-- dump date   	20140619_103050
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
251221000001	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
251221000002	putative metal binding site [ion binding]; other site
251221000003	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
251221000004	putative DNA binding site [nucleotide binding]; other site
251221000005	dimerization interface [polypeptide binding]; other site
251221000006	putative Zn2+ binding site [ion binding]; other site
251221000007	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
251221000008	amphipathic channel; other site
251221000009	Asn-Pro-Ala signature motifs; other site
251221000010	Low molecular weight phosphatase family; Region: LMWPc; cd00115
251221000011	active site
251221000012	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
251221000013	Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053
251221000014	active site
251221000015	catalytic residues [active]
251221000016	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
251221000017	dimerization interface [polypeptide binding]; other site
251221000018	putative DNA binding site [nucleotide binding]; other site
251221000019	putative Zn2+ binding site [ion binding]; other site
251221000020	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221000021	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
251221000022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221000023	dimer interface [polypeptide binding]; other site
251221000024	conserved gate region; other site
251221000025	putative PBP binding loops; other site
251221000026	ABC-ATPase subunit interface; other site
251221000027	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
251221000028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221000029	dimer interface [polypeptide binding]; other site
251221000030	conserved gate region; other site
251221000031	ABC-ATPase subunit interface; other site
251221000032	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
251221000033	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
251221000034	Walker A/P-loop; other site
251221000035	ATP binding site [chemical binding]; other site
251221000036	Q-loop/lid; other site
251221000037	ABC transporter signature motif; other site
251221000038	Walker B; other site
251221000039	D-loop; other site
251221000040	H-loop/switch region; other site
251221000041	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221000042	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221000043	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221000044	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221000045	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221000046	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
251221000047	putative active site pocket [active]
251221000048	dimerization interface [polypeptide binding]; other site
251221000049	putative catalytic residue [active]
251221000050	Outer membrane efflux protein; Region: OEP; pfam02321
251221000051	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
251221000052	Outer membrane efflux protein; Region: OEP; pfam02321
251221000053	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221000054	HlyD family secretion protein; Region: HlyD; pfam00529
251221000055	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
251221000056	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221000057	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221000058	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221000059	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221000060	Walker A/P-loop; other site
251221000061	ATP binding site [chemical binding]; other site
251221000062	Q-loop/lid; other site
251221000063	ABC transporter signature motif; other site
251221000064	Walker B; other site
251221000065	D-loop; other site
251221000066	H-loop/switch region; other site
251221000067	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221000068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000069	active site
251221000070	phosphorylation site [posttranslational modification]
251221000071	intermolecular recognition site; other site
251221000072	dimerization interface [polypeptide binding]; other site
251221000073	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221000074	DNA binding site [nucleotide binding]
251221000075	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
251221000076	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221000077	dimerization interface [polypeptide binding]; other site
251221000078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221000079	dimer interface [polypeptide binding]; other site
251221000080	phosphorylation site [posttranslational modification]
251221000081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221000082	ATP binding site [chemical binding]; other site
251221000083	Mg2+ binding site [ion binding]; other site
251221000084	G-X-G motif; other site
251221000085	primosome assembly protein PriA; Validated; Region: PRK05580
251221000086	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221000087	ATP binding site [chemical binding]; other site
251221000088	putative Mg++ binding site [ion binding]; other site
251221000089	Domain of unknown function (DUF4042); Region: DUF4042; pfam13251
251221000090	helicase superfamily c-terminal domain; Region: HELICc; smart00490
251221000091	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
251221000092	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
251221000093	iron-sulfur cluster [ion binding]; other site
251221000094	[2Fe-2S] cluster binding site [ion binding]; other site
251221000095	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
251221000096	hydrophobic ligand binding site; other site
251221000097	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
251221000098	hydrophobic ligand binding site; other site
251221000099	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
251221000100	putative catalytic residues [active]
251221000101	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
251221000102	tetramer (dimer of dimers) interface [polypeptide binding]; other site
251221000103	active site
251221000104	dimer interface [polypeptide binding]; other site
251221000105	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
251221000106	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
251221000107	active site
251221000108	SAM binding site [chemical binding]; other site
251221000109	homodimer interface [polypeptide binding]; other site
251221000110	PAS fold; Region: PAS_4; pfam08448
251221000111	RD3 protein; Region: RD3; pfam14473
251221000112	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221000113	dimer interface [polypeptide binding]; other site
251221000114	phosphorylation site [posttranslational modification]
251221000115	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221000116	ATP binding site [chemical binding]; other site
251221000117	Mg2+ binding site [ion binding]; other site
251221000118	G-X-G motif; other site
251221000119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000120	active site
251221000121	phosphorylation site [posttranslational modification]
251221000122	intermolecular recognition site; other site
251221000123	dimerization interface [polypeptide binding]; other site
251221000124	replicative DNA helicase; Region: DnaB; TIGR00665
251221000125	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
251221000126	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
251221000127	Walker A motif; other site
251221000128	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
251221000129	protein-splicing catalytic site; other site
251221000130	thioester formation/cholesterol transfer; other site
251221000131	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
251221000132	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
251221000133	ATP binding site [chemical binding]; other site
251221000134	Walker B motif; other site
251221000135	DNA binding loops [nucleotide binding]
251221000136	Asparaginase [Amino acid transport and metabolism]; Region: COG1446
251221000137	active site
251221000138	dimer interface [polypeptide binding]; other site
251221000139	catalytic nucleophile [active]
251221000140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
251221000141	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
251221000142	Domain of unknown function (DUF4480); Region: DUF4480; pfam13715
251221000143	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
251221000144	active site residue [active]
251221000145	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000146	putative active site [active]
251221000147	CsbD-like; Region: CsbD; pfam05532
251221000148	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
251221000149	DHH family; Region: DHH; pfam01368
251221000150	DHHA1 domain; Region: DHHA1; pfam02272
251221000151	adenylosuccinate lyase; Provisional; Region: PRK07380
251221000152	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
251221000153	tetramer interface [polypeptide binding]; other site
251221000154	active site
251221000155	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
251221000156	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221000157	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221000158	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221000159	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221000160	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221000161	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221000162	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
251221000163	putative homodimer interface [polypeptide binding]; other site
251221000164	putative homotetramer interface [polypeptide binding]; other site
251221000165	putative metal binding site [ion binding]; other site
251221000166	putative homodimer-homodimer interface [polypeptide binding]; other site
251221000167	putative allosteric switch controlling residues; other site
251221000168	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
251221000169	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
251221000170	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
251221000171	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
251221000172	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
251221000173	ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266
251221000174	Walker A/P-loop; other site
251221000175	ATP binding site [chemical binding]; other site
251221000176	Q-loop/lid; other site
251221000177	ABC transporter signature motif; other site
251221000178	Walker B; other site
251221000179	D-loop; other site
