binding]; other site 1129794008106 ATP binding site [chemical binding]; other site 1129794008107 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1129794008108 triosephosphate isomerase; Provisional; Region: PRK14567 1129794008109 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1129794008110 substrate binding site [chemical binding]; other site 1129794008111 dimer interface [polypeptide binding]; other site 1129794008112 catalytic triad [active] 1129794008113 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1129794008114 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1129794008115 active site 1129794008116 substrate binding site [chemical binding]; other site 1129794008117 metal binding site [ion binding]; metal-binding site 1129794008118 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1129794008119 dihydropteroate synthase; Region: DHPS; TIGR01496 1129794008120 substrate binding pocket [chemical binding]; other site 1129794008121 dimer interface [polypeptide binding]; other site 1129794008122 inhibitor binding site; inhibition site 1129794008123 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1129794008124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794008125 Walker A motif; other site 1129794008126 ATP binding site [chemical binding]; other site 1129794008127 Walker B motif; other site 1129794008128 arginine finger; other site 1129794008129 Peptidase family M41; Region: Peptidase_M41; pfam01434 1129794008130 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1129794008131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794008132 S-adenosylmethionine binding site [chemical binding]; other site 1129794008133 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1129794008134 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1129794008135 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794008136 AAA domain; Region: AAA_32; pfam13654 1129794008137 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1129794008138 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 1129794008139 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1129794008140 HIGH motif; other site 1129794008141 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1129794008142 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1129794008143 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1129794008144 active site 1129794008145 KMSKS motif; other site 1129794008146 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1129794008147 tRNA binding surface [nucleotide binding]; other site 1129794008148 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1129794008149 Lipopolysaccharide-assembly; Region: LptE; cl01125 1129794008150 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1129794008151 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1129794008152 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1129794008153 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1129794008154 active site 1129794008155 (T/H)XGH motif; other site 1129794008156 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1129794008157 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1129794008158 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1129794008159 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1129794008160 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1129794008161 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1129794008162 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1129794008163 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794008164 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1129794008165 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1129794008166 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1129794008167 Sporulation related domain; Region: SPOR; pfam05036 1129794008168 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1129794008169 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1129794008170 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1129794008171 hypothetical protein; Provisional; Region: PRK04998 1129794008172 lipoate-protein ligase B; Provisional; Region: PRK14342 1129794008173 lipoyl synthase; Provisional; Region: PRK05481 1129794008174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794008175 FeS/SAM binding site; other site 1129794008176 phosphomannomutase CpsG; Provisional; Region: PRK15414 1129794008177 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1129794008178 active site 1129794008179 substrate binding site [chemical binding]; other site 1129794008180 metal binding site [ion binding]; metal-binding site 1129794008181 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1129794008182 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1129794008183 Substrate binding site; other site 1129794008184 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1129794008185 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1129794008186 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1129794008187 putative ATP binding site [chemical binding]; other site 1129794008188 putative substrate interface [chemical binding]; other site 1129794008189 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1129794008190 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794008191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794008192 metal binding site [ion binding]; metal-binding site 1129794008193 active site 1129794008194 I-site; other site 1129794008195 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1129794008196 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1129794008197 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1129794008198 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1129794008199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1129794008200 putative DNA binding site [nucleotide binding]; other site 1129794008201 putative Zn2+ binding site [ion binding]; other site 1129794008202 AsnC family; Region: AsnC_trans_reg; pfam01037 1129794008203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794008204 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794008205 acyl-activating enzyme (AAE) consensus motif; other site 1129794008206 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794008207 active site 1129794008208 CoA binding site [chemical binding]; other site 1129794008209 AMP binding site [chemical binding]; other site 1129794008210 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1129794008211 putative substrate binding pocket [chemical binding]; other site 1129794008212 trimer interface [polypeptide binding]; other site 1129794008213 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1129794008214 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1129794008215 putative dimer interface [polypeptide binding]; other site 1129794008216 putative anticodon binding site; other site 1129794008217 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1129794008218 homodimer interface [polypeptide binding]; other site 1129794008219 motif 1; other site 1129794008220 motif 2; other site 1129794008221 active site 1129794008222 motif 3; other site 1129794008223 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1129794008224 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 1129794008225 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1129794008226 NADP binding site [chemical binding]; other site 1129794008227 dimer interface [polypeptide binding]; other site 1129794008228 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1129794008229 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1129794008230 active site 1129794008231 Zn binding site [ion binding]; other site 1129794008232 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1129794008233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794008234 catalytic residue [active] 1129794008235 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1129794008236 Paraquat-inducible protein A; Region: PqiA; pfam04403 1129794008237 Paraquat-inducible protein A; Region: PqiA; pfam04403 1129794008238 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1129794008239 mce related protein; Region: MCE; pfam02470 1129794008240 paraquat-inducible protein B; Provisional; Region: PRK10807 1129794008241 mce related protein; Region: MCE; pfam02470 1129794008242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1129794008243 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1129794008244 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794008245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794008246 metal binding site [ion binding]; metal-binding site 1129794008247 active site 1129794008248 I-site; other site 1129794008249 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1129794008250 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1129794008251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794008252 Walker A/P-loop; other site 1129794008253 ATP binding site [chemical binding]; other site 1129794008254 Q-loop/lid; other site 1129794008255 ABC transporter signature motif; other site 1129794008256 Walker B; other site 1129794008257 D-loop; other site 1129794008258 H-loop/switch region; other site 1129794008259 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1129794008260 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1129794008261 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1129794008262 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1129794008263 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1129794008264 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1129794008265 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1129794008266 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1129794008267 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1129794008268 DNA binding residues [nucleotide binding] 1129794008269 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1129794008270 dimer interface [polypeptide binding]; other site 1129794008271 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1129794008272 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1129794008273 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1129794008274 active site 1129794008275 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1129794008276 homodimer interface [polypeptide binding]; other site 1129794008277 active site 1129794008278 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1129794008279 DNA-binding site [nucleotide binding]; DNA binding site 1129794008280 RNA-binding motif; other site 1129794008281 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1129794008282 MFS_1 like family; Region: MFS_1_like; pfam12832 1129794008283 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1129794008284 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1129794008285 Tetramer interface [polypeptide binding]; other site 1129794008286 active site 1129794008287 FMN-binding site [chemical binding]; other site 1129794008288 HemK family putative methylases; Region: hemK_fam; TIGR00536 1129794008289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794008290 S-adenosylmethionine binding site [chemical binding]; other site 1129794008291 hypothetical protein; Provisional; Region: PRK04946 1129794008292 Smr domain; Region: Smr; pfam01713 1129794008293 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1129794008294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008295 active site 1129794008296 phosphorylation site [posttranslational modification] 1129794008297 intermolecular recognition site; other site 1129794008298 dimerization interface [polypeptide binding]; other site 1129794008299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794008300 Walker A motif; other site 1129794008301 ATP binding site [chemical binding]; other site 1129794008302 Walker B motif; other site 1129794008303 arginine finger; other site 1129794008304 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1129794008305 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1129794008306 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1129794008307 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794008308 active site 1129794008309 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 1129794008310 catalytic site [active] 1129794008311 putative active site [active] 1129794008312 putative substrate binding site [chemical binding]; other site 1129794008313 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1129794008314 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1129794008315 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794008316 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794008317 N-terminal plug; other site 1129794008318 ligand-binding site [chemical binding]; other site 1129794008319 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794008320 hypothetical protein; Provisional; Region: PRK07338 1129794008321 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1129794008322 metal binding site [ion binding]; metal-binding site 1129794008323 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 1129794008324 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1129794008325 active site 1129794008326 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1129794008327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1129794008328 active site 1129794008329 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1129794008330 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1129794008331 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1129794008332 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1129794008333 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1129794008334 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1129794008335 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1129794008336 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794008337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008338 active site 1129794008339 phosphorylation site [posttranslational modification] 1129794008340 intermolecular recognition site; other site 1129794008341 dimerization interface [polypeptide binding]; other site 1129794008342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794008343 dimer interface [polypeptide binding]; other site 1129794008344 phosphorylation site [posttranslational modification] 1129794008345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794008346 ATP binding site [chemical binding]; other site 1129794008347 Mg2+ binding site [ion binding]; other site 1129794008348 G-X-G motif; other site 1129794008349 Heme NO binding; Region: HNOB; pfam07700 1129794008350 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794008351 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1129794008352 catalytic residue [active] 1129794008353 glutamate--cysteine ligase; Provisional; Region: PRK02107 1129794008354 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1129794008355 putative binding surface; other site 1129794008356 active site 1129794008357 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1129794008358 active site 1129794008359 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1129794008360 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1129794008361 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1129794008362 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1129794008363 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1129794008364 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1129794008365 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1129794008366 dimer interface [polypeptide binding]; other site 1129794008367 putative anticodon binding site; other site 1129794008368 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1129794008369 motif 1; other site 1129794008370 active site 1129794008371 motif 2; other site 1129794008372 motif 3; other site 1129794008373 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1129794008374 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1129794008375 RF-1 domain; Region: RF-1; pfam00472 1129794008376 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1129794008377 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794008378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794008379 Predicted deacylase [General function prediction only]; Region: COG3608 1129794008380 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 1129794008381 putative active site [active] 1129794008382 Zn binding site [ion binding]; other site 1129794008383 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 1129794008384 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1129794008385 Predicted flavoprotein [General function prediction only]; Region: COG0431 1129794008386 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1129794008387 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1129794008388 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1129794008389 active site 1129794008390 HIGH motif; other site 1129794008391 KMSK motif region; other site 1129794008392 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1129794008393 tRNA binding surface [nucleotide binding]; other site 1129794008394 anticodon binding site; other site 1129794008395 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1129794008396 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1129794008397 G1 box; other site 1129794008398 putative GEF interaction site [polypeptide binding]; other site 1129794008399 GTP/Mg2+ binding site [chemical binding]; other site 1129794008400 Switch I region; other site 1129794008401 G2 box; other site 1129794008402 G3 box; other site 1129794008403 Switch II region; other site 1129794008404 G4 box; other site 1129794008405 G5 box; other site 1129794008406 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1129794008407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794008408 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1129794008409 non-specific DNA binding site [nucleotide binding]; other site 1129794008410 salt bridge; other site 1129794008411 sequence-specific DNA binding site [nucleotide binding]; other site 1129794008412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794008413 non-specific DNA binding site [nucleotide binding]; other site 1129794008414 salt bridge; other site 1129794008415 sequence-specific DNA binding site [nucleotide binding]; other site 1129794008416 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1129794008417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794008418 Coenzyme A binding pocket [chemical binding]; other site 1129794008419 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1129794008420 Phosphotransferase enzyme family; Region: APH; pfam01636 1129794008421 active site 1129794008422 substrate binding site [chemical binding]; other site 1129794008423 ATP binding site [chemical binding]; other site 1129794008424 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1129794008425 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794008426 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794008427 SdiA-regulated; Region: SdiA-regulated; cd09971 1129794008428 putative active site [active] 1129794008429 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1129794008430 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 1129794008431 Helicase; Region: Helicase_RecD; pfam05127 1129794008432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794008433 Coenzyme A binding pocket [chemical binding]; other site 1129794008434 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1129794008435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794008436 TPR motif; other site 1129794008437 binding surface 1129794008438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794008439 binding surface 1129794008440 TPR motif; other site 1129794008441 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794008442 binding surface 1129794008443 TPR motif; other site 1129794008444 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1129794008445 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1129794008446 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1129794008447 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1129794008448 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 1129794008449 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 1129794008450 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1129794008451 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794008452 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794008453 Late competence development protein ComFB; Region: ComFB; pfam10719 1129794008454 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1129794008455 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1129794008456 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1129794008457 NAD binding site [chemical binding]; other site 1129794008458 Phe binding site; other site 1129794008459 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1129794008460 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1129794008461 AsnC family; Region: AsnC_trans_reg; pfam01037 1129794008462 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1129794008463 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1129794008464 putative aromatic amino acid binding site; other site 1129794008465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794008466 putative active site [active] 1129794008467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794008468 Walker A motif; other site 1129794008469 ATP binding site [chemical binding]; other site 1129794008470 Walker B motif; other site 1129794008471 arginine finger; other site 1129794008472 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1129794008473 cofactor binding site; other site 1129794008474 metal binding site [ion binding]; metal-binding site 1129794008475 hypothetical protein; Provisional; Region: PRK05415 1129794008476 Domain of unknown function (DUF697); Region: DUF697; cl12064 1129794008477 YcjX-like family, DUF463; Region: DUF463; pfam04317 1129794008478 PspC domain; Region: PspC; cl00864 1129794008479 phage shock protein B; Provisional; Region: pspB; PRK09458 1129794008480 phage shock protein PspA; Provisional; Region: PRK10698 1129794008481 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1129794008482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794008483 Walker A motif; other site 1129794008484 ATP binding site [chemical binding]; other site 1129794008485 Walker B motif; other site 1129794008486 arginine finger; other site 1129794008487 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1129794008488 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1129794008489 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1129794008490 peptide binding site [polypeptide binding]; other site 1129794008491 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1129794008492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794008493 dimer interface [polypeptide binding]; other site 1129794008494 conserved gate region; other site 1129794008495 putative PBP binding loops; other site 1129794008496 ABC-ATPase subunit interface; other site 1129794008497 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 1129794008498 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1129794008499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794008500 dimer interface [polypeptide binding]; other site 1129794008501 ABC-ATPase subunit interface; other site 1129794008502 putative PBP binding loops; other site 1129794008503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794008504 Walker A/P-loop; other site 1129794008505 ATP binding site [chemical binding]; other site 1129794008506 Q-loop/lid; other site 1129794008507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794008508 Walker B; other site 1129794008509 D-loop; other site 1129794008510 H-loop/switch region; other site 1129794008511 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1129794008512 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 1129794008513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1129794008514 Walker A/P-loop; other site 1129794008515 ATP binding site [chemical binding]; other site 1129794008516 Q-loop/lid; other site 1129794008517 ABC transporter signature motif; other site 1129794008518 Walker B; other site 1129794008519 D-loop; other site 1129794008520 H-loop/switch region; other site 1129794008521 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1129794008522 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 1129794008523 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1129794008524 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1129794008525 active site 1129794008526 metal binding site [ion binding]; metal-binding site 1129794008527 homodimer binding site [polypeptide binding]; other site 1129794008528 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1129794008529 carboxyltransferase (CT) interaction site; other site 1129794008530 biotinylation site [posttranslational modification]; other site 1129794008531 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 1129794008532 carbon storage regulator; Provisional; Region: PRK01712 1129794008533 DHHA1 domain; Region: DHHA1; pfam02272 1129794008534 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1129794008535 tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411 1129794008536 motif 1; other site 1129794008537 active site 1129794008538 motif 2; other site 1129794008539 motif 3; other site 1129794008540 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1129794008541 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1129794008542 RecX family; Region: RecX; cl00936 1129794008543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1129794008544 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1129794008545 Protein of unknown function (DUF938); Region: DUF938; pfam06080 1129794008546 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1129794008547 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1129794008548 substrate binding pocket [chemical binding]; other site 1129794008549 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1129794008550 B12 binding site [chemical binding]; other site 1129794008551 cobalt ligand [ion binding]; other site 1129794008552 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1129794008553 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1129794008554 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1129794008555 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1129794008556 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1129794008557 proposed active site lysine [active] 1129794008558 conserved cys residue [active] 1129794008559 Helix-turn-helix domain; Region: HTH_38; pfam13936 1129794008560 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1129794008561 Integrase core domain; Region: rve; pfam00665 1129794008562 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 1129794008563 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1129794008564 putative CheA interaction surface; other site 1129794008565 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1129794008566 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1129794008567 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1129794008568 Magnesium ion binding site [ion binding]; other site 1129794008569 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1129794008570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008571 active site 1129794008572 phosphorylation site [posttranslational modification] 1129794008573 intermolecular recognition site; other site 1129794008574 dimerization interface [polypeptide binding]; other site 1129794008575 CheB methylesterase; Region: CheB_methylest; pfam01339 1129794008576 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1129794008577 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1129794008578 putative binding surface; other site 1129794008579 active site 1129794008580 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1129794008581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794008582 ATP binding site [chemical binding]; other site 1129794008583 Mg2+ binding site [ion binding]; other site 1129794008584 G-X-G motif; other site 1129794008585 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1129794008586 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 1129794008587 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1129794008588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008589 active site 1129794008590 phosphorylation site [posttranslational modification] 1129794008591 intermolecular recognition site; other site 1129794008592 dimerization interface [polypeptide binding]; other site 1129794008593 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1129794008594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794008595 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1129794008596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794008597 DNA binding residues [nucleotide binding] 1129794008598 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1129794008599 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1129794008600 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1129794008601 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1129794008602 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1129794008603 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1129794008604 FHIPEP family; Region: FHIPEP; pfam00771 1129794008605 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1129794008606 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1129794008607 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1129794008608 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1129794008609 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1129794008610 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1129794008611 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1129794008612 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1129794008613 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1129794008614 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 1129794008615 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1129794008616 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1129794008617 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1129794008618 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 1129794008619 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1129794008620 Walker A motif/ATP binding site; other site 1129794008621 Walker B motif; other site 1129794008622 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1129794008623 Flagellar assembly protein FliH; Region: FliH; pfam02108 1129794008624 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1129794008625 MgtE intracellular N domain; Region: MgtE_N; smart00924 1129794008626 FliG C-terminal domain; Region: FliG_C; pfam01706 1129794008627 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1129794008628 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1129794008629 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1129794008630 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1129794008631 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1129794008632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008633 active site 1129794008634 phosphorylation site [posttranslational modification] 1129794008635 intermolecular recognition site; other site 1129794008636 dimerization interface [polypeptide binding]; other site 1129794008637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794008638 Walker A motif; other site 1129794008639 ATP binding site [chemical binding]; other site 1129794008640 Walker B motif; other site 1129794008641 arginine finger; other site 1129794008642 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1129794008643 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1129794008644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1129794008645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794008646 dimer interface [polypeptide binding]; other site 1129794008647 phosphorylation site [posttranslational modification] 1129794008648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794008649 ATP binding site [chemical binding]; other site 1129794008650 Mg2+ binding site [ion binding]; other site 1129794008651 G-X-G motif; other site 1129794008652 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1129794008653 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1129794008654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794008655 Walker A motif; other site 1129794008656 ATP binding site [chemical binding]; other site 1129794008657 Walker B motif; other site 1129794008658 arginine finger; other site 1129794008659 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1129794008660 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1129794008661 flagellin; Provisional; Region: PRK12804 1129794008662 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1129794008663 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1129794008664 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1129794008665 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1129794008666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794008667 S-adenosylmethionine binding site [chemical binding]; other site 1129794008668 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1129794008669 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 1129794008670 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1129794008671 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1129794008672 active site 1129794008673 nucleotide binding site [chemical binding]; other site 1129794008674 HIGH motif; other site 1129794008675 KMSKS motif; other site 1129794008676 LicD family; Region: LicD; pfam04991 1129794008677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794008678 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1129794008679 NAD(P) binding site [chemical binding]; other site 1129794008680 active site 1129794008681 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1129794008682 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794008683 acyl-activating enzyme (AAE) consensus motif; other site 1129794008684 AMP binding site [chemical binding]; other site 1129794008685 active site 1129794008686 CoA binding site [chemical binding]; other site 1129794008687 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1129794008688 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1129794008689 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1129794008690 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1129794008691 pseudaminic acid synthase; Region: PseI; TIGR03586 1129794008692 NeuB family; Region: NeuB; pfam03102 1129794008693 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1129794008694 NeuB binding interface [polypeptide binding]; other site 1129794008695 putative substrate binding site [chemical binding]; other site 1129794008696 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1129794008697 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1129794008698 ligand binding site; other site 1129794008699 tetramer interface; other site 1129794008700 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1129794008701 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1129794008702 inhibitor-cofactor binding pocket; inhibition site 1129794008703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794008704 catalytic residue [active] 1129794008705 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1129794008706 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1129794008707 NAD(P) binding site [chemical binding]; other site 1129794008708 homodimer interface [polypeptide binding]; other site 1129794008709 substrate binding site [chemical binding]; other site 1129794008710 active site 1129794008711 flagellar protein FliS; Validated; Region: fliS; PRK05685 1129794008712 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 1129794008713 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1129794008714 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1129794008715 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1129794008716 FlaG protein; Region: FlaG; pfam03646 1129794008717 flagellin; Provisional; Region: PRK12802 1129794008718 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1129794008719 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1129794008720 flagellin; Provisional; Region: PRK12802 1129794008721 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1129794008722 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1129794008723 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1129794008724 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1129794008725 flagellin; Provisional; Region: PRK12802 1129794008726 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1129794008727 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1129794008728 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1129794008729 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1129794008730 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1129794008731 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 1129794008732 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1129794008733 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1129794008734 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1129794008735 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1129794008736 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1129794008737 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1129794008738 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1129794008739 Flagellar L-ring protein; Region: FlgH; pfam02107 1129794008740 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1129794008741 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1129794008742 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1129794008743 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1129794008744 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1129794008745 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1129794008746 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1129794008747 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1129794008748 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1129794008749 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1129794008750 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1129794008751 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1129794008752 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 1129794008753 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1129794008754 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1129794008755 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1129794008756 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1129794008757 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1129794008758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794008759 S-adenosylmethionine binding site [chemical binding]; other site 1129794008760 