-- dump date 20140619_103003 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1183438000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1183438000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1183438000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438000004 Walker A motif; other site 1183438000005 ATP binding site [chemical binding]; other site 1183438000006 Walker B motif; other site 1183438000007 arginine finger; other site 1183438000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1183438000009 DnaA box-binding interface [nucleotide binding]; other site 1183438000010 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1183438000011 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1183438000012 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1183438000013 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1183438000014 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1183438000015 Predicted ATPase [General function prediction only]; Region: COG4637 1183438000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438000017 Walker A/P-loop; other site 1183438000018 ATP binding site [chemical binding]; other site 1183438000019 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1183438000020 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1183438000021 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438000022 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1183438000023 ABC1 family; Region: ABC1; cl17513 1183438000024 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1183438000025 GSH binding site [chemical binding]; other site 1183438000026 catalytic residues [active] 1183438000027 glutathione synthetase; Provisional; Region: PRK05246 1183438000028 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1183438000029 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1183438000030 carboxylate-amine ligase; Provisional; Region: PRK13517 1183438000031 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1183438000032 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 1183438000033 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 1183438000034 dimerization interface [polypeptide binding]; other site 1183438000035 FAD binding pocket [chemical binding]; other site 1183438000036 FAD binding motif [chemical binding]; other site 1183438000037 catalytic residues [active] 1183438000038 NAD binding pocket [chemical binding]; other site 1183438000039 phosphate binding motif [ion binding]; other site 1183438000040 beta-alpha-beta structure motif; other site 1183438000041 phosphoribulokinase; Provisional; Region: PRK07429 1183438000042 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1183438000043 active site 1183438000044 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1183438000045 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1183438000046 TPP-binding site [chemical binding]; other site 1183438000047 dimer interface [polypeptide binding]; other site 1183438000048 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1183438000049 PYR/PP interface [polypeptide binding]; other site 1183438000050 dimer interface [polypeptide binding]; other site 1183438000051 TPP binding site [chemical binding]; other site 1183438000052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1183438000053 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1183438000054 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1183438000055 dimer interface [polypeptide binding]; other site 1183438000056 ssDNA binding site [nucleotide binding]; other site 1183438000057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1183438000058 nitrilase; Region: PLN02798 1183438000059 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1183438000060 putative active site [active] 1183438000061 catalytic triad [active] 1183438000062 dimer interface [polypeptide binding]; other site 1183438000063 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 1183438000064 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1183438000065 catalytic loop [active] 1183438000066 iron binding site [ion binding]; other site 1183438000067 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 1183438000068 Cysteine-rich domain; Region: CCG; pfam02754 1183438000069 Cysteine-rich domain; Region: CCG; pfam02754 1183438000070 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 1183438000071 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438000072 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1183438000073 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 1183438000074 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1183438000075 ligand binding site; other site 1183438000076 oligomer interface; other site 1183438000077 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1183438000078 dimer interface [polypeptide binding]; other site 1183438000079 N-terminal domain interface [polypeptide binding]; other site 1183438000080 sulfate 1 binding site; other site 1183438000081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000082 binding surface 1183438000083 TPR motif; other site 1183438000084 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438000085 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1183438000086 amphipathic channel; other site 1183438000087 Asn-Pro-Ala signature motifs; other site 1183438000088 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1183438000089 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1183438000090 molybdopterin cofactor binding site; other site 1183438000091 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1183438000092 molybdopterin cofactor binding site; other site 1183438000093 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 1183438000094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438000095 FeS/SAM binding site; other site 1183438000096 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1183438000097 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1183438000098 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1183438000099 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1183438000100 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1183438000101 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1183438000102 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1183438000103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1183438000104 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1183438000105 dimerization interface [polypeptide binding]; other site 1183438000106 substrate binding pocket [chemical binding]; other site 1183438000107 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1183438000108 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1183438000109 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1183438000110 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1183438000111 NAD(P) binding site [chemical binding]; other site 1183438000112 catalytic residues [active] 1183438000113 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438000114 catalytic motif [active] 1183438000115 Catalytic residue [active] 1183438000116 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438000117 catalytic motif [active] 1183438000118 Catalytic residue [active] 1183438000119 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438000120 protein binding site [polypeptide binding]; other site 1183438000121 FecCD transport family; Region: FecCD; pfam01032 1183438000122 putative PBP binding regions; other site 1183438000123 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1183438000124 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1183438000125 putative ligand binding site [chemical binding]; other site 1183438000126 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1183438000127 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1183438000128 NAD(P) binding site [chemical binding]; other site 1183438000129 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1183438000130 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1183438000131 Walker A/P-loop; other site 1183438000132 ATP binding site [chemical binding]; other site 1183438000133 Q-loop/lid; other site 1183438000134 ABC transporter signature motif; other site 1183438000135 Walker B; other site 1183438000136 D-loop; other site 1183438000137 H-loop/switch region; other site 1183438000138 Heat induced stress protein YflT; Region: YflT; pfam11181 1183438000139 glycine dehydrogenase; Provisional; Region: PRK05367 1183438000140 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1183438000141 tetramer interface [polypeptide binding]; other site 1183438000142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438000143 catalytic residue [active] 1183438000144 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1183438000145 tetramer interface [polypeptide binding]; other site 1183438000146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438000147 catalytic residue [active] 1183438000148 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438000149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438000150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438000151 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438000152 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1183438000153 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1183438000154 Walker A/P-loop; other site 1183438000155 ATP binding site [chemical binding]; other site 1183438000156 Q-loop/lid; other site 1183438000157 ABC transporter signature motif; other site 1183438000158 Walker B; other site 1183438000159 D-loop; other site 1183438000160 H-loop/switch region; other site 1183438000161 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1183438000162 PLD-like domain; Region: PLDc_2; pfam13091 1183438000163 putative active site [active] 1183438000164 catalytic site [active] 1183438000165 PLD-like domain; Region: PLDc_2; pfam13091 1183438000166 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1183438000167 putative active site [active] 1183438000168 catalytic site [active] 1183438000169 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1183438000170 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1183438000171 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1183438000172 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1183438000173 allophanate hydrolase; Provisional; Region: PRK08186 1183438000174 Amidase; Region: Amidase; pfam01425 1183438000175 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438000176 putative active site [active] 1183438000177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1183438000178 dimerization interface [polypeptide binding]; other site 1183438000179 putative DNA binding site [nucleotide binding]; other site 1183438000180 putative Zn2+ binding site [ion binding]; other site 1183438000181 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 1183438000182 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1183438000183 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1183438000184 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438000185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438000186 putative active site [active] 1183438000187 heme pocket [chemical binding]; other site 1183438000188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438000189 dimer interface [polypeptide binding]; other site 1183438000190 phosphorylation site [posttranslational modification] 1183438000191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438000192 ATP binding site [chemical binding]; other site 1183438000193 Mg2+ binding site [ion binding]; other site 1183438000194 G-X-G motif; other site 1183438000195 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438000196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438000197 active site 1183438000198 phosphorylation site [posttranslational modification] 1183438000199 intermolecular recognition site; other site 1183438000200 dimerization interface [polypeptide binding]; other site 1183438000201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438000202 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1183438000203 H+ Antiporter protein; Region: 2A0121; TIGR00900 1183438000204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438000205 putative substrate translocation pore; other site 1183438000206 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1183438000207 Recombination protein O N terminal; Region: RecO_N; pfam11967 1183438000208 Recombination protein O C terminal; Region: RecO_C; pfam02565 1183438000209 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1183438000210 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1183438000211 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1183438000212 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1183438000213 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1183438000214 Walker A/P-loop; other site 1183438000215 ATP binding site [chemical binding]; other site 1183438000216 Q-loop/lid; other site 1183438000217 ABC transporter signature motif; other site 1183438000218 Walker B; other site 1183438000219 D-loop; other site 1183438000220 H-loop/switch region; other site 1183438000221 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1183438000222 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1183438000223 ring oligomerisation interface [polypeptide binding]; other site 1183438000224 ATP/Mg binding site [chemical binding]; other site 1183438000225 stacking interactions; other site 1183438000226 hinge regions; other site 1183438000227 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1183438000228 oligomerisation interface [polypeptide binding]; other site 1183438000229 mobile loop; other site 1183438000230 roof hairpin; other site 1183438000231 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1183438000232 Predicted transcriptional regulator [Transcription]; Region: COG2378 1183438000233 WYL domain; Region: WYL; pfam13280 1183438000234 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1183438000235 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1183438000236 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1183438000237 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1183438000238 putative active site [active] 1183438000239 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1183438000240 RuvA N terminal domain; Region: RuvA_N; pfam01330 1183438000241 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1183438000242 CAAX protease self-immunity; Region: Abi; pfam02517 1183438000243 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1183438000244 Ycf35; Provisional; Region: ycf35; CHL00193 1183438000245 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1183438000246 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1183438000247 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1183438000248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438000249 active site 1183438000250 metal binding site [ion binding]; metal-binding site 1183438000251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1183438000252 binding surface 1183438000253 TPR motif; other site 1183438000254 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1183438000255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438000256 NifU-like domain; Region: NifU; pfam01106 1183438000257 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1183438000258 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1183438000259 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1183438000260 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1183438000261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438000262 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 1183438000263 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1183438000264 Family description; Region: VCBS; pfam13517 1183438000265 Family description; Region: VCBS; pfam13517 1183438000266 Family description; Region: VCBS; pfam13517 1183438000267 Family description; Region: VCBS; pfam13517 1183438000268 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1183438000269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1183438000270 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1183438000271 Walker A/P-loop; other site 1183438000272 ATP binding site [chemical binding]; other site 1183438000273 Q-loop/lid; other site 1183438000274 ABC transporter signature motif; other site 1183438000275 Walker B; other site 1183438000276 D-loop; other site 1183438000277 H-loop/switch region; other site 1183438000278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000279 TPR motif; other site 1183438000280 TPR repeat; Region: TPR_11; pfam13414 1183438000281 binding surface 1183438000282 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1183438000283 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1183438000284 dimerization interface [polypeptide binding]; other site 1183438000285 domain crossover interface; other site 1183438000286 redox-dependent activation switch; other site 1183438000287 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1183438000288 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1183438000289 catalytic residues [active] 1183438000290 catalytic nucleophile [active] 1183438000291 Presynaptic Site I dimer interface [polypeptide binding]; other site 1183438000292 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1183438000293 Synaptic Flat tetramer interface [polypeptide binding]; other site 1183438000294 Synaptic Site I dimer interface [polypeptide binding]; other site 1183438000295 DNA binding site [nucleotide binding] 1183438000296 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1183438000297 DNA-binding interface [nucleotide binding]; DNA binding site 1183438000298 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1183438000299 Integrase core domain; Region: rve; pfam00665 1183438000300 Integrase core domain; Region: rve_3; cl15866 1183438000301 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1183438000302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438000303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438000304 Walker A motif; other site 1183438000305 Walker A/P-loop; other site 1183438000306 ATP binding site [chemical binding]; other site 1183438000307 ATP binding site [chemical binding]; other site 1183438000308 Walker B motif; other site 1183438000309 arginine finger; other site 1183438000310 Hemerythrin family; Region: Hemerythrin-like; cl15774 1183438000311 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1183438000312 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1183438000313 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1183438000314 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1183438000315 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1183438000316 RPB1 interaction site [polypeptide binding]; other site 1183438000317 RPB10 interaction site [polypeptide binding]; other site 1183438000318 RPB11 interaction site [polypeptide binding]; other site 1183438000319 RPB3 interaction site [polypeptide binding]; other site 1183438000320 RPB12 interaction site [polypeptide binding]; other site 1183438000321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1183438000322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1183438000323 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1183438000324 putative effector binding pocket; other site 1183438000325 dimerization interface [polypeptide binding]; other site 1183438000326 short chain dehydrogenase; Validated; Region: PRK08264 1183438000327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438000328 NAD(P) binding site [chemical binding]; other site 1183438000329 active site 1183438000330 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1183438000331 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1183438000332 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 1183438000333 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1183438000334 NAD binding site [chemical binding]; other site 1183438000335 homotetramer interface [polypeptide binding]; other site 1183438000336 homodimer interface [polypeptide binding]; other site 1183438000337 substrate binding site [chemical binding]; other site 1183438000338 active site 1183438000339 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1183438000340 RimM N-terminal domain; Region: RimM; pfam01782 1183438000341 PRC-barrel domain; Region: PRC; pfam05239 1183438000342 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1183438000343 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1183438000344 homodimer interface [polypeptide binding]; other site 1183438000345 oligonucleotide binding site [chemical binding]; other site 1183438000346 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1183438000347 RNA/DNA hybrid binding site [nucleotide binding]; other site 1183438000348 active site 1183438000349 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1183438000350 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1183438000351 active site 1183438000352 dimer interface [polypeptide binding]; other site 1183438000353 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1183438000354 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1183438000355 active site 1183438000356 FMN binding site [chemical binding]; other site 1183438000357 substrate binding site [chemical binding]; other site 1183438000358 3Fe-4S cluster binding site [ion binding]; other site 1183438000359 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1183438000360 domain interface; other site 1183438000361 putative minor structural protein; Region: PHA01351 1183438000362 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 1183438000363 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1183438000364 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1183438000365 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1183438000366 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1183438000367 DNA binding residues [nucleotide binding] 1183438000368 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1183438000369 dimer interface [polypeptide binding]; other site 1183438000370 substrate binding site [chemical binding]; other site 1183438000371 ATP binding site [chemical binding]; other site 1183438000372 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 1183438000373 DNA polymerase III subunit delta'; Validated; Region: PRK07276 1183438000374 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1183438000375 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1183438000376 FAD binding domain; Region: FAD_binding_4; pfam01565 1183438000377 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1183438000378 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1183438000379 Cysteine-rich domain; Region: CCG; pfam02754 1183438000380 Cysteine-rich domain; Region: CCG; pfam02754 1183438000381 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1183438000382 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1183438000383 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1183438000384 TPP-binding site [chemical binding]; other site 1183438000385 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1183438000386 XFP C-terminal domain; Region: XFP_C; pfam09363 1183438000387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1183438000388 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438000389 putative active site [active] 1183438000390 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1183438000391 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1183438000392 PAS domain S-box; Region: sensory_box; TIGR00229 1183438000393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438000394 putative active site [active] 1183438000395 heme pocket [chemical binding]; other site 1183438000396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438000397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438000398 dimer interface [polypeptide binding]; other site 1183438000399 phosphorylation site [posttranslational modification] 1183438000400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438000401 ATP binding site [chemical binding]; other site 1183438000402 Mg2+ binding site [ion binding]; other site 1183438000403 G-X-G motif; other site 1183438000404 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1183438000405 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1183438000406 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1183438000407 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1183438000408 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438000409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438000410 active site 1183438000411 phosphorylation site [posttranslational modification] 1183438000412 intermolecular recognition site; other site 1183438000413 dimerization interface [polypeptide binding]; other site 1183438000414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438000415 dimerization interface [polypeptide binding]; other site 1183438000416 DNA binding residues [nucleotide binding] 1183438000417 Homeodomain-like domain; Region: HTH_23; pfam13384 1183438000418 Winged helix-turn helix; Region: HTH_29; pfam13551 1183438000419 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438000420 putative active site [active] 1183438000421 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 1183438000422 [2Fe-2S] cluster binding site [ion binding]; other site 1183438000423 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1183438000424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1183438000425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438000426 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1183438000427 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1183438000428 mercuric reductase; Validated; Region: PRK06370 1183438000429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438000430 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1183438000431 XamI restriction endonuclease; Region: RE_XamI; pfam09572 1183438000432 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1183438000433 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1183438000434 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1183438000435 Family of unknown function (DUF490); Region: DUF490; pfam04357 1183438000436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1183438000437 Histidine kinase; Region: HisKA_3; pfam07730 1183438000438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438000439 ATP binding site [chemical binding]; other site 1183438000440 Mg2+ binding site [ion binding]; other site 1183438000441 G-X-G motif; other site 1183438000442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438000443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438000444 active site 1183438000445 phosphorylation site [posttranslational modification] 1183438000446 intermolecular recognition site; other site 1183438000447 dimerization interface [polypeptide binding]; other site 1183438000448 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438000449 DNA binding residues [nucleotide binding] 1183438000450 dimerization interface [polypeptide binding]; other site 1183438000451 DNA polymerase I; Provisional; Region: PRK05755 1183438000452 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1183438000453 active site 1183438000454 metal binding site 1 [ion binding]; metal-binding site 1183438000455 putative 5' ssDNA interaction site; other site 1183438000456 metal binding site 3; metal-binding site 1183438000457 metal binding site 2 [ion binding]; metal-binding site 1183438000458 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1183438000459 putative DNA binding site [nucleotide binding]; other site 1183438000460 putative metal binding site [ion binding]; other site 1183438000461 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1183438000462 active site 1183438000463 catalytic site [active] 1183438000464 substrate binding site [chemical binding]; other site 1183438000465 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1183438000466 active site 1183438000467 DNA binding site [nucleotide binding] 1183438000468 catalytic site [active] 1183438000469 PIN domain; Region: PIN_3; pfam13470 1183438000470 hypothetical protein; frameshifted 1183438000471 DNA binding domain, excisionase family; Region: excise; TIGR01764 1183438000472 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1183438000473 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1183438000474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438000475 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 1183438000476 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1183438000477 active site 1183438000478 dimer interface [polypeptide binding]; other site 1183438000479 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1183438000480 dimer interface [polypeptide binding]; other site 1183438000481 active site 1183438000482 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1183438000483 DRTGG domain; Region: DRTGG; pfam07085 1183438000484 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438000485 putative active site [active] 1183438000486 TPR repeat; Region: TPR_11; pfam13414 1183438000487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000488 binding surface 1183438000489 TPR motif; other site 1183438000490 TPR repeat; Region: TPR_11; pfam13414 1183438000491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000492 binding surface 1183438000493 TPR motif; other site 1183438000494 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1183438000495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000496 binding surface 1183438000497 TPR motif; other site 1183438000498 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438000499 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1183438000500 Ferritin-like domain; Region: Ferritin; pfam00210 1183438000501 dimerization interface [polypeptide binding]; other site 1183438000502 DPS ferroxidase diiron center [ion binding]; other site 1183438000503 ion pore; other site 1183438000504 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1183438000505 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1183438000506 Walker A/P-loop; other site 1183438000507 ATP binding site [chemical binding]; other site 1183438000508 Q-loop/lid; other site 1183438000509 ABC transporter signature motif; other site 1183438000510 Walker B; other site 1183438000511 D-loop; other site 1183438000512 H-loop/switch region; other site 1183438000513 DevC protein; Region: devC; TIGR01185 1183438000514 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438000515 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1183438000516 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438000517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438000518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438000519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1183438000520 non-specific DNA binding site [nucleotide binding]; other site 1183438000521 salt bridge; other site 1183438000522 sequence-specific DNA binding site [nucleotide binding]; other site 1183438000523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000524 TPR repeat; Region: TPR_11; pfam13414 1183438000525 binding surface 1183438000526 TPR motif; other site 1183438000527 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1183438000528 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1183438000529 active site 1183438000530 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438000531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438000532 S-adenosylmethionine binding site [chemical binding]; other site 1183438000533 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438000534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438000535 S-adenosylmethionine binding site [chemical binding]; other site 1183438000536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438000537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438000538 S-adenosylmethionine binding site [chemical binding]; other site 1183438000539 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438000540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438000541 S-adenosylmethionine binding site [chemical binding]; other site 1183438000542 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1183438000543 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1183438000544 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1183438000545 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1183438000546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1183438000547 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1183438000548 acyl-activating enzyme (AAE) consensus motif; other site 1183438000549 acyl-activating enzyme (AAE) consensus motif; other site 1183438000550 putative AMP binding site [chemical binding]; other site 1183438000551 putative active site [active] 1183438000552 putative CoA binding site [chemical binding]; other site 1183438000553 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438000554 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1183438000555 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1183438000556 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1183438000557 Zn binding site [ion binding]; other site 1183438000558 PAS domain S-box; Region: sensory_box; TIGR00229 1183438000559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438000560 putative active site [active] 1183438000561 heme pocket [chemical binding]; other site 1183438000562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1183438000563 Histidine kinase; Region: HisKA_3; pfam07730 1183438000564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438000565 ATP binding site [chemical binding]; other site 1183438000566 Mg2+ binding site [ion binding]; other site 1183438000567 G-X-G motif; other site 1183438000568 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1183438000569 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1183438000570 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1183438000571 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1183438000572 catalytic site [active] 1183438000573 G-X2-G-X-G-K; other site 1183438000574 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1183438000575 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1183438000576 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1183438000577 putative active site [active] 1183438000578 Zn binding site [ion binding]; other site 1183438000579 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1183438000580 RNB domain; Region: RNB; pfam00773 1183438000581 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1183438000582 CpeS-like protein; Region: CpeS; pfam09367 1183438000583 PAAR motif; Region: PAAR_motif; pfam05488 1183438000584 PAAR motif; Region: PAAR_motif; pfam05488 1183438000585 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438000586 putative active site [active] 1183438000587 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 1183438000588 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1183438000589 RNA binding site [nucleotide binding]; other site 1183438000590 active site 1183438000591 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1183438000592 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 1183438000593 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1183438000594 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1183438000595 dimer interface [polypeptide binding]; other site 1183438000596 active site 1183438000597 CoA binding pocket [chemical binding]; other site 1183438000598 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1183438000599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1183438000600 Zn2+ binding site [ion binding]; other site 1183438000601 Mg2+ binding site [ion binding]; other site 1183438000602 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 1183438000603 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438000604 Predicted membrane protein [Function unknown]; Region: COG1289 1183438000605 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1183438000606 Divergent AAA domain; Region: AAA_4; pfam04326 1183438000607 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1183438000608 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1183438000609 Nuclease-related domain; Region: NERD; pfam08378 1183438000610 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1183438000611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1183438000612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1183438000613 endonuclease III; Region: ENDO3c; smart00478 1183438000614 minor groove reading motif; other site 1183438000615 helix-hairpin-helix signature motif; other site 1183438000616 substrate binding pocket [chemical binding]; other site 1183438000617 active site 1183438000618 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 1183438000619 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 1183438000620 ResB-like family; Region: ResB; pfam05140 1183438000621 cytochrome c biogenesis protein; Region: ccsA; CHL00045 1183438000622 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1183438000623 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1183438000624 Catalytic site [active] 1183438000625 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1183438000626 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1183438000627 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438000628 catalytic residue [active] 1183438000629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438000630 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1183438000631 active site 1183438000632 metal binding site [ion binding]; metal-binding site 1183438000633 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1183438000634 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1183438000635 HD domain; Region: HD_5; pfam13487 1183438000636 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438000637 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438000638 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438000639 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1183438000640 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1183438000641 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1183438000642 Probable Catalytic site; other site 1183438000643 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1183438000644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438000645 S-adenosylmethionine binding site [chemical binding]; other site 1183438000646 mercuric reductase; Validated; Region: PRK06370 1183438000647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1183438000648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438000649 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1183438000650 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1183438000651 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 1183438000652 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438000653 putative active site [active] 1183438000654 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1183438000655 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1183438000656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1183438000657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1183438000658 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1183438000659 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1183438000660 active site 1183438000661 dimer interface [polypeptide binding]; other site 1183438000662 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1183438000663 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1183438000664 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1183438000665 dimer interface [polypeptide binding]; other site 1183438000666 ssDNA binding site [nucleotide binding]; other site 1183438000667 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1183438000668 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1183438000669 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1183438000670 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1183438000671 acyl-activating enzyme (AAE) consensus motif; other site 1183438000672 putative AMP binding site [chemical binding]; other site 1183438000673 putative active site [active] 1183438000674 putative CoA binding site [chemical binding]; other site 1183438000675 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1183438000676 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 1183438000677 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1183438000678 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1183438000679 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1183438000680 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1183438000681 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1183438000682 Substrate binding site; other site 1183438000683 Mg++ binding site; other site 1183438000684 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1183438000685 active site 1183438000686 substrate binding site [chemical binding]; other site 1183438000687 CoA binding site [chemical binding]; other site 1183438000688 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1183438000689 PBP superfamily domain; Region: PBP_like_2; cl17296 1183438000690 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1183438000691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438000692 dimer interface [polypeptide binding]; other site 1183438000693 conserved gate region; other site 1183438000694 putative PBP binding loops; other site 1183438000695 ABC-ATPase subunit interface; other site 1183438000696 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1183438000697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438000698 dimer interface [polypeptide binding]; other site 1183438000699 conserved gate region; other site 1183438000700 putative PBP binding loops; other site 1183438000701 ABC-ATPase subunit interface; other site 1183438000702 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1183438000703 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1183438000704 Walker A/P-loop; other site 1183438000705 ATP binding site [chemical binding]; other site 1183438000706 Q-loop/lid; other site 1183438000707 ABC transporter signature motif; other site 1183438000708 Walker B; other site 1183438000709 D-loop; other site 1183438000710 H-loop/switch region; other site 1183438000711 tyrosine recombinase XerD; truncated 1183438000712 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1183438000713 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1183438000714 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1183438000715 Chain length determinant protein; Region: Wzz; cl15801 1183438000716 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1183438000717 AAA domain; Region: AAA_31; pfam13614 1183438000718 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1183438000719 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1183438000720 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438000721 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1183438000722 active site 1183438000723 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1183438000724 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1183438000725 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1183438000726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438000727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438000728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438000729 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438000730 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438000731 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1183438000732 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1183438000733 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1183438000734 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1183438000735 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1183438000736 active site 1183438000737 Substrate binding site; other site 1183438000738 Mg++ binding site; other site 1183438000739 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438000740 colanic acid exporter; Provisional; Region: PRK10459 1183438000741 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1183438000742 UDP-N-acetylenolpyruvoylglucosamine reductase; Region: murB; TIGR00179 1183438000743 FAD binding domain; Region: FAD_binding_4; pfam01565 1183438000744 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1183438000745 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1183438000746 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1183438000747 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1183438000748 trimer interface [polypeptide binding]; other site 1183438000749 active site 1183438000750 substrate binding site [chemical binding]; other site 1183438000751 CoA binding site [chemical binding]; other site 1183438000752 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438000753 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1183438000754 GDP-mannose 4,6-dehydratase; Region: PLN02653 1183438000755 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1183438000756 NADP-binding site; other site 1183438000757 homotetramer interface [polypeptide binding]; other site 1183438000758 substrate binding site [chemical binding]; other site 1183438000759 homodimer interface [polypeptide binding]; other site 1183438000760 active site 1183438000761 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1183438000762 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1183438000763 NADP binding site [chemical binding]; other site 1183438000764 active site 1183438000765 putative substrate binding site [chemical binding]; other site 1183438000766 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1183438000767 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1183438000768 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 1183438000769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438000770 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1183438000771 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1183438000772 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1183438000773 hexamer interface [polypeptide binding]; other site 1183438000774 ligand binding site [chemical binding]; other site 1183438000775 putative active site [active] 1183438000776 NAD(P) binding site [chemical binding]; other site 1183438000777 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1183438000778 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1183438000779 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1183438000780 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1183438000781 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1183438000782 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1183438000783 dinuclear metal binding motif [ion binding]; other site 1183438000784 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1183438000785 manganese transport protein MntH; Reviewed; Region: PRK00701 1183438000786 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1183438000787 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1183438000788 putative hydrophobic ligand binding site [chemical binding]; other site 1183438000789 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1183438000790 active site residue [active] 1183438000791 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1183438000792 nudix motif; other site 1183438000793 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1183438000794 dimer interface [polypeptide binding]; other site 1183438000795 ADP-ribose binding site [chemical binding]; other site 1183438000796 active site 1183438000797 nudix motif; other site 1183438000798 metal binding site [ion binding]; metal-binding site 1183438000799 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438000800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438000801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438000802 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438000803 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1183438000804 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1183438000805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438000806 Walker A motif; other site 1183438000807 ATP binding site [chemical binding]; other site 1183438000808 Walker B motif; other site 1183438000809 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1183438000810 trigger factor; Provisional; Region: tig; PRK01490 1183438000811 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1183438000812 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1183438000813 GrpE; Region: GrpE; pfam01025 1183438000814 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1183438000815 dimer interface [polypeptide binding]; other site 1183438000816 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1183438000817 phosphoglycolate phosphatase, TA0175-type; Region: Pglycolate_arch; TIGR01487 1183438000818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438000819 active site 1183438000820 motif I; other site 1183438000821 motif II; other site 1183438000822 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1183438000823 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1183438000824 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 1183438000825 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 1183438000826 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1183438000827 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1183438000828 iron-sulfur cluster [ion binding]; other site 1183438000829 [2Fe-2S] cluster binding site [ion binding]; other site 1183438000830 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1183438000831 Ligand Binding Site [chemical binding]; other site 1183438000832 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1183438000833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438000834 FeS/SAM binding site; other site 1183438000835 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1183438000836 CheB methylesterase; Region: CheB_methylest; pfam01339 1183438000837 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1183438000838 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1183438000839 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1183438000840 PAS domain; Region: PAS_10; pfam13596 1183438000841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438000842 putative active site [active] 1183438000843 heme pocket [chemical binding]; other site 1183438000844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438000845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438000846 dimer interface [polypeptide binding]; other site 1183438000847 phosphorylation site [posttranslational modification] 1183438000848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438000849 ATP binding site [chemical binding]; other site 1183438000850 Mg2+ binding site [ion binding]; other site 1183438000851 G-X-G motif; other site 1183438000852 hypothetical protein; Provisional; Region: PRK07394 1183438000853 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1183438000854 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1183438000855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1183438000856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1183438000857 dimerization interface [polypeptide binding]; other site 1183438000858 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1183438000859 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1183438000860 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1183438000861 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1183438000862 argininosuccinate synthase; Provisional; Region: PRK13820 1183438000863 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1183438000864 ANP binding site [chemical binding]; other site 1183438000865 Substrate Binding Site II [chemical binding]; other site 1183438000866 Substrate Binding Site I [chemical binding]; other site 1183438000867 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 1183438000868 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 1183438000869 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1183438000870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438000871 dimer interface [polypeptide binding]; other site 1183438000872 conserved gate region; other site 1183438000873 putative PBP binding loops; other site 1183438000874 ABC-ATPase subunit interface; other site 1183438000875 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1183438000876 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 1183438000877 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1183438000878 dimerization interface [polypeptide binding]; other site 1183438000879 active site 1183438000880 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438000881 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438000882 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1183438000883 homooctamer interface [polypeptide binding]; other site 1183438000884 active site 1183438000885 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1183438000886 Ferredoxin [Energy production and conversion]; Region: COG1146 1183438000887 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1183438000888 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1183438000889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438000890 S-adenosylmethionine binding site [chemical binding]; other site 1183438000891 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1183438000892 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1183438000893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438000894 Walker A/P-loop; other site 1183438000895 ATP binding site [chemical binding]; other site 1183438000896 Q-loop/lid; other site 1183438000897 ABC transporter signature motif; other site 1183438000898 Walker B; other site 1183438000899 D-loop; other site 1183438000900 H-loop/switch region; other site 1183438000901 Domain of unknown function DUF39; Region: DUF39; pfam01837 1183438000902 PBP superfamily domain; Region: PBP_like_2; pfam12849 1183438000903 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1183438000904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438000905 dimerization interface [polypeptide binding]; other site 1183438000906 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1183438000907 homotrimer interaction site [polypeptide binding]; other site 1183438000908 putative active site [active] 1183438000909 Protein of unknown function (DUF561); Region: DUF561; pfam04481 1183438000910 Bacterial SH3 domain; Region: SH3_3; cl17532 1183438000911 NlpC/P60 family; Region: NLPC_P60; cl17555 1183438000912 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1183438000913 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1183438000914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438000915 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1183438000916 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1183438000917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000918 TPR motif; other site 1183438000919 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438000920 binding surface 1183438000921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438000922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000923 binding surface 1183438000924 TPR motif; other site 1183438000925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438000926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438000927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000928 binding surface 1183438000929 TPR motif; other site 1183438000930 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438000931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438000932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438000933 binding surface 1183438000934 TPR motif; other site 1183438000935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438000936 CHAT domain; Region: CHAT; pfam12770 1183438000937 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1183438000938 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 1183438000939 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1183438000940 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1183438000941 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1183438000942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438000943 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1183438000944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438000945 DNA binding residues [nucleotide binding] 1183438000946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438000947 non-specific DNA binding site [nucleotide binding]; other site 1183438000948 salt bridge; other site 1183438000949 sequence-specific DNA binding site [nucleotide binding]; other site 1183438000950 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1183438000951 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 1183438000952 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1183438000953 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438000954 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438000955 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438000956 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438000957 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1183438000958 putative active site [active] 1183438000959 transaldolase; Provisional; Region: PRK03903 1183438000960 catalytic residue [active] 1183438000961 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1183438000962 trimer interface [polypeptide binding]; other site 1183438000963 dimer interface [polypeptide binding]; other site 1183438000964 putative active site [active] 1183438000965 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 1183438000966 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1183438000967 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1183438000968 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1183438000969 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1183438000970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438000971 Coenzyme A binding pocket [chemical binding]; other site 1183438000972 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1183438000973 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1183438000974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1183438000975 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1183438000976 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1183438000977 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438000978 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1183438000979 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1183438000980 catalytic triad [active] 1183438000981 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1183438000982 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1183438000983 Tetramer interface [polypeptide binding]; other site 1183438000984 active site 1183438000985 FMN-binding site [chemical binding]; other site 1183438000986 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1183438000987 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438000988 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1183438000989 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1183438000990 Walker A/P-loop; other site 1183438000991 ATP binding site [chemical binding]; other site 1183438000992 Q-loop/lid; other site 1183438000993 ABC transporter signature motif; other site 1183438000994 Walker B; other site 1183438000995 D-loop; other site 1183438000996 H-loop/switch region; other site 1183438000997 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1183438000998 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1183438000999 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1183438001000 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1183438001001 active site 1183438001002 Int/Topo IB signature motif; other site 1183438001003 catalytic residues [active] 1183438001004 DNA binding site [nucleotide binding] 1183438001005 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1183438001006 active site 1183438001007 metal binding site [ion binding]; metal-binding site 1183438001008 AAA domain; Region: AAA_25; pfam13481 1183438001009 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1183438001010 Walker A motif; other site 1183438001011 ATP binding site [chemical binding]; other site 1183438001012 Walker B motif; other site 1183438001013 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1183438001014 Terminase-like family; Region: Terminase_6; pfam03237 1183438001015 Phage terminase large subunit; Region: Terminase_3; cl12054 1183438001016 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1183438001017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1183438001018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438001019 non-specific DNA binding site [nucleotide binding]; other site 1183438001020 salt bridge; other site 1183438001021 sequence-specific DNA binding site [nucleotide binding]; other site 1183438001022 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1183438001023 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438001024 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438001025 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438001026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438001027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438001028 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1183438001029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438001030 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1183438001031 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1183438001032 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1183438001033 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1183438001034 hypothetical protein; Validated; Region: PRK00029 1183438001035 Cupin domain; Region: Cupin_2; cl17218 1183438001036 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1183438001037 trimer interface [polypeptide binding]; other site 1183438001038 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1183438001039 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1183438001040 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1183438001041 N-terminal plug; other site 1183438001042 ligand-binding site [chemical binding]; other site 1183438001043 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438001044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438001045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438001046 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438001047 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1183438001048 rod shape-determining protein MreC; Provisional; Region: PRK13922 1183438001049 rod shape-determining protein MreC; Region: MreC; pfam04085 1183438001050 rod shape-determining protein MreB; Provisional; Region: PRK13927 1183438001051 MreB and similar proteins; Region: MreB_like; cd10225 1183438001052 nucleotide binding site [chemical binding]; other site 1183438001053 Mg binding site [ion binding]; other site 1183438001054 putative protofilament interaction site [polypeptide binding]; other site 1183438001055 RodZ interaction site [polypeptide binding]; other site 1183438001056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438001057 non-specific DNA binding site [nucleotide binding]; other site 1183438001058 salt bridge; other site 1183438001059 sequence-specific DNA binding site [nucleotide binding]; other site 1183438001060 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1183438001061 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1183438001062 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1183438001063 RNA binding surface [nucleotide binding]; other site 1183438001064 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1183438001065 active site 1183438001066 Repair protein; Region: Repair_PSII; pfam04536 1183438001067 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 1183438001068 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1183438001069 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1183438001070 dimer interface [polypeptide binding]; other site 1183438001071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438001072 ligand binding site [chemical binding]; other site 1183438001073 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 1183438001074 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1183438001075 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1183438001076 active site 1183438001077 multimer interface [polypeptide binding]; other site 1183438001078 Helix-turn-helix domain; Region: HTH_36; pfam13730 1183438001079 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1183438001080 Catalytic site [active] 1183438001081 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1183438001082 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1183438001083 TonB C terminal; Region: TonB_2; pfam13103 1183438001084 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1183438001085 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1183438001086 catalytic residues [active] 1183438001087 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438001088 catalytic motif [active] 1183438001089 Catalytic residue [active] 1183438001090 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1183438001091 Restriction endonuclease NotI; Region: NotI; pfam12183 1183438001092 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1183438001093 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1183438001094 PA/protease or protease-like domain interface [polypeptide binding]; other site 1183438001095 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 1183438001096 Peptidase family M28; Region: Peptidase_M28; pfam04389 1183438001097 metal binding site [ion binding]; metal-binding site 1183438001098 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1183438001099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438001100 active site 1183438001101 phosphorylation site [posttranslational modification] 1183438001102 intermolecular recognition site; other site 1183438001103 dimerization interface [polypeptide binding]; other site 1183438001104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438001105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438001106 dimer interface [polypeptide binding]; other site 1183438001107 phosphorylation site [posttranslational modification] 1183438001108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438001109 ATP binding site [chemical binding]; other site 1183438001110 Mg2+ binding site [ion binding]; other site 1183438001111 G-X-G motif; other site 1183438001112 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438001113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438001114 active site 1183438001115 phosphorylation site [posttranslational modification] 1183438001116 intermolecular recognition site; other site 1183438001117 dimerization interface [polypeptide binding]; other site 1183438001118 CHASE3 domain; Region: CHASE3; pfam05227 1183438001119 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1183438001120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438001121 putative active site [active] 1183438001122 heme pocket [chemical binding]; other site 1183438001123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438001124 dimer interface [polypeptide binding]; other site 1183438001125 phosphorylation site [posttranslational modification] 1183438001126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438001127 ATP binding site [chemical binding]; other site 1183438001128 Mg2+ binding site [ion binding]; other site 1183438001129 G-X-G motif; other site 1183438001130 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1183438001131 putative active site pocket [active] 1183438001132 dimerization interface [polypeptide binding]; other site 1183438001133 putative catalytic residue [active] 1183438001134 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1183438001135 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438001136 Fic family protein [Function unknown]; Region: COG3177 1183438001137 Fic/DOC family; Region: Fic; pfam02661 1183438001138 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1183438001139 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 1183438001140 UbiA prenyltransferase family; Region: UbiA; pfam01040 1183438001141 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1183438001142 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1183438001143 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1183438001144 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1183438001145 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1183438001146 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1183438001147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438001148 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1183438001149 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438001150 active site 1183438001151 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1183438001152 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1183438001153 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1183438001154 Chain length determinant protein; Region: Wzz; cl15801 1183438001155 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1183438001156 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1183438001157 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1183438001158 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1183438001159 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1183438001160 trimer interface [polypeptide binding]; other site 1183438001161 active site 1183438001162 substrate binding site [chemical binding]; other site 1183438001163 CoA binding site [chemical binding]; other site 1183438001164 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 1183438001165 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1183438001166 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438001167 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438001168 active site 1183438001169 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438001170 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1183438001171 putative ADP-binding pocket [chemical binding]; other site 1183438001172 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1183438001173 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1183438001174 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1183438001175 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1183438001176 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1183438001177 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1183438001178 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1183438001179 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1183438001180 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1183438001181 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1183438001182 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1183438001183 inhibitor-cofactor binding pocket; inhibition site 1183438001184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438001185 catalytic residue [active] 1183438001186 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1183438001187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438001188 NAD(P) binding site [chemical binding]; other site 1183438001189 active site 1183438001190 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438001191 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438001192 active site 1183438001193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438001194 hypothetical protein; Provisional; Region: PRK07233 1183438001195 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1183438001196 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1183438001197 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1183438001198 Ligand binding site; other site 1183438001199 Putative Catalytic site; other site 1183438001200 DXD motif; other site 1183438001201 Predicted membrane protein [Function unknown]; Region: COG2246 1183438001202 GtrA-like protein; Region: GtrA; pfam04138 1183438001203 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438001204 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1183438001205 active site 1183438001206 G8 domain; Region: G8; pfam10162 1183438001207 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1183438001208 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438001209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438001210 S-adenosylmethionine binding site [chemical binding]; other site 1183438001211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1183438001212 Probable transposase; Region: OrfB_IS605; pfam01385 1183438001213 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1183438001214 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1183438001215 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1183438001216 putative trimer interface [polypeptide binding]; other site 1183438001217 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 1183438001218 putative CoA binding site [chemical binding]; other site 1183438001219 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1183438001220 putative trimer interface [polypeptide binding]; other site 1183438001221 putative active site [active] 1183438001222 putative substrate binding site [chemical binding]; other site 1183438001223 putative CoA binding site [chemical binding]; other site 1183438001224 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1183438001225 active site 1183438001226 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1183438001227 homodimer interface [polypeptide binding]; other site 1183438001228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438001229 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1183438001230 NAD(P) binding site [chemical binding]; other site 1183438001231 active site 1183438001232 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 1183438001233 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1183438001234 active site 1183438001235 Substrate binding site; other site 1183438001236 Mg++ binding site; other site 1183438001237 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438001238 putative trimer interface [polypeptide binding]; other site 1183438001239 putative CoA binding site [chemical binding]; other site 1183438001240 PsaD; Region: PsaD; pfam02531 1183438001241 PetN; Region: PetN; cl15376 1183438001242 CP12 domain; Region: CP12; pfam02672 1183438001243 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1183438001244 putative active site; other site 1183438001245 putative metal binding residues [ion binding]; other site 1183438001246 signature motif; other site 1183438001247 putative triphosphate binding site [ion binding]; other site 1183438001248 membrane protein P6; Region: PHA01399 1183438001249 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1183438001250 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1183438001251 homodimer interface [polypeptide binding]; other site 1183438001252 substrate-cofactor binding pocket; other site 1183438001253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438001254 catalytic residue [active] 1183438001255 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1183438001256 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1183438001257 putative NAD(P) binding site [chemical binding]; other site 1183438001258 putative substrate binding site [chemical binding]; other site 1183438001259 catalytic Zn binding site [ion binding]; other site 1183438001260 structural Zn binding site [ion binding]; other site 1183438001261 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1183438001262 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1183438001263 active site 1183438001264 Zn binding site [ion binding]; other site 1183438001265 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1183438001266 active site 1183438001267 iron coordination sites [ion binding]; other site 1183438001268 substrate binding pocket [chemical binding]; other site 1183438001269 TPR repeat; Region: TPR_11; pfam13414 1183438001270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001271 binding surface 1183438001272 TPR motif; other site 1183438001273 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1183438001274 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1183438001275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001276 binding surface 1183438001277 TPR motif; other site 1183438001278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001279 TPR motif; other site 1183438001280 binding surface 1183438001281 Sulfatase; Region: Sulfatase; cl17466 1183438001282 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438001283 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438001284 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438001285 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1183438001286 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1183438001287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438001288 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1183438001289 peptidase domain interface [polypeptide binding]; other site 1183438001290 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1183438001291 active site 1183438001292 catalytic triad [active] 1183438001293 calcium binding site [ion binding]; other site 1183438001294 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1183438001295 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1183438001296 RNA binding surface [nucleotide binding]; other site 1183438001297 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1183438001298 active site 1183438001299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001300 binding surface 1183438001301 TPR motif; other site 1183438001302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001304 binding surface 1183438001305 TPR motif; other site 1183438001306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001307 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001310 binding surface 1183438001311 TPR motif; other site 1183438001312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001314 binding surface 1183438001315 TPR motif; other site 1183438001316 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001317 CHAT domain; Region: CHAT; pfam12770 1183438001318 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1183438001319 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1183438001320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438001321 motif II; other site 1183438001322 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438001323 putative active site [active] 1183438001324 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438001325 putative active site [active] 1183438001326 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 1183438001327 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1183438001328 dimer interface [polypeptide binding]; other site 1183438001329 active site 1183438001330 Schiff base residues; other site 1183438001331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438001332 S-adenosylmethionine binding site [chemical binding]; other site 1183438001333 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1183438001334 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1183438001335 N-terminal plug; other site 1183438001336 ligand-binding site [chemical binding]; other site 1183438001337 putative high light inducible protein; Region: PHA02337 1183438001338 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1183438001339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438001340 NAD(P) binding site [chemical binding]; other site 1183438001341 active site 1183438001342 AAA ATPase domain; Region: AAA_16; pfam13191 1183438001343 NACHT domain; Region: NACHT; pfam05729 1183438001344 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438001345 WD40 repeats; Region: WD40; smart00320 1183438001346 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438001347 structural tetrad; other site 1183438001348 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438001349 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438001350 structural tetrad; other site 1183438001351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001352 binding surface 1183438001353 TPR motif; other site 1183438001354 TPR repeat; Region: TPR_11; pfam13414 1183438001355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001356 binding surface 1183438001357 TPR motif; other site 1183438001358 TPR repeat; Region: TPR_11; pfam13414 1183438001359 TIGR03118 family protein; Region: PEPCTERM_chp_1 1183438001360 Protein of unknown function DUF45; Region: DUF45; pfam01863 1183438001361 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1183438001362 RibD C-terminal domain; Region: RibD_C; cl17279 1183438001363 Predicted membrane protein [Function unknown]; Region: COG2246 1183438001364 GtrA-like protein; Region: GtrA; pfam04138 1183438001365 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1183438001366 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1183438001367 lipoyl attachment site [posttranslational modification]; other site 1183438001368 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1183438001369 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1183438001370 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1183438001371 hypothetical protein; Provisional; Region: PRK08912 1183438001372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1183438001373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438001374 homodimer interface [polypeptide binding]; other site 1183438001375 catalytic residue [active] 1183438001376 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1183438001377 chaperone protein DnaJ; Provisional; Region: PRK14299 1183438001378 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1183438001379 HSP70 interaction site [polypeptide binding]; other site 1183438001380 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1183438001381 substrate binding site [polypeptide binding]; other site 1183438001382 dimer interface [polypeptide binding]; other site 1183438001383 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1183438001384 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1183438001385 putative active site [active] 1183438001386 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 1183438001387 FAD binding pocket [chemical binding]; other site 1183438001388 conserved FAD binding motif [chemical binding]; other site 1183438001389 phosphate binding motif [ion binding]; other site 1183438001390 beta-alpha-beta structure motif; other site 1183438001391 NAD binding pocket [chemical binding]; other site 1183438001392 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1183438001393 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 1183438001394 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1183438001395 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 1183438001396 putative active site [active] 1183438001397 catalytic site [active] 1183438001398 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438001399 putative active site [active] 1183438001400 TPR repeat; Region: TPR_11; pfam13414 1183438001401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001402 binding surface 1183438001403 TPR motif; other site 1183438001404 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1183438001405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001406 binding surface 1183438001407 TPR motif; other site 1183438001408 TPR repeat; Region: TPR_11; pfam13414 1183438001409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001410 TPR motif; other site 1183438001411 binding surface 1183438001412 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438001413 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1183438001414 PBP superfamily domain; Region: PBP_like_2; cl17296 1183438001415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001416 TPR motif; other site 1183438001417 TPR repeat; Region: TPR_11; pfam13414 1183438001418 binding surface 1183438001419 TPR repeat; Region: TPR_11; pfam13414 1183438001420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001421 binding surface 1183438001422 TPR motif; other site 1183438001423 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1183438001424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001425 binding surface 1183438001426 TPR motif; other site 1183438001427 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438001428 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1183438001429 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1183438001430 tRNA; other site 1183438001431 putative tRNA binding site [nucleotide binding]; other site 1183438001432 putative NADP binding site [chemical binding]; other site 1183438001433 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1183438001434 hydrolase, alpha/beta fold family protein; Region: PLN02824 1183438001435 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1183438001436 AMIN domain; Region: AMIN; pfam11741 1183438001437 AMIN domain; Region: AMIN; pfam11741 1183438001438 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1183438001439 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1183438001440 active site 1183438001441 metal binding site [ion binding]; metal-binding site 1183438001442 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1183438001443 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1183438001444 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1183438001445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1183438001446 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1183438001447 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1183438001448 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438001449 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438001450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438001451 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438001452 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1183438001453 active site 1183438001454 substrate binding site [chemical binding]; other site 1183438001455 catalytic site [active] 1183438001456 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1183438001457 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1183438001458 active site lid residues [active] 1183438001459 substrate binding pocket [chemical binding]; other site 1183438001460 catalytic residues [active] 1183438001461 substrate-Mg2+ binding site; other site 1183438001462 aspartate-rich region 1; other site 1183438001463 aspartate-rich region 2; other site 1183438001464 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 1183438001465 Zinc finger domain; Region: ZnF_RBZ; smart00547 1183438001466 Double zinc ribbon; Region: DZR; pfam12773 1183438001467 PBP superfamily domain; Region: PBP_like_2; cl17296 1183438001468 Tubulin like; Region: Tubulin_2; pfam13809 1183438001469 HEAT repeats; Region: HEAT_2; pfam13646 1183438001470 HEAT repeats; Region: HEAT_2; pfam13646 1183438001471 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1183438001472 HEAT repeats; Region: HEAT_2; pfam13646 1183438001473 protein binding surface [polypeptide binding]; other site 1183438001474 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1183438001475 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 1183438001476 Ligand binding site; other site 1183438001477 DXD motif; other site 1183438001478 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1183438001479 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1183438001480 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438001481 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1183438001482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438001483 active site 1183438001484 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1183438001485 HD domain; Region: HD_4; pfam13328 1183438001486 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1183438001487 synthetase active site [active] 1183438001488 NTP binding site [chemical binding]; other site 1183438001489 metal binding site [ion binding]; metal-binding site 1183438001490 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1183438001491 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1183438001492 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1183438001493 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1183438001494 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1183438001495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1183438001496 binding surface 1183438001497 TPR motif; other site 1183438001498 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1183438001499 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1183438001500 Proline dehydrogenase; Region: Pro_dh; pfam01619 1183438001501 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1183438001502 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1183438001503 Glutamate binding site [chemical binding]; other site 1183438001504 homodimer interface [polypeptide binding]; other site 1183438001505 NAD binding site [chemical binding]; other site 1183438001506 catalytic residues [active] 1183438001507 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 1183438001508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438001509 FeS/SAM binding site; other site 1183438001510 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 1183438001511 Predicted transcriptional regulators [Transcription]; Region: COG1725 1183438001512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1183438001513 DNA-binding site [nucleotide binding]; DNA binding site 1183438001514 