251221000180	H-loop/switch region; other site
251221000181	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221000182	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
251221000183	TAP-like protein; Region: Abhydrolase_4; pfam08386
251221000184	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221000185	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221000186	active site
251221000187	ATP binding site [chemical binding]; other site
251221000188	substrate binding site [chemical binding]; other site
251221000189	activation loop (A-loop); other site
251221000190	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221000191	dimerization interface [polypeptide binding]; other site
251221000192	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
251221000193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221000194	putative active site [active]
251221000195	heme pocket [chemical binding]; other site
251221000196	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221000197	dimer interface [polypeptide binding]; other site
251221000198	phosphorylation site [posttranslational modification]
251221000199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221000200	ATP binding site [chemical binding]; other site
251221000201	Mg2+ binding site [ion binding]; other site
251221000202	G-X-G motif; other site
251221000203	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
251221000204	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
251221000205	active site
251221000206	metal binding site [ion binding]; metal-binding site
251221000207	active site
251221000208	metal binding site [ion binding]; metal-binding site
251221000209	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
251221000210	Domain of unknown function (DUF4480); Region: DUF4480; pfam13715
251221000211	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
251221000212	Ca2+ binding site [ion binding]; other site
251221000213	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
251221000214	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
251221000215	Ca2+ binding site [ion binding]; other site
251221000216	Domain of unknown function (DUF4480); Region: DUF4480; pfam13715
251221000217	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
251221000218	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221000219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000220	active site
251221000221	phosphorylation site [posttranslational modification]
251221000222	intermolecular recognition site; other site
251221000223	dimerization interface [polypeptide binding]; other site
251221000224	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221000225	DNA binding residues [nucleotide binding]
251221000226	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221000227	active site
251221000228	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
251221000229	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
251221000230	DNA polymerase III subunit delta; Validated; Region: PRK07452
251221000231	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
251221000232	Tricorn protease C1 domain; Region: Tricorn_C1; pfam14684
251221000233	carboxyl-terminal processing protease; Provisional; Region: PLN00049
251221000234	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
251221000235	protein binding site [polypeptide binding]; other site
251221000236	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
251221000237	Catalytic dyad [active]
251221000238	Hpt domain; Region: Hpt; pfam01627
251221000239	putative binding surface; other site
251221000240	active site
251221000241	gamma-glutamyl kinase; Provisional; Region: PRK05429
251221000242	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
251221000243	nucleotide binding site [chemical binding]; other site
251221000244	homotetrameric interface [polypeptide binding]; other site
251221000245	putative phosphate binding site [ion binding]; other site
251221000246	putative allosteric binding site; other site
251221000247	PUA domain; Region: PUA; pfam01472
251221000248	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
251221000249	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
251221000250	inhibitor-cofactor binding pocket; inhibition site
251221000251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221000252	catalytic residue [active]
251221000253	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
251221000254	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
251221000255	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
251221000256	RNA binding surface [nucleotide binding]; other site
251221000257	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
251221000258	active site
251221000259	Immunity protein 29; Region: Imm29; pfam15575
251221000260	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
251221000261	active site
251221000262	substrate binding site [chemical binding]; other site
251221000263	Mg2+ binding site [ion binding]; other site
251221000264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
251221000265	Transposase; Region: HTH_Tnp_1; cl17663
251221000266	putative transposase OrfB; Reviewed; Region: PHA02517
251221000267	HTH-like domain; Region: HTH_21; pfam13276
251221000268	Integrase core domain; Region: rve; pfam00665
251221000269	Integrase core domain; Region: rve_3; pfam13683
251221000270	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
251221000271	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
251221000272	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
251221000273	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
251221000274	active site
251221000275	catalytic site [active]
251221000276	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
251221000277	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
251221000278	Rhomboid family; Region: Rhomboid; pfam01694
251221000279	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221000280	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
251221000281	H+ Antiporter protein; Region: 2A0121; TIGR00900
251221000282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221000283	putative substrate translocation pore; other site
251221000284	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
251221000285	Recombination protein O N terminal; Region: RecO_N; pfam11967
251221000286	Recombination protein O C terminal; Region: RecO_C; pfam02565
251221000287	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
251221000288	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
251221000289	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
251221000290	BON domain; Region: BON; pfam04972
251221000291	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221000292	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
251221000293	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
251221000294	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
251221000295	proline aminopeptidase P II; Provisional; Region: PRK10879
251221000296	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
251221000297	active site
251221000298	Caspase domain; Region: Peptidase_C14; pfam00656
251221000299	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
251221000300	PemK-like protein; Region: PemK; cl00995
251221000301	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
251221000302	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
251221000303	ABC transporter; Region: ABC_tran_2; pfam12848
251221000304	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
251221000305	ABC transporter; Region: ABC_tran_2; pfam12848
251221000306	PAS domain S-box; Region: sensory_box; TIGR00229
251221000307	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221000308	putative active site [active]
251221000309	heme pocket [chemical binding]; other site
251221000310	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
251221000311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221000312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221000313	dimer interface [polypeptide binding]; other site
251221000314	phosphorylation site [posttranslational modification]
251221000315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221000316	ATP binding site [chemical binding]; other site
251221000317	Mg2+ binding site [ion binding]; other site
251221000318	G-X-G motif; other site
251221000319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000320	active site
251221000321	phosphorylation site [posttranslational modification]
251221000322	intermolecular recognition site; other site
251221000323	dimerization interface [polypeptide binding]; other site
251221000324	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
251221000325	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
251221000326	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
251221000327	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
251221000328	active site
251221000329	hydrophilic channel; other site
251221000330	dimerization interface [polypeptide binding]; other site
251221000331	catalytic residues [active]
251221000332	active site lid [active]
251221000333	Predicted membrane protein [Function unknown]; Region: COG2261
251221000334	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221000335	Coenzyme A binding pocket [chemical binding]; other site
251221000336	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
251221000337	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
251221000338	active site
251221000339	dimer interface [polypeptide binding]; other site
251221000340	Uncharacterized conserved protein [Function unknown]; Region: COG1624
251221000341	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
251221000342	diaminopimelate decarboxylase; Region: lysA; TIGR01048
251221000343	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
251221000344	active site
251221000345	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
251221000346	substrate binding site [chemical binding]; other site
251221000347	catalytic residues [active]
251221000348	dimer interface [polypeptide binding]; other site
251221000349	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
251221000350	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
251221000351	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
251221000352	classical (c) SDRs; Region: SDR_c; cd05233
251221000353	NAD(P) binding site [chemical binding]; other site
251221000354	active site
251221000355	EcsC protein family; Region: EcsC; pfam12787
251221000356	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
251221000357	proposed catalytic triad [active]
251221000358	active site nucleophile [active]
251221000359	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