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1129794008761 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794008762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008763 active site 1129794008764 phosphorylation site [posttranslational modification] 1129794008765 intermolecular recognition site; other site 1129794008766 dimerization interface [polypeptide binding]; other site 1129794008767 SAF-like; Region: SAF_2; pfam13144 1129794008768 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1129794008769 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1129794008770 LPP20 lipoprotein; Region: LPP20; pfam02169 1129794008771 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1129794008772 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1129794008773 active site 1129794008774 DNA binding site [nucleotide binding] 1129794008775 Int/Topo IB signature motif; other site 1129794008776 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1129794008777 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1129794008778 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1129794008779 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1129794008780 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1129794008781 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1129794008782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794008783 S-adenosylmethionine binding site [chemical binding]; other site 1129794008784 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1129794008785 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1129794008786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794008787 ATP binding site [chemical binding]; other site 1129794008788 putative Mg++ binding site [ion binding]; other site 1129794008789 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1129794008790 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1129794008791 catalytic residues [active] 1129794008792 catalytic nucleophile [active] 1129794008793 Presynaptic Site I dimer interface [polypeptide binding]; other site 1129794008794 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1129794008795 Synaptic Flat tetramer interface [polypeptide binding]; other site 1129794008796 Synaptic Site I dimer interface [polypeptide binding]; other site 1129794008797 DNA binding site [nucleotide binding] 1129794008798 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1129794008799 DNA-binding interface [nucleotide binding]; DNA binding site 1129794008800 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1129794008801 Protein of unknown function (DUF2026); Region: DUF2026; pfam09641 1129794008802 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1129794008803 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1129794008804 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1129794008805 active site 1129794008806 DNA binding site [nucleotide binding] 1129794008807 Int/Topo IB signature motif; other site 1129794008808 Replication initiation factor; Region: Rep_trans; pfam02486 1129794008809 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1129794008810 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1129794008811 putative GSH binding site [chemical binding]; other site 1129794008812 catalytic residues [active] 1129794008813 superoxide dismutase; Provisional; Region: PRK10543 1129794008814 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1129794008815 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1129794008816 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1129794008817 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1129794008818 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1129794008819 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1129794008820 putative active site [active] 1129794008821 putative FMN binding site [chemical binding]; other site 1129794008822 putative substrate binding site [chemical binding]; other site 1129794008823 putative catalytic residue [active] 1129794008824 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1129794008825 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1129794008826 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794008827 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1129794008828 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794008829 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1129794008830 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1129794008831 active site 1129794008832 FMN binding site [chemical binding]; other site 1129794008833 2,4-decadienoyl-CoA binding site; other site 1129794008834 catalytic residue [active] 1129794008835 4Fe-4S cluster binding site [ion binding]; other site 1129794008836 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1129794008837 enoyl-CoA hydratase; Provisional; Region: PRK06142 1129794008838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794008839 substrate binding site [chemical binding]; other site 1129794008840 oxyanion hole (OAH) forming residues; other site 1129794008841 trimer interface [polypeptide binding]; other site 1129794008842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794008843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794008844 WHG domain; Region: WHG; pfam13305 1129794008845 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 1129794008846 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1129794008847 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1129794008848 ligand binding site [chemical binding]; other site 1129794008849 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1129794008850 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1129794008851 dimer interface [polypeptide binding]; other site 1129794008852 catalytic site [active] 1129794008853 putative active site [active] 1129794008854 putative substrate binding site [chemical binding]; other site 1129794008855 peroxidase; Provisional; Region: PRK15000 1129794008856 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1129794008857 dimer interface [polypeptide binding]; other site 1129794008858 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1129794008859 catalytic triad [active] 1129794008860 peroxidatic and resolving cysteines [active] 1129794008861 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1129794008862 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1129794008863 Zn binding site [ion binding]; other site 1129794008864 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 1129794008865 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1129794008866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1129794008867 Smr domain; Region: Smr; pfam01713 1129794008868 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1129794008869 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1129794008870 dimerization interface [polypeptide binding]; other site 1129794008871 ATP binding site [chemical binding]; other site 1129794008872 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1129794008873 dimerization interface [polypeptide binding]; other site 1129794008874 ATP binding site [chemical binding]; other site 1129794008875 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1129794008876 putative active site [active] 1129794008877 catalytic triad [active] 1129794008878 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1129794008879 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1129794008880 substrate binding pocket [chemical binding]; other site 1129794008881 membrane-bound complex binding site; other site 1129794008882 hinge residues; other site 1129794008883 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794008884 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1129794008885 catalytic residue [active] 1129794008886 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1129794008887 nucleoside/Zn binding site; other site 1129794008888 dimer interface [polypeptide binding]; other site 1129794008889 catalytic motif [active] 1129794008890 phage shock protein C; Region: phageshock_pspC; TIGR02978 1129794008891 PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279 1129794008892 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1129794008893 Trp docking motif [polypeptide binding]; other site 1129794008894 cytochrome domain interface [polypeptide binding]; other site 1129794008895 active site 1129794008896 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1129794008897 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1129794008898 putative acyl-acceptor binding pocket; other site 1129794008899 YaeQ protein; Region: YaeQ; cl01913 1129794008900 YaeQ protein; Region: YaeQ; cl01913 1129794008901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794008902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794008903 Coenzyme A binding pocket [chemical binding]; other site 1129794008904 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1129794008905 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1129794008906 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1129794008907 AMP/PPi binding site [chemical binding]; other site 1129794008908 candidate oxyanion hole; other site 1129794008909 catalytic triad [active] 1129794008910 potential glutamine specificity residues [chemical binding]; other site 1129794008911 GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519 1129794008912 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1129794008913 ATP Binding subdomain [chemical binding]; other site 1129794008914 Ligand Binding sites [chemical binding]; other site 1129794008915 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1129794008916 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1129794008917 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1129794008918 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1129794008919 active site 1129794008920 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1129794008921 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1129794008922 generic binding surface II; other site 1129794008923 generic binding surface I; other site 1129794008924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794008925 active site 1129794008926 phosphorylation site [posttranslational modification] 1129794008927 intermolecular recognition site; other site 1129794008928 dimerization interface [polypeptide binding]; other site 1129794008929 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794008930 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794008931 metal binding site [ion binding]; metal-binding site 1129794008932 active site 1129794008933 I-site; other site 1129794008934 GTP-binding protein Der; Reviewed; Region: PRK00093 1129794008935 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1129794008936 G1 box; other site 1129794008937 GTP/Mg2+ binding site [chemical binding]; other site 1129794008938 Switch I region; other site 1129794008939 G2 box; other site 1129794008940 Switch II region; other site 1129794008941 G3 box; other site 1129794008942 G4 box; other site 1129794008943 G5 box; other site 1129794008944 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1129794008945 G1 box; other site 1129794008946 GTP/Mg2+ binding site [chemical binding]; other site 1129794008947 Switch I region; other site 1129794008948 G2 box; other site 1129794008949 G3 box; other site 1129794008950 Switch II region; other site 1129794008951 G4 box; other site 1129794008952 G5 box; other site 1129794008953 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1129794008954 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1129794008955 Trp docking motif [polypeptide binding]; other site 1129794008956 active site 1129794008957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1129794008958 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1129794008959 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1129794008960 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1129794008961 dimer interface [polypeptide binding]; other site 1129794008962 motif 1; other site 1129794008963 active site 1129794008964 motif 2; other site 1129794008965 motif 3; other site 1129794008966 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1129794008967 anticodon binding site; other site 1129794008968 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1129794008969 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1129794008970 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1129794008971 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1129794008972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794008973 non-specific DNA binding site [nucleotide binding]; other site 1129794008974 salt bridge; other site 1129794008975 sequence-specific DNA binding site [nucleotide binding]; other site 1129794008976 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1129794008977 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1129794008978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794008979 TPR motif; other site 1129794008980 binding surface 1129794008981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794008982 binding surface 1129794008983 TPR motif; other site 1129794008984 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1129794008985 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1129794008986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794008987 FeS/SAM binding site; other site 1129794008988 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1129794008989 active site 1129794008990 multimer interface [polypeptide binding]; other site 1129794008991 periplasmic folding chaperone; Provisional; Region: PRK10788 1129794008992 SurA N-terminal domain; Region: SurA_N_3; cl07813 1129794008993 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1129794008994 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1129794008995 IHF - DNA interface [nucleotide binding]; other site 1129794008996 IHF dimer interface [polypeptide binding]; other site 1129794008997 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1129794008998 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1129794008999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794009000 Walker A motif; other site 1129794009001 ATP binding site [chemical binding]; other site 1129794009002 Walker B motif; other site 1129794009003 arginine finger; other site 1129794009004 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1129794009005 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1129794009006 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1129794009007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794009008 Walker A motif; other site 1129794009009 ATP binding site [chemical binding]; other site 1129794009010 Walker B motif; other site 1129794009011 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1129794009012 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1129794009013 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1129794009014 oligomer interface [polypeptide binding]; other site 1129794009015 active site residues [active] 1129794009016 trigger factor; Provisional; Region: tig; PRK01490 1129794009017 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794009018 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1129794009019 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1129794009020 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1129794009021 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1129794009022 homodimer interface [polypeptide binding]; other site 1129794009023 NADP binding site [chemical binding]; other site 1129794009024 substrate binding site [chemical binding]; other site 1129794009025 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 1129794009026 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1129794009027 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1129794009028 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1129794009029 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1129794009030 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1129794009031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794009032 Walker A/P-loop; other site 1129794009033 ATP binding site [chemical binding]; other site 1129794009034 Q-loop/lid; other site 1129794009035 ABC transporter signature motif; other site 1129794009036 Walker B; other site 1129794009037 D-loop; other site 1129794009038 H-loop/switch region; other site 1129794009039 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1129794009040 active site 1129794009041 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1129794009042 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1129794009043 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1129794009044 GTPase Era; Reviewed; Region: era; PRK00089 1129794009045 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1129794009046 G1 box; other site 1129794009047 GTP/Mg2+ binding site [chemical binding]; other site 1129794009048 Switch I region; other site 1129794009049 G2 box; other site 1129794009050 Switch II region; other site 1129794009051 G3 box; other site 1129794009052 G4 box; other site 1129794009053 G5 box; other site 1129794009054 KH domain; Region: KH_2; pfam07650 1129794009055 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1129794009056 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1129794009057 dimerization interface [polypeptide binding]; other site 1129794009058 active site 1129794009059 metal binding site [ion binding]; metal-binding site 1129794009060 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1129794009061 dsRNA binding site [nucleotide binding]; other site 1129794009062 signal peptidase I; Provisional; Region: PRK10861 1129794009063 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1129794009064 Catalytic site [active] 1129794009065 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1129794009066 GTP-binding protein LepA; Provisional; Region: PRK05433 1129794009067 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1129794009068 G1 box; other site 1129794009069 putative GEF interaction site [polypeptide binding]; other site 1129794009070 GTP/Mg2+ binding site [chemical binding]; other site 1129794009071 Switch I region; other site 1129794009072 G2 box; other site 1129794009073 G3 box; other site 1129794009074 Switch II region; other site 1129794009075 G4 box; other site 1129794009076 G5 box; other site 1129794009077 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1129794009078 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1129794009079 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1129794009080 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 1129794009081 MucB/RseB family; Region: MucB_RseB; pfam03888 1129794009082 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1129794009083 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1129794009084 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1129794009085 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1129794009086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794009087 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794009088 DNA binding residues [nucleotide binding] 1129794009089 L-aspartate oxidase; Provisional; Region: PRK09077 1129794009090 L-aspartate oxidase; Provisional; Region: PRK06175 1129794009091 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1129794009092 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1129794009093 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1129794009094 putative global regulator; Reviewed; Region: PRK09559 1129794009095 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1129794009096 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1129794009097 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794009098 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1129794009099 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1129794009100 PEP-CTERM motif; Region: VPEP; pfam07589 1129794009101 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1129794009102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794009103 binding surface 1129794009104 TPR motif; other site 1129794009105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794009106 TPR motif; other site 1129794009107 binding surface 1129794009108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794009109 binding surface 1129794009110 TPR motif; other site 1129794009111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1129794009112 TPR motif; other site 1129794009113 binding surface 1129794009114 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1129794009115 Clp amino terminal domain; Region: Clp_N; pfam02861 1129794009116 Clp amino terminal domain; Region: Clp_N; pfam02861 1129794009117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794009118 Walker A motif; other site 1129794009119 ATP binding site [chemical binding]; other site 1129794009120 Walker B motif; other site 1129794009121 arginine finger; other site 1129794009122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794009123 Walker A motif; other site 1129794009124 ATP binding site [chemical binding]; other site 1129794009125 Walker B motif; other site 1129794009126 arginine finger; other site 1129794009127 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1129794009128 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1129794009129 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1129794009130 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1129794009131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1129794009132 RNA binding surface [nucleotide binding]; other site 1129794009133 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1129794009134 active site 1129794009135 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1129794009136 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 1129794009137 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1129794009138 RNA polymerase sigma factor; Provisional; Region: PRK11924 1129794009139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794009140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794009141 DNA binding residues [nucleotide binding] 1129794009142 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1129794009143 Sphingolipid Delta4-desaturase (DES); Region: Lipid_DES; pfam08557 1129794009144 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1129794009145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1129794009146 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1129794009147 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1129794009148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794009149 S-adenosylmethionine binding site [chemical binding]; other site 1129794009150 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1129794009151 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1129794009152 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 1129794009153 tetramerization interface [polypeptide binding]; other site 1129794009154 substrate binding pocket [chemical binding]; other site 1129794009155 catalytic residues [active] 1129794009156 inhibitor binding sites; inhibition site 1129794009157 NADP(H) binding site [chemical binding]; other site 1129794009158 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 1129794009159 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1129794009160 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1129794009161 ligand binding site [chemical binding]; other site 1129794009162 flagellar motor protein PomA; Reviewed; Region: PRK08990 1129794009163 flagellar motor protein MotP; Reviewed; Region: PRK06743 1129794009164 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1129794009165 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1129794009166 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1129794009167 substrate binding pocket [chemical binding]; other site 1129794009168 chain length determination region; other site 1129794009169 substrate-Mg2+ binding site; other site 1129794009170 catalytic residues [active] 1129794009171 aspartate-rich region 1; other site 1129794009172 active site lid residues [active] 1129794009173 aspartate-rich region 2; other site 1129794009174 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1129794009175 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1129794009176 TPP-binding site; other site 1129794009177 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1129794009178 PYR/PP interface [polypeptide binding]; other site 1129794009179 dimer interface [polypeptide binding]; other site 1129794009180 TPP binding site [chemical binding]; other site 1129794009181 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1129794009182 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1129794009183 tetramer interfaces [polypeptide binding]; other site 1129794009184 binuclear metal-binding site [ion binding]; other site 1129794009185 thiamine monophosphate kinase; Provisional; Region: PRK05731 1129794009186 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1129794009187 ATP binding site [chemical binding]; other site 1129794009188 dimerization interface [polypeptide binding]; other site 1129794009189 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1129794009190 putative RNA binding site [nucleotide binding]; other site 1129794009191 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1129794009192 homopentamer interface [polypeptide binding]; other site 1129794009193 active site 1129794009194 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1129794009195 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1129794009196 dimerization interface [polypeptide binding]; other site 1129794009197 active site 1129794009198 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1129794009199 Lumazine binding domain; Region: Lum_binding; pfam00677 1129794009200 Lumazine binding domain; Region: Lum_binding; pfam00677 1129794009201 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1129794009202 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1129794009203 catalytic motif [active] 1129794009204 Zn binding site [ion binding]; other site 1129794009205 RibD C-terminal domain; Region: RibD_C; cl17279 1129794009206 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1129794009207 ATP cone domain; Region: ATP-cone; pfam03477 1129794009208 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1129794009209 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1129794009210 dimer interface [polypeptide binding]; other site 1129794009211 active site 1129794009212 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1129794009213 folate binding site [chemical binding]; other site 1129794009214 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1129794009215 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1129794009216 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1129794009217 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1129794009218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794009219 Walker A/P-loop; other site 1129794009220 ATP binding site [chemical binding]; other site 1129794009221 Q-loop/lid; other site 1129794009222 ABC transporter signature motif; other site 1129794009223 Walker B; other site 1129794009224 D-loop; other site 1129794009225 H-loop/switch region; other site 1129794009226 ABC transporter; Region: ABC_tran_2; pfam12848 1129794009227 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794009228 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1129794009229 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1129794009230 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1129794009231 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1129794009232 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1129794009233 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1129794009234 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1129794009235 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1129794009236 Homeodomain-like domain; Region: HTH_32; pfam13565 1129794009237 Integrase core domain; Region: rve; pfam00665 1129794009238 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1129794009239 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1129794009240 active site 1129794009241 nucleophile elbow; other site 1129794009242 DNA repair protein RadA; Provisional; Region: PRK11823 1129794009243 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1129794009244 Walker A motif/ATP binding site; other site 1129794009245 ATP binding site [chemical binding]; other site 1129794009246 Walker B motif; other site 1129794009247 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1129794009248 PilZ domain; Region: PilZ; pfam07238 1129794009249 PilZ domain; Region: PilZ; pfam07238 1129794009250 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1129794009251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794009252 motif II; other site 1129794009253 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1129794009254 homodimer interaction site [polypeptide binding]; other site 1129794009255 cofactor binding site; other site 1129794009256 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1129794009257 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1129794009258 dimer interface [polypeptide binding]; other site 1129794009259 motif 1; other site 1129794009260 active site 1129794009261 motif 2; other site 1129794009262 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1129794009263 putative deacylase active site [active] 1129794009264 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1129794009265 active site 1129794009266 motif 3; other site 1129794009267 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1129794009268 anticodon binding site; other site 1129794009269 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1129794009270 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1129794009271 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1129794009272 nucleophile elbow; other site 1129794009273 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1129794009274 CoenzymeA binding site [chemical binding]; other site 1129794009275 subunit interaction site [polypeptide binding]; other site 1129794009276 PHB binding site; other site 1129794009277 Integrase core domain; Region: rve_3; cl15866 1129794009278 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1129794009279 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1129794009280 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1129794009281 EamA-like transporter family; Region: EamA; cl17759 1129794009282 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794009283 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1129794009284 methionine sulfoxide reductase A; Provisional; Region: PRK05528 1129794009285 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1129794009286 ATP phosphoribosyltransferase; Region: HisG; cl15266 1129794009287 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1129794009288 ATP phosphoribosyltransferase; Region: HisG; cl15266 1129794009289 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1129794009290 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1129794009291 histidinol dehydrogenase; Region: hisD; TIGR00069 1129794009292 NAD binding site [chemical binding]; other site 1129794009293 dimerization interface [polypeptide binding]; other site 1129794009294 product binding site; other site 1129794009295 substrate binding site [chemical binding]; other site 1129794009296 zinc binding site [ion binding]; other site 1129794009297 catalytic residues [active] 1129794009298 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1129794009299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1129794009300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794009301 homodimer interface [polypeptide binding]; other site 1129794009302 catalytic residue [active] 1129794009303 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1129794009304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794009305 active site 1129794009306 motif I; other site 1129794009307 motif II; other site 1129794009308 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1129794009309 putative active site pocket [active] 1129794009310 4-fold oligomerization interface [polypeptide binding]; other site 1129794009311 metal binding residues [ion binding]; metal-binding site 1129794009312 3-fold/trimer interface [polypeptide binding]; other site 1129794009313 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1129794009314 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1129794009315 putative active site [active] 1129794009316 oxyanion strand; other site 1129794009317 catalytic triad [active] 1129794009318 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1129794009319 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1129794009320 catalytic residues [active] 1129794009321 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1129794009322 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1129794009323 homodimer interface [polypeptide binding]; other site 1129794009324 substrate-cofactor binding pocket; other site 1129794009325 catalytic residue [active] 1129794009326 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1129794009327 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1129794009328 substrate binding site [chemical binding]; other site 1129794009329 glutamase interaction surface [polypeptide binding]; other site 1129794009330 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1129794009331 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1129794009332 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1129794009333 metal binding site [ion binding]; metal-binding site 1129794009334 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1129794009335 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1129794009336 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1129794009337 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1129794009338 CHRD domain; Region: CHRD; pfam07452 1129794009339 CHRD domain; Region: CHRD; pfam07452 1129794009340 CHRD domain; Region: CHRD; pfam07452 1129794009341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794009342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794009343 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794009344 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794009345 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794009346 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794009347 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1129794009348 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1129794009349 NAD(P) binding site [chemical binding]; other site 1129794009350 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1129794009351 Phosphotransferase enzyme family; Region: APH; pfam01636 1129794009352 putative active site [active] 1129794009353 putative substrate binding site [chemical binding]; other site 1129794009354 ATP binding site [chemical binding]; other site 1129794009355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1129794009356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794009357 active site 1129794009358 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1129794009359 catalytic core [active] 1129794009360 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1129794009361 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794009362 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794009363 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794009364 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794009365 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1129794009366 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1129794009367 catalytic residues [active] 1129794009368 dimer interface [polypeptide binding]; other site 1129794009369 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1129794009370 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1129794009371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794009372 FeS/SAM binding site; other site 1129794009373 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1129794009374 Predicted permeases [General function prediction only]; Region: COG0679 1129794009375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1129794009376 Family of unknown function (DUF490); Region: DUF490; pfam04357 1129794009377 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1129794009378 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1129794009379 Surface antigen; Region: Bac_surface_Ag; pfam01103 1129794009380 aldose dehydrogenase; Validated; Region: PRK06398 1129794009381 classical (c) SDRs; Region: SDR_c; cd05233 1129794009382 NAD(P) binding site [chemical binding]; other site 1129794009383 active site 1129794009384 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1129794009385 Amidohydrolase; Region: Amidohydro_2; pfam04909 1129794009386 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1129794009387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794009388 substrate binding site [chemical binding]; other site 1129794009389 oxyanion hole (OAH) forming residues; other site 1129794009390 trimer interface [polypeptide binding]; other site 1129794009391 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794009392 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794009393 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1129794009394 active site 1129794009395 Protein with unknown function (DUF469); Region: DUF469; pfam04320 1129794009396 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1129794009397 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1129794009398 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1129794009399 substrate binding site [chemical binding]; other site 1129794009400 catalytic Zn binding site [ion binding]; other site 1129794009401 NAD binding site [chemical binding]; other site 1129794009402 structural Zn binding site [ion binding]; other site 1129794009403 dimer interface [polypeptide binding]; other site 1129794009404 S-formylglutathione hydrolase; Region: PLN02442 1129794009405 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1129794009406 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1129794009407 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 1129794009408 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794009409 active site 1129794009410 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1129794009411 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1129794009412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794009413 NAD(P) binding site [chemical binding]; other site 1129794009414 active site 1129794009415 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1129794009416 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1129794009417 active site pocket [active] 1129794009418 aldolase II superfamily protein; Provisional; Region: PRK07044 1129794009419 intersubunit interface [polypeptide binding]; other site 1129794009420 active site 1129794009421 Zn2+ binding site [ion binding]; other site 1129794009422 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1129794009423 