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001516 binding surface 1183438001517 TPR motif; other site 1183438001518 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001519 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001520 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1183438001521 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001523 binding surface 1183438001524 TPR motif; other site 1183438001525 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001526 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438001528 CHAT domain; Region: CHAT; pfam12770 1183438001529 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1183438001530 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1183438001531 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1183438001532 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 1183438001533 alanine racemase; Reviewed; Region: alr; PRK00053 1183438001534 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1183438001535 active site 1183438001536 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1183438001537 dimer interface [polypeptide binding]; other site 1183438001538 substrate binding site [chemical binding]; other site 1183438001539 catalytic residues [active] 1183438001540 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1183438001541 elongation factor G; Reviewed; Region: PRK12740 1183438001542 G1 box; other site 1183438001543 putative GEF interaction site [polypeptide binding]; other site 1183438001544 GTP/Mg2+ binding site [chemical binding]; other site 1183438001545 Switch I region; other site 1183438001546 G2 box; other site 1183438001547 G3 box; other site 1183438001548 Switch II region; other site 1183438001549 G4 box; other site 1183438001550 G5 box; other site 1183438001551 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1183438001552 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1183438001553 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1183438001554 PAS fold; Region: PAS; pfam00989 1183438001555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438001556 putative active site [active] 1183438001557 heme pocket [chemical binding]; other site 1183438001558 PAS fold; Region: PAS_4; pfam08448 1183438001559 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1183438001560 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1183438001561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1183438001562 Histidine kinase; Region: HisKA_3; pfam07730 1183438001563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438001564 ATP binding site [chemical binding]; other site 1183438001565 Mg2+ binding site [ion binding]; other site 1183438001566 G-X-G motif; other site 1183438001567 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1183438001568 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1183438001569 NAD(P) binding site [chemical binding]; other site 1183438001570 putative active site [active] 1183438001571 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1183438001572 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1183438001573 dimerization interface [polypeptide binding]; other site 1183438001574 DPS ferroxidase diiron center [ion binding]; other site 1183438001575 ion pore; other site 1183438001576 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1183438001577 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1183438001578 homodimer interface [polypeptide binding]; other site 1183438001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438001580 catalytic residue [active] 1183438001581 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1183438001582 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1183438001583 Sm and related proteins; Region: Sm_like; cl00259 1183438001584 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1183438001585 putative oligomer interface [polypeptide binding]; other site 1183438001586 putative RNA binding site [nucleotide binding]; other site 1183438001587 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1183438001588 NusA N-terminal domain; Region: NusA_N; pfam08529 1183438001589 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1183438001590 RNA binding site [nucleotide binding]; other site 1183438001591 homodimer interface [polypeptide binding]; other site 1183438001592 NusA-like KH domain; Region: KH_5; pfam13184 1183438001593 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1183438001594 G-X-X-G motif; other site 1183438001595 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1183438001596 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1183438001597 DNA binding site [nucleotide binding] 1183438001598 substrate interaction site [chemical binding]; other site 1183438001599 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1183438001600 Z1 domain; Region: Z1; pfam10593 1183438001601 Putative addiction module component; Region: Unstab_antitox; pfam09720 1183438001602 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1183438001603 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1183438001604 generic binding surface II; other site 1183438001605 generic binding surface I; other site 1183438001606 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1183438001607 putative catalytic site [active] 1183438001608 putative metal binding site [ion binding]; other site 1183438001609 putative phosphate binding site [ion binding]; other site 1183438001610 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438001611 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1183438001612 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1183438001613 5S rRNA interface [nucleotide binding]; other site 1183438001614 CTC domain interface [polypeptide binding]; other site 1183438001615 L16 interface [polypeptide binding]; other site 1183438001616 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438001617 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438001618 agmatinase; Region: agmatinase; TIGR01230 1183438001619 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1183438001620 active site 1183438001621 metal binding site [ion binding]; metal-binding site 1183438001622 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1183438001623 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1183438001624 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1183438001625 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438001626 active site 1183438001627 metal binding site [ion binding]; metal-binding site 1183438001628 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1183438001629 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1183438001630 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1183438001631 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1183438001632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1183438001633 Integrase core domain; Region: rve; pfam00665 1183438001634 Integrase core domain; Region: rve_3; pfam13683 1183438001635 Transposase; Region: HTH_Tnp_1; pfam01527 1183438001636 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1183438001637 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1183438001638 active site 1183438001639 dimer interface [polypeptide binding]; other site 1183438001640 light-harvesting-like protein 3; Provisional; Region: PLN00014 1183438001641 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1183438001642 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1183438001643 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1183438001644 trimer interface [polypeptide binding]; other site 1183438001645 active site 1183438001646 UDP-GlcNAc binding site [chemical binding]; other site 1183438001647 lipid binding site [chemical binding]; lipid-binding site 1183438001648 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1183438001649 shikimate kinase; Reviewed; Region: aroK; PRK00131 1183438001650 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1183438001651 ADP binding site [chemical binding]; other site 1183438001652 magnesium binding site [ion binding]; other site 1183438001653 putative shikimate binding site; other site 1183438001654 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1183438001655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1183438001656 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1183438001657 substrate binding pocket [chemical binding]; other site 1183438001658 membrane-bound complex binding site; other site 1183438001659 hinge residues; other site 1183438001660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438001661 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438001662 active site 1183438001663 phosphorylation site [posttranslational modification] 1183438001664 intermolecular recognition site; other site 1183438001665 dimerization interface [polypeptide binding]; other site 1183438001666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438001667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438001668 ATP binding site [chemical binding]; other site 1183438001669 Mg2+ binding site [ion binding]; other site 1183438001670 G-X-G motif; other site 1183438001671 PAS domain S-box; Region: sensory_box; TIGR00229 1183438001672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438001673 putative active site [active] 1183438001674 heme pocket [chemical binding]; other site 1183438001675 PAS domain; Region: PAS_9; pfam13426 1183438001676 PAS fold; Region: PAS_4; pfam08448 1183438001677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438001678 putative active site [active] 1183438001679 heme pocket [chemical binding]; other site 1183438001680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1183438001681 Histidine kinase; Region: HisKA_2; pfam07568 1183438001682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438001683 Mg2+ binding site [ion binding]; other site 1183438001684 G-X-G motif; other site 1183438001685 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1183438001686 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1183438001687 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1183438001688 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1183438001689 putative substrate binding region [chemical binding]; other site 1183438001690 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1183438001691 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1183438001692 putative NAD(P) binding site [chemical binding]; other site 1183438001693 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1183438001694 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1183438001695 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1183438001696 dimer interface [polypeptide binding]; other site 1183438001697 motif 1; other site 1183438001698 active site 1183438001699 motif 2; other site 1183438001700 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1183438001701 putative deacylase active site [active] 1183438001702 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1183438001703 active site 1183438001704 motif 3; other site 1183438001705 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1183438001706 anticodon binding site; other site 1183438001707 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1183438001708 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 1183438001709 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1183438001710 dimer interface [polypeptide binding]; other site 1183438001711 active site 1183438001712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1183438001713 YcfA-like protein; Region: YcfA; pfam07927 1183438001714 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1183438001715 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1183438001716 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1183438001717 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1183438001718 putative dimer interface [polypeptide binding]; other site 1183438001719 N-terminal domain interface [polypeptide binding]; other site 1183438001720 putative substrate binding pocket (H-site) [chemical binding]; other site 1183438001721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438001722 TPR motif; other site 1183438001723 binding surface 1183438001724 TPR repeat; Region: TPR_11; pfam13414 1183438001725 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1183438001726 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1183438001727 Active Sites [active] 1183438001728 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 1183438001729 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1183438001730 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1183438001731 active site 1183438001732 hydrophilic channel; other site 1183438001733 dimerization interface [polypeptide binding]; other site 1183438001734 catalytic residues [active] 1183438001735 active site lid [active] 1183438001736 Predicted membrane protein [Function unknown]; Region: COG2261 1183438001737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438001738 Coenzyme A binding pocket [chemical binding]; other site 1183438001739 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 1183438001740 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1183438001741 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1183438001742 Hexamer interface [polypeptide binding]; other site 1183438001743 Hexagonal pore residue; other site 1183438001744 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1183438001745 Hexamer interface [polypeptide binding]; other site 1183438001746 Hexagonal pore residue; other site 1183438001747 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1183438001748 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1183438001749 trimer interface [polypeptide binding]; other site 1183438001750 active site 1183438001751 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1183438001752 putative multimerization interface [polypeptide binding]; other site 1183438001753 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1183438001754 putative multimerization interface [polypeptide binding]; other site 1183438001755 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1183438001756 putative multimerization interface [polypeptide binding]; other site 1183438001757 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1183438001758 putative multimerization interface [polypeptide binding]; other site 1183438001759 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1183438001760 Hexamer/Pentamer interface [polypeptide binding]; other site 1183438001761 central pore; other site 1183438001762 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1183438001763 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1183438001764 Hexamer interface [polypeptide binding]; other site 1183438001765 Hexagonal pore residue; other site 1183438001766 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1183438001767 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1183438001768 Hexamer interface [polypeptide binding]; other site 1183438001769 Hexagonal pore residue; other site 1183438001770 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1183438001771 multimerization interface [polypeptide binding]; other site 1183438001772 RbcX protein; Region: RcbX; pfam02341 1183438001773 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 1183438001774 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1183438001775 homodimer interface [polypeptide binding]; other site 1183438001776 active site 1183438001777 heterodimer interface [polypeptide binding]; other site 1183438001778 catalytic residue [active] 1183438001779 metal binding site [ion binding]; metal-binding site 1183438001780 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1183438001781 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1183438001782 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1183438001783 substrate binding site [chemical binding]; other site 1183438001784 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1183438001785 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1183438001786 substrate binding site [chemical binding]; other site 1183438001787 ligand binding site [chemical binding]; other site 1183438001788 recombinase A; Provisional; Region: recA; PRK09354 1183438001789 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1183438001790 hexamer interface [polypeptide binding]; other site 1183438001791 Walker A motif; other site 1183438001792 ATP binding site [chemical binding]; other site 1183438001793 Walker B motif; other site 1183438001794 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1183438001795 MPN+ (JAMM) motif; other site 1183438001796 Zinc-binding site [ion binding]; other site 1183438001797 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1183438001798 MoaE interaction surface [polypeptide binding]; other site 1183438001799 MoeB interaction surface [polypeptide binding]; other site 1183438001800 thiocarboxylated glycine; other site 1183438001801 hypothetical protein; Validated; Region: PRK07411 1183438001802 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1183438001803 ATP binding site [chemical binding]; other site 1183438001804 substrate interface [chemical binding]; other site 1183438001805 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1183438001806 active site residue [active] 1183438001807 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 1183438001808 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 1183438001809 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1183438001810 DNA binding site [nucleotide binding] 1183438001811 catalytic residue [active] 1183438001812 H2TH interface [polypeptide binding]; other site 1183438001813 putative catalytic residues [active] 1183438001814 turnover-facilitating residue; other site 1183438001815 intercalation triad [nucleotide binding]; other site 1183438001816 8OG recognition residue [nucleotide binding]; other site 1183438001817 putative reading head residues; other site 1183438001818 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1183438001819 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1183438001820 RDD family; Region: RDD; pfam06271 1183438001821 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1183438001822 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1183438001823 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1183438001824 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1183438001825 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1183438001826 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1183438001827 cell division protein FtsZ; Validated; Region: PRK09330 1183438001828 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1183438001829 nucleotide binding site [chemical binding]; other site 1183438001830 SulA interaction site; other site 1183438001831 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1183438001832 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1183438001833 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1183438001834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438001835 ATP binding site [chemical binding]; other site 1183438001836 putative Mg++ binding site [ion binding]; other site 1183438001837 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438001838 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1183438001839 nucleotide binding region [chemical binding]; other site 1183438001840 ATP-binding site [chemical binding]; other site 1183438001841 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1183438001842 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1183438001843 Restriction endonuclease; Region: Mrr_cat; pfam04471 1183438001844 Predicted ATPase [General function prediction only]; Region: COG4637 1183438001845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438001846 Walker A/P-loop; other site 1183438001847 ATP binding site [chemical binding]; other site 1183438001848 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1183438001849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438001850 ATP-binding site [chemical binding]; other site 1183438001851 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1183438001852 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1183438001853 PLD-like domain; Region: PLDc_2; pfam13091 1183438001854 putative active site [active] 1183438001855 catalytic site [active] 1183438001856 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1183438001857 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1183438001858 [2Fe-2S] cluster binding site [ion binding]; other site 1183438001859 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1183438001860 putative alpha subunit interface [polypeptide binding]; other site 1183438001861 putative active site [active] 1183438001862 putative substrate binding site [chemical binding]; other site 1183438001863 Fe binding site [ion binding]; other site 1183438001864 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1183438001865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438001866 Coenzyme A binding pocket [chemical binding]; other site 1183438001867 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1183438001868 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1183438001869 glutaminase active site [active] 1183438001870 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1183438001871 dimer interface [polypeptide binding]; other site 1183438001872 active site 1183438001873 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1183438001874 dimer interface [polypeptide binding]; other site 1183438001875 active site 1183438001876 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1183438001877 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1183438001878 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1183438001879 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1183438001880 putative dimer interface [polypeptide binding]; other site 1183438001881 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438001882 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1183438001883 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1183438001884 active site residue [active] 1183438001885 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1183438001886 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1183438001887 Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601 1183438001888 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1183438001889 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1183438001890 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1183438001891 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1183438001892 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1183438001893 Ligand binding site [chemical binding]; other site 1183438001894 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1183438001895 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1183438001896 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1183438001897 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1183438001898 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1183438001899 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1183438001900 Short C-terminal domain; Region: SHOCT; pfam09851 1183438001901 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1183438001902 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1183438001903 RNase E interface [polypeptide binding]; other site 1183438001904 trimer interface [polypeptide binding]; other site 1183438001905 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1183438001906 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1183438001907 RNase E interface [polypeptide binding]; other site 1183438001908 trimer interface [polypeptide binding]; other site 1183438001909 active site 1183438001910 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1183438001911 putative nucleic acid binding region [nucleotide binding]; other site 1183438001912 G-X-X-G motif; other site 1183438001913 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1183438001914 RNA binding site [nucleotide binding]; other site 1183438001915 domain interface; other site 1183438001916 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 1183438001917 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1183438001918 dinuclear metal binding motif [ion binding]; other site 1183438001919 acyl-ACP reductase; Provisional; Region: PRK14982 1183438001920 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1183438001921 NAD(P) binding pocket [chemical binding]; other site 1183438001922 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1183438001923 protein I interface; other site 1183438001924 D2 interface; other site 1183438001925 protein T interface; other site 1183438001926 chlorophyll binding site; other site 1183438001927 beta carotene binding site; other site 1183438001928 pheophytin binding site; other site 1183438001929 manganese-stabilizing polypeptide interface; other site 1183438001930 CP43 interface; other site 1183438001931 protein L interface; other site 1183438001932 oxygen evolving complex binding site; other site 1183438001933 bromide binding site; other site 1183438001934 quinone binding site; other site 1183438001935 Fe binding site [ion binding]; other site 1183438001936 core light harvesting interface; other site 1183438001937 cytochrome b559 alpha subunit interface; other site 1183438001938 cytochrome c-550 interface; other site 1183438001939 protein J interface; other site 1183438001940 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1183438001941 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1183438001942 nucleotide binding site [chemical binding]; other site 1183438001943 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 1183438001944 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1183438001945 metal binding site 2 [ion binding]; metal-binding site 1183438001946 putative DNA binding helix; other site 1183438001947 metal binding site 1 [ion binding]; metal-binding site 1183438001948 dimer interface [polypeptide binding]; other site 1183438001949 structural Zn2+ binding site [ion binding]; other site 1183438001950 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 1183438001951 DNA photolyase; Region: DNA_photolyase; pfam00875 1183438001952 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1183438001953 Domain of unknown function DUF21; Region: DUF21; pfam01595 1183438001954 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1183438001955 Transporter associated domain; Region: CorC_HlyC; smart01091 1183438001956 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1183438001957 30S subunit binding site; other site 1183438001958 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1183438001959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1183438001960 Zn2+ binding site [ion binding]; other site 1183438001961 Mg2+ binding site [ion binding]; other site 1183438001962 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438001963 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1183438001964 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438001965 structural tetrad; other site 1183438001966 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438001967 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438001968 structural tetrad; other site 1183438001969 WD40 repeats; Region: WD40; smart00320 1183438001970 WD domain, G-beta repeat; Region: WD40; pfam00400 1183438001971 Transposase; Region: HTH_Tnp_1; pfam01527 1183438001972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1183438001973 Integrase core domain; Region: rve; pfam00665 1183438001974 Integrase core domain; Region: rve_3; pfam13683 1183438001975 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1183438001976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438001977 NAD(P) binding site [chemical binding]; other site 1183438001978 active site 1183438001979 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1183438001980 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1183438001981 FAD binding site [chemical binding]; other site 1183438001982 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438001983 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438001984 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1183438001985 substrate binding site [chemical binding]; other site 1183438001986 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1183438001987 ATP binding site [chemical binding]; other site 1183438001988 ribosomal protein L32; Validated; Region: rpl32; CHL00152 1183438001989 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1183438001990 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1183438001991 metal binding site 2 [ion binding]; metal-binding site 1183438001992 putative DNA binding helix; other site 1183438001993 metal binding site 1 [ion binding]; metal-binding site 1183438001994 dimer interface [polypeptide binding]; other site 1183438001995 structural Zn2+ binding site [ion binding]; other site 1183438001996 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1183438001997 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1183438001998 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1183438001999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438002000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438002001 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1183438002002 Class II fumarases; Region: Fumarase_classII; cd01362 1183438002003 active site 1183438002004 tetramer interface [polypeptide binding]; other site 1183438002005 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1183438002006 ribosomal protein L21; Region: rpl21; CHL00075 1183438002007 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1183438002008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1183438002009 FIST N domain; Region: FIST; pfam08495 1183438002010 FIST C domain; Region: FIST_C; pfam10442 1183438002011 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1183438002012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438002013 active site 1183438002014 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1183438002015 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1183438002016 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1183438002017 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1183438002018 putative homodimer interface [polypeptide binding]; other site 1183438002019 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1183438002020 heterodimer interface [polypeptide binding]; other site 1183438002021 homodimer interface [polypeptide binding]; other site 1183438002022 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1183438002023 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1183438002024 IHF dimer interface [polypeptide binding]; other site 1183438002025 IHF - DNA interface [nucleotide binding]; other site 1183438002026 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1183438002027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438002028 active site 1183438002029 motif I; other site 1183438002030 motif II; other site 1183438002031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438002032 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438002033 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438002034 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1183438002035 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1183438002036 active site 1183438002037 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1183438002038 active site 1183438002039 nucleotide binding site [chemical binding]; other site 1183438002040 HIGH motif; other site 1183438002041 KMSKS motif; other site 1183438002042 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1183438002043 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1183438002044 putative ribose interaction site [chemical binding]; other site 1183438002045 putative ADP binding site [chemical binding]; other site 1183438002046 signal recognition particle protein; Provisional; Region: PRK10867 1183438002047 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1183438002048 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1183438002049 GTP binding site [chemical binding]; other site 1183438002050 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1183438002051 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1183438002052 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1183438002053 KH domain; Region: KH_4; pfam13083 1183438002054 G-X-X-G motif; other site 1183438002055 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1183438002056 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1183438002057 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1183438002058 active site 1183438002059 catalytic residues [active] 1183438002060 DNA binding site [nucleotide binding] 1183438002061 Int/Topo IB signature motif; other site 1183438002062 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1183438002063 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1183438002064 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1183438002065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438002066 non-specific DNA binding site [nucleotide binding]; other site 1183438002067 salt bridge; other site 1183438002068 sequence-specific DNA binding site [nucleotide binding]; other site 1183438002069 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1183438002070 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1183438002071 active site 1183438002072 TDP-binding site; other site 1183438002073 acceptor substrate-binding pocket; other site 1183438002074 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1183438002075 Protein of unknown function DUF262; Region: DUF262; pfam03235 1183438002076 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1183438002077 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1183438002078 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1183438002079 Walker A/P-loop; other site 1183438002080 ATP binding site [chemical binding]; other site 1183438002081 Q-loop/lid; other site 1183438002082 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1183438002083 ABC transporter signature motif; other site 1183438002084 Walker B; other site 1183438002085 D-loop; other site 1183438002086 H-loop/switch region; other site 1183438002087 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438002088 Family description; Region: VCBS; pfam13517 1183438002089 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438002090 Family description; Region: VCBS; pfam13517 1183438002091 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438002092 FG-GAP repeat; Region: FG-GAP; cl15299 1183438002093 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438002094 TIGR03032 family protein; Region: TIGR03032 1183438002095 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002096 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002097 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438002098 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002099 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002100 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438002101 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002102 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438002103 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002104 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438002105 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002106 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1183438002107 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1183438002108 dimer interface [polypeptide binding]; other site 1183438002109 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1183438002110 active site 1183438002111 Fe binding site [ion binding]; other site 1183438002112 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1183438002113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438002114 S-adenosylmethionine binding site [chemical binding]; other site 1183438002115 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 1183438002116 isocitrate dehydrogenase; Validated; Region: PRK06451 1183438002117 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1183438002118 Protein of unknown function (DUF422); Region: DUF422; cl00991 1183438002119 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438002120 active site 1183438002121 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1183438002122 Glucose inhibited division protein A; Region: GIDA; pfam01134 1183438002123 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1183438002124 Lumazine binding domain; Region: Lum_binding; pfam00677 1183438002125 Lumazine binding domain; Region: Lum_binding; pfam00677 1183438002126 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002127 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438002128 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002129 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002130 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438002131 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002132 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002133 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002134 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1183438002135 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438002136 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438002137 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438002138 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438002139 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438002140 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1183438002141 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1183438002142 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1183438002143 catalytic residues [active] 1183438002144 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1183438002145 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1183438002146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1183438002147 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1183438002148 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1183438002149 active site 1183438002150 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002152 binding surface 1183438002153 TPR motif; other site 1183438002154 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002156 binding surface 1183438002157 TPR motif; other site 1183438002158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002159 binding surface 1183438002160 TPR motif; other site 1183438002161 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1183438002162 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1183438002163 aromatic arch; other site 1183438002164 DCoH dimer interaction site [polypeptide binding]; other site 1183438002165 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1183438002166 DCoH tetramer interaction site [polypeptide binding]; other site 1183438002167 substrate binding site [chemical binding]; other site 1183438002168 RIP metalloprotease RseP; Region: TIGR00054 1183438002169 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1183438002170 active site 1183438002171 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1183438002172 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1183438002173 putative substrate binding region [chemical binding]; other site 1183438002174 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1183438002175 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 1183438002176 active site 1183438002177 Predicted membrane protein [Function unknown]; Region: COG2119 1183438002178 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1183438002179 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1183438002180 C-terminal peptidase (prc); Region: prc; TIGR00225 1183438002181 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438002182 protein binding site [polypeptide binding]; other site 1183438002183 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1183438002184 Catalytic dyad [active] 1183438002185 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 1183438002186 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1183438002187 proposed catalytic triad [active] 1183438002188 active site nucleophile [active] 1183438002189 classical (c) SDRs; Region: SDR_c; cd05233 1183438002190 NAD(P) binding site [chemical binding]; other site 1183438002191 active site 1183438002192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1183438002193 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 1183438002194 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1183438002195 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1183438002196 catalytic triad [active] 1183438002197 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1183438002198 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1183438002199 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1183438002200 Catalytic site; other site 1183438002201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438002202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1183438002203 putative substrate translocation pore; other site 1183438002204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002205 TPR motif; other site 1183438002206 TPR repeat; Region: TPR_11; pfam13414 1183438002207 binding surface 1183438002208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002209 binding surface 1183438002210 TPR motif; other site 1183438002211 TPR repeat; Region: TPR_11; pfam13414 1183438002212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002213 binding surface 1183438002214 TPR motif; other site 1183438002215 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1183438002216 Flavoprotein; Region: Flavoprotein; pfam02441 1183438002217 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1183438002218 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438002219 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438002220 active site 1183438002221 ATP binding site [chemical binding]; other site 1183438002222 substrate binding site [chemical binding]; other site 1183438002223 activation loop (A-loop); other site 1183438002224 TPR repeat; Region: TPR_11; pfam13414 1183438002225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002226 binding surface 1183438002227 TPR motif; other site 1183438002228 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1183438002229 active site 1183438002230 catalytic triad [active] 1183438002231 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1183438002232 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1183438002233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438002234 catalytic residue [active] 1183438002235 Membrane protein of unknown function; Region: DUF360; pfam04020 1183438002236 Heat induced stress protein YflT; Region: YflT; pfam11181 1183438002237 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1183438002238 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1183438002239 TPR repeat; Region: TPR_11; pfam13414 1183438002240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002241 TPR motif; other site 1183438002242 binding surface 1183438002243 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002245 binding surface 1183438002246 TPR motif; other site 1183438002247 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1183438002248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002249 TPR motif; other site 1183438002250 binding surface 1183438002251 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1183438002252 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1183438002253 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438002254 Ligand Binding Site [chemical binding]; other site 1183438002255 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438002256 Ligand Binding Site [chemical binding]; other site 1183438002257 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1183438002258 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1183438002259 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1183438002260 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1183438002261 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1183438002262 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1183438002263 Heat induced stress protein YflT; Region: YflT; pfam11181 1183438002264 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1183438002265 active site 1183438002266 DNA binding site [nucleotide binding] 1183438002267 Int/Topo IB signature motif; other site 1183438002268 Transcriptional regulator; Region: Rrf2; cl17282 1183438002269 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1183438002270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438002271 non-specific DNA binding site [nucleotide binding]; other site 1183438002272 salt bridge; other site 1183438002273 sequence-specific DNA binding site [nucleotide binding]; other site 1183438002274 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438002275 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002276 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002277 conserved hypothetical protein; frameshifted 1183438002278 KOW (Kyprides, Ouzounis, Woese) motif; Region: KOW; smart00739 1183438002279 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1183438002280 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1183438002281 cofactor binding site; other site 1183438002282 DNA binding site [nucleotide binding] 1183438002283 substrate interaction site [chemical binding]; other site 1183438002284 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1183438002285 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1183438002286 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1183438002287 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1183438002288 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1183438002289 Phage capsid family; Region: Phage_capsid; pfam05065 1183438002290 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1183438002291 tape measure domain; Region: tape_meas_nterm; TIGR02675 1183438002292 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 1183438002293 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 1183438002294 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 1183438002295 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 1183438002296 NlpC/P60 family; Region: NLPC_P60; cl17555 1183438002297 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1183438002298 CHASE3 domain; Region: CHASE3; pfam05227 1183438002299 Lysozyme family protein [General function prediction only]; Region: COG5526 1183438002300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1183438002301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438002302 non-specific DNA binding site [nucleotide binding]; other site 1183438002303 salt bridge; other site 1183438002304 sequence-specific DNA binding site [nucleotide binding]; other site 1183438002305 ERF superfamily; Region: ERF; pfam04404 1183438002306 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1183438002307 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1183438002308 carotene isomerase; Region: carot_isom; TIGR02730 1183438002309 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1183438002310 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1183438002311 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1183438002312 CoA-binding site [chemical binding]; other site 1183438002313 ATP-binding [chemical binding]; other site 1183438002314 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1183438002315 hydrophobic ligand binding site; other site 1183438002316 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1183438002317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438002318 S-adenosylmethionine binding site [chemical binding]; other site 1183438002319 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1183438002320 Cupin domain; Region: Cupin_2; cl17218 1183438002321 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1183438002322 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1183438002323 ligand binding site [chemical binding]; other site 1183438002324 NAD binding site [chemical binding]; other site 1183438002325 dimerization interface [polypeptide binding]; other site 1183438002326 catalytic site [active] 1183438002327 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1183438002328 putative L-serine binding site [chemical binding]; other site 1183438002329 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438002330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438002331 active site 1183438002332 phosphorylation site [posttranslational modification] 1183438002333 intermolecular recognition site; other site 1183438002334 dimerization interface [polypeptide binding]; other site 1183438002335 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1183438002336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438002337 active site 1183438002338 phosphorylation site [posttranslational modification] 1183438002339 intermolecular recognition site; other site 1183438002340 dimerization interface [polypeptide binding]; other site 1183438002341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438002342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438002343 putative active site [active] 1183438002344 heme pocket [chemical binding]; other site 1183438002345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438002346 dimer interface [polypeptide binding]; other site 1183438002347 phosphorylation site [posttranslational modification] 1183438002348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438002349 ATP binding site [chemical binding]; other site 1183438002350 Mg2+ binding site [ion binding]; other site 1183438002351 G-X-G motif; other site 1183438002352 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438002353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438002354 active site 1183438002355 phosphorylation site [posttranslational modification] 1183438002356 intermolecular recognition site; other site 1183438002357 dimerization interface [polypeptide binding]; other site 1183438002358 CpeS-like protein; Region: CpeS; pfam09367 1183438002359 HEAT repeats; Region: HEAT_2; pfam13646 1183438002360 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1183438002361 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1183438002362 putative active site [active] 1183438002363 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1183438002364 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1183438002365 putative active site [active] 1183438002366 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1183438002367 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1183438002368 hypothetical protein; frameshifted 1183438002369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002370 binding surface 1183438002371 TPR motif; other site 1183438002372 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002373 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002375 binding surface 1183438002376 TPR motif; other site 1183438002377 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002380 binding surface 1183438002381 TPR motif; other site 1183438002382 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002383 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438002384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002385 binding surface 1183438002386 TPR motif; other site 1183438002387 CHAT domain; Region: CHAT; pfam12770 1183438002388 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1183438002389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438002390 Walker A/P-loop; other site 1183438002391 ATP binding site [chemical binding]; other site 1183438002392 Q-loop/lid; other site 1183438002393 ABC transporter signature motif; other site 1183438002394 Walker B; other site 1183438002395 D-loop; other site 1183438002396 H-loop/switch region; other site 1183438002397 ABC transporter; Region: ABC_tran_2; pfam12848 1183438002398 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1183438002399 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1183438002400 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1183438002401 putative ADP-binding pocket [chemical binding]; other site 1183438002402 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1183438002403 dimer interface [polypeptide binding]; other site 1183438002404 active site 1183438002405 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1183438002406 classical (c) SDRs; Region: SDR_c; cd05233 1183438002407 NAD(P) binding site [chemical binding]; other site 1183438002408 active site 1183438002409 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1183438002410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438002411 active site 1183438002412 motif I; other site 1183438002413 motif II; other site 1183438002414 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1183438002415 substrate binding site [chemical binding]; other site 1183438002416 ATP binding site [chemical binding]; other site 1183438002417 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1183438002418 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438002419 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1183438002420 putative active site [active] 1183438002421 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1183438002422 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438002423 active site 1183438002424 short chain dehydrogenase; Provisional; Region: PRK06701 1183438002425 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1183438002426 NAD binding site [chemical binding]; other site 1183438002427 metal binding site [ion binding]; metal-binding site 1183438002428 active site 1183438002429 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1183438002430 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1183438002431 NAD binding site [chemical binding]; other site 1183438002432 catalytic Zn binding site [ion binding]; other site 1183438002433 structural Zn binding site [ion binding]; other site 1183438002434 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438002435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438002436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438002437 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438002438 Hemerythrin-like domain; Region: Hr-like; cd12108 1183438002439 Fe binding site [ion binding]; other site 1183438002440 chaperone protein DnaJ; Provisional; Region: PRK14293 1183438002441 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1183438002442 HSP70 interaction site [polypeptide binding]; other site 1183438002443 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1183438002444 substrate binding site [polypeptide binding]; other site 1183438002445 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1183438002446 Zn binding sites [ion binding]; other site 1183438002447 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1183438002448 dimer interface [polypeptide binding]; other site 1183438002449 GTPase RsgA; Reviewed; Region: PRK12289 1183438002450 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1183438002451 RNA binding site [nucleotide binding]; other site 1183438002452 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1183438002453 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1183438002454 GTP/Mg2+ binding site [chemical binding]; other site 1183438002455 G4 box; other site 1183438002456 G5 box; other site 1183438002457 G1 box; other site 1183438002458 Switch I region; other site 1183438002459 G2 box; other site 1183438002460 G3 box; other site 1183438002461 Switch II region; other site 1183438002462 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1183438002463 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1183438002464 Moco binding site; other site 1183438002465 metal coordination site [ion binding]; other site 1183438002466 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1183438002467 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1183438002468 active site 1183438002469 intersubunit interface [polypeptide binding]; other site 1183438002470 catalytic residue [active] 1183438002471 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438002472 putative active site [active] 1183438002473 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1183438002474 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1183438002475 substrate binding pocket [chemical binding]; other site 1183438002476 membrane-bound complex binding site; other site 1183438002477 hinge residues; other site 1183438002478 magnesium chelatase subunit H; Provisional; Region: PLN03241 1183438002479 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1183438002480 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1183438002481 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1183438002482 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1183438002483 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1183438002484 DsbD alpha interface [polypeptide binding]; other site 1183438002485 catalytic residues [active] 1183438002486 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1183438002487 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438002488 catalytic residues [active] 1183438002489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002490 TPR repeat; Region: TPR_11; pfam13414 1183438002491 TPR motif; other site 1183438002492 binding surface 1183438002493 TPR repeat; Region: TPR_11; pfam13414 1183438002494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1183438002495 TPR motif; other site 1183438002496 binding surface 1183438002497 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1183438002498 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1183438002499 dimerization interface [polypeptide binding]; other site 1183438002500 DPS ferroxidase diiron center [ion binding]; other site 1183438002501 ion pore; other site 1183438002502 UV-endonuclease UvdE; fragment 1183438002503 UV-endonuclease UvdE; Region: UvdE; cl10036 1183438002504 SnoaL-like domain; Region: SnoaL_2; pfam12680 1183438002505 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1183438002506 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1183438002507 putative active site [active] 1183438002508 homotetrameric interface [polypeptide binding]; other site 1183438002509 metal binding site [ion binding]; metal-binding site 1183438002510 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438002511 putative active site [active] 1183438002512 putative catalytic triad [active] 1183438002513 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1183438002514 catalytic residues [active] 1183438002515 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 1183438002516 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1183438002517 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1183438002518 dihydroorotase; Provisional; Region: PRK07575 1183438002519 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1183438002520 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1183438002521 active site 1183438002522 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1183438002523 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1183438002524 putative NAD(P) binding site [chemical binding]; other site 1183438002525 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1183438002526 SnoaL-like domain; Region: SnoaL_2; pfam12680 1183438002527 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1183438002528 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 1183438002529 NAD(P) binding site [chemical binding]; other site 1183438002530 catalytic residues [active] 1183438002531 SnoaL-like domain; Region: SnoaL_2; pfam12680 1183438002532 SnoaL-like domain; Region: SnoaL_4; pfam13577 1183438002533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1183438002534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1183438002535 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1183438002536 putative effector binding pocket; other site 1183438002537 dimerization interface [polypeptide binding]; other site 1183438002538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438002539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438002540 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438002541 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438002542 active site 1183438002543 catalytic tetrad [active] 1183438002544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438002545 active site 1183438002546 motif I; other site 1183438002547 motif II; other site 1183438002548 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1183438002549 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1183438002550 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1183438002551 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1183438002552 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1183438002553 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1183438002554 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1183438002555 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438002556 putative active site [active] 1183438002557 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1183438002558 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1183438002559 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1183438002560 iron-sulfur cluster [ion binding]; other site 1183438002561 [2Fe-2S] cluster binding site [ion binding]; other site 1183438002562 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1183438002563 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1183438002564 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1183438002565 substrate binding pocket [chemical binding]; other site 1183438002566 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1183438002567 B12 binding site [chemical binding]; other site 1183438002568 cobalt ligand [ion binding]; other site 1183438002569 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1183438002570 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1183438002571 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1183438002572 C-terminal domain interface [polypeptide binding]; other site 1183438002573 GSH binding site (G-site) [chemical binding]; other site 1183438002574 dimer interface [polypeptide binding]; other site 1183438002575 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1183438002576 N-terminal domain interface [polypeptide binding]; other site 1183438002577 dimer interface [polypeptide binding]; other site 1183438002578 substrate binding pocket (H-site) [chemical binding]; other site 1183438002579 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1183438002580 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1183438002581 C-terminal domain interface [polypeptide binding]; other site 1183438002582 GSH binding site (G-site) [chemical binding]; other site 1183438002583 dimer interface [polypeptide binding]; other site 1183438002584 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1183438002585 dimer interface [polypeptide binding]; other site 1183438002586 N-terminal domain interface [polypeptide binding]; other site 1183438002587 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1183438002588 peptidase domain interface [polypeptide binding]; other site 1183438002589 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1183438002590 active site 1183438002591 catalytic triad [active] 1183438002592 calcium binding site [ion binding]; other site 1183438002593 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1183438002594 putative active site [active] 1183438002595 putative metal binding site [ion binding]; other site 1183438002596 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1183438002597 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1183438002598 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1183438002599 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438002600 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438002601 photosystem II reaction center protein K; Provisional; Region: psbK; PRK02553 1183438002602 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1183438002603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1183438002604 HipA N-terminal domain; Region: Couple_hipA; cl11853 1183438002605 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1183438002606 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1183438002607 PilT protein domain-containing protein; fragment 1183438002608 PAS fold; Region: PAS; pfam00989 1183438002609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438002610 putative active site [active] 1183438002611 heme pocket [chemical binding]; other site 1183438002612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1183438002613 Histidine kinase; Region: HisKA_3; pfam07730 1183438002614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438002615 ATP binding site [chemical binding]; other site 1183438002616 Mg2+ binding site [ion binding]; other site 1183438002617 G-X-G motif; other site 1183438002618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438002619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438002620 active site 1183438002621 phosphorylation site [posttranslational modification] 1183438002622 intermolecular recognition site; other site 1183438002623 dimerization interface [polypeptide binding]; other site 1183438002624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438002625 DNA binding residues [nucleotide binding] 1183438002626 dimerization interface [polypeptide binding]; other site 1183438002627 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 1183438002628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438002629 FeS/SAM binding site; other site 1183438002630 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1183438002631 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1183438002632 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1183438002633 protein binding site [polypeptide binding]; other site 1183438002634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438002635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438002636 DNA binding residues [nucleotide binding] 1183438002637 dimerization interface [polypeptide binding]; other site 1183438002638 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1183438002639 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1183438002640 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1183438002641 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1183438002642 purine monophosphate binding site [chemical binding]; other site 1183438002643 dimer interface [polypeptide binding]; other site 1183438002644 putative catalytic residues [active] 1183438002645 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1183438002646 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1183438002647 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 1183438002648 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 1183438002649 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1183438002650 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1183438002651 putative NAD(P) binding site [chemical binding]; other site 1183438002652 active site 1183438002653 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1183438002654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438002655 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1183438002656 MutS domain III; Region: MutS_III; pfam05192 1183438002657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438002658 Walker A/P-loop; other site 1183438002659 ATP binding site [chemical binding]; other site 1183438002660 Q-loop/lid; other site 1183438002661 ABC transporter signature motif; other site 1183438002662 Walker B; other site 1183438002663 D-loop; other site 1183438002664 H-loop/switch region; other site 1183438002665 Smr domain; Region: Smr; pfam01713 1183438002666 PemK-like protein; Region: PemK; pfam02452 1183438002667 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438002668 putative active site [active] 1183438002669 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 1183438002670 active site 1183438002671 intersubunit interface [polypeptide binding]; other site 1183438002672 catalytic residue [active] 1183438002673 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1183438002674 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1183438002675 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1183438002676 putative high light inducible protein; Region: PHA02337 1183438002677 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1183438002678 ribosomal protein S18; Region: rps18; CHL00077 1183438002679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1183438002680 transposase; frameshifted 1183438002681 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1183438002682 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1183438002683 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1183438002684 Fasciclin domain; Region: Fasciclin; pfam02469 1183438002685 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1183438002686 5S rRNA interface [nucleotide binding]; other site 1183438002687 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1183438002688 CTC domain interface [polypeptide binding]; other site 1183438002689 L16 interface [polypeptide binding]; other site 1183438002690 integrase catalytic region; truncated 1183438002691 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1183438002692 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1183438002693 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1183438002694 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1183438002695 active site 1183438002696 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1183438002697 Transposase; Region: HTH_Tnp_1; cl17663 1183438002698 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1183438002699 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1183438002700 active site 1183438002701 PhoD-like phosphatase; Region: PhoD; pfam09423 1183438002702 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1183438002703 putative active site [active] 1183438002704 putative metal binding site [ion binding]; other site 1183438002705 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1183438002706 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1183438002707 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1183438002708 B12 binding site [chemical binding]; other site 1183438002709 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438002710 FeS/SAM binding site; other site 1183438002711 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1183438002712 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1183438002713 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1183438002714 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1183438002715 ATP binding site [chemical binding]; other site 1183438002716 Mg++ binding site [ion binding]; other site 1183438002717 motif III; other site 1183438002718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438002719 nucleotide binding region [chemical binding]; other site 1183438002720 ATP-binding site [chemical binding]; other site 1183438002721 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1183438002722 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1183438002723 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1183438002724 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1183438002725 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1183438002726 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1183438002727 E-class dimer interface [polypeptide binding]; other site 1183438002728 P-class dimer interface [polypeptide binding]; other site 1183438002729 active site 1183438002730 Cu2+ binding site [ion binding]; other site 1183438002731 Zn2+ binding site [ion binding]; other site 1183438002732 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 1183438002733 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1183438002734 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1183438002735 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1183438002736 Ligand binding site; other site 1183438002737 Putative Catalytic site; other site 1183438002738 DXD motif; other site 1183438002739 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1183438002740 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1183438002741 catalytic loop [active] 1183438002742 iron binding site [ion binding]; other site 1183438002743 Photosystem II protein; Region: PSII; cl08223 1183438002744 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 1183438002745 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 1183438002746 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1183438002747 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1183438002748 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1183438002749 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1183438002750 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 1183438002751 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1183438002752 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1183438002753 homodimer interface [polypeptide binding]; other site 1183438002754 NADP binding site [chemical binding]; other site 1183438002755 substrate binding site [chemical binding]; other site 1183438002756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1183438002757 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1183438002758 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1183438002759 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1183438002760 GTP-binding protein Der; Reviewed; Region: PRK00093 1183438002761 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1183438002762 G1 box; other site 1183438002763 GTP/Mg2+ binding site [chemical binding]; other site 1183438002764 Switch I region; other site 1183438002765 G2 box; other site 1183438002766 Switch II region; other site 1183438002767 G3 box; other site 1183438002768 G4 box; other site 1183438002769 G5 box; other site 1183438002770 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1183438002771 G1 box; other site 1183438002772 GTP/Mg2+ binding site [chemical binding]; other site 1183438002773 Switch I region; other site 1183438002774 G2 box; other site 1183438002775 G3 box; other site 1183438002776 Switch II region; other site 1183438002777 G4 box; other site 1183438002778 G5 box; other site 1183438002779 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1183438002780 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1183438002781 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1183438002782 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1183438002783 domain interfaces; other site 1183438002784 active site 1183438002785 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 1183438002786 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1183438002787 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1183438002788 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1183438002789 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1183438002790 lipoyl synthase; Provisional; Region: PRK12928 1183438002791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438002792 FeS/SAM binding site; other site 1183438002793 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1183438002794 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1183438002795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1183438002796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438002797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438002798 DNA binding residues [nucleotide binding] 1183438002799 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1183438002800 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1183438002801 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1183438002802 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1183438002803 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 1183438002804 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 1183438002805 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1183438002806 S-layer homology domain; Region: SLH; pfam00395 1183438002807 S-layer homology domain; Region: SLH; pfam00395 1183438002808 S-layer homology domain; Region: SLH; pfam00395 1183438002809 S-layer homology domain; Region: SLH; pfam00395 1183438002810 S-layer homology domain; Region: SLH; pfam00395 1183438002811 Predicted integral membrane protein [Function unknown]; Region: COG5616 1183438002812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002813 TPR motif; other site 1183438002814 binding surface 1183438002815 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1183438002816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002817 TPR motif; other site 1183438002818 binding surface 1183438002819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438002820 binding surface 1183438002821 TPR motif; other site 1183438002822 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1183438002823 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1183438002824 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1183438002825 protein binding site [polypeptide binding]; other site 1183438002826 YGGT family; Region: YGGT; pfam02325 1183438002827 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1183438002828 intersubunit interface [polypeptide binding]; other site 1183438002829 active site 1183438002830 catalytic residue [active] 1183438002831 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438002832 catalytic motif [active] 1183438002833 Catalytic residue [active] 1183438002834 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1183438002835 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1183438002836 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1183438002837 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1183438002838 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1183438002839 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1183438002840 putative catalytic site [active] 1183438002841 putative phosphate binding site [ion binding]; other site 1183438002842 active site 1183438002843 metal binding site A [ion binding]; metal-binding site 1183438002844 DNA binding site [nucleotide binding] 1183438002845 putative AP binding site [nucleotide binding]; other site 1183438002846 putative metal binding site B [ion binding]; other site 1183438002847 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1183438002848 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438002849 active site 1183438002850 metal binding site [ion binding]; metal-binding site 1183438002851 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 1183438002852 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1183438002853 ATP binding site [chemical binding]; other site 1183438002854 putative Mg++ binding site [ion binding]; other site 1183438002855 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1183438002856 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438002857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438002858 active site 1183438002859 phosphorylation site [posttranslational modification] 1183438002860 intermolecular recognition site; other site 1183438002861 dimerization interface [polypeptide binding]; other site 1183438002862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438002863 PAS domain; Region: PAS_9; pfam13426 1183438002864 putative active site [active] 1183438002865 heme pocket [chemical binding]; other site 1183438002866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438002867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438002868 dimer interface [polypeptide binding]; other site 1183438002869 phosphorylation site [posttranslational modification] 1183438002870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438002871 ATP binding site [chemical binding]; other site 1183438002872 Mg2+ binding site [ion binding]; other site 1183438002873 G-X-G motif; other site 1183438002874 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1183438002875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438002876 ATP binding site [chemical binding]; other site 1183438002877 Mg2+ binding site [ion binding]; other site 1183438002878 G-X-G motif; other site 1183438002879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438002880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438002881 dimer interface [polypeptide binding]; other site 1183438002882 phosphorylation site [posttranslational modification] 1183438002883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438002884 ATP binding site [chemical binding]; other site 1183438002885 Mg2+ binding site [ion binding]; other site 1183438002886 G-X-G motif; other site 1183438002887 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438002888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438002889 active site 1183438002890 phosphorylation site [posttranslational modification] 1183438002891 intermolecular recognition site; other site 1183438002892 dimerization interface [polypeptide binding]; other site 1183438002893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1183438002894 ATP binding site [chemical binding]; other site 1183438002895 Mg2+ binding site [ion binding]; other site 1183438002896 G-X-G motif; other site 1183438002897 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1183438002898 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1183438002899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1183438002900 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1183438002901 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1183438002902 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1183438002903 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1183438002904 PGAP1-like protein; Region: PGAP1; pfam07819 1183438002905 30S ribosomal protein S1; Reviewed; Region: PRK07400 1183438002906 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1183438002907 RNA binding site [nucleotide binding]; other site 1183438002908 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1183438002909 RNA binding site [nucleotide binding]; other site 1183438002910 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1183438002911 RNA binding site [nucleotide binding]; other site 1183438002912 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 1183438002913 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1183438002914 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1183438002915 dimerization interface [polypeptide binding]; other site 1183438002916 active site 1183438002917 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1183438002918 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002919 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438002920 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002921 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002922 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438002923 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438002924 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1183438002925 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1183438002926 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1183438002927 ATP-grasp domain; Region: ATP-grasp; pfam02222 1183438002928 AIR carboxylase; Region: AIRC; pfam00731 1183438002929 Kelch motif; Region: Kelch_1; pfam01344 1183438002930 Kelch motif; Region: Kelch_1; pfam01344 1183438002931 Kelch motif; Region: Kelch_1; pfam01344 1183438002932 Kelch domain; Region: Kelch; smart00612 1183438002933 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1183438002934 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1183438002935 catalytic motif [active] 1183438002936 Zn binding site [ion binding]; other site 1183438002937 RibD C-terminal domain; Region: RibD_C; cl17279 1183438002938 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 1183438002939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438002940 Walker A motif; other site 1183438002941 ATP binding site [chemical binding]; other site 1183438002942 Walker B motif; other site 1183438002943 arginine finger; other site 1183438002944 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1183438002945 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1183438002946 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1183438002947 Walker A/P-loop; other site 1183438002948 ATP binding site [chemical binding]; other site 1183438002949 Q-loop/lid; other site 1183438002950 ABC transporter signature motif; other site 1183438002951 Walker B; other site 1183438002952 D-loop; other site 1183438002953 H-loop/switch region; other site 1183438002954 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1183438002955 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1183438002956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1183438002957 Walker A/P-loop; other site 1183438002958 ATP binding site [chemical binding]; other site 1183438002959 Q-loop/lid; other site 1183438002960 ABC transporter signature motif; other site 1183438002961 Walker B; other site 1183438002962 D-loop; other site 1183438002963 H-loop/switch region; other site 1183438002964 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1183438002965 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1183438002966 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1183438002967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438002968 dimer interface [polypeptide binding]; other site 1183438002969 conserved gate region; other site 1183438002970 putative PBP binding loops; other site 1183438002971 ABC-ATPase subunit interface; other site 1183438002972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1183438002973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438002974 dimer interface [polypeptide binding]; other site 1183438002975 conserved gate region; other site 1183438002976 putative PBP binding loops; other site 1183438002977 ABC-ATPase subunit interface; other site 1183438002978 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1183438002979 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1183438002980 peptide binding site [polypeptide binding]; other site 1183438002981 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1183438002982 proposed catalytic triad [active] 1183438002983 active site nucleophile [active] 1183438002984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438002985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438002986 active site 1183438002987 phosphorylation site [posttranslational modification] 1183438002988 intermolecular recognition site; other site 1183438002989 dimerization interface [polypeptide binding]; other site 1183438002990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438002991 DNA binding site [nucleotide binding] 1183438002992 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1183438002993 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1183438002994 NADP binding site [chemical binding]; other site 1183438002995 active site 1183438002996 steroid binding site; other site 1183438002997 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1183438002998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1183438002999 dimerization interface [polypeptide binding]; other site 1183438003000 putative DNA binding site [nucleotide binding]; other site 1183438003001 putative Zn2+ binding site [ion binding]; other site 1183438003002 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1183438003003 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1183438003004 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1183438003005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438003006 NAD(P) binding site [chemical binding]; other site 1183438003007 active site 1183438003008 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1183438003009 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1183438003010 active site 1183438003011 DNA binding site [nucleotide binding] 1183438003012 Int/Topo IB signature motif; other site 1183438003013 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1183438003014 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1183438003015 translation initiation factor IF-2; Region: IF-2; TIGR00487 1183438003016 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1183438003017 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1183438003018 G1 box; other site 1183438003019 putative GEF interaction site [polypeptide binding]; other site 1183438003020 GTP/Mg2+ binding site [chemical binding]; other site 1183438003021 Switch I region; other site 1183438003022 G2 box; other site 1183438003023 G3 box; other site 1183438003024 Switch II region; other site 1183438003025 G4 box; other site 1183438003026 G5 box; other site 1183438003027 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1183438003028 Translation-initiation factor 2; Region: IF-2; pfam11987 1183438003029 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1183438003030 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1183438003031 N-terminal plug; other site 1183438003032 ligand-binding site [chemical binding]; other site 1183438003033 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438003034 putative active site [active] 1183438003035 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438003036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438003037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438003038 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438003039 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 1183438003040 PBP superfamily domain; Region: PBP_like_2; pfam12849 1183438003041 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1183438003042 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438003043 active site 1183438003044 