251221000360	Tricorn protease C1 domain; Region: Tricorn_C1; pfam14684
251221000361	C-terminal peptidase (prc); Region: prc; TIGR00225
251221000362	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
251221000363	protein binding site [polypeptide binding]; other site
251221000364	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
251221000365	Catalytic dyad [active]
251221000366	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
251221000367	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221000368	active site
251221000369	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
251221000370	active site
251221000371	metal binding site [ion binding]; metal-binding site
251221000372	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
251221000373	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
251221000374	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
251221000375	Predicted membrane protein [Function unknown]; Region: COG2259
251221000376	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
251221000377	PemK-like protein; Region: PemK; pfam02452
251221000378	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
251221000379	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221000380	S-adenosylmethionine binding site [chemical binding]; other site
251221000381	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
251221000382	GTP binding site; other site
251221000383	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
251221000384	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221000385	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
251221000386	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
251221000387	substrate binding pocket [chemical binding]; other site
251221000388	membrane-bound complex binding site; other site
251221000389	hinge residues; other site
251221000390	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
251221000391	dimer interface [polypeptide binding]; other site
251221000392	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
251221000393	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221000394	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000395	putative active site [active]
251221000396	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
251221000397	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
251221000398	putative catalytic site [active]
251221000399	putative phosphate binding site [ion binding]; other site
251221000400	active site
251221000401	metal binding site A [ion binding]; metal-binding site
251221000402	DNA binding site [nucleotide binding]
251221000403	putative AP binding site [nucleotide binding]; other site
251221000404	putative metal binding site B [ion binding]; other site
251221000405	SnoaL-like domain; Region: SnoaL_3; pfam13474
251221000406	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
251221000407	ATP cone domain; Region: ATP-cone; pfam03477
251221000408	Transposase DNA-binding; Region: Tnp_DNA_bind; pfam14706
251221000409	Transposase Tn5 dimerization domain; Region: Dimer_Tnp_Tn5; pfam02281
251221000410	Helix-turn-helix domain; Region: HTH_36; pfam13730
251221000411	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
251221000412	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
251221000413	P-loop; other site
251221000414	Magnesium ion binding site [ion binding]; other site
251221000415	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
251221000416	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221000417	Transposase domain (DUF772); Region: DUF772; pfam05598
251221000418	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
251221000419	Clp amino terminal domain; Region: Clp_N; pfam02861
251221000420	Clp amino terminal domain; Region: Clp_N; pfam02861
251221000421	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221000422	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
251221000423	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221000424	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
251221000425	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
251221000426	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
251221000427	active site
251221000428	acetyl-CoA synthetase; Provisional; Region: PRK00174
251221000429	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
251221000430	active site
251221000431	CoA binding site [chemical binding]; other site
251221000432	acyl-activating enzyme (AAE) consensus motif; other site
251221000433	AMP binding site [chemical binding]; other site
251221000434	acetate binding site [chemical binding]; other site
251221000435	ribosomal protein S20; Region: rps20; CHL00102
251221000436	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
251221000437	Transglycosylase; Region: Transgly; pfam00912
251221000438	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
251221000439	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
251221000440	putative rRNA binding site [nucleotide binding]; other site
251221000441	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
251221000442	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
251221000443	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
251221000444	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
251221000445	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
251221000446	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
251221000447	C-terminal domain interface [polypeptide binding]; other site
251221000448	active site
251221000449	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
251221000450	active site
251221000451	N-terminal domain interface [polypeptide binding]; other site
251221000452	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
251221000453	putative di-iron ligands [ion binding]; other site
251221000454	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
251221000455	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
251221000456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221000457	dimer interface [polypeptide binding]; other site
251221000458	conserved gate region; other site
251221000459	putative PBP binding loops; other site
251221000460	ABC-ATPase subunit interface; other site
251221000461	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
251221000462	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
251221000463	Walker A/P-loop; other site
251221000464	ATP binding site [chemical binding]; other site
251221000465	Q-loop/lid; other site
251221000466	ABC transporter signature motif; other site
251221000467	Walker B; other site
251221000468	D-loop; other site
251221000469	H-loop/switch region; other site
251221000470	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
251221000471	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221000472	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
251221000473	membrane-bound complex binding site; other site
251221000474	hinge residues; other site
251221000475	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
251221000476	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221000477	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221000478	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
251221000479	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
251221000480	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
251221000481	putative active site [active]
251221000482	putative NTP binding site [chemical binding]; other site
251221000483	putative nucleic acid binding site [nucleotide binding]; other site
251221000484	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
251221000485	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
251221000486	active site
251221000487	Uncharacterized conserved protein [Function unknown]; Region: COG5464
251221000488	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
251221000489	Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; Region: Amicyanin; cd13921
251221000490	Type 1 (T1) Cu binding site [ion binding]; other site
251221000491	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
251221000492	dinuclear metal binding motif [ion binding]; other site
251221000493	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
251221000494	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
251221000495	active site
251221000496	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221000497	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221000498	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221000499	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
251221000500	active site
251221000501	catalytic tetrad [active]
251221000502	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
251221000503	active site
251221000504	quinolinate synthetase; Provisional; Region: PRK09375
251221000505	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
251221000506	DAHP synthetase I family; Region: DAHP_synth_1; cl17225
251221000507	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
251221000508	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
251221000509	TPP-binding site; other site
251221000510	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
251221000511	PYR/PP interface [polypeptide binding]; other site
251221000512	dimer interface [polypeptide binding]; other site
251221000513	TPP binding site [chemical binding]; other site
251221000514	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
251221000515	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
251221000516	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
251221000517	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
251221000518	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
251221000519	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
251221000520	trimer interface [polypeptide binding]; other site
251221000521	active site
251221000522	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
251221000523	catalytic site [active]
251221000524	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
251221000525	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
251221000526	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
251221000527	active site residue [active]
251221000528	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
251221000529	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
251221000530	Transposase; Region: DEDD_Tnp_IS110; pfam01548
251221000531	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
251221000532	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
251221000533	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
251221000534	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221000535	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