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1129794009424 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1129794009425 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1129794009426 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1129794009427 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1129794009428 nudix motif; other site 1129794009429 NIPSNAP; Region: NIPSNAP; pfam07978 1129794009430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1129794009431 DNA binding site [nucleotide binding] 1129794009432 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1129794009433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1129794009434 dimerization interface [polypeptide binding]; other site 1129794009435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794009436 dimer interface [polypeptide binding]; other site 1129794009437 putative CheW interface [polypeptide binding]; other site 1129794009438 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1129794009439 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1129794009440 RNA binding surface [nucleotide binding]; other site 1129794009441 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1129794009442 probable active site [active] 1129794009443 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1129794009444 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1129794009445 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1129794009446 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1129794009447 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1129794009448 active site 1129794009449 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1129794009450 anthranilate synthase component I; Provisional; Region: PRK13564 1129794009451 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1129794009452 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1129794009453 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1129794009454 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1129794009455 glutamine binding [chemical binding]; other site 1129794009456 catalytic triad [active] 1129794009457 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1129794009458 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1129794009459 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1129794009460 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1129794009461 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1129794009462 active site 1129794009463 ribulose/triose binding site [chemical binding]; other site 1129794009464 phosphate binding site [ion binding]; other site 1129794009465 substrate (anthranilate) binding pocket [chemical binding]; other site 1129794009466 product (indole) binding pocket [chemical binding]; other site 1129794009467 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1129794009468 active site 1129794009469 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1129794009470 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1129794009471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794009472 catalytic residue [active] 1129794009473 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1129794009474 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1129794009475 substrate binding site [chemical binding]; other site 1129794009476 active site 1129794009477 catalytic residues [active] 1129794009478 heterodimer interface [polypeptide binding]; other site 1129794009479 YciI-like protein; Reviewed; Region: PRK11370 1129794009480 hypothetical protein; Provisional; Region: PRK09256 1129794009481 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794009482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794009483 active site 1129794009484 phosphorylation site [posttranslational modification] 1129794009485 intermolecular recognition site; other site 1129794009486 dimerization interface [polypeptide binding]; other site 1129794009487 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794009488 DNA binding site [nucleotide binding] 1129794009489 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1129794009490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794009491 ATP binding site [chemical binding]; other site 1129794009492 Mg2+ binding site [ion binding]; other site 1129794009493 G-X-G motif; other site 1129794009494 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1129794009495 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1129794009496 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1129794009497 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1129794009498 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase; Provisional; Region: folX; PRK11245 1129794009499 active site 1129794009500 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1129794009501 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1129794009502 putative NAD(P) binding site [chemical binding]; other site 1129794009503 putative active site [active] 1129794009504 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1129794009505 FtsX-like permease family; Region: FtsX; pfam02687 1129794009506 FtsX-like permease family; Region: FtsX; pfam02687 1129794009507 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1129794009508 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1129794009509 Walker A/P-loop; other site 1129794009510 ATP binding site [chemical binding]; other site 1129794009511 Q-loop/lid; other site 1129794009512 ABC transporter signature motif; other site 1129794009513 Walker B; other site 1129794009514 D-loop; other site 1129794009515 H-loop/switch region; other site 1129794009516 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1129794009517 active site 1129794009518 catalytic triad [active] 1129794009519 oxyanion hole [active] 1129794009520 switch loop; other site 1129794009521 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1129794009522 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794009523 active site 1129794009524 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1129794009525 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1129794009526 active site 1129794009527 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1129794009528 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1129794009529 FMN binding site [chemical binding]; other site 1129794009530 active site 1129794009531 catalytic residues [active] 1129794009532 substrate binding site [chemical binding]; other site 1129794009533 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 1129794009534 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794009535 active site 1129794009536 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1129794009537 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1129794009538 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1129794009539 HIGH motif; other site 1129794009540 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1129794009541 active site 1129794009542 KMSKS motif; other site 1129794009543 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794009544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794009545 active site 1129794009546 phosphorylation site [posttranslational modification] 1129794009547 intermolecular recognition site; other site 1129794009548 dimerization interface [polypeptide binding]; other site 1129794009549 short chain dehydrogenase; Provisional; Region: PRK06123 1129794009550 classical (c) SDRs; Region: SDR_c; cd05233 1129794009551 NAD(P) binding site [chemical binding]; other site 1129794009552 active site 1129794009553 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 1129794009554 kynureninase; Region: kynureninase; TIGR01814 1129794009555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794009556 catalytic residue [active] 1129794009557 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1129794009558 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1129794009559 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1129794009560 dimer interface [polypeptide binding]; other site 1129794009561 active site 1129794009562 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1129794009563 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1129794009564 DNA binding residues [nucleotide binding] 1129794009565 putative dimer interface [polypeptide binding]; other site 1129794009566 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1129794009567 isovaleryl-CoA dehydrogenase; Region: PLN02519 1129794009568 substrate binding site [chemical binding]; other site 1129794009569 FAD binding site [chemical binding]; other site 1129794009570 catalytic base [active] 1129794009571 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1129794009572 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1129794009573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794009574 enoyl-CoA hydratase; Provisional; Region: PRK05995 1129794009575 substrate binding site [chemical binding]; other site 1129794009576 oxyanion hole (OAH) forming residues; other site 1129794009577 trimer interface [polypeptide binding]; other site 1129794009578 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1129794009579 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1129794009580 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794009581 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1129794009582 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1129794009583 carboxyltransferase (CT) interaction site; other site 1129794009584 biotinylation site [posttranslational modification]; other site 1129794009585 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1129794009586 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1129794009587 active site 1129794009588 catalytic residues [active] 1129794009589 metal binding site [ion binding]; metal-binding site 1129794009590 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1129794009591 amidase; Provisional; Region: PRK07486 1129794009592 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1129794009593 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1129794009594 ligand binding site; other site 1129794009595 oligomer interface; other site 1129794009596 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1129794009597 dimer interface [polypeptide binding]; other site 1129794009598 N-terminal domain interface [polypeptide binding]; other site 1129794009599 sulfate 1 binding site; other site 1129794009600 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794009601 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1129794009602 catalytic site [active] 1129794009603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794009604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794009605 putative substrate translocation pore; other site 1129794009606 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1129794009607 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1129794009608 active site 1129794009609 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1129794009610 active site 2 [active] 1129794009611 active site 1 [active] 1129794009612 HDOD domain; Region: HDOD; pfam08668 1129794009613 HDOD domain; Region: HDOD; pfam08668 1129794009614 tol-pal system protein YbgF; Provisional; Region: PRK10803 1129794009615 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1129794009616 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1129794009617 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1129794009618 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1129794009619 ligand binding site [chemical binding]; other site 1129794009620 translocation protein TolB; Provisional; Region: tolB; PRK04792 1129794009621 TolB amino-terminal domain; Region: TolB_N; pfam04052 1129794009622 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794009623 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794009624 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794009625 TolA protein; Region: tolA_full; TIGR02794 1129794009626 TolA protein; Region: tolA_full; TIGR02794 1129794009627 TolA C-terminal; Region: TolA; pfam06519 1129794009628 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1129794009629 TolR protein; Region: tolR; TIGR02801 1129794009630 TolQ protein; Region: tolQ; TIGR02796 1129794009631 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1129794009632 active site 1129794009633 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1129794009634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794009635 Walker A motif; other site 1129794009636 ATP binding site [chemical binding]; other site 1129794009637 Walker B motif; other site 1129794009638 arginine finger; other site 1129794009639 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1129794009640 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1129794009641 RuvA N terminal domain; Region: RuvA_N; pfam01330 1129794009642 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1129794009643 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1129794009644 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1129794009645 active site 1129794009646 NAD binding site [chemical binding]; other site 1129794009647 metal binding site [ion binding]; metal-binding site 1129794009648 PAS domain S-box; Region: sensory_box; TIGR00229 1129794009649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794009650 putative active site [active] 1129794009651 heme pocket [chemical binding]; other site 1129794009652 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1129794009653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794009654 Walker A motif; other site 1129794009655 ATP binding site [chemical binding]; other site 1129794009656 Walker B motif; other site 1129794009657 arginine finger; other site 1129794009658 succinic semialdehyde dehydrogenase; Region: PLN02278 1129794009659 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1129794009660 tetramerization interface [polypeptide binding]; other site 1129794009661 NAD(P) binding site [chemical binding]; other site 1129794009662 catalytic residues [active] 1129794009663 Putative cyclase; Region: Cyclase; pfam04199 1129794009664 Gram-negative porin; Region: Porin_4; pfam13609 1129794009665 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1129794009666 active site 1129794009667 putative DNA-binding cleft [nucleotide binding]; other site 1129794009668 dimer interface [polypeptide binding]; other site 1129794009669 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1129794009670 nudix motif; other site 1129794009671 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1129794009672 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1129794009673 dimer interface [polypeptide binding]; other site 1129794009674 anticodon binding site; other site 1129794009675 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1129794009676 homodimer interface [polypeptide binding]; other site 1129794009677 motif 1; other site 1129794009678 active site 1129794009679 motif 2; other site 1129794009680 GAD domain; Region: GAD; pfam02938 1129794009681 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1129794009682 active site 1129794009683 motif 3; other site 1129794009684 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1129794009685 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1129794009686 Walker A/P-loop; other site 1129794009687 ATP binding site [chemical binding]; other site 1129794009688 Q-loop/lid; other site 1129794009689 ABC transporter signature motif; other site 1129794009690 Walker B; other site 1129794009691 D-loop; other site 1129794009692 H-loop/switch region; other site 1129794009693 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1129794009694 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1129794009695 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1129794009696 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1129794009697 Zn binding site [ion binding]; other site 1129794009698 transcription elongation factor NusA-like protein; Validated; Region: PRK08406 1129794009699 Protein of unknown function DUF72; Region: DUF72; cl00777 1129794009700 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1129794009701 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1129794009702 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1129794009703 Phytase; Region: Phytase; cl17685 1129794009704 Phytase; Region: Phytase; cl17685 1129794009705 Phytase; Region: Phytase; cl17685 1129794009706 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 1129794009707 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1129794009708 active site 1129794009709 metal binding site [ion binding]; metal-binding site 1129794009710 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1129794009711 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1129794009712 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794009713 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794009714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794009715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794009716 metal binding site [ion binding]; metal-binding site 1129794009717 active site 1129794009718 I-site; other site 1129794009719 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794009720 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794009721 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1129794009722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1129794009723 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1129794009724 FecR protein; Region: FecR; pfam04773 1129794009725 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794009726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794009727 N-terminal plug; other site 1129794009728 ligand-binding site [chemical binding]; other site 1129794009729 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1129794009730 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1129794009731 active site 1129794009732 metal binding site [ion binding]; metal-binding site 1129794009733 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1129794009734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794009735 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1129794009736 putative dimerization interface [polypeptide binding]; other site 1129794009737 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1129794009738 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1129794009739 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794009740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794009741 active site 1129794009742 phosphorylation site [posttranslational modification] 1129794009743 intermolecular recognition site; other site 1129794009744 dimerization interface [polypeptide binding]; other site 1129794009745 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1129794009746 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1129794009747 Ligand Binding Site [chemical binding]; other site 1129794009748 TilS substrate binding domain; Region: TilS; pfam09179 1129794009749 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1129794009750 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1129794009751 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1129794009752 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1129794009753 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1129794009754 putative active site [active] 1129794009755 putative PHP Thumb interface [polypeptide binding]; other site 1129794009756 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1129794009757 generic binding surface I; other site 1129794009758 generic binding surface II; other site 1129794009759 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1129794009760 RNA/DNA hybrid binding site [nucleotide binding]; other site 1129794009761 active site 1129794009762 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1129794009763 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1129794009764 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1129794009765 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1129794009766 active site 1129794009767 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1129794009768 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1129794009769 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1129794009770 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1129794009771 trimer interface [polypeptide binding]; other site 1129794009772 active site 1129794009773 UDP-GlcNAc binding site [chemical binding]; other site 1129794009774 lipid binding site [chemical binding]; lipid-binding site 1129794009775 periplasmic chaperone; Provisional; Region: PRK10780 1129794009776 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1129794009777 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1129794009778 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1129794009779 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1129794009780 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1129794009781 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1129794009782 Surface antigen; Region: Bac_surface_Ag; pfam01103 1129794009783 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1129794009784 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1129794009785 active site 1129794009786 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1129794009787 protein binding site [polypeptide binding]; other site 1129794009788 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1129794009789 putative substrate binding region [chemical binding]; other site 1129794009790 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1129794009791 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1129794009792 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1129794009793 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1129794009794 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1129794009795 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1129794009796 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1129794009797 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1129794009798 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1129794009799 catalytic residue [active] 1129794009800 putative FPP diphosphate binding site; other site 1129794009801 putative FPP binding hydrophobic cleft; other site 1129794009802 dimer interface [polypeptide binding]; other site 1129794009803 putative IPP diphosphate binding site; other site 1129794009804 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1129794009805 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1129794009806 hinge region; other site 1129794009807 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1129794009808 putative nucleotide binding site [chemical binding]; other site 1129794009809 uridine monophosphate binding site [chemical binding]; other site 1129794009810 homohexameric interface [polypeptide binding]; other site 1129794009811 elongation factor Ts; Provisional; Region: tsf; PRK09377 1129794009812 UBA/TS-N domain; Region: UBA; pfam00627 1129794009813 Elongation factor TS; Region: EF_TS; pfam00889 1129794009814 Elongation factor TS; Region: EF_TS; pfam00889 1129794009815 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1129794009816 rRNA interaction site [nucleotide binding]; other site 1129794009817 S8 interaction site; other site 1129794009818 putative laminin-1 binding site; other site 1129794009819 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1129794009820 active site 1129794009821 PII uridylyl-transferase; Provisional; Region: PRK05007 1129794009822 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1129794009823 metal binding triad; other site 1129794009824 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1129794009825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794009826 Zn2+ binding site [ion binding]; other site 1129794009827 Mg2+ binding site [ion binding]; other site 1129794009828 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1129794009829 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1129794009830 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1129794009831 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1129794009832 putative acyl-acceptor binding pocket; other site 1129794009833 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1129794009834 YebG protein; Region: YebG; pfam07130 1129794009835 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1129794009836 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794009837 catalytic loop [active] 1129794009838 iron binding site [ion binding]; other site 1129794009839 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1129794009840 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1129794009841 nucleotide binding site [chemical binding]; other site 1129794009842 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1129794009843 SBD interface [polypeptide binding]; other site 1129794009844 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1129794009845 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1129794009846 HSP70 interaction site [polypeptide binding]; other site 1129794009847 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1129794009848 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1129794009849 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1129794009850 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1129794009851 trimerization site [polypeptide binding]; other site 1129794009852 active site 1129794009853 cysteine desulfurase; Provisional; Region: PRK14012 1129794009854 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1129794009855 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794009856 catalytic residue [active] 1129794009857 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1129794009858 Rrf2 family protein; Region: rrf2_super; TIGR00738 1129794009859 serine O-acetyltransferase; Region: cysE; TIGR01172 1129794009860 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1129794009861 trimer interface [polypeptide binding]; other site 1129794009862 active site 1129794009863 substrate binding site [chemical binding]; other site 1129794009864 CoA binding site [chemical binding]; other site 1129794009865 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1129794009866 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1129794009867 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1129794009868 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1129794009869 active site 1129794009870 dimerization interface [polypeptide binding]; other site 1129794009871 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1129794009872 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1129794009873 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794009874 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1129794009875 Outer membrane efflux protein; Region: OEP; pfam02321 1129794009876 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1129794009877 protease3; Provisional; Region: PRK15101 1129794009878 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1129794009879 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794009880 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794009881 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1129794009882 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1129794009883 Protein export membrane protein; Region: SecD_SecF; pfam02355 1129794009884 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1129794009885 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1129794009886 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1129794009887 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1129794009888 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1129794009889 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1129794009890 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1129794009891 HAMP domain; Region: HAMP; pfam00672 1129794009892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794009893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794009894 metal binding site [ion binding]; metal-binding site 1129794009895 active site 1129794009896 I-site; other site 1129794009897 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1129794009898 substrate binding pocket [chemical binding]; other site 1129794009899 membrane-bound complex binding site; other site 1129794009900 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1129794009901 HAMP domain; Region: HAMP; pfam00672 1129794009902 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1129794009903 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1129794009904 dimer interface [polypeptide binding]; other site 1129794009905 putative CheW interface [polypeptide binding]; other site 1129794009906 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1129794009907 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1129794009908 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 1129794009909 PspA/IM30 family; Region: PspA_IM30; pfam04012 1129794009910 Ion channel; Region: Ion_trans_2; pfam07885 1129794009911 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1129794009912 Predicted membrane protein [Function unknown]; Region: COG3766 1129794009913 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1129794009914 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 1129794009915 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1129794009916 Rhomboid family; Region: Rhomboid; pfam01694 1129794009917 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1129794009918 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1129794009919 Walker A/P-loop; other site 1129794009920 ATP binding site [chemical binding]; other site 1129794009921 Q-loop/lid; other site 1129794009922 ABC transporter signature motif; other site 1129794009923 Walker B; other site 1129794009924 D-loop; other site 1129794009925 H-loop/switch region; other site 1129794009926 FtsX-like permease family; Region: FtsX; pfam02687 1129794009927 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 1129794009928 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1129794009929 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1129794009930 dimer interface [polypeptide binding]; other site 1129794009931 active site 1129794009932 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1129794009933 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794009934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794009935 active site 1129794009936 phosphorylation site [posttranslational modification] 1129794009937 intermolecular recognition site; other site 1129794009938 dimerization interface [polypeptide binding]; other site 1129794009939 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1129794009940 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1129794009941 active site 1129794009942 tetramer interface [polypeptide binding]; other site 1129794009943 Mg2+/Mn2+ binding site [ion binding]; other site 1129794009944 isocitrate lyase; Region: PLN02892 1129794009945 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794009946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794009947 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1129794009948 substrate binding pocket [chemical binding]; other site 1129794009949 dimerization interface [polypeptide binding]; other site 1129794009950 malate synthase G; Provisional; Region: PRK02999 1129794009951 active site 1129794009952 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 1129794009953 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1129794009954 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1129794009955 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1129794009956 putative NAD(P) binding site [chemical binding]; other site 1129794009957 active site 1129794009958 putative substrate binding site [chemical binding]; other site 1129794009959 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1129794009960 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1129794009961 putative active site [active] 1129794009962 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1129794009963 nucleophile elbow; other site 1129794009964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1129794009965 hypothetical protein; Validated; Region: PRK08223 1129794009966 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1129794009967 ATP binding site [chemical binding]; other site 1129794009968 substrate interface [chemical binding]; other site 1129794009969 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1129794009970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794009971 binding surface 1129794009972 TPR motif; other site 1129794009973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794009974 binding surface 1129794009975 TPR motif; other site 1129794009976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794009977 binding surface 1129794009978 TPR motif; other site 1129794009979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794009980 TPR motif; other site 1129794009981 binding surface 1129794009982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794009983 binding surface 1129794009984 TPR motif; other site 1129794009985 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1129794009986 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1129794009987 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1129794009988 active site 1129794009989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794009990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794009991 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1129794009992 putative ADP-binding pocket [chemical binding]; other site 1129794009993 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1129794009994 putative active site [active] 1129794009995 putative catalytic site [active] 1129794009996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1129794009997 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1129794009998 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1129794009999 active site 1129794010000 dimer interface [polypeptide binding]; other site 1129794010001 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1129794010002 Ligand Binding Site [chemical binding]; other site 1129794010003 Molecular Tunnel; other site 1129794010004 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1129794010005 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1129794010006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794010007 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1129794010008 putative ADP-binding pocket [chemical binding]; other site 1129794010009 O-Antigen ligase; Region: Wzy_C; pfam04932 1129794010010 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1129794010011 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1129794010012 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1129794010013 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1129794010014 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1129794010015 active site 1129794010016 oxyanion hole [active] 1129794010017 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1129794010018 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1129794010019 active site 1129794010020 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1129794010021 active site 1129794010022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794010023 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1129794010024 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1129794010025 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1129794010026 Transposase; Region: HTH_Tnp_1; pfam01527 1129794010027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794010028 Integrase core domain; Region: rve; pfam00665 1129794010029 Integrase core domain; Region: rve_3; cl15866 1129794010030 colanic acid exporter; Provisional; Region: PRK10459 1129794010031 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1129794010032 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1129794010033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794010034 active site 1129794010035 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1129794010036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1129794010037 active site 1129794010038 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1129794010039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1129794010040 active site 1129794010041 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1129794010042 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1129794010043 active site 1129794010044 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794010045 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1129794010046 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1129794010047 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1129794010048 Ligand binding site; other site 1129794010049 Putative Catalytic site; other site 1129794010050 DXD motif; other site 1129794010051 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1129794010052 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1129794010053 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1129794010054 trimer interface [polypeptide binding]; other site 1129794010055 active site 1129794010056 substrate binding site [chemical binding]; other site 1129794010057 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1129794010058 CoA binding site [chemical binding]; other site 1129794010059 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1129794010060 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794010061 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1129794010062 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1129794010063 exosortase A; Region: exosortase_1; TIGR03109 1129794010064 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1129794010065 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 1129794010066 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 1129794010067 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 1129794010068 putative active site [active] 1129794010069 putative catalytic site [active] 1129794010070 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 1129794010071 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1129794010072 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1129794010073 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1129794010074 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1129794010075 Chain length determinant protein; Region: Wzz; pfam02706 1129794010076 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1129794010077 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1129794010078 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1129794010079 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 1129794010080 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794010081 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794010082 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1129794010083 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1129794010084 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1129794010085 hypothetical