metal binding site [ion binding]; metal-binding site 1183438003045 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 1183438003046 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1183438003047 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 1183438003048 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 1183438003049 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1183438003050 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1183438003051 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1183438003052 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1183438003053 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1183438003054 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1183438003055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438003056 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1183438003057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438003058 DNA binding residues [nucleotide binding] 1183438003059 Family description; Region: VCBS; pfam13517 1183438003060 Family description; Region: VCBS; pfam13517 1183438003061 Family description; Region: VCBS; pfam13517 1183438003062 Family description; Region: VCBS; pfam13517 1183438003063 Family description; Region: VCBS; pfam13517 1183438003064 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1183438003065 active site 1183438003066 homodimer interface [polypeptide binding]; other site 1183438003067 SAM binding site [chemical binding]; other site 1183438003068 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1183438003069 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1183438003070 homodimer interface [polypeptide binding]; other site 1183438003071 metal binding site [ion binding]; metal-binding site 1183438003072 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1183438003073 homodimer interface [polypeptide binding]; other site 1183438003074 active site 1183438003075 putative chemical substrate binding site [chemical binding]; other site 1183438003076 metal binding site [ion binding]; metal-binding site 1183438003077 Putative restriction endonuclease; Region: Uma2; pfam05685 1183438003078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438003079 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1183438003080 Walker A motif; other site 1183438003081 ATP binding site [chemical binding]; other site 1183438003082 Walker B motif; other site 1183438003083 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1183438003084 dinuclear metal binding motif [ion binding]; other site 1183438003085 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1183438003086 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1183438003087 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1183438003088 metal binding site [ion binding]; metal-binding site 1183438003089 dimer interface [polypeptide binding]; other site 1183438003090 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1183438003091 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1183438003092 active site 1183438003093 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1183438003094 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1183438003095 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1183438003096 Active_site [active] 1183438003097 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1183438003098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1183438003099 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1183438003100 Probable transposase; Region: OrfB_IS605; pfam01385 1183438003101 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1183438003102 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1183438003103 putative active site [active] 1183438003104 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1183438003105 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1183438003106 substrate binding site [chemical binding]; other site 1183438003107 ATP binding site [chemical binding]; other site 1183438003108 hypothetical protein; Provisional; Region: PRK08912 1183438003109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1183438003110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438003111 homodimer interface [polypeptide binding]; other site 1183438003112 catalytic residue [active] 1183438003113 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1183438003114 dimer interface [polypeptide binding]; other site 1183438003115 FMN binding site [chemical binding]; other site 1183438003116 NADPH bind site [chemical binding]; other site 1183438003117 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1183438003118 active site 1183438003119 Zn2+ binding site [ion binding]; other site 1183438003120 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1183438003121 Cupin domain; Region: Cupin_2; pfam07883 1183438003122 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1183438003123 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 1183438003124 Ycf46; Provisional; Region: ycf46; CHL00195 1183438003125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438003126 Walker A motif; other site 1183438003127 ATP binding site [chemical binding]; other site 1183438003128 Walker B motif; other site 1183438003129 arginine finger; other site 1183438003130 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1183438003131 hypothetical protein; Provisional; Region: PRK06208 1183438003132 intersubunit interface [polypeptide binding]; other site 1183438003133 active site 1183438003134 Zn2+ binding site [ion binding]; other site 1183438003135 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1183438003136 Glycoprotease family; Region: Peptidase_M22; pfam00814 1183438003137 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 1183438003138 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1183438003139 peptidase domain interface [polypeptide binding]; other site 1183438003140 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1183438003141 active site 1183438003142 catalytic triad [active] 1183438003143 calcium binding site [ion binding]; other site 1183438003144 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1183438003145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1183438003146 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438003147 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438003148 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438003149 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438003150 recombination protein RecR; Reviewed; Region: recR; PRK00076 1183438003151 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1183438003152 RecR protein; Region: RecR; pfam02132 1183438003153 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1183438003154 putative active site [active] 1183438003155 putative metal-binding site [ion binding]; other site 1183438003156 tetramer interface [polypeptide binding]; other site 1183438003157 hypothetical protein; Validated; Region: PRK00153 1183438003158 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1183438003159 proposed catalytic triad [active] 1183438003160 active site nucleophile [active] 1183438003161 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1183438003162 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1183438003163 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1183438003164 GIY-YIG motif/motif A; other site 1183438003165 active site 1183438003166 catalytic site [active] 1183438003167 putative DNA binding site [nucleotide binding]; other site 1183438003168 metal binding site [ion binding]; metal-binding site 1183438003169 UvrB/uvrC motif; Region: UVR; pfam02151 1183438003170 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1183438003171 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1183438003172 active site 1183438003173 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438003174 putative active site [active] 1183438003175 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1183438003176 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1183438003177 putative phosphate acyltransferase; Provisional; Region: PRK05331 1183438003178 TolA protein; Region: tolA_full; TIGR02794 1183438003179 TonB C terminal; Region: TonB_2; pfam13103 1183438003180 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1183438003181 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1183438003182 active site 1183438003183 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1183438003184 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1183438003185 dimer interface [polypeptide binding]; other site 1183438003186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438003187 catalytic residue [active] 1183438003188 Rrf2 family protein; Region: rrf2_super; TIGR00738 1183438003189 Transcriptional regulator; Region: Rrf2; pfam02082 1183438003190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438003191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438003192 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1183438003193 NAD(P) binding site [chemical binding]; other site 1183438003194 active site 1183438003195 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1183438003196 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1183438003197 active site 1183438003198 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1183438003199 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1183438003200 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1183438003201 Ligand Binding Site [chemical binding]; other site 1183438003202 MazE family transcripitonal regulator; truncated 1183438003203 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438003204 putative active site [active] 1183438003205 membrane protein; Provisional; Region: PRK14419 1183438003206 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 1183438003207 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438003208 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438003209 active site 1183438003210 ATP binding site [chemical binding]; other site 1183438003211 substrate binding site [chemical binding]; other site 1183438003212 activation loop (A-loop); other site 1183438003213 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438003214 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438003215 structural tetrad; other site 1183438003216 PQQ-like domain; Region: PQQ_2; pfam13360 1183438003217 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1183438003218 MPT binding site; other site 1183438003219 trimer interface [polypeptide binding]; other site 1183438003220 tellurium resistance terB-like protein; Region: terB_like; cd07177 1183438003221 metal binding site [ion binding]; metal-binding site 1183438003222 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1183438003223 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1183438003224 SelR domain; Region: SelR; pfam01641 1183438003225 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1183438003226 putative active site [active] 1183438003227 catalytic residue [active] 1183438003228 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1183438003229 active site 1183438003230 dimerization interface [polypeptide binding]; other site 1183438003231 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 1183438003232 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1183438003233 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1183438003234 aromatic acid decarboxylase; Validated; Region: PRK05920 1183438003235 Flavoprotein; Region: Flavoprotein; pfam02441 1183438003236 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1183438003237 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1183438003238 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1183438003239 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1183438003240 N- and C-terminal domain interface [polypeptide binding]; other site 1183438003241 active site 1183438003242 MgATP binding site [chemical binding]; other site 1183438003243 catalytic site [active] 1183438003244 metal binding site [ion binding]; metal-binding site 1183438003245 glycerol binding site [chemical binding]; other site 1183438003246 homotetramer interface [polypeptide binding]; other site 1183438003247 homodimer interface [polypeptide binding]; other site 1183438003248 FBP binding site [chemical binding]; other site 1183438003249 protein IIAGlc interface [polypeptide binding]; other site 1183438003250 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1183438003251 catalytic core [active] 1183438003252 Tic22-like family; Region: Tic22; pfam04278 1183438003253 Tic22-like family; Region: Tic22; pfam04278 1183438003254 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1183438003255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438003256 S-adenosylmethionine binding site [chemical binding]; other site 1183438003257 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1183438003258 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1183438003259 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1183438003260 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1183438003261 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1183438003262 Amidinotransferase; Region: Amidinotransf; pfam02274 1183438003263 Uncharacterized conserved protein [Function unknown]; Region: COG1915 1183438003264 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 1183438003265 homodimer interface [polypeptide binding]; other site 1183438003266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438003267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438003268 dimer interface [polypeptide binding]; other site 1183438003269 phosphorylation site [posttranslational modification] 1183438003270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438003271 ATP binding site [chemical binding]; other site 1183438003272 Mg2+ binding site [ion binding]; other site 1183438003273 G-X-G motif; other site 1183438003274 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1183438003275 DNA protecting protein DprA; Region: dprA; TIGR00732 1183438003276 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1183438003277 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1183438003278 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1183438003279 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1183438003280 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1183438003281 Cell division protein FtsA; Region: FtsA; cl17206 1183438003282 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1183438003283 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1183438003284 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1183438003285 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1183438003286 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1183438003287 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438003288 putative active site [active] 1183438003289 Isochorismatase family; Region: Isochorismatase; pfam00857 1183438003290 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1183438003291 catalytic triad [active] 1183438003292 conserved cis-peptide bond; other site 1183438003293 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1183438003294 ThiC family; Region: ThiC; pfam01964 1183438003295 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1183438003296 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1183438003297 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1183438003298 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1183438003299 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1183438003300 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1183438003301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438003302 Walker A/P-loop; other site 1183438003303 ATP binding site [chemical binding]; other site 1183438003304 Q-loop/lid; other site 1183438003305 ABC transporter signature motif; other site 1183438003306 Walker B; other site 1183438003307 D-loop; other site 1183438003308 H-loop/switch region; other site 1183438003309 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438003310 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438003311 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1183438003312 NADPH bind site [chemical binding]; other site 1183438003313 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1183438003314 putative FMN binding site [chemical binding]; other site 1183438003315 NADPH bind site [chemical binding]; other site 1183438003316 glutamate racemase; Provisional; Region: PRK00865 1183438003317 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1183438003318 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1183438003319 NodB motif; other site 1183438003320 active site 1183438003321 catalytic site [active] 1183438003322 metal binding site [ion binding]; metal-binding site 1183438003323 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1183438003324 Bacterial Ig-like domain; Region: Big_5; pfam13205 1183438003325 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 1183438003326 active site 1183438003327 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1183438003328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438003329 S-adenosylmethionine binding site [chemical binding]; other site 1183438003330 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1183438003331 Protein of unknown function (DUF2012); Region: DUF2012; pfam09430 1183438003332 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1183438003333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438003334 FeS/SAM binding site; other site 1183438003335 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1183438003336 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1183438003337 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1183438003338 active site 1183438003339 HIGH motif; other site 1183438003340 KMSKS motif; other site 1183438003341 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1183438003342 anticodon binding site; other site 1183438003343 tRNA binding surface [nucleotide binding]; other site 1183438003344 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1183438003345 LabA_like proteins; Region: LabA; cd10911 1183438003346 putative metal binding site [ion binding]; other site 1183438003347 Predicted methyltransferases [General function prediction only]; Region: COG0313 1183438003348 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1183438003349 putative SAM binding site [chemical binding]; other site 1183438003350 putative homodimer interface [polypeptide binding]; other site 1183438003351 AAA domain; Region: AAA_23; pfam13476 1183438003352 AAA domain; Region: AAA_21; pfam13304 1183438003353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438003354 Walker A/P-loop; other site 1183438003355 ATP binding site [chemical binding]; other site 1183438003356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1183438003357 Walker B; other site 1183438003358 D-loop; other site 1183438003359 H-loop/switch region; other site 1183438003360 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 1183438003361 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1183438003362 PemK-like protein; Region: PemK; pfam02452 1183438003363 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1183438003364 DNA polymerase III subunit beta; Validated; Region: PRK05643 1183438003365 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1183438003366 putative DNA binding surface [nucleotide binding]; other site 1183438003367 dimer interface [polypeptide binding]; other site 1183438003368 beta-clamp/clamp loader binding surface; other site 1183438003369 beta-clamp/translesion DNA polymerase binding surface; other site 1183438003370 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1183438003371 S-layer homology domain; Region: SLH; pfam00395 1183438003372 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1183438003373 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1183438003374 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 1183438003375 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1183438003376 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1183438003377 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1183438003378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438003379 Walker A/P-loop; other site 1183438003380 ATP binding site [chemical binding]; other site 1183438003381 Q-loop/lid; other site 1183438003382 ABC transporter signature motif; other site 1183438003383 Walker B; other site 1183438003384 D-loop; other site 1183438003385 H-loop/switch region; other site 1183438003386 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1183438003387 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1183438003388 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1183438003389 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 1183438003390 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1183438003391 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 1183438003392 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1183438003393 Protease prsW family; Region: PrsW-protease; pfam13367 1183438003394 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1183438003395 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 1183438003396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438003397 dimer interface [polypeptide binding]; other site 1183438003398 conserved gate region; other site 1183438003399 putative PBP binding loops; other site 1183438003400 ABC-ATPase subunit interface; other site 1183438003401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438003402 dimer interface [polypeptide binding]; other site 1183438003403 conserved gate region; other site 1183438003404 putative PBP binding loops; other site 1183438003405 ABC-ATPase subunit interface; other site 1183438003406 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1183438003407 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1183438003408 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438003409 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1183438003410 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1183438003411 substrate binding site [chemical binding]; other site 1183438003412 active site 1183438003413 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1183438003414 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1183438003415 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 1183438003416 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1183438003417 putative active site [active] 1183438003418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1183438003419 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1183438003420 Probable transposase; Region: OrfB_IS605; pfam01385 1183438003421 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1183438003422 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1183438003423 Putative restriction endonuclease; Region: Uma2; pfam05685 1183438003424 putative active site [active] 1183438003425 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1183438003426 oligomeric interface; other site 1183438003427 putative active site [active] 1183438003428 homodimer interface [polypeptide binding]; other site 1183438003429 Protein of unknown function DUF45; Region: DUF45; cl00636 1183438003430 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1183438003431 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1183438003432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438003433 ATP binding site [chemical binding]; other site 1183438003434 putative Mg++ binding site [ion binding]; other site 1183438003435 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1183438003436 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1183438003437 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1183438003438 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1183438003439 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1183438003440 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1183438003441 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1183438003442 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1183438003443 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1183438003444 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438003445 putative active site [active] 1183438003446 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1183438003447 Cupin domain; Region: Cupin_2; pfam07883 1183438003448 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1183438003449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438003450 NAD(P) binding site [chemical binding]; other site 1183438003451 active site 1183438003452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438003453 tartrate dehydrogenase; Region: TTC; TIGR02089 1183438003454 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1183438003455 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438003456 Ligand Binding Site [chemical binding]; other site 1183438003457 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1183438003458 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1183438003459 substrate binding site [chemical binding]; other site 1183438003460 hexamer interface [polypeptide binding]; other site 1183438003461 metal binding site [ion binding]; metal-binding site 1183438003462 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1183438003463 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1183438003464 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1183438003465 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1183438003466 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1183438003467 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1183438003468 Walker A/P-loop; other site 1183438003469 ATP binding site [chemical binding]; other site 1183438003470 Q-loop/lid; other site 1183438003471 ABC transporter signature motif; other site 1183438003472 Walker B; other site 1183438003473 D-loop; other site 1183438003474 H-loop/switch region; other site 1183438003475 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1183438003476 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1183438003477 Walker A/P-loop; other site 1183438003478 ATP binding site [chemical binding]; other site 1183438003479 Q-loop/lid; other site 1183438003480 ABC transporter signature motif; other site 1183438003481 Walker B; other site 1183438003482 D-loop; other site 1183438003483 H-loop/switch region; other site 1183438003484 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438003485 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1183438003486 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438003487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438003488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438003489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438003490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438003491 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1183438003492 Putative esterase; Region: Esterase; pfam00756 1183438003493 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438003494 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438003495 putative active site [active] 1183438003496 putative catalytic triad [active] 1183438003497 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1183438003498 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438003499 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 1183438003500 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1183438003501 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1183438003502 active site 1183438003503 Substrate binding site; other site 1183438003504 Mg++ binding site; other site 1183438003505 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438003506 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1183438003507 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1183438003508 TRAM domain; Region: TRAM; cl01282 1183438003509 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1183438003510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438003511 S-adenosylmethionine binding site [chemical binding]; other site 1183438003512 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 1183438003513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438003514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438003515 dimer interface [polypeptide binding]; other site 1183438003516 phosphorylation site [posttranslational modification] 1183438003517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438003518 ATP binding site [chemical binding]; other site 1183438003519 Mg2+ binding site [ion binding]; other site 1183438003520 G-X-G motif; other site 1183438003521 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438003522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438003523 active site 1183438003524 phosphorylation site [posttranslational modification] 1183438003525 intermolecular recognition site; other site 1183438003526 dimerization interface [polypeptide binding]; other site 1183438003527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438003528 DNA binding site [nucleotide binding] 1183438003529 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1183438003530 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1183438003531 dimerization interface [polypeptide binding]; other site 1183438003532 ligand binding site [chemical binding]; other site 1183438003533 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1183438003534 dimer interface [polypeptide binding]; other site 1183438003535 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1183438003536 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438003537 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438003538 phycobillisome linker protein; Region: apcE; CHL00091 1183438003539 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438003540 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438003541 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438003542 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438003543 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438003544 metal-binding heat shock protein; Provisional; Region: PRK00016 1183438003545 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1183438003546 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 1183438003547 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1183438003548 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1183438003549 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1183438003550 TM-ABC transporter signature motif; other site 1183438003551 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1183438003552 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1183438003553 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1183438003554 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1183438003555 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1183438003556 active site 1183438003557 HIGH motif; other site 1183438003558 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1183438003559 KMSKS motif; other site 1183438003560 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1183438003561 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1183438003562 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1183438003563 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 1183438003564 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1183438003565 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1183438003566 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1183438003567 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438003568 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438003569 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438003570 Beta-propeller repeat; Region: SBBP; pfam06739 1183438003571 Beta-propeller repeat; Region: SBBP; pfam06739 1183438003572 Beta-propeller repeat; Region: SBBP; pfam06739 1183438003573 Beta-propeller repeat; Region: SBBP; pfam06739 1183438003574 Beta-propeller repeat; Region: SBBP; pfam06739 1183438003575 Beta-propeller repeat; Region: SBBP; pfam06739 1183438003576 Beta-propeller repeat; Region: SBBP; pfam06739 1183438003577 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438003578 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1183438003579 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1183438003580 FAD binding domain; Region: FAD_binding_4; pfam01565 1183438003581 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1183438003582 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 1183438003583 hypothetical protein; Reviewed; Region: PRK12497 1183438003584 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1183438003585 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1183438003586 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1183438003587 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1183438003588 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1183438003589 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1183438003590 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1183438003591 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1183438003592 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1183438003593 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1183438003594 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1183438003595 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1183438003596 S-formylglutathione hydrolase; Region: PLN02442 1183438003597 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1183438003598 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1183438003599 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1183438003600 TrkA-N domain; Region: TrkA_N; pfam02254 1183438003601 TrkA-C domain; Region: TrkA_C; pfam02080 1183438003602 TrkA-C domain; Region: TrkA_C; pfam02080 1183438003603 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 1183438003604 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1183438003605 DNA-binding interface [nucleotide binding]; DNA binding site 1183438003606 TIGR04255 family protein; Region: sporadTIGR04255 1183438003607 DNA photolyase; Region: DNA_photolyase; pfam00875 1183438003608 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1183438003609 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1183438003610 Ca2+ binding site [ion binding]; other site 1183438003611 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1183438003612 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1183438003613 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1183438003614 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1183438003615 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1183438003616 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1183438003617 Winged helix-turn helix; Region: HTH_29; pfam13551 1183438003618 Homeodomain-like domain; Region: HTH_32; pfam13565 1183438003619 integrase catalytic region; frameshifted 1183438003620 MobA/MobL family; Region: MobA_MobL; pfam03389 1183438003621 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1183438003622 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1183438003623 NodB motif; other site 1183438003624 active site 1183438003625 catalytic site [active] 1183438003626 metal binding site [ion binding]; metal-binding site 1183438003627 Tetratricopeptide repeat; Region: TPR_15; pfam13429 1183438003628 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1183438003629 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1183438003630 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1183438003631 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1183438003632 catalytic residue [active] 1183438003633 Bacterial SH3 domain; Region: SH3_4; pfam06347 1183438003634 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1183438003635 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1183438003636 active site 1183438003637 metal binding site [ion binding]; metal-binding site 1183438003638 prephenate dehydratase; Provisional; Region: PRK11898 1183438003639 Prephenate dehydratase; Region: PDT; pfam00800 1183438003640 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1183438003641 putative L-Phe binding site [chemical binding]; other site 1183438003642 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1183438003643 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1183438003644 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1183438003645 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1183438003646 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1183438003647 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1183438003648 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1183438003649 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 1183438003650 pyruvate kinase; Provisional; Region: PRK06354 1183438003651 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1183438003652 active site 1183438003653 domain interfaces; other site 1183438003654 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1183438003655 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1183438003656 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1183438003657 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1183438003658 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1183438003659 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1183438003660 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1183438003661 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1183438003662 nucleoside/Zn binding site; other site 1183438003663 dimer interface [polypeptide binding]; other site 1183438003664 catalytic motif [active] 1183438003665 TPR repeat; Region: TPR_11; pfam13414 1183438003666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438003667 binding surface 1183438003668 TPR motif; other site 1183438003669 TPR repeat; Region: TPR_11; pfam13414 1183438003670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438003671 binding surface 1183438003672 TPR motif; other site 1183438003673 TPR repeat; Region: TPR_11; pfam13414 1183438003674 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1183438003675 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1183438003676 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1183438003677 Uncharacterized protein family (UPF0262); Region: UPF0262; cl11489 1183438003678 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1183438003679 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1183438003680 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1183438003681 active site 1183438003682 dimer interface [polypeptide binding]; other site 1183438003683 motif 1; other site 1183438003684 motif 2; other site 1183438003685 motif 3; other site 1183438003686 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1183438003687 anticodon binding site; other site 1183438003688 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1183438003689 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1183438003690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438003691 alcohol dehydrogenase; frameshifted 1183438003692 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1183438003693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438003694 NAD(P) binding site [chemical binding]; other site 1183438003695 active site 1183438003696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438003697 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438003698 active site 1183438003699 catalytic tetrad [active] 1183438003700 Cupin domain; Region: Cupin_2; pfam07883 1183438003701 short-chain dehydrogenase/reductase SDR; fragment 1183438003702 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1183438003703 O-methyltransferase; Region: Methyltransf_2; pfam00891 1183438003704 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1183438003705 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1183438003706 putative NAD(P) binding site [chemical binding]; other site 1183438003707 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438003708 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1183438003709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438003710 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1183438003711 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1183438003712 active site 1183438003713 catalytic site [active] 1183438003714 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1183438003715 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 1183438003716 PA/protease or protease-like domain interface [polypeptide binding]; other site 1183438003717 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 1183438003718 Peptidase family M28; Region: Peptidase_M28; pfam04389 1183438003719 metal binding site [ion binding]; metal-binding site 1183438003720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1183438003721 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1183438003722 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1183438003723 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 1183438003724 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1183438003725 phosphoribulokinase; Provisional; Region: PRK07429 1183438003726 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1183438003727 active site 1183438003728 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1183438003729 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1183438003730 substrate binding site [chemical binding]; other site 1183438003731 catalytic Zn binding site [ion binding]; other site 1183438003732 NAD binding site [chemical binding]; other site 1183438003733 structural Zn binding site [ion binding]; other site 1183438003734 dimer interface [polypeptide binding]; other site 1183438003735 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1183438003736 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1183438003737 metal ion-dependent adhesion site (MIDAS); other site 1183438003738 argininosuccinate lyase; Provisional; Region: PRK00855 1183438003739 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1183438003740 active sites [active] 1183438003741 tetramer interface [polypeptide binding]; other site 1183438003742 glutamine synthetase, type I; Region: GlnA; TIGR00653 1183438003743 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1183438003744 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1183438003745 Low affinity iron permease; Region: Iron_permease; pfam04120 1183438003746 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1183438003747 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1183438003748 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1183438003749 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1183438003750 Walker A/P-loop; other site 1183438003751 ATP binding site [chemical binding]; other site 1183438003752 Q-loop/lid; other site 1183438003753 ABC transporter signature motif; other site 1183438003754 Walker B; other site 1183438003755 D-loop; other site 1183438003756 H-loop/switch region; other site 1183438003757 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1183438003758 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1183438003759 N-terminal plug; other site 1183438003760 ligand-binding site [chemical binding]; other site 1183438003761 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1183438003762 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438003763 active site 1183438003764 metal binding site [ion binding]; metal-binding site 1183438003765 hexamer interface [polypeptide binding]; other site 1183438003766 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 1183438003767 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 1183438003768 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1183438003769 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438003770 putative active site [active] 1183438003771 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1183438003772 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1183438003773 Cl- selectivity filter; other site 1183438003774 Cl- binding residues [ion binding]; other site 1183438003775 pore gating glutamate residue; other site 1183438003776 dimer interface [polypeptide binding]; other site 1183438003777 H+/Cl- coupling transport residue; other site 1183438003778 FOG: CBS domain [General function prediction only]; Region: COG0517 1183438003779 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1183438003780 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1183438003781 Ligand Binding Site [chemical binding]; other site 1183438003782 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438003783 Ligand Binding Site [chemical binding]; other site 1183438003784 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1183438003785 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1183438003786 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1183438003787 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 1183438003788 dimerization interface [polypeptide binding]; other site 1183438003789 active site 1183438003790 metal binding site [ion binding]; metal-binding site 1183438003791 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1183438003792 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1183438003793 anti sigma factor interaction site; other site 1183438003794 regulatory phosphorylation site [posttranslational modification]; other site 1183438003795 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1183438003796 ABC1 family; Region: ABC1; cl17513 1183438003797 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1183438003798 Cytochrome P450; Region: p450; cl12078 1183438003799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438003800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438003801 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1183438003802 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438003803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438003804 active site 1183438003805 phosphorylation site [posttranslational modification] 1183438003806 intermolecular recognition site; other site 1183438003807 dimerization interface [polypeptide binding]; other site 1183438003808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438003809 DNA binding residues [nucleotide binding] 1183438003810 dimerization interface [polypeptide binding]; other site 1183438003811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438003812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438003813 dimer interface [polypeptide binding]; other site 1183438003814 phosphorylation site [posttranslational modification] 1183438003815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438003816 ATP binding site [chemical binding]; other site 1183438003817 Mg2+ binding site [ion binding]; other site 1183438003818 G-X-G motif; other site 1183438003819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438003820 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1183438003821 NADH dehydrogenase; Region: NADHdh; cl00469 1183438003822 short chain dehydrogenase; Provisional; Region: PRK07454 1183438003823 classical (c) SDRs; Region: SDR_c; cd05233 1183438003824 NAD(P) binding site [chemical binding]; other site 1183438003825 active site 1183438003826 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1183438003827 homodecamer interface [polypeptide binding]; other site 1183438003828 GTP cyclohydrolase I; Provisional; Region: PLN03044 1183438003829 active site 1183438003830 putative catalytic site residues [active] 1183438003831 zinc binding site [ion binding]; other site 1183438003832 GTP-CH-I/GFRP interaction surface; other site 1183438003833 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1183438003834 CHASE3 domain; Region: CHASE3; pfam05227 1183438003835 PAS domain; Region: PAS; smart00091 1183438003836 PAS fold; Region: PAS_4; pfam08448 1183438003837 putative active site [active] 1183438003838 heme pocket [chemical binding]; other site 1183438003839 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1183438003840 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1183438003841 PAS domain S-box; Region: sensory_box; TIGR00229 1183438003842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438003843 putative active site [active] 1183438003844 heme pocket [chemical binding]; other site 1183438003845 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1183438003846 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1183438003847 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1183438003848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1183438003849 metal binding site [ion binding]; metal-binding site 1183438003850 active site 1183438003851 I-site; other site 1183438003852 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1183438003853 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1183438003854 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1183438003855 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1183438003856 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1183438003857 putative NAD(P) binding site [chemical binding]; other site 1183438003858 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1183438003859 Fasciclin domain; Region: Fasciclin; pfam02469 1183438003860 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1183438003861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438003862 NAD(P) binding site [chemical binding]; other site 1183438003863 active site 1183438003864 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1183438003865 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1183438003866 dimer interface [polypeptide binding]; other site 1183438003867 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1183438003868 catalytic triad [active] 1183438003869 Divergent AAA domain; Region: AAA_4; pfam04326 1183438003870 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1183438003871 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1183438003872 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1183438003873 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438003874 putative active site [active] 1183438003875 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1183438003876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1183438003877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438003878 dimer interface [polypeptide binding]; other site 1183438003879 conserved gate region; other site 1183438003880 putative PBP binding loops; other site 1183438003881 ABC-ATPase subunit interface; other site 1183438003882 Predicted membrane protein [Function unknown]; Region: COG3686 1183438003883 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1183438003884 Fasciclin domain; Region: Fasciclin; pfam02469 1183438003885 heat shock protein 90; Provisional; Region: PRK05218 1183438003886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438003887 ATP binding site [chemical binding]; other site 1183438003888 Mg2+ binding site [ion binding]; other site 1183438003889 G-X-G motif; other site 1183438003890 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 1183438003891 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438003892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438003893 active site 1183438003894 phosphorylation site [posttranslational modification] 1183438003895 intermolecular recognition site; other site 1183438003896 dimerization interface [polypeptide binding]; other site 1183438003897 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438003898 DNA binding site [nucleotide binding] 1183438003899 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1183438003900 Permease; Region: Permease; cl00510 1183438003901 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1183438003902 UbiA prenyltransferase family; Region: UbiA; pfam01040 1183438003903 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1183438003904 ThiS interaction site; other site 1183438003905 putative active site [active] 1183438003906 tetramer interface [polypeptide binding]; other site 1183438003907 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 1183438003908 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1183438003909 active site 1183438003910 ATP-binding site [chemical binding]; other site 1183438003911 pantoate-binding site; other site 1183438003912 HXXH motif; other site 1183438003913 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1183438003914 CMP-binding site; other site 1183438003915 The sites determining sugar specificity; other site 1183438003916 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1183438003917 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1183438003918 Predicted membrane protein [Function unknown]; Region: COG3463 1183438003919 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1183438003920 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1183438003921 Elongation factor TS; Region: EF_TS; pfam00889 1183438003922 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1183438003923 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1183438003924 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1183438003925 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1183438003926 active site 1183438003927 catalytic residues [active] 1183438003928 metal binding site [ion binding]; metal-binding site 1183438003929 rod shape-determining protein MreB; Provisional; Region: PRK13930 1183438003930 MreB and similar proteins; Region: MreB_like; cd10225 1183438003931 nucleotide binding site [chemical binding]; other site 1183438003932 Mg binding site [ion binding]; other site 1183438003933 putative protofilament interaction site [polypeptide binding]; other site 1183438003934 RodZ interaction site [polypeptide binding]; other site 1183438003935 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 1183438003936 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1183438003937 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1183438003938 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1183438003939 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1183438003940 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1183438003941 G-X-X-G motif; other site 1183438003942 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1183438003943 RxxxH motif; other site 1183438003944 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1183438003945 amino acid transporter; Region: 2A0306; TIGR00909 1183438003946 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1183438003947 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1183438003948 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1183438003949 active site 1183438003950 TIGR03032 family protein; Region: TIGR03032 1183438003951 muropeptide transporter; Validated; Region: ampG; cl17669 1183438003952 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1183438003953 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1183438003954 Family description; Region: UvrD_C_2; pfam13538 1183438003955 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 1183438003956 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1183438003957 Outer membrane efflux protein; Region: OEP; pfam02321 1183438003958 Outer membrane efflux protein; Region: OEP; pfam02321 1183438003959 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438003960 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438003961 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1183438003962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438003963 Walker A/P-loop; other site 1183438003964 ATP binding site [chemical binding]; other site 1183438003965 Q-loop/lid; other site 1183438003966 ABC transporter signature motif; other site 1183438003967 Walker B; other site 1183438003968 D-loop; other site 1183438003969 H-loop/switch region; other site 1183438003970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438003971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438003972 active site 1183438003973 phosphorylation site [posttranslational modification] 1183438003974 intermolecular recognition site; other site 1183438003975 dimerization interface [polypeptide binding]; other site 1183438003976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438003977 DNA binding site [nucleotide binding] 1183438003978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438003979 dimerization interface [polypeptide binding]; other site 1183438003980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438003981 dimer interface [polypeptide binding]; other site 1183438003982 phosphorylation site [posttranslational modification] 1183438003983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438003984 ATP binding site [chemical binding]; other site 1183438003985 Mg2+ binding site [ion binding]; other site 1183438003986 G-X-G motif; other site 1183438003987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438003988 primosomal protein N' Region: priA; TIGR00595 1183438003989 ATP binding site [chemical binding]; other site 1183438003990 putative Mg++ binding site [ion binding]; other site 1183438003991 Dof domain, zinc finger; Region: zf-Dof; pfam02701 1183438003992 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1183438003993 ribonuclease Z; Region: RNase_Z; TIGR02651 1183438003994 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1183438003995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438003996 Walker A/P-loop; other site 1183438003997 ATP binding site [chemical binding]; other site 1183438003998 Q-loop/lid; other site 1183438003999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438004000 ABC transporter signature motif; other site 1183438004001 Walker B; other site 1183438004002 D-loop; other site 1183438004003 H-loop/switch region; other site 1183438004004 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1183438004005 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1183438004006 DNA binding residues [nucleotide binding] 1183438004007 putative dimer interface [polypeptide binding]; other site 1183438004008 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1183438004009 Putative addiction module component; Region: Unstab_antitox; cl09921 1183438004010 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1183438004011 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1183438004012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438004013 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1183438004014 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1183438004015 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1183438004016 active site 1183438004017 catalytic residues [active] 1183438004018 metal binding site [ion binding]; metal-binding site 1183438004019 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1183438004020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1183438004021 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1183438004022 dimerization interface [polypeptide binding]; other site 1183438004023 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438004024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438004025 dimer interface [polypeptide binding]; other site 1183438004026 phosphorylation site [posttranslational modification] 1183438004027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438004028 ATP binding site [chemical binding]; other site 1183438004029 Mg2+ binding site [ion binding]; other site 1183438004030 G-X-G motif; other site 1183438004031 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1183438004032 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1183438004033 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1183438004034 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1183438004035 substrate binding pocket [chemical binding]; other site 1183438004036 chain length determination region; other site 1183438004037 substrate-Mg2+ binding site; other site 1183438004038 catalytic residues [active] 1183438004039 aspartate-rich region 1; other site 1183438004040 active site lid residues [active] 1183438004041 aspartate-rich region 2; other site 1183438004042 S-layer homology domain; Region: SLH; pfam00395 1183438004043 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1183438004044 S-layer homology domain; Region: SLH; pfam00395 1183438004045 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1183438004046 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1183438004047 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1183438004048 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1183438004049 rRNA binding site [nucleotide binding]; other site 1183438004050 predicted 30S ribosome binding site; other site 1183438004051 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1183438004052 active site 1183438004053 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1183438004054 K+ potassium transporter; Region: K_trans; cl15781 1183438004055 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1183438004056 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1183438004057 heme binding pocket [chemical binding]; other site 1183438004058 heme ligand [chemical binding]; other site 1183438004059 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1183438004060 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1183438004061 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 1183438004062 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 1183438004063 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371 1183438004064 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1183438004065 Family description; Region: VCBS; pfam13517 1183438004066 Family description; Region: VCBS; pfam13517 1183438004067 Family description; Region: VCBS; pfam13517 1183438004068 Family description; Region: VCBS; pfam13517 1183438004069 Family description; Region: VCBS; pfam13517 1183438004070 Family description; Region: VCBS; pfam13517 1183438004071 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438004072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438004073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438004074 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1183438004075 Clp amino terminal domain; Region: Clp_N; pfam02861 1183438004076 Clp amino terminal domain; Region: Clp_N; pfam02861 1183438004077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004078 Walker A motif; other site 1183438004079 ATP binding site [chemical binding]; other site 1183438004080 Walker B motif; other site 1183438004081 arginine finger; other site 1183438004082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004083 Walker A motif; other site 1183438004084 ATP binding site [chemical binding]; other site 1183438004085 Walker B motif; other site 1183438004086 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1183438004087 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1183438004088 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1183438004089 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438004090 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1183438004091 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1183438004092 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1183438004093 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1183438004094 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1183438004095 recombination protein F; Reviewed; Region: recF; PRK00064 1183438004096 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1183438004097 Walker A/P-loop; other site 1183438004098 ATP binding site [chemical binding]; other site 1183438004099 Q-loop/lid; other site 1183438004100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438004101 ABC transporter signature motif; other site 1183438004102 Walker B; other site 1183438004103 D-loop; other site 1183438004104 H-loop/switch region; other site 1183438004105 DNA repair protein RadA; Provisional; Region: PRK11823 1183438004106 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1183438004107 Walker A motif; other site 1183438004108 ATP binding site [chemical binding]; other site 1183438004109 Walker B motif; other site 1183438004110 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1183438004111 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1183438004112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1183438004113 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1183438004114 Fe-S cluster binding site [ion binding]; other site 1183438004115 active site 1183438004116 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1183438004117 active site 1183438004118 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1183438004119 active site 1183438004120 metal binding site [ion binding]; metal-binding site 1183438004121 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438004122 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 1183438004123 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438004124 Protein of unknown function (DUF2656); Region: DUF2656; pfam10847 1183438004125 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1183438004126 HEAT repeats; Region: HEAT_2; pfam13646 1183438004127 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1183438004128 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438004129 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438004130 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 1183438004131 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1183438004132 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1183438004133 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1183438004134 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 1183438004135 Na binding site [ion binding]; other site 1183438004136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438004137 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1183438004138 NAD(P) binding site [chemical binding]; other site 1183438004139 active site 1183438004140 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1183438004141 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438004142 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 1183438004143 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438004144 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1183438004145 active site 1183438004146 metal binding site [ion binding]; metal-binding site 1183438004147 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1183438004148 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1183438004149 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438004150 active site 1183438004151 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438004152 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1183438004153 putative ADP-binding pocket [chemical binding]; other site 1183438004154 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1183438004155 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1183438004156 Probable Catalytic site; other site 1183438004157 metal-binding site 1183438004158 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1183438004159 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1183438004160 Ligand binding site; other site 1183438004161 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1183438004162 Chain length determinant protein; Region: Wzz; cl15801 1183438004163 Chain length determinant protein; Region: Wzz; cl15801 1183438004164 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1183438004165 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1183438004166 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1183438004167 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1183438004168 SLBB domain; Region: SLBB; pfam10531 1183438004169 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1183438004170 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1183438004171 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1183438004172 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 1183438004173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438004174 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1183438004175 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1183438004176 classical (c) SDRs; Region: SDR_c; cd05233 1183438004177 NAD(P) binding site [chemical binding]; other site 1183438004178 active site 1183438004179 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1183438004180 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1183438004181 putative ligand binding site [chemical binding]; other site 1183438004182 putative NAD binding site [chemical binding]; other site 1183438004183 catalytic site [active] 1183438004184 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1183438004185 ligand binding site; other site 1183438004186 tetramer interface; other site 1183438004187 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438004188 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438004189 active site 1183438004190 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438004191 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1183438004192 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1183438004193 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1183438004194 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1183438004195 NAD binding site [chemical binding]; other site 1183438004196 putative substrate binding site 2 [chemical binding]; other site 1183438004197 putative substrate binding site 1 [chemical binding]; other site 1183438004198 active site 1183438004199 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1183438004200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438004201 FeS/SAM binding site; other site 1183438004202 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 1183438004203 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1183438004204 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 1183438004205 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1183438004206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004207 Walker A motif; other site 1183438004208 ATP binding site [chemical binding]; other site 1183438004209 Walker B motif; other site 1183438004210 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 1183438004211 RxxxH motif; other site 1183438004212 Clp protease; Region: CLP_protease; pfam00574 1183438004213 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1183438004214 oligomer interface [polypeptide binding]; other site 1183438004215 active site residues [active] 1183438004216 Clp protease; Region: CLP_protease; pfam00574 1183438004217 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1183438004218 oligomer interface [polypeptide binding]; other site 1183438004219 active site residues [active] 1183438004220 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1183438004221 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1183438004222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438004223 active site 1183438004224 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 1183438004225 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 1183438004226 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1183438004227 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438004228 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1183438004229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438004230 DNA binding residues [nucleotide binding] 1183438004231 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1183438004232 putative hydrolase; Provisional; Region: PRK11460 1183438004233 HEAT repeats; Region: HEAT_2; pfam13646 1183438004234 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1183438004235 HEAT repeats; Region: HEAT_2; pfam13646 1183438004236 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1183438004237 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1183438004238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438004239 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1183438004240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438004241 DNA binding residues [nucleotide binding] 1183438004242 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1183438004243 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1183438004244 putative acyl-acceptor binding pocket; other site 1183438004245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1183438004246 Probable transposase; Region: OrfB_IS605; pfam01385 1183438004247 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1183438004248 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1183438004249 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1183438004250 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1183438004251 active site 1183438004252 HIGH motif; other site 1183438004253 dimer interface [polypeptide binding]; other site 1183438004254 KMSKS motif; other site 1183438004255 citrate synthase; Provisional; Region: PRK14036 1183438004256 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1183438004257 oxalacetate binding site [chemical binding]; other site 1183438004258 citrylCoA binding site [chemical binding]; other site 1183438004259 coenzyme A binding site [chemical binding]; other site 1183438004260 catalytic triad [active] 1183438004261 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1183438004262 SnoaL-like domain; Region: SnoaL_3; pfam13474 1183438004263 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1183438004264 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1183438004265 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1183438004266 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1183438004267 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1183438004268 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1183438004269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438004270 FeS/SAM binding site; other site 1183438004271 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1183438004272 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1183438004273 core domain interface [polypeptide binding]; other site 1183438004274 delta subunit interface [polypeptide binding]; other site 1183438004275 epsilon subunit interface [polypeptide binding]; other site 1183438004276 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1183438004277 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1183438004278 substrate binding site [chemical binding]; other site 1183438004279 glutamase interaction surface [polypeptide binding]; other site 1183438004280 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 1183438004281 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 1183438004282 CHASE2 domain; Region: CHASE2; pfam05226 1183438004283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1183438004284 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1183438004285 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1183438004286 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1183438004287 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1183438004288 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1183438004289 acyl-activating enzyme (AAE) consensus motif; other site 1183438004290 putative AMP binding site [chemical binding]; other site 1183438004291 putative active site [active] 1183438004292 putative CoA binding site [chemical binding]; other site 1183438004293 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1183438004294 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1183438004295 putative acyl-acceptor binding pocket; other site 1183438004296 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1183438004297 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1183438004298 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1183438004299 MoxR-like ATPases [General function prediction only]; Region: COG0714 1183438004300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004301 Walker A motif; other site 1183438004302 ATP binding site [chemical binding]; other site 1183438004303 Walker B motif; other site 1183438004304 arginine finger; other site 1183438004305 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1183438004306 Protein of unknown function DUF58; Region: DUF58; pfam01882 1183438004307 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1183438004308 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1183438004309 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1183438004310 Moco binding site; other site 1183438004311 metal coordination site [ion binding]; other site 1183438004312 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1183438004313 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1183438004314 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1183438004315 Family description; Region: VCBS; pfam13517 1183438004316 Homeodomain-like domain; Region: HTH_23; cl17451 1183438004317 Winged helix-turn helix; Region: HTH_29; pfam13551 1183438004318 Homeodomain-like domain; Region: HTH_32; pfam13565 1183438004319 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1183438004320 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1183438004321 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1183438004322 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1183438004323 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1183438004324 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1183438004325 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1183438004326 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1183438004327 TPR repeat; Region: TPR_11; pfam13414 1183438004328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438004329 binding surface 1183438004330 TPR motif; other site 1183438004331 TPR repeat; Region: TPR_11; pfam13414 1183438004332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438004333 binding surface 1183438004334 TPR motif; other site 1183438004335 TPR repeat; Region: TPR_11; pfam13414 1183438004336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438004337 binding surface 1183438004338 TPR motif; other site 1183438004339 TPR repeat; Region: TPR_11; pfam13414 1183438004340 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1183438004341 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1183438004342 homotrimer interface [polypeptide binding]; other site 1183438004343 Walker A motif; other site 1183438004344 GTP binding site [chemical binding]; other site 1183438004345 Walker B motif; other site 1183438004346 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1183438004347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438004348 Walker A/P-loop; other site 1183438004349 ATP binding site [chemical binding]; other site 1183438004350 Q-loop/lid; other site 1183438004351 ABC transporter signature motif; other site 1183438004352 Walker B; other site 1183438004353 D-loop; other site 1183438004354 H-loop/switch region; other site 1183438004355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1183438004356 ParB-like nuclease domain; Region: ParBc; pfam02195 1183438004357 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1183438004358 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1183438004359 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1183438004360 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438004361 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1183438004362 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1183438004363 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438004364 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1183438004365 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1183438004366 dimer interface [polypeptide binding]; other site 1183438004367 putative anticodon binding site; other site 1183438004368 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1183438004369 motif 1; other site 1183438004370 active site 1183438004371 motif 2; other site 1183438004372 motif 3; other site 1183438004373 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1183438004374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004375 Walker A motif; other site 1183438004376 ATP binding site [chemical binding]; other site 1183438004377 Walker B motif; other site 1183438004378 arginine finger; other site 1183438004379 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1183438004380 metal ion-dependent adhesion site (MIDAS); other site 1183438004381 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1183438004382 active site 1183438004383 8-oxo-dGMP binding site [chemical binding]; other site 1183438004384 nudix motif; other site 1183438004385 metal binding site [ion binding]; metal-binding site 1183438004386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438004387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438004388 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1183438004389 GTP1/OBG; Region: GTP1_OBG; pfam01018 1183438004390 Obg GTPase; Region: Obg; cd01898 1183438004391 G1 box; other site 1183438004392 GTP/Mg2+ binding site [chemical binding]; other site 1183438004393 Switch I region; other site 1183438004394 G2 box; other site 1183438004395 G3 box; other site 1183438004396 Switch II region; other site 1183438004397 G4 box; other site 1183438004398 G5 box; other site 1183438004399 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1183438004400 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1183438004401 amidase catalytic site [active] 1183438004402 Zn binding residues [ion binding]; other site 1183438004403 substrate binding site [chemical binding]; other site 1183438004404 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1183438004405 active site 1183438004406 catalytic residues [active] 1183438004407 DNA binding site [nucleotide binding] 1183438004408 Int/Topo IB signature motif; other site 1183438004409 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 1183438004410 5' RNA guide strand anchoring site; other site 1183438004411 active site 1183438004412 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1183438004413 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 1183438004414 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 1183438004415 AAA-like domain; Region: AAA_10; pfam12846 1183438004416 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1183438004417 hypothetical protein; Provisional; Region: PRK02237 1183438004418 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1183438004419 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1183438004420 DNA binding residues [nucleotide binding] 1183438004421 dimer interface [polypeptide binding]; other site 1183438004422 putative metal binding site [ion binding]; other site 1183438004423 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1183438004424 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1183438004425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004426 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1183438004427 Walker A motif; other site 1183438004428 ATP binding site [chemical binding]; other site 1183438004429 Walker B motif; other site 1183438004430 arginine finger; other site 1183438004431 AAA ATPase domain; Region: AAA_16; pfam13191 1183438004432 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1183438004433 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438004434 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438004435 structural tetrad; other site 1183438004436 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438004437 structural tetrad; other site 1183438004438 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438004439 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1183438004440 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1183438004441 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1183438004442 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1183438004443 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1183438004444 active site 1183438004445 catalytic site [active] 1183438004446 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1183438004447 Helix-turn-helix domain; Region: HTH_38; pfam13936 1183438004448 Homeodomain-like domain; Region: HTH_32; pfam13565 1183438004449 Integrase core domain; Region: rve; pfam00665 1183438004450 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1183438004451 Catalytic site [active] 1183438004452 Nuclease-related domain; Region: NERD; pfam08378 1183438004453 plasmid segregation protein ParM; Provisional; Region: PRK13917 1183438004454 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1183438004455 Mg binding site [ion binding]; other site 1183438004456 nucleotide binding site [chemical binding]; other site 1183438004457 putative protofilament interface [polypeptide binding]; other site 1183438004458 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1183438004459 RPB1 interaction site [polypeptide binding]; other site 1183438004460 RPB10 interaction site [polypeptide binding]; other site 1183438004461 RPB11 interaction site [polypeptide binding]; other site 1183438004462 RPB3 interaction site [polypeptide binding]; other site 1183438004463 RPB12 interaction site [polypeptide binding]; other site 1183438004464 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1183438004465 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1183438004466 generic binding surface I; other site 1183438004467 generic binding surface II; other site 1183438004468 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1183438004469 putative catalytic site [active] 1183438004470 putative metal binding site [ion binding]; other site 1183438004471 putative phosphate binding site [ion binding]; other site 1183438004472 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 1183438004473 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1183438004474 Ycf46; Provisional; Region: ycf46; CHL00195 1183438004475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004476 Walker B motif; other site 1183438004477 arginine finger; other site 1183438004478 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1183438004479 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438004480 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438004481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438004482 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438004483 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438004484 DNA polymerase III subunit beta; Validated; Region: PRK05643 1183438004485 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1183438004486 putative DNA binding surface [nucleotide binding]; other site 1183438004487 dimer interface [polypeptide binding]; other site 1183438004488 beta-clamp/clamp loader binding surface; other site 1183438004489 beta-clamp/translesion DNA polymerase binding surface; other site 1183438004490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1183438004491 Zeta toxin; Region: Zeta_toxin; pfam06414 1183438004492 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 1183438004493 PRTRC system protein A; Region: PRTRC_A; TIGR03735 1183438004494 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1183438004495 ATP binding site [chemical binding]; other site 1183438004496 substrate interface [chemical binding]; other site 1183438004497 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1183438004498 Part of AAA domain; Region: AAA_19; pfam13245 1183438004499 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1183438004500 Family description; Region: UvrD_C_2; pfam13538 1183438004501 hypothetical protein; Validated; Region: PRK07413 1183438004502 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1183438004503 Walker A motif; other site 1183438004504 ATP binding site [chemical binding]; other site 1183438004505 Walker B motif; other site 1183438004506 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1183438004507 Walker A motif; other site 1183438004508 ATP binding site [chemical binding]; other site 1183438004509 Walker B motif; other site 1183438004510 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1183438004511 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1183438004512 active site 1183438004513 metal binding site [ion binding]; metal-binding site 1183438004514 interdomain interaction site; other site 1183438004515 response regulator FixJ; Provisional; Region: fixJ; PRK09390 1183438004516 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1183438004517 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1183438004518 RHS Repeat; Region: RHS_repeat; pfam05593 1183438004519 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1183438004520 AAA-like domain; Region: AAA_10; pfam12846 1183438004521 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1183438004522 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1183438004523 active site 1183438004524 catalytic triad [active] 1183438004525 dimer interface [polypeptide binding]; other site 1183438004526 Nuclease-related domain; Region: NERD; pfam08378 1183438004527 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1183438004528 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1183438004529 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1183438004530 Cupin superfamily protein; Region: Cupin_4; pfam08007 1183438004531 Cupin-like domain; Region: Cupin_8; pfam13621 1183438004532 HTH-like domain; Region: HTH_21; pfam13276 1183438004533 Integrase core domain; Region: rve; pfam00665 1183438004534 Integrase core domain; Region: rve_3; pfam13683 1183438004535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1183438004536 Transposase; Region: HTH_Tnp_1; cl17663 1183438004537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1183438004538 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 1183438004539 Calcium binding; Region: Calci_bind_CcbP; pfam11535 1183438004540 response regulator FixJ; Provisional; Region: fixJ; PRK09390 1183438004541 glutamyl-tRNA synthetase; fragment 1183438004542 Protein of unknown function DUF45; Region: DUF45; cl00636 1183438004543 Carboxylesterase family; Region: COesterase; pfam00135 1183438004544 