251221000536	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221000537	DNA binding residues [nucleotide binding]
251221000538	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
251221000539	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; cl19160
251221000540	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221000541	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221000542	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221000543	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
251221000544	protein-splicing catalytic site; other site
251221000545	thioester formation/cholesterol transfer; other site
251221000546	Pretoxin HINT domain; Region: PT-HINT; pfam07591
251221000547	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221000548	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
251221000549	IPT/TIG domain; Region: TIG; pfam01833
251221000550	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
251221000551	protein-splicing catalytic site; other site
251221000552	thioester formation/cholesterol transfer; other site
251221000553	Pretoxin HINT domain; Region: PT-HINT; pfam07591
251221000554	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
251221000555	protein-splicing catalytic site; other site
251221000556	thioester formation/cholesterol transfer; other site
251221000557	Pretoxin HINT domain; Region: PT-HINT; pfam07591
251221000558	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
251221000559	RHS Repeat; Region: RHS_repeat; pfam05593
251221000560	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
251221000561	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
251221000562	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
251221000563	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
251221000564	Solibacter uncharacterized C-terminal domain; Region: Soli_cterm; TIGR03437
251221000565	tail sheath protein; Provisional; Region: 18; PHA02539
251221000566	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
251221000567	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
251221000568	protein-splicing catalytic site; other site
251221000569	thioester formation/cholesterol transfer; other site
251221000570	Pretoxin HINT domain; Region: PT-HINT; pfam07591
251221000571	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
251221000572	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
251221000573	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
251221000574	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
251221000575	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
251221000576	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
251221000577	active site
251221000578	Riboflavin kinase; Region: Flavokinase; pfam01687
251221000579	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
251221000580	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
251221000581	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221000582	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
251221000583	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
251221000584	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221000585	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
251221000586	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221000587	DNA binding residues [nucleotide binding]
251221000588	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
251221000589	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
251221000590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000591	active site
251221000592	phosphorylation site [posttranslational modification]
251221000593	intermolecular recognition site; other site
251221000594	dimerization interface [polypeptide binding]; other site
251221000595	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
251221000596	Predicted transcriptional regulators [Transcription]; Region: COG1695
251221000597	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
251221000598	RNA binding surface [nucleotide binding]; other site
251221000599	Yqey-like protein; Region: YqeY; cl17540
251221000600	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
251221000601	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
251221000602	conjugal transfer protein TrbL; Provisional; Region: PRK13875
251221000603	Immunity protein 29; Region: Imm29; pfam15575
251221000604	Immunity protein 29; Region: Imm29; pfam15575
251221000605	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
251221000606	MMPL family; Region: MMPL; cl14618
251221000607	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221000608	Protein of unknown function; Region: DUF3971; pfam13116
251221000609	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
251221000610	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
251221000611	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
251221000612	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
251221000613	active site
251221000614	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
251221000615	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221000616	Coenzyme A binding pocket [chemical binding]; other site
251221000617	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
251221000618	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221000619	Walker A motif; other site
251221000620	ATP binding site [chemical binding]; other site
251221000621	Walker B motif; other site
251221000622	arginine finger; other site
251221000623	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221000624	Walker A motif; other site
251221000625	ATP binding site [chemical binding]; other site
251221000626	Walker B motif; other site
251221000627	arginine finger; other site
251221000628	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
251221000629	active site
251221000630	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221000631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000632	active site
251221000633	phosphorylation site [posttranslational modification]
251221000634	intermolecular recognition site; other site
251221000635	dimerization interface [polypeptide binding]; other site
251221000636	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221000637	DNA binding residues [nucleotide binding]
251221000638	dimerization interface [polypeptide binding]; other site
251221000639	Heat induced stress protein YflT; Region: YflT; pfam11181
251221000640	glycine dehydrogenase; Provisional; Region: PRK05367
251221000641	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
251221000642	tetramer interface [polypeptide binding]; other site
251221000643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221000644	catalytic residue [active]
251221000645	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
251221000646	tetramer interface [polypeptide binding]; other site
251221000647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221000648	catalytic residue [active]
251221000649	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
251221000650	PIN domain; Region: PIN_3; cl17397
251221000651	Cell adhesion-like domain, left-handed beta-roll; Region: LbR_vir_like; cd12819
251221000652	putative trimer interface [polypeptide binding]; other site
251221000653	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
251221000654	Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962
251221000655	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
251221000656	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
251221000657	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
251221000658	P loop; other site
251221000659	GTP binding site [chemical binding]; other site
251221000660	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
251221000661	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
251221000662	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221000663	active site
251221000664	motif I; other site
251221000665	motif II; other site
251221000666	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
251221000667	DRTGG domain; Region: DRTGG; pfam07085
251221000668	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
251221000669	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
251221000670	SnoaL-like domain; Region: SnoaL_2; pfam12680
251221000671	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
251221000672	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
251221000673	Rap1-interacting factor 1 N terminal; Region: Rif1_N; pfam12231
251221000674	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
251221000675	TPR repeat; Region: TPR_11; pfam13414
251221000676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221000677	binding surface
251221000678	TPR motif; other site
251221000679	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
251221000680	MMPL family; Region: MMPL; cl14618
251221000681	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
251221000682	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
251221000683	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221000684	non-specific DNA binding site [nucleotide binding]; other site
251221000685	salt bridge; other site
251221000686	sequence-specific DNA binding site [nucleotide binding]; other site
251221000687	Domain of unknown function (DUF955); Region: DUF955; cl01076
251221000688	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221000689	Major Facilitator Superfamily; Region: MFS_1; pfam07690
251221000690	putative substrate translocation pore; other site
251221000691	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
251221000692	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
251221000693	Walker A/P-loop; other site
251221000694	ATP binding site [chemical binding]; other site
251221000695	Q-loop/lid; other site
251221000696	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
251221000697	ABC transporter signature motif; other site
251221000698	Walker B; other site
251221000699	D-loop; other site
251221000700	H-loop/switch region; other site
251221000701	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221000702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000703	active site
251221000704	phosphorylation site [posttranslational modification]
251221000705	intermolecular recognition site; other site
251221000706	dimerization interface [polypeptide binding]; other site
251221000707	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221000708	DNA binding residues [nucleotide binding]
251221000709	dimerization interface [polypeptide binding]; other site
251221000710	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