protein; Validated; Region: PRK00228 1129794010086 glutathione synthetase; Provisional; Region: PRK05246 1129794010087 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1129794010088 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1129794010089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1129794010090 binding surface 1129794010091 TPR motif; other site 1129794010092 LytTr DNA-binding domain; Region: LytTR; smart00850 1129794010093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010094 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794010095 active site 1129794010096 phosphorylation site [posttranslational modification] 1129794010097 intermolecular recognition site; other site 1129794010098 dimerization interface [polypeptide binding]; other site 1129794010099 LytTr DNA-binding domain; Region: LytTR; smart00850 1129794010100 Histidine kinase; Region: His_kinase; pfam06580 1129794010101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1129794010102 LytTr DNA-binding domain; Region: LytTR; smart00850 1129794010103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1129794010104 active site 1129794010105 dimerization interface [polypeptide binding]; other site 1129794010106 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794010107 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1129794010108 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 1129794010109 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1129794010110 Calx-beta domain; Region: Calx-beta; cl02522 1129794010111 Calx-beta domain; Region: Calx-beta; cl02522 1129794010112 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1129794010113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1129794010114 PEP-CTERM motif; Region: VPEP; pfam07589 1129794010115 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 1129794010116 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1129794010117 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1129794010118 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 1129794010119 ligand binding site [chemical binding]; other site 1129794010120 coregulator recognition site; other site 1129794010121 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1129794010122 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1129794010123 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1129794010124 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1129794010125 Sel1-like repeats; Region: SEL1; smart00671 1129794010126 Sel1-like repeats; Region: SEL1; smart00671 1129794010127 Sel1-like repeats; Region: SEL1; smart00671 1129794010128 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1129794010129 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794010130 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1129794010131 catalytic residue [active] 1129794010132 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 1129794010133 Na binding site [ion binding]; other site 1129794010134 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1129794010135 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1129794010136 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1129794010137 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794010138 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794010139 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1129794010140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1129794010141 DNA-binding site [nucleotide binding]; DNA binding site 1129794010142 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1129794010143 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1129794010144 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1129794010145 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1129794010146 active site 1129794010147 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1129794010148 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1129794010149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794010150 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1129794010151 dimerization interface [polypeptide binding]; other site 1129794010152 substrate binding pocket [chemical binding]; other site 1129794010153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794010154 TPR motif; other site 1129794010155 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1129794010156 binding surface 1129794010157 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1129794010158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794010159 binding surface 1129794010160 TPR motif; other site 1129794010161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794010162 binding surface 1129794010163 TPR motif; other site 1129794010164 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1129794010165 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1129794010166 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794010167 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794010168 short chain dehydrogenase; Provisional; Region: PRK12829 1129794010169 classical (c) SDRs; Region: SDR_c; cd05233 1129794010170 NAD(P) binding site [chemical binding]; other site 1129794010171 active site 1129794010172 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1129794010173 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1129794010174 NAD(P) binding site [chemical binding]; other site 1129794010175 Carboxylesterase family; Region: COesterase; pfam00135 1129794010176 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1129794010177 substrate binding pocket [chemical binding]; other site 1129794010178 catalytic triad [active] 1129794010179 BCCT family transporter; Region: BCCT; cl00569 1129794010180 BCCT family transporter; Region: BCCT; pfam02028 1129794010181 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 1129794010182 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1129794010183 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1129794010184 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1129794010185 catalytic residue [active] 1129794010186 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1129794010187 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1129794010188 putative active site [active] 1129794010189 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1129794010190 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1129794010191 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1129794010192 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1129794010193 putative active site [active] 1129794010194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 1129794010195 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1129794010196 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1129794010197 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1129794010198 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 1129794010199 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1129794010200 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1129794010201 amidase catalytic site [active] 1129794010202 Zn binding residues [ion binding]; other site 1129794010203 substrate binding site [chemical binding]; other site 1129794010204 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1129794010205 Beta-lactamase; Region: Beta-lactamase; cl17358 1129794010206 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794010207 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794010208 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794010209 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1129794010210 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1129794010211 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1129794010212 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1129794010213 NlpC/P60 family; Region: NLPC_P60; cl17555 1129794010214 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1129794010215 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1129794010216 active site 1129794010217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1129794010218 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1129794010219 D-lactate dehydrogenase; Provisional; Region: PRK11183 1129794010220 FAD binding domain; Region: FAD_binding_4; pfam01565 1129794010221 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1129794010222 DNA ligase; Provisional; Region: PRK09125 1129794010223 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 1129794010224 DNA binding site [nucleotide binding] 1129794010225 active site 1129794010226 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 1129794010227 DNA binding site [nucleotide binding] 1129794010228 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1129794010229 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1129794010230 ligand binding site [chemical binding]; other site 1129794010231 flexible hinge region; other site 1129794010232 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1129794010233 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1129794010234 nucleotide binding site [chemical binding]; other site 1129794010235 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1129794010236 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1129794010237 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 1129794010238 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1129794010239 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 1129794010240 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 1129794010241 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794010242 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 1129794010243 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1129794010244 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794010245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010246 active site 1129794010247 phosphorylation site [posttranslational modification] 1129794010248 intermolecular recognition site; other site 1129794010249 dimerization interface [polypeptide binding]; other site 1129794010250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794010251 ATP binding site [chemical binding]; other site 1129794010252 Mg2+ binding site [ion binding]; other site 1129794010253 G-X-G motif; other site 1129794010254 Histidine kinase; Region: HisKA_2; pfam07568 1129794010255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794010256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794010257 dimer interface [polypeptide binding]; other site 1129794010258 phosphorylation site [posttranslational modification] 1129794010259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794010260 ATP binding site [chemical binding]; other site 1129794010261 Mg2+ binding site [ion binding]; other site 1129794010262 G-X-G motif; other site 1129794010263 Heme NO binding; Region: HNOB; pfam07700 1129794010264 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1129794010265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010266 active site 1129794010267 phosphorylation site [posttranslational modification] 1129794010268 intermolecular recognition site; other site 1129794010269 dimerization interface [polypeptide binding]; other site 1129794010270 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794010271 Zn2+ binding site [ion binding]; other site 1129794010272 Mg2+ binding site [ion binding]; other site 1129794010273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010274 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794010275 active site 1129794010276 phosphorylation site [posttranslational modification] 1129794010277 intermolecular recognition site; other site 1129794010278 dimerization interface [polypeptide binding]; other site 1129794010279 CHASE domain; Region: CHASE; pfam03924 1129794010280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010281 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1129794010282 putative active site [active] 1129794010283 heme pocket [chemical binding]; other site 1129794010284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010285 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1129794010286 putative active site [active] 1129794010287 heme pocket [chemical binding]; other site 1129794010288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010289 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1129794010290 putative active site [active] 1129794010291 heme pocket [chemical binding]; other site 1129794010292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010293 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1129794010294 putative active site [active] 1129794010295 heme pocket [chemical binding]; other site 1129794010296 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1129794010297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010298 putative active site [active] 1129794010299 heme pocket [chemical binding]; other site 1129794010300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794010301 dimer interface [polypeptide binding]; other site 1129794010302 phosphorylation site [posttranslational modification] 1129794010303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794010304 ATP binding site [chemical binding]; other site 1129794010305 Mg2+ binding site [ion binding]; other site 1129794010306 G-X-G motif; other site 1129794010307 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1129794010308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794010309 ATP binding site [chemical binding]; other site 1129794010310 Mg2+ binding site [ion binding]; other site 1129794010311 G-X-G motif; other site 1129794010312 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1129794010313 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1129794010314 dimer interface [polypeptide binding]; other site 1129794010315 active site 1129794010316 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1129794010317 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1129794010318 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1129794010319 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1129794010320 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1129794010321 active site 1129794010322 dimer interface [polypeptide binding]; other site 1129794010323 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1129794010324 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1129794010325 dimer interface [polypeptide binding]; other site 1129794010326 active site 1129794010327 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1129794010328 dimer interface [polypeptide binding]; other site 1129794010329 active site 1129794010330 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1129794010331 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1129794010332 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1129794010333 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794010334 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794010335 MarR family; Region: MarR_2; pfam12802 1129794010336 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1129794010337 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1129794010338 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1129794010339 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1129794010340 conserved cys residue [active] 1129794010341 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1129794010342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794010343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794010344 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1129794010345 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1129794010346 active site 1129794010347 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1129794010348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794010349 NAD(P) binding site [chemical binding]; other site 1129794010350 active site 1129794010351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794010352 substrate binding site [chemical binding]; other site 1129794010353 oxyanion hole (OAH) forming residues; other site 1129794010354 trimer interface [polypeptide binding]; other site 1129794010355 Domain of unknown function; Region: DUF331; pfam03889 1129794010356 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1129794010357 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1129794010358 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1129794010359 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1129794010360 putative di-iron ligands [ion binding]; other site 1129794010361 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1129794010362 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794010363 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794010364 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794010365 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1129794010366 CoenzymeA binding site [chemical binding]; other site 1129794010367 subunit interaction site [polypeptide binding]; other site 1129794010368 PHB binding site; other site 1129794010369 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1129794010370 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1129794010371 active site 1129794010372 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1129794010373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794010374 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1129794010375 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794010376 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794010377 N-terminal plug; other site 1129794010378 ligand-binding site [chemical binding]; other site 1129794010379 xanthine permease; Region: pbuX; TIGR03173 1129794010380 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1129794010381 nucleoside/Zn binding site; other site 1129794010382 dimer interface [polypeptide binding]; other site 1129794010383 catalytic motif [active] 1129794010384 D-galactonate transporter; Region: 2A0114; TIGR00893 1129794010385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794010386 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1129794010387 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1129794010388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794010389 ATP binding site [chemical binding]; other site 1129794010390 putative Mg++ binding site [ion binding]; other site 1129794010391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794010392 nucleotide binding region [chemical binding]; other site 1129794010393 ATP-binding site [chemical binding]; other site 1129794010394 Double zinc ribbon; Region: DZR; pfam12773 1129794010395 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 1129794010396 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1129794010397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010398 putative active site [active] 1129794010399 heme pocket [chemical binding]; other site 1129794010400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794010401 dimer interface [polypeptide binding]; other site 1129794010402 phosphorylation site [posttranslational modification] 1129794010403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794010404 ATP binding site [chemical binding]; other site 1129794010405 Mg2+ binding site [ion binding]; other site 1129794010406 G-X-G motif; other site 1129794010407 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1129794010408 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1129794010409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794010410 active site 1129794010411 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1129794010412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794010413 short chain dehydrogenase; Provisional; Region: PRK06181 1129794010414 NAD(P) binding site [chemical binding]; other site 1129794010415 active site 1129794010416 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1129794010417 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1129794010418 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1129794010419 nucleophilic elbow; other site 1129794010420 catalytic triad; other site 1129794010421 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1129794010422 metal binding site [ion binding]; metal-binding site 1129794010423 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1129794010424 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1129794010425 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1129794010426 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1129794010427 ligand binding site [chemical binding]; other site 1129794010428 flexible hinge region; other site 1129794010429 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1129794010430 putative switch regulator; other site 1129794010431 non-specific DNA interactions [nucleotide binding]; other site 1129794010432 DNA binding site [nucleotide binding] 1129794010433 sequence specific DNA binding site [nucleotide binding]; other site 1129794010434 putative cAMP binding site [chemical binding]; other site 1129794010435 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794010436 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794010437 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794010438 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1129794010439 MFS/sugar transport protein; Region: MFS_2; pfam13347 1129794010440 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1129794010441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1129794010442 substrate binding pocket [chemical binding]; other site 1129794010443 catalytic triad [active] 1129794010444 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1129794010445 active site 1129794010446 catalytic triad [active] 1129794010447 oxyanion hole [active] 1129794010448 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794010449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794010450 short chain dehydrogenase; Provisional; Region: PRK12828 1129794010451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794010452 NAD(P) binding site [chemical binding]; other site 1129794010453 active site 1129794010454 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1129794010455 putative active site [active] 1129794010456 putative catalytic site [active] 1129794010457 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1129794010458 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794010459 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1129794010460 acyl-activating enzyme (AAE) consensus motif; other site 1129794010461 putative AMP binding site [chemical binding]; other site 1129794010462 putative active site [active] 1129794010463 putative CoA binding site [chemical binding]; other site 1129794010464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794010465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794010466 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794010467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794010468 Protein of unknown function (DUF2960); Region: DUF2960; pfam11173 1129794010469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794010470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794010471 dimer interface [polypeptide binding]; other site 1129794010472 phosphorylation site [posttranslational modification] 1129794010473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794010474 ATP binding site [chemical binding]; other site 1129794010475 Mg2+ binding site [ion binding]; other site 1129794010476 G-X-G motif; other site 1129794010477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794010478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010479 active site 1129794010480 phosphorylation site [posttranslational modification] 1129794010481 intermolecular recognition site; other site 1129794010482 dimerization interface [polypeptide binding]; other site 1129794010483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794010484 DNA binding site [nucleotide binding] 1129794010485 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794010486 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1129794010487 MltA-interacting protein MipA; Region: MipA; cl01504 1129794010488 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794010489 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1129794010490 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1129794010491 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794010492 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794010493 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1129794010494 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1129794010495 catalytic loop [active] 1129794010496 iron binding site [ion binding]; other site 1129794010497 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1129794010498 glycine dehydrogenase; Provisional; Region: PRK05367 1129794010499 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1129794010500 tetramer interface [polypeptide binding]; other site 1129794010501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794010502 catalytic residue [active] 1129794010503 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1129794010504 tetramer interface [polypeptide binding]; other site 1129794010505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794010506 catalytic residue [active] 1129794010507 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1129794010508 lipoyl attachment site [posttranslational modification]; other site 1129794010509 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1129794010510 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1129794010511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794010512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794010513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794010514 dimerization interface [polypeptide binding]; other site 1129794010515 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1129794010516 Haemolysin-III related; Region: HlyIII; cl03831 1129794010517 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1129794010518 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1129794010519 GIY-YIG motif/motif A; other site 1129794010520 putative active site [active] 1129794010521 putative metal binding site [ion binding]; other site 1129794010522 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1129794010523 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1129794010524 metal binding triad; other site 1129794010525 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1129794010526 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1129794010527 metal binding triad; other site 1129794010528 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1129794010529 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1129794010530 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1129794010531 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1129794010532 putative acyl-acceptor binding pocket; other site 1129794010533 PAS domain S-box; Region: sensory_box; TIGR00229 1129794010534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010535 putative active site [active] 1129794010536 heme pocket [chemical binding]; other site 1129794010537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010538 PAS fold; Region: PAS_3; pfam08447 1129794010539 putative active site [active] 1129794010540 heme pocket [chemical binding]; other site 1129794010541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794010542 PAS domain; Region: PAS_9; pfam13426 1129794010543 putative active site [active] 1129794010544 heme pocket [chemical binding]; other site 1129794010545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794010546 dimer interface [polypeptide binding]; other site 1129794010547 phosphorylation site [posttranslational modification] 1129794010548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794010549 ATP binding site [chemical binding]; other site 1129794010550 Mg2+ binding site [ion binding]; other site 1129794010551 G-X-G motif; other site 1129794010552 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794010553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010554 active site 1129794010555 phosphorylation site [posttranslational modification] 1129794010556 intermolecular recognition site; other site 1129794010557 dimerization interface [polypeptide binding]; other site 1129794010558 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794010559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010560 active site 1129794010561 phosphorylation site [posttranslational modification] 1129794010562 intermolecular recognition site; other site 1129794010563 dimerization interface [polypeptide binding]; other site 1129794010564 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 1129794010565 Protein of unknown function (DUF3081); Region: DUF3081; pfam11280 1129794010566 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794010567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794010568 metal binding site [ion binding]; metal-binding site 1129794010569 active site 1129794010570 I-site; other site 1129794010571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794010572 thymidine kinase; Provisional; Region: PRK04296 1129794010573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1129794010574 ATP binding site [chemical binding]; other site 1129794010575 Walker B motif; other site 1129794010576 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794010577 Protein of unknown function (DUF3718); Region: DUF3718; pfam12514 1129794010578 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1129794010579 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1129794010580 putative valine binding site [chemical binding]; other site 1129794010581 dimer interface [polypeptide binding]; other site 1129794010582 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1129794010583 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1129794010584 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1129794010585 PYR/PP interface [polypeptide binding]; other site 1129794010586 dimer interface [polypeptide binding]; other site 1129794010587 TPP binding site [chemical binding]; other site 1129794010588 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1129794010589 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1129794010590 TPP-binding site [chemical binding]; other site 1129794010591 dimer interface [polypeptide binding]; other site 1129794010592 Protein of unknown function, DUF; Region: DUF413; cl10479 1129794010593 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794010594 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794010595 N-terminal plug; other site 1129794010596 ligand-binding site [chemical binding]; other site 1129794010597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794010598 TPR repeat; Region: TPR_11; pfam13414 1129794010599 binding surface 1129794010600 TPR motif; other site 1129794010601 TPR repeat; Region: TPR_11; pfam13414 1129794010602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794010603 TPR motif; other site 1129794010604 binding surface 1129794010605 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1129794010606 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1129794010607 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1129794010608 catalytic site [active] 1129794010609 putative active site [active] 1129794010610 putative substrate binding site [chemical binding]; other site 1129794010611 dimer interface [polypeptide binding]; other site 1129794010612 GTPase RsgA; Reviewed; Region: PRK12288 1129794010613 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1129794010614 RNA binding site [nucleotide binding]; other site 1129794010615 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1129794010616 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1129794010617 GTP/Mg2+ binding site [chemical binding]; other site 1129794010618 G4 box; other site 1129794010619 G5 box; other site 1129794010620 G1 box; other site 1129794010621 Switch I region; other site 1129794010622 G2 box; other site 1129794010623 G3 box; other site 1129794010624 Switch II region; other site 1129794010625 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1129794010626 EamA-like transporter family; Region: EamA; pfam00892 1129794010627 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1129794010628 EamA-like transporter family; Region: EamA; pfam00892 1129794010629 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1129794010630 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1129794010631 active site 1129794010632 catalytic site [active] 1129794010633 MerC mercury resistance protein; Region: MerC; pfam03203 1129794010634 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1129794010635 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1129794010636 NodB motif; other site 1129794010637 putative active site [active] 1129794010638 putative catalytic site [active] 1129794010639 Zn binding site [ion binding]; other site 1129794010640 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1129794010641 Peptidase family M23; Region: Peptidase_M23; pfam01551 1129794010642 phosphoglyceromutase; Provisional; Region: PRK05434 1129794010643 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1129794010644 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1129794010645 active site residue [active] 1129794010646 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1129794010647 GSH binding site [chemical binding]; other site 1129794010648 catalytic residues [active] 1129794010649 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1129794010650 SecA binding site; other site 1129794010651 Preprotein binding site; other site 1129794010652 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1129794010653 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1129794010654 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1129794010655 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1129794010656 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1129794010657 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1129794010658 alphaNTD homodimer interface [polypeptide binding]; other site 1129794010659 alphaNTD - beta interaction site [polypeptide binding]; other site 1129794010660 alphaNTD - beta' interaction site [polypeptide binding]; other site 1129794010661 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1129794010662 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1129794010663 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1129794010664 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1129794010665 RNA binding surface [nucleotide binding]; other site 1129794010666 30S ribosomal protein S11; Validated; Region: PRK05309 1129794010667 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1129794010668 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1129794010669 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1129794010670 SecY translocase; Region: SecY; pfam00344 1129794010671 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1129794010672 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1129794010673 23S rRNA binding site [nucleotide binding]; other site 1129794010674 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1129794010675 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1129794010676 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1129794010677 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1129794010678 5S rRNA interface [nucleotide binding]; other site 1129794010679 23S rRNA interface [nucleotide binding]; other site 1129794010680 L5 interface [polypeptide binding]; other site 1129794010681 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1129794010682 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1129794010683 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1129794010684 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1129794010685 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1129794010686 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1129794010687 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1129794010688 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1129794010689 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1129794010690 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1129794010691 RNA binding site [nucleotide binding]; other site 1129794010692 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1129794010693 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1129794010694 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 1129794010695 acyl-activating enzyme (AAE) consensus motif; other site 1129794010696 putative AMP binding site [chemical binding]; other site 1129794010697 putative active site [active] 1129794010698 putative CoA binding site [chemical binding]; other site 1129794010699 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1129794010700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794010701 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1129794010702 dimerization interface [polypeptide binding]; other site 1129794010703 substrate binding pocket [chemical binding]; other site 1129794010704 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1129794010705 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1129794010706 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1129794010707 exoribonuclease R; Provisional; Region: PRK11642 1129794010708 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1129794010709 RNB domain; Region: RNB; pfam00773 1129794010710 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1129794010711 RNA binding site [nucleotide binding]; other site 1129794010712 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1129794010713 Sel1 repeat; Region: Sel1; cl02723 1129794010714 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1129794010715 FMN reductase; Validated; Region: fre; PRK08051 1129794010716 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1129794010717 FAD binding pocket [chemical binding]; other site 1129794010718 FAD binding motif [chemical binding]; other site 1129794010719 phosphate binding motif [ion binding]; other site 1129794010720 beta-alpha-beta structure motif; other site 1129794010721 NAD binding pocket [chemical binding]; other site 1129794010722 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1129794010723 lysophospholipase L2; Provisional; Region: PRK10749 1129794010724 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1129794010725 FOG: CBS domain [General function prediction only]; Region: COG0517 1129794010726 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_24; cd04637 1129794010727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794010728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1129794010729 dimerization interface [polypeptide binding]; other site 1129794010730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794010731 dimer interface [polypeptide binding]; other site 1129794010732 phosphorylation site [posttranslational modification] 1129794010733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794010734 ATP binding site [chemical binding]; other site 1129794010735 Mg2+ binding site [ion binding]; other