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1183438004545 substrate binding pocket [chemical binding]; other site 1183438004546 catalytic triad [active] 1183438004547 META domain; Region: META; pfam03724 1183438004548 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1183438004549 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1183438004550 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1183438004551 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438004552 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1183438004553 active site 1183438004554 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1183438004555 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1183438004556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438004557 ATP binding site [chemical binding]; other site 1183438004558 putative Mg++ binding site [ion binding]; other site 1183438004559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438004560 nucleotide binding region [chemical binding]; other site 1183438004561 ATP-binding site [chemical binding]; other site 1183438004562 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1183438004563 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 1183438004564 DNA photolyase; Region: DNA_photolyase; pfam00875 1183438004565 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1183438004566 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1183438004567 dimer interface [polypeptide binding]; other site 1183438004568 PYR/PP interface [polypeptide binding]; other site 1183438004569 TPP binding site [chemical binding]; other site 1183438004570 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1183438004571 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1183438004572 TPP-binding site [chemical binding]; other site 1183438004573 dimer interface [polypeptide binding]; other site 1183438004574 putative high light inducible protein; Region: PHA02337 1183438004575 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438004576 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438004577 active site 1183438004578 ATP binding site [chemical binding]; other site 1183438004579 substrate binding site [chemical binding]; other site 1183438004580 activation loop (A-loop); other site 1183438004581 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 1183438004582 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1183438004583 putative NAD(P) binding site [chemical binding]; other site 1183438004584 catalytic Zn binding site [ion binding]; other site 1183438004585 structural Zn binding site [ion binding]; other site 1183438004586 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1183438004587 active site 1183438004588 aconitate hydratase; Validated; Region: PRK07229 1183438004589 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 1183438004590 substrate binding site [chemical binding]; other site 1183438004591 ligand binding site [chemical binding]; other site 1183438004592 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 1183438004593 substrate binding site [chemical binding]; other site 1183438004594 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 1183438004595 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1183438004596 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438004597 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438004598 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438004599 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1183438004600 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1183438004601 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1183438004602 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1183438004603 tetramer interface [polypeptide binding]; other site 1183438004604 TPP-binding site [chemical binding]; other site 1183438004605 heterodimer interface [polypeptide binding]; other site 1183438004606 phosphorylation loop region [posttranslational modification] 1183438004607 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 1183438004608 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1183438004609 alpha subunit interface [polypeptide binding]; other site 1183438004610 TPP binding site [chemical binding]; other site 1183438004611 heterodimer interface [polypeptide binding]; other site 1183438004612 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1183438004613 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1183438004614 S-layer homology domain; Region: SLH; pfam00395 1183438004615 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1183438004616 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1183438004617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438004618 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438004619 DNA binding residues [nucleotide binding] 1183438004620 dimerization interface [polypeptide binding]; other site 1183438004621 Peptidase family M41; Region: Peptidase_M41; pfam01434 1183438004622 Condensation domain; Region: Condensation; pfam00668 1183438004623 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1183438004624 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1183438004625 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1183438004626 acyl-activating enzyme (AAE) consensus motif; other site 1183438004627 AMP binding site [chemical binding]; other site 1183438004628 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438004629 Condensation domain; Region: Condensation; pfam00668 1183438004630 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1183438004631 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1183438004632 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1183438004633 acyl-activating enzyme (AAE) consensus motif; other site 1183438004634 AMP binding site [chemical binding]; other site 1183438004635 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438004636 Condensation domain; Region: Condensation; pfam00668 1183438004637 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1183438004638 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1183438004639 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1183438004640 acyl-activating enzyme (AAE) consensus motif; other site 1183438004641 AMP binding site [chemical binding]; other site 1183438004642 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438004643 Condensation domain; Region: Condensation; pfam00668 1183438004644 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1183438004645 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1183438004646 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1183438004647 acyl-activating enzyme (AAE) consensus motif; other site 1183438004648 AMP binding site [chemical binding]; other site 1183438004649 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438004650 Condensation domain; Region: Condensation; pfam00668 1183438004651 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1183438004652 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1183438004653 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1183438004654 acyl-activating enzyme (AAE) consensus motif; other site 1183438004655 AMP binding site [chemical binding]; other site 1183438004656 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438004657 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438004658 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438004659 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438004660 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1183438004661 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1183438004662 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1183438004663 acyl-activating enzyme (AAE) consensus motif; other site 1183438004664 AMP binding site [chemical binding]; other site 1183438004665 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1183438004666 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1183438004667 acyl-activating enzyme (AAE) consensus motif; other site 1183438004668 AMP binding site [chemical binding]; other site 1183438004669 active site 1183438004670 CoA binding site [chemical binding]; other site 1183438004671 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1183438004672 putative NADP binding site [chemical binding]; other site 1183438004673 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1183438004674 active site 1183438004675 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438004676 Condensation domain; Region: Condensation; pfam00668 1183438004677 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1183438004678 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1183438004679 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1183438004680 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1183438004681 active site 1183438004682 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1183438004683 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1183438004684 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1183438004685 active site 1183438004686 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1183438004687 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1183438004688 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1183438004689 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1183438004690 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1183438004691 KR domain; Region: KR; pfam08659 1183438004692 putative NADP binding site [chemical binding]; other site 1183438004693 active site 1183438004694 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1183438004695 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1183438004696 Enoylreductase; Region: PKS_ER; smart00829 1183438004697 NAD(P) binding site [chemical binding]; other site 1183438004698 acyl carrier protein; Validated; Region: PRK07117 1183438004699 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1183438004700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1183438004701 substrate binding site [chemical binding]; other site 1183438004702 oxyanion hole (OAH) forming residues; other site 1183438004703 trimer interface [polypeptide binding]; other site 1183438004704 enoyl-CoA hydratase; Provisional; Region: PRK05995 1183438004705 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1183438004706 substrate binding site [chemical binding]; other site 1183438004707 oxyanion hole (OAH) forming residues; other site 1183438004708 trimer interface [polypeptide binding]; other site 1183438004709 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1183438004710 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1183438004711 dimer interface [polypeptide binding]; other site 1183438004712 active site 1183438004713 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1183438004714 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1183438004715 active site 1183438004716 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1183438004717 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1183438004718 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1183438004719 active site 1183438004720 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1183438004721 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1183438004722 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1183438004723 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1183438004724 putative NADP binding site [chemical binding]; other site 1183438004725 active site 1183438004726 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1183438004727 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1183438004728 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1183438004729 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1183438004730 acyl-activating enzyme (AAE) consensus motif; other site 1183438004731 AMP binding site [chemical binding]; other site 1183438004732 active site 1183438004733 CoA binding site [chemical binding]; other site 1183438004734 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1183438004735 KR domain; Region: KR; pfam08659 1183438004736 putative NADP binding site [chemical binding]; other site 1183438004737 active site 1183438004738 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438004739 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1183438004740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1183438004741 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 1183438004742 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1183438004743 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1183438004744 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1183438004745 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1183438004746 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438004747 catalytic residue [active] 1183438004748 phytoene desaturase; Region: crtI_fam; TIGR02734 1183438004749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438004750 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1183438004751 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1183438004752 AIPR protein; Region: AIPR; pfam10592 1183438004753 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438004754 putative active site [active] 1183438004755 calcium/proton exchanger (cax); Region: cax; TIGR00378 1183438004756 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1183438004757 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1183438004758 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1183438004759 ATP cone domain; Region: ATP-cone; pfam03477 1183438004760 mercuric reductase; Validated; Region: PRK06370 1183438004761 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1183438004762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438004763 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1183438004764 alpha-glucosidase; Provisional; Region: PRK10137 1183438004765 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1183438004766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438004767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438004768 active site 1183438004769 phosphorylation site [posttranslational modification] 1183438004770 intermolecular recognition site; other site 1183438004771 dimerization interface [polypeptide binding]; other site 1183438004772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438004773 DNA binding site [nucleotide binding] 1183438004774 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1183438004775 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1183438004776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438004777 dimer interface [polypeptide binding]; other site 1183438004778 phosphorylation site [posttranslational modification] 1183438004779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438004780 ATP binding site [chemical binding]; other site 1183438004781 Mg2+ binding site [ion binding]; other site 1183438004782 G-X-G motif; other site 1183438004783 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1183438004784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438004785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438004786 DNA binding residues [nucleotide binding] 1183438004787 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1183438004788 heterotetramer interface [polypeptide binding]; other site 1183438004789 active site pocket [active] 1183438004790 cleavage site 1183438004791 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1183438004792 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1183438004793 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1183438004794 Chain length determinant protein; Region: Wzz; pfam02706 1183438004795 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1183438004796 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1183438004797 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1183438004798 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1183438004799 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438004800 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438004801 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1183438004802 SelR domain; Region: SelR; pfam01641 1183438004803 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1183438004804 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1183438004805 active site 1183438004806 Zn binding site [ion binding]; other site 1183438004807 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1183438004808 thiamine monophosphate kinase; Provisional; Region: PRK05731 1183438004809 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1183438004810 ATP binding site [chemical binding]; other site 1183438004811 dimerization interface [polypeptide binding]; other site 1183438004812 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 1183438004813 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1183438004814 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1183438004815 active site 1183438004816 putative DNA-binding cleft [nucleotide binding]; other site 1183438004817 dimer interface [polypeptide binding]; other site 1183438004818 Bacterial Ig-like domain; Region: Big_5; pfam13205 1183438004819 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1183438004820 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1183438004821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438004822 POT family; Region: PTR2; cl17359 1183438004823 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1183438004824 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1183438004825 Caspase domain; Region: Peptidase_C14; pfam00656 1183438004826 AAA ATPase domain; Region: AAA_16; pfam13191 1183438004827 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438004828 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438004829 structural tetrad; other site 1183438004830 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438004831 structural tetrad; other site 1183438004832 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1183438004833 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1183438004834 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1183438004835 dimer interface [polypeptide binding]; other site 1183438004836 active site 1183438004837 heme binding site [chemical binding]; other site 1183438004838 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1183438004839 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1183438004840 metal binding site 2 [ion binding]; metal-binding site 1183438004841 putative DNA binding helix; other site 1183438004842 metal binding site 1 [ion binding]; metal-binding site 1183438004843 dimer interface [polypeptide binding]; other site 1183438004844 structural Zn2+ binding site [ion binding]; other site 1183438004845 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 1183438004846 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1183438004847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1183438004848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1183438004849 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1183438004850 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1183438004851 active site 1183438004852 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1183438004853 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1183438004854 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1183438004855 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438004856 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438004857 active site 1183438004858 catalytic tetrad [active] 1183438004859 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1183438004860 MgtE intracellular N domain; Region: MgtE_N; smart00924 1183438004861 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1183438004862 Divalent cation transporter; Region: MgtE; pfam01769 1183438004863 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438004864 putative active site [active] 1183438004865 putative catalytic triad [active] 1183438004866 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1183438004867 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1183438004868 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1183438004869 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1183438004870 cobalamin binding residues [chemical binding]; other site 1183438004871 putative BtuC binding residues; other site 1183438004872 dimer interface [polypeptide binding]; other site 1183438004873 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1183438004874 Antitoxin ParD; Region: ParD; pfam09386 1183438004875 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1183438004876 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1183438004877 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1183438004878 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 1183438004879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1183438004880 RNA binding surface [nucleotide binding]; other site 1183438004881 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1183438004882 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1183438004883 active site 1183438004884 substrate binding site [chemical binding]; other site 1183438004885 metal binding site [ion binding]; metal-binding site 1183438004886 Deoxyhypusine synthase; Region: DS; cl00826 1183438004887 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1183438004888 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1183438004889 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1183438004890 glutaminase A; Region: Gln_ase; TIGR03814 1183438004891 TPR repeat; Region: TPR_11; pfam13414 1183438004892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438004893 binding surface 1183438004894 TPR motif; other site 1183438004895 TPR repeat; Region: TPR_11; pfam13414 1183438004896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1183438004897 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1183438004898 extended (e) SDRs; Region: SDR_e; cd08946 1183438004899 NAD(P) binding site [chemical binding]; other site 1183438004900 active site 1183438004901 substrate binding site [chemical binding]; other site 1183438004902 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1183438004903 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1183438004904 inhibitor-cofactor binding pocket; inhibition site 1183438004905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438004906 catalytic residue [active] 1183438004907 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1183438004908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438004909 NAD(P) binding site [chemical binding]; other site 1183438004910 active site 1183438004911 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1183438004912 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1183438004913 substrate binding site; other site 1183438004914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438004915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438004916 active site 1183438004917 phosphorylation site [posttranslational modification] 1183438004918 intermolecular recognition site; other site 1183438004919 dimerization interface [polypeptide binding]; other site 1183438004920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438004921 DNA binding site [nucleotide binding] 1183438004922 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1183438004923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438004924 dimerization interface [polypeptide binding]; other site 1183438004925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438004926 dimer interface [polypeptide binding]; other site 1183438004927 phosphorylation site [posttranslational modification] 1183438004928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438004929 ATP binding site [chemical binding]; other site 1183438004930 Mg2+ binding site [ion binding]; other site 1183438004931 G-X-G motif; other site 1183438004932 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1183438004933 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1183438004934 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1183438004935 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438004936 active site 1183438004937 metal binding site [ion binding]; metal-binding site 1183438004938 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1183438004939 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438004940 putative catalytic residue [active] 1183438004941 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1183438004942 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1183438004943 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1183438004944 protein binding site [polypeptide binding]; other site 1183438004945 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1183438004946 tryptophan-rich conserved hypothetical protein; Region: TIGR02450 1183438004947 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1183438004948 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1183438004949 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1183438004950 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1183438004951 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1183438004952 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1183438004953 dimerization interface 3.5A [polypeptide binding]; other site 1183438004954 active site 1183438004955 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1183438004956 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1183438004957 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1183438004958 alphaNTD - beta interaction site [polypeptide binding]; other site 1183438004959 alphaNTD homodimer interface [polypeptide binding]; other site 1183438004960 alphaNTD - beta' interaction site [polypeptide binding]; other site 1183438004961 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1183438004962 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1183438004963 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1183438004964 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1183438004965 RNA binding surface [nucleotide binding]; other site 1183438004966 30S ribosomal protein S11; Validated; Region: PRK05309 1183438004967 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1183438004968 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1183438004969 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1183438004970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438004971 binding surface 1183438004972 TPR motif; other site 1183438004973 TPR repeat; Region: TPR_11; pfam13414 1183438004974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438004975 binding surface 1183438004976 TPR repeat; Region: TPR_11; pfam13414 1183438004977 TPR motif; other site 1183438004978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438004979 binding surface 1183438004980 TPR repeat; Region: TPR_11; pfam13414 1183438004981 TPR motif; other site 1183438004982 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1183438004983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438004984 S-adenosylmethionine binding site [chemical binding]; other site 1183438004985 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1183438004986 Clp amino terminal domain; Region: Clp_N; pfam02861 1183438004987 Clp amino terminal domain; Region: Clp_N; pfam02861 1183438004988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004989 Walker A motif; other site 1183438004990 ATP binding site [chemical binding]; other site 1183438004991 Walker B motif; other site 1183438004992 arginine finger; other site 1183438004993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438004994 Walker A motif; other site 1183438004995 ATP binding site [chemical binding]; other site 1183438004996 Walker B motif; other site 1183438004997 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1183438004998 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1183438004999 active site 1183438005000 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1183438005001 active site 1183438005002 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1183438005003 Transcriptional regulator; Region: Rrf2; pfam02082 1183438005004 Transcriptional regulator; Region: Rrf2; cl17282 1183438005005 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1183438005006 putative ABC transporter; Region: ycf24; CHL00085 1183438005007 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1183438005008 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1183438005009 Walker A/P-loop; other site 1183438005010 ATP binding site [chemical binding]; other site 1183438005011 Q-loop/lid; other site 1183438005012 ABC transporter signature motif; other site 1183438005013 Walker B; other site 1183438005014 D-loop; other site 1183438005015 H-loop/switch region; other site 1183438005016 FeS assembly protein SufD; Region: sufD; TIGR01981 1183438005017 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1183438005018 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1183438005019 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1183438005020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438005021 catalytic residue [active] 1183438005022 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1183438005023 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1183438005024 trimerization site [polypeptide binding]; other site 1183438005025 active site 1183438005026 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1183438005027 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1183438005028 Predicted ATPase [General function prediction only]; Region: COG3903 1183438005029 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438005030 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1183438005031 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1183438005032 conserved cys residue [active] 1183438005033 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1183438005034 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1183438005035 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1183438005036 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1183438005037 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438005038 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 1183438005039 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1183438005040 putative active site pocket [active] 1183438005041 4-fold oligomerization interface [polypeptide binding]; other site 1183438005042 metal binding residues [ion binding]; metal-binding site 1183438005043 3-fold/trimer interface [polypeptide binding]; other site 1183438005044 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1183438005045 peptidase domain interface [polypeptide binding]; other site 1183438005046 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1183438005047 active site 1183438005048 catalytic triad [active] 1183438005049 calcium binding site [ion binding]; other site 1183438005050 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1183438005051 Peptidase family M48; Region: Peptidase_M48; cl12018 1183438005052 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1183438005053 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1183438005054 dimer interface [polypeptide binding]; other site 1183438005055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438005056 catalytic residue [active] 1183438005057 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1183438005058 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1183438005059 NADP-binding site; other site 1183438005060 homotetramer interface [polypeptide binding]; other site 1183438005061 substrate binding site [chemical binding]; other site 1183438005062 homodimer interface [polypeptide binding]; other site 1183438005063 active site 1183438005064 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1183438005065 oligomerization interface [polypeptide binding]; other site 1183438005066 active site 1183438005067 metal binding site [ion binding]; metal-binding site 1183438005068 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1183438005069 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1183438005070 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1183438005071 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1183438005072 23S rRNA interface [nucleotide binding]; other site 1183438005073 L7/L12 interface [polypeptide binding]; other site 1183438005074 putative thiostrepton binding site; other site 1183438005075 L25 interface [polypeptide binding]; other site 1183438005076 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1183438005077 mRNA/rRNA interface [nucleotide binding]; other site 1183438005078 ribosomal protein L10 leader 1183438005079 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1183438005080 23S rRNA interface [nucleotide binding]; other site 1183438005081 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1183438005082 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1183438005083 L11 interface [polypeptide binding]; other site 1183438005084 putative EF-Tu interaction site [polypeptide binding]; other site 1183438005085 putative EF-G interaction site [polypeptide binding]; other site 1183438005086 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1183438005087 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1183438005088 active site 1183438005089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005090 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438005091 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005092 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005093 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005094 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1183438005095 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005096 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005097 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005098 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005099 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005100 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438005101 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005102 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005103 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005104 HEAT repeats; Region: HEAT_2; pfam13646 1183438005105 HEAT repeats; Region: HEAT_2; pfam13646 1183438005106 WYL domain; Region: WYL; pfam13280 1183438005107 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1183438005108 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 1183438005109 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 1183438005110 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 1183438005111 CRISPR type I-D/CYANO-associated protein Csc2; Region: cas_Csc2; TIGR03157 1183438005112 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 1183438005113 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 1183438005114 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1183438005115 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1183438005116 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1183438005117 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1183438005118 Fic family protein [Function unknown]; Region: COG3177 1183438005119 Fic/DOC family; Region: Fic; pfam02661 1183438005120 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1183438005121 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1183438005122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1183438005123 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1183438005124 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1183438005125 active site 1183438005126 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1183438005127 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1183438005128 active site 1183438005129 homodimer interface [polypeptide binding]; other site 1183438005130 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1183438005131 GAF domain; Region: GAF_3; pfam13492 1183438005132 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1183438005133 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1183438005134 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 1183438005135 Na binding site [ion binding]; other site 1183438005136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438005137 non-specific DNA binding site [nucleotide binding]; other site 1183438005138 salt bridge; other site 1183438005139 sequence-specific DNA binding site [nucleotide binding]; other site 1183438005140 Domain of unknown function (DUF955); Region: DUF955; cl01076 1183438005141 MgtC family; Region: MgtC; pfam02308 1183438005142 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1183438005143 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1183438005144 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1183438005145 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1183438005146 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438005147 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1183438005148 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1183438005149 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 1183438005150 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1183438005151 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1183438005152 proposed catalytic triad [active] 1183438005153 conserved cys residue [active] 1183438005154 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1183438005155 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1183438005156 DXD motif; other site 1183438005157 TIGR02652 family protein; Region: TIGR02652 1183438005158 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1183438005159 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1183438005160 dimer interface [polypeptide binding]; other site 1183438005161 motif 1; other site 1183438005162 active site 1183438005163 motif 2; other site 1183438005164 motif 3; other site 1183438005165 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1183438005166 anticodon binding site; other site 1183438005167 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1183438005168 active site 1183438005169 ribulose/triose binding site [chemical binding]; other site 1183438005170 phosphate binding site [ion binding]; other site 1183438005171 substrate (anthranilate) binding pocket [chemical binding]; other site 1183438005172 product (indole) binding pocket [chemical binding]; other site 1183438005173 HEAT repeats; Region: HEAT_2; pfam13646 1183438005174 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 1183438005175 arginine decarboxylase; Provisional; Region: PRK05354 1183438005176 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1183438005177 dimer interface [polypeptide binding]; other site 1183438005178 active site 1183438005179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1183438005180 catalytic residues [active] 1183438005181 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1183438005182 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1183438005183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438005184 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1183438005185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438005186 active site 1183438005187 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1183438005188 substrate binding site; other site 1183438005189 dimer interface; other site 1183438005190 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 1183438005191 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1183438005192 hypothetical protein; Reviewed; Region: PRK00024 1183438005193 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1183438005194 MPN+ (JAMM) motif; other site 1183438005195 Zinc-binding site [ion binding]; other site 1183438005196 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1183438005197 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1183438005198 N-terminal plug; other site 1183438005199 ligand-binding site [chemical binding]; other site 1183438005200 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 1183438005201 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1183438005202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438005203 homodimer interface [polypeptide binding]; other site 1183438005204 catalytic residue [active] 1183438005205 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1183438005206 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1183438005207 cell division protein FtsW; Region: ftsW; TIGR02614 1183438005208 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1183438005209 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438005210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438005211 binding surface 1183438005212 TPR motif; other site 1183438005213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438005214 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438005215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438005216 binding surface 1183438005217 TPR motif; other site 1183438005218 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438005219 CHAT domain; Region: CHAT; pfam12770 1183438005220 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438005221 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005222 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005223 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438005224 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005225 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438005226 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1183438005227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438005228 Walker A motif; other site 1183438005229 ATP binding site [chemical binding]; other site 1183438005230 Walker B motif; other site 1183438005231 arginine finger; other site 1183438005232 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1183438005233 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1183438005234 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438005235 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438005236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438005237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438005238 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438005239 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1183438005240 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1183438005241 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1183438005242 active site 1183438005243 Zn binding site [ion binding]; other site 1183438005244 Thioredoxin; Region: Thioredoxin_4; pfam13462 1183438005245 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1183438005246 PAS domain S-box; Region: sensory_box; TIGR00229 1183438005247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438005248 putative active site [active] 1183438005249 heme pocket [chemical binding]; other site 1183438005250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438005251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438005252 dimer interface [polypeptide binding]; other site 1183438005253 phosphorylation site [posttranslational modification] 1183438005254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438005255 ATP binding site [chemical binding]; other site 1183438005256 Mg2+ binding site [ion binding]; other site 1183438005257 G-X-G motif; other site 1183438005258 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 1183438005259 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1183438005260 DNA binding residues [nucleotide binding] 1183438005261 dimer interface [polypeptide binding]; other site 1183438005262 metal binding site [ion binding]; metal-binding site 1183438005263 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1183438005264 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1183438005265 metal-binding site [ion binding] 1183438005266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1183438005267 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1183438005268 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1183438005269 Outer membrane efflux protein; Region: OEP; pfam02321 1183438005270 Outer membrane efflux protein; Region: OEP; pfam02321 1183438005271 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438005272 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1183438005273 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438005274 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438005275 Peptidase family M48; Region: Peptidase_M48; cl12018 1183438005276 Penicillinase repressor; Region: Pencillinase_R; cl17580 1183438005277 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438005278 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438005279 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438005280 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438005281 Outer membrane efflux protein; Region: OEP; pfam02321 1183438005282 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1183438005283 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1183438005284 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1183438005285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1183438005286 dimerization interface [polypeptide binding]; other site 1183438005287 putative DNA binding site [nucleotide binding]; other site 1183438005288 putative Zn2+ binding site [ion binding]; other site 1183438005289 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1183438005290 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438005291 active site 1183438005292 metal binding site [ion binding]; metal-binding site 1183438005293 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1183438005294 amphipathic channel; other site 1183438005295 Asn-Pro-Ala signature motifs; other site 1183438005296 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1183438005297 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1183438005298 active site 1183438005299 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438005300 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438005301 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438005302 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438005303 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1183438005304 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1183438005305 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1183438005306 FG-GAP repeat; Region: FG-GAP; pfam01839 1183438005307 Family description; Region: VCBS; pfam13517 1183438005308 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1183438005309 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1183438005310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438005311 motif II; other site 1183438005312 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1183438005313 dimerization interface [polypeptide binding]; other site 1183438005314 putative DNA binding site [nucleotide binding]; other site 1183438005315 putative Zn2+ binding site [ion binding]; other site 1183438005316 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1183438005317 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1183438005318 oligomeric interface; other site 1183438005319 homodimer interface [polypeptide binding]; other site 1183438005320 putative active site [active] 1183438005321 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1183438005322 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1183438005323 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1183438005324 putative NADP binding site [chemical binding]; other site 1183438005325 putative substrate binding site [chemical binding]; other site 1183438005326 active site 1183438005327 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1183438005328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438005329 FeS/SAM binding site; other site 1183438005330 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1183438005331 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1183438005332 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1183438005333 tetramer interface [polypeptide binding]; other site 1183438005334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438005335 catalytic residue [active] 1183438005336 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1183438005337 active site 1183438005338 RNA/DNA hybrid binding site [nucleotide binding]; other site 1183438005339 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1183438005340 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1183438005341 PhoH-like protein; Region: PhoH; pfam02562 1183438005342 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438005343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438005344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438005345 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438005346 MarC family integral membrane protein; Region: MarC; cl00919 1183438005347 DNA topoisomerase I; Validated; Region: PRK05582 1183438005348 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1183438005349 active site 1183438005350 interdomain interaction site; other site 1183438005351 putative metal-binding site [ion binding]; other site 1183438005352 nucleotide binding site [chemical binding]; other site 1183438005353 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1183438005354 domain I; other site 1183438005355 DNA binding groove [nucleotide binding] 1183438005356 phosphate binding site [ion binding]; other site 1183438005357 domain II; other site 1183438005358 domain III; other site 1183438005359 nucleotide binding site [chemical binding]; other site 1183438005360 catalytic site [active] 1183438005361 domain IV; other site 1183438005362 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1183438005363 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1183438005364 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1183438005365 tellurium resistance terB-like protein; Region: terB_like; cd07177 1183438005366 metal binding site [ion binding]; metal-binding site 1183438005367 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1183438005368 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 1183438005369 apical/protease domain interface [polypeptide binding]; other site 1183438005370 substrate binding [chemical binding]; other site 1183438005371 dimer interface [polypeptide binding]; other site 1183438005372 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 1183438005373 dimer interface [polypeptide binding]; other site 1183438005374 Peptidase family M28; Region: Peptidase_M28; pfam04389 1183438005375 active site 1183438005376 metal binding site [ion binding]; metal-binding site 1183438005377 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 1183438005378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438005379 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438005380 leucyl-tRNA synthetase, archaeal and cytosolic family; Region: leuS_arch; TIGR00395 1183438005381 phosphoglyceromutase; Provisional; Region: PRK05434 1183438005382 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1183438005383 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1183438005384 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1183438005385 trimer interface [polypeptide binding]; other site 1183438005386 putative metal binding site [ion binding]; other site 1183438005387 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1183438005388 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1183438005389 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1183438005390 Cupin domain; Region: Cupin_2; cl17218 1183438005391 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1183438005392 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1183438005393 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1183438005394 active site 1183438005395 YceI-like domain; Region: YceI; cl01001 1183438005396 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1183438005397 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1183438005398 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438005399 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1183438005400 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1183438005401 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1183438005402 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1183438005403 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 1183438005404 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1183438005405 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1183438005406 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1183438005407 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1183438005408 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1183438005409 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1183438005410 putative active site [active] 1183438005411 putative dimer interface [polypeptide binding]; other site 1183438005412 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1183438005413 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1183438005414 nudix motif; other site 1183438005415 biotin synthase; Region: bioB; TIGR00433 1183438005416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438005417 FeS/SAM binding site; other site 1183438005418 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1183438005419 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1183438005420 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 1183438005421 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438005422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438005423 DNA binding residues [nucleotide binding] 1183438005424 dimerization interface [polypeptide binding]; other site 1183438005425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1183438005426 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1183438005427 NurA nuclease; Region: NurA; smart00933 1183438005428 CsbD-like; Region: CsbD; pfam05532 1183438005429 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1183438005430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438005431 Walker A/P-loop; other site 1183438005432 ATP binding site [chemical binding]; other site 1183438005433 Q-loop/lid; other site 1183438005434 ABC transporter signature motif; other site 1183438005435 Walker B; other site 1183438005436 D-loop; other site 1183438005437 H-loop/switch region; other site 1183438005438 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1183438005439 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1183438005440 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1183438005441 generic binding surface II; other site 1183438005442 ssDNA binding site; other site 1183438005443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438005444 ATP binding site [chemical binding]; other site 1183438005445 putative Mg++ binding site [ion binding]; other site 1183438005446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438005447 nucleotide binding region [chemical binding]; other site 1183438005448 ATP-binding site [chemical binding]; other site 1183438005449 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1183438005450 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1183438005451 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1183438005452 nucleotide binding site [chemical binding]; other site 1183438005453 NEF interaction site [polypeptide binding]; other site 1183438005454 SBD interface [polypeptide binding]; other site 1183438005455 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 1183438005456 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1183438005457 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1183438005458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1183438005459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1183438005460 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1183438005461 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1183438005462 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1183438005463 conserved cys residue [active] 1183438005464 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1183438005465 NmrA-like family; Region: NmrA; pfam05368 1183438005466 NADP binding site [chemical binding]; other site 1183438005467 active site 1183438005468 regulatory binding site [polypeptide binding]; other site 1183438005469 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1183438005470 Stage II sporulation protein; Region: SpoIID; pfam08486 1183438005471 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1183438005472 active site 1183438005473 CAAX protease self-immunity; Region: Abi; cl00558 1183438005474 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1183438005475 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1183438005476 substrate binding pocket [chemical binding]; other site 1183438005477 chain length determination region; other site 1183438005478 substrate-Mg2+ binding site; other site 1183438005479 catalytic residues [active] 1183438005480 aspartate-rich region 1; other site 1183438005481 active site lid residues [active] 1183438005482 aspartate-rich region 2; other site 1183438005483 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1183438005484 intersubunit interface [polypeptide binding]; other site 1183438005485 active site 1183438005486 zinc binding site [ion binding]; other site 1183438005487 Na+ binding site [ion binding]; other site 1183438005488 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1183438005489 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1183438005490 Walker A/P-loop; other site 1183438005491 ATP binding site [chemical binding]; other site 1183438005492 Q-loop/lid; other site 1183438005493 ABC transporter signature motif; other site 1183438005494 Walker B; other site 1183438005495 D-loop; other site 1183438005496 H-loop/switch region; other site 1183438005497 mce related protein; Region: MCE; pfam02470 1183438005498 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 1183438005499 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1183438005500 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1183438005501 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1183438005502 OstA-like protein; Region: OstA; cl00844 1183438005503 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 1183438005504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438005505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438005506 dimer interface [polypeptide binding]; other site 1183438005507 phosphorylation site [posttranslational modification] 1183438005508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438005509 ATP binding site [chemical binding]; other site 1183438005510 Mg2+ binding site [ion binding]; other site 1183438005511 G-X-G motif; other site 1183438005512 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438005513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438005514 active site 1183438005515 phosphorylation site [posttranslational modification] 1183438005516 intermolecular recognition site; other site 1183438005517 dimerization interface [polypeptide binding]; other site 1183438005518 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1183438005519 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1183438005520 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438005521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438005522 putative active site [active] 1183438005523 heme pocket [chemical binding]; other site 1183438005524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438005525 dimer interface [polypeptide binding]; other site 1183438005526 phosphorylation site [posttranslational modification] 1183438005527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438005528 ATP binding site [chemical binding]; other site 1183438005529 Mg2+ binding site [ion binding]; other site 1183438005530 G-X-G motif; other site 1183438005531 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1183438005532 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1183438005533 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1183438005534 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1183438005535 IHF dimer interface [polypeptide binding]; other site 1183438005536 IHF - DNA interface [nucleotide binding]; other site 1183438005537 TolA protein; Region: tolA_full; TIGR02794 1183438005538 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1183438005539 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1183438005540 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1183438005541 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1183438005542 active site 1183438005543 Riboflavin kinase; Region: Flavokinase; pfam01687 1183438005544 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 1183438005545 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1183438005546 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438005547 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 1183438005548 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438005549 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1183438005550 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1183438005551 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1183438005552 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1183438005553 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1183438005554 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1183438005555 active site 1183438005556 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1183438005557 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1183438005558 active site 1183438005559 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1183438005560 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1183438005561 active site 1183438005562 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1183438005563 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438005564 putative trimer interface [polypeptide binding]; other site 1183438005565 putative CoA binding site [chemical binding]; other site 1183438005566 putative acyl transferase; Provisional; Region: PRK10502 1183438005567 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1183438005568 putative trimer interface [polypeptide binding]; other site 1183438005569 putative active site [active] 1183438005570 putative substrate binding site [chemical binding]; other site 1183438005571 putative CoA binding site [chemical binding]; other site 1183438005572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438005573 S-adenosylmethionine binding site [chemical binding]; other site 1183438005574 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1183438005575 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1183438005576 active site 1183438005577 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1183438005578 active site 1183438005579 metal-binding site [ion binding] 1183438005580 nucleotide-binding site [chemical binding]; other site 1183438005581 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1183438005582 dimer interface [polypeptide binding]; other site 1183438005583 active site 1183438005584 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1183438005585 Ligand Binding Site [chemical binding]; other site 1183438005586 Molecular Tunnel; other site 1183438005587 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1183438005588 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1183438005589 putative metal binding site; other site 1183438005590 putative glycosyl transferase; Provisional; Region: PRK10307 1183438005591 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1183438005592 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1183438005593 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1183438005594 putative active site [active] 1183438005595 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438005596 putative active site [active] 1183438005597 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1183438005598 RES domain; Region: RES; cl02411 1183438005599 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1183438005600 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1183438005601 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1183438005602 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1183438005603 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1183438005604 Walker A motif; other site 1183438005605 ATP binding site [chemical binding]; other site 1183438005606 Walker B motif; other site 1183438005607 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1183438005608 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1183438005609 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1183438005610 Walker A motif; other site 1183438005611 ATP binding site [chemical binding]; other site 1183438005612 Walker B motif; other site 1183438005613 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1183438005614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438005615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438005616 DNA binding residues [nucleotide binding] 1183438005617 Ycf27; Reviewed; Region: orf27; CHL00148 1183438005618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438005619 active site 1183438005620 phosphorylation site [posttranslational modification] 1183438005621 intermolecular recognition site; other site 1183438005622 dimerization interface [polypeptide binding]; other site 1183438005623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438005624 DNA binding site [nucleotide binding] 1183438005625 BNR repeat-like domain; Region: BNR_2; pfam13088 1183438005626 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1183438005627 Asp-box motif; other site 1183438005628 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438005629 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1183438005630 active site 1183438005631 ATP binding site [chemical binding]; other site 1183438005632 substrate binding site [chemical binding]; other site 1183438005633 activation loop (A-loop); other site 1183438005634 Predicted integral membrane protein [Function unknown]; Region: COG5616 1183438005635 TPR repeat; Region: TPR_11; pfam13414 1183438005636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438005637 binding surface 1183438005638 TPR motif; other site 1183438005639 TPR repeat; Region: TPR_11; pfam13414 1183438005640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438005641 binding surface 1183438005642 TPR motif; other site 1183438005643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438005644 binding surface 1183438005645 TPR motif; other site 1183438005646 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 1183438005647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438005648 DNA binding residues [nucleotide binding] 1183438005649 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438005650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438005651 S-adenosylmethionine binding site [chemical binding]; other site 1183438005652 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1183438005653 Fasciclin domain; Region: Fasciclin; pfam02469 1183438005654 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1183438005655 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1183438005656 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1183438005657 dimerization interface [polypeptide binding]; other site 1183438005658 DPS ferroxidase diiron center [ion binding]; other site 1183438005659 ion pore; other site 1183438005660 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1183438005661 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1183438005662 NAD binding site [chemical binding]; other site 1183438005663 homodimer interface [polypeptide binding]; other site 1183438005664 active site 1183438005665 substrate binding site [chemical binding]; other site 1183438005666 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1183438005667 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438005668 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438005669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438005670 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1183438005671 Walker A/P-loop; other site 1183438005672 ATP binding site [chemical binding]; other site 1183438005673 ABC transporter signature motif; other site 1183438005674 Walker B; other site 1183438005675 D-loop; other site 1183438005676 H-loop/switch region; other site 1183438005677 Condensation domain; Region: Condensation; pfam00668 1183438005678 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1183438005679 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1183438005680 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1183438005681 acyl-activating enzyme (AAE) consensus motif; other site 1183438005682 AMP binding site [chemical binding]; other site 1183438005683 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1183438005684 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1183438005685 anthranilate synthase component I-like protein; Validated; Region: PRK05940 1183438005686 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1183438005687 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1183438005688 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1183438005689 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1183438005690 active site 1183438005691 HIGH motif; other site 1183438005692 dimer interface [polypeptide binding]; other site 1183438005693 KMSKS motif; other site 1183438005694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1183438005695 RNA binding surface [nucleotide binding]; other site 1183438005696 Protein of function (DUF2518); Region: DUF2518; pfam10726 1183438005697 BolA-like protein; Region: BolA; pfam01722 1183438005698 WYL domain; Region: WYL; cl14852 1183438005699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438005700 AAA domain; Region: AAA_21; pfam13304 1183438005701 Walker A/P-loop; other site 1183438005702 ATP binding site [chemical binding]; other site 1183438005703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438005704 Walker B; other site 1183438005705 D-loop; other site 1183438005706 H-loop/switch region; other site 1183438005707 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438005708 putative active site [active] 1183438005709 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1183438005710 23S rRNA interface [nucleotide binding]; other site 1183438005711 L3 interface [polypeptide binding]; other site 1183438005712 ribosomal protein S9; Region: rps9; CHL00079 1183438005713 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1183438005714 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1183438005715 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1183438005716 RF-1 domain; Region: RF-1; pfam00472 1183438005717 GTPase Era; Reviewed; Region: era; PRK00089 1183438005718 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1183438005719 G1 box; other site 1183438005720 GTP/Mg2+ binding site [chemical binding]; other site 1183438005721 Switch I region; other site 1183438005722 G2 box; other site 1183438005723 Switch II region; other site 1183438005724 G3 box; other site 1183438005725 G4 box; other site 1183438005726 G5 box; other site 1183438005727 KH domain; Region: KH_2; pfam07650 1183438005728 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1183438005729 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1183438005730 ATP binding site [chemical binding]; other site 1183438005731 active site 1183438005732 substrate binding site [chemical binding]; other site 1183438005733 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 1183438005734 Haemolytic domain; Region: Haemolytic; pfam01809 1183438005735 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 1183438005736 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1183438005737 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1183438005738 ligand binding site [chemical binding]; other site 1183438005739 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1183438005740 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1183438005741 phosphopeptide binding site; other site 1183438005742 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1183438005743 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1183438005744 catalytic core [active] 1183438005745 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1183438005746 catalytic core [active] 1183438005747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438005748 binding surface 1183438005749 TPR motif; other site 1183438005750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438005751 binding surface 1183438005752 TPR motif; other site 1183438005753 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438005754 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1183438005755 FtsX-like permease family; Region: FtsX; pfam02687 1183438005756 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438005757 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438005758 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438005759 putative membrane fusion protein; Region: TIGR02828 1183438005760 FO synthase subunit 2; Reviewed; Region: PRK07360 1183438005761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438005762 FeS/SAM binding site; other site 1183438005763 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1183438005764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438005765 active site 1183438005766 motif I; other site 1183438005767 motif II; other site 1183438005768 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1183438005769 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438005770 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1183438005771 protein I interface; other site 1183438005772 D2 interface; other site 1183438005773 protein T interface; other site 1183438005774 chlorophyll binding site; other site 1183438005775 beta carotene binding site; other site 1183438005776 pheophytin binding site; other site 1183438005777 manganese-stabilizing polypeptide interface; other site 1183438005778 CP43 interface; other site 1183438005779 protein L interface; other site 1183438005780 oxygen evolving complex binding site; other site 1183438005781 bromide binding site; other site 1183438005782 quinone binding site; other site 1183438005783 Fe binding site [ion binding]; other site 1183438005784 core light harvesting interface; other site 1183438005785 cytochrome b559 alpha subunit interface; other site 1183438005786 cytochrome c-550 interface; other site 1183438005787 protein J interface; other site 1183438005788 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 1183438005789 active site 1183438005790 Zn binding site [ion binding]; other site 1183438005791 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1183438005792 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1183438005793 Domain of unknown function DUF302; Region: DUF302; pfam03625 1183438005794 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1183438005795 putative dimer interface [polypeptide binding]; other site 1183438005796 active site pocket [active] 1183438005797 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1183438005798 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1183438005799 ligand binding site [chemical binding]; other site 1183438005800 flexible hinge region; other site 1183438005801 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1183438005802 putative switch regulator; other site 1183438005803 non-specific DNA interactions [nucleotide binding]; other site 1183438005804 DNA binding site [nucleotide binding] 1183438005805 sequence specific DNA binding site [nucleotide binding]; other site 1183438005806 putative cAMP binding site [chemical binding]; other site 1183438005807 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1183438005808 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1183438005809 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1183438005810 beta subunit interaction interface [polypeptide binding]; other site 1183438005811 Walker A motif; other site 1183438005812 ATP binding site [chemical binding]; other site 1183438005813 Walker B motif; other site 1183438005814 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1183438005815 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1183438005816 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1183438005817 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1183438005818 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 1183438005819 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 1183438005820 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1183438005821 F0F1 ATP synthase subunit C; Validated; Region: PRK07354 1183438005822 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1183438005823 ATP synthase CF0 A subunit; Region: atpI; CHL00046 1183438005824 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1183438005825 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1183438005826 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1183438005827 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1183438005828 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1183438005829 active site 1183438005830 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1183438005831 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1183438005832 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1183438005833 active site 1183438005834 HIGH motif; other site 1183438005835 nucleotide binding site [chemical binding]; other site 1183438005836 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1183438005837 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1183438005838 active site 1183438005839 KMSKS motif; other site 1183438005840 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1183438005841 tRNA binding surface [nucleotide binding]; other site 1183438005842 anticodon binding site; other site 1183438005843 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1183438005844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438005845 S-adenosylmethionine binding site [chemical binding]; other site 1183438005846 HNH endonuclease; Region: HNH; pfam01844 1183438005847 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1183438005848 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1183438005849 putative di-iron ligands [ion binding]; other site 1183438005850 magnesium chelatase subunit H; Provisional; Region: PRK12493 1183438005851 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 1183438005852 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1183438005853 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1183438005854 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1183438005855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438005856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438005857 active site 1183438005858 phosphorylation site [posttranslational modification] 1183438005859 intermolecular recognition site; other site 1183438005860 dimerization interface [polypeptide binding]; other site 1183438005861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438005862 DNA binding site [nucleotide binding] 1183438005863 Hpt domain; Region: Hpt; pfam01627 1183438005864 putative binding surface; other site 1183438005865 active site 1183438005866 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438005867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438005868 active site 1183438005869 phosphorylation site [posttranslational modification] 1183438005870 intermolecular recognition site; other site 1183438005871 dimerization interface [polypeptide binding]; other site 1183438005872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438005873 PAS domain; Region: PAS_9; pfam13426 1183438005874 putative active site [active] 1183438005875 heme pocket [chemical binding]; other site 1183438005876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438005877 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438005878 putative active site [active] 1183438005879 heme pocket [chemical binding]; other site 1183438005880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438005881 dimer interface [polypeptide binding]; other site 1183438005882 phosphorylation site [posttranslational modification] 1183438005883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438005884 ATP binding site [chemical binding]; other site 1183438005885 Mg2+ binding site [ion binding]; other site 1183438005886 G-X-G motif; other site 1183438005887 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438005888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438005889 active site 1183438005890 phosphorylation site [posttranslational modification] 1183438005891 intermolecular recognition site; other site 1183438005892 dimerization interface [polypeptide binding]; other site 1183438005893 PAS fold; Region: PAS_4; pfam08448 1183438005894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438005895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438005896 dimer interface [polypeptide binding]; other site 1183438005897 phosphorylation site [posttranslational modification] 1183438005898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438005899 ATP binding site [chemical binding]; other site 1183438005900 Mg2+ binding site [ion binding]; other site 1183438005901 G-X-G motif; other site 1183438005902 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438005903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438005904 active site 1183438005905 phosphorylation site [posttranslational modification] 1183438005906 intermolecular recognition site; other site 1183438005907 dimerization interface [polypeptide binding]; other site 1183438005908 PAS fold; Region: PAS_4; pfam08448 1183438005909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438005910 putative active site [active] 1183438005911 heme pocket [chemical binding]; other site 1183438005912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1183438005913 Histidine kinase; Region: HisKA_2; pfam07568 1183438005914 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1183438005915 ATP binding site [chemical binding]; other site 1183438005916 Mg2+ binding site [ion binding]; other site 1183438005917 G-X-G motif; other site 1183438005918 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438005919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438005920 active site 1183438005921 phosphorylation site [posttranslational modification] 1183438005922 intermolecular recognition site; other site 1183438005923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438005924 dimerization interface [polypeptide binding]; other site 1183438005925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438005926 dimer interface [polypeptide binding]; other site 1183438005927 phosphorylation site [posttranslational modification] 1183438005928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438005929 ATP binding site [chemical binding]; other site 1183438005930 Mg2+ binding site [ion binding]; other site 1183438005931 G-X-G motif; other site 1183438005932 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438005933 Ligand Binding Site [chemical binding]; other site 1183438005934 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438005935 Ligand Binding Site [chemical binding]; other site 1183438005936 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1183438005937 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1183438005938 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1183438005939 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1183438005940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438005941 motif II; other site 1183438005942 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1183438005943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438005944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1183438005945 putative substrate translocation pore; other site 1183438005946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438005947 Transglycosylase; Region: Transgly; pfam00912 1183438005948 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1183438005949 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1183438005950 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438005951 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438005952 structural tetrad; other site 1183438005953 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1183438005954 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1183438005955 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1183438005956 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1183438005957 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 1183438005958 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1183438005959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438005960 active site 1183438005961 Integral membrane protein DUF92; Region: DUF92; pfam01940 1183438005962 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1183438005963 SnoaL-like domain; Region: SnoaL_2; pfam12680 1183438005964 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1183438005965 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1183438005966 urea carboxylase; Region: urea_carbox; TIGR02712 1183438005967 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1183438005968 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1183438005969 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1183438005970 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1183438005971 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1183438005972 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1183438005973 carboxyltransferase (CT) interaction site; other site 1183438005974 biotinylation site [posttranslational modification]; other site 1183438005975 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1183438005976 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1183438005977 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1183438005978 Aluminium resistance protein; Region: Alum_res; pfam06838 1183438005979 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1183438005980 SnoaL-like domain; Region: SnoaL_3; pfam13474 1183438005981 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1183438005982 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1183438005983 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1183438005984 iron-sulfur cluster [ion binding]; other site 1183438005985 [2Fe-2S] cluster binding site [ion binding]; other site 1183438005986 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1183438005987 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1183438005988 putative active site [active] 1183438005989 homotetrameric interface [polypeptide binding]; other site 1183438005990 metal binding site [ion binding]; metal-binding site 1183438005991 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438005992 putative active site [active] 1183438005993 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1183438005994 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1183438005995 HEAT repeats; Region: HEAT_2; pfam13646 1183438005996 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1183438005997 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1183438005998 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1183438005999 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1183438006000 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1183438006001 catalytic loop [active] 1183438006002 iron binding site [ion binding]; other site 1183438006003 YtxH-like protein; Region: YtxH; pfam12732 1183438006004 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 1183438006005 diiron binding motif [ion binding]; other site 1183438006006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438006007 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1183438006008 Coenzyme A binding pocket [chemical binding]; other site 1183438006009 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1183438006010 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1183438006011 active site 1183438006012 HIGH motif; other site 1183438006013 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1183438006014 active site 1183438006015 KMSKS motif; other site 1183438006016 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1183438006017 putative ADP-binding pocket [chemical binding]; other site 1183438006018 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438006019 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1183438006020 Active site serine [active] 1183438006021 CTP synthetase; Validated; Region: pyrG; PRK05380 1183438006022 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1183438006023 Catalytic site [active] 1183438006024 active site 1183438006025 UTP binding site [chemical binding]; other site 1183438006026 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1183438006027 active site 1183438006028 putative oxyanion hole; other site 1183438006029 catalytic triad [active] 1183438006030 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 1183438006031 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1183438006032 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1183438006033 G1 box; other site 1183438006034 putative GEF interaction site [polypeptide binding]; other site 1183438006035 GTP/Mg2+ binding site [chemical binding]; other site 1183438006036 Switch I region; other site 1183438006037 G2 box; other site 1183438006038 G3 box; other site 1183438006039 Switch II region; other site 1183438006040 G4 box; other site 1183438006041 G5 box; other site 1183438006042 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1183438006043 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1183438006044 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1183438006045 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1183438006046 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1183438006047 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1183438006048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438006049 