251221000711	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221000712	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221000713	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
251221000714	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
251221000715	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
251221000716	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
251221000717	Phosphoesterase family; Region: Phosphoesterase; pfam04185
251221000718	Uncharacterized conserved protein [Function unknown]; Region: COG3391
251221000719	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
251221000720	Uncharacterized conserved protein [Function unknown]; Region: COG3391
251221000721	Phosphoesterase family; Region: Phosphoesterase; pfam04185
251221000722	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
251221000723	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
251221000724	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
251221000725	PIN domain; Region: PIN_3; cl17397
251221000726	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
251221000727	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000728	N-terminal plug; other site
251221000729	ligand-binding site [chemical binding]; other site
251221000730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221000731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000732	active site
251221000733	phosphorylation site [posttranslational modification]
251221000734	intermolecular recognition site; other site
251221000735	dimerization interface [polypeptide binding]; other site
251221000736	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221000737	DNA binding site [nucleotide binding]
251221000738	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
251221000739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221000740	dimer interface [polypeptide binding]; other site
251221000741	phosphorylation site [posttranslational modification]
251221000742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221000743	ATP binding site [chemical binding]; other site
251221000744	Mg2+ binding site [ion binding]; other site
251221000745	G-X-G motif; other site
251221000746	Tocopherol phytyltransferase; Region: PT_UbiA_HPT1; cd13960
251221000747	putative active site [active]
251221000748	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
251221000749	TPR repeat; Region: TPR_11; pfam13414
251221000750	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221000751	binding surface
251221000752	TPR motif; other site
251221000753	TPR repeat; Region: TPR_11; pfam13414
251221000754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221000755	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
251221000756	hinge region; other site
251221000757	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
251221000758	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
251221000759	Walker A/P-loop; other site
251221000760	ATP binding site [chemical binding]; other site
251221000761	Q-loop/lid; other site
251221000762	ABC transporter signature motif; other site
251221000763	Walker B; other site
251221000764	D-loop; other site
251221000765	H-loop/switch region; other site
251221000766	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
251221000767	PDGLE domain; Region: PDGLE; pfam13190
251221000768	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
251221000769	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
251221000770	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
251221000771	NADP binding site [chemical binding]; other site
251221000772	substrate binding site [chemical binding]; other site
251221000773	active site
251221000774	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
251221000775	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
251221000776	conserved cys residue [active]
251221000777	GAF domain; Region: GAF; cl17456
251221000778	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221000779	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221000780	DNA binding residues [nucleotide binding]
251221000781	dimerization interface [polypeptide binding]; other site
251221000782	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221000783	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
251221000784	Coenzyme A binding pocket [chemical binding]; other site
251221000785	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
251221000786	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
251221000787	ATP-grasp domain; Region: ATP-grasp_4; cl17255
251221000788	cell division protein FtsZ; Validated; Region: PRK09330
251221000789	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
251221000790	nucleotide binding site [chemical binding]; other site
251221000791	SulA interaction site; other site
251221000792	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
251221000793	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
251221000794	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
251221000795	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221000796	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000797	N-terminal plug; other site
251221000798	ligand-binding site [chemical binding]; other site
251221000799	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
251221000800	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
251221000801	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000802	putative active site [active]
251221000803	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
251221000804	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
251221000805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221000806	S-adenosylmethionine binding site [chemical binding]; other site
251221000807	long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584
251221000808	flavodoxin FldA; Validated; Region: PRK09267
251221000809	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221000810	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
251221000811	putative switch regulator; other site
251221000812	non-specific DNA interactions [nucleotide binding]; other site
251221000813	DNA binding site [nucleotide binding]
251221000814	sequence specific DNA binding site [nucleotide binding]; other site
251221000815	putative cAMP binding site [chemical binding]; other site
251221000816	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000817	putative active site [active]
251221000818	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000819	putative active site [active]
251221000820	Protein of unknown function (DUF3812); Region: DUF3812; pfam12757
251221000821	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221000822	Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152
251221000823	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
251221000824	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000825	N-terminal plug; other site
251221000826	ligand-binding site [chemical binding]; other site
251221000827	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
251221000828	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
251221000829	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221000830	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000831	N-terminal plug; other site
251221000832	ligand-binding site [chemical binding]; other site
251221000833	flavodoxin FldA; Validated; Region: PRK09267
251221000834	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
251221000835	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000836	putative active site [active]
251221000837	Protein of unknown function (DUF3812); Region: DUF3812; pfam12757
251221000838	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221000839	Uncharacterized conserved protein [Function unknown]; Region: COG5464
251221000840	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221000841	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000842	N-terminal plug; other site
251221000843	ligand-binding site [chemical binding]; other site
251221000844	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
251221000845	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221000846	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221000847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221000848	Walker A/P-loop; other site
251221000849	ATP binding site [chemical binding]; other site
251221000850	Q-loop/lid; other site
251221000851	ABC transporter signature motif; other site
251221000852	Walker B; other site
251221000853	D-loop; other site
251221000854	H-loop/switch region; other site
251221000855	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221000856	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221000857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221000858	Walker A/P-loop; other site
251221000859	ATP binding site [chemical binding]; other site
251221000860	Q-loop/lid; other site
251221000861	ABC transporter signature motif; other site
251221000862	Walker B; other site
251221000863	D-loop; other site
251221000864	H-loop/switch region; other site
251221000865	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
251221000866	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221000867	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
251221000868	ligand binding site [chemical binding]; other site
251221000869	flexible hinge region; other site
251221000870	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
251221000871	putative switch regulator; other site
251221000872	non-specific DNA interactions [nucleotide binding]; other site
251221000873	DNA binding site [nucleotide binding]
251221000874	sequence specific DNA binding site [nucleotide binding]; other site
251221000875	putative cAMP binding site [chemical binding]; other site
251221000876	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
251221000877	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
251221000878	AMIN domain; Region: AMIN; pfam11741
251221000879	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221000880	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000881	N-terminal plug; other site
251221000882	ligand-binding site [chemical binding]; other site
251221000883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221000884	S-adenosylmethionine binding site [chemical binding]; other site
251221000885	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000886	putative active site [active]
251221000887	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221000888	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221000889	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000890	N-terminal plug; other site
251221000891	ligand-binding site [chemical binding]; other site