site 1129794010736 G-X-G motif; other site 1129794010737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794010738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010739 active site 1129794010740 phosphorylation site [posttranslational modification] 1129794010741 intermolecular recognition site; other site 1129794010742 dimerization interface [polypeptide binding]; other site 1129794010743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794010744 DNA binding site [nucleotide binding] 1129794010745 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1129794010746 dimer interface [polypeptide binding]; other site 1129794010747 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1129794010748 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1129794010749 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1129794010750 active site 1129794010751 dimer interfaces [polypeptide binding]; other site 1129794010752 catalytic residues [active] 1129794010753 acetylornithine deacetylase; Provisional; Region: PRK05111 1129794010754 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1129794010755 metal binding site [ion binding]; metal-binding site 1129794010756 putative dimer interface [polypeptide binding]; other site 1129794010757 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1129794010758 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1129794010759 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1129794010760 nucleotide binding site [chemical binding]; other site 1129794010761 substrate binding site [chemical binding]; other site 1129794010762 ornithine carbamoyltransferase; Provisional; Region: PRK14805 1129794010763 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1129794010764 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1129794010765 argininosuccinate synthase; Provisional; Region: PRK13820 1129794010766 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1129794010767 ANP binding site [chemical binding]; other site 1129794010768 Substrate Binding Site II [chemical binding]; other site 1129794010769 Substrate Binding Site I [chemical binding]; other site 1129794010770 argininosuccinate lyase; Provisional; Region: PRK04833 1129794010771 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1129794010772 active sites [active] 1129794010773 tetramer interface [polypeptide binding]; other site 1129794010774 N-acetylglutamate synthase; Validated; Region: PRK05279 1129794010775 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1129794010776 putative feedback inhibition sensing region; other site 1129794010777 putative nucleotide binding site [chemical binding]; other site 1129794010778 putative substrate binding site [chemical binding]; other site 1129794010779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794010780 Coenzyme A binding pocket [chemical binding]; other site 1129794010781 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1129794010782 active site 1129794010783 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1129794010784 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1129794010785 active site 1129794010786 intersubunit interface [polypeptide binding]; other site 1129794010787 catalytic residue [active] 1129794010788 glucokinase; Provisional; Region: glk; PRK00292 1129794010789 glucokinase, proteobacterial type; Region: glk; TIGR00749 1129794010790 Dehydratase family; Region: ILVD_EDD; cl00340 1129794010791 Dehydratase family; Region: ILVD_EDD; cl00340 1129794010792 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1129794010793 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1129794010794 putative active site [active] 1129794010795 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1129794010796 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1129794010797 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1129794010798 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1129794010799 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1129794010800 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1129794010801 putative active site [active] 1129794010802 pyruvate kinase; Provisional; Region: PRK05826 1129794010803 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1129794010804 domain interfaces; other site 1129794010805 active site 1129794010806 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1129794010807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794010808 NAD(P) binding site [chemical binding]; other site 1129794010809 active site 1129794010810 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1129794010811 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1129794010812 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1129794010813 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1129794010814 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1129794010815 catalytic site [active] 1129794010816 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1129794010817 ApbE family; Region: ApbE; pfam02424 1129794010818 Predicted methyltransferases [General function prediction only]; Region: COG0313 1129794010819 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1129794010820 putative SAM binding site [chemical binding]; other site 1129794010821 putative homodimer interface [polypeptide binding]; other site 1129794010822 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1129794010823 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1129794010824 putative ligand binding site [chemical binding]; other site 1129794010825 hypothetical protein; Reviewed; Region: PRK12497 1129794010826 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1129794010827 dimer interface [polypeptide binding]; other site 1129794010828 active site 1129794010829 outer membrane lipoprotein; Provisional; Region: PRK11023 1129794010830 BON domain; Region: BON; pfam04972 1129794010831 BON domain; Region: BON; pfam04972 1129794010832 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1129794010833 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1129794010834 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1129794010835 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1129794010836 dimer interface [polypeptide binding]; other site 1129794010837 N-terminal domain interface [polypeptide binding]; other site 1129794010838 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1129794010839 cytochrome b; Provisional; Region: CYTB; MTH00145 1129794010840 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1129794010841 Qi binding site; other site 1129794010842 intrachain domain interface; other site 1129794010843 interchain domain interface [polypeptide binding]; other site 1129794010844 heme bH binding site [chemical binding]; other site 1129794010845 heme bL binding site [chemical binding]; other site 1129794010846 Qo binding site; other site 1129794010847 interchain domain interface [polypeptide binding]; other site 1129794010848 intrachain domain interface; other site 1129794010849 Qi binding site; other site 1129794010850 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1129794010851 Qo binding site; other site 1129794010852 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1129794010853 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1129794010854 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1129794010855 [2Fe-2S] cluster binding site [ion binding]; other site 1129794010856 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1129794010857 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1129794010858 23S rRNA interface [nucleotide binding]; other site 1129794010859 L3 interface [polypeptide binding]; other site 1129794010860 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1129794010861 Peptidase family M23; Region: Peptidase_M23; pfam01551 1129794010862 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1129794010863 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1129794010864 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 1129794010865 Protein of unknown function (DUF1414); Region: DUF1414; cl01175 1129794010866 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1129794010867 Imelysin; Region: Peptidase_M75; cl09159 1129794010868 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1129794010869 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1129794010870 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1129794010871 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1129794010872 Imelysin; Region: Peptidase_M75; pfam09375 1129794010873 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1129794010874 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794010875 N-terminal plug; other site 1129794010876 ligand-binding site [chemical binding]; other site 1129794010877 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 1129794010878 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1129794010879 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1129794010880 Class II fumarases; Region: Fumarase_classII; cd01362 1129794010881 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1129794010882 active site 1129794010883 tetramer interface [polypeptide binding]; other site 1129794010884 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1129794010885 Catalytic site [active] 1129794010886 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 1129794010887 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1129794010888 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794010889 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794010890 N-terminal plug; other site 1129794010891 ligand-binding site [chemical binding]; other site 1129794010892 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794010893 Fe2+ transport protein; Region: Iron_transport; cl01377 1129794010894 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1129794010895 metal binding site 2 [ion binding]; metal-binding site 1129794010896 putative DNA binding helix; other site 1129794010897 metal binding site 1 [ion binding]; metal-binding site 1129794010898 dimer interface [polypeptide binding]; other site 1129794010899 structural Zn2+ binding site [ion binding]; other site 1129794010900 Imelysin; Region: Peptidase_M75; pfam09375 1129794010901 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1129794010902 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794010903 N-terminal plug; other site 1129794010904 ligand-binding site [chemical binding]; other site 1129794010905 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1129794010906 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1129794010907 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1129794010908 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794010909 N-terminal plug; other site 1129794010910 ligand-binding site [chemical binding]; other site 1129794010911 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1129794010912 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1129794010913 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1129794010914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794010915 S-adenosylmethionine binding site [chemical binding]; other site 1129794010916 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 1129794010917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1129794010918 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1129794010919 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1129794010920 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1129794010921 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794010922 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1129794010923 dimerization interface [polypeptide binding]; other site 1129794010924 Predicted membrane protein [Function unknown]; Region: COG2259 1129794010925 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1129794010926 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1129794010927 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1129794010928 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1129794010929 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1129794010930 putative dimer interface [polypeptide binding]; other site 1129794010931 N-terminal domain interface [polypeptide binding]; other site 1129794010932 putative substrate binding pocket (H-site) [chemical binding]; other site 1129794010933 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1129794010934 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1129794010935 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1129794010936 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1129794010937 FMN binding site [chemical binding]; other site 1129794010938 active site 1129794010939 substrate binding site [chemical binding]; other site 1129794010940 catalytic residue [active] 1129794010941 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1129794010942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794010943 NAD(P) binding site [chemical binding]; other site 1129794010944 active site 1129794010945 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1129794010946 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1129794010947 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1129794010948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794010949 substrate binding site [chemical binding]; other site 1129794010950 oxyanion hole (OAH) forming residues; other site 1129794010951 trimer interface [polypeptide binding]; other site 1129794010952 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1129794010953 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1129794010954 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794010955 active site 1129794010956 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1129794010957 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1129794010958 tetrameric interface [polypeptide binding]; other site 1129794010959 NAD binding site [chemical binding]; other site 1129794010960 catalytic residues [active] 1129794010961 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794010962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794010963 active site 1129794010964 phosphorylation site [posttranslational modification] 1129794010965 intermolecular recognition site; other site 1129794010966 dimerization interface [polypeptide binding]; other site 1129794010967 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794010968 Predicted membrane protein [Function unknown]; Region: COG3431 1129794010969 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1129794010970 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1129794010971 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1129794010972 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1129794010973 SOUL heme-binding protein; Region: SOUL; pfam04832 1129794010974 MltA-interacting protein MipA; Region: MipA; cl01504 1129794010975 MltA-interacting protein MipA; Region: MipA; cl01504 1129794010976 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794010977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1129794010978 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1129794010979 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1129794010980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1129794010981 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1129794010982 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1129794010983 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1129794010984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1129794010985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1129794010986 non-specific DNA binding site [nucleotide binding]; other site 1129794010987 salt bridge; other site 1129794010988 sequence-specific DNA binding site [nucleotide binding]; other site 1129794010989 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1129794010990 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1129794010991 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1129794010992 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1129794010993 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1129794010994 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1129794010995 active site 1129794010996 catalytic residues [active] 1129794010997 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1129794010998 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1129794010999 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1129794011000 active site 1129794011001 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1129794011002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794011003 active site 1129794011004 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1129794011005 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1129794011006 conserved cys residue [active] 1129794011007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794011008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794011009 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1129794011010 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1129794011011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794011012 Walker A motif; other site 1129794011013 ATP binding site [chemical binding]; other site 1129794011014 Walker B motif; other site 1129794011015 arginine finger; other site 1129794011016 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1129794011017 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1129794011018 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1129794011019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1129794011020 cyanophycin synthetase; Provisional; Region: PRK14016 1129794011021 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794011022 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1129794011023 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1129794011024 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1129794011025 proposed catalytic triad [active] 1129794011026 active site nucleophile [active] 1129794011027 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1129794011028 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794011029 active site 1129794011030 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1129794011031 metal binding site [ion binding]; metal-binding site 1129794011032 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1129794011033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1129794011034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1129794011035 active site 1129794011036 catalytic tetrad [active] 1129794011037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794011038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794011039 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1129794011040 putative effector binding pocket; other site 1129794011041 dimerization interface [polypeptide binding]; other site 1129794011042 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1129794011043 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794011044 N-terminal plug; other site 1129794011045 ligand-binding site [chemical binding]; other site 1129794011046 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1129794011047 Isochorismatase family; Region: Isochorismatase; pfam00857 1129794011048 catalytic triad [active] 1129794011049 metal binding site [ion binding]; metal-binding site 1129794011050 conserved cis-peptide bond; other site 1129794011051 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 1129794011052 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1129794011053 active site 1129794011054 Transposase IS200 like; Region: Y1_Tnp; cl00848 1129794011055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1129794011056 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1129794011057 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1129794011058 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1129794011059 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1129794011060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794011061 S-adenosylmethionine binding site [chemical binding]; other site 1129794011062 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794011063 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1129794011064 C-terminal domain interface [polypeptide binding]; other site 1129794011065 GSH binding site (G-site) [chemical binding]; other site 1129794011066 dimer interface [polypeptide binding]; other site 1129794011067 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794011068 N-terminal domain interface [polypeptide binding]; other site 1129794011069 dimer interface [polypeptide binding]; other site 1129794011070 substrate binding pocket (H-site) [chemical binding]; other site 1129794011071 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1129794011072 DNA binding site [nucleotide binding] 1129794011073 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1129794011074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1129794011075 Putative transposase; Region: Y2_Tnp; pfam04986 1129794011076 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1129794011077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1129794011078 PEP-CTERM motif; Region: VPEP; pfam07589 1129794011079 Caspase domain; Region: Peptidase_C14; pfam00656 1129794011080 TIR domain; Region: TIR_2; cl17458 1129794011081 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 1129794011082 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1129794011083 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1129794011084 Walker A/P-loop; other site 1129794011085 ATP binding site [chemical binding]; other site 1129794011086 Q-loop/lid; other site 1129794011087 ABC transporter signature motif; other site 1129794011088 Walker B; other site 1129794011089 D-loop; other site 1129794011090 H-loop/switch region; other site 1129794011091 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1129794011092 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1129794011093 ABC-ATPase subunit interface; other site 1129794011094 dimer interface [polypeptide binding]; other site 1129794011095 putative PBP binding regions; other site 1129794011096 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1129794011097 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1129794011098 intersubunit interface [polypeptide binding]; other site 1129794011099 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1129794011100 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794011101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794011102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1129794011103 dimerization interface [polypeptide binding]; other site 1129794011104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794011105 dimer interface [polypeptide binding]; other site 1129794011106 phosphorylation site [posttranslational modification] 1129794011107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794011108 ATP binding site [chemical binding]; other site 1129794011109 Mg2+ binding site [ion binding]; other site 1129794011110 G-X-G motif; other site 1129794011111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794011112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794011113 active site 1129794011114 phosphorylation site [posttranslational modification] 1129794011115 intermolecular recognition site; other site 1129794011116 dimerization interface [polypeptide binding]; other site 1129794011117 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794011118 DNA binding site [nucleotide binding] 1129794011119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794011120 TPR motif; other site 1129794011121 TPR repeat; Region: TPR_11; pfam13414 1129794011122 binding surface 1129794011123 Transposase IS200 like; Region: Y1_Tnp; cl00848 1129794011124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794011125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794011126 putative substrate translocation pore; other site 1129794011127 endonuclease VIII; Provisional; Region: PRK10445 1129794011128 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1129794011129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794011130 ATP binding site [chemical binding]; other site 1129794011131 putative Mg++ binding site [ion binding]; other site 1129794011132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794011133 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1129794011134 nucleotide binding region [chemical binding]; other site 1129794011135 ATP-binding site [chemical binding]; other site 1129794011136 HSP90 family protein; Provisional; Region: PRK14083 1129794011137 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1129794011138 putative inner membrane protein; Provisional; Region: PRK11099 1129794011139 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 1129794011140 DNA-sulfur modification-associated; Region: DndB; cl17621 1129794011141 DGQHR domain; Region: DGQHR; TIGR03187 1129794011142 DNA-sulfur modification-associated; Region: DndB; cl17621 1129794011143 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1129794011144 putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183 1129794011145 Active Sites [active] 1129794011146 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1129794011147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794011148 Walker A/P-loop; other site 1129794011149 ATP binding site [chemical binding]; other site 1129794011150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794011151 ABC transporter signature motif; other site 1129794011152 Walker B; other site 1129794011153 D-loop; other site 1129794011154 H-loop/switch region; other site 1129794011155 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 1129794011156 Ion channel; Region: Ion_trans_2; pfam07885 1129794011157 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 1129794011158 Domain of unknown function DUF87; Region: DUF87; pfam01935 1129794011159 AAA-like domain; Region: AAA_10; pfam12846 1129794011160 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 1129794011161 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 1129794011162 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1129794011163 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1129794011164 SelR domain; Region: SelR; pfam01641 1129794011165 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1129794011166 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1129794011167 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1129794011168 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1129794011169 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1129794011170 active site 1129794011171 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1129794011172 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1129794011173 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1129794011174 substrate binding pocket [chemical binding]; other site 1129794011175 membrane-bound complex binding site; other site 1129794011176 hinge residues; other site 1129794011177 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1129794011178 aminotransferase; Validated; Region: PRK07337 1129794011179 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1129794011180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794011181 homodimer interface [polypeptide binding]; other site 1129794011182 catalytic residue [active] 1129794011183 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1129794011184 putative FMN binding site [chemical binding]; other site 1129794011185 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1129794011186 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1129794011187 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794011188 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1129794011189 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1129794011190 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1129794011191 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1129794011192 dimer interface [polypeptide binding]; other site 1129794011193 substrate binding site [chemical binding]; other site 1129794011194 ATP binding site [chemical binding]; other site 1129794011195 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1129794011196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794011197 Walker A/P-loop; other site 1129794011198 ATP binding site [chemical binding]; other site 1129794011199 Q-loop/lid; other site 1129794011200 ABC transporter signature motif; other site 1129794011201 Walker B; other site 1129794011202 D-loop; other site 1129794011203 H-loop/switch region; other site 1129794011204 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1129794011205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794011206 dimer interface [polypeptide binding]; other site 1129794011207 conserved gate region; other site 1129794011208 putative PBP binding loops; other site 1129794011209 ABC-ATPase subunit interface; other site 1129794011210 NMT1/THI5 like; Region: NMT1; pfam09084 1129794011211 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1129794011212 Putative transcription activator [Transcription]; Region: TenA; COG0819 1129794011213 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1129794011214 substrate binding site [chemical binding]; other site 1129794011215 multimerization interface [polypeptide binding]; other site 1129794011216 ATP binding site [chemical binding]; other site 1129794011217 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1129794011218 thiamine phosphate binding site [chemical binding]; other site 1129794011219 active site 1129794011220 pyrophosphate binding site [ion binding]; other site 1129794011221 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1129794011222 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1129794011223 Potassium binding sites [ion binding]; other site 1129794011224 Cesium cation binding sites [ion binding]; other site 1129794011225 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1129794011226 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1129794011227 dimerization interface [polypeptide binding]; other site 1129794011228 DPS ferroxidase diiron center [ion binding]; other site 1129794011229 ion pore; other site 1129794011230 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1129794011231 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1129794011232 active site 1129794011233 nucleophile elbow; other site 1129794011234 Lipase (class 2); Region: Lipase_2; pfam01674 1129794011235 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794011236 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1129794011237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794011238 active site 1129794011239 motif I; other site 1129794011240 motif II; other site 1129794011241 quinolinate synthetase; Provisional; Region: PRK09375 1129794011242 TPR repeat; Region: TPR_11; pfam13414 1129794011243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794011244 binding surface 1129794011245 TPR motif; other site 1129794011246 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1129794011247 active site 1129794011248 catalytic motif [active] 1129794011249 Zn binding site [ion binding]; other site 1129794011250 SdiA-regulated; Region: SdiA-regulated; cd09971 1129794011251 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1129794011252 active site 1129794011253 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 1129794011254 ECF sigma factor; Region: Sigma70_ECF; pfam07638 1129794011255 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794011256 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1129794011257 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1129794011258 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1129794011259 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1129794011260 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1129794011261 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1129794011262 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1129794011263 Active site serine [active] 1129794011264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1129794011265 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794011266 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1129794011267 C-terminal domain interface [polypeptide binding]; other site 1129794011268 GSH binding site (G-site) [chemical binding]; other site 1129794011269 dimer interface [polypeptide binding]; other site 1129794011270 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1129794011271 ATP-binding site [chemical binding]; other site 1129794011272 Gluconate-6-phosphate binding site [chemical binding]; other site 1129794011273 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1129794011274 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1129794011275 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1129794011276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1129794011277 DNA binding site [nucleotide binding] 1129794011278 domain linker motif; other site 1129794011279 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1129794011280 putative dimerization interface [polypeptide binding]; other site 1129794011281 putative ligand binding site [chemical binding]; other site 1129794011282 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1129794011283 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1129794011284 Protein of unknown function (DUF962); Region: DUF962; cl01879 1129794011285 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1129794011286 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1129794011287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1129794011288 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1129794011289 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794011290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794011291 catalytic residue [active] 1129794011292 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 1129794011293 putative active site [active] 1129794011294 Zn binding site [ion binding]; other site 1129794011295 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1129794011296 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1129794011297 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794011298 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794011299 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1129794011300 acyl-CoA esterase; Provisional; Region: PRK10673 1129794011301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1129794011302 Autotransporter beta-domain; Region: Autotransporter; cl17461 1129794011303 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1129794011304 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1129794011305 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1129794011306 catalytic residue [active] 1129794011307 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1129794011308 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1129794011309 NAD binding site [chemical binding]; other site 1129794011310 ligand binding site [chemical binding]; other site 1129794011311 catalytic site [active] 1129794011312 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1129794011313 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1129794011314 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1129794011315 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1129794011316 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794011317 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 1129794011318 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794011319 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794011320 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794011321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1129794011322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794011323 homodimer interface [polypeptide binding]; other site 1129794011324 catalytic residue [active] 1129794011325 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1129794011326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794011327 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794011328 active site 1129794011329 phosphorylation site [posttranslational modification] 1129794011330 intermolecular recognition site; other site 1129794011331 dimerization interface [polypeptide binding]; other site 1129794011332 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1129794011333 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1129794011334 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1129794011335 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1129794011336 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1129794011337 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1129794011338 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794011339 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1129794011340 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1129794011341 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1129794011342 active site 1129794011343 catalytic residues [active] 1129794011344 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794011345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794011346 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1129794011347 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1129794011348 Homeodomain-like domain; Region: HTH_32; pfam13565 1129794011349 Integrase core domain; Region: rve; pfam00665 1129794011350 elongation factor Tu; Reviewed; Region: PRK00049 1129794011351 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1129794011352 G1 box; other site 1129794011353 GEF interaction site [polypeptide binding]; other site 1129794011354 GTP/Mg2+ binding site [chemical binding]; other site 1129794011355 Switch I region; other site 1129794011356 G2 box; other site 1129794011357 G3 box; other site 1129794011358 Switch II region; other site 1129794011359 G4 box; other site 1129794011360 G5 box; other site 1129794011361 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1129794011362 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1129794011363 Antibiotic Binding Site [chemical binding]; other site 1129794011364 elongation factor G; Reviewed; Region: PRK00007 1129794011365 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1129794011366 G1 box; other site 1129794011367 putative GEF interaction site [polypeptide binding]; other site 1129794011368 GTP/Mg2+ binding site [chemical binding]; other site 1129794011369 Switch I region; other site 1129794011370 G2 box; other site 1129794011371 G3 box; other site 1129794011372 Switch II region; other site 1129794011373 G4 box; other site 1129794011374 G5 box; other site 1129794011375 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1129794011376 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1129794011377 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1129794011378 30S ribosomal protein S7; Validated; Region: PRK05302 1129794011379 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1129794011380 S17 interaction site [polypeptide binding]; other site 1129794011381 S8 