Walker A/P-loop; other site 1183438006050 ATP binding site [chemical binding]; other site 1183438006051 Q-loop/lid; other site 1183438006052 ABC transporter signature motif; other site 1183438006053 Walker B; other site 1183438006054 D-loop; other site 1183438006055 H-loop/switch region; other site 1183438006056 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1183438006057 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1183438006058 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1183438006059 NAD(P) binding site [chemical binding]; other site 1183438006060 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1183438006061 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 1183438006062 YceG-like family; Region: YceG; pfam02618 1183438006063 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1183438006064 dimerization interface [polypeptide binding]; other site 1183438006065 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 1183438006066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438006067 homoserine kinase; Provisional; Region: PRK01212 1183438006068 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1183438006069 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1183438006070 substrate binding pocket [chemical binding]; other site 1183438006071 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1183438006072 membrane-bound complex binding site; other site 1183438006073 hinge residues; other site 1183438006074 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1183438006075 Family description; Region: VCBS; pfam13517 1183438006076 Family description; Region: VCBS; pfam13517 1183438006077 Family description; Region: VCBS; pfam13517 1183438006078 Family description; Region: VCBS; pfam13517 1183438006079 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438006080 putative active site [active] 1183438006081 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438006082 Family description; Region: VCBS; pfam13517 1183438006083 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438006084 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438006085 Family description; Region: VCBS; pfam13517 1183438006086 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438006087 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438006088 Family description; Region: VCBS; pfam13517 1183438006089 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438006090 Family description; Region: VCBS; pfam13517 1183438006091 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438006092 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1183438006093 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1183438006094 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 1183438006095 excinuclease ABC subunit B; Provisional; Region: PRK05298 1183438006096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438006097 ATP binding site [chemical binding]; other site 1183438006098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438006099 nucleotide binding region [chemical binding]; other site 1183438006100 ATP-binding site [chemical binding]; other site 1183438006101 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1183438006102 UvrB/uvrC motif; Region: UVR; pfam02151 1183438006103 ScpA/B protein; Region: ScpA_ScpB; pfam02616 1183438006104 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1183438006105 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1183438006106 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1183438006107 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1183438006108 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1183438006109 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1183438006110 inhibitor-cofactor binding pocket; inhibition site 1183438006111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438006112 catalytic residue [active] 1183438006113 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1183438006114 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1183438006115 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1183438006116 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1183438006117 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1183438006118 Surface antigen; Region: Bac_surface_Ag; pfam01103 1183438006119 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1183438006120 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1183438006121 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1183438006122 trimer interface [polypeptide binding]; other site 1183438006123 active site 1183438006124 UDP-GlcNAc binding site [chemical binding]; other site 1183438006125 lipid binding site [chemical binding]; lipid-binding site 1183438006126 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1183438006127 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1183438006128 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1183438006129 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1183438006130 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1183438006131 active site 1183438006132 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1183438006133 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1183438006134 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1183438006135 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438006136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438006137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438006138 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438006139 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438006140 putative active site [active] 1183438006141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1183438006142 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1183438006143 ATP binding site [chemical binding]; other site 1183438006144 Mg2+ binding site [ion binding]; other site 1183438006145 G-X-G motif; other site 1183438006146 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1183438006147 active site 1183438006148 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1183438006149 Bacterial Ig-like domain; Region: Big_5; pfam13205 1183438006150 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1183438006151 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1183438006152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1183438006153 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1183438006154 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1183438006155 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1183438006156 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1183438006157 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1183438006158 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1183438006159 hypothetical protein; Validated; Region: PRK07413 1183438006160 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1183438006161 homodimer interface [polypeptide binding]; other site 1183438006162 Walker A motif; other site 1183438006163 ATP binding site [chemical binding]; other site 1183438006164 hydroxycobalamin binding site [chemical binding]; other site 1183438006165 Walker B motif; other site 1183438006166 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1183438006167 Walker A motif; other site 1183438006168 homodimer interface [polypeptide binding]; other site 1183438006169 ATP binding site [chemical binding]; other site 1183438006170 hydroxycobalamin binding site [chemical binding]; other site 1183438006171 Walker B motif; other site 1183438006172 aldehyde dehydrogenase family 7 member; Region: PLN02315 1183438006173 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1183438006174 tetrameric interface [polypeptide binding]; other site 1183438006175 NAD binding site [chemical binding]; other site 1183438006176 catalytic residues [active] 1183438006177 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1183438006178 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438006179 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1183438006180 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1183438006181 homodimer interface [polypeptide binding]; other site 1183438006182 active site 1183438006183 TDP-binding site; other site 1183438006184 acceptor substrate-binding pocket; other site 1183438006185 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 1183438006186 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438006187 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438006188 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438006189 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438006190 active site 1183438006191 catalytic tetrad [active] 1183438006192 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1183438006193 GIY-YIG motif/motif A; other site 1183438006194 putative active site [active] 1183438006195 putative metal binding site [ion binding]; other site 1183438006196 WYL domain; Region: WYL; cl14852 1183438006197 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 1183438006198 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1183438006199 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1183438006200 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1183438006201 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1183438006202 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 1183438006203 CRISPR-associated protein; Region: TIGR03986 1183438006204 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1183438006205 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1183438006206 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742 1183438006207 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1183438006208 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1183438006209 Zn binding site [ion binding]; other site 1183438006210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1183438006211 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1183438006212 Probable transposase; Region: OrfB_IS605; pfam01385 1183438006213 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1183438006214 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1183438006215 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1183438006216 adenylosuccinate lyase; Provisional; Region: PRK07380 1183438006217 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1183438006218 tetramer interface [polypeptide binding]; other site 1183438006219 active site 1183438006220 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1183438006221 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1183438006222 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1183438006223 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1183438006224 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1183438006225 dimer interface [polypeptide binding]; other site 1183438006226 ssDNA binding site [nucleotide binding]; other site 1183438006227 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1183438006228 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1183438006229 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1183438006230 dimer interface [polypeptide binding]; other site 1183438006231 ssDNA binding site [nucleotide binding]; other site 1183438006232 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1183438006233 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1183438006234 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1183438006235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1183438006236 putative phosphoketolase; Provisional; Region: PRK05261 1183438006237 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1183438006238 TPP-binding site; other site 1183438006239 XFP C-terminal domain; Region: XFP_C; pfam09363 1183438006240 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 1183438006241 UbiA prenyltransferase family; Region: UbiA; pfam01040 1183438006242 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 1183438006243 Putative restriction endonuclease; Region: Uma2; pfam05685 1183438006244 putative active site [active] 1183438006245 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438006246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438006247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438006248 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438006249 TPR repeat; Region: TPR_11; pfam13414 1183438006250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438006251 TPR motif; other site 1183438006252 binding surface 1183438006253 TPR repeat; Region: TPR_11; pfam13414 1183438006254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438006255 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438006256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438006257 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1183438006258 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1183438006259 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1183438006260 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1183438006261 Ligand binding site; other site 1183438006262 Putative Catalytic site; other site 1183438006263 DXD motif; other site 1183438006264 Predicted membrane protein [Function unknown]; Region: COG2246 1183438006265 GtrA-like protein; Region: GtrA; pfam04138 1183438006266 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1183438006267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438006268 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438006269 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1183438006270 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1183438006271 active site 1183438006272 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1183438006273 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438006274 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438006275 active site 1183438006276 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1183438006277 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1183438006278 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1183438006279 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1183438006280 Walker A/P-loop; other site 1183438006281 ATP binding site [chemical binding]; other site 1183438006282 Q-loop/lid; other site 1183438006283 ABC transporter signature motif; other site 1183438006284 Walker B; other site 1183438006285 D-loop; other site 1183438006286 H-loop/switch region; other site 1183438006287 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1183438006288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438006289 active site 1183438006290 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1183438006291 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438006292 active site 1183438006293 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1183438006294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438006295 active site 1183438006296 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438006297 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438006298 active site 1183438006299 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1183438006300 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1183438006301 trimer interface [polypeptide binding]; other site 1183438006302 active site 1183438006303 substrate binding site [chemical binding]; other site 1183438006304 CoA binding site [chemical binding]; other site 1183438006305 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1183438006306 active site 1183438006307 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1183438006308 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1183438006309 Exostosin family; Region: Exostosin; pfam03016 1183438006310 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1183438006311 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1183438006312 active site 1183438006313 Substrate binding site; other site 1183438006314 Mg++ binding site; other site 1183438006315 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438006316 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1183438006317 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1183438006318 SLBB domain; Region: SLBB; pfam10531 1183438006319 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1183438006320 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1183438006321 AAA domain; Region: AAA_31; pfam13614 1183438006322 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1183438006323 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1183438006324 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1183438006325 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1183438006326 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1183438006327 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1183438006328 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1183438006329 Walker A/P-loop; other site 1183438006330 ATP binding site [chemical binding]; other site 1183438006331 Q-loop/lid; other site 1183438006332 ABC transporter signature motif; other site 1183438006333 Walker B; other site 1183438006334 D-loop; other site 1183438006335 H-loop/switch region; other site 1183438006336 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1183438006337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1183438006338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438006339 Walker A/P-loop; other site 1183438006340 ATP binding site [chemical binding]; other site 1183438006341 Q-loop/lid; other site 1183438006342 ABC transporter signature motif; other site 1183438006343 Walker B; other site 1183438006344 D-loop; other site 1183438006345 H-loop/switch region; other site 1183438006346 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1183438006347 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438006348 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438006349 active site 1183438006350 ATP binding site [chemical binding]; other site 1183438006351 substrate binding site [chemical binding]; other site 1183438006352 activation loop (A-loop); other site 1183438006353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438006354 binding surface 1183438006355 TPR motif; other site 1183438006356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438006357 binding surface 1183438006358 TPR repeat; Region: TPR_11; pfam13414 1183438006359 TPR motif; other site 1183438006360 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1183438006361 active site lid residues [active] 1183438006362 substrate binding pocket [chemical binding]; other site 1183438006363 catalytic residues [active] 1183438006364 substrate-Mg2+ binding site; other site 1183438006365 aspartate-rich region 1; other site 1183438006366 aspartate-rich region 2; other site 1183438006367 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1183438006368 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1183438006369 Active site cavity [active] 1183438006370 catalytic acid [active] 1183438006371 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1183438006372 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1183438006373 active site 1183438006374 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 1183438006375 YceI-like domain; Region: YceI; pfam04264 1183438006376 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1183438006377 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1183438006378 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1183438006379 putative active site [active] 1183438006380 putative substrate binding site [chemical binding]; other site 1183438006381 putative cosubstrate binding site; other site 1183438006382 catalytic site [active] 1183438006383 cyanophycin synthetase; Provisional; Region: PRK14016 1183438006384 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1183438006385 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1183438006386 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1183438006387 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1183438006388 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1183438006389 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1183438006390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438006391 active site 1183438006392 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1183438006393 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1183438006394 TM-ABC transporter signature motif; other site 1183438006395 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1183438006396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438006397 FeS/SAM binding site; other site 1183438006398 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1183438006399 Caspase domain; Region: Peptidase_C14; pfam00656 1183438006400 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438006401 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438006402 structural tetrad; other site 1183438006403 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438006404 structural tetrad; other site 1183438006405 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438006406 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1183438006407 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1183438006408 putative active site [active] 1183438006409 catalytic site [active] 1183438006410 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 1183438006411 putative active site [active] 1183438006412 catalytic site [active] 1183438006413 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1183438006414 putative catalytic site [active] 1183438006415 putative metal binding site [ion binding]; other site 1183438006416 putative phosphate binding site [ion binding]; other site 1183438006417 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1183438006418 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1183438006419 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1183438006420 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1183438006421 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1183438006422 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1183438006423 Predicted ATPase [General function prediction only]; Region: COG4637 1183438006424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438006425 Walker A/P-loop; other site 1183438006426 ATP binding site [chemical binding]; other site 1183438006427 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1183438006428 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 1183438006429 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1183438006430 active site 1183438006431 catalytic residues [active] 1183438006432 metal binding site [ion binding]; metal-binding site 1183438006433 homodimer binding site [polypeptide binding]; other site 1183438006434 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1183438006435 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438006436 catalytic residues [active] 1183438006437 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1183438006438 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1183438006439 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1183438006440 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 1183438006441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438006442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438006443 active site 1183438006444 catalytic tetrad [active] 1183438006445 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1183438006446 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1183438006447 minor groove reading motif; other site 1183438006448 helix-hairpin-helix signature motif; other site 1183438006449 substrate binding pocket [chemical binding]; other site 1183438006450 active site 1183438006451 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1183438006452 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1183438006453 DNA binding and oxoG recognition site [nucleotide binding] 1183438006454 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1183438006455 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1183438006456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438006457 putative ADP-binding pocket [chemical binding]; other site 1183438006458 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 1183438006459 active site 1183438006460 catalytic residues [active] 1183438006461 OB-fold nucleic acid binding domain; Region: tRNA_anti; pfam01336 1183438006462 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1183438006463 dimer interface [polypeptide binding]; other site 1183438006464 [2Fe-2S] cluster binding site [ion binding]; other site 1183438006465 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1183438006466 Ferritin-like domain; Region: Ferritin; pfam00210 1183438006467 dimerization interface [polypeptide binding]; other site 1183438006468 DPS ferroxidase diiron center [ion binding]; other site 1183438006469 ion pore; other site 1183438006470 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1183438006471 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 1183438006472 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1183438006473 gamma subunit interface [polypeptide binding]; other site 1183438006474 epsilon subunit interface [polypeptide binding]; other site 1183438006475 LBP interface [polypeptide binding]; other site 1183438006476 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1183438006477 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1183438006478 E3 interaction surface; other site 1183438006479 lipoyl attachment site [posttranslational modification]; other site 1183438006480 e3 binding domain; Region: E3_binding; pfam02817 1183438006481 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1183438006482 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1183438006483 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1183438006484 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1183438006485 alpha subunit interaction interface [polypeptide binding]; other site 1183438006486 Walker A motif; other site 1183438006487 ATP binding site [chemical binding]; other site 1183438006488 Walker B motif; other site 1183438006489 inhibitor binding site; inhibition site 1183438006490 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1183438006491 Cation efflux family; Region: Cation_efflux; cl00316 1183438006492 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1183438006493 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1183438006494 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1183438006495 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1183438006496 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438006497 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1183438006498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438006499 DNA binding residues [nucleotide binding] 1183438006500 Predicted transcriptional regulator [Transcription]; Region: COG2378 1183438006501 HTH domain; Region: HTH_11; pfam08279 1183438006502 WYL domain; Region: WYL; pfam13280 1183438006503 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438006504 putative active site [active] 1183438006505 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438006506 putative active site [active] 1183438006507 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 1183438006508 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1183438006509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1183438006510 Integrase core domain; Region: rve; pfam00665 1183438006511 Integrase core domain; Region: rve_3; pfam13683 1183438006512 Transposase; Region: HTH_Tnp_1; pfam01527 1183438006513 CRISPR-associated helicase Cas3; frameshifted 1183438006514 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1183438006515 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1183438006516 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1183438006517 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1183438006518 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1183438006519 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1183438006520 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1183438006521 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1183438006522 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1183438006523 IMP binding site; other site 1183438006524 dimer interface [polypeptide binding]; other site 1183438006525 partial ornithine binding site; other site 1183438006526 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1183438006527 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1183438006528 quinolinate synthetase; Provisional; Region: PRK09375 1183438006529 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1183438006530 Pectate lyase; Region: Pec_lyase_C; cl01593 1183438006531 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1183438006532 Sporulation related domain; Region: SPOR; pfam05036 1183438006533 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 1183438006534 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1183438006535 thiamine phosphate binding site [chemical binding]; other site 1183438006536 active site 1183438006537 pyrophosphate binding site [ion binding]; other site 1183438006538 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1183438006539 thiS-thiF/thiG interaction site; other site 1183438006540 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1183438006541 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1183438006542 Ligand Binding Site [chemical binding]; other site 1183438006543 Class I aldolases; Region: Aldolase_Class_I; cl17187 1183438006544 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438006545 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1183438006546 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1183438006547 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1183438006548 active site 1183438006549 metal binding site [ion binding]; metal-binding site 1183438006550 Conserved TM helix; Region: TM_helix; pfam05552 1183438006551 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1183438006552 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1183438006553 GatB domain; Region: GatB_Yqey; smart00845 1183438006554 plastocyanin; Provisional; Region: PRK02710 1183438006555 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1183438006556 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1183438006557 putative nucleotide binding site [chemical binding]; other site 1183438006558 uridine monophosphate binding site [chemical binding]; other site 1183438006559 homohexameric interface [polypeptide binding]; other site 1183438006560 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1183438006561 cytochrome c-550; Provisional; Region: psbV; cl17239 1183438006562 cytochrome c-550; Provisional; Region: psbV; cl17239 1183438006563 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1183438006564 hydrolase, alpha/beta fold family protein; Region: PLN02824 1183438006565 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1183438006566 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1183438006567 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438006568 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438006569 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1183438006570 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1183438006571 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1183438006572 Walker A/P-loop; other site 1183438006573 ATP binding site [chemical binding]; other site 1183438006574 Q-loop/lid; other site 1183438006575 ABC transporter signature motif; other site 1183438006576 Walker B; other site 1183438006577 D-loop; other site 1183438006578 H-loop/switch region; other site 1183438006579 Photosystem II protein; Region: PSII; cl08223 1183438006580 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 1183438006581 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1183438006582 pheophytin binding site; other site 1183438006583 chlorophyll binding site; other site 1183438006584 quinone binding site; other site 1183438006585 Fe binding site [ion binding]; other site 1183438006586 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1183438006587 protein I interface; other site 1183438006588 D2 interface; other site 1183438006589 protein T interface; other site 1183438006590 chlorophyll binding site; other site 1183438006591 beta carotene binding site; other site 1183438006592 pheophytin binding site; other site 1183438006593 manganese-stabilizing polypeptide interface; other site 1183438006594 CP43 interface; other site 1183438006595 protein L interface; other site 1183438006596 oxygen evolving complex binding site; other site 1183438006597 bromide binding site; other site 1183438006598 quinone binding site; other site 1183438006599 Fe binding site [ion binding]; other site 1183438006600 core light harvesting interface; other site 1183438006601 cytochrome b559 alpha subunit interface; other site 1183438006602 cytochrome c-550 interface; other site 1183438006603 protein J interface; other site 1183438006604 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1183438006605 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1183438006606 homodimer interface [polypeptide binding]; other site 1183438006607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438006608 catalytic residue [active] 1183438006609 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1183438006610 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1183438006611 FAD binding domain; Region: FAD_binding_4; pfam01565 1183438006612 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1183438006613 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1183438006614 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1183438006615 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1183438006616 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1183438006617 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1183438006618 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1183438006619 substrate binding site [chemical binding]; other site 1183438006620 dimer interface [polypeptide binding]; other site 1183438006621 ATP binding site [chemical binding]; other site 1183438006622 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1183438006623 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1183438006624 dimerization interface [polypeptide binding]; other site 1183438006625 putative ATP binding site [chemical binding]; other site 1183438006626 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1183438006627 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1183438006628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438006629 catalytic residue [active] 1183438006630 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1183438006631 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1183438006632 elongation factor P; Validated; Region: PRK00529 1183438006633 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1183438006634 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1183438006635 RNA binding site [nucleotide binding]; other site 1183438006636 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1183438006637 RNA binding site [nucleotide binding]; other site 1183438006638 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1183438006639 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1183438006640 carboxyltransferase (CT) interaction site; other site 1183438006641 biotinylation site [posttranslational modification]; other site 1183438006642 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1183438006643 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1183438006644 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1183438006645 trimer interface [polypeptide binding]; other site 1183438006646 active site 1183438006647 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1183438006648 catalytic site [active] 1183438006649 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1183438006650 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1183438006651 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1183438006652 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1183438006653 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1183438006654 TPP-binding site; other site 1183438006655 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1183438006656 PYR/PP interface [polypeptide binding]; other site 1183438006657 dimer interface [polypeptide binding]; other site 1183438006658 TPP binding site [chemical binding]; other site 1183438006659 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1183438006660 Ion transport protein; Region: Ion_trans; pfam00520 1183438006661 Ion channel; Region: Ion_trans_2; pfam07885 1183438006662 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1183438006663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438006664 NAD(P) binding site [chemical binding]; other site 1183438006665 active site 1183438006666 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1183438006667 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1183438006668 ligand binding site [chemical binding]; other site 1183438006669 flexible hinge region; other site 1183438006670 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1183438006671 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1183438006672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438006673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438006674 DNA binding residues [nucleotide binding] 1183438006675 putative anti-sigmaE protein; Provisional; Region: PRK13920 1183438006676 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1183438006677 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1183438006678 active sites [active] 1183438006679 tetramer interface [polypeptide binding]; other site 1183438006680 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1183438006681 peptidase domain interface [polypeptide binding]; other site 1183438006682 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1183438006683 active site 1183438006684 catalytic triad [active] 1183438006685 calcium binding site [ion binding]; other site 1183438006686 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 1183438006687 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1183438006688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438006689 homodimer interface [polypeptide binding]; other site 1183438006690 catalytic residue [active] 1183438006691 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1183438006692 histidinol dehydrogenase; Region: hisD; TIGR00069 1183438006693 NAD binding site [chemical binding]; other site 1183438006694 dimerization interface [polypeptide binding]; other site 1183438006695 product binding site; other site 1183438006696 substrate binding site [chemical binding]; other site 1183438006697 zinc binding site [ion binding]; other site 1183438006698 catalytic residues [active] 1183438006699 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1183438006700 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1183438006701 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1183438006702 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438006703 ATP binding site [chemical binding]; other site 1183438006704 putative Mg++ binding site [ion binding]; other site 1183438006705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438006706 nucleotide binding region [chemical binding]; other site 1183438006707 ATP-binding site [chemical binding]; other site 1183438006708 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1183438006709 HlyD family secretion protein; Region: HlyD_2; pfam12700 1183438006710 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438006711 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438006712 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1183438006713 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1183438006714 Walker A/P-loop; other site 1183438006715 ATP binding site [chemical binding]; other site 1183438006716 Q-loop/lid; other site 1183438006717 ABC transporter signature motif; other site 1183438006718 Walker B; other site 1183438006719 D-loop; other site 1183438006720 H-loop/switch region; other site 1183438006721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438006722 active site 1183438006723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438006724 phosphorylation site [posttranslational modification] 1183438006725 intermolecular recognition site; other site 1183438006726 dimerization interface [polypeptide binding]; other site 1183438006727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438006728 dimer interface [polypeptide binding]; other site 1183438006729 phosphorylation site [posttranslational modification] 1183438006730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438006731 ATP binding site [chemical binding]; other site 1183438006732 Mg2+ binding site [ion binding]; other site 1183438006733 G-X-G motif; other site 1183438006734 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1183438006735 catalytic site [active] 1183438006736 putative active site [active] 1183438006737 putative substrate binding site [chemical binding]; other site 1183438006738 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1183438006739 ABC1 family; Region: ABC1; pfam03109 1183438006740 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1183438006741 active site 1183438006742 ATP binding site [chemical binding]; other site 1183438006743 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1183438006744 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1183438006745 hinge; other site 1183438006746 active site 1183438006747 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438006748 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438006749 active site 1183438006750 catalytic tetrad [active] 1183438006751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438006752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438006753 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438006754 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438006755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438006756 S-adenosylmethionine binding site [chemical binding]; other site 1183438006757 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1183438006758 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1183438006759 putative substrate binding site [chemical binding]; other site 1183438006760 putative ATP binding site [chemical binding]; other site 1183438006761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1183438006762 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1183438006763 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1183438006764 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1183438006765 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1183438006766 putative dimer interface [polypeptide binding]; other site 1183438006767 N-terminal domain interface [polypeptide binding]; other site 1183438006768 putative substrate binding pocket (H-site) [chemical binding]; other site 1183438006769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438006770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438006771 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1183438006772 active site 1183438006773 DNA binding site [nucleotide binding] 1183438006774 Int/Topo IB signature motif; other site 1183438006775 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1183438006776 Di-iron ligands [ion binding]; other site 1183438006777 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438006778 putative active site [active] 1183438006779 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1183438006780 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1183438006781 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1183438006782 catalytic loop [active] 1183438006783 iron binding site [ion binding]; other site 1183438006784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438006785 binding surface 1183438006786 TPR motif; other site 1183438006787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438006788 TPR motif; other site 1183438006789 TPR repeat; Region: TPR_11; pfam13414 1183438006790 binding surface 1183438006791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438006792 binding surface 1183438006793 TPR motif; other site 1183438006794 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1183438006795 cytosine deaminase; Validated; Region: PRK07572 1183438006796 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1183438006797 active site 1183438006798 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1183438006799 Ferritin-like domain; Region: Ferritin; pfam00210 1183438006800 dimanganese center [ion binding]; other site 1183438006801 Phytase; Region: Phytase; cl17685 1183438006802 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1183438006803 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1183438006804 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1183438006805 Walker A/P-loop; other site 1183438006806 ATP binding site [chemical binding]; other site 1183438006807 Q-loop/lid; other site 1183438006808 ABC transporter signature motif; other site 1183438006809 Walker B; other site 1183438006810 D-loop; other site 1183438006811 H-loop/switch region; other site 1183438006812 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1183438006813 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1183438006814 NAD binding site [chemical binding]; other site 1183438006815 catalytic Zn binding site [ion binding]; other site 1183438006816 structural Zn binding site [ion binding]; other site 1183438006817 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1183438006818 Predicted integral membrane protein [Function unknown]; Region: COG5637 1183438006819 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1183438006820 putative hydrophobic ligand binding site [chemical binding]; other site 1183438006821 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1183438006822 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1183438006823 putative active site; other site 1183438006824 catalytic triad [active] 1183438006825 putative dimer interface [polypeptide binding]; other site 1183438006826 AAA ATPase domain; Region: AAA_15; pfam13175 1183438006827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438006828 Walker A/P-loop; other site 1183438006829 ATP binding site [chemical binding]; other site 1183438006830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438006831 ABC transporter signature motif; other site 1183438006832 Walker B; other site 1183438006833 D-loop; other site 1183438006834 H-loop/switch region; other site 1183438006835 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1183438006836 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1183438006837 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1183438006838 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1183438006839 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1183438006840 nucleotide binding site [chemical binding]; other site 1183438006841 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1183438006842 SBD interface [polypeptide binding]; other site 1183438006843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438006844 Coenzyme A binding pocket [chemical binding]; other site 1183438006845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438006846 Coenzyme A binding pocket [chemical binding]; other site 1183438006847 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 1183438006848 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1183438006849 C-terminal domain interface [polypeptide binding]; other site 1183438006850 active site 1183438006851 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1183438006852 active site 1183438006853 N-terminal domain interface [polypeptide binding]; other site 1183438006854 PRC-barrel domain; Region: PRC; pfam05239 1183438006855 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438006857 S-adenosylmethionine binding site [chemical binding]; other site 1183438006858 hypothetical protein; Provisional; Region: PRK06834 1183438006859 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1183438006860 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1183438006861 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1183438006862 dimer interface [polypeptide binding]; other site 1183438006863 [2Fe-2S] cluster binding site [ion binding]; other site 1183438006864 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1183438006865 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1183438006866 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1183438006867 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1183438006868 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1183438006869 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1183438006870 C-terminal peptidase (prc); Region: prc; TIGR00225 1183438006871 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438006872 protein binding site [polypeptide binding]; other site 1183438006873 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1183438006874 Catalytic dyad [active] 1183438006875 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1183438006876 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1183438006877 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1183438006878 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438006879 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1183438006880 FOG: CBS domain [General function prediction only]; Region: COG0517 1183438006881 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 1183438006882 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1183438006883 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1183438006884 active site 1183438006885 NTP binding site [chemical binding]; other site 1183438006886 metal binding triad [ion binding]; metal-binding site 1183438006887 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1183438006888 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438006889 Ligand Binding Site [chemical binding]; other site 1183438006890 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1183438006891 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1183438006892 putative active site [active] 1183438006893 metal binding site [ion binding]; metal-binding site 1183438006894 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1183438006895 active site 1183438006896 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1183438006897 Ycf39; Provisional; Region: ycf39; CHL00194 1183438006898 NAD(P) binding site [chemical binding]; other site 1183438006899 putative active site [active] 1183438006900 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1183438006901 DNA binding site [nucleotide binding] 1183438006902 active site 1183438006903 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1183438006904 AIR carboxylase; Region: AIRC; smart01001 1183438006905 threonine synthase; Reviewed; Region: PRK06721 1183438006906 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1183438006907 homodimer interface [polypeptide binding]; other site 1183438006908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438006909 catalytic residue [active] 1183438006910 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1183438006911 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1183438006912 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1183438006913 trimer interface [polypeptide binding]; other site 1183438006914 active site 1183438006915 rod shape-determining protein MreB; Provisional; Region: PRK13927 1183438006916 MreB and similar proteins; Region: MreB_like; cd10225 1183438006917 nucleotide binding site [chemical binding]; other site 1183438006918 Mg binding site [ion binding]; other site 1183438006919 putative protofilament interaction site [polypeptide binding]; other site 1183438006920 RodZ interaction site [polypeptide binding]; other site 1183438006921 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1183438006922 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438006923 Ion channel; Region: Ion_trans_2; pfam07885 1183438006924 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1183438006925 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1183438006926 active site 1183438006927 metal binding site [ion binding]; metal-binding site 1183438006928 dihydroorotase; Provisional; Region: PRK07369 1183438006929 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1183438006930 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1183438006931 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1183438006932 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438006933 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438006934 active site 1183438006935 catalytic tetrad [active] 1183438006936 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1183438006937 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1183438006938 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 1183438006939 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1183438006940 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1183438006941 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1183438006942 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1183438006943 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1183438006944 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1183438006945 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1183438006946 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1183438006947 NAD(P) binding site [chemical binding]; other site 1183438006948 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 1183438006949 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1183438006950 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1183438006951 ABC1 family; Region: ABC1; cl17513 1183438006952 MarC family integral membrane protein; Region: MarC; pfam01914 1183438006953 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1183438006954 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1183438006955 Walker A motif; other site 1183438006956 ATP binding site [chemical binding]; other site 1183438006957 Walker B motif; other site 1183438006958 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1183438006959 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438006960 putative active site [active] 1183438006961 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1183438006962 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1183438006963 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1183438006964 Presynaptic Site I dimer interface [polypeptide binding]; other site 1183438006965 catalytic residues [active] 1183438006966 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1183438006967 Synaptic Flat tetramer interface [polypeptide binding]; other site 1183438006968 Synaptic Site I dimer interface [polypeptide binding]; other site 1183438006969 DNA binding site [nucleotide binding] 1183438006970 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1183438006971 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1183438006972 catalytic nucleophile [active] 1183438006973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438006974 NAD(P) binding site [chemical binding]; other site 1183438006975 active site 1183438006976 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1183438006977 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1183438006978 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1183438006979 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1183438006980 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1183438006981 23S rRNA interface [nucleotide binding]; other site 1183438006982 L21e interface [polypeptide binding]; other site 1183438006983 5S rRNA interface [nucleotide binding]; other site 1183438006984 L27 interface [polypeptide binding]; other site 1183438006985 L5 interface [polypeptide binding]; other site 1183438006986 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1183438006987 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1183438006988 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1183438006989 ribosomal protein S8; Region: rps8; CHL00042 1183438006990 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1183438006991 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1183438006992 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1183438006993 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1183438006994 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1183438006995 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1183438006996 RNA binding site [nucleotide binding]; other site 1183438006997 ribosomal protein L14; Region: rpl14; CHL00057 1183438006998 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1183438006999 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1183438007000 putative translocon interaction site; other site 1183438007001 23S rRNA interface [nucleotide binding]; other site 1183438007002 signal recognition particle (SRP54) interaction site; other site 1183438007003 L23 interface [polypeptide binding]; other site 1183438007004 trigger factor interaction site; other site 1183438007005 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1183438007006 23S rRNA interface [nucleotide binding]; other site 1183438007007 5S rRNA interface [nucleotide binding]; other site 1183438007008 putative antibiotic binding site [chemical binding]; other site 1183438007009 L25 interface [polypeptide binding]; other site 1183438007010 L27 interface [polypeptide binding]; other site 1183438007011 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1183438007012 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1183438007013 G-X-X-G motif; other site 1183438007014 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1183438007015 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1183438007016 putative translocon binding site; other site 1183438007017 protein-rRNA interface [nucleotide binding]; other site 1183438007018 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1183438007019 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1183438007020 putative catalytic cysteine [active] 1183438007021 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1183438007022 S17 interaction site [polypeptide binding]; other site 1183438007023 S8 interaction site; other site 1183438007024 16S rRNA interaction site [nucleotide binding]; other site 1183438007025 streptomycin interaction site [chemical binding]; other site 1183438007026 23S rRNA interaction site [nucleotide binding]; other site 1183438007027 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1183438007028 30S ribosomal protein S7; Validated; Region: PRK05302 1183438007029 elongation factor G; Reviewed; Region: PRK00007 1183438007030 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1183438007031 G1 box; other site 1183438007032 putative GEF interaction site [polypeptide binding]; other site 1183438007033 GTP/Mg2+ binding site [chemical binding]; other site 1183438007034 Switch I region; other site 1183438007035 G2 box; other site 1183438007036 G3 box; other site 1183438007037 Switch II region; other site 1183438007038 G4 box; other site 1183438007039 G5 box; other site 1183438007040 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1183438007041 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1183438007042 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1183438007043 elongation factor Tu; Region: tufA; CHL00071 1183438007044 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1183438007045 G1 box; other site 1183438007046 GEF interaction site [polypeptide binding]; other site 1183438007047 GTP/Mg2+ binding site [chemical binding]; other site 1183438007048 Switch I region; other site 1183438007049 G2 box; other site 1183438007050 G3 box; other site 1183438007051 Switch II region; other site 1183438007052 G4 box; other site 1183438007053 G5 box; other site 1183438007054 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1183438007055 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1183438007056 Antibiotic Binding Site [chemical binding]; other site 1183438007057 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1183438007058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1183438007059 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1183438007060 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1183438007061 tellurium resistance terB-like protein; Region: terB_like; cd07177 1183438007062 metal binding site [ion binding]; metal-binding site 1183438007063 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1183438007064 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438007065 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438007066 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 1183438007067 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1183438007068 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1183438007069 active site 1183438007070 dimerization interface [polypeptide binding]; other site 1183438007071 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1183438007072 CGNR zinc finger; Region: zf-CGNR; pfam11706 1183438007073 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1183438007074 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1183438007075 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1183438007076 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1183438007077 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1183438007078 hinge region; other site 1183438007079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438007080 TPR repeat; Region: TPR_11; pfam13414 1183438007081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007082 binding surface 1183438007083 TPR motif; other site 1183438007084 TPR repeat; Region: TPR_11; pfam13414 1183438007085 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 1183438007086 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1183438007087 UbiA prenyltransferase family; Region: UbiA; pfam01040 1183438007088 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1183438007089 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1183438007090 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1183438007091 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1183438007092 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1183438007093 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1183438007094 Predicted membrane protein [Function unknown]; Region: COG4244 1183438007095 Predicted membrane protein [Function unknown]; Region: COG4244 1183438007096 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1183438007097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438007098 dimerization interface [polypeptide binding]; other site 1183438007099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438007100 dimerization interface [polypeptide binding]; other site 1183438007101 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1183438007102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438007103 dimerization interface [polypeptide binding]; other site 1183438007104 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438007105 dimerization interface [polypeptide binding]; other site 1183438007106 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1183438007107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438007108 dimerization interface [polypeptide binding]; other site 1183438007109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438007110 dimerization interface [polypeptide binding]; other site 1183438007111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438007112 dimerization interface [polypeptide binding]; other site 1183438007113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438007114 dimerization interface [polypeptide binding]; other site 1183438007115 GAF domain; Region: GAF_2; pfam13185 1183438007116 GAF domain; Region: GAF; pfam01590 1183438007117 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1183438007118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438007119 ATP binding site [chemical binding]; other site 1183438007120 Mg2+ binding site [ion binding]; other site 1183438007121 G-X-G motif; other site 1183438007122 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438007123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438007124 active site 1183438007125 phosphorylation site [posttranslational modification] 1183438007126 intermolecular recognition site; other site 1183438007127 dimerization interface [polypeptide binding]; other site 1183438007128 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438007129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438007130 active site 1183438007131 phosphorylation site [posttranslational modification] 1183438007132 intermolecular recognition site; other site 1183438007133 dimerization interface [polypeptide binding]; other site 1183438007134 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438007135 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438007136 putative active site [active] 1183438007137 heme pocket [chemical binding]; other site 1183438007138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438007139 dimer interface [polypeptide binding]; other site 1183438007140 phosphorylation site [posttranslational modification] 1183438007141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438007142 ATP binding site [chemical binding]; other site 1183438007143 Mg2+ binding site [ion binding]; other site 1183438007144 G-X-G motif; other site 1183438007145 Phage protein D [General function prediction only]; Region: COG3500 1183438007146 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1183438007147 ribonuclease E; Reviewed; Region: rne; PRK10811 1183438007148 conserved hypothetical phage tail region protein; Region: TIGR02241 1183438007149 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1183438007150 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1183438007151 phosphopeptide binding site; other site 1183438007152 Protein kinase domain; Region: Pkinase; pfam00069 1183438007153 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1183438007154 active site 1183438007155 ATP binding site [chemical binding]; other site 1183438007156 substrate binding site [chemical binding]; other site 1183438007157 activation loop (A-loop); other site 1183438007158 PBP superfamily domain; Region: PBP_like_2; cl17296 1183438007159 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1183438007160 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1183438007161 phosphopeptide binding site; other site 1183438007162 NHL repeat; Region: NHL; pfam01436 1183438007163 NHL repeat; Region: NHL; pfam01436 1183438007164 peptide synthase; Provisional; Region: PRK12316 1183438007165 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1183438007166 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1183438007167 active site 1183438007168 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1183438007169 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1183438007170 putative dimer interface [polypeptide binding]; other site 1183438007171 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1183438007172 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1183438007173 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1183438007174 homotrimer interaction site [polypeptide binding]; other site 1183438007175 active site 1183438007176 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1183438007177 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1183438007178 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1183438007179 active site 1183438007180 substrate binding site [chemical binding]; other site 1183438007181 cosubstrate binding site; other site 1183438007182 catalytic site [active] 1183438007183 Thf1-like protein; Reviewed; Region: PRK13266 1183438007184 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 1183438007185 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 1183438007186 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1183438007187 putative active site pocket [active] 1183438007188 dimerization interface [polypeptide binding]; other site 1183438007189 putative catalytic residue [active] 1183438007190 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1183438007191 phosphatidate cytidylyltransferase; Region: PLN02953 1183438007192 RDD family; Region: RDD; pfam06271 1183438007193 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 1183438007194 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1183438007195 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1183438007196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438007197 FeS/SAM binding site; other site 1183438007198 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1183438007199 SecY translocase; Region: SecY; pfam00344 1183438007200 adenylate kinase; Reviewed; Region: adk; PRK00279 1183438007201 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1183438007202 AMP-binding site [chemical binding]; other site 1183438007203 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1183438007204 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1183438007205 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1183438007206 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1183438007207 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1183438007208 P loop; other site 1183438007209 Nucleotide binding site [chemical binding]; other site 1183438007210 DTAP/Switch II; other site 1183438007211 Switch I; other site 1183438007212 TonB family protein; frameshifted 1183438007213 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1183438007214 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1183438007215 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1183438007216 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1183438007217 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1183438007218 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1183438007219 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1183438007220 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1183438007221 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1183438007222 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1183438007223 HSP70 interaction site [polypeptide binding]; other site 1183438007224 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 1183438007225 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1183438007226 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1183438007227 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1183438007228 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1183438007229 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1183438007230 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1183438007231 Predicted membrane protein [Function unknown]; Region: COG4325 1183438007232 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1183438007233 TPR repeat; Region: TPR_11; pfam13414 1183438007234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007235 binding surface 1183438007236 TPR motif; other site 1183438007237 TPR repeat; Region: TPR_11; pfam13414 1183438007238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007239 binding surface 1183438007240 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1183438007241 TPR motif; other site 1183438007242 TPR repeat; Region: TPR_11; pfam13414 1183438007243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007244 binding surface 1183438007245 TPR motif; other site 1183438007246 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1183438007247 RNA recognition motif; Region: RRM; smart00360 1183438007248 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1183438007249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438007250 active site 1183438007251 phosphorylation site [posttranslational modification] 1183438007252 intermolecular recognition site; other site 1183438007253 dimerization interface [polypeptide binding]; other site 1183438007254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438007255 DNA binding site [nucleotide binding] 1183438007256 TrkA-N domain; Region: TrkA_N; pfam02254 1183438007257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438007258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438007259 dimer interface [polypeptide binding]; other site 1183438007260 phosphorylation site [posttranslational modification] 1183438007261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438007262 ATP binding site [chemical binding]; other site 1183438007263 Mg2+ binding site [ion binding]; other site 1183438007264 G-X-G motif; other site 1183438007265 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438007266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438007267 active site 1183438007268 phosphorylation site [posttranslational modification] 1183438007269 intermolecular recognition site; other site 1183438007270 dimerization interface [polypeptide binding]; other site 1183438007271 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438007272 DNA binding residues [nucleotide binding] 1183438007273 dimerization interface [polypeptide binding]; other site 1183438007274 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1183438007275 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1183438007276 Ligand Binding Site [chemical binding]; other site 1183438007277 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1183438007278 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1183438007279 Ligand Binding Site [chemical binding]; other site 1183438007280 integrase core domain protein; fragment 1183438007281 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1183438007282 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1183438007283 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1183438007284 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1183438007285 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1183438007286 binuclear metal center [ion binding]; other site 1183438007287 Rubrerythrin [Energy production and conversion]; Region: COG1592 1183438007288 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1183438007289 pheophytin binding site; other site 1183438007290 chlorophyll binding site; other site 1183438007291 quinone binding site; other site 1183438007292 Fe binding site [ion binding]; other site 1183438007293 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1183438007294 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1183438007295 putative active site [active] 1183438007296 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1183438007297 C-terminal peptidase (prc); Region: prc; TIGR00225 1183438007298 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438007299 protein binding site [polypeptide binding]; other site 1183438007300 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1183438007301 Catalytic dyad [active] 1183438007302 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1183438007303 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1183438007304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438007305 active site 1183438007306 phosphorylation site [posttranslational modification] 1183438007307 intermolecular recognition site; other site 1183438007308 dimerization interface [polypeptide binding]; other site 1183438007309 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1183438007310 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1183438007311 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438007312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438007313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438007314 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438007315 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1183438007316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438007317 dimer interface [polypeptide binding]; other site 1183438007318 conserved gate region; other site 1183438007319 putative PBP binding loops; other site 1183438007320 ABC-ATPase subunit interface; other site 1183438007321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1183438007322 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1183438007323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438007324 Walker A/P-loop; other site 1183438007325 ATP binding site [chemical binding]; other site 1183438007326 Q-loop/lid; other site 1183438007327 ABC transporter signature motif; other site 1183438007328 Walker B; other site 1183438007329 D-loop; other site 1183438007330 H-loop/switch region; other site 1183438007331 TOBE domain; Region: TOBE_2; pfam08402 1183438007332 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1183438007333 active site 1183438007334 Double zinc ribbon; Region: DZR; pfam12773 1183438007335 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1183438007336 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1183438007337 phosphopeptide binding site; other site 1183438007338 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438007339 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1183438007340 structural tetrad; other site 1183438007341 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1183438007342 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1183438007343 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1183438007344 phage tail protein domain; Region: tail_TIGR02242 1183438007345 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1183438007346 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1183438007347 PhoD-like phosphatase; Region: PhoD; pfam09423 1183438007348 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1183438007349 putative active site [active] 1183438007350 putative metal binding site [ion binding]; other site 1183438007351 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1183438007352 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438007353 putative active site [active] 1183438007354 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1183438007355 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1183438007356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438007357 FeS/SAM binding site; other site 1183438007358 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1183438007359 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1183438007360 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1183438007361 G1 box; other site 1183438007362 GTP/Mg2+ binding site [chemical binding]; other site 1183438007363 Switch I region; other site 1183438007364 G2 box; other site 1183438007365 Switch II region; other site 1183438007366 G3 box; other site 1183438007367 G4 box; other site 1183438007368 G5 box; other site 1183438007369 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1183438007370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438007371 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1183438007372 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1183438007373 iron-sulfur cluster [ion binding]; other site 1183438007374 [2Fe-2S] cluster binding site [ion binding]; other site 1183438007375 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1183438007376 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1183438007377 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1183438007378 iron-sulfur cluster [ion binding]; other site 1183438007379 [2Fe-2S] cluster binding site [ion binding]; other site 1183438007380 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1183438007381 Rrf2 family protein; Region: rrf2_super; TIGR00738 1183438007382 Transcriptional regulator; Region: Rrf2; pfam02082 1183438007383 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1183438007384 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1183438007385 Qi binding site; other site 1183438007386 intrachain domain interface; other site 1183438007387 interchain domain interface [polypeptide binding]; other site 1183438007388 heme bH binding site [chemical binding]; other site 1183438007389 heme bL binding site [chemical binding]; other site 1183438007390 Qo binding site; other site 1183438007391 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1183438007392 interchain domain interface [polypeptide binding]; other site 1183438007393 intrachain domain interface; other site 1183438007394 Qi binding site; other site 1183438007395 Qo binding site; other site 1183438007396 FtsH Extracellular; Region: FtsH_ext; pfam06480 1183438007397 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1183438007398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438007399 Walker A motif; other site 1183438007400 ATP binding site [chemical binding]; other site 1183438007401 Walker B motif; other site 1183438007402 arginine finger; other site 1183438007403 Peptidase family M41; Region: Peptidase_M41; pfam01434 1183438007404 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1183438007405 Outer membrane efflux protein; Region: OEP; pfam02321 1183438007406 Outer membrane efflux protein; Region: OEP; pfam02321 1183438007407 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1183438007408 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1183438007409 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 1183438007410 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1183438007411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438007412 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1183438007413 active site 1183438007414 ATP binding site [chemical binding]; other site 1183438007415 substrate binding site [chemical binding]; other site 1183438007416 activation loop (A-loop); other site 1183438007417 Predicted integral membrane protein [Function unknown]; Region: COG5616 1183438007418 TPR repeat; Region: TPR_11; pfam13414 1183438007419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007420 binding surface 1183438007421 TPR motif; other site 1183438007422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007423 TPR motif; other site 1183438007424 binding surface 1183438007425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007426 binding surface 1183438007427 TPR motif; other site 1183438007428 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 1183438007429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438007430 DNA binding residues [nucleotide binding] 1183438007431 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1183438007432 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1183438007433 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1183438007434 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1183438007435 Walker A/P-loop; other site 1183438007436 ATP binding site [chemical binding]; other site 1183438007437 Q-loop/lid; other site 1183438007438 ABC transporter signature motif; other site 1183438007439 Walker B; other site 1183438007440 D-loop; other site 1183438007441 H-loop/switch region; other site 1183438007442 Sm and related proteins; Region: Sm_like; cl00259 1183438007443 heptamer interface [polypeptide binding]; other site 1183438007444 Sm1 motif; other site 1183438007445 hexamer interface [polypeptide binding]; other site 1183438007446 RNA binding site [nucleotide binding]; other site 1183438007447 Sm2 motif; other site 1183438007448 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1183438007449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438007450 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1183438007451 polyphosphate kinase; Provisional; Region: PRK05443 1183438007452 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1183438007453 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1183438007454 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1183438007455 putative domain interface [polypeptide binding]; other site 1183438007456 putative active site [active] 1183438007457 catalytic site [active] 1183438007458 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1183438007459 putative domain interface [polypeptide binding]; other site 1183438007460 putative active site [active] 1183438007461 catalytic site [active] 1183438007462 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1183438007463 active site 1183438007464 putative substrate binding region [chemical binding]; other site 1183438007465 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 1183438007466 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1183438007467 putative hydrophobic ligand binding site [chemical binding]; other site 1183438007468 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1183438007469 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1183438007470 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1183438007471 hydrophobic ligand binding site; other site 1183438007472 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1183438007473 putative catalytic residues [active] 1183438007474 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1183438007475 MoaE interaction surface [polypeptide binding]; other site 1183438007476 MoeB interaction surface [polypeptide binding]; other site 1183438007477 thiocarboxylated glycine; other site 1183438007478 threonine synthase; Validated; Region: PRK07591 1183438007479 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1183438007480 homodimer interface [polypeptide binding]; other site 1183438007481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438007482 catalytic residue [active] 1183438007483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438007484 Coenzyme A binding pocket [chemical binding]; other site 1183438007485 Clp protease ATP binding subunit; Region: clpC; CHL00095 1183438007486 Clp amino terminal domain; Region: Clp_N; pfam02861 1183438007487 Clp amino terminal domain; Region: Clp_N; pfam02861 1183438007488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438007489 Walker A motif; other site 1183438007490 ATP binding site [chemical binding]; other site 1183438007491 Walker B motif; other site 1183438007492 arginine finger; other site 1183438007493 UvrB/uvrC motif; Region: UVR; pfam02151 1183438007494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438007495 Walker A motif; other site 1183438007496 ATP binding site [chemical binding]; other site 1183438007497 Walker B motif; other site 1183438007498 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1183438007499 Domain of unknown function (DUF202); Region: DUF202; cl09954 1183438007500 glycogen branching enzyme; Provisional; Region: PRK05402 1183438007501 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1183438007502 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1183438007503 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1183438007504 active site 1183438007505 catalytic site [active] 1183438007506 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1183438007507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1183438007508 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1183438007509 Probable transposase; Region: OrfB_IS605; pfam01385 1183438007510 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1183438007511 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438007512 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1183438007513 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438007514 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1183438007515 conserved cys residue [active] 1183438007516 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1183438007517 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1183438007518 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1183438007519 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438007520 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1183438007521 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1183438007522 active site 1183438007523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007524 binding surface 1183438007525 TPR motif; other site 1183438007526 TPR repeat; Region: TPR_11; pfam13414 1183438007527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007528 binding surface 1183438007529 TPR motif; other site 1183438007530 TPR repeat; Region: TPR_11; pfam13414 1183438007531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007532 binding surface 1183438007533 TPR motif; other site 1183438007534 TPR repeat; Region: TPR_11; pfam13414 1183438007535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007536 TPR motif; other site 1183438007537 TPR repeat; Region: TPR_11; pfam13414 1183438007538 binding surface 1183438007539 Dienelactone hydrolase family; Region: DLH; pfam01738 1183438007540 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438007541 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 1183438007542 Predicted membrane protein [Function unknown]; Region: COG4244 1183438007543 short chain dehydrogenase; Provisional; Region: PRK07109 1183438007544 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1183438007545 putative NAD(P) binding site [chemical binding]; other site 1183438007546 active site 1183438007547 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1183438007548 maltose O-acetyltransferase; Provisional; Region: PRK10092 1183438007549 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1183438007550 active site 1183438007551 substrate binding site [chemical binding]; other site 1183438007552 trimer interface [polypeptide binding]; other site 1183438007553 CoA binding site [chemical binding]; other site 1183438007554 glycosyl transferase family protein; frameshifted 1183438007555 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438007556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438007557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438007558 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438007559 enolase; Provisional; Region: eno; PRK00077 1183438007560 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1183438007561 dimer interface [polypeptide binding]; other site 1183438007562 metal binding site [ion binding]; metal-binding site 1183438007563 substrate binding pocket [chemical binding]; other site 1183438007564 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1183438007565 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1183438007566 Ycf39; Provisional; Region: ycf39; CHL00194 1183438007567 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1183438007568 NAD(P) binding site [chemical binding]; other site 1183438007569 putative active site [active] 1183438007570 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1183438007571 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1183438007572 N-terminal plug; other site 1183438007573 ligand-binding site [chemical binding]; other site 1183438007574 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1183438007575 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1183438007576 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1183438007577 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1183438007578 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438007579 homoserine dehydrogenase; Provisional; Region: PRK06349 1183438007580 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1183438007581 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1183438007582 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1183438007583 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 1183438007584 putative homodimer interface [polypeptide binding]; other site 1183438007585 putative homotetramer interface [polypeptide binding]; other site 1183438007586 putative metal binding site [ion binding]; other site 1183438007587 putative homodimer-homodimer interface [polypeptide binding]; other site 1183438007588 putative allosteric switch controlling residues; other site 1183438007589 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1183438007590 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1183438007591 HflX GTPase family; Region: HflX; cd01878 1183438007592 G1 box; other site 1183438007593 GTP/Mg2+ binding site [chemical binding]; other site 1183438007594 Switch I region; other site 1183438007595 G2 box; other site 1183438007596 G3 box; other site 1183438007597 Switch II region; other site 1183438007598 G4 box; other site 1183438007599 G5 box; other site 1183438007600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438007601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438007602 active site 1183438007603 catalytic tetrad [active] 1183438007604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438007605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1183438007606 Walker A/P-loop; other site 1183438007607 ATP binding site [chemical binding]; other site 1183438007608 Q-loop/lid; other site 1183438007609 ABC transporter signature motif; other site 1183438007610 Walker B; other site 1183438007611 D-loop; other site 1183438007612 H-loop/switch region; other site 1183438007613 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1183438007614 active site 1183438007615 metal-binding site [ion binding] 1183438007616 nucleotide-binding site [chemical binding]; other site 1183438007617 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438007618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438007619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438007620 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438007621 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1183438007622 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1183438007623 Walker A/P-loop; other site 1183438007624 ATP binding site [chemical binding]; other site 1183438007625 Q-loop/lid; other site 1183438007626 ABC transporter signature motif; other site 1183438007627 Walker B; other site 1183438007628 D-loop; other site 1183438007629 H-loop/switch region; other site 1183438007630 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1183438007631 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1183438007632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438007633 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1183438007634 NAD(P) binding site [chemical binding]; other site 1183438007635 active site 1183438007636 sucrose synthase; Region: sucr_synth; TIGR02470 1183438007637 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1183438007638 putative ADP-binding pocket [chemical binding]; other site 1183438007639 phosphodiesterase YaeI; Provisional; Region: PRK11340 1183438007640 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1183438007641 putative active site [active] 1183438007642 putative metal binding site [ion binding]; other site 1183438007643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1183438007644 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14655 1183438007645 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1183438007646 Mg++ binding site [ion binding]; other site 1183438007647 putative catalytic motif [active] 1183438007648 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1183438007649 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1183438007650 dimer interface [polypeptide binding]; other site 1183438007651 putative functional site; other site 1183438007652 putative MPT binding site; other site 1183438007653 Clp amino terminal domain; Region: Clp_N; pfam02861 1183438007654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438007655 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1183438007656 Walker A/P-loop; other site 1183438007657 ATP binding site [chemical binding]; other site 1183438007658 Q-loop/lid; other site 1183438007659 ABC transporter signature motif; other site 1183438007660 Walker B; other site 1183438007661 D-loop; other site 1183438007662 H-loop/switch region; other site 1183438007663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007664 TPR motif; other site 1183438007665 TPR repeat; Region: TPR_11; pfam13414 1183438007666 binding surface 1183438007667 TPR repeat; Region: TPR_11; pfam13414 1183438007668 TPR repeat; Region: TPR_11; pfam13414 1183438007669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007670 binding surface 1183438007671 TPR motif; other site 1183438007672 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1183438007673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1183438007674 TPR motif; other site 1183438007675 binding surface 1183438007676 TPR repeat; Region: TPR_11; pfam13414 1183438007677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007678 binding surface 1183438007679 TPR motif; other site 1183438007680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007681 binding surface 1183438007682 TPR motif; other site 1183438007683 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1183438007684 Predicted transcriptional regulators [Transcription]; Region: COG1695 1183438007685 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1183438007686 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1183438007687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007688 binding surface 1183438007689 TPR motif; other site 1183438007690 TPR repeat; Region: TPR_11; pfam13414 1183438007691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007692 binding surface 1183438007693 TPR motif; other site 1183438007694 TPR repeat; Region: TPR_11; pfam13414 1183438007695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007696 TPR motif; other site 1183438007697 TPR repeat; Region: TPR_11; pfam13414 1183438007698 binding surface 1183438007699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1183438007700 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438007701 PBP superfamily domain; Region: PBP_like_2; cl17296 1183438007702 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1183438007703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007704 binding surface 1183438007705 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1183438007706 TPR motif; other site 1183438007707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007708 TPR motif; other site 1183438007709 TPR repeat; Region: TPR_11; pfam13414 1183438007710 binding surface 1183438007711 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438007712 Homeodomain-like domain; Region: HTH_23; cl17451 1183438007713 Winged helix-turn helix; Region: HTH_29; pfam13551 1183438007714 Homeodomain-like domain; Region: HTH_32; pfam13565 1183438007715 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1183438007716 PBP superfamily domain; Region: PBP_like_2; cl17296 1183438007717 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1183438007718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007719 binding surface 1183438007720 TPR motif; other site 1183438007721 TPR repeat; Region: TPR_11; pfam13414 1183438007722 TPR repeat; Region: TPR_11; pfam13414 1183438007723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007724 binding surface 1183438007725 TPR motif; other site 1183438007726 TPR repeat; Region: TPR_11; pfam13414 1183438007727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007728 binding surface 1183438007729 TPR motif; other site 1183438007730 TPR repeat; Region: TPR_11; pfam13414 1183438007731 TPR repeat; Region: TPR_11; pfam13414 1183438007732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007733 binding surface 1183438007734 TPR motif; other site 1183438007735 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438007736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007737 binding surface 1183438007738 TPR repeat; Region: TPR_11; pfam13414 1183438007739 TPR motif; other site 1183438007740 TPR repeat; Region: TPR_11; pfam13414 1183438007741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007742 binding surface 1183438007743 TPR motif; other site 1183438007744 TPR repeat; Region: TPR_11; pfam13414 1183438007745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1183438007746 TPR motif; other site 1183438007747 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438007748 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438007749 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438007750 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438007751 putative active site [active] 1183438007752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007753 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438007754 TPR motif; other site 1183438007755 binding surface 1183438007756 TPR repeat; Region: TPR_11; pfam13414 1183438007757 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1183438007758 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1183438007759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1183438007760 Walker A/P-loop; other site 1183438007761 ATP binding site [chemical binding]; other site 1183438007762 Q-loop/lid; other site 1183438007763 ABC transporter signature motif; other site 1183438007764 Walker B; other site 1183438007765 D-loop; other site 1183438007766 H-loop/switch region; other site 1183438007767 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1183438007768 B12 binding site [chemical binding]; other site 1183438007769 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1183438007770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438007771 FeS/SAM binding site; other site 1183438007772 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1183438007773 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1183438007774 Peptidase family U32; Region: Peptidase_U32; pfam01136 1183438007775 Collagenase; Region: DUF3656; pfam12392 1183438007776 Peptidase family U32; Region: Peptidase_U32; cl03113 1183438007777 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1183438007778 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1183438007779 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1183438007780 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1183438007781 active site 1183438007782 active site 1183438007783 TonB C terminal; Region: TonB_2; pfam13103 1183438007784 aspartate aminotransferase; Provisional; Region: PRK05764 1183438007785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1183438007786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438007787 homodimer interface [polypeptide binding]; other site 1183438007788 catalytic residue [active] 1183438007789 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1183438007790 GAF domain; Region: GAF; cl17456 1183438007791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438007792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438007793 dimer interface [polypeptide binding]; other site 1183438007794 phosphorylation site [posttranslational modification] 1183438007795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438007796 ATP binding site [chemical binding]; other site 1183438007797 Mg2+ binding site [ion binding]; other site 1183438007798 G-X-G motif; other site 1183438007799 glucokinase, proteobacterial type; Region: glk; TIGR00749 1183438007800 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1183438007801 nucleotide binding site [chemical binding]; other site 1183438007802 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1183438007803 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1183438007804 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1183438007805 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1183438007806 cell division protein; Validated; Region: ftsH; CHL00176 1183438007807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438007808 Walker A motif; other site 1183438007809 ATP binding site [chemical binding]; other site 1183438007810 Walker B motif; other site 1183438007811 arginine finger; other site 1183438007812 Peptidase family M41; Region: Peptidase_M41; pfam01434 1183438007813 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1183438007814 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1183438007815 putative active site [active] 1183438007816 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1183438007817 putative active site [active] 1183438007818 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1183438007819 active site 1183438007820 SAM binding site [chemical binding]; other site 1183438007821 homodimer interface [polypeptide binding]; other site 1183438007822 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438007823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438007824 active site 1183438007825 phosphorylation site [posttranslational modification] 1183438007826 intermolecular recognition site; other site 1183438007827 dimerization interface [polypeptide binding]; other site 1183438007828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438007829 DNA binding site [nucleotide binding] 1183438007830 Hpt domain; Region: Hpt; pfam01627 1183438007831 putative binding surface; other site 1183438007832 active site 1183438007833 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438007834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438007835 active site 1183438007836 phosphorylation site [posttranslational modification] 1183438007837 intermolecular recognition site; other site 1183438007838 dimerization interface [polypeptide binding]; other site 1183438007839 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1183438007840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1183438007841 metal binding site [ion binding]; metal-binding site 1183438007842 active site 1183438007843 I-site; other site 1183438007844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438007845 putative active site [active] 1183438007846 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438007847 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1183438007848 dimer interface [polypeptide binding]; other site 1183438007849 phosphorylation site [posttranslational modification] 1183438007850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438007851 ATP binding site [chemical binding]; other site 1183438007852 G-X-G motif; other site 1183438007853 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438007854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438007855 active site 1183438007856 phosphorylation site [posttranslational modification] 1183438007857 intermolecular recognition site; other site 1183438007858 dimerization interface [polypeptide binding]; other site 1183438007859 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1183438007860 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1183438007861 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1183438007862 metal ion-dependent adhesion site (MIDAS); other site 1183438007863 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1183438007864 Domain of unknown function DUF21; Region: DUF21; pfam01595 1183438007865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1183438007866 Transporter associated domain; Region: CorC_HlyC; smart01091 1183438007867 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438007868 Ligand Binding Site [chemical binding]; other site 1183438007869 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438007870 Ligand Binding Site [chemical binding]; other site 1183438007871 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1183438007872 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1183438007873 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1183438007874 putative active site [active] 1183438007875 substrate binding site [chemical binding]; other site 1183438007876 putative cosubstrate binding site; other site 1183438007877 catalytic site [active] 1183438007878 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1183438007879 substrate binding site [chemical binding]; other site 1183438007880 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1183438007881 rRNA interaction site [nucleotide binding]; other site 1183438007882 S8 interaction site; other site 1183438007883 putative laminin-1 binding site; other site 1183438007884 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1183438007885 UBA/TS-N domain; Region: UBA; pfam00627 1183438007886 Elongation factor TS; Region: EF_TS; pfam00889 1183438007887 Pirin-related protein [General function prediction only]; Region: COG1741 1183438007888 Pirin; Region: Pirin; pfam02678 1183438007889 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1183438007890 MarR family; Region: MarR; pfam01047 1183438007891 MarR family; Region: MarR_2; cl17246 1183438007892 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1183438007893 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1183438007894 minor groove reading motif; other site 1183438007895 helix-hairpin-helix signature motif; other site 1183438007896 substrate binding pocket [chemical binding]; other site 1183438007897 active site 1183438007898 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 1183438007899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1183438007900 DNA binding residues [nucleotide binding] 1183438007901 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1183438007902 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438007903 active site 1183438007904 ATP binding site [chemical binding]; other site 1183438007905 substrate binding site [chemical binding]; other site 1183438007906 activation loop (A-loop); other site 1183438007907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438007908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438007909 binding surface 1183438007910 TPR motif; other site 1183438007911 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438007912 Predicted transcriptional regulators [Transcription]; Region: COG1695 1183438007913 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1183438007914 CHASE2 domain; Region: CHASE2; pfam05226 1183438007915 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438007916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438007917 dimer interface [polypeptide binding]; other site 1183438007918 phosphorylation site [posttranslational modification] 1183438007919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438007920 ATP binding site [chemical binding]; other site 1183438007921 Mg2+ binding site [ion binding]; other site 1183438007922 G-X-G motif; other site 1183438007923 FecR protein; Region: FecR; pfam04773 1183438007924 CAAX protease self-immunity; Region: Abi; pfam02517 1183438007925 Protein of unknown function DUF72; Region: DUF72; pfam01904 1183438007926 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1183438007927 nucleoside/Zn binding site; other site 1183438007928 dimer interface [polypeptide binding]; other site 1183438007929 catalytic motif [active] 1183438007930 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1183438007931 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1183438007932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438007933 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1183438007934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438007935 DNA binding residues [nucleotide binding] 1183438007936 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1183438007937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438007938 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438007939 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1183438007940 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 1183438007941 L-aspartate oxidase; Provisional; Region: PRK06175 1183438007942 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1183438007943 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1183438007944 active site 1183438007945 DNA polymerase IV; Validated; Region: PRK02406 1183438007946 DNA binding site [nucleotide binding] 1183438007947 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1183438007948 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1183438007949 Beta-lactamase; Region: Beta-lactamase; pfam00144 1183438007950 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1183438007951 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1183438007952 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438007953 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 1183438007954 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1183438007955 HSP70 interaction site [polypeptide binding]; other site 1183438007956 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438007957 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438007958 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438007959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438007960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438007961 Cytochrome P450; Region: p450; cl12078 1183438007962 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1183438007963 Transposase; Region: HTH_Tnp_1; pfam01527 1183438007964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1183438007965 Integrase core domain; Region: rve; pfam00665 1183438007966 Integrase core domain; Region: rve_3; pfam13683 1183438007967 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438007968 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1183438007969 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1183438007970 hydrophobic ligand binding site; other site 1183438007971 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1183438007972 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438007973 KWG Leptospira; Region: KWG; pfam07656 1183438007974 KWG Leptospira; Region: KWG; pfam07656 1183438007975 Beta-lactamase; Region: Beta-lactamase; pfam00144 1183438007976 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1183438007977 Family description; Region: VCBS; pfam13517 1183438007978 Family description; Region: VCBS; pfam13517 1183438007979 Family description; Region: VCBS; pfam13517 1183438007980 Family description; Region: VCBS; pfam13517 1183438007981 Family description; Region: VCBS; pfam13517 1183438007982 Family description; Region: VCBS; pfam13517 1183438007983 Family description; Region: VCBS; pfam13517 1183438007984 Family description; Region: VCBS; pfam13517 1183438007985 Family description; Region: VCBS; pfam13517 1183438007986 Family description; Region: VCBS; pfam13517 1183438007987 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438007988 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438007989 putative active site [active] 1183438007990 Tic22-like family; Region: Tic22; cl04468 1183438007991 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438007992 putative active site [active] 1183438007993 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1183438007994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1183438007995 HAS barrel domain; Region: HAS-barrel; pfam09378 1183438007996 Domain of unknown function DUF87; Region: DUF87; pfam01935 1183438007997 AAA-like domain; Region: AAA_10; pfam12846 1183438007998 Beta-propeller repeat; Region: SBBP; pfam06739 1183438007999 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008000 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008001 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008002 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008003 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008004 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438008005 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008006 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008007 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008008 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008009 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008010 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008011 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438008012 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438008013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438008014 active site 1183438008015 phosphorylation site [posttranslational modification] 1183438008016 intermolecular recognition site; other site 1183438008017 dimerization interface [polypeptide binding]; other site 1183438008018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438008019 DNA binding residues [nucleotide binding] 1183438008020 dimerization interface [polypeptide binding]; other site 1183438008021 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 1183438008022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438008023 S-adenosylmethionine binding site [chemical binding]; other site 1183438008024 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 1183438008025 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438008026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438008027 active site 1183438008028 phosphorylation site [posttranslational modification] 1183438008029 intermolecular recognition site; other site 1183438008030 dimerization interface [polypeptide binding]; other site 1183438008031 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1183438008032 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1183438008033 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1183438008034 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438008035 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1183438008036 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1183438008037 ligand binding site [chemical binding]; other site 1183438008038 flexible hinge region; other site 1183438008039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438008040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438008041 ATP binding site [chemical binding]; other site 1183438008042 Mg2+ binding site [ion binding]; other site 1183438008043 G-X-G motif; other site 1183438008044 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1183438008045 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1183438008046 ligand binding site [chemical binding]; other site 1183438008047 flexible hinge region; other site 1183438008048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438008049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438008050 ATP binding site [chemical binding]; other site 1183438008051 Mg2+ binding site [ion binding]; other site 1183438008052 G-X-G motif; other site 1183438008053 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1183438008054 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1183438008055 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1183438008056 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1183438008057 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1183438008058 active site 1183438008059 dimer interface [polypeptide binding]; other site 1183438008060 metal binding site [ion binding]; metal-binding site 1183438008061 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438008062 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438008063 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438008064 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438008065 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438008066 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1183438008067 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1183438008068 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1183438008069 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1183438008070 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1183438008071 trimer interface [polypeptide binding]; other site 1183438008072 active site 1183438008073 substrate binding site [chemical binding]; other site 1183438008074 CoA binding site [chemical binding]; other site 1183438008075 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 1183438008076 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1183438008077 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1183438008078 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1183438008079 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1183438008080 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1183438008081 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438008082 putative active site [active] 1183438008083 tyrosine decarboxylase; Region: PLN02880 1183438008084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1183438008085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438008086 catalytic residue [active] 1183438008087 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1183438008088 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1183438008089 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1183438008090 Fasciclin domain; Region: Fasciclin; pfam02469 1183438008091 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1183438008092 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1183438008093 NAD(P) binding site [chemical binding]; other site 1183438008094 catalytic residues [active] 1183438008095 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438008096 putative active site [active] 1183438008097 PBP superfamily domain; Region: PBP_like_2; pfam12849 1183438008098 DNA primase; Validated; Region: dnaG; PRK05667 1183438008099 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1183438008100 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1183438008101 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1183438008102 active site 1183438008103 metal binding site [ion binding]; metal-binding site 1183438008104 interdomain interaction site; other site 1183438008105 CHASE3 domain; Region: CHASE3; pfam05227 1183438008106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438008107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1183438008108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438008109 ATP binding site [chemical binding]; other site 1183438008110 Mg2+ binding site [ion binding]; other site 1183438008111 G-X-G motif; other site 1183438008112 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438008113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438008114 active site 1183438008115 phosphorylation site [posttranslational modification] 1183438008116 intermolecular recognition site; other site 1183438008117 dimerization interface [polypeptide binding]; other site 1183438008118 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438008119 DNA binding residues [nucleotide binding] 1183438008120 dimerization interface [polypeptide binding]; other site 1183438008121 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1183438008122 PhoU domain; Region: PhoU; pfam01895 1183438008123 PhoU domain; Region: PhoU; pfam01895 1183438008124 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1183438008125 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1183438008126 transmembrane helices; other site 1183438008127 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1183438008128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438008129 active site 1183438008130 motif I; other site 1183438008131 motif II; other site 1183438008132 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1183438008133 lipoprotein signal peptidase; Provisional; Region: PRK14787 1183438008134 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1183438008135 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1183438008136 inhibitor-cofactor binding pocket; inhibition site 1183438008137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438008138 catalytic residue [active] 1183438008139 gamma-glutamyl kinase; Provisional; Region: PRK05429 1183438008140 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1183438008141 nucleotide binding site [chemical binding]; other site 1183438008142 homotetrameric interface [polypeptide binding]; other site 1183438008143 putative phosphate binding site [ion binding]; other site 1183438008144 putative allosteric binding site; other site 1183438008145 PUA domain; Region: PUA; pfam01472 1183438008146 Mediator complex subunit MED14; Region: Med14; pfam08638 1183438008147 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1183438008148 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1183438008149 cofactor binding site; other site 1183438008150 DNA binding site [nucleotide binding] 1183438008151 substrate interaction site [chemical binding]; other site 1183438008152 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1183438008153 Helix-turn-helix domain; Region: HTH_17; pfam12728 1183438008154 Peptidase family M1; Region: Peptidase_M1; pfam01433 1183438008155 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1183438008156 Zn binding site [ion binding]; other site 1183438008157 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1183438008158 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438008159 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1183438008160 active site 1183438008161 metal binding site [ion binding]; metal-binding site 1183438008162 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1183438008163 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1183438008164 putative active site [active] 1183438008165 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1183438008166 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1183438008167 putative NAD(P) binding site [chemical binding]; other site 1183438008168 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1183438008169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438008170 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1183438008171 endonuclease III; Region: ENDO3c; smart00478 1183438008172 minor groove reading motif; other site 1183438008173 helix-hairpin-helix signature motif; other site 1183438008174 substrate binding pocket [chemical binding]; other site 1183438008175 active site 1183438008176 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438008177 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438008178 active site 1183438008179 ATP binding site [chemical binding]; other site 1183438008180 substrate binding site [chemical binding]; other site 1183438008181 activation loop (A-loop); other site 1183438008182 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1183438008183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438008184 dimerization interface [polypeptide binding]; other site 1183438008185 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1183438008186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438008187 dimerization interface [polypeptide binding]; other site 1183438008188 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1183438008189 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1183438008190 membrane-bound complex binding site; other site 1183438008191 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1183438008192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438008193 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438008194 dimerization interface [polypeptide binding]; other site 1183438008195 DNA binding residues [nucleotide binding] 1183438008196 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1183438008197 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1183438008198 putative active site [active] 1183438008199 catalytic triad [active] 1183438008200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438008201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438008202 ATP binding site [chemical binding]; other site 1183438008203 Mg2+ binding site [ion binding]; other site 1183438008204 G-X-G motif; other site 1183438008205 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1183438008206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438008207 active site 1183438008208 phosphorylation site [posttranslational modification] 1183438008209 intermolecular recognition site; other site 1183438008210 dimerization interface [polypeptide binding]; other site 1183438008211 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1183438008212 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 1183438008213 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1183438008214 dimer interface [polypeptide binding]; other site 1183438008215 RNA polymerase sigma factor; Provisional; Region: PRK12518 1183438008216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438008217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438008218 DNA binding residues [nucleotide binding] 1183438008219 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1183438008220 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1183438008221 dimer interface [polypeptide binding]; other site 1183438008222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438008223 catalytic residue [active] 1183438008224 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1183438008225 FOG: CBS domain [General function prediction only]; Region: COG0517 1183438008226 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1183438008227 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1183438008228 homodimer interface [polypeptide binding]; other site 1183438008229 substrate-cofactor binding pocket; other site 1183438008230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438008231 catalytic residue [active] 1183438008232 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1183438008233 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1183438008234 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1183438008235 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1183438008236 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1183438008237 NADH dehydrogenase; frameshifted 1183438008238 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 1183438008239 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1183438008240 catalytic core [active] 1183438008241 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008242 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008243 Homeodomain-like domain; Region: HTH_23; cl17451 1183438008244 Winged helix-turn helix; Region: HTH_29; pfam13551 1183438008245 Homeodomain-like domain; Region: HTH_32; pfam13565 1183438008246 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1183438008247 Beta-propeller repeat; Region: SBBP; pfam06739 1183438008248 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438008249 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1183438008250 Subunit I/III interface [polypeptide binding]; other site 1183438008251 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1183438008252 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1183438008253 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1183438008254 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1183438008255 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1183438008256 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1183438008257 Predicted membrane protein [Function unknown]; Region: COG4244 1183438008258 Predicted membrane protein [Function unknown]; Region: COG4244 1183438008259 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 1183438008260 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1183438008261 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1183438008262 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1183438008263 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 1183438008264 TPR repeat; Region: TPR_11; pfam13414 1183438008265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438008266 binding surface 1183438008267 TPR motif; other site 1183438008268 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438008269 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1183438008270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438008271 putative substrate translocation pore; other site 1183438008272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438008273 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1183438008274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1183438008275 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1183438008276 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1183438008277 putative GSH binding site [chemical binding]; other site 1183438008278 catalytic residues [active] 1183438008279 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1183438008280 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1183438008281 homodimer interface [polypeptide binding]; other site 1183438008282 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1183438008283 active site pocket [active] 1183438008284 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438008285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438008286 dimer interface [polypeptide binding]; other site 1183438008287 phosphorylation site [posttranslational modification] 1183438008288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438008289 ATP binding site [chemical binding]; other site 1183438008290 Mg2+ binding site [ion binding]; other site 1183438008291 G-X-G motif; other site 1183438008292 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438008293 putative active site [active] 1183438008294 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 1183438008295 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1183438008296 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1183438008297 active site 1183438008298 catalytic residues [active] 1183438008299 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1183438008300 periplasmic protein; Provisional; Region: PRK10568 1183438008301 Ycf46; Provisional; Region: ycf46; CHL00195 1183438008302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438008303 Walker A motif; other site 1183438008304 ATP binding site [chemical binding]; other site 1183438008305 Walker B motif; other site 1183438008306 arginine finger; other site 1183438008307 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 1183438008308 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1183438008309 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 1183438008310 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1183438008311 nucleotide binding site [chemical binding]; other site 1183438008312 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1183438008313 SBD interface [polypeptide binding]; other site 1183438008314 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1183438008315 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 1183438008316 yiaA/B two helix domain; Region: YiaAB; cl01759 1183438008317 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1183438008318 Caspase domain; Region: Peptidase_C14; pfam00656 1183438008319 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1183438008320 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1183438008321 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1183438008322 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1183438008323 active site 1183438008324 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1183438008325 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cl01244 1183438008326 cofactor binding site; other site 1183438008327 metal binding site [ion binding]; metal-binding site 1183438008328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1183438008329 kynureninase; Region: kynureninase; TIGR01814 1183438008330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438008331 catalytic residue [active] 1183438008332 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438008333 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438008334 active site 1183438008335 ATP binding site [chemical binding]; other site 1183438008336 substrate binding site [chemical binding]; other site 1183438008337 activation loop (A-loop); other site 1183438008338 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1183438008339 Cytochrome P450; Region: p450; cl12078 1183438008340 Predicted flavoprotein [General function prediction only]; Region: COG0431 1183438008341 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1183438008342 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1183438008343 hypothetical protein; Provisional; Region: PRK07208 1183438008344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438008345 UDP-galactopyranose mutase; Region: GLF; pfam03275 1183438008346 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1183438008347 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1183438008348 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438008349 Phosphotransferase enzyme family; Region: APH; pfam01636 1183438008350 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1183438008351 active site 1183438008352 ATP binding site [chemical binding]; other site 1183438008353 substrate binding site [chemical binding]; other site 1183438008354 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1183438008355 SmpB-tmRNA interface; other site 1183438008356 Predicted transcriptional regulators [Transcription]; Region: COG1733 1183438008357 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1183438008358 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1183438008359 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1183438008360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1183438008361 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1183438008362 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1183438008363 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1183438008364 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1183438008365 shikimate binding site; other site 1183438008366 NAD(P) binding site [chemical binding]; other site 1183438008367 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 1183438008368 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1183438008369 PYR/PP interface [polypeptide binding]; other site 1183438008370 dimer interface [polypeptide binding]; other site 1183438008371 TPP binding site [chemical binding]; other site 1183438008372 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1183438008373 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1183438008374 TPP-binding site [chemical binding]; other site 1183438008375 dimer interface [polypeptide binding]; other site 1183438008376 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1183438008377 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1183438008378 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1183438008379 GDP-binding site [chemical binding]; other site 1183438008380 ACT binding site; other site 1183438008381 IMP binding site; other site 1183438008382 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 1183438008383 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1183438008384 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1183438008385 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1183438008386 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1183438008387 glutamine binding [chemical binding]; other site 1183438008388 catalytic triad [active] 1183438008389 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 1183438008390 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1183438008391 feedback inhibition sensing region; other site 1183438008392 homohexameric interface [polypeptide binding]; other site 1183438008393 nucleotide binding site [chemical binding]; other site 1183438008394 N-acetyl-L-glutamate binding site [chemical binding]; other site 1183438008395 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1183438008396 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1183438008397 NAD(P) binding site [chemical binding]; other site 1183438008398 putative active site [active] 1183438008399 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 1183438008400 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1183438008401 active site 1183438008402 PHP Thumb interface [polypeptide binding]; other site 1183438008403 metal binding site [ion binding]; metal-binding site 1183438008404 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1183438008405 generic binding surface I; other site 1183438008406 generic binding surface II; other site 1183438008407 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1183438008408 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1183438008409 ligand binding site [chemical binding]; other site 1183438008410 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1183438008411 putative switch regulator; other site 1183438008412 non-specific DNA interactions [nucleotide binding]; other site 1183438008413 DNA binding site [nucleotide binding] 1183438008414 sequence specific DNA binding site [nucleotide binding]; other site 1183438008415 putative cAMP binding site [chemical binding]; other site 1183438008416 NIL domain; Region: NIL; cl09633 1183438008417 sulfite reductase subunit beta; Provisional; Region: PRK13504 1183438008418 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1183438008419 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1183438008420 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1183438008421 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1183438008422 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 1183438008423 reactive center loop; other site 1183438008424 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1183438008425 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1183438008426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1183438008427 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1183438008428 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1183438008429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1183438008430 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1183438008431 dimerization interface [polypeptide binding]; other site 1183438008432 substrate binding pocket [chemical binding]; other site 1183438008433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438008434 Coenzyme A binding pocket [chemical binding]; other site 1183438008435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1183438008436 dimerization interface [polypeptide binding]; other site 1183438008437 putative DNA binding site [nucleotide binding]; other site 1183438008438 putative Zn2+ binding site [ion binding]; other site 1183438008439 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1183438008440 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438008441 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438008442 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438008443 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 1183438008444 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1183438008445 active site 1183438008446 dimer interface [polypeptide binding]; other site 1183438008447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438008448 active site 1183438008449 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1183438008450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438008451 motif II; other site 1183438008452 acetolactate synthase; Reviewed; Region: PRK08322 1183438008453 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1183438008454 PYR/PP interface [polypeptide binding]; other site 1183438008455 dimer interface [polypeptide binding]; other site 1183438008456 TPP binding site [chemical binding]; other site 1183438008457 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1183438008458 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1183438008459 TPP-binding site [chemical binding]; other site 1183438008460 dimer interface [polypeptide binding]; other site 1183438008461 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1183438008462 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1183438008463 NAD(P) binding site [chemical binding]; other site 1183438008464 catalytic residues [active] 1183438008465 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 1183438008466 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1183438008467 Part of AAA domain; Region: AAA_19; pfam13245 1183438008468 Family description; Region: UvrD_C_2; pfam13538 1183438008469 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 1183438008470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438008471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438008472 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1183438008473 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1183438008474 oligomer interface [polypeptide binding]; other site 1183438008475 metal binding site [ion binding]; metal-binding site 1183438008476 metal binding site [ion binding]; metal-binding site 1183438008477 Cl binding site [ion binding]; other site 1183438008478 aspartate ring; other site 1183438008479 basic sphincter; other site 1183438008480 putative hydrophobic gate; other site 1183438008481 periplasmic entrance; other site 1183438008482 CpeS-like protein; Region: CpeS; pfam09367 1183438008483 acetyl-CoA synthetase; Provisional; Region: PRK00174 1183438008484 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1183438008485 active site 1183438008486 CoA binding site [chemical binding]; other site 1183438008487 acyl-activating enzyme (AAE) consensus motif; other site 1183438008488 AMP binding site [chemical binding]; other site 1183438008489 acetate binding site [chemical binding]; other site 1183438008490 ribosomal protein S20; Region: rps20; CHL00102 1183438008491 Transglycosylase; Region: Transgly; pfam00912 1183438008492 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1183438008493 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1183438008494 translation initiation factor Sui1; Validated; Region: PRK06824 1183438008495 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1183438008496 putative rRNA binding site [nucleotide binding]; other site 1183438008497 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438008498 putative active site [active] 1183438008499 Rhomboid family; Region: Rhomboid; pfam01694 1183438008500 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1183438008501 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1183438008502 active site 1183438008503 NTP binding site [chemical binding]; other site 1183438008504 metal binding triad [ion binding]; metal-binding site 1183438008505 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1183438008506 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1183438008507 Zn2+ binding site [ion binding]; other site 1183438008508 Mg2+ binding site [ion binding]; other site 1183438008509 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1183438008510 RNA recognition motif; Region: RRM; smart00360 1183438008511 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1183438008512 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1183438008513 putative tRNA-binding site [nucleotide binding]; other site 1183438008514 B3/4 domain; Region: B3_4; pfam03483 1183438008515 tRNA synthetase B5 domain; Region: B5; smart00874 1183438008516 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1183438008517 dimer interface [polypeptide binding]; other site 1183438008518 motif 1; other site 1183438008519 motif 3; other site 1183438008520 motif 2; other site 1183438008521 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1183438008522 MraW methylase family; Region: Methyltransf_5; cl17771 1183438008523 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1183438008524 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1183438008525 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1183438008526 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1183438008527 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1183438008528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438008529 S-adenosylmethionine binding site [chemical binding]; other site 1183438008530 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1183438008531 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1183438008532 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438008533 putative active site [active] 1183438008534 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1183438008535 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 1183438008536 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1183438008537 TPR repeat; Region: TPR_11; pfam13414 1183438008538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438008539 binding surface 1183438008540 TPR motif; other site 1183438008541 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1183438008542 TPR repeat; Region: TPR_11; pfam13414 1183438008543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438008544 TPR motif; other site 1183438008545 binding surface 1183438008546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438008547 TPR motif; other site 1183438008548 binding surface 1183438008549 TPR repeat; Region: TPR_11; pfam13414 1183438008550 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1183438008551 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1183438008552 SLBB domain; Region: SLBB; pfam10531 1183438008553 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 1183438008554 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1183438008555 substrate binding site; other site 1183438008556 metal-binding site 1183438008557 Oligomer interface; other site 1183438008558 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438008559 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1183438008560 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1183438008561 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1183438008562 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1183438008563 NAD binding site [chemical binding]; other site 1183438008564 substrate binding site [chemical binding]; other site 1183438008565 homodimer interface [polypeptide binding]; other site 1183438008566 active site 1183438008567 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1183438008568 NADP binding site [chemical binding]; other site 1183438008569 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1183438008570 active site 1183438008571 putative substrate binding site [chemical binding]; other site 1183438008572 GTP-binding protein YchF; Reviewed; Region: PRK09601 1183438008573 YchF GTPase; Region: YchF; cd01900 1183438008574 G1 box; other site 1183438008575 GTP/Mg2+ binding site [chemical binding]; other site 1183438008576 Switch I region; other site 1183438008577 G2 box; other site 1183438008578 Switch II region; other site 1183438008579 G3 box; other site 1183438008580 G4 box; other site 1183438008581 G5 box; other site 1183438008582 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1183438008583 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1183438008584 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1183438008585 short chain dehydrogenase; Provisional; Region: PRK07454 1183438008586 NADP binding site [chemical binding]; other site 1183438008587 substrate binding site [chemical binding]; other site 1183438008588 active site 1183438008589 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1183438008590 Cytochrome P450; Region: p450; cl12078 1183438008591 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1183438008592 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1183438008593 fructokinase; Reviewed; Region: PRK09557 1183438008594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1183438008595 nucleotide binding site [chemical binding]; other site 1183438008596 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1183438008597 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1183438008598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438008599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438008600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438008601 active site 1183438008602 catalytic tetrad [active] 1183438008603 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438008604 Serine hydrolase; Region: Ser_hydrolase; cl17834 1183438008605 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1183438008606 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1183438008607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1183438008608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438008609 catalytic residue [active] 1183438008610 Predicted membrane protein [Function unknown]; Region: COG4270 1183438008611 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1183438008612 Caspase domain; Region: Peptidase_C14; pfam00656 1183438008613 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438008614 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438008615 structural tetrad; other site 1183438008616 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438008617 structural tetrad; other site 1183438008618 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1183438008619 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438008620 catalytic motif [active] 1183438008621 Catalytic residue [active] 1183438008622 Aspartyl protease; Region: Asp_protease_2; pfam13650 1183438008623 inhibitor binding site; inhibition site 1183438008624 catalytic motif [active] 1183438008625 Catalytic residue [active] 1183438008626 Active site flap [active] 1183438008627 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438008628 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1183438008629 dihydropteroate synthase; Region: DHPS; TIGR01496 1183438008630 substrate binding pocket [chemical binding]; other site 1183438008631 dimer interface [polypeptide binding]; other site 1183438008632 inhibitor binding site; inhibition site 1183438008633 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1183438008634 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1183438008635 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1183438008636 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1183438008637 active site 1183438008638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1183438008639 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1183438008640 [2Fe-2S] cluster binding site [ion binding]; other site 1183438008641 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1183438008642 alpha subunit interface [polypeptide binding]; other site 1183438008643 active site 1183438008644 substrate binding site [chemical binding]; other site 1183438008645 Fe binding site [ion binding]; other site 1183438008646 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1183438008647 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1183438008648 RDD family; Region: RDD; pfam06271 1183438008649 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 1183438008650 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1183438008651 Rubredoxin; Region: Rubredoxin; pfam00301 1183438008652 iron binding site [ion binding]; other site 1183438008653 Ycf48-like protein; Provisional; Region: PRK13684 1183438008654 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 1183438008655 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 1183438008656 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 1183438008657 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 1183438008658 PsbL protein; Region: PsbL; pfam02419 1183438008659 photosystem II reaction center protein J; Provisional; Region: PRK02565 1183438008660 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 1183438008661 putative ligand binding site [chemical binding]; other site 1183438008662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1183438008663 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1183438008664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438008665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1183438008666 active site 1183438008667 phosphorylation site [posttranslational modification] 1183438008668 intermolecular recognition site; other site 1183438008669 dimerization interface [polypeptide binding]; other site 1183438008670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438008671 DNA binding residues [nucleotide binding] 1183438008672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438008673 active site 1183438008674 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 1183438008675 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1183438008676 Peptidase family M28; Region: Peptidase_M28; pfam04389 1183438008677 metal binding site [ion binding]; metal-binding site 1183438008678 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1183438008679 Interdomain contacts; other site 1183438008680 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1183438008681 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1183438008682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1183438008683 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1183438008684 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1183438008685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438008686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438008687 dimer interface [polypeptide binding]; other site 1183438008688 phosphorylation site [posttranslational modification] 1183438008689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438008690 ATP binding site [chemical binding]; other site 1183438008691 Mg2+ binding site [ion binding]; other site 1183438008692 G-X-G motif; other site 1183438008693 cheY-homologous receiver domain; Region: REC; smart00448 1183438008694 phosphorylation site [posttranslational modification] 1183438008695 tellurite resistance protein terB; Region: terB; cd07176 1183438008696 putative metal binding site [ion binding]; other site 1183438008697 GMP synthase; Reviewed; Region: guaA; PRK00074 1183438008698 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1183438008699 AMP/PPi binding site [chemical binding]; other site 1183438008700 candidate oxyanion hole; other site 1183438008701 catalytic triad [active] 1183438008702 potential glutamine specificity residues [chemical binding]; other site 1183438008703 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1183438008704 ATP Binding subdomain [chemical binding]; other site 1183438008705 Ligand Binding sites [chemical binding]; other site 1183438008706 Dimerization subdomain; other site 1183438008707 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1183438008708 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1183438008709 putative active site cavity [active] 1183438008710 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1183438008711 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1183438008712 substrate binding site [chemical binding]; other site 1183438008713 active site 1183438008714 catalytic residues [active] 1183438008715 heterodimer interface [polypeptide binding]; other site 1183438008716 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1183438008717 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1183438008718 interface (dimer of trimers) [polypeptide binding]; other site 1183438008719 Substrate-binding/catalytic site; other site 1183438008720 Zn-binding sites [ion binding]; other site 1183438008721 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1183438008722 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2933 1183438008723 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1183438008724 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1183438008725 DHH family; Region: DHH; pfam01368 1183438008726 DHHA1 domain; Region: DHHA1; pfam02272 1183438008727 DNA gyrase subunit A; Validated; Region: PRK05560 1183438008728 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1183438008729 CAP-like domain; other site 1183438008730 active site 1183438008731 primary dimer interface [polypeptide binding]; other site 1183438008732 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1183438008733 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1183438008734 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 1183438008735 EVE domain; Region: EVE; cl00728 1183438008736 HEAT repeats; Region: HEAT_2; pfam13646 1183438008737 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1183438008738 HEAT repeats; Region: HEAT_2; pfam13646 1183438008739 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1183438008740 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1183438008741 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1183438008742 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 1183438008743 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1183438008744 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1183438008745 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 1183438008746 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1183438008747 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1183438008748 putative acyl-acceptor binding pocket; other site 1183438008749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438008750 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1183438008751 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1183438008752 active site 1183438008753 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 1183438008754 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 1183438008755 active site 1183438008756 (T/H)XGH motif; other site 1183438008757 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1183438008758 nudix motif; other site 1183438008759 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1183438008760 active site 1183438008761 dimer interface [polypeptide binding]; other site 1183438008762 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1183438008763 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1183438008764 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1183438008765 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1183438008766 Ligand Binding Site [chemical binding]; other site 1183438008767 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438008768 Ligand Binding Site [chemical binding]; other site 1183438008769 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1183438008770 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1183438008771 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1183438008772 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1183438008773 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1183438008774 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1183438008775 NAD synthetase; Provisional; Region: PRK13981 1183438008776 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1183438008777 multimer interface [polypeptide binding]; other site 1183438008778 active site 1183438008779 catalytic triad [active] 1183438008780 protein interface 1 [polypeptide binding]; other site 1183438008781 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1183438008782 homodimer interface [polypeptide binding]; other site 1183438008783 NAD binding pocket [chemical binding]; other site 1183438008784 ATP binding pocket [chemical binding]; other site 1183438008785 Mg binding site [ion binding]; other site 1183438008786 active-site loop [active] 1183438008787 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1183438008788 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1183438008789 N-terminal plug; other site 1183438008790 ligand-binding site [chemical binding]; other site 1183438008791 CHAT domain; Region: CHAT; pfam12770 1183438008792 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438008793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438008794 binding surface 1183438008795 TPR motif; other site 1183438008796 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438008797 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438008798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438008799 binding surface 1183438008800 TPR motif; other site 1183438008801 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438008802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438008803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438008804 binding surface 1183438008805 TPR motif; other site 1183438008806 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438008807 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1183438008808 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1183438008809 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1183438008810 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1183438008811 active site 1183438008812 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1183438008813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1183438008814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438008815 AAA domain; Region: AAA_21; pfam13304 1183438008816 Walker A/P-loop; other site 1183438008817 ATP binding site [chemical binding]; other site 1183438008818 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1183438008819 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1183438008820 putative C-terminal domain interface [polypeptide binding]; other site 1183438008821 putative GSH binding site (G-site) [chemical binding]; other site 1183438008822 putative dimer interface [polypeptide binding]; other site 1183438008823 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1183438008824 N-terminal domain interface [polypeptide binding]; other site 1183438008825 dimer interface [polypeptide binding]; other site 1183438008826 substrate binding pocket (H-site) [chemical binding]; other site 1183438008827 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1183438008828 active site 1183438008829 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1183438008830 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1183438008831 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1183438008832 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 1183438008833 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1183438008834 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1183438008835 active site 1183438008836 catalytic site [active] 1183438008837 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1183438008838 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1183438008839 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 1183438008840 HEAT repeats; Region: HEAT_2; pfam13646 1183438008841 HEAT repeats; Region: HEAT_2; pfam13646 1183438008842 Family description; Region: VCBS; pfam13517 1183438008843 FG-GAP repeat; Region: FG-GAP; pfam01839 1183438008844 Family description; Region: VCBS; pfam13517 1183438008845 Family description; Region: VCBS; pfam13517 1183438008846 Family description; Region: VCBS; pfam13517 1183438008847 Family description; Region: VCBS; pfam13517 1183438008848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438008849 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438008850 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438008851 active site 1183438008852 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438008853 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1183438008854 active site 1183438008855 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1183438008856 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1183438008857 MoxR-like ATPases [General function prediction only]; Region: COG0714 1183438008858 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1183438008859 Walker A motif; other site 1183438008860 ATP binding site [chemical binding]; other site 1183438008861 Walker B motif; other site 1183438008862 arginine finger; other site 1183438008863 PAS fold; Region: PAS_3; pfam08447 1183438008864 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438008865 putative active site [active] 1183438008866 heme pocket [chemical binding]; other site 1183438008867 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438008868 PAS fold; Region: PAS_3; pfam08447 1183438008869 putative active site [active] 1183438008870 heme pocket [chemical binding]; other site 1183438008871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438008872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438008873 dimer interface [polypeptide binding]; other site 1183438008874 phosphorylation site [posttranslational modification] 1183438008875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438008876 ATP binding site [chemical binding]; other site 1183438008877 Mg2+ binding site [ion binding]; other site 1183438008878 G-X-G motif; other site 1183438008879 SnoaL-like domain; Region: SnoaL_4; pfam13577 1183438008880 EamA-like transporter family; Region: EamA; pfam00892 1183438008881 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1183438008882 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 1183438008883 Protein of unknown function (DUF790); Region: DUF790; pfam05626 1183438008884 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1183438008885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438008886 ATP binding site [chemical binding]; other site 1183438008887 putative Mg++ binding site [ion binding]; other site 1183438008888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438008889 nucleotide binding region [chemical binding]; other site 1183438008890 ATP-binding site [chemical binding]; other site 1183438008891 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1183438008892 Predicted transcriptional regulators [Transcription]; Region: COG1695 1183438008893 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1183438008894 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438008895 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1183438008896 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438008897 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1183438008898 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1183438008899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1183438008900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438008901 Coenzyme A binding pocket [chemical binding]; other site 1183438008902 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1183438008903 active site 1183438008904 catalytic residues [active] 1183438008905 metal binding site [ion binding]; metal-binding site 1183438008906 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1183438008907 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1183438008908 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1183438008909 catalytic site [active] 1183438008910 subunit interface [polypeptide binding]; other site 1183438008911 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 1183438008912 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1183438008913 IHF dimer interface [polypeptide binding]; other site 1183438008914 IHF - DNA interface [nucleotide binding]; other site 1183438008915 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438008916 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1183438008917 catalytic site [active] 1183438008918 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1183438008919 homotrimer interaction site [polypeptide binding]; other site 1183438008920 zinc binding site [ion binding]; other site 1183438008921 CDP-binding sites; other site 1183438008922 BON domain; Region: BON; pfam04972 1183438008923 Peptidase family M48; Region: Peptidase_M48; pfam01435 1183438008924 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1183438008925 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1183438008926 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1183438008927 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1183438008928 putative di-iron ligands [ion binding]; other site 1183438008929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438008930 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1183438008931 NAD(P) binding site [chemical binding]; other site 1183438008932 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1183438008933 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1183438008934 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 1183438008935 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438008936 catalytic residues [active] 1183438008937 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438008938 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438008939 active site 1183438008940 ATP binding site [chemical binding]; other site 1183438008941 substrate binding site [chemical binding]; other site 1183438008942 activation loop (A-loop); other site 1183438008943 anthranilate synthase component I; Provisional; Region: PRK13565 1183438008944 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1183438008945 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1183438008946 YCII-related domain; Region: YCII; cl00999 1183438008947 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1183438008948 AAA ATPase domain; Region: AAA_16; pfam13191 1183438008949 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1183438008950 Peptidase family M50; Region: Peptidase_M50; pfam02163 1183438008951 active site 1183438008952 putative substrate binding region [chemical binding]; other site 1183438008953 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1183438008954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438008955 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1183438008956 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1183438008957 active site 1183438008958 NTP binding site [chemical binding]; other site 1183438008959 metal binding triad [ion binding]; metal-binding site 1183438008960 antibiotic binding site [chemical binding]; other site 1183438008961 Protein of unknown function DUF86; Region: DUF86; cl01031 1183438008962 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1183438008963 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1183438008964 active site 1183438008965 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1183438008966 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 1183438008967 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1183438008968 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1183438008969 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1183438008970 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1183438008971 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1183438008972 Sulfatase; Region: Sulfatase; cl17466 1183438008973 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1183438008974 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438008975 putative active site [active] 1183438008976 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1183438008977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1183438008978 substrate binding pocket [chemical binding]; other site 1183438008979 membrane-bound complex binding site; other site 1183438008980 hinge residues; other site 1183438008981 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1183438008982 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1183438008983 active site 1183438008984 dimer interface [polypeptide binding]; other site 1183438008985 non-prolyl cis peptide bond; other site 1183438008986 insertion regions; other site 1183438008987 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1183438008988 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1183438008989 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1183438008990 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1183438008991 H+ Antiporter protein; Region: 2A0121; TIGR00900 1183438008992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438008993 putative substrate translocation pore; other site 1183438008994 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1183438008995 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1183438008996 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1183438008997 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1183438008998 active site 1183438008999 trimer interface [polypeptide binding]; other site 1183438009000 dimer interface [polypeptide binding]; other site 1183438009001 competence damage-inducible protein A; Provisional; Region: PRK00549 1183438009002 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1183438009003 putative MPT binding site; other site 1183438009004 Competence-damaged protein; Region: CinA; pfam02464 1183438009005 TIGR03032 family protein; Region: TIGR03032 1183438009006 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438009007 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438009008 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438009009 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438009010 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1183438009011 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1183438009012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438009013 homodimer interface [polypeptide binding]; other site 1183438009014 catalytic residue [active] 1183438009015 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1183438009016 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438009017 active site 1183438009018 ATP binding site [chemical binding]; other site 1183438009019 substrate binding site [chemical binding]; other site 1183438009020 activation loop (A-loop); other site 1183438009021 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1183438009022 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1183438009023 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 1183438009024 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1183438009025 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1183438009026 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1183438009027 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1183438009028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438009029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438009030 ATP binding site [chemical binding]; other site 1183438009031 Mg2+ binding site [ion binding]; other site 1183438009032 G-X-G motif; other site 1183438009033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438009034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438009035 active site 1183438009036 phosphorylation site [posttranslational modification] 1183438009037 intermolecular recognition site; other site 1183438009038 dimerization interface [polypeptide binding]; other site 1183438009039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438009040 DNA binding residues [nucleotide binding] 1183438009041 dimerization interface [polypeptide binding]; other site 1183438009042 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438009043 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1183438009044 O-Antigen ligase; Region: Wzy_C; pfam04932 1183438009045 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1183438009046 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1183438009047 active site 1183438009048 Substrate binding site; other site 1183438009049 Mg++ binding site; other site 1183438009050 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438009051 putative trimer interface [polypeptide binding]; other site 1183438009052 putative CoA binding site [chemical binding]; other site 1183438009053 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1183438009054 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 1183438009055 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 1183438009056 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1183438009057 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1183438009058 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1183438009059 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1183438009060 Catalytic site [active] 1183438009061 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1183438009062 active site 1183438009063 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1183438009064 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1183438009065 tetramer interface [polypeptide binding]; other site 1183438009066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438009067 catalytic residue [active] 1183438009068 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 1183438009069 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1183438009070 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1183438009071 folate binding site [chemical binding]; other site 1183438009072 NADP+ binding site [chemical binding]; other site 1183438009073 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 1183438009074 putative active site [active] 1183438009075 Zn binding site [ion binding]; other site 1183438009076 H+ Antiporter protein; Region: 2A0121; TIGR00900 1183438009077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438009078 putative substrate translocation pore; other site 1183438009079 Integrase core domain; Region: rve; pfam00665 