251221000892	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
251221000893	Transposase, Mutator family; Region: Transposase_mut; cl19537
251221000894	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
251221000895	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
251221000896	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
251221000897	TIGR03118 family protein; Region: PEPCTERM_chp_1
251221000898	Ferritin-like domain; Region: Ferritin; pfam00210
251221000899	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
251221000900	dimerization interface [polypeptide binding]; other site
251221000901	DPS ferroxidase diiron center [ion binding]; other site
251221000902	ion pore; other site
251221000903	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
251221000904	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
251221000905	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000906	putative active site [active]
251221000907	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
251221000908	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
251221000909	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
251221000910	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
251221000911	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221000912	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000913	N-terminal plug; other site
251221000914	ligand-binding site [chemical binding]; other site
251221000915	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000916	putative active site [active]
251221000917	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221000918	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
251221000919	FtsX-like permease family; Region: FtsX; pfam02687
251221000920	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221000921	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221000922	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
251221000923	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221000924	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
251221000925	Histidine kinase; Region: HisKA_3; pfam07730
251221000926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221000927	ATP binding site [chemical binding]; other site
251221000928	Mg2+ binding site [ion binding]; other site
251221000929	G-X-G motif; other site
251221000930	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221000931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221000932	active site
251221000933	phosphorylation site [posttranslational modification]
251221000934	intermolecular recognition site; other site
251221000935	dimerization interface [polypeptide binding]; other site
251221000936	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221000937	DNA binding residues [nucleotide binding]
251221000938	dimerization interface [polypeptide binding]; other site
251221000939	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221000940	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000941	N-terminal plug; other site
251221000942	ligand-binding site [chemical binding]; other site
251221000943	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000944	putative active site [active]
251221000945	Plasminogen-binding protein pgbA C-terminal; Region: PGBA_C; pfam15437
251221000946	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221000947	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
251221000948	DNA binding residues [nucleotide binding]
251221000949	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
251221000950	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000951	N-terminal plug; other site
251221000952	ligand-binding site [chemical binding]; other site
251221000953	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
251221000954	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221000955	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
251221000956	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
251221000957	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221000958	Uncharacterized conserved protein [Function unknown]; Region: COG5464
251221000959	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
251221000960	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221000961	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
251221000962	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221000963	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221000964	N-terminal plug; other site
251221000965	ligand-binding site [chemical binding]; other site
251221000966	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
251221000967	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
251221000968	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
251221000969	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
251221000970	PhoD-like phosphatase; Region: PhoD; pfam09423
251221000971	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
251221000972	putative active site [active]
251221000973	putative metal binding site [ion binding]; other site
251221000974	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
251221000975	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
251221000976	iron-sulfur cluster [ion binding]; other site
251221000977	[2Fe-2S] cluster binding site [ion binding]; other site
251221000978	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
251221000979	amphipathic channel; other site
251221000980	Asn-Pro-Ala signature motifs; other site
251221000981	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
251221000982	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
251221000983	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
251221000984	NAD(P) binding site [chemical binding]; other site
251221000985	Transposase DNA-binding; Region: Tnp_DNA_bind; pfam14706
251221000986	Transposase Tn5 dimerization domain; Region: Dimer_Tnp_Tn5; pfam02281
251221000987	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
251221000988	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
251221000989	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
251221000990	Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
251221000991	active site
251221000992	catalytic site [active]
251221000993	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
251221000994	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
251221000995	starch-binding site 2 [chemical binding]; other site
251221000996	starch-binding site 1 [chemical binding]; other site
251221000997	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
251221000998	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
251221000999	metal binding site [ion binding]; metal-binding site
251221001000	dimer interface [polypeptide binding]; other site
251221001001	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
251221001002	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
251221001003	active site
251221001004	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221001005	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221001006	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
251221001007	putative active site [active]
251221001008	heme pocket [chemical binding]; other site
251221001009	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221001010	putative active site [active]
251221001011	heme pocket [chemical binding]; other site
251221001012	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221001013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221001014	dimer interface [polypeptide binding]; other site
251221001015	phosphorylation site [posttranslational modification]
251221001016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221001017	ATP binding site [chemical binding]; other site
251221001018	Mg2+ binding site [ion binding]; other site
251221001019	G-X-G motif; other site
251221001020	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
251221001021	active site
251221001022	SAM binding site [chemical binding]; other site
251221001023	homodimer interface [polypeptide binding]; other site
251221001024	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
251221001025	active site
251221001026	putative homodimer interface [polypeptide binding]; other site
251221001027	SAM binding site [chemical binding]; other site
251221001028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221001029	S-adenosylmethionine binding site [chemical binding]; other site
251221001030	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221001031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001032	active site
251221001033	phosphorylation site [posttranslational modification]
251221001034	intermolecular recognition site; other site
251221001035	dimerization interface [polypeptide binding]; other site
251221001036	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221001037	DNA binding residues [nucleotide binding]
251221001038	dimerization interface [polypeptide binding]; other site
251221001039	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221001040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221001041	ATP binding site [chemical binding]; other site
251221001042	Mg2+ binding site [ion binding]; other site
251221001043	G-X-G motif; other site
251221001044	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
251221001045	Domain of unknown function DUF21; Region: DUF21; pfam01595
251221001046	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
251221001047	Transporter associated domain; Region: CorC_HlyC; smart01091
251221001048	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
251221001049	MMPL family; Region: MMPL; cl14618
251221001050	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
251221001051	putative cation:proton antiport protein; Provisional; Region: PRK10669
251221001052	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
251221001053	TrkA-N domain; Region: TrkA_N; pfam02254
251221001054	TrkA-C domain; Region: TrkA_C; pfam02080
251221001055	TrkA-C domain; Region: TrkA_C; pfam02080
251221001056	precorrin-8X methylmutase; Provisional; Region: PRK05954
251221001057	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
251221001058	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
251221001059	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
251221001060	homodimer interface [polypeptide binding]; other site
251221001061	Walker A motif; other site
251221001062	ATP binding site [chemical binding]; other site
251221001063	hydroxycobalamin binding site [chemical binding]; other site
251221001064	Walker B motif; other site
251221001065	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
251221001066	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