interaction site; other site 1129794011382 16S rRNA interaction site [nucleotide binding]; other site 1129794011383 streptomycin interaction site [chemical binding]; other site 1129794011384 23S rRNA interaction site [nucleotide binding]; other site 1129794011385 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1129794011386 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1129794011387 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1129794011388 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1129794011389 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1129794011390 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1129794011391 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1129794011392 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1129794011393 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1129794011394 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1129794011395 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1129794011396 DNA binding site [nucleotide binding] 1129794011397 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1129794011398 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1129794011399 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1129794011400 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1129794011401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1129794011402 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1129794011403 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1129794011404 RPB3 interaction site [polypeptide binding]; other site 1129794011405 RPB1 interaction site [polypeptide binding]; other site 1129794011406 RPB11 interaction site [polypeptide binding]; other site 1129794011407 RPB10 interaction site [polypeptide binding]; other site 1129794011408 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1129794011409 core dimer interface [polypeptide binding]; other site 1129794011410 peripheral dimer interface [polypeptide binding]; other site 1129794011411 L10 interface [polypeptide binding]; other site 1129794011412 L11 interface [polypeptide binding]; other site 1129794011413 putative EF-Tu interaction site [polypeptide binding]; other site 1129794011414 putative EF-G interaction site [polypeptide binding]; other site 1129794011415 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1129794011416 23S rRNA interface [nucleotide binding]; other site 1129794011417 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1129794011418 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1129794011419 mRNA/rRNA interface [nucleotide binding]; other site 1129794011420 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1129794011421 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1129794011422 23S rRNA interface [nucleotide binding]; other site 1129794011423 L7/L12 interface [polypeptide binding]; other site 1129794011424 putative thiostrepton binding site; other site 1129794011425 L25 interface [polypeptide binding]; other site 1129794011426 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1129794011427 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1129794011428 putative homodimer interface [polypeptide binding]; other site 1129794011429 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1129794011430 heterodimer interface [polypeptide binding]; other site 1129794011431 homodimer interface [polypeptide binding]; other site 1129794011432 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1129794011433 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1129794011434 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1129794011435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1129794011436 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1129794011437 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1129794011438 active site 1129794011439 LysE type translocator; Region: LysE; cl00565 1129794011440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1129794011441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1129794011442 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1129794011443 Walker A/P-loop; other site 1129794011444 ATP binding site [chemical binding]; other site 1129794011445 Q-loop/lid; other site 1129794011446 ABC transporter signature motif; other site 1129794011447 Walker B; other site 1129794011448 D-loop; other site 1129794011449 H-loop/switch region; other site 1129794011450 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1129794011451 MAPEG family; Region: MAPEG; pfam01124 1129794011452 universal stress protein UspE; Provisional; Region: PRK11175 1129794011453 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1129794011454 Ligand Binding Site [chemical binding]; other site 1129794011455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1129794011456 Ligand Binding Site [chemical binding]; other site 1129794011457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1129794011458 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1129794011459 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1129794011460 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1129794011461 ATP binding site [chemical binding]; other site 1129794011462 Mg++ binding site [ion binding]; other site 1129794011463 motif III; other site 1129794011464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794011465 nucleotide binding region [chemical binding]; other site 1129794011466 ATP-binding site [chemical binding]; other site 1129794011467 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1129794011468 putative RNA binding site [nucleotide binding]; other site 1129794011469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1129794011470 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1129794011471 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794011472 trimer interface [polypeptide binding]; other site 1129794011473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1129794011474 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1129794011475 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1129794011476 substrate binding pocket [chemical binding]; other site 1129794011477 membrane-bound complex binding site; other site 1129794011478 hinge residues; other site 1129794011479 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1129794011480 active site 1129794011481 substrate binding pocket [chemical binding]; other site 1129794011482 dimer interface [polypeptide binding]; other site 1129794011483 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1129794011484 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1129794011485 putative acyl-acceptor binding pocket; other site 1129794011486 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1129794011487 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1129794011488 Amidohydrolase; Region: Amidohydro_2; pfam04909 1129794011489 active site 1129794011490 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794011491 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1129794011492 DctM-like transporters; Region: DctM; pfam06808 1129794011493 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1129794011494 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1129794011495 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1129794011496 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1129794011497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1129794011498 Histidine kinase; Region: HisKA_3; pfam07730 1129794011499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794011500 ATP binding site [chemical binding]; other site 1129794011501 Mg2+ binding site [ion binding]; other site 1129794011502 G-X-G motif; other site 1129794011503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1129794011504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794011505 active site 1129794011506 phosphorylation site [posttranslational modification] 1129794011507 intermolecular recognition site; other site 1129794011508 dimerization interface [polypeptide binding]; other site 1129794011509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794011510 DNA binding residues [nucleotide binding] 1129794011511 dimerization interface [polypeptide binding]; other site 1129794011512 MltA-interacting protein MipA; Region: MipA; cl01504 1129794011513 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1129794011514 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1129794011515 active site triad [active] 1129794011516 MltA-interacting protein MipA; Region: MipA; cl01504 1129794011517 Protein of unknown function (DUF3019); Region: DUF3019; pfam11456 1129794011518 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1129794011519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794011520 active site 1129794011521 phosphorylation site [posttranslational modification] 1129794011522 intermolecular recognition site; other site 1129794011523 dimerization interface [polypeptide binding]; other site 1129794011524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794011525 DNA binding site [nucleotide binding] 1129794011526 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1129794011527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1129794011528 dimerization interface [polypeptide binding]; other site 1129794011529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794011530 dimer interface [polypeptide binding]; other site 1129794011531 phosphorylation site [posttranslational modification] 1129794011532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794011533 ATP binding site [chemical binding]; other site 1129794011534 Mg2+ binding site [ion binding]; other site 1129794011535 G-X-G motif; other site 1129794011536 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1129794011537 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1129794011538 PhnA protein; Region: PhnA; pfam03831 1129794011539 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1129794011540 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1129794011541 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794011542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794011543 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1129794011544 xylulokinase; Provisional; Region: PRK15027 1129794011545 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1129794011546 N- and C-terminal domain interface [polypeptide binding]; other site 1129794011547 active site 1129794011548 MgATP binding site [chemical binding]; other site 1129794011549 catalytic site [active] 1129794011550 metal binding site [ion binding]; metal-binding site 1129794011551 xylulose binding site [chemical binding]; other site 1129794011552 homodimer interface [polypeptide binding]; other site 1129794011553 xylose isomerase; Provisional; Region: PRK05474 1129794011554 xylose isomerase; Region: xylose_isom_A; TIGR02630 1129794011555 Transposase; Region: HTH_Tnp_1; pfam01527 1129794011556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794011557 HTH-like domain; Region: HTH_21; pfam13276 1129794011558 Integrase core domain; Region: rve; pfam00665 1129794011559 Integrase core domain; Region: rve_2; pfam13333 1129794011560 Predicted transcriptional regulators [Transcription]; Region: COG1510 1129794011561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1129794011562 putative DNA binding site [nucleotide binding]; other site 1129794011563 putative Zn2+ binding site [ion binding]; other site 1129794011564 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1129794011565 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1129794011566 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1129794011567 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1129794011568 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1129794011569 homotrimer interaction site [polypeptide binding]; other site 1129794011570 putative active site [active] 1129794011571 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 1129794011572 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794011573 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1129794011574 C-terminal domain interface [polypeptide binding]; other site 1129794011575 GSH binding site (G-site) [chemical binding]; other site 1129794011576 dimer interface [polypeptide binding]; other site 1129794011577 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1129794011578 N-terminal domain interface [polypeptide binding]; other site 1129794011579 dimer interface [polypeptide binding]; other site 1129794011580 substrate binding pocket (H-site) [chemical binding]; other site 1129794011581 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1129794011582 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 1129794011583 hypothetical protein; Provisional; Region: PRK11171 1129794011584 Cupin domain; Region: Cupin_2; pfam07883 1129794011585 Cupin domain; Region: Cupin_2; pfam07883 1129794011586 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1129794011587 FCD domain; Region: FCD; pfam07729 1129794011588 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794011589 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794011590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794011591 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1129794011592 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1129794011593 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1129794011594 active site 1129794011595 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1129794011596 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1129794011597 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1129794011598 putative active site [active] 1129794011599 PhoH-like protein; Region: PhoH; pfam02562 1129794011600 ATP-dependent helicase HepA; Validated; Region: PRK04914 1129794011601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794011602 ATP binding site [chemical binding]; other site 1129794011603 putative Mg++ binding site [ion binding]; other site 1129794011604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794011605 nucleotide binding region [chemical binding]; other site 1129794011606 ATP-binding site [chemical binding]; other site 1129794011607 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1129794011608 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1129794011609 active site 1129794011610 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794011611 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1129794011612 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 1129794011613 muropeptide transporter; Validated; Region: ampG; cl17669 1129794011614 muropeptide transporter; Validated; Region: ampG; cl17669 1129794011615 muropeptide transporter; Validated; Region: ampG; cl17669 1129794011616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1129794011617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794011618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794011619 metal binding site [ion binding]; metal-binding site 1129794011620 active site 1129794011621 I-site; other site 1129794011622 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794011623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794011624 active site 1129794011625 phosphorylation site [posttranslational modification] 1129794011626 intermolecular recognition site; other site 1129794011627 dimerization interface [polypeptide binding]; other site 1129794011628 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1129794011629 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1129794011630 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1129794011631 dimerization interface [polypeptide binding]; other site 1129794011632 active site 1129794011633 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1129794011634 GAF domain; Region: GAF; pfam01590 1129794011635 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1129794011636 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1129794011637 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1129794011638 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1129794011639 putative active site [active] 1129794011640 Ap4A binding site [chemical binding]; other site 1129794011641 nudix motif; other site 1129794011642 putative metal binding site [ion binding]; other site 1129794011643 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1129794011644 putative DNA-binding cleft [nucleotide binding]; other site 1129794011645 putative DNA clevage site; other site 1129794011646 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 1129794011647 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1129794011648 NAD(P) binding site [chemical binding]; other site 1129794011649 catalytic residues [active] 1129794011650 acetolactate synthase; Reviewed; Region: PRK08322 1129794011651 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1129794011652 PYR/PP interface [polypeptide binding]; other site 1129794011653 dimer interface [polypeptide binding]; other site 1129794011654 TPP binding site [chemical binding]; other site 1129794011655 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1129794011656 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1129794011657 TPP-binding site [chemical binding]; other site 1129794011658 dimer interface [polypeptide binding]; other site 1129794011659 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1129794011660 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1129794011661 putative active site [active] 1129794011662 putative metal binding residues [ion binding]; other site 1129794011663 signature motif; other site 1129794011664 putative triphosphate binding site [ion binding]; other site 1129794011665 SH3 domain-containing protein; Provisional; Region: PRK10884 1129794011666 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1129794011667 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 1129794011668 Septum formation initiator; Region: DivIC; cl17659 1129794011669 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1129794011670 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1129794011671 substrate binding site; other site 1129794011672 dimer interface; other site 1129794011673 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1129794011674 homotrimer interaction site [polypeptide binding]; other site 1129794011675 zinc binding site [ion binding]; other site 1129794011676 CDP-binding sites; other site 1129794011677 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 1129794011678 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1129794011679 Permutation of conserved domain; other site 1129794011680 active site 1129794011681 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1129794011682 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1129794011683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794011684 S-adenosylmethionine binding site [chemical binding]; other site 1129794011685 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1129794011686 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1129794011687 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1129794011688 Peptidase family M23; Region: Peptidase_M23; pfam01551 1129794011689 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1129794011690 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1129794011691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794011692 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1129794011693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794011694 DNA binding residues [nucleotide binding] 1129794011695 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1129794011696 dimer interface [polypeptide binding]; other site 1129794011697 catalytic triad [active] 1129794011698 peroxidatic and resolving cysteines [active] 1129794011699 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1129794011700 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1129794011701 folate binding site [chemical binding]; other site 1129794011702 NADP+ binding site [chemical binding]; other site 1129794011703 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1129794011704 putative active site [active] 1129794011705 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1129794011706 GTP1/OBG; Region: GTP1_OBG; pfam01018 1129794011707 Obg GTPase; Region: Obg; cd01898 1129794011708 G1 box; other site 1129794011709 GTP/Mg2+ binding site [chemical binding]; other site 1129794011710 Switch I region; other site 1129794011711 G2 box; other site 1129794011712 G3 box; other site 1129794011713 Switch II region; other site 1129794011714 G4 box; other site 1129794011715 G5 box; other site 1129794011716 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1129794011717 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1129794011718 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1129794011719 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1129794011720 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1129794011721 substrate binding pocket [chemical binding]; other site 1129794011722 chain length determination region; other site 1129794011723 substrate-Mg2+ binding site; other site 1129794011724 catalytic residues [active] 1129794011725 aspartate-rich region 1; other site 1129794011726 active site lid residues [active] 1129794011727 aspartate-rich region 2; other site 1129794011728 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1129794011729 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1129794011730 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1129794011731 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1129794011732 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1129794011733 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794011734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794011735 DNA binding residues [nucleotide binding] 1129794011736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1129794011737 MOSC domain; Region: MOSC; pfam03473 1129794011738 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1129794011739 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1129794011740 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1129794011741 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1129794011742 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1129794011743 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1129794011744 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1129794011745 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1129794011746 DNA methylase; Region: N6_N4_Mtase; pfam01555 1129794011747 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1129794011748 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1129794011749 oligomerisation interface [polypeptide binding]; other site 1129794011750 mobile loop; other site 1129794011751 roof hairpin; other site 1129794011752 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1129794011753 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1129794011754 ring oligomerisation interface [polypeptide binding]; other site 1129794011755 ATP/Mg binding site [chemical binding]; other site 1129794011756 stacking interactions; other site 1129794011757 hinge regions; other site 1129794011758 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 1129794011759 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1129794011760 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1129794011761 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1129794011762 Integrase core domain; Region: rve_3; cl15866 1129794011763 Integrase core domain; Region: rve; pfam00665 1129794011764 putative transposase OrfB; Reviewed; Region: PHA02517 1129794011765 Transposase; Region: HTH_Tnp_1; pfam01527 1129794011766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794011767 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1129794011768 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1129794011769 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1129794011770 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1129794011771 Phytase; Region: Phytase; cl17685 1129794011772 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1129794011773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794011774 ATP binding site [chemical binding]; other site 1129794011775 putative Mg++ binding site [ion binding]; other site 1129794011776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794011777 nucleotide binding region [chemical binding]; other site 1129794011778 ATP-binding site [chemical binding]; other site 1129794011779 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1129794011780 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1129794011781 short chain dehydrogenase; Provisional; Region: PRK08267 1129794011782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794011783 NAD(P) binding site [chemical binding]; other site 1129794011784 active site 1129794011785 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1129794011786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1129794011787 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794011788 Helix-turn-helix domain; Region: HTH_18; pfam12833 1129794011789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794011790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794011791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794011792 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1129794011793 dimerization interface [polypeptide binding]; other site 1129794011794 Sulfatase; Region: Sulfatase; cl17466 1129794011795 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1129794011796 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1129794011797 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1129794011798 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1129794011799 active site 1129794011800 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1129794011801 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1129794011802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1129794011803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794011804 DNA binding site [nucleotide binding] 1129794011805 AAA ATPase domain; Region: AAA_16; pfam13191 1129794011806 Domain of unknown function (DUF1888); Region: DUF1888; pfam08985 1129794011807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794011808 PAS domain; Region: PAS_9; pfam13426 1129794011809 putative active site [active] 1129794011810 heme pocket [chemical binding]; other site 1129794011811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794011812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794011813 metal binding site [ion binding]; metal-binding site 1129794011814 active site 1129794011815 I-site; other site 1129794011816 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1129794011817 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794011818 active site 1129794011819 malate dehydrogenase; Provisional; Region: PRK13529 1129794011820 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1129794011821 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1129794011822 NAD(P) binding site [chemical binding]; other site 1129794011823 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1129794011824 Transglycosylase; Region: Transgly; pfam00912 1129794011825 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1129794011826 Competence protein A; Region: Competence_A; pfam11104 1129794011827 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1129794011828 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1129794011829 Pilus assembly protein, PilO; Region: PilO; pfam04350 1129794011830 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 1129794011831 Pilus assembly protein, PilP; Region: PilP; pfam04351 1129794011832 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1129794011833 Secretin and TonB N terminus short domain; Region: STN; smart00965 1129794011834 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1129794011835 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1129794011836 shikimate kinase; Reviewed; Region: aroK; PRK00131 1129794011837 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1129794011838 ADP binding site [chemical binding]; other site 1129794011839 magnesium binding site [ion binding]; other site 1129794011840 putative shikimate binding site; other site 1129794011841 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1129794011842 active site 1129794011843 dimer interface [polypeptide binding]; other site 1129794011844 metal binding site [ion binding]; metal-binding site 1129794011845 cell division protein DamX; Validated; Region: PRK10905 1129794011846 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1129794011847 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1129794011848 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1129794011849 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1129794011850 substrate binding site [chemical binding]; other site 1129794011851 hexamer interface [polypeptide binding]; other site 1129794011852 metal binding site [ion binding]; metal-binding site 1129794011853 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1129794011854 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1129794011855 active site 1129794011856 HIGH motif; other site 1129794011857 dimer interface [polypeptide binding]; other site 1129794011858 KMSKS motif; other site 1129794011859 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1129794011860 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1129794011861 glutamine binding [chemical binding]; other site 1129794011862 catalytic triad [active] 1129794011863 HDOD domain; Region: HDOD; pfam08668 1129794011864 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1129794011865 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1129794011866 inhibitor-cofactor binding pocket; inhibition site 1129794011867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1129794011868 catalytic residue [active] 1129794011869 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1129794011870 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 1129794011871 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1129794011872 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1129794011873 NAD(P) binding site [chemical binding]; other site 1129794011874 catalytic residues [active] 1129794011875 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1129794011876 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1129794011877 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1129794011878 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1129794011879 Cl- selectivity filter; other site 1129794011880 Cl- binding residues [ion binding]; other site 1129794011881 pore gating glutamate residue; other site 1129794011882 dimer interface [polypeptide binding]; other site 1129794011883 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1129794011884 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1129794011885 homodecamer interface [polypeptide binding]; other site 1129794011886 GTP cyclohydrolase I; Provisional; Region: PLN03044 1129794011887 active site 1129794011888 putative catalytic site residues [active] 1129794011889 zinc binding site [ion binding]; other site 1129794011890 GTP-CH-I/GFRP interaction surface; other site 1129794011891 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1129794011892 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1129794011893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794011894 Walker A/P-loop; other site 1129794011895 ATP binding site [chemical binding]; other site 1129794011896 Q-loop/lid; other site 1129794011897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794011898 ABC transporter signature motif; other site 1129794011899 Walker B; other site 1129794011900 D-loop; other site 1129794011901 hypothetical protein; Provisional; Region: PRK12378 1129794011902 Predicted ATPase [General function prediction only]; Region: COG1485 1129794011903 Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123 1129794011904 dimer interface [polypeptide binding]; other site 1129794011905 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1129794011906 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1129794011907 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1129794011908 protein binding site [polypeptide binding]; other site 1129794011909 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1129794011910 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1129794011911 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1129794011912 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1129794011913 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1129794011914 hinge; other site 1129794011915 active site 1129794011916 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1129794011917 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1129794011918 anti sigma factor interaction site; other site 1129794011919 regulatory phosphorylation site [posttranslational modification]; other site 1129794011920 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 1129794011921 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1129794011922 mce related protein; Region: MCE; pfam02470 1129794011923 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1129794011924 Permease; Region: Permease; cl00510 1129794011925 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1129794011926 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1129794011927 Walker A/P-loop; other site 1129794011928 ATP binding site [chemical binding]; other site 1129794011929 Q-loop/lid; other site 1129794011930 ABC transporter signature motif; other site 1129794011931 Walker B; other site 1129794011932 D-loop; other site 1129794011933 H-loop/switch region; other site 1129794011934 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794011935 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794011936 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1129794011937 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1129794011938 putative active site [active] 1129794011939 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1129794011940 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1129794011941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794011942 active site 1129794011943 motif I; other site 1129794011944 motif II; other site 1129794011945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1129794011946 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1129794011947 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1129794011948 OstA-like protein; Region: OstA; pfam03968 1129794011949 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1129794011950 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1129794011951 Walker A/P-loop; other site 1129794011952 ATP binding site [chemical binding]; other site 1129794011953 Q-loop/lid; other site 1129794011954 ABC transporter signature motif; other site 1129794011955 Walker B; other site 1129794011956 D-loop; other site 1129794011957 H-loop/switch region; other site 1129794011958 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1129794011959 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1129794011960 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1129794011961 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1129794011962 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1129794011963 30S subunit binding site; other site 1129794011964 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1129794011965 active site 1129794011966 phosphorylation site [posttranslational modification] 1129794011967 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1129794011968 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1129794011969 dimerization domain swap beta strand [polypeptide binding]; other site 1129794011970 regulatory protein interface [polypeptide binding]; other site 1129794011971 active site 1129794011972 regulatory phosphorylation site [posttranslational modification]; other site 1129794011973 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1129794011974 generic binding surface II; other site 1129794011975 generic binding surface I; other site 1129794011976 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1129794011977 putative active site [active] 1129794011978 putative catalytic site [active] 1129794011979 putative Mg binding site IVb [ion binding]; other site 1129794011980 putative phosphate binding site [ion binding]; other site 1129794011981 putative DNA binding site [nucleotide binding]; other site 1129794011982 putative Mg binding site IVa [ion binding]; other site 1129794011983 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1129794011984 MgtE intracellular N domain; Region: MgtE_N; smart00924 1129794011985 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1129794011986 Divalent cation transporter; Region: MgtE; pfam01769 1129794011987 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1129794011988 EamA-like transporter family; Region: EamA; pfam00892 1129794011989 galactokinase; Provisional; Region: PRK05101 1129794011990 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1129794011991 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1129794011992 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1129794011993 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1129794011994 nucleotide binding site/active site [active] 1129794011995 HIT family signature motif; other site 1129794011996 catalytic residue [active] 1129794011997 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1129794011998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1129794011999 putative active site [active] 1129794012000 heme pocket [chemical binding]; other site 1129794012001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794012002 dimer interface [polypeptide binding]; other site 1129794012003 phosphorylation site [posttranslational modification] 1129794012004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794012005 ATP binding site [chemical binding]; other site 1129794012006 Mg2+ binding site [ion binding]; other site 1129794012007 G-X-G motif; other site 1129794012008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794012009 active site 1129794012010 phosphorylation site [posttranslational modification] 1129794012011 intermolecular recognition site; other site 1129794012012 dimerization interface [polypeptide binding]; other site 1129794012013 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1129794012014 putative binding surface; other site 1129794012015 active site 1129794012016 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1129794012017 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1129794012018 active site 1129794012019 dimer interface [polypeptide binding]; other site 1129794012020 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1129794012021 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1129794012022 active site 1129794012023 FMN binding site [chemical binding]; other site 1129794012024 substrate binding site [chemical binding]; other site 1129794012025 3Fe-4S cluster binding site [ion binding]; other