1183438009080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1183438009081 Integrase core domain; Region: rve_3; pfam13683 1183438009082 Clp amino terminal domain; Region: Clp_N; pfam02861 1183438009083 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1183438009084 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1183438009085 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1183438009086 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1183438009087 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1183438009088 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1183438009089 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1183438009090 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1183438009091 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1183438009092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438009093 S-adenosylmethionine binding site [chemical binding]; other site 1183438009094 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1183438009095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438009096 ATP binding site [chemical binding]; other site 1183438009097 putative Mg++ binding site [ion binding]; other site 1183438009098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438009099 nucleotide binding region [chemical binding]; other site 1183438009100 ATP-binding site [chemical binding]; other site 1183438009101 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1183438009102 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1183438009103 active site 1183438009104 Zn binding site [ion binding]; other site 1183438009105 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1183438009106 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1183438009107 active site 1183438009108 Zn binding site [ion binding]; other site 1183438009109 Inward rectifier potassium channel; Region: IRK; pfam01007 1183438009110 hydrolase; Region: PLN02578 1183438009111 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1183438009112 C-terminal peptidase (prc); Region: prc; TIGR00225 1183438009113 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438009114 protein binding site [polypeptide binding]; other site 1183438009115 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1183438009116 Catalytic dyad [active] 1183438009117 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1183438009118 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1183438009119 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1183438009120 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1183438009121 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1183438009122 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1183438009123 E-class dimer interface [polypeptide binding]; other site 1183438009124 P-class dimer interface [polypeptide binding]; other site 1183438009125 active site 1183438009126 Cu2+ binding site [ion binding]; other site 1183438009127 Zn2+ binding site [ion binding]; other site 1183438009128 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438009129 putative active site [active] 1183438009130 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438009131 Family description; Region: VCBS; pfam13517 1183438009132 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438009133 Family description; Region: VCBS; pfam13517 1183438009134 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1183438009135 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1183438009136 2-isopropylmalate synthase; Validated; Region: PRK00915 1183438009137 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1183438009138 active site 1183438009139 catalytic residues [active] 1183438009140 metal binding site [ion binding]; metal-binding site 1183438009141 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1183438009142 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438009143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438009144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438009145 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438009146 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1183438009147 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438009148 Integral membrane protein TerC family; Region: TerC; cl10468 1183438009149 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1183438009150 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1183438009151 AAA domain; Region: AAA_30; pfam13604 1183438009152 Family description; Region: UvrD_C_2; pfam13538 1183438009153 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438009154 putative active site [active] 1183438009155 putative catalytic triad [active] 1183438009156 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1183438009157 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438009158 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1183438009159 active site 1183438009160 Protein phosphatase 2C; Region: PP2C; pfam00481 1183438009161 Protein kinase domain; Region: Pkinase; pfam00069 1183438009162 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438009163 active site 1183438009164 ATP binding site [chemical binding]; other site 1183438009165 substrate binding site [chemical binding]; other site 1183438009166 activation loop (A-loop); other site 1183438009167 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 1183438009168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438009169 DNA binding residues [nucleotide binding] 1183438009170 benzoate transport; Region: 2A0115; TIGR00895 1183438009171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438009172 putative substrate translocation pore; other site 1183438009173 GAF domain; Region: GAF_3; pfam13492 1183438009174 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1183438009175 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1183438009176 metal binding site [ion binding]; metal-binding site 1183438009177 active site 1183438009178 I-site; other site 1183438009179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1183438009180 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1183438009181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1183438009182 Protein of unknown function (DUF2656); Region: DUF2656; pfam10847 1183438009183 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1183438009184 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1183438009185 DNA binding site [nucleotide binding] 1183438009186 active site 1183438009187 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1183438009188 Helix-turn-helix domain; Region: HTH_18; pfam12833 1183438009189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438009190 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1183438009191 active site 1183438009192 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1183438009193 AAA ATPase domain; Region: AAA_16; pfam13191 1183438009194 Walker A motif; other site 1183438009195 ATP binding site [chemical binding]; other site 1183438009196 Walker B motif; other site 1183438009197 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438009198 putative active site [active] 1183438009199 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1183438009200 FAD binding domain; Region: FAD_binding_4; pfam01565 1183438009201 Berberine and berberine like; Region: BBE; pfam08031 1183438009202 O-methyltransferase; Region: Methyltransf_2; pfam00891 1183438009203 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1183438009204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438009205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438009206 PAS domain; Region: PAS_9; pfam13426 1183438009207 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1183438009208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1183438009209 Histidine kinase; Region: HisKA_3; pfam07730 1183438009210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438009211 ATP binding site [chemical binding]; other site 1183438009212 Mg2+ binding site [ion binding]; other site 1183438009213 G-X-G motif; other site 1183438009214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438009215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438009216 active site 1183438009217 phosphorylation site [posttranslational modification] 1183438009218 intermolecular recognition site; other site 1183438009219 dimerization interface [polypeptide binding]; other site 1183438009220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438009221 DNA binding residues [nucleotide binding] 1183438009222 dimerization interface [polypeptide binding]; other site 1183438009223 Thioredoxin; Region: Thioredoxin_4; cl17273 1183438009224 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1183438009225 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1183438009226 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1183438009227 Walker A/P-loop; other site 1183438009228 ATP binding site [chemical binding]; other site 1183438009229 Q-loop/lid; other site 1183438009230 ABC transporter signature motif; other site 1183438009231 Walker B; other site 1183438009232 D-loop; other site 1183438009233 H-loop/switch region; other site 1183438009234 BON domain; Region: BON; pfam04972 1183438009235 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1183438009236 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1183438009237 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1183438009238 active site 1183438009239 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1183438009240 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1183438009241 Walker A motif; other site 1183438009242 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1183438009243 protein-splicing catalytic site; other site 1183438009244 thioester formation/cholesterol transfer; other site 1183438009245 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1183438009246 protein-splicing catalytic site; other site 1183438009247 replicative DNA helicase; Region: DnaB; TIGR00665 1183438009248 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1183438009249 ATP binding site [chemical binding]; other site 1183438009250 Walker B motif; other site 1183438009251 DNA binding loops [nucleotide binding] 1183438009252 Asparaginase [Amino acid transport and metabolism]; Region: COG1446 1183438009253 dimer interface [polypeptide binding]; other site 1183438009254 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438009255 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438009256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438009257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438009258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438009259 ribosomal protein S18; Region: rps18; CHL00077 1183438009260 ribosomal protein L33; Region: rpl33; CHL00104 1183438009261 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1183438009262 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1183438009263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438009264 dimer interface [polypeptide binding]; other site 1183438009265 conserved gate region; other site 1183438009266 putative PBP binding loops; other site 1183438009267 ABC-ATPase subunit interface; other site 1183438009268 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1183438009269 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1183438009270 Walker A/P-loop; other site 1183438009271 ATP binding site [chemical binding]; other site 1183438009272 Q-loop/lid; other site 1183438009273 ABC transporter signature motif; other site 1183438009274 Walker B; other site 1183438009275 D-loop; other site 1183438009276 H-loop/switch region; other site 1183438009277 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1183438009278 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1183438009279 substrate binding pocket [chemical binding]; other site 1183438009280 membrane-bound complex binding site; other site 1183438009281 aspartate kinase; Provisional; Region: PRK07431 1183438009282 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1183438009283 putative catalytic residues [active] 1183438009284 putative nucleotide binding site [chemical binding]; other site 1183438009285 putative aspartate binding site [chemical binding]; other site 1183438009286 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1183438009287 putative allosteric regulatory site; other site 1183438009288 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1183438009289 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1183438009290 putative allosteric regulatory site; other site 1183438009291 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1183438009292 putative allosteric regulatory residue; other site 1183438009293 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1183438009294 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1183438009295 active site 1183438009296 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1183438009297 active site 1183438009298 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438009299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438009300 active site 1183438009301 phosphorylation site [posttranslational modification] 1183438009302 intermolecular recognition site; other site 1183438009303 dimerization interface [polypeptide binding]; other site 1183438009304 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438009305 DNA binding residues [nucleotide binding] 1183438009306 dimerization interface [polypeptide binding]; other site 1183438009307 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1183438009308 AMP binding site [chemical binding]; other site 1183438009309 metal binding site [ion binding]; metal-binding site 1183438009310 active site 1183438009311 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1183438009312 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1183438009313 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1183438009314 dimer interface [polypeptide binding]; other site 1183438009315 motif 1; other site 1183438009316 active site 1183438009317 motif 2; other site 1183438009318 motif 3; other site 1183438009319 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1183438009320 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1183438009321 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438009322 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1183438009323 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1183438009324 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1183438009325 catalytic residue [active] 1183438009326 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1183438009327 RNA methyltransferase, RsmE family; Region: TIGR00046 1183438009328 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1183438009329 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1183438009330 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1183438009331 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1183438009332 active site 1183438009333 catalytic site [active] 1183438009334 geranylgeranyl reductase; Region: ChlP; TIGR02028 1183438009335 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1183438009336 tandem repeat interface [polypeptide binding]; other site 1183438009337 oligomer interface [polypeptide binding]; other site 1183438009338 active site residues [active] 1183438009339 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1183438009340 tandem repeat interface [polypeptide binding]; other site 1183438009341 oligomer interface [polypeptide binding]; other site 1183438009342 active site residues [active] 1183438009343 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1183438009344 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1183438009345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438009346 S-adenosylmethionine binding site [chemical binding]; other site 1183438009347 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1183438009348 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1183438009349 putative RNA binding site [nucleotide binding]; other site 1183438009350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438009351 S-adenosylmethionine binding site [chemical binding]; other site 1183438009352 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1183438009353 MoaE interaction surface [polypeptide binding]; other site 1183438009354 MoeB interaction surface [polypeptide binding]; other site 1183438009355 thiocarboxylated glycine; other site 1183438009356 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1183438009357 MoaE homodimer interface [polypeptide binding]; other site 1183438009358 MoaD interaction [polypeptide binding]; other site 1183438009359 active site residues [active] 1183438009360 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1183438009361 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1183438009362 dimer interface [polypeptide binding]; other site 1183438009363 active site 1183438009364 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1183438009365 folate binding site [chemical binding]; other site 1183438009366 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1183438009367 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1183438009368 SLBB domain; Region: SLBB; pfam10531 1183438009369 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1183438009370 Chain length determinant protein; Region: Wzz; pfam02706 1183438009371 Chain length determinant protein; Region: Wzz; cl15801 1183438009372 AAA domain; Region: AAA_31; pfam13614 1183438009373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1183438009374 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1183438009375 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1183438009376 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1183438009377 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1183438009378 Walker A/P-loop; other site 1183438009379 ATP binding site [chemical binding]; other site 1183438009380 Q-loop/lid; other site 1183438009381 ABC transporter signature motif; other site 1183438009382 Walker B; other site 1183438009383 D-loop; other site 1183438009384 H-loop/switch region; other site 1183438009385 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1183438009386 putative carbohydrate binding site [chemical binding]; other site 1183438009387 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1183438009388 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1183438009389 Probable Catalytic site; other site 1183438009390 metal-binding site 1183438009391 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1183438009392 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438009393 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438009394 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1183438009395 metal-binding site 1183438009396 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438009397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438009398 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1183438009399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438009400 active site 1183438009401 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1183438009402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438009403 S-adenosylmethionine binding site [chemical binding]; other site 1183438009404 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438009405 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1183438009406 active site 1183438009407 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 1183438009408 DDE superfamily endonuclease; Region: DDE_4; cl17710 1183438009409 hypothetical protein; Provisional; Region: PRK06126 1183438009410 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1183438009411 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1183438009412 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1183438009413 DNA photolyase; Region: DNA_photolyase; pfam00875 1183438009414 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1183438009415 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1183438009416 NADP binding site [chemical binding]; other site 1183438009417 Predicted transcriptional regulators [Transcription]; Region: COG1733 1183438009418 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1183438009419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438009420 Walker B; other site 1183438009421 D-loop; other site 1183438009422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1183438009423 Zn2+ binding site [ion binding]; other site 1183438009424 Mg2+ binding site [ion binding]; other site 1183438009425 haloalkane dehalogenase; Provisional; Region: PRK00870 1183438009426 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1183438009427 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1183438009428 conserved cys residue [active] 1183438009429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438009430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438009431 hypothetical protein; Validated; Region: PRK00110 1183438009432 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1183438009433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438009434 Mg2+ binding site [ion binding]; other site 1183438009435 G-X-G motif; other site 1183438009436 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1183438009437 anchoring element; other site 1183438009438 dimer interface [polypeptide binding]; other site 1183438009439 ATP binding site [chemical binding]; other site 1183438009440 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1183438009441 active site 1183438009442 putative metal-binding site [ion binding]; other site 1183438009443 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1183438009444 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1183438009445 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1183438009446 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1183438009447 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1183438009448 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1183438009449 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1183438009450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1183438009451 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1183438009452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009453 TPR motif; other site 1183438009454 TPR repeat; Region: TPR_11; pfam13414 1183438009455 binding surface 1183438009456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009457 binding surface 1183438009458 TPR motif; other site 1183438009459 TPR repeat; Region: TPR_11; pfam13414 1183438009460 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1183438009461 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1183438009462 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1183438009463 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1183438009464 metal binding site [ion binding]; metal-binding site 1183438009465 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 1183438009466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009467 binding surface 1183438009468 TPR repeat; Region: TPR_11; pfam13414 1183438009469 TPR motif; other site 1183438009470 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 1183438009471 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1183438009472 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438009473 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1183438009474 cellulose synthase-interactive protein; Provisional; Region: PLN03200 1183438009475 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438009476 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1183438009477 active site 1183438009478 metal binding site [ion binding]; metal-binding site 1183438009479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438009480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438009481 dimer interface [polypeptide binding]; other site 1183438009482 phosphorylation site [posttranslational modification] 1183438009483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438009484 ATP binding site [chemical binding]; other site 1183438009485 Mg2+ binding site [ion binding]; other site 1183438009486 G-X-G motif; other site 1183438009487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438009488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438009489 active site 1183438009490 phosphorylation site [posttranslational modification] 1183438009491 intermolecular recognition site; other site 1183438009492 dimerization interface [polypeptide binding]; other site 1183438009493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438009494 DNA binding site [nucleotide binding] 1183438009495 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1183438009496 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1183438009497 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1183438009498 YGGT family; Region: YGGT; pfam02325 1183438009499 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 1183438009500 active site 1183438009501 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1183438009502 SnoaL-like domain; Region: SnoaL_2; pfam12680 1183438009503 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1183438009504 MarR family; Region: MarR_2; pfam12802 1183438009505 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 1183438009506 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1183438009507 Di-iron ligands [ion binding]; other site 1183438009508 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1183438009509 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1183438009510 homodimer interface [polypeptide binding]; other site 1183438009511 active site 1183438009512 SAM binding site [chemical binding]; other site 1183438009513 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1183438009514 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1183438009515 active site 1183438009516 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1183438009517 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1183438009518 RF-1 domain; Region: RF-1; pfam00472 1183438009519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438009520 DNA binding residues [nucleotide binding] 1183438009521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 1183438009522 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1183438009523 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1183438009524 P loop; other site 1183438009525 Nucleotide binding site [chemical binding]; other site 1183438009526 DTAP/Switch II; other site 1183438009527 Switch I; other site 1183438009528 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1183438009529 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1183438009530 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438009531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438009532 S-adenosylmethionine binding site [chemical binding]; other site 1183438009533 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 1183438009534 putative active site [active] 1183438009535 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1183438009536 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1183438009537 homodimer interface [polypeptide binding]; other site 1183438009538 substrate-cofactor binding pocket; other site 1183438009539 catalytic residue [active] 1183438009540 Dihaem cytochrome c; Region: DHC; pfam09626 1183438009541 ferrochelatase; Reviewed; Region: hemH; PRK00035 1183438009542 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1183438009543 C-terminal domain interface [polypeptide binding]; other site 1183438009544 active site 1183438009545 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1183438009546 active site 1183438009547 N-terminal domain interface [polypeptide binding]; other site 1183438009548 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1183438009549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1183438009550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438009551 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1183438009552 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1183438009553 putative NAD(P) binding site [chemical binding]; other site 1183438009554 catalytic Zn binding site [ion binding]; other site 1183438009555 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1183438009556 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 1183438009557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438009558 protoporphyrinogen oxidase; Region: PLN02576 1183438009559 transposase; fragment 1183438009560 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 1183438009561 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 1183438009562 Chorismate lyase; Region: Chor_lyase; cl01230 1183438009563 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1183438009564 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1183438009565 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1183438009566 Type II/IV secretion system protein; Region: T2SE; pfam00437 1183438009567 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1183438009568 Walker A motif; other site 1183438009569 ATP binding site [chemical binding]; other site 1183438009570 Walker B motif; other site 1183438009571 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1183438009572 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1183438009573 ligand binding site [chemical binding]; other site 1183438009574 flexible hinge region; other site 1183438009575 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1183438009576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1183438009577 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1183438009578 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1183438009579 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1183438009580 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1183438009581 Peptidase S46; Region: Peptidase_S46; pfam10459 1183438009582 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1183438009583 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1183438009584 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1183438009585 Phosphotransferase enzyme family; Region: APH; pfam01636 1183438009586 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1183438009587 active site 1183438009588 ATP binding site [chemical binding]; other site 1183438009589 hypothetical protein; Provisional; Region: PRK10593 1183438009590 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1183438009591 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1183438009592 active site 1183438009593 CAAX protease self-immunity; Region: Abi; pfam02517 1183438009594 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1183438009595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438009596 motif II; other site 1183438009597 hypothetical protein; Provisional; Region: PRK13683 1183438009598 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1183438009599 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1183438009600 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1183438009601 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1183438009602 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1183438009603 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1183438009604 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1183438009605 putative active site [active] 1183438009606 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438009607 putative active site [active] 1183438009608 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1183438009609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1183438009610 RNA binding surface [nucleotide binding]; other site 1183438009611 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1183438009612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1183438009613 catalytic loop [active] 1183438009614 iron binding site [ion binding]; other site 1183438009615 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1183438009616 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1183438009617 homotetramer interface [polypeptide binding]; other site 1183438009618 ligand binding site [chemical binding]; other site 1183438009619 catalytic site [active] 1183438009620 NAD binding site [chemical binding]; other site 1183438009621 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1183438009622 B12 binding site [chemical binding]; other site 1183438009623 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1183438009624 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1183438009625 Phosphoglycerate kinase; Region: PGK; pfam00162 1183438009626 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1183438009627 substrate binding site [chemical binding]; other site 1183438009628 hinge regions; other site 1183438009629 ADP binding site [chemical binding]; other site 1183438009630 catalytic site [active] 1183438009631 acyl carrier protein; Provisional; Region: acpP; PRK00982 1183438009632 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 1183438009633 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 1183438009634 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1183438009635 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 1183438009636 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1183438009637 dinuclear metal binding motif [ion binding]; other site 1183438009638 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1183438009639 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1183438009640 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1183438009641 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1183438009642 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1183438009643 propionate/acetate kinase; Provisional; Region: PRK12379 1183438009644 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438009645 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1183438009646 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438009647 Ion channel; Region: Ion_trans_2; pfam07885 1183438009648 VanW like protein; Region: VanW; pfam04294 1183438009649 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1183438009650 MG2 domain; Region: A2M_N; pfam01835 1183438009651 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1183438009652 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1183438009653 CARDB; Region: CARDB; pfam07705 1183438009654 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1183438009655 surface patch; other site 1183438009656 thioester region; other site 1183438009657 specificity defining residues; other site 1183438009658 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1183438009659 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1183438009660 nucleotide binding pocket [chemical binding]; other site 1183438009661 K-X-D-G motif; other site 1183438009662 catalytic site [active] 1183438009663 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1183438009664 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1183438009665 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1183438009666 Dimer interface [polypeptide binding]; other site 1183438009667 BRCT sequence motif; other site 1183438009668 S-layer homology domain; Region: SLH; pfam00395 1183438009669 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1183438009670 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1183438009671 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1183438009672 PA/protease or protease-like domain interface [polypeptide binding]; other site 1183438009673 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 1183438009674 Peptidase family M28; Region: Peptidase_M28; pfam04389 1183438009675 metal binding site [ion binding]; metal-binding site 1183438009676 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1183438009677 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1183438009678 DsrE/DsrF-like family; Region: DrsE; pfam02635 1183438009679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438009680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438009681 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1183438009682 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1183438009683 active site 1183438009684 homodimer interface [polypeptide binding]; other site 1183438009685 catalytic site [active] 1183438009686 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1183438009687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1183438009688 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1183438009689 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438009690 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1183438009691 active site 1183438009692 metal binding site [ion binding]; metal-binding site 1183438009693 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1183438009694 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1183438009695 catalytic residue [active] 1183438009696 putative FPP diphosphate binding site; other site 1183438009697 putative FPP binding hydrophobic cleft; other site 1183438009698 dimer interface [polypeptide binding]; other site 1183438009699 putative IPP diphosphate binding site; other site 1183438009700 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1183438009701 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1183438009702 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1183438009703 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1183438009704 active site 1183438009705 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1183438009706 substrate binding site [chemical binding]; other site 1183438009707 catalytic residues [active] 1183438009708 dimer interface [polypeptide binding]; other site 1183438009709 Predicted transcriptional regulators [Transcription]; Region: COG1695 1183438009710 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1183438009711 AAA domain; Region: AAA_30; pfam13604 1183438009712 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1183438009713 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1183438009714 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1183438009715 hypothetical protein; fragment 1183438009716 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438009717 Tetratricopeptide repeat; Region: TPR_10; cl17452 1183438009718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438009719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009720 binding surface 1183438009721 TPR motif; other site 1183438009722 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438009723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438009724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009725 binding surface 1183438009726 TPR motif; other site 1183438009727 Integrase core domain; Region: rve; pfam00665 1183438009728 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1183438009729 Integrase core domain; Region: rve_3; pfam13683 1183438009730 transposase; frameshifted 1183438009731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1183438009732 Integrase core domain; Region: rve; pfam00665 1183438009733 Integrase core domain; Region: rve_3; pfam13683 1183438009734 Transposase; Region: HTH_Tnp_1; pfam01527 1183438009735 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1183438009736 MOSC domain; Region: MOSC; pfam03473 1183438009737 Cupin domain; Region: Cupin_2; pfam07883 1183438009738 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1183438009739 active site 1183438009740 catalytic residues [active] 1183438009741 DNA binding site [nucleotide binding] 1183438009742 Int/Topo IB signature motif; other site 1183438009743 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1183438009744 FAD binding domain; Region: FAD_binding_4; pfam01565 1183438009745 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 1183438009746 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1183438009747 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1183438009748 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1183438009749 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1183438009750 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438009751 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1183438009752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009753 TPR motif; other site 1183438009754 binding surface 1183438009755 TPR repeat; Region: TPR_11; pfam13414 1183438009756 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1183438009757 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1183438009758 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438009759 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1183438009760 putative ADP-binding pocket [chemical binding]; other site 1183438009761 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1183438009762 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1183438009763 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1183438009764 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1183438009765 quinone interaction residues [chemical binding]; other site 1183438009766 active site 1183438009767 catalytic residues [active] 1183438009768 FMN binding site [chemical binding]; other site 1183438009769 substrate binding site [chemical binding]; other site 1183438009770 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1183438009771 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1183438009772 MOSC domain; Region: MOSC; pfam03473 1183438009773 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438009774 putative active site [active] 1183438009775 DNA gyrase subunit A; Validated; Region: PRK05560 1183438009776 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1183438009777 CAP-like domain; other site 1183438009778 active site 1183438009779 primary dimer interface [polypeptide binding]; other site 1183438009780 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1183438009781 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1183438009782 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1183438009783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1183438009784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1183438009785 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1183438009786 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1183438009787 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1183438009788 active site 1183438009789 Substrate binding site; other site 1183438009790 Mg++ binding site; other site 1183438009791 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438009792 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 1183438009793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438009794 FeS/SAM binding site; other site 1183438009795 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1183438009796 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1183438009797 putative active site [active] 1183438009798 UGMP family protein; Validated; Region: PRK09604 1183438009799 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1183438009800 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 1183438009801 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 1183438009802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438009803 motif II; other site 1183438009804 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1183438009805 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1183438009806 FAD binding domain; Region: FAD_binding_4; pfam01565 1183438009807 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1183438009808 Cysteine-rich domain; Region: CCG; pfam02754 1183438009809 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438009810 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1183438009811 active site 1183438009812 AAA ATPase domain; Region: AAA_16; pfam13191 1183438009813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1183438009814 putative DNA binding site [nucleotide binding]; other site 1183438009815 putative Zn2+ binding site [ion binding]; other site 1183438009816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438009817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009818 binding surface 1183438009819 TPR motif; other site 1183438009820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009821 binding surface 1183438009822 TPR motif; other site 1183438009823 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438009824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438009825 binding surface 1183438009826 TPR motif; other site 1183438009827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438009828 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1183438009829 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1183438009830 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438009831 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1183438009832 active site 1183438009833 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1183438009834 tetramerization interface [polypeptide binding]; other site 1183438009835 active site 1183438009836 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1183438009837 dimer interface [polypeptide binding]; other site 1183438009838 substrate binding site [chemical binding]; other site 1183438009839 metal binding sites [ion binding]; metal-binding site 1183438009840 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1183438009841 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1183438009842 phosphate binding site [ion binding]; other site 1183438009843 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1183438009844 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1183438009845 active site 1183438009846 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1183438009847 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1183438009848 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1183438009849 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1183438009850 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1183438009851 putative NADP binding site [chemical binding]; other site 1183438009852 active site 1183438009853 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1183438009854 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1183438009855 active site 1183438009856 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1183438009857 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1183438009858 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1183438009859 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1183438009860 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1183438009861 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1183438009862 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1183438009863 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1183438009864 active site 1183438009865 catalytic site [active] 1183438009866 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1183438009867 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 1183438009868 starch-binding site 2 [chemical binding]; other site 1183438009869 starch-binding site 1 [chemical binding]; other site 1183438009870 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1183438009871 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1183438009872 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1183438009873 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1183438009874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438009875 Coenzyme A binding pocket [chemical binding]; other site 1183438009876 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1183438009877 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1183438009878 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1183438009879 Mg++ binding site [ion binding]; other site 1183438009880 putative catalytic motif [active] 1183438009881 substrate binding site [chemical binding]; other site 1183438009882 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1183438009883 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1183438009884 dimerization interface [polypeptide binding]; other site 1183438009885 ligand binding site [chemical binding]; other site 1183438009886 DNA topoisomerase I; Validated; Region: PRK06599 1183438009887 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1183438009888 active site 1183438009889 interdomain interaction site; other site 1183438009890 putative metal-binding site [ion binding]; other site 1183438009891 nucleotide binding site [chemical binding]; other site 1183438009892 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1183438009893 domain I; other site 1183438009894 DNA binding groove [nucleotide binding] 1183438009895 phosphate binding site [ion binding]; other site 1183438009896 domain II; other site 1183438009897 domain III; other site 1183438009898 nucleotide binding site [chemical binding]; other site 1183438009899 catalytic site [active] 1183438009900 domain IV; other site 1183438009901 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1183438009902 classical (c) SDRs; Region: SDR_c; cd05233 1183438009903 NAD(P) binding site [chemical binding]; other site 1183438009904 active site 1183438009905 mobile mystery protein A; Region: mob_myst_A; TIGR02612 1183438009906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438009907 non-specific DNA binding site [nucleotide binding]; other site 1183438009908 salt bridge; other site 1183438009909 sequence-specific DNA binding site [nucleotide binding]; other site 1183438009910 mobile mystery protein B; Region: mob_myst_B; TIGR02613 1183438009911 Fic/DOC family; Region: Fic; pfam02661 1183438009912 Fic/DOC family; Region: Fic; cl00960 1183438009913 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1183438009914 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1183438009915 HIGH motif; other site 1183438009916 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1183438009917 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1183438009918 active site 1183438009919 KMSKS motif; other site 1183438009920 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1183438009921 tRNA binding surface [nucleotide binding]; other site 1183438009922 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1183438009923 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1183438009924 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1183438009925 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1183438009926 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1183438009927 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1183438009928 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1183438009929 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 1183438009930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1183438009931 inhibitor-cofactor binding pocket; inhibition site 1183438009932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438009933 catalytic residue [active] 1183438009934 Predicted ATPase [General function prediction only]; Region: COG4637 1183438009935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438009936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438009937 Walker A/P-loop; other site 1183438009938 Walker A/P-loop; other site 1183438009939 ATP binding site [chemical binding]; other site 1183438009940 ATP binding site [chemical binding]; other site 1183438009941 hypothetical protein; frameshifted 1183438009942 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1183438009943 pheophytin binding site; other site 1183438009944 chlorophyll binding site; other site 1183438009945 quinone binding site; other site 1183438009946 Fe binding site [ion binding]; other site 1183438009947 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1183438009948 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1183438009949 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1183438009950 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1183438009951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1183438009952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438009953 Coenzyme A binding pocket [chemical binding]; other site 1183438009954 Putative zinc-finger; Region: zf-HC2; pfam13490 1183438009955 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1183438009956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438009957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438009958 DNA binding residues [nucleotide binding] 1183438009959 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 1183438009960 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 1183438009961 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1183438009962 PBP superfamily domain; Region: PBP_like_2; pfam12849 1183438009963 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1183438009964 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1183438009965 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1183438009966 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1183438009967 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1183438009968 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1183438009969 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1183438009970 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1183438009971 active site 1183438009972 DNA binding site [nucleotide binding] 1183438009973 Int/Topo IB signature motif; other site 1183438009974 catalytic residues [active] 1183438009975 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1183438009976 active site residue [active] 1183438009977 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438009978 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438009979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438009980 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438009981 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1183438009982 active site 1183438009983 Trp docking motif [polypeptide binding]; other site 1183438009984 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1183438009985 active site 1183438009986 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1183438009987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1183438009988 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438009989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438009990 active site 1183438009991 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1183438009992 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1183438009993 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1183438009994 Surface antigen; Region: Bac_surface_Ag; pfam01103 1183438009995 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1183438009996 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1183438009997 CHAT domain; Region: CHAT; cl17868 1183438009998 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1183438009999 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1183438010000 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1183438010001 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1183438010002 CHASE2 domain; Region: CHASE2; pfam05226 1183438010003 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438010004 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438010005 active site 1183438010006 ATP binding site [chemical binding]; other site 1183438010007 substrate binding site [chemical binding]; other site 1183438010008 activation loop (A-loop); other site 1183438010009 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1183438010010 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1183438010011 Walker A/P-loop; other site 1183438010012 ATP binding site [chemical binding]; other site 1183438010013 Q-loop/lid; other site 1183438010014 ABC transporter signature motif; other site 1183438010015 Walker B; other site 1183438010016 D-loop; other site 1183438010017 H-loop/switch region; other site 1183438010018 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438010019 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1183438010020 FtsX-like permease family; Region: FtsX; pfam02687 1183438010021 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438010022 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1183438010023 FtsX-like permease family; Region: FtsX; pfam02687 1183438010024 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438010025 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438010026 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1183438010027 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438010028 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1183438010029 Catalytic site [active] 1183438010030 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1183438010031 Predicted methyltransferase [General function prediction only]; Region: COG4798 1183438010032 S-adenosylmethionine binding site [chemical binding]; other site 1183438010033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438010034 Walker A motif; other site 1183438010035 ATP binding site [chemical binding]; other site 1183438010036 Walker B motif; other site 1183438010037 arginine finger; other site 1183438010038 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1183438010039 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1183438010040 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1183438010041 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438010042 catalytic motif [active] 1183438010043 Catalytic residue [active] 1183438010044 Aspartyl protease; Region: Asp_protease_2; pfam13650 1183438010045 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438010046 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240 1183438010047 putative active site [active] 1183438010048 Zn binding site [ion binding]; other site 1183438010049 hypothetical protein; frameshifted 1183438010050 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1183438010051 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1183438010052 GTP binding site; other site 1183438010053 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1183438010054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438010055 S-adenosylmethionine binding site [chemical binding]; other site 1183438010056 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1183438010057 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438010058 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1183438010059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438010060 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1183438010061 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1183438010062 Homeodomain-like domain; Region: HTH_23; cl17451 1183438010063 Winged helix-turn helix; Region: HTH_29; pfam13551 1183438010064 Homeodomain-like domain; Region: HTH_32; pfam13565 1183438010065 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1183438010066 SNF2 Helicase protein; Region: DUF3670; pfam12419 1183438010067 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1183438010068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438010069 ATP binding site [chemical binding]; other site 1183438010070 putative Mg++ binding site [ion binding]; other site 1183438010071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438010072 nucleotide binding region [chemical binding]; other site 1183438010073 ATP-binding site [chemical binding]; other site 1183438010074 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1183438010075 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 1183438010076 SWIM zinc finger; Region: SWIM; pfam04434 1183438010077 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1183438010078 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438010079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438010080 active site 1183438010081 phosphorylation site [posttranslational modification] 1183438010082 intermolecular recognition site; other site 1183438010083 dimerization interface [polypeptide binding]; other site 1183438010084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1183438010085 dimer interface [polypeptide binding]; other site 1183438010086 phosphorylation site [posttranslational modification] 1183438010087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438010088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438010089 active site 1183438010090 phosphorylation site [posttranslational modification] 1183438010091 intermolecular recognition site; other site 1183438010092 dimerization interface [polypeptide binding]; other site 1183438010093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438010094 DNA binding site [nucleotide binding] 1183438010095 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1183438010096 plastocyanin; Provisional; Region: PRK02710 1183438010097 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1183438010098 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1183438010099 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1183438010100 Walker A/P-loop; other site 1183438010101 ATP binding site [chemical binding]; other site 1183438010102 Q-loop/lid; other site 1183438010103 ABC transporter signature motif; other site 1183438010104 Walker B; other site 1183438010105 D-loop; other site 1183438010106 H-loop/switch region; other site 1183438010107 hypothetical protein; Provisional; Region: PRK07208 1183438010108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438010109 UDP-galactopyranose mutase; Region: GLF; pfam03275 1183438010110 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 1183438010111 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1183438010112 putative valine binding site [chemical binding]; other site 1183438010113 dimer interface [polypeptide binding]; other site 1183438010114 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1183438010115 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1183438010116 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1183438010117 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1183438010118 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1183438010119 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1183438010120 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1183438010121 Peptidase family M23; Region: Peptidase_M23; pfam01551 1183438010122 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1183438010123 CsbD-like; Region: CsbD; pfam05532 1183438010124 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1183438010125 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1183438010126 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1183438010127 Walker A/P-loop; other site 1183438010128 ATP binding site [chemical binding]; other site 1183438010129 Q-loop/lid; other site 1183438010130 ABC transporter signature motif; other site 1183438010131 Walker B; other site 1183438010132 D-loop; other site 1183438010133 H-loop/switch region; other site 1183438010134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438010135 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1183438010136 Walker A/P-loop; other site 1183438010137 ATP binding site [chemical binding]; other site 1183438010138 Q-loop/lid; other site 1183438010139 ABC transporter signature motif; other site 1183438010140 Walker B; other site 1183438010141 D-loop; other site 1183438010142 H-loop/switch region; other site 1183438010143 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 1183438010144 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1183438010145 catalytic core [active] 1183438010146 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1183438010147 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438010148 active site 1183438010149 metal binding site [ion binding]; metal-binding site 1183438010150 hexamer interface [polypeptide binding]; other site 1183438010151 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1183438010152 interchain domain interface [polypeptide binding]; other site 1183438010153 heme bL binding site [chemical binding]; other site 1183438010154 intrachain domain interface; other site 1183438010155 heme bH binding site [chemical binding]; other site 1183438010156 Qo binding site; other site 1183438010157 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1183438010158 Qo binding site; other site 1183438010159 Protein of unknown function (DUF1637); Region: DUF1637; pfam07847 1183438010160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1183438010161 binding surface 1183438010162 TPR motif; other site 1183438010163 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1183438010164 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1183438010165 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1183438010166 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1183438010167 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1183438010168 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1183438010169 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010170 putative active site [active] 1183438010171 YD repeat-containing protein; fragment 1183438010172 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010173 putative active site [active] 1183438010174 HD domain; Region: HD_4; pfam13328 1183438010175 SnoaL-like domain; Region: SnoaL_4; pfam13577 1183438010176 SnoaL-like domain; Region: SnoaL_3; pfam13474 1183438010177 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1183438010178 Competence protein; Region: Competence; pfam03772 1183438010179 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1183438010180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438010181 dimer interface [polypeptide binding]; other site 1183438010182 phosphorylation site [posttranslational modification] 1183438010183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438010184 ATP binding site [chemical binding]; other site 1183438010185 Mg2+ binding site [ion binding]; other site 1183438010186 G-X-G motif; other site 1183438010187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438010188 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1183438010189 active site 1183438010190 phosphorylation site [posttranslational modification] 1183438010191 intermolecular recognition site; other site 1183438010192 dimerization interface [polypeptide binding]; other site 1183438010193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438010194 DNA binding site [nucleotide binding] 1183438010195 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438010196 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1183438010197 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438010198 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438010199 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010200 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010201 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438010202 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010203 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010204 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438010205 catalytic motif [active] 1183438010206 Catalytic residue [active] 1183438010207 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438010208 catalytic motif [active] 1183438010209 Catalytic residue [active] 1183438010210 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438010211 protein binding site [polypeptide binding]; other site 1183438010212 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1183438010213 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1183438010214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438010215 S-adenosylmethionine binding site [chemical binding]; other site 1183438010216 amidophosphoribosyltransferase; Provisional; Region: PRK07349 1183438010217 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1183438010218 active site 1183438010219 tetramer interface [polypeptide binding]; other site 1183438010220 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438010221 active site 1183438010222 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1183438010223 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1183438010224 dimerization interface [polypeptide binding]; other site 1183438010225 ATP binding site [chemical binding]; other site 1183438010226 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1183438010227 dimerization interface [polypeptide binding]; other site 1183438010228 ATP binding site [chemical binding]; other site 1183438010229 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 1183438010230 substrate binding site [chemical binding]; other site 1183438010231 putative active site [active] 1183438010232 redox center [active] 1183438010233 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1183438010234 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1183438010235 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1183438010236 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1183438010237 active site 1183438010238 DNA binding site [nucleotide binding] 1183438010239 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1183438010240 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1183438010241 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1183438010242 Catalytic site [active] 1183438010243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438010244 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1183438010245 Coenzyme A binding pocket [chemical binding]; other site 1183438010246 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1183438010247 TPP-binding site [chemical binding]; other site 1183438010248 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1183438010249 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1183438010250 PYR/PP interface [polypeptide binding]; other site 1183438010251 dimer interface [polypeptide binding]; other site 1183438010252 TPP binding site [chemical binding]; other site 1183438010253 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1183438010254 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1183438010255 SWIM zinc finger; Region: SWIM; pfam04434 1183438010256 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1183438010257 SNF2 Helicase protein; Region: DUF3670; pfam12419 1183438010258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438010259 ATP binding site [chemical binding]; other site 1183438010260 putative Mg++ binding site [ion binding]; other site 1183438010261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438010262 nucleotide binding region [chemical binding]; other site 1183438010263 ATP-binding site [chemical binding]; other site 1183438010264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438010265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438010266 active site 1183438010267 phosphorylation site [posttranslational modification] 1183438010268 intermolecular recognition site; other site 1183438010269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438010270 DNA binding residues [nucleotide binding] 1183438010271 dimerization interface [polypeptide binding]; other site 1183438010272 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1183438010273 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1183438010274 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1183438010275 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1183438010276 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1183438010277 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1183438010278 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1183438010279 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1183438010280 Walker A/P-loop; other site 1183438010281 ATP binding site [chemical binding]; other site 1183438010282 Q-loop/lid; other site 1183438010283 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1183438010284 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1183438010285 ABC transporter signature motif; other site 1183438010286 Walker B; other site 1183438010287 D-loop; other site 1183438010288 H-loop/switch region; other site 1183438010289 AAA-like domain; Region: AAA_10; pfam12846 1183438010290 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1183438010291 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 1183438010292 transposase IS4 family protein; frameshifted 1183438010293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1183438010294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1183438010295 non-specific DNA binding site [nucleotide binding]; other site 1183438010296 salt bridge; other site 1183438010297 sequence-specific DNA binding site [nucleotide binding]; other site 1183438010298 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 1183438010299 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1183438010300 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1183438010301 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1183438010302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1183438010303 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1183438010304 yybP-ykoY leader 1183438010305 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1183438010306 dimer interface [polypeptide binding]; other site 1183438010307 [2Fe-2S] cluster binding site [ion binding]; other site 1183438010308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438010309 TPR motif; other site 1183438010310 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438010311 binding surface 1183438010312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438010313 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1183438010314 Walker A motif; other site 1183438010315 ATP binding site [chemical binding]; other site 1183438010316 Walker B motif; other site 1183438010317 arginine finger; other site 1183438010318 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1183438010319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438010320 Walker A motif; other site 1183438010321 ATP binding site [chemical binding]; other site 1183438010322 Walker B motif; other site 1183438010323 arginine finger; other site 1183438010324 Peptidase family M41; Region: Peptidase_M41; pfam01434 1183438010325 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1183438010326 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1183438010327 dimerization interface [polypeptide binding]; other site 1183438010328 active site 1183438010329 metal binding site [ion binding]; metal-binding site 1183438010330 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1183438010331 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1183438010332 catalytic center binding site [active] 1183438010333 ATP binding site [chemical binding]; other site 1183438010334 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1183438010335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1183438010336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438010337 Coenzyme A binding pocket [chemical binding]; other site 1183438010338 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 1183438010339 phosphate binding site [ion binding]; other site 1183438010340 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1183438010341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438010342 S-adenosylmethionine binding site [chemical binding]; other site 1183438010343 Fic family protein [Function unknown]; Region: COG3177 1183438010344 Fic/DOC family; Region: Fic; pfam02661 1183438010345 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010346 putative active site [active] 1183438010347 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1183438010348 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1183438010349 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438010350 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438010351 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438010352 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438010353 Outer membrane efflux protein; Region: OEP; pfam02321 1183438010354 Outer membrane efflux protein; Region: OEP; pfam02321 1183438010355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438010356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438010357 active site 1183438010358 phosphorylation site [posttranslational modification] 1183438010359 intermolecular recognition site; other site 1183438010360 dimerization interface [polypeptide binding]; other site 1183438010361 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438010362 DNA binding site [nucleotide binding] 1183438010363 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438010364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438010365 dimerization interface [polypeptide binding]; other site 1183438010366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438010367 dimer interface [polypeptide binding]; other site 1183438010368 phosphorylation site [posttranslational modification] 1183438010369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438010370 ATP binding site [chemical binding]; other site 1183438010371 Mg2+ binding site [ion binding]; other site 1183438010372 G-X-G motif; other site 1183438010373 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 1183438010374 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1183438010375 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1183438010376 Walker A/P-loop; other site 1183438010377 ATP binding site [chemical binding]; other site 1183438010378 Q-loop/lid; other site 1183438010379 ABC transporter signature motif; other site 1183438010380 Walker B; other site 1183438010381 D-loop; other site 1183438010382 H-loop/switch region; other site 1183438010383 OstA-like protein; Region: OstA; cl00844 1183438010384 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1183438010385 dimer interface [polypeptide binding]; other site 1183438010386 active site 1183438010387 ADP-ribose binding site [chemical binding]; other site 1183438010388 nudix motif; other site 1183438010389 metal binding site [ion binding]; metal-binding site 1183438010390 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1183438010391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438010392 ATP binding site [chemical binding]; other site 1183438010393 Mg2+ binding site [ion binding]; other site 1183438010394 G-X-G motif; other site 1183438010395 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1183438010396 ATP binding site [chemical binding]; other site 1183438010397 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1183438010398 TIGR02646 family protein; Region: TIGR02646 1183438010399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438010400 AAA domain; Region: AAA_21; pfam13304 1183438010401 Walker A/P-loop; other site 1183438010402 ATP binding site [chemical binding]; other site 1183438010403 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1183438010404 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1183438010405 Walker A/P-loop; other site 1183438010406 ATP binding site [chemical binding]; other site 1183438010407 Q-loop/lid; other site 1183438010408 ABC transporter signature motif; other site 1183438010409 Walker B; other site 1183438010410 D-loop; other site 1183438010411 H-loop/switch region; other site 1183438010412 thymidylate kinase; Validated; Region: tmk; PRK00698 1183438010413 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1183438010414 TMP-binding site; other site 1183438010415 ATP-binding site [chemical binding]; other site 1183438010416 Predicted flavoprotein [General function prediction only]; Region: COG0431 1183438010417 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1183438010418 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1183438010419 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1183438010420 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1183438010421 putative heme binding pocket [chemical binding]; other site 1183438010422 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438010423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438010424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438010425 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438010426 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1183438010427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438010428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438010429 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1183438010430 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1183438010431 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1183438010432 Ligand binding site; other site 1183438010433 Putative Catalytic site; other site 1183438010434 DXD motif; other site 1183438010435 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1183438010436 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1183438010437 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1183438010438 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1183438010439 active site 1183438010440 homodimer interface [polypeptide binding]; other site 1183438010441 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1183438010442 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1183438010443 catalytic residue [active] 1183438010444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1183438010445 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1183438010446 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1183438010447 hypothetical protein; frameshifted 1183438010448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438010449 putative PBP binding loops; other site 1183438010450 ABC-ATPase subunit interface; other site 1183438010451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438010452 dimer interface [polypeptide binding]; other site 1183438010453 conserved gate region; other site 1183438010454 putative PBP binding loops; other site 1183438010455 ABC-ATPase subunit interface; other site 1183438010456 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1183438010457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438010458 dimer interface [polypeptide binding]; other site 1183438010459 conserved gate region; other site 1183438010460 putative PBP binding loops; other site 1183438010461 ABC-ATPase subunit interface; other site 1183438010462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1183438010463 active site 1183438010464 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 1183438010465 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1183438010466 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1183438010467 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1183438010468 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1183438010469 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1183438010470 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1183438010471 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1183438010472 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1183438010473 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1183438010474 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1183438010475 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1183438010476 DNA binding site [nucleotide binding] 1183438010477 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1183438010478 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1183438010479 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1183438010480 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1183438010481 active site 1183438010482 HIGH motif; other site 1183438010483 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1183438010484 KMSK motif region; other site 1183438010485 tRNA binding surface [nucleotide binding]; other site 1183438010486 DALR anticodon binding domain; Region: DALR_1; smart00836 1183438010487 anticodon binding site; other site 1183438010488 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1183438010489 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1183438010490 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1183438010491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438010492 Walker A/P-loop; other site 1183438010493 ATP binding site [chemical binding]; other site 1183438010494 Q-loop/lid; other site 1183438010495 ABC transporter signature motif; other site 1183438010496 Walker B; other site 1183438010497 D-loop; other site 1183438010498 H-loop/switch region; other site 1183438010499 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1183438010500 UbiA prenyltransferase family; Region: UbiA; pfam01040 1183438010501 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1183438010502 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1183438010503 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1183438010504 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1183438010505 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1183438010506 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1183438010507 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1183438010508 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1183438010509 Subunit I/III interface [polypeptide binding]; other site 1183438010510 CHAD domain; Region: CHAD; pfam05235 1183438010511 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1183438010512 PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041 1183438010513 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1183438010514 ATP-sulfurylase; Region: ATPS; cd00517 1183438010515 active site 1183438010516 HXXH motif; other site 1183438010517 flexible loop; other site 1183438010518 amidase; Provisional; Region: PRK06828 1183438010519 Amidase; Region: Amidase; cl11426 1183438010520 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 1183438010521 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1183438010522 active site 1183438010523 DNA binding site [nucleotide binding] 1183438010524 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1183438010525 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1183438010526 motif 1; other site 1183438010527 active site 1183438010528 motif 2; other site 1183438010529 motif 3; other site 1183438010530 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1183438010531 amino acid transporter; Region: 2A0306; TIGR00909 1183438010532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438010533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438010534 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1183438010535 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1183438010536 FMN binding site [chemical binding]; other site 1183438010537 active site 1183438010538 substrate binding site [chemical binding]; other site 1183438010539 catalytic residue [active] 1183438010540 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1183438010541 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1183438010542 dimer interface [polypeptide binding]; other site 1183438010543 active site 1183438010544 metal binding site [ion binding]; metal-binding site 1183438010545 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1183438010546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1183438010547 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1183438010548 Electron transfer DM13; Region: DM13; pfam10517 1183438010549 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010550 putative active site [active] 1183438010551 tellurium resistance terB-like protein; Region: terB_like; cl11965 1183438010552 metal binding site [ion binding]; metal-binding site 1183438010553 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010554 putative active site [active] 1183438010555 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1183438010556 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1183438010557 Walker A/P-loop; other site 1183438010558 ATP binding site [chemical binding]; other site 1183438010559 Q-loop/lid; other site 1183438010560 ABC transporter signature motif; other site 1183438010561 Walker B; other site 1183438010562 D-loop; other site 1183438010563 H-loop/switch region; other site 1183438010564 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1183438010565 PDGLE domain; Region: PDGLE; cl07986 1183438010566 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 1183438010567 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1183438010568 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438010569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010570 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010571 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438010572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010573 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438010574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010576 TIR domain; Region: TIR_2; pfam13676 1183438010577 BioY family; Region: BioY; pfam02632 1183438010578 Protein of unknown function (DUF751); Region: DUF751; pfam05421 1183438010579 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1183438010580 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1183438010581 AAA domain; Region: AAA_26; pfam13500 1183438010582 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1183438010583 trimer interface [polypeptide binding]; other site 1183438010584 active site 1183438010585 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1183438010586 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1183438010587 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1183438010588 HSP70 interaction site [polypeptide binding]; other site 1183438010589 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 1183438010590 Galactose-3-O-sulfotransferase; Region: Gal-3-0_sulfotr; pfam06990 1183438010591 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1183438010592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1183438010593 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1183438010594 Probable transposase; Region: OrfB_IS605; pfam01385 1183438010595 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1183438010596 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1183438010597 transposase; truncated 1183438010598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438010599 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1183438010600 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1183438010601 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1183438010602 