251221001067	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
251221001068	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
251221001069	active site
251221001070	substrate binding site [chemical binding]; other site
251221001071	metal binding site [ion binding]; metal-binding site
251221001072	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
251221001073	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
251221001074	RNA binding surface [nucleotide binding]; other site
251221001075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221001076	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
251221001077	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221001078	Tetratricopeptide repeat; Region: TPR_2; pfam07719
251221001079	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
251221001080	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
251221001081	substrate-cofactor binding pocket; other site
251221001082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221001083	catalytic residue [active]
251221001084	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
251221001085	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221001086	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
251221001087	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
251221001088	5S rRNA interface [nucleotide binding]; other site
251221001089	CTC domain interface [polypeptide binding]; other site
251221001090	L16 interface [polypeptide binding]; other site
251221001091	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
251221001092	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
251221001093	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
251221001094	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
251221001095	thiS-thiF/thiG interaction site; other site
251221001096	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
251221001097	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
251221001098	thiamine phosphate binding site [chemical binding]; other site
251221001099	active site
251221001100	pyrophosphate binding site [ion binding]; other site
251221001101	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
251221001102	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
251221001103	Sporulation related domain; Region: SPOR; pfam05036
251221001104	Sporulation related domain; Region: SPOR; pfam05036
251221001105	prephenate dehydrogenase; Validated; Region: PRK08507
251221001106	arogenate dehydrogenase; Reviewed; Region: PRK07417
251221001107	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
251221001108	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
251221001109	putative active site [active]
251221001110	oxyanion strand; other site
251221001111	catalytic triad [active]
251221001112	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
251221001113	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
251221001114	heme binding pocket [chemical binding]; other site
251221001115	heme ligand [chemical binding]; other site
251221001116	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
251221001117	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
251221001118	active site
251221001119	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
251221001120	rRNA binding site [nucleotide binding]; other site
251221001121	predicted 30S ribosome binding site; other site
251221001122	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
251221001123	S-layer homology domain; Region: SLH; pfam00395
251221001124	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
251221001125	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
251221001126	substrate binding pocket [chemical binding]; other site
251221001127	chain length determination region; other site
251221001128	active site lid residues [active]
251221001129	substrate-Mg2+ binding site; other site
251221001130	catalytic residues [active]
251221001131	aspartate-rich region 1; other site
251221001132	aspartate-rich region 2; other site
251221001133	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
251221001134	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221001135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221001136	dimer interface [polypeptide binding]; other site
251221001137	phosphorylation site [posttranslational modification]
251221001138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221001139	ATP binding site [chemical binding]; other site
251221001140	Mg2+ binding site [ion binding]; other site
251221001141	G-X-G motif; other site
251221001142	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
251221001143	dimerization interface [polypeptide binding]; other site
251221001144	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
251221001145	oxidoreductase; Provisional; Region: PRK07985
251221001146	NAD binding site [chemical binding]; other site
251221001147	metal binding site [ion binding]; metal-binding site
251221001148	active site
251221001149	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
251221001150	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
251221001151	active site
251221001152	catalytic residues [active]
251221001153	metal binding site [ion binding]; metal-binding site
251221001154	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
251221001155	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221001156	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
251221001157	active site
251221001158	ATP binding site [chemical binding]; other site
251221001159	substrate binding site [chemical binding]; other site
251221001160	activation loop (A-loop); other site
251221001161	Phage protein D [General function prediction only]; Region: COG3500
251221001162	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
251221001163	large tegument protein UL36; Provisional; Region: PHA03247
251221001164	large tegument protein UL36; Provisional; Region: PHA03247
251221001165	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949
251221001166	ribonuclease E; Reviewed; Region: rne; PRK10811
251221001167	ribonuclease E; Reviewed; Region: rne; PRK10811
251221001168	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
251221001169	conserved hypothetical phage tail region protein; Region: TIGR02241
251221001170	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
251221001171	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
251221001172	phosphopeptide binding site; other site
251221001173	Protein kinase domain; Region: Pkinase; pfam00069
251221001174	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
251221001175	active site
251221001176	substrate binding site [chemical binding]; other site
251221001177	ATP binding site [chemical binding]; other site
251221001178	activation loop (A-loop); other site
251221001179	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221001180	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
251221001181	phosphopeptide binding site; other site
251221001182	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
251221001183	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
251221001184	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
251221001185	dimer interface [polypeptide binding]; other site
251221001186	ssDNA binding site [nucleotide binding]; other site
251221001187	tetramer (dimer of dimers) interface [polypeptide binding]; other site
251221001188	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
251221001189	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
251221001190	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
251221001191	acyl-activating enzyme (AAE) consensus motif; other site
251221001192	putative AMP binding site [chemical binding]; other site
251221001193	putative active site [active]
251221001194	putative CoA binding site [chemical binding]; other site
251221001195	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
251221001196	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
251221001197	Walker A/P-loop; other site
251221001198	ATP binding site [chemical binding]; other site
251221001199	Q-loop/lid; other site
251221001200	ABC transporter signature motif; other site
251221001201	Walker B; other site
251221001202	D-loop; other site
251221001203	H-loop/switch region; other site
251221001204	Acyltransferase family; Region: Acyl_transf_3; cl19154
251221001205	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
251221001206	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
251221001207	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
251221001208	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
251221001209	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
251221001210	Substrate binding site; other site
251221001211	Mg++ binding site; other site
251221001212	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
251221001213	active site
251221001214	substrate binding site [chemical binding]; other site
251221001215	CoA binding site [chemical binding]; other site
251221001216	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
251221001217	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221001218	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
251221001219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221001220	dimer interface [polypeptide binding]; other site
251221001221	conserved gate region; other site
251221001222	putative PBP binding loops; other site
251221001223	ABC-ATPase subunit interface; other site
251221001224	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
251221001225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221001226	dimer interface [polypeptide binding]; other site
251221001227	conserved gate region; other site
251221001228	putative PBP binding loops; other site
251221001229	ABC-ATPase subunit interface; other site
251221001230	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
251221001231	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
251221001232	Walker A/P-loop; other site
251221001233	ATP binding site [chemical binding]; other site
251221001234	Q-loop/lid; other site
251221001235	ABC transporter signature motif; other site
251221001236	Walker B; other site
251221001237	D-loop; other site
251221001238	H-loop/switch region; other site
251221001239	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
251221001240	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
251221001241	active site
251221001242	Int/Topo IB signature motif; other site
251221001243	DNA binding site [nucleotide binding]
251221001244	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
251221001245	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
251221001246	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