site 1129794012026 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1129794012027 domain interface; other site 1129794012028 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1129794012029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794012030 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1129794012031 putative metal binding site [ion binding]; other site 1129794012032 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 1129794012033 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1129794012034 putative catalytic site [active] 1129794012035 putative phosphate binding site [ion binding]; other site 1129794012036 putative metal binding site [ion binding]; other site 1129794012037 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1129794012038 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794012039 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1129794012040 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1129794012041 ATP-binding site [chemical binding]; other site 1129794012042 Sugar specificity; other site 1129794012043 Pyrimidine base specificity; other site 1129794012044 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1129794012045 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1129794012046 Nucleoside recognition; Region: Gate; pfam07670 1129794012047 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1129794012048 aminocyclopropanecarboxylate oxidase; Region: PLN02403 1129794012049 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1129794012050 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1129794012051 TPR repeat; Region: TPR_11; pfam13414 1129794012052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794012053 binding surface 1129794012054 TPR motif; other site 1129794012055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794012056 binding surface 1129794012057 TPR motif; other site 1129794012058 TPR repeat; Region: TPR_11; pfam13414 1129794012059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794012060 binding surface 1129794012061 TPR motif; other site 1129794012062 TPR repeat; Region: TPR_11; pfam13414 1129794012063 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 1129794012064 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1129794012065 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1129794012066 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1129794012067 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1129794012068 active site residue [active] 1129794012069 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1129794012070 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1129794012071 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1129794012072 active site 1129794012073 HIGH motif; other site 1129794012074 dimer interface [polypeptide binding]; other site 1129794012075 KMSKS motif; other site 1129794012076 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1129794012077 RNA binding surface [nucleotide binding]; other site 1129794012078 putative peptidase; Provisional; Region: PRK11649 1129794012079 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1129794012080 Peptidase family M23; Region: Peptidase_M23; pfam01551 1129794012081 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1129794012082 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1129794012083 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1129794012084 putative DNA binding site [nucleotide binding]; other site 1129794012085 putative Zn2+ binding site [ion binding]; other site 1129794012086 AsnC family; Region: AsnC_trans_reg; pfam01037 1129794012087 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1129794012088 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1129794012089 active site 1129794012090 Zn binding site [ion binding]; other site 1129794012091 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1129794012092 EAL domain; Region: EAL; pfam00563 1129794012093 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1129794012094 EAL domain; Region: EAL; pfam00563 1129794012095 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1129794012096 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1129794012097 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1129794012098 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794012099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794012100 DNA binding residues [nucleotide binding] 1129794012101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1129794012102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794012103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1129794012104 Coenzyme A binding pocket [chemical binding]; other site 1129794012105 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1129794012106 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1129794012107 putative active site [active] 1129794012108 dimerization interface [polypeptide binding]; other site 1129794012109 putative tRNAtyr binding site [nucleotide binding]; other site 1129794012110 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1129794012111 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1129794012112 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 1129794012113 hypothetical protein; Reviewed; Region: PRK01637 1129794012114 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1129794012115 FAD binding site [chemical binding]; other site 1129794012116 transcriptional repressor protein MetJ; Provisional; Region: PRK05264 1129794012117 dimerization interface [polypeptide binding]; other site 1129794012118 DNA binding site [nucleotide binding] 1129794012119 corepressor binding sites; other site 1129794012120 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1129794012121 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1129794012122 putative C-terminal domain interface [polypeptide binding]; other site 1129794012123 putative GSH binding site (G-site) [chemical binding]; other site 1129794012124 putative dimer interface [polypeptide binding]; other site 1129794012125 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1129794012126 putative N-terminal domain interface [polypeptide binding]; other site 1129794012127 putative dimer interface [polypeptide binding]; other site 1129794012128 putative substrate binding pocket (H-site) [chemical binding]; other site 1129794012129 HD domain; Region: HD_3; pfam13023 1129794012130 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1129794012131 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1129794012132 hypothetical protein; Validated; Region: PRK00029 1129794012133 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1129794012134 hypothetical protein; Validated; Region: PRK00029 1129794012135 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1129794012136 PAS domain S-box; Region: sensory_box; TIGR00229 1129794012137 PAS domain; Region: PAS_8; pfam13188 1129794012138 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794012139 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794012140 metal binding site [ion binding]; metal-binding site 1129794012141 active site 1129794012142 I-site; other site 1129794012143 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794012144 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1129794012145 dimerization interface [polypeptide binding]; other site 1129794012146 active site 1129794012147 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1129794012148 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1129794012149 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1129794012150 MULE transposase domain; Region: MULE; pfam10551 1129794012151 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 1129794012152 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1129794012153 malate dehydrogenase; Provisional; Region: PRK05086 1129794012154 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1129794012155 NAD binding site [chemical binding]; other site 1129794012156 dimerization interface [polypeptide binding]; other site 1129794012157 Substrate binding site [chemical binding]; other site 1129794012158 arginine repressor; Provisional; Region: PRK05066 1129794012159 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1129794012160 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1129794012161 Paraquat-inducible protein A; Region: PqiA; pfam04403 1129794012162 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1129794012163 Active site serine [active] 1129794012164 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1129794012165 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1129794012166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1129794012167 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1129794012168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794012169 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1129794012170 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1129794012171 23S rRNA interface [nucleotide binding]; other site 1129794012172 putative translocon interaction site; other site 1129794012173 signal recognition particle (SRP54) interaction site; other site 1129794012174 L23 interface [polypeptide binding]; other site 1129794012175 trigger factor interaction site; other site 1129794012176 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1129794012177 23S rRNA interface [nucleotide binding]; other site 1129794012178 putative antibiotic binding site [chemical binding]; other site 1129794012179 L25 interface [polypeptide binding]; other site 1129794012180 L27 interface [polypeptide binding]; other site 1129794012181 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1129794012182 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1129794012183 G-X-X-G motif; other site 1129794012184 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1129794012185 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1129794012186 putative translocon binding site; other site 1129794012187 protein-rRNA interface [nucleotide binding]; other site 1129794012188 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1129794012189 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1129794012190 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1129794012191 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1129794012192 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1129794012193 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1129794012194 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1129794012195 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1129794012196 GAF domain; Region: GAF; pfam01590 1129794012197 GAF domain; Region: GAF_2; pfam13185 1129794012198 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1129794012199 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1129794012200 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1129794012201 Walker A motif; other site 1129794012202 ATP binding site [chemical binding]; other site 1129794012203 Walker B motif; other site 1129794012204 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1129794012205 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1129794012206 Amidohydrolase; Region: Amidohydro_5; pfam13594 1129794012207 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1129794012208 active site 1129794012209 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794012210 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1129794012211 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1129794012212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794012213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794012214 metal binding site [ion binding]; metal-binding site 1129794012215 active site 1129794012216 I-site; other site 1129794012217 elongation factor G; Reviewed; Region: PRK00007 1129794012218 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1129794012219 G1 box; other site 1129794012220 putative GEF interaction site [polypeptide binding]; other site 1129794012221 GTP/Mg2+ binding site [chemical binding]; other site 1129794012222 Switch I region; other site 1129794012223 G2 box; other site 1129794012224 G3 box; other site 1129794012225 Switch II region; other site 1129794012226 G4 box; other site 1129794012227 G5 box; other site 1129794012228 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1129794012229 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1129794012230 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1129794012231 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1129794012232 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1129794012233 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794012234 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1129794012235 active site 1129794012236 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1129794012237 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1129794012238 active site 1129794012239 catalytic tetrad [active] 1129794012240 elongation factor Tu; Reviewed; Region: PRK00049 1129794012241 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1129794012242 G1 box; other site 1129794012243 GEF interaction site [polypeptide binding]; other site 1129794012244 GTP/Mg2+ binding site [chemical binding]; other site 1129794012245 Switch I region; other site 1129794012246 G2 box; other site 1129794012247 G3 box; other site 1129794012248 Switch II region; other site 1129794012249 G4 box; other site 1129794012250 G5 box; other site 1129794012251 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1129794012252 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1129794012253 Antibiotic Binding Site [chemical binding]; other site 1129794012254 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1129794012255 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1129794012256 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1129794012257 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1129794012258 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1129794012259 FAD binding domain; Region: FAD_binding_4; pfam01565 1129794012260 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1129794012261 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1129794012262 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1129794012263 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1129794012264 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1129794012265 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1129794012266 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1129794012267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794012268 S-adenosylmethionine binding site [chemical binding]; other site 1129794012269 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1129794012270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794012271 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1129794012272 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1129794012273 Di-iron ligands [ion binding]; other site 1129794012274 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794012275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1129794012276 active site 1129794012277 phosphorylation site [posttranslational modification] 1129794012278 intermolecular recognition site; other site 1129794012279 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1129794012280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794012281 metal binding site [ion binding]; metal-binding site 1129794012282 active site 1129794012283 I-site; other site 1129794012284 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794012285 Transmembrane protein 55A; Region: Tmemb_55A; pfam09788 1129794012286 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1129794012287 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794012288 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794012289 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 1129794012290 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 1129794012291 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1129794012292 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1129794012293 Active Sites [active] 1129794012294 sulfite reductase subunit beta; Provisional; Region: PRK13504 1129794012295 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1129794012296 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1129794012297 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1129794012298 Flavodoxin; Region: Flavodoxin_1; pfam00258 1129794012299 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1129794012300 FAD binding pocket [chemical binding]; other site 1129794012301 FAD binding motif [chemical binding]; other site 1129794012302 catalytic residues [active] 1129794012303 NAD binding pocket [chemical binding]; other site 1129794012304 phosphate binding motif [ion binding]; other site 1129794012305 beta-alpha-beta structure motif; other site 1129794012306 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1129794012307 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1129794012308 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1129794012309 phage shock protein A; Region: phageshock_pspA; TIGR02977 1129794012310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1129794012311 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794012312 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1129794012313 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1129794012314 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1129794012315 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1129794012316 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1129794012317 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1129794012318 FMN binding site [chemical binding]; other site 1129794012319 active site 1129794012320 catalytic residues [active] 1129794012321 substrate binding site [chemical binding]; other site 1129794012322 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1129794012323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794012324 ATP binding site [chemical binding]; other site 1129794012325 putative Mg++ binding site [ion binding]; other site 1129794012326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794012327 nucleotide binding region [chemical binding]; other site 1129794012328 ATP-binding site [chemical binding]; other site 1129794012329 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1129794012330 HRDC domain; Region: HRDC; pfam00570 1129794012331 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1129794012332 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1129794012333 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794012334 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1129794012335 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1129794012336 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1129794012337 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1129794012338 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1129794012339 putative acyl-acceptor binding pocket; other site 1129794012340 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1129794012341 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1129794012342 putative acyl-acceptor binding pocket; other site 1129794012343 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1129794012344 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794012345 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1129794012346 hypothetical protein; Provisional; Region: PRK10626 1129794012347 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1129794012348 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1129794012349 putative NAD(P) binding site [chemical binding]; other site 1129794012350 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1129794012351 Na2 binding site [ion binding]; other site 1129794012352 putative substrate binding site 1 [chemical binding]; other site 1129794012353 Na binding site 1 [ion binding]; other site 1129794012354 putative substrate binding site 2 [chemical binding]; other site 1129794012355 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1129794012356 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1129794012357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1129794012358 NAD(P) binding site [chemical binding]; other site 1129794012359 active site 1129794012360 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1129794012361 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1129794012362 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1129794012363 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1129794012364 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1129794012365 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1129794012366 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1129794012367 active site 1129794012368 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1129794012369 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1129794012370 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1129794012371 active site 1129794012372 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1129794012373 substrate binding site [chemical binding]; other site 1129794012374 catalytic residues [active] 1129794012375 dimer interface [polypeptide binding]; other site 1129794012376 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1129794012377 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1129794012378 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1129794012379 Protein of unknown function, DUF484; Region: DUF484; cl17449 1129794012380 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1129794012381 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1129794012382 active site 1129794012383 DNA binding site [nucleotide binding] 1129794012384 Int/Topo IB signature motif; other site 1129794012385 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1129794012386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794012387 motif II; other site 1129794012388 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1129794012389 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1129794012390 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1129794012391 trimer interface [polypeptide binding]; other site 1129794012392 active site 1129794012393 substrate binding site [chemical binding]; other site 1129794012394 CoA binding site [chemical binding]; other site 1129794012395 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1129794012396 Part of AAA domain; Region: AAA_19; pfam13245 1129794012397 Family description; Region: UvrD_C_2; pfam13538 1129794012398 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794012399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794012400 active site 1129794012401 phosphorylation site [posttranslational modification] 1129794012402 intermolecular recognition site; other site 1129794012403 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1129794012404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794012405 active site 1129794012406 phosphorylation site [posttranslational modification] 1129794012407 intermolecular recognition site; other site 1129794012408 dimerization interface [polypeptide binding]; other site 1129794012409 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794012410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794012411 metal binding site [ion binding]; metal-binding site 1129794012412 active site 1129794012413 I-site; other site 1129794012414 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1129794012415 Chromate transporter; Region: Chromate_transp; cl17781 1129794012416 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794012417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794012418 active site 1129794012419 phosphorylation site [posttranslational modification] 1129794012420 intermolecular recognition site; other site 1129794012421 dimerization interface [polypeptide binding]; other site 1129794012422 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794012423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794012424 metal binding site [ion binding]; metal-binding site 1129794012425 active site 1129794012426 I-site; other site 1129794012427 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1129794012428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1129794012429 ATP binding site [chemical binding]; other site 1129794012430 putative Mg++ binding site [ion binding]; other site 1129794012431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1129794012432 nucleotide binding region [chemical binding]; other site 1129794012433 ATP-binding site [chemical binding]; other site 1129794012434 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1129794012435 HRDC domain; Region: HRDC; pfam00570 1129794012436 replicative DNA helicase; Region: DnaB; TIGR00665 1129794012437 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1129794012438 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1129794012439 Walker A motif; other site 1129794012440 ATP binding site [chemical binding]; other site 1129794012441 Walker B motif; other site 1129794012442 DNA binding loops [nucleotide binding] 1129794012443 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1129794012444 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1129794012445 ligand binding site [chemical binding]; other site 1129794012446 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1129794012447 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1129794012448 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1129794012449 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1129794012450 metal binding site 2 [ion binding]; metal-binding site 1129794012451 putative DNA binding helix; other site 1129794012452 metal binding site 1 [ion binding]; metal-binding site 1129794012453 dimer interface [polypeptide binding]; other site 1129794012454 structural Zn2+ binding site [ion binding]; other site 1129794012455 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1129794012456 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1129794012457 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1129794012458 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1129794012459 putative NADH binding site [chemical binding]; other site 1129794012460 putative active site [active] 1129794012461 nudix motif; other site 1129794012462 putative metal binding site [ion binding]; other site 1129794012463 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1129794012464 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1129794012465 substrate binding site [chemical binding]; other site 1129794012466 active site 1129794012467 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1129794012468 metal binding site [ion binding]; metal-binding site 1129794012469 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1129794012470 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1129794012471 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 1129794012472 active site 1129794012473 Zn binding site [ion binding]; other site 1129794012474 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1129794012475 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1129794012476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1129794012477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1129794012478 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1129794012479 AMP binding site [chemical binding]; other site 1129794012480 metal binding site [ion binding]; metal-binding site 1129794012481 active site 1129794012482 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1129794012483 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1129794012484 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1129794012485 dimer interface [polypeptide binding]; other site 1129794012486 substrate binding site [chemical binding]; other site 1129794012487 metal binding sites [ion binding]; metal-binding site 1129794012488 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1129794012489 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1129794012490 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1129794012491 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1129794012492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1129794012493 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1129794012494 active site 1129794012495 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1129794012496 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1129794012497 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1129794012498 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1129794012499 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1129794012500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1129794012501 FeS/SAM binding site; other site 1129794012502 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1129794012503 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1129794012504 ThiS interaction site; other site 1129794012505 putative active site [active] 1129794012506 tetramer interface [polypeptide binding]; other site 1129794012507 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1129794012508 thiS-thiF/thiG interaction site; other site 1129794012509 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1129794012510 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1129794012511 ATP binding site [chemical binding]; other site 1129794012512 substrate interface [chemical binding]; other site 1129794012513 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1129794012514 dimer interface [polypeptide binding]; other site 1129794012515 HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898 1129794012516 substrate binding site [chemical binding]; other site 1129794012517 ATP binding site [chemical binding]; other site 1129794012518 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1129794012519 active site 1129794012520 thiamine phosphate binding site [chemical binding]; other site 1129794012521 pyrophosphate binding site [ion binding]; other site 1129794012522 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1129794012523 ThiC-associated domain; Region: ThiC-associated; pfam13667 1129794012524 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1129794012525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794012526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794012527 putative substrate translocation pore; other site 1129794012528 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1129794012529 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1129794012530 dimer interface [polypeptide binding]; other site 1129794012531 ssDNA binding site [nucleotide binding]; other site 1129794012532 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1129794012533 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1129794012534 putative diguanylate cyclase; Provisional; Region: PRK09776 1129794012535 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1129794012536 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794012537 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794012538 N-terminal plug; other site 1129794012539 ligand-binding site [chemical binding]; other site 1129794012540 PAS fold; Region: PAS_4; pfam08448 1129794012541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1129794012542 putative active site [active] 1129794012543 heme pocket [chemical binding]; other site 1129794012544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794012545 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794012546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794012547 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1129794012548 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1129794012549 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1129794012550 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 1129794012551 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1129794012552 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1129794012553 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1129794012554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1129794012555 Walker A motif; other site 1129794012556 ATP binding site [chemical binding]; other site 1129794012557 Walker B motif; other site 1129794012558 arginine finger; other site 1129794012559 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1129794012560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1129794012561 TPR motif; other site 1129794012562 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1129794012563 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1129794012564 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1129794012565 Walker A motif; other site 1129794012566 ATP binding site [chemical binding]; other site 1129794012567 Walker B motif; other site 1129794012568 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1129794012569 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1129794012570 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1129794012571 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1129794012572 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1129794012573 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1129794012574 rod shape-determining protein MreB; Provisional; Region: PRK13927 1129794012575 MreB and similar proteins; Region: MreB_like; cd10225 1129794012576 nucleotide binding site [chemical binding]; other site 1129794012577 Mg binding site [ion binding]; other site 1129794012578 putative protofilament interaction site [polypeptide binding]; other site 1129794012579 RodZ interaction site [polypeptide binding]; other site 1129794012580 rod shape-determining protein MreC; Provisional; Region: PRK13922 1129794012581 rod shape-determining protein MreC; Region: MreC; pfam04085 1129794012582 rod shape-determining protein MreD; Region: MreD; cl01087 1129794012583 Maf-like protein; Region: Maf; pfam02545 1129794012584 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1129794012585 active site 1129794012586 dimer interface [polypeptide binding]; other site 1129794012587 ribonuclease G; Provisional; Region: PRK11712 1129794012588 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1129794012589 homodimer interface [polypeptide binding]; other site 1129794012590 oligonucleotide binding site [chemical binding]; other site 1129794012591 Protein of unknown function; Region: DUF3971; pfam13116 1129794012592 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1129794012593 nitrilase; Region: PLN02798 1129794012594 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1129794012595 putative active site [active] 1129794012596 catalytic triad [active] 1129794012597 dimer interface [polypeptide binding]; other site 1129794012598 protease TldD; Provisional; Region: tldD; PRK10735 1129794012599 hypothetical protein; Provisional; Region: PRK05255 1129794012600 peptidase PmbA; Provisional; Region: PRK11040 1129794012601 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1129794012602 dimerization interface [polypeptide binding]; other site 1129794012603 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794012604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794012605 metal binding site [ion binding]; metal-binding site 1129794012606 active site 1129794012607 I-site; other site 1129794012608 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1129794012609 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 1129794012610 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1129794012611 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1129794012612 ligand binding site [chemical binding]; other site 1129794012613 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1129794012614 HlyD family secretion protein; Region: HlyD_3; pfam13437 1129794012615 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1129794012616 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1129794012617 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1129794012618 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1129794012619 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1129794012620 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1129794012621 Walker A/P-loop; other site 1129794012622 ATP binding site [chemical binding]; other site 1129794012623 Q-loop/lid; other site 1129794012624 ABC transporter signature motif; other site 1129794012625 Walker B; other site 1129794012626 D-loop; other site 1129794012627 H-loop/switch region; other site 1129794012628 VCBS repeat; Region: VCBS_repeat; TIGR01965 1129794012629 VCBS repeat; Region: VCBS_repeat; TIGR01965 1129794012630 VCBS repeat; Region: VCBS_repeat; TIGR01965 1129794012631 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 1129794012632 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1129794012633 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1129794012634 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1129794012635 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 1129794012636 putative ligand binding site [chemical binding]; other site 1129794012637 proline dipeptidase; Provisional; Region: PRK13607 1129794012638 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1129794012639 active site 1129794012640 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794012641 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1129794012642 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1129794012643 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1129794012644 catalytic residue [active] 1129794012645 lytic murein transglycosylase; Provisional; Region: PRK11619 1129794012646 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1129794012647 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1129794012648 substrate binding site [chemical binding]; other site 1129794012649 oxyanion hole (OAH) forming residues; other site 1129794012650 trimer interface [polypeptide binding]; other site 1129794012651 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1129794012652 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1129794012653 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1129794012654 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1129794012655 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1129794012656 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1129794012657 dimer interface [polypeptide binding]; other site 1129794012658 active site 1129794012659 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1129794012660 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1129794012661 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1129794012662 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1129794012663 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1129794012664 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1129794012665 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1129794012666 dimerization interface [polypeptide binding]; other site 1129794012667 DPS ferroxidase diiron center [ion binding]; other site 1129794012668 ion pore; other site 1129794012669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1129794012670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1129794012671 putative metal binding site [ion binding]; other site 1129794012672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794012673 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794012674 active site 1129794012675 phosphorylation site [posttranslational modification] 1129794012676 intermolecular recognition site; other site 1129794012677 dimerization interface [polypeptide binding]; other site 1129794012678 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1129794012679 Beta-lactamase; Region: Beta-lactamase; pfam00144 1129794012680 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1129794012681 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1129794012682 NAD binding site [chemical binding]; other site 1129794012683 homodimer interface [polypeptide binding]; other site 1129794012684 homotetramer interface [polypeptide binding]; other site 1129794012685 active site 1129794012686 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1129794012687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1129794012688 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794012689 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794012690 N-terminal plug; other site 1129794012691 ligand-binding site [chemical binding]; other site 1129794012692 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1129794012693 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1129794012694 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1129794012695 acyl-activating enzyme (AAE) consensus motif; other site 1129794012696 putative AMP binding site [chemical binding]; other site 1129794012697 putative active site [active] 1129794012698 putative CoA binding site [chemical binding]; other site 1129794012699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794012700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794012701 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1129794012702 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1129794012703 active site 1129794012704 dimer interface [polypeptide binding]; other site 1129794012705 metal binding site [ion binding]; metal-binding site 1129794012706 acyl-CoA synthetase; Validated; Region: PRK08162 1129794012707 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1129794012708 acyl-activating enzyme (AAE) consensus motif; other site 1129794012709 putative active site [active] 1129794012710 AMP binding site [chemical binding]; other site 1129794012711 putative CoA binding site [chemical binding]; other site 1129794012712 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1129794012713 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1129794012714 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1129794012715 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1129794012716 GDP-binding site [chemical binding]; other site 1129794012717 ACT binding site; other site 1129794012718 IMP binding site; other site 1129794012719 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1129794012720 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 1129794012721 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1129794012722 Integrase core domain; Region: rve; pfam00665 1129794012723 putative transposase OrfB; Reviewed; Region: PHA02517 1129794012724 Transposase; Region: HTH_Tnp_1; pfam01527 1129794012725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794012726 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1129794012727 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1129794012728 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1129794012729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1129794012730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1129794012731 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1129794012732 Integrase core domain; Region: rve; pfam00665 1129794012733 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1129794012734 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794012735 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1129794012736 active site 1129794012737 putative transporter; Provisional; Region: PRK03699 1129794012738 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 1129794012739 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1129794012740 active site 1129794012741 putative substrate binding pocket [chemical binding]; other site 1129794012742 xanthine permease; Region: pbuX; TIGR03173 1129794012743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1129794012744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1129794012745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1129794012746 dimerization interface [polypeptide binding]; other site 1129794012747 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1129794012748 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1129794012749 putative acyl-acceptor binding pocket; other site 1129794012750 LexA repressor; Validated; Region: PRK00215 1129794012751 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1129794012752 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1129794012753 Catalytic site [active] 1129794012754 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00139 1129794012755 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1129794012756 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1129794012757 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1129794012758 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1129794012759 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1129794012760 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1129794012761 Subunit I/III interface [polypeptide binding]; other site 1129794012762 D-pathway; other site 1129794012763 Subunit I/VIIc interface [polypeptide binding]; other site 1129794012764 Subunit I/IV interface [polypeptide binding]; other site 1129794012765 Subunit I/II interface [polypeptide binding]; other site 1129794012766 Low-spin heme (heme a) binding site [chemical binding]; other site 1129794012767 Subunit I/VIIa interface [polypeptide binding]; other site 1129794012768 Subunit I/VIa interface [polypeptide binding]; other site 1129794012769 Dimer interface; other site 1129794012770 Putative water exit pathway; other site 1129794012771 Binuclear center (heme a3/CuB) [ion binding]; other site 1129794012772 K-pathway; other site 1129794012773 Subunit I/Vb interface [polypeptide binding]; other site 1129794012774 Putative proton exit pathway; other site 1129794012775 Subunit I/VIb interface; other site 1129794012776 Subunit I/VIc interface [polypeptide binding]; other site 1129794012777 Electron transfer pathway; other site 1129794012778 Subunit I/VIIIb interface [polypeptide binding]; other site 1129794012779 Subunit I/VIIb interface [polypeptide binding]; other site 1129794012780 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1129794012781 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1129794012782 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1129794012783 Subunit I/III interface [polypeptide binding]; other site 1129794012784 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1129794012785 Subunit III/VIb interface [polypeptide binding]; other site 1129794012786 Subunit III/VIa interface; other site 1129794012787 Subunit III/Vb interface [polypeptide binding]; other site 1129794012788 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1129794012789 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1129794012790 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1129794012791 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1129794012792 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1129794012793 UbiA prenyltransferase family; Region: UbiA; pfam01040 1129794012794 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1129794012795 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1129794012796 Cu(I) binding site [ion binding]; other site 1129794012797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1129794012798 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1129794012799 Coenzyme A binding pocket [chemical binding]; other site 1129794012800 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 1129794012801 putative active site [active] 1129794012802 putative metal binding site [ion binding]; other site 1129794012803 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1129794012804 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1129794012805 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1129794012806 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1129794012807 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1129794012808 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 1129794012809 putative active site [active] 1129794012810 Zn binding site [ion binding]; other site 1129794012811 comF family protein; Region: comF; TIGR00201 1129794012812 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1129794012813 active site 1129794012814 SprA-related family; Region: SprA-related; pfam12118 1129794012815 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1129794012816 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1129794012817 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1129794012818 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1129794012819 RNA binding site [nucleotide binding]; other site 1129794012820 Predicted deacylase [General function prediction only]; Region: COG3608 1129794012821 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 1129794012822 putative active site [active] 1129794012823 Zn binding site [ion binding]; other site 1129794012824 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1129794012825 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1129794012826 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1129794012827 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1129794012828 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1129794012829 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1129794012830 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1129794012831 Protein of unknown function (DUF502); Region: DUF502; pfam04367 1129794012832 Domain of unknown function DUF21; Region: DUF21; pfam01595 1129794012833 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1129794012834 Domain of unknown function DUF21; Region: DUF21; pfam01595 1129794012835 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1129794012836 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1129794012837 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794012838 Conserved TM helix; Region: TM_helix; pfam05552 1129794012839 Conserved TM helix; Region: TM_helix; pfam05552 1129794012840 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 1129794012841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794012842 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1129794012843 DNA binding residues [nucleotide binding] 1129794012844 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1129794012845 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1129794012846 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1129794012847 CHAP domain; Region: CHAP; pfam05257 1129794012848 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1129794012849 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1129794012850 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794012851 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1129794012852 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794012853 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1129794012854 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1129794012855 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1129794012856 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1129794012857 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1129794012858 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1129794012859 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1129794012860 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1129794012861 PQQ-like domain; Region: PQQ_2; pfam13360 1129794012862 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1129794012863 structural tetrad; other site 1129794012864 SlyX; Region: SlyX; pfam04102 1129794012865 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 1129794012866 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1129794012867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794012868 Walker A/P-loop; other site 1129794012869 ATP binding site [chemical binding]; other site 1129794012870 Q-loop/lid; other site 1129794012871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794012872 ABC transporter; Region: ABC_tran_2; pfam12848 1129794012873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1129794012874 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1129794012875 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794012876 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1129794012877 N-terminal plug; other site 1129794012878 ligand-binding site [chemical binding]; other site 1129794012879 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1129794012880 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1129794012881 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1129794012882 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1129794012883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1129794012884 putative hydrolase; Provisional; Region: PRK10985 1129794012885 Uncharacterized protein family (UPF0270); Region: UPF0270; cl01180 1129794012886 YceI-like domain; Region: YceI; pfam04264 1129794012887 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1129794012888 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1129794012889 active site 1129794012890 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1129794012891 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1129794012892 dimer interface [polypeptide binding]; other site 1129794012893 ADP-ribose binding site [chemical binding]; other site 1129794012894 active site 1129794012895 nudix motif; other site 1129794012896 metal binding site [ion binding]; metal-binding site 1129794012897 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1129794012898 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1129794012899 motif II; other site 1129794012900 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1129794012901 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 1129794012902 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1129794012903 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1129794012904 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1129794012905 GspL periplasmic domain; Region: GspL_C; pfam12693 1129794012906 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1129794012907 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1129794012908 type II secretion system protein J; Region: gspJ; TIGR01711 1129794012909 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1129794012910 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1129794012911 type II secretion system protein I; Region: gspI; TIGR01707 1129794012912 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1129794012913 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1129794012914 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1129794012915 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1129794012916 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1129794012917 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1129794012918 type II secretion system protein F; Region: GspF; TIGR02120 1129794012919 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1129794012920 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1129794012921 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1129794012922 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1129794012923 Walker A motif; other site 1129794012924 ATP binding site [chemical binding]; other site 1129794012925 Walker B motif; other site 1129794012926 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1129794012927 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1129794012928 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1129794012929 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1129794012930 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1129794012931 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1129794012932 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1129794012933 protein binding site [polypeptide binding]; other site 1129794012934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1129794012935 RNA binding surface [nucleotide binding]; other site 1129794012936 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1129794012937 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1129794012938 dimerization interface [polypeptide binding]; other site 1129794012939 domain crossover interface; other site 1129794012940 redox-dependent activation switch; other site 1129794012941 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1129794012942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1129794012943 metal binding site [ion binding]; metal-binding site 1129794012944 active site 1129794012945 I-site; other site 1129794012946 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1129794012947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1129794012948 dimerization interface [polypeptide binding]; other site 1129794012949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794012950 dimer interface [polypeptide binding]; other site 1129794012951 phosphorylation site [posttranslational modification] 1129794012952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794012953 ATP binding site [chemical binding]; other site 1129794012954 Mg2+ binding site [ion binding]; other site 1129794012955 G-X-G motif; other site 1129794012956 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1129794012957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794012958 active site 1129794012959 phosphorylation site [posttranslational modification] 1129794012960 intermolecular recognition site; other site 1129794012961 dimerization interface [polypeptide binding]; other site 1129794012962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1129794012963 DNA binding site [nucleotide binding] 1129794012964 phosphoribulokinase; Provisional; Region: PRK15453 1129794012965 Ion channel; Region: Ion_trans_2; pfam07885 1129794012966 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1129794012967 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1129794012968 mercuric reductase; Validated; Region: PRK06370 1129794012969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1129794012970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1129794012971 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1129794012972 Protein of unknown function, DUF547; Region: DUF547; pfam04784 1129794012973 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1129794012974 hypothetical protein; Provisional; Region: PRK11622 1129794012975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794012976 dimer interface [polypeptide binding]; other site 1129794012977 conserved gate region; other site 1129794012978 ABC-ATPase subunit interface; other site 1129794012979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1129794012980 dimer interface [polypeptide binding]; other site 1129794012981 putative PBP binding loops; other site 1129794012982 ABC-ATPase subunit interface; other site 1129794012983 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1129794012984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1129794012985 Walker A/P-loop; other site 1129794012986 ATP binding site [chemical binding]; other site 1129794012987 Q-loop/lid; other site 1129794012988 ABC transporter signature motif; other site 1129794012989 Walker B; other site 1129794012990 D-loop; other site 1129794012991 H-loop/switch region; other site 1129794012992 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1129794012993 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1129794012994 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1129794012995 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1129794012996 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 1129794012997 Endonuclease I; Region: Endonuclease_1; cl01003 1129794012998 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1129794012999 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1129794013000 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1129794013001 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1129794013002 Predicted methyltransferase [General function prediction only]; Region: COG4798 1129794013003 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1129794013004 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1129794013005 dimer interface [polypeptide binding]; other site 1129794013006 putative catalytic residues [active] 1129794013007 purine monophosphate binding site [chemical binding]; other site 1129794013008 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1129794013009 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1129794013010 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1129794013011 substrate binding site [chemical binding]; other site 1129794013012 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1129794013013 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1129794013014 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1129794013015 FMN binding site [chemical binding]; other site 1129794013016 active site 1129794013017 catalytic residues [active] 1129794013018 substrate binding site [chemical binding]; other site 1129794013019 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1129794013020 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1129794013021 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1129794013022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794013023 binding surface 1129794013024 TPR motif; other site 1129794013025 Carboxylesterase family; Region: COesterase; pfam00135 1129794013026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1129794013027 substrate binding pocket [chemical binding]; other site 1129794013028 catalytic triad [active] 1129794013029 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1129794013030 Transposase; Region: HTH_Tnp_1; pfam01527 1129794013031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794013032 Integrase core domain; Region: rve; pfam00665 1129794013033 Integrase core domain; Region: rve_3; pfam13683 1129794013034 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1129794013035 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1129794013036 Transposase; Region: HTH_Tnp_1; pfam01527 1129794013037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1129794013038 Integrase core domain; Region: rve; pfam00665 1129794013039 Integrase core domain; Region: rve_3; pfam13683 1129794013040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1129794013041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1129794013042 putative substrate translocation pore; other site 1129794013043 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1129794013044 active site clefts [active] 1129794013045 zinc binding site [ion binding]; other site 1129794013046 dimer interface [polypeptide binding]; other site 1129794013047 agmatinase; Region: agmatinase; TIGR01230 1129794013048 Agmatinase-like family; Region: Agmatinase-like; cd09990 1129794013049 active site 1129794013050 oligomer interface [polypeptide binding]; other site 1129794013051 Mn binding site [ion binding]; other site 1129794013052 agmatinase; Region: agmatinase; TIGR01230 1129794013053 Agmatinase-like family; Region: Agmatinase-like; cd09990 1129794013054 active site 1129794013055 oligomer interface [polypeptide binding]; other site 1129794013056 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794013057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794013058 active site 1129794013059 phosphorylation site [posttranslational modification] 1129794013060 intermolecular recognition site; other site 1129794013061 dimerization interface [polypeptide binding]; other site 1129794013062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1129794013063 DNA binding residues [nucleotide binding] 1129794013064 dimerization interface [polypeptide binding]; other site 1129794013065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1129794013066 binding surface 1129794013067 TPR motif; other site 1129794013068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1129794013069 TPR repeat; Region: TPR_11; pfam13414 1129794013070 binding surface 1129794013071 TPR motif; other site 1129794013072 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1129794013073 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1129794013074 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1129794013075 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794013076 Agmatinase-like family; Region: Agmatinase-like; cd09990 1129794013077 active site 1129794013078 oligomer interface [polypeptide binding]; other site 1129794013079 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1129794013080 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1129794013081 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1129794013082 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1129794013083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794013084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794013085 dimer interface [polypeptide binding]; other site 1129794013086 phosphorylation site [posttranslational modification] 1129794013087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794013088 ATP binding site [chemical binding]; other site 1129794013089 Mg2+ binding site [ion binding]; other site 1129794013090 G-X-G motif; other site 1129794013091 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794013092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794013093 active site 1129794013094 phosphorylation site [posttranslational modification] 1129794013095 intermolecular recognition site; other site 1129794013096 dimerization interface [polypeptide binding]; other site 1129794013097 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1129794013098 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1129794013099 putative ligand binding site [chemical binding]; other site 1129794013100 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1129794013101 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1129794013102 TM-ABC transporter signature motif; other site 1129794013103 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1129794013104 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1129794013105 TM-ABC transporter signature motif; other site 1129794013106 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1129794013107 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1129794013108 Walker A/P-loop; other site 1129794013109 ATP binding site [chemical binding]; other site 1129794013110 Q-loop/lid; other site 1129794013111 ABC transporter signature motif; other site 1129794013112 Walker B; other site 1129794013113 D-loop; other site 1129794013114 H-loop/switch region; other site 1129794013115 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1129794013116 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1129794013117 Walker A/P-loop; other site 1129794013118 ATP binding site [chemical binding]; other site 1129794013119 Q-loop/lid; other site 1129794013120 ABC transporter signature motif; other site 1129794013121 Walker B; other site 1129794013122 D-loop; other site 1129794013123 H-loop/switch region; other site 1129794013124 UreD urease accessory protein; Region: UreD; pfam01774 1129794013125 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1129794013126 alpha-gamma subunit interface [polypeptide binding]; other site 1129794013127 beta-gamma subunit interface [polypeptide binding]; other site 1129794013128 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1129794013129 gamma-beta subunit interface [polypeptide binding]; other site 1129794013130 alpha-beta subunit interface [polypeptide binding]; other site 1129794013131 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1129794013132 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1129794013133 subunit interactions [polypeptide binding]; other site 1129794013134 active site 1129794013135 flap region; other site 1129794013136 urease accessory protein UreE; Provisional; Region: PRK14113 1129794013137 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1129794013138 dimer interface [polypeptide binding]; other site 1129794013139 catalytic residues [active] 1129794013140 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1129794013141 UreF; Region: UreF; pfam01730 1129794013142 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1129794013143 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1129794013144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1129794013145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1129794013146 DNA binding residues [nucleotide binding] 1129794013147 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1129794013148 EamA-like transporter family; Region: EamA; pfam00892 1129794013149 hypothetical protein; Provisional; Region: PRK08262 1129794013150 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 1129794013151 metal binding site [ion binding]; metal-binding site 1129794013152 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1129794013153 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1129794013154 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1129794013155 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1129794013156 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1129794013157 putative catalytic cysteine [active] 1129794013158 gamma-glutamyl kinase; Provisional; Region: PRK05429 1129794013159 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1129794013160 nucleotide binding site [chemical binding]; other site 1129794013161 homotetrameric interface [polypeptide binding]; other site 1129794013162 putative phosphate binding site [ion binding]; other site 1129794013163 putative allosteric binding site; other site 1129794013164 PUA domain; Region: PUA; pfam01472 1129794013165 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1129794013166 Zn binding site [ion binding]; other site 1129794013167 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1129794013168 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1129794013169 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1129794013170 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 1129794013171 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1129794013172 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1129794013173 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1129794013174 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1129794013175 active site 1129794013176 Predicted methyltransferase [General function prediction only]; Region: COG4798 1129794013177 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1129794013178 CPxP motif; other site 1129794013179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1129794013180 active site 1129794013181 ribonuclease PH; Reviewed; Region: rph; PRK00173 1129794013182 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1129794013183 hexamer interface [polypeptide binding]; other site 1129794013184 active site 1129794013185 hypothetical protein; Provisional; Region: PRK11820 1129794013186 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1129794013187 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1129794013188 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1129794013189 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1129794013190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1129794013191 Zn2+ binding site [ion binding]; other site 1129794013192 Mg2+ binding site [ion binding]; other site 1129794013193 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1129794013194 DNA binding site [nucleotide binding] 1129794013195 active site 1129794013196 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1129794013197 Chain length determinant protein; Region: Wzz; cl15801 1129794013198 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1129794013199 active site 1129794013200 catalytic residues [active] 1129794013201 DNA binding site [nucleotide binding] 1129794013202 Int/Topo IB signature motif; other site 1129794013203 DTW domain; Region: DTW; cl01221 1129794013204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1129794013205 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1129794013206 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1129794013207 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794013208 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1129794013209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1129794013210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1129794013211 dimer interface [polypeptide binding]; other site 1129794013212 phosphorylation site [posttranslational modification] 1129794013213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1129794013214 ATP binding site [chemical binding]; other site 1129794013215 Mg2+ binding site [ion binding]; other site 1129794013216 G-X-G motif; other site 1129794013217 Response regulator receiver domain; Region: Response_reg; pfam00072 1129794013218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794013219 active site 1129794013220 phosphorylation site [posttranslational modification] 1129794013221 intermolecular recognition site; other site 1129794013222 dimerization interface [polypeptide binding]; other site 1129794013223 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1129794013224 putative binding surface; other site 1129794013225 active site 1129794013226 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1129794013227 Cytochrome c; Region: Cytochrom_C; cl11414 1129794013228 Cytochrome c; Region: Cytochrom_C; cl11414 1129794013229 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1129794013230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1129794013231 active site 1129794013232 phosphorylation site [posttranslational modification] 1129794013233 intermolecular recognition site; other site 1129794013234 dimerization interface [polypeptide binding]; other site 1129794013235 LytTr DNA-binding domain; Region: LytTR; smart00850 1129794013236 Histidine kinase; Region: His_kinase; pfam06580 1129794013237 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794013238 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1129794013239 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 1129794013240 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1129794013241 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1129794013242 gamma subunit interface [polypeptide binding]; other site 1129794013243 epsilon subunit interface [polypeptide binding]; other site 1129794013244 LBP interface [polypeptide binding]; other site 1129794013245 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1129794013246 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1129794013247 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1129794013248 alpha subunit interaction interface [polypeptide binding]; other site 1129794013249 Walker A motif; other site 1129794013250 ATP binding site [chemical binding]; other site 1129794013251 Walker B motif; other site 1129794013252 inhibitor binding site; inhibition site 1129794013253 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1129794013254 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1129794013255 core domain interface [polypeptide binding]; other site 1129794013256 delta subunit interface [polypeptide binding]; other site 1129794013257 epsilon subunit interface [polypeptide binding]; other site 1129794013258 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1129794013259 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1129794013260 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1129794013261 beta subunit interaction interface [polypeptide binding]; other site 1129794013262 Walker A motif; other site 1129794013263 ATP binding site [chemical binding]; other site 1129794013264 Walker B motif; other site 1129794013265 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1129794013266 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1129794013267 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1129794013268 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1129794013269 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1129794013270 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1129794013271 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1129794013272 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1129794013273 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1129794013274 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1129794013275 ParB-like nuclease domain; Region: ParBc; pfam02195 1129794013276 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1129794013277 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1129794013278 P-loop; other site 1129794013279 Magnesium ion binding site [ion binding]; other site 1129794013280 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1129794013281 Magnesium ion binding site [ion binding]; other site 1129794013282 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1129794013283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1129794013284 S-adenosylmethionine binding site [chemical binding]; other site 1129794013285 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1129794013286 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1129794013287 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1129794013288 hypothetical protein; Validated; Region: PRK08116 1129794013289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1129794013290 primosomal protein DnaI; Provisional; Region: PRK02854 1129794013291 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1129794013292 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1129794013293 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1129794013294 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1129794013295 G1 box; other site 1129794013296 GTP/Mg2+ binding site [chemical binding]; other site 1129794013297 Switch I region; other site 1129794013298 G2 box; other site 1129794013299 Switch II region; other site 1129794013300 G3 box; other site 1129794013301 G4 box; other site 1129794013302 G5 box; other site 1129794013303 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1129794013304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1129794013305 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1129794013306 membrane protein insertase; Provisional; Region: PRK01318 1129794013307 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1129794013308 Ribonuclease P; Region: Ribonuclease_P; cl00457 1129794013309 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399