active site 1183438010603 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1183438010604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1183438010605 Amidohydrolase; Region: Amidohydro_5; pfam13594 1183438010606 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1183438010607 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1183438010608 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1183438010609 active site 1183438010610 putative lipid kinase; Reviewed; Region: PRK00861 1183438010611 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1183438010612 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 1183438010613 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 1183438010614 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 1183438010615 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 1183438010616 P-loop; other site 1183438010617 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 1183438010618 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1183438010619 NADH dehydrogenase subunit 7; Region: ndhH; CHL00017 1183438010620 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1183438010621 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1183438010622 putative di-iron ligands [ion binding]; other site 1183438010623 dihydroorotase; Provisional; Region: PRK07369 1183438010624 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1183438010625 active site 1183438010626 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1183438010627 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1183438010628 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1183438010629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438010630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438010631 DNA binding residues [nucleotide binding] 1183438010632 dimerization interface [polypeptide binding]; other site 1183438010633 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 1183438010634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438010635 DNA binding residues [nucleotide binding] 1183438010636 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1183438010637 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1183438010638 peptide binding site [polypeptide binding]; other site 1183438010639 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1183438010640 PIN domain; Region: PIN_3; cl17397 1183438010641 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1183438010642 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1183438010643 ring oligomerisation interface [polypeptide binding]; other site 1183438010644 ATP/Mg binding site [chemical binding]; other site 1183438010645 stacking interactions; other site 1183438010646 hinge regions; other site 1183438010647 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1183438010648 oligomerisation interface [polypeptide binding]; other site 1183438010649 mobile loop; other site 1183438010650 roof hairpin; other site 1183438010651 lipoyl synthase; Provisional; Region: PRK05481 1183438010652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438010653 FeS/SAM binding site; other site 1183438010654 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1183438010655 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1183438010656 putative active site [active] 1183438010657 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010658 putative active site [active] 1183438010659 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1183438010660 MutS domain I; Region: MutS_I; pfam01624 1183438010661 MutS domain II; Region: MutS_II; pfam05188 1183438010662 MutS domain III; Region: MutS_III; pfam05192 1183438010663 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1183438010664 Walker A/P-loop; other site 1183438010665 ATP binding site [chemical binding]; other site 1183438010666 Q-loop/lid; other site 1183438010667 ABC transporter signature motif; other site 1183438010668 Walker B; other site 1183438010669 D-loop; other site 1183438010670 H-loop/switch region; other site 1183438010671 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1183438010672 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1183438010673 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1183438010674 hinge; other site 1183438010675 active site 1183438010676 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 1183438010677 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1183438010678 triosephosphate isomerase; Provisional; Region: PRK14565 1183438010679 substrate binding site [chemical binding]; other site 1183438010680 dimer interface [polypeptide binding]; other site 1183438010681 catalytic triad [active] 1183438010682 Psb28 protein; Region: Psb28; cl04326 1183438010683 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1183438010684 homopentamer interface [polypeptide binding]; other site 1183438010685 active site 1183438010686 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 1183438010687 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1183438010688 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1183438010689 FMN binding site [chemical binding]; other site 1183438010690 active site 1183438010691 catalytic residues [active] 1183438010692 substrate binding site [chemical binding]; other site 1183438010693 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1183438010694 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1183438010695 nudix motif; other site 1183438010696 Psb28 protein; Region: Psb28; cl04326 1183438010697 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1183438010698 nucleotide binding site/active site [active] 1183438010699 HIT family signature motif; other site 1183438010700 catalytic residue [active] 1183438010701 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1183438010702 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1183438010703 Predicted permeases [General function prediction only]; Region: COG0795 1183438010704 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1183438010705 glycogen synthase; Provisional; Region: glgA; PRK00654 1183438010706 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1183438010707 ADP-binding pocket [chemical binding]; other site 1183438010708 homodimer interface [polypeptide binding]; other site 1183438010709 Ion channel; Region: Ion_trans_2; pfam07885 1183438010710 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1183438010711 TrkA-N domain; Region: TrkA_N; pfam02254 1183438010712 TrkA-C domain; Region: TrkA_C; pfam02080 1183438010713 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1183438010714 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1183438010715 active site 1183438010716 dimer interface [polypeptide binding]; other site 1183438010717 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1183438010718 4Fe-4S binding domain; Region: Fer4; pfam00037 1183438010719 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1183438010720 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438010721 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1183438010722 putative ADP-binding pocket [chemical binding]; other site 1183438010723 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1183438010724 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1183438010725 putative NAD(P) binding site [chemical binding]; other site 1183438010726 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1183438010727 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1183438010728 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1183438010729 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1183438010730 dimer interface [polypeptide binding]; other site 1183438010731 active site 1183438010732 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 1183438010733 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1183438010734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438010735 FeS/SAM binding site; other site 1183438010736 TRAM domain; Region: TRAM; pfam01938 1183438010737 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1183438010738 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1183438010739 active site 1183438010740 (T/H)XGH motif; other site 1183438010741 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1183438010742 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1183438010743 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1183438010744 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1183438010745 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1183438010746 active site 1183438010747 Substrate binding site; other site 1183438010748 Mg++ binding site; other site 1183438010749 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1183438010750 putative trimer interface [polypeptide binding]; other site 1183438010751 putative CoA binding site [chemical binding]; other site 1183438010752 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1183438010753 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1183438010754 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1183438010755 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1183438010756 O-Antigen ligase; Region: Wzy_C; cl04850 1183438010757 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438010758 active site 1183438010759 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1183438010760 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1183438010761 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1183438010762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1183438010763 active site 1183438010764 BNR repeat-like domain; Region: BNR_2; pfam13088 1183438010765 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010766 putative active site [active] 1183438010767 Predicted membrane protein [Function unknown]; Region: COG3431 1183438010768 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1183438010769 Fasciclin domain; Region: Fasciclin; pfam02469 1183438010770 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 1183438010771 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 1183438010772 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438010773 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1183438010774 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438010775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1183438010776 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1183438010777 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1183438010778 putative dimerization interface [polypeptide binding]; other site 1183438010779 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438010780 Ligand Binding Site [chemical binding]; other site 1183438010781 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1183438010782 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1183438010783 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1183438010784 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1183438010785 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1183438010786 EamA-like transporter family; Region: EamA; pfam00892 1183438010787 EamA-like transporter family; Region: EamA; pfam00892 1183438010788 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438010789 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010790 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438010791 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1183438010792 Family of unknown function (DUF490); Region: DUF490; pfam04357 1183438010793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 1183438010794 conserved hypothetical protein; Region: TIGR03492 1183438010795 L-asparaginase II; Region: Asparaginase_II; pfam06089 1183438010796 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 1183438010797 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1183438010798 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1183438010799 active site 1183438010800 nucleotide binding site [chemical binding]; other site 1183438010801 HIGH motif; other site 1183438010802 KMSKS motif; other site 1183438010803 L-aspartate oxidase; Provisional; Region: PRK07395 1183438010804 L-aspartate oxidase; Provisional; Region: PRK06175 1183438010805 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1183438010806 photosystem I subunit VII; Region: psaC; CHL00065 1183438010807 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1183438010808 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1183438010809 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1183438010810 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1183438010811 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1183438010812 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1183438010813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438010814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438010815 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1183438010816 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1183438010817 putative switch regulator; other site 1183438010818 non-specific DNA interactions [nucleotide binding]; other site 1183438010819 DNA binding site [nucleotide binding] 1183438010820 sequence specific DNA binding site [nucleotide binding]; other site 1183438010821 putative cAMP binding site [chemical binding]; other site 1183438010822 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1183438010823 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1183438010824 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438010825 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438010826 FtsX-like permease family; Region: FtsX; pfam02687 1183438010827 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1183438010828 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 1183438010829 active site residue [active] 1183438010830 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1183438010831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1183438010832 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1183438010833 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1183438010834 active site 1183438010835 substrate binding site [chemical binding]; other site 1183438010836 catalytic site [active] 1183438010837 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1183438010838 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1183438010839 molybdopterin cofactor binding site; other site 1183438010840 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 1183438010841 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438010842 putative active site [active] 1183438010843 putative catalytic triad [active] 1183438010844 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1183438010845 catalytic residues [active] 1183438010846 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1183438010847 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1183438010848 NADP binding site [chemical binding]; other site 1183438010849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438010850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438010851 WHG domain; Region: WHG; pfam13305 1183438010852 PRC-barrel domain; Region: PRC; pfam05239 1183438010853 PRC-barrel domain; Region: PRC; pfam05239 1183438010854 hypothetical protein; Provisional; Region: PRK04194 1183438010855 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1183438010856 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 1183438010857 acetylornithine aminotransferase; Provisional; Region: PRK02627 1183438010858 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1183438010859 inhibitor-cofactor binding pocket; inhibition site 1183438010860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438010861 catalytic residue [active] 1183438010862 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1183438010863 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1183438010864 CRISPR-associated protein; Region: DUF3692; pfam12469 1183438010865 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 1183438010866 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 1183438010867 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 1183438010868 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 1183438010869 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1183438010870 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 1183438010871 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1183438010872 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1183438010873 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 1183438010874 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1183438010875 hypothetical protein; fragment 1183438010876 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010877 putative active site [active] 1183438010878 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1183438010879 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1183438010880 active site 1183438010881 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010882 putative active site [active] 1183438010883 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1183438010884 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1183438010885 Ligand Binding Site [chemical binding]; other site 1183438010886 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1183438010887 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1183438010888 B12 binding site [chemical binding]; other site 1183438010889 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1183438010890 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1183438010891 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1183438010892 phosphoglucomutase; Region: PLN02307 1183438010893 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1183438010894 substrate binding site [chemical binding]; other site 1183438010895 dimer interface [polypeptide binding]; other site 1183438010896 active site 1183438010897 metal binding site [ion binding]; metal-binding site 1183438010898 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1183438010899 catalytic core [active] 1183438010900 Septum formation topological specificity factor MinE; Region: MinE; cl00538 1183438010901 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1183438010902 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1183438010903 P-loop; other site 1183438010904 ADP binding residues [chemical binding]; other site 1183438010905 Switch I; other site 1183438010906 Switch II; other site 1183438010907 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1183438010908 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1183438010909 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1183438010910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438010911 S-adenosylmethionine binding site [chemical binding]; other site 1183438010912 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1183438010913 C-terminal peptidase (prc); Region: prc; TIGR00225 1183438010914 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1183438010915 active site triad [active] 1183438010916 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438010917 putative active site [active] 1183438010918 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1183438010919 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1183438010920 GTP/Mg2+ binding site [chemical binding]; other site 1183438010921 G4 box; other site 1183438010922 G5 box; other site 1183438010923 G1 box; other site 1183438010924 Switch I region; other site 1183438010925 G2 box; other site 1183438010926 G3 box; other site 1183438010927 Switch II region; other site 1183438010928 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1183438010929 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1183438010930 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1183438010931 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1183438010932 active site 1183438010933 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1183438010934 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1183438010935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438010936 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1183438010937 Amidohydrolase; Region: Amidohydro_5; pfam13594 1183438010938 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1183438010939 active site 1183438010940 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1183438010941 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1183438010942 HIGH motif; other site 1183438010943 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1183438010944 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1183438010945 active site 1183438010946 KMSKS motif; other site 1183438010947 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1183438010948 tRNA binding surface [nucleotide binding]; other site 1183438010949 anticodon binding site; other site 1183438010950 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1183438010951 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1183438010952 CGNR zinc finger; Region: zf-CGNR; pfam11706 1183438010953 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438010954 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1183438010955 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1183438010956 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1183438010957 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1183438010958 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1183438010959 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1183438010960 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1183438010961 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1183438010962 metal binding site [ion binding]; metal-binding site 1183438010963 dimer interface [polypeptide binding]; other site 1183438010964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 1183438010965 conserved hypothetical protein; Region: TIGR03492 1183438010966 H+ Antiporter protein; Region: 2A0121; TIGR00900 1183438010967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438010968 putative substrate translocation pore; other site 1183438010969 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 1183438010970 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438010971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438010972 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1183438010973 active site 1183438010974 catalytic tetrad [active] 1183438010975 short chain dehydrogenase; Provisional; Region: PRK06172 1183438010976 classical (c) SDRs; Region: SDR_c; cd05233 1183438010977 NAD(P) binding site [chemical binding]; other site 1183438010978 active site 1183438010979 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1183438010980 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1183438010981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438010982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1183438010983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438010984 S-adenosylmethionine binding site [chemical binding]; other site 1183438010985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1183438010986 dimerization interface [polypeptide binding]; other site 1183438010987 putative DNA binding site [nucleotide binding]; other site 1183438010988 putative Zn2+ binding site [ion binding]; other site 1183438010989 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 1183438010990 putative hydrophobic ligand binding site [chemical binding]; other site 1183438010991 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1183438010992 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1183438010993 putative active site [active] 1183438010994 metal binding site [ion binding]; metal-binding site 1183438010995 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1183438010996 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1183438010997 C-terminal domain interface [polypeptide binding]; other site 1183438010998 GSH binding site (G-site) [chemical binding]; other site 1183438010999 dimer interface [polypeptide binding]; other site 1183438011000 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1183438011001 N-terminal domain interface [polypeptide binding]; other site 1183438011002 putative dimer interface [polypeptide binding]; other site 1183438011003 active site 1183438011004 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1183438011005 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1183438011006 S-layer homology domain; Region: SLH; pfam00395 1183438011007 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1183438011008 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1183438011009 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1183438011010 putative ADP-binding pocket [chemical binding]; other site 1183438011011 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1183438011012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438011013 active site 1183438011014 motif I; other site 1183438011015 motif II; other site 1183438011016 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 1183438011017 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1183438011018 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1183438011019 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1183438011020 active site 1183438011021 substrate binding site [chemical binding]; other site 1183438011022 Mg2+ binding site [ion binding]; other site 1183438011023 Predicted transcriptional regulator [Transcription]; Region: COG3905 1183438011024 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1183438011025 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1183438011026 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1183438011027 active site 1183438011028 Zn binding site [ion binding]; other site 1183438011029 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438011030 catalytic motif [active] 1183438011031 Catalytic residue [active] 1183438011032 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1183438011033 catalytic motif [active] 1183438011034 Catalytic residue [active] 1183438011035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438011036 binding surface 1183438011037 TPR motif; other site 1183438011038 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1183438011039 hydrolase, alpha/beta fold family protein; Region: PLN02824 1183438011040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1183438011041 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1183438011042 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1183438011043 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1183438011044 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1183438011045 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1183438011046 dimer interface [polypeptide binding]; other site 1183438011047 active site 1183438011048 catalytic residue [active] 1183438011049 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1183438011050 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1183438011051 CHASE3 domain; Region: CHASE3; pfam05227 1183438011052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438011053 dimerization interface [polypeptide binding]; other site 1183438011054 GAF domain; Region: GAF_3; pfam13492 1183438011055 GAF domain; Region: GAF_2; pfam13185 1183438011056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438011057 PAS domain; Region: PAS_9; pfam13426 1183438011058 putative active site [active] 1183438011059 heme pocket [chemical binding]; other site 1183438011060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1183438011061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438011062 dimer interface [polypeptide binding]; other site 1183438011063 phosphorylation site [posttranslational modification] 1183438011064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438011065 ATP binding site [chemical binding]; other site 1183438011066 Mg2+ binding site [ion binding]; other site 1183438011067 G-X-G motif; other site 1183438011068 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438011069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438011070 active site 1183438011071 phosphorylation site [posttranslational modification] 1183438011072 intermolecular recognition site; other site 1183438011073 dimerization interface [polypeptide binding]; other site 1183438011074 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1183438011075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438011076 active site 1183438011077 phosphorylation site [posttranslational modification] 1183438011078 intermolecular recognition site; other site 1183438011079 dimerization interface [polypeptide binding]; other site 1183438011080 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1183438011081 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1183438011082 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1183438011083 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 1183438011084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438011085 FeS/SAM binding site; other site 1183438011086 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 1183438011087 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 1183438011088 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1183438011089 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1183438011090 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1183438011091 Strictosidine synthase; Region: Str_synth; pfam03088 1183438011092 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1183438011093 DALR anticodon binding domain; Region: DALR_1; smart00836 1183438011094 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1183438011095 catalytic loop [active] 1183438011096 iron binding site [ion binding]; other site 1183438011097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438011098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438011099 active site 1183438011100 phosphorylation site [posttranslational modification] 1183438011101 intermolecular recognition site; other site 1183438011102 dimerization interface [polypeptide binding]; other site 1183438011103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438011104 DNA binding site [nucleotide binding] 1183438011105 Ycf46; Provisional; Region: ycf46; CHL00195 1183438011106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438011107 Walker A motif; other site 1183438011108 ATP binding site [chemical binding]; other site 1183438011109 Walker B motif; other site 1183438011110 arginine finger; other site 1183438011111 TPR repeat; Region: TPR_11; pfam13414 1183438011112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438011113 binding surface 1183438011114 TPR motif; other site 1183438011115 TPR repeat; Region: TPR_11; pfam13414 1183438011116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438011117 binding surface 1183438011118 TPR motif; other site 1183438011119 TPR repeat; Region: TPR_11; pfam13414 1183438011120 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1183438011121 homotrimer interaction site [polypeptide binding]; other site 1183438011122 putative active site [active] 1183438011123 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1183438011124 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1183438011125 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1183438011126 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1183438011127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1183438011128 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438011129 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1183438011130 active site 1183438011131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438011132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438011133 intermolecular recognition site; other site 1183438011134 active site 1183438011135 dimerization interface [polypeptide binding]; other site 1183438011136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438011137 DNA binding site [nucleotide binding] 1183438011138 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1183438011139 putative switch regulator; other site 1183438011140 non-specific DNA interactions [nucleotide binding]; other site 1183438011141 DNA binding site [nucleotide binding] 1183438011142 sequence specific DNA binding site [nucleotide binding]; other site 1183438011143 putative cAMP binding site [chemical binding]; other site 1183438011144 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1183438011145 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 1183438011146 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 1183438011147 active site 1183438011148 catalytic site [active] 1183438011149 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1183438011150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438011151 dimer interface [polypeptide binding]; other site 1183438011152 conserved gate region; other site 1183438011153 putative PBP binding loops; other site 1183438011154 ABC-ATPase subunit interface; other site 1183438011155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438011156 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1183438011157 Walker A/P-loop; other site 1183438011158 ATP binding site [chemical binding]; other site 1183438011159 Q-loop/lid; other site 1183438011160 ABC transporter signature motif; other site 1183438011161 Walker B; other site 1183438011162 D-loop; other site 1183438011163 H-loop/switch region; other site 1183438011164 sulfite oxidase; Provisional; Region: PLN00177 1183438011165 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1183438011166 Moco binding site; other site 1183438011167 metal coordination site [ion binding]; other site 1183438011168 dimerization interface [polypeptide binding]; other site 1183438011169 PBP superfamily domain; Region: PBP_like_2; pfam12849 1183438011170 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1183438011171 HAMP domain; Region: HAMP; pfam00672 1183438011172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438011173 binding surface 1183438011174 TPR motif; other site 1183438011175 TPR repeat; Region: TPR_11; pfam13414 1183438011176 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1183438011177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1183438011178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1183438011179 ABC transporter; Region: ABC_tran_2; pfam12848 1183438011180 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1183438011181 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1183438011182 hypothetical protein; Reviewed; Region: PRK09588 1183438011183 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1183438011184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1183438011185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1183438011186 Coenzyme A binding pocket [chemical binding]; other site 1183438011187 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1183438011188 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1183438011189 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1183438011190 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1183438011191 RNB domain; Region: RNB; pfam00773 1183438011192 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1183438011193 RNA binding site [nucleotide binding]; other site 1183438011194 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1183438011195 LabA_like proteins; Region: LabA; cd10911 1183438011196 putative metal binding site [ion binding]; other site 1183438011197 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1183438011198 dimer interface [polypeptide binding]; other site 1183438011199 motif 1; other site 1183438011200 active site 1183438011201 motif 2; other site 1183438011202 motif 3; other site 1183438011203 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1183438011204 light-harvesting-like protein 3; Provisional; Region: PLN00014 1183438011205 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1183438011206 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1183438011207 GIY-YIG motif/motif A; other site 1183438011208 active site 1183438011209 catalytic site [active] 1183438011210 putative DNA binding site [nucleotide binding]; other site 1183438011211 metal binding site [ion binding]; metal-binding site 1183438011212 UvrB/uvrC motif; Region: UVR; pfam02151 1183438011213 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1183438011214 PsbP; Region: PsbP; cl03356 1183438011215 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1183438011216 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1183438011217 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1183438011218 Walker A/P-loop; other site 1183438011219 ATP binding site [chemical binding]; other site 1183438011220 Q-loop/lid; other site 1183438011221 ABC transporter signature motif; other site 1183438011222 Walker B; other site 1183438011223 D-loop; other site 1183438011224 H-loop/switch region; other site 1183438011225 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1183438011226 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1183438011227 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1183438011228 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1183438011229 dimer interface [polypeptide binding]; other site 1183438011230 putative metal binding site [ion binding]; other site 1183438011231 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1183438011232 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1183438011233 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438011234 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438011235 FtsX-like permease family; Region: FtsX; pfam02687 1183438011236 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1183438011237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438011238 Walker A motif; other site 1183438011239 ATP binding site [chemical binding]; other site 1183438011240 Walker B motif; other site 1183438011241 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1183438011242 MarR family; Region: MarR; pfam01047 1183438011243 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438011244 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438011245 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438011246 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1183438011247 Protein export membrane protein; Region: SecD_SecF; cl14618 1183438011248 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1183438011249 16S/18S rRNA binding site [nucleotide binding]; other site 1183438011250 S13e-L30e interaction site [polypeptide binding]; other site 1183438011251 25S rRNA binding site [nucleotide binding]; other site 1183438011252 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 1183438011253 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1183438011254 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1183438011255 dimer interface [polypeptide binding]; other site 1183438011256 motif 1; other site 1183438011257 motif 2; other site 1183438011258 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1183438011259 active site 1183438011260 motif 3; other site 1183438011261 Predicted dehydrogenase [General function prediction only]; Region: COG5322 1183438011262 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1183438011263 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1183438011264 [4Fe-4S] binding site [ion binding]; other site 1183438011265 molybdopterin cofactor binding site; other site 1183438011266 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1183438011267 molybdopterin cofactor binding site; other site 1183438011268 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1183438011269 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1183438011270 Walker A/P-loop; other site 1183438011271 ATP binding site [chemical binding]; other site 1183438011272 Q-loop/lid; other site 1183438011273 ABC transporter signature motif; other site 1183438011274 Walker B; other site 1183438011275 D-loop; other site 1183438011276 H-loop/switch region; other site 1183438011277 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1183438011278 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1183438011279 Walker A/P-loop; other site 1183438011280 ATP binding site [chemical binding]; other site 1183438011281 Q-loop/lid; other site 1183438011282 ABC transporter signature motif; other site 1183438011283 Walker B; other site 1183438011284 D-loop; other site 1183438011285 H-loop/switch region; other site 1183438011286 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1183438011287 NMT1-like family; Region: NMT1_2; pfam13379 1183438011288 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1183438011289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438011290 dimer interface [polypeptide binding]; other site 1183438011291 conserved gate region; other site 1183438011292 putative PBP binding loops; other site 1183438011293 ABC-ATPase subunit interface; other site 1183438011294 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1183438011295 NMT1-like family; Region: NMT1_2; pfam13379 1183438011296 PIN domain; Region: PIN_3; pfam13470 1183438011297 Helix-turn-helix domain; Region: HTH_17; cl17695 1183438011298 Yqey-like protein; Region: YqeY; cl17540 1183438011299 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1183438011300 RNA binding surface [nucleotide binding]; other site 1183438011301 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1183438011302 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1183438011303 G1 box; other site 1183438011304 putative GEF interaction site [polypeptide binding]; other site 1183438011305 GTP/Mg2+ binding site [chemical binding]; other site 1183438011306 Switch I region; other site 1183438011307 G2 box; other site 1183438011308 G3 box; other site 1183438011309 Switch II region; other site 1183438011310 G4 box; other site 1183438011311 G5 box; other site 1183438011312 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1183438011313 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1183438011314 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1183438011315 dimer interface [polypeptide binding]; other site 1183438011316 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1183438011317 catalytic triad [active] 1183438011318 peroxidatic and resolving cysteines [active] 1183438011319 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1183438011320 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438011321 catalytic residues [active] 1183438011322 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 1183438011323 putative hexamer interface [polypeptide binding]; other site 1183438011324 putative hexagonal pore; other site 1183438011325 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1183438011326 Hexamer interface [polypeptide binding]; other site 1183438011327 Hexagonal pore residue; other site 1183438011328 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1183438011329 Maf-like protein; Region: Maf; pfam02545 1183438011330 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1183438011331 active site 1183438011332 dimer interface [polypeptide binding]; other site 1183438011333 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1183438011334 NMT1-like family; Region: NMT1_2; pfam13379 1183438011335 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1183438011336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438011337 dimer interface [polypeptide binding]; other site 1183438011338 conserved gate region; other site 1183438011339 putative PBP binding loops; other site 1183438011340 ABC-ATPase subunit interface; other site 1183438011341 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1183438011342 active site clefts [active] 1183438011343 zinc binding site [ion binding]; other site 1183438011344 dimer interface [polypeptide binding]; other site 1183438011345 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1183438011346 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1183438011347 Walker A/P-loop; other site 1183438011348 ATP binding site [chemical binding]; other site 1183438011349 Q-loop/lid; other site 1183438011350 ABC transporter signature motif; other site 1183438011351 Walker B; other site 1183438011352 D-loop; other site 1183438011353 H-loop/switch region; other site 1183438011354 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1183438011355 NMT1-like family; Region: NMT1_2; pfam13379 1183438011356 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1183438011357 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1183438011358 Walker A/P-loop; other site 1183438011359 ATP binding site [chemical binding]; other site 1183438011360 Q-loop/lid; other site 1183438011361 ABC transporter signature motif; other site 1183438011362 Walker B; other site 1183438011363 D-loop; other site 1183438011364 H-loop/switch region; other site 1183438011365 transposase; fragment 1183438011366 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1183438011367 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1183438011368 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1183438011369 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1183438011370 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1183438011371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1183438011372 HNH endonuclease; frameshifted 1183438011373 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 1183438011374 glutamate formiminotransferase; Region: FtcD; TIGR02024 1183438011375 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 1183438011376 Formiminotransferase domain; Region: FTCD; pfam02971 1183438011377 imidazolonepropionase; Validated; Region: PRK09356 1183438011378 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1183438011379 active site 1183438011380 urocanate hydratase; Provisional; Region: PRK05414 1183438011381 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1183438011382 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438011383 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1183438011384 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1183438011385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438011386 S-adenosylmethionine binding site [chemical binding]; other site 1183438011387 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1183438011388 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1183438011389 Probable Catalytic site; other site 1183438011390 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1183438011391 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1183438011392 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1183438011393 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438011394 threonine synthase; Validated; Region: PRK08197 1183438011395 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1183438011396 homodimer interface [polypeptide binding]; other site 1183438011397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438011398 catalytic residue [active] 1183438011399 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1183438011400 KWG Leptospira; Region: KWG; pfam07656 1183438011401 KWG Leptospira; Region: KWG; pfam07656 1183438011402 KWG Leptospira; Region: KWG; pfam07656 1183438011403 KWG Leptospira; Region: KWG; pfam07656 1183438011404 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1183438011405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1183438011406 NAD(P) binding site [chemical binding]; other site 1183438011407 active site 1183438011408 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1183438011409 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1183438011410 active site 1183438011411 dimer interface [polypeptide binding]; other site 1183438011412 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1183438011413 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1183438011414 substrate binding site [chemical binding]; other site 1183438011415 hexamer interface [polypeptide binding]; other site 1183438011416 metal binding site [ion binding]; metal-binding site 1183438011417 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1183438011418 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1183438011419 putative active site [active] 1183438011420 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1183438011421 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1183438011422 putative active site; other site 1183438011423 catalytic residue [active] 1183438011424 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1183438011425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438011426 active site 1183438011427 motif I; other site 1183438011428 motif II; other site 1183438011429 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1183438011430 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1183438011431 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1183438011432 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1183438011433 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1183438011434 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1183438011435 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 1183438011436 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1183438011437 putative active site [active] 1183438011438 catalytic residue [active] 1183438011439 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1183438011440 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1183438011441 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 1183438011442 Domain interface; other site 1183438011443 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 1183438011444 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1183438011445 GTP-binding protein LepA; Provisional; Region: PRK05433 1183438011446 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1183438011447 G1 box; other site 1183438011448 putative GEF interaction site [polypeptide binding]; other site 1183438011449 GTP/Mg2+ binding site [chemical binding]; other site 1183438011450 Switch I region; other site 1183438011451 G2 box; other site 1183438011452 G3 box; other site 1183438011453 Switch II region; other site 1183438011454 G4 box; other site 1183438011455 G5 box; other site 1183438011456 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1183438011457 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1183438011458 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1183438011459 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1183438011460 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1183438011461 Walker A/P-loop; other site 1183438011462 ATP binding site [chemical binding]; other site 1183438011463 Q-loop/lid; other site 1183438011464 ABC transporter signature motif; other site 1183438011465 Walker B; other site 1183438011466 D-loop; other site 1183438011467 H-loop/switch region; other site 1183438011468 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438011469 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438011470 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438011471 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438011472 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438011473 hypothetical protein; frameshifted 1183438011474 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438011475 putative active site [active] 1183438011476 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1183438011477 TAP-like protein; Region: Abhydrolase_4; pfam08386 1183438011478 DNA polymerase III subunit delta'; Validated; Region: PRK07399 1183438011479 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1183438011480 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1183438011481 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1183438011482 glycogen binding site [chemical binding]; other site 1183438011483 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 1183438011484 active site 1183438011485 catalytic site [active] 1183438011486 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1183438011487 adenosine deaminase; Provisional; Region: PRK09358 1183438011488 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1183438011489 active site 1183438011490 ChaB; Region: ChaB; pfam06150 1183438011491 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438011492 TAP-like protein; Region: Abhydrolase_4; pfam08386 1183438011493 hypothetical protein; Provisional; Region: PRK02237 1183438011494 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1183438011495 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1183438011496 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1183438011497 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 1183438011498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1183438011499 FeS/SAM binding site; other site 1183438011500 Protein of unknown function (DUF512); Region: DUF512; pfam04459 1183438011501 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1183438011502 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1183438011503 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1183438011504 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1183438011505 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1183438011506 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1183438011507 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1183438011508 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1183438011509 Cytochrome c; Region: Cytochrom_C; pfam00034 1183438011510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1183438011511 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1183438011512 substrate binding pocket [chemical binding]; other site 1183438011513 membrane-bound complex binding site; other site 1183438011514 hinge residues; other site 1183438011515 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1183438011516 23S rRNA binding site [nucleotide binding]; other site 1183438011517 L21 binding site [polypeptide binding]; other site 1183438011518 L13 binding site [polypeptide binding]; other site 1183438011519 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1183438011520 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1183438011521 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 1183438011522 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1183438011523 NAD binding site [chemical binding]; other site 1183438011524 homotetramer interface [polypeptide binding]; other site 1183438011525 homodimer interface [polypeptide binding]; other site 1183438011526 active site 1183438011527 substrate binding site [chemical binding]; other site 1183438011528 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1183438011529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438011530 S-adenosylmethionine binding site [chemical binding]; other site 1183438011531 Phycobilisome protein; Region: Phycobilisome; pfam00502 1183438011532 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1183438011533 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438011534 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438011535 HEAT repeats; Region: HEAT_2; pfam13646 1183438011536 HEAT repeats; Region: HEAT_2; pfam13646 1183438011537 HEAT repeats; Region: HEAT_2; pfam13646 1183438011538 HEAT repeats; Region: HEAT_2; pfam13646 1183438011539 HEAT repeats; Region: HEAT_2; pfam13646 1183438011540 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438011541 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438011542 CpeS-like protein; Region: CpeS; pfam09367 1183438011543 CpeS-like protein; Region: CpeS; pfam09367 1183438011544 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1183438011545 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438011546 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1183438011547 HEAT repeats; Region: HEAT_2; pfam13646 1183438011548 HEAT repeats; Region: HEAT_2; pfam13646 1183438011549 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438011550 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438011551 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438011552 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438011553 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1183438011554 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438011555 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1183438011556 CpeS-like protein; Region: CpeS; pfam09367 1183438011557 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 1183438011558 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 1183438011559 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438011560 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438011561 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438011562 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438011563 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438011564 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 1183438011565 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1183438011566 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 1183438011567 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1183438011568 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1183438011569 HEAT repeats; Region: HEAT_2; pfam13646 1183438011570 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1183438011571 HEAT repeats; Region: HEAT_2; pfam13646 1183438011572 HEAT repeats; Region: HEAT_2; pfam13646 1183438011573 HEAT repeats; Region: HEAT_2; pfam13646 1183438011574 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1183438011575 Protein phosphatase 2C; Region: PP2C; pfam00481 1183438011576 active site 1183438011577 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1183438011578 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1183438011579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1183438011580 catalytic residue [active] 1183438011581 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1183438011582 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1183438011583 MarR family; Region: MarR_2; cl17246 1183438011584 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1183438011585 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1183438011586 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1183438011587 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1183438011588 MltA specific insert domain; Region: MltA; pfam03562 1183438011589 3D domain; Region: 3D; pfam06725 1183438011590 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1183438011591 peptidase domain interface [polypeptide binding]; other site 1183438011592 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1183438011593 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1183438011594 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1183438011595 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1183438011596 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1183438011597 Protein of unknown function (DUF433); Region: DUF433; cl01030 1183438011598 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1183438011599 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1183438011600 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438011601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438011602 active site 1183438011603 phosphorylation site [posttranslational modification] 1183438011604 intermolecular recognition site; other site 1183438011605 dimerization interface [polypeptide binding]; other site 1183438011606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438011607 DNA binding residues [nucleotide binding] 1183438011608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1183438011609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438011610 ATP binding site [chemical binding]; other site 1183438011611 Mg2+ binding site [ion binding]; other site 1183438011612 G-X-G motif; other site 1183438011613 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1183438011614 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438011615 FtsX-like permease family; Region: FtsX; pfam02687 1183438011616 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438011617 FtsX-like permease family; Region: FtsX; pfam02687 1183438011618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438011619 ABC transporter signature motif; other site 1183438011620 Walker B; other site 1183438011621 D-loop; other site 1183438011622 H-loop/switch region; other site 1183438011623 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 1183438011624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1183438011625 FeS/SAM binding site; other site 1183438011626 RND family efflux transporter MFP subunit; fragment 1183438011627 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1183438011628 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1183438011629 TM-ABC transporter signature motif; other site 1183438011630 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1183438011631 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1183438011632 putative active site [active] 1183438011633 catalytic triad [active] 1183438011634 putative dimer interface [polypeptide binding]; other site 1183438011635 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1183438011636 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1183438011637 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1183438011638 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1183438011639 active site 1183438011640 ATP binding site [chemical binding]; other site 1183438011641 substrate binding site [chemical binding]; other site 1183438011642 activation loop (A-loop); other site 1183438011643 TPR repeat; Region: TPR_11; pfam13414 1183438011644 TPR repeat; Region: TPR_11; pfam13414 1183438011645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438011646 binding surface 1183438011647 TPR motif; other site 1183438011648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1183438011649 dimerization interface [polypeptide binding]; other site 1183438011650 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438011651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438011652 putative active site [active] 1183438011653 heme pocket [chemical binding]; other site 1183438011654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438011655 dimer interface [polypeptide binding]; other site 1183438011656 phosphorylation site [posttranslational modification] 1183438011657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438011658 ATP binding site [chemical binding]; other site 1183438011659 Mg2+ binding site [ion binding]; other site 1183438011660 G-X-G motif; other site 1183438011661 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1183438011662 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438011663 active site 1183438011664 metal binding site [ion binding]; metal-binding site 1183438011665 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1183438011666 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1183438011667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438011668 putative substrate translocation pore; other site 1183438011669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438011670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1183438011671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1183438011672 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1183438011673 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1183438011674 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1183438011675 P loop; other site 1183438011676 GTP binding site [chemical binding]; other site 1183438011677 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1183438011678 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1183438011679 active site 1183438011680 metal binding site [ion binding]; metal-binding site 1183438011681 DNA binding site [nucleotide binding] 1183438011682 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1183438011683 ligand-binding site [chemical binding]; other site 1183438011684 cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665 1183438011685 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1183438011686 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1183438011687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1183438011688 Zn2+ binding site [ion binding]; other site 1183438011689 Mg2+ binding site [ion binding]; other site 1183438011690 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 1183438011691 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1183438011692 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438011693 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 1183438011694 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438011695 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 1183438011696 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438011697 putative active site [active] 1183438011698 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1183438011699 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 1183438011700 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1183438011701 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1183438011702 Predicted transcriptional regulators [Transcription]; Region: COG1695 1183438011703 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1183438011704 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1183438011705 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438011706 FtsX-like permease family; Region: FtsX; pfam02687 1183438011707 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438011708 FtsX-like permease family; Region: FtsX; pfam02687 1183438011709 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1183438011710 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1183438011711 active site 1183438011712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438011713 S-adenosylmethionine binding site [chemical binding]; other site 1183438011714 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1183438011715 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1183438011716 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1183438011717 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1183438011718 active site 1183438011719 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1183438011720 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438011721 putative active site [active] 1183438011722 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438011723 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438011724 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438011725 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438011726 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438011727 Protease prsW family; Region: PrsW-protease; pfam13367 1183438011728 Double zinc ribbon; Region: DZR; pfam12773 1183438011729 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1183438011730 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1183438011731 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438011732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438011733 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1183438011734 active site 1183438011735 iron coordination sites [ion binding]; other site 1183438011736 substrate binding pocket [chemical binding]; other site 1183438011737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1183438011738 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1183438011739 Walker A/P-loop; other site 1183438011740 ATP binding site [chemical binding]; other site 1183438011741 Q-loop/lid; other site 1183438011742 ABC transporter signature motif; other site 1183438011743 Walker B; other site 1183438011744 D-loop; other site 1183438011745 H-loop/switch region; other site 1183438011746 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1183438011747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1183438011748 dimer interface [polypeptide binding]; other site 1183438011749 conserved gate region; other site 1183438011750 putative PBP binding loops; other site 1183438011751 ABC-ATPase subunit interface; other site 1183438011752 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1183438011753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1183438011754 substrate binding pocket [chemical binding]; other site 1183438011755 membrane-bound complex binding site; other site 1183438011756 hinge residues; other site 1183438011757 XPC-binding domain; Region: XPC-binding; pfam09280 1183438011758 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 1183438011759 reactive center loop; other site 1183438011760 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1183438011761 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1183438011762 active site 1183438011763 Phycobilisome protein; Region: Phycobilisome; cl08227 1183438011764 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1183438011765 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1183438011766 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1183438011767 dimer interface [polypeptide binding]; other site 1183438011768 anticodon binding site; other site 1183438011769 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1183438011770 homodimer interface [polypeptide binding]; other site 1183438011771 motif 1; other site 1183438011772 active site 1183438011773 motif 2; other site 1183438011774 GAD domain; Region: GAD; pfam02938 1183438011775 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1183438011776 active site 1183438011777 motif 3; other site 1183438011778 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438011779 putative active site [active] 1183438011780 putative catalytic triad [active] 1183438011781 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1183438011782 Family description; Region: VCBS; pfam13517 1183438011783 Family description; Region: VCBS; pfam13517 1183438011784 Family description; Region: VCBS; pfam13517 1183438011785 Family description; Region: VCBS; pfam13517 1183438011786 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438011787 Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803 1183438011788 Family description; Region: VCBS; pfam13517 1183438011789 Family description; Region: VCBS; pfam13517 1183438011790 Family description; Region: VCBS; pfam13517 1183438011791 Family description; Region: VCBS; pfam13517 1183438011792 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1183438011793 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1183438011794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1183438011795 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1183438011796 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1183438011797 DNA binding residues [nucleotide binding] 1183438011798 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1183438011799 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1183438011800 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1183438011801 protein binding site [polypeptide binding]; other site 1183438011802 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1183438011803 putative RNA binding site [nucleotide binding]; other site 1183438011804 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1183438011805 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1183438011806 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1183438011807 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438011808 putative active site [active] 1183438011809 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 1183438011810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1183438011811 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1183438011812 putative dimerization interface [polypeptide binding]; other site 1183438011813 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1183438011814 Beta-lactamase; Region: Beta-lactamase; pfam00144 1183438011815 prephenate dehydrogenase; Validated; Region: PRK08507 1183438011816 arogenate dehydrogenase; Reviewed; Region: PRK07417 1183438011817 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1183438011818 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1183438011819 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438011820 protein binding site [polypeptide binding]; other site 1183438011821 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 1183438011822 Domain interface; other site 1183438011823 Peptide binding site; other site 1183438011824 Active site tetrad [active] 1183438011825 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1183438011826 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1183438011827 putative active site [active] 1183438011828 oxyanion strand; other site 1183438011829 catalytic triad [active] 1183438011830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1183438011831 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1183438011832 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438011833 putative active site [active] 1183438011834 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1183438011835 SGT1, suppressor of G2 allele of SKP1; Provisional; Region: PLN03088 1183438011836 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1183438011837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438011838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1183438011839 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1183438011840 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1183438011841 Protein export membrane protein; Region: SecD_SecF; cl14618 1183438011842 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1183438011843 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438011844 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438011845 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1183438011846 MarR family; Region: MarR; pfam01047 1183438011847 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438011848 putative active site [active] 1183438011849 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1183438011850 active site 1183438011851 TonB C terminal; Region: TonB_2; pfam13103 1183438011852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438011853 binding surface 1183438011854 TPR motif; other site 1183438011855 TonB C terminal; Region: TonB_2; pfam13103 1183438011856 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 1183438011857 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1183438011858 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1183438011859 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1183438011860 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1183438011861 SNF-7-like protein; Provisional; Region: PTZ00464 1183438011862 DNA polymerase III subunit delta; Validated; Region: PRK07452 1183438011863 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1183438011864 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1183438011865 C-terminal peptidase (prc); Region: prc; TIGR00225 1183438011866 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1183438011867 protein binding site [polypeptide binding]; other site 1183438011868 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1183438011869 Catalytic dyad [active] 1183438011870 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1183438011871 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1183438011872 catalytic triad [active] 1183438011873 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1183438011874 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1183438011875 catalytic triad [active] 1183438011876 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1183438011877 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1183438011878 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1183438011879 HIGH motif; other site 1183438011880 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1183438011881 active site 1183438011882 KMSKS motif; other site 1183438011883 S-layer homology domain; Region: SLH; pfam00395 1183438011884 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1183438011885 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1183438011886 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1183438011887 Stage II sporulation protein; Region: SpoIID; pfam08486 1183438011888 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1183438011889 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1183438011890 DHH family; Region: DHH; pfam01368 1183438011891 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1183438011892 O-Antigen ligase; Region: Wzy_C; pfam04932 1183438011893 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1183438011894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1183438011895 S-adenosylmethionine binding site [chemical binding]; other site 1183438011896 tellurium resistance terB-like protein; Region: terB_like; cd07177 1183438011897 metal binding site [ion binding]; metal-binding site 1183438011898 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1183438011899 pheophytin binding site; other site 1183438011900 chlorophyll binding site; other site 1183438011901 quinone binding site; other site 1183438011902 Fe binding site [ion binding]; other site 1183438011903 AAA ATPase domain; Region: AAA_16; pfam13191 1183438011904 NACHT domain; Region: NACHT; pfam05729 1183438011905 WD40 repeats; Region: WD40; smart00320 1183438011906 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438011907 structural tetrad; other site 1183438011908 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1183438011909 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1183438011910 structural tetrad; other site 1183438011911 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1183438011912 phosphopeptide binding site; other site 1183438011913 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1183438011914 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1183438011915 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1183438011916 NADP binding site [chemical binding]; other site 1183438011917 active site 1183438011918 putative substrate binding site [chemical binding]; other site 1183438011919 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 1183438011920 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1183438011921 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1183438011922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1183438011923 Walker A motif; other site 1183438011924 ATP binding site [chemical binding]; other site 1183438011925 Walker B motif; other site 1183438011926 The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720 1183438011927 PB1 interaction surface [polypeptide binding]; other site 1183438011928 arginine finger; other site 1183438011929 PB1 interaction site [polypeptide binding]; other site 1183438011930 PB1 interaction site [polypeptide binding]; other site 1183438011931 PB1 interaction surface [polypeptide binding]; other site 1183438011932 PB1 interaction surface [polypeptide binding]; other site 1183438011933 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1183438011934 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1183438011935 Predicted transcriptional regulators [Transcription]; Region: COG1733 1183438011936 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1183438011937 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1183438011938 NIPSNAP; Region: NIPSNAP; pfam07978 1183438011939 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1183438011940 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1183438011941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438011942 motif II; other site 1183438011943 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438011944 putative active site [active] 1183438011945 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1183438011946 Ligand Binding Site [chemical binding]; other site 1183438011947 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1183438011948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1183438011949 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1183438011950 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1183438011951 metal binding site [ion binding]; metal-binding site 1183438011952 active site 1183438011953 I-site; other site 1183438011954 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438011955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438011956 active site 1183438011957 phosphorylation site [posttranslational modification] 1183438011958 intermolecular recognition site; other site 1183438011959 dimerization interface [polypeptide binding]; other site 1183438011960 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1183438011961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1183438011962 putative active site [active] 1183438011963 heme pocket [chemical binding]; other site 1183438011964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438011965 dimer interface [polypeptide binding]; other site 1183438011966 phosphorylation site [posttranslational modification] 1183438011967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438011968 ATP binding site [chemical binding]; other site 1183438011969 Mg2+ binding site [ion binding]; other site 1183438011970 G-X-G motif; other site 1183438011971 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1183438011972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438011973 active site 1183438011974 phosphorylation site [posttranslational modification] 1183438011975 intermolecular recognition site; other site 1183438011976 dimerization interface [polypeptide binding]; other site 1183438011977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1183438011978 DNA binding site [nucleotide binding] 1183438011979 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1183438011980 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1183438011981 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1183438011982 phosphate binding site [ion binding]; other site 1183438011983 putative substrate binding pocket [chemical binding]; other site 1183438011984 dimer interface [polypeptide binding]; other site 1183438011985 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1183438011986 hydrophobic ligand binding site; other site 1183438011987 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1183438011988 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1183438011989 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1183438011990 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1183438011991 Protein export membrane protein; Region: SecD_SecF; pfam02355 1183438011992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1183438011993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438011994 active site 1183438011995 phosphorylation site [posttranslational modification] 1183438011996 intermolecular recognition site; other site 1183438011997 dimerization interface [polypeptide binding]; other site 1183438011998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1183438011999 DNA binding residues [nucleotide binding] 1183438012000 dimerization interface [polypeptide binding]; other site 1183438012001 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1183438012002 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1183438012003 DNA binding residues [nucleotide binding] 1183438012004 Response regulator receiver domain; Region: Response_reg; pfam00072 1183438012005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1183438012006 active site 1183438012007 phosphorylation site [posttranslational modification] 1183438012008 intermolecular recognition site; other site 1183438012009 dimerization interface [polypeptide binding]; other site 1183438012010 SdiA-regulated; Region: SdiA-regulated; cd09971 1183438012011 NHL repeat; Region: NHL; pfam01436 1183438012012 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1183438012013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1183438012014 Zn2+ binding site [ion binding]; other site 1183438012015 Mg2+ binding site [ion binding]; other site 1183438012016 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1183438012017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1183438012018 dimer interface [polypeptide binding]; other site 1183438012019 phosphorylation site [posttranslational modification] 1183438012020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1183438012021 ATP binding site [chemical binding]; other site 1183438012022 Mg2+ binding site [ion binding]; other site 1183438012023 G-X-G motif; other site 1183438012024 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 1183438012025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1183438012026 binding surface 1183438012027 TPR motif; other site 1183438012028 seryl-tRNA synthetase; Provisional; Region: PRK05431 1183438012029 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1183438012030 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1183438012031 dimer interface [polypeptide binding]; other site 1183438012032 active site 1183438012033 motif 1; other site 1183438012034 motif 2; other site 1183438012035 motif 3; other site 1183438012036 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1183438012037 MarR family; Region: MarR_2; cl17246 1183438012038 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1183438012039 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1183438012040 HlyD family secretion protein; Region: HlyD_3; pfam13437 1183438012041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438012042 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1183438012043 putative substrate translocation pore; other site 1183438012044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1183438012045 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1183438012046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1183438012047 motif II; other site 1183438012048 RF-1 domain; Region: RF-1; pfam00472 1183438012049 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1183438012050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1183438012051 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1183438012052 catalytic residues [active] 1183438012053 dimer interface [polypeptide binding]; other site 1183438012054 DNA methylase; Region: N6_N4_Mtase; pfam01555 1183438012055 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1183438012056 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1183438012057 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1183438012058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1183438012059 ATP binding site [chemical binding]; other site 1183438012060 putative Mg++ binding site [ion binding]; other site 1183438012061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1183438012062 nucleotide binding region [chemical binding]; other site 1183438012063 ATP-binding site [chemical binding]; other site 1183438012064 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1183438012065 putative active site [active] 1183438012066 O-Antigen ligase; Region: Wzy_C; cl04850 1183438012067 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1183438012068 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1183438012069 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1183438012070 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1183438012071 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1183438012072 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1183438012073 catalytic site [active] 1183438012074 putative active site [active] 1183438012075 putative substrate binding site [chemical binding]; other site 1183438012076 thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339 1183438012077 TCP-1/cpn60 chaperonin family; Region: Cpn60_TCP1; pfam00118 1183438012078 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 1183438012079 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1183438012080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438012081 active site 1183438012082 catalytic tetrad [active] 1183438012083 DJ-1 family protein; Region: not_thiJ; TIGR01383 1183438012084 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1183438012085 conserved cys residue [active] 1183438012086 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1183438012087 PilT fragment 1183438012088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1183438012089 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1183438012090 Probable transposase; Region: OrfB_IS605; pfam01385 1183438012091 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1183438012092 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1183438012093 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1183438012094 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1183438012095 active site 1183438012096 dimer interface [polypeptide binding]; other site 1183438012097 non-prolyl cis peptide bond; other site 1183438012098 insertion regions; other site 1183438012099 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1183438012100 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1183438012101 active site 1183438012102 catalytic tetrad [active] 1183438012103 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1183438012104 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1183438012105 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1183438012106 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1183438012107 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1183438012108 active site 1183438012109 antiporter inner membrane protein; Provisional; Region: PRK11670 1183438012110 Domain of unknown function DUF59; Region: DUF59; pfam01883 1183438012111 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1183438012112 PIN domain; Region: PIN_2; pfam10130 1183438012113 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1183438012114 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1183438012115 Predicted transcriptional regulators [Transcription]; Region: COG1695 1183438012116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1183438012117 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1183438012118 Bacterial PH domain; Region: DUF304; pfam03703 1183438012119 Ribonuclease P; Region: Ribonuclease_P; cl00457