251221001247	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
251221001248	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
251221001249	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221001250	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
251221001251	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
251221001252	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221001253	active site
251221001254	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
251221001255	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
251221001256	Bacterial sugar transferase; Region: Bac_transf; pfam02397
251221001257	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221001258	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221001259	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221001260	IPT/TIG domain; Region: TIG; pfam01833
251221001261	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
251221001262	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
251221001263	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221001264	Sulfotransferase domain; Region: Sulfotransfer_1; cl19239
251221001265	Sulfotransferase domain; Region: Sulfotransfer_1; cl19239
251221001266	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221001267	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
251221001268	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
251221001269	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
251221001270	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
251221001271	NAD binding site [chemical binding]; other site
251221001272	substrate binding site [chemical binding]; other site
251221001273	homodimer interface [polypeptide binding]; other site
251221001274	active site
251221001275	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
251221001276	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
251221001277	substrate binding site; other site
251221001278	tetramer interface; other site
251221001279	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
251221001280	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
251221001281	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
251221001282	active site
251221001283	Substrate binding site; other site
251221001284	Mg++ binding site; other site
251221001285	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221001286	putative trimer interface [polypeptide binding]; other site
251221001287	putative CoA binding site [chemical binding]; other site
251221001288	PAS domain; Region: PAS_9; pfam13426
251221001289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221001290	putative active site [active]
251221001291	heme pocket [chemical binding]; other site
251221001292	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
251221001293	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
251221001294	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221001295	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
251221001296	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
251221001297	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
251221001298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221001299	Walker A motif; other site
251221001300	ATP binding site [chemical binding]; other site
251221001301	Walker B motif; other site
251221001302	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
251221001303	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
251221001304	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
251221001305	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
251221001306	substrate binding pocket [chemical binding]; other site
251221001307	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
251221001308	B12 binding site [chemical binding]; other site
251221001309	cobalt ligand [ion binding]; other site
251221001310	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
251221001311	Uncharacterized conserved protein [Function unknown]; Region: COG5464
251221001312	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
251221001313	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221001314	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
251221001315	cyclase homology domain; Region: CHD; cd07302
251221001316	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
251221001317	nucleotidyl binding site; other site
251221001318	metal binding site [ion binding]; metal-binding site
251221001319	dimer interface [polypeptide binding]; other site
251221001320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001321	active site
251221001322	phosphorylation site [posttranslational modification]
251221001323	intermolecular recognition site; other site
251221001324	dimerization interface [polypeptide binding]; other site
251221001325	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
251221001326	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
251221001327	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
251221001328	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221001329	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221001330	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
251221001331	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
251221001332	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
251221001333	putative NAD(P) binding site [chemical binding]; other site
251221001334	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
251221001335	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221001336	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221001337	DevC protein; Region: devC; TIGR01185
251221001338	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221001339	FtsX-like permease family; Region: FtsX; pfam02687
251221001340	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
251221001341	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221001342	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221001343	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
251221001344	DNA-binding site [nucleotide binding]; DNA binding site
251221001345	RNA-binding motif; other site
251221001346	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
251221001347	PhoD-like phosphatase; Region: PhoD; pfam09423
251221001348	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
251221001349	putative active site [active]
251221001350	putative metal binding site [ion binding]; other site
251221001351	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585
251221001352	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
251221001353	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
251221001354	Walker A/P-loop; other site
251221001355	ATP binding site [chemical binding]; other site
251221001356	Q-loop/lid; other site
251221001357	ABC transporter signature motif; other site
251221001358	Walker B; other site
251221001359	D-loop; other site
251221001360	H-loop/switch region; other site
251221001361	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221001362	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
251221001363	FtsX-like permease family; Region: FtsX; pfam02687
251221001364	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
251221001365	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221001366	FtsX-like permease family; Region: FtsX; pfam02687
251221001367	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221001368	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
251221001369	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
251221001370	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221001371	Predicted methyltransferase [General function prediction only]; Region: COG4798
251221001372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221001373	Walker A motif; other site
251221001374	ATP binding site [chemical binding]; other site
251221001375	Walker B motif; other site
251221001376	arginine finger; other site
251221001377	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
251221001378	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
251221001379	Lamin Tail Domain; Region: LTD; pfam00932
251221001380	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
251221001381	generic binding surface II; other site
251221001382	generic binding surface I; other site
251221001383	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
251221001384	putative catalytic site [active]
251221001385	putative metal binding site [ion binding]; other site
251221001386	putative phosphate binding site [ion binding]; other site
251221001387	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221001388	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
251221001389	substrate binding site [chemical binding]; other site
251221001390	ATP binding site [chemical binding]; other site
251221001391	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
251221001392	putative substrate binding site [chemical binding]; other site
251221001393	putative ATP binding site [chemical binding]; other site
251221001394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221001395	S-adenosylmethionine binding site [chemical binding]; other site
251221001396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827
251221001397	Protein of unknown function (DUF445); Region: DUF445; pfam04286
251221001398	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221001399	putative active site [active]
251221001400	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
251221001401	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
251221001402	catalytic triad [active]
251221001403	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
251221001404	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027
251221001405	NIMA-related protein kinase; Provisional; Region: PTZ00266
251221001406	exopolyphosphatase; Region: exo_poly_only; TIGR03706
251221001407	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
251221001408	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
251221001409	Zn2+ binding site [ion binding]; other site
251221001410	Mg2+ binding site [ion binding]; other site
251221001411	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
251221001412	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
251221001413	ligand-binding site [chemical binding]; other site
251221001414	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
251221001415	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
251221001416	active site
251221001417	metal binding site [ion binding]; metal-binding site
251221001418	DNA binding site [nucleotide binding]
251221001419	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
251221001420	Cation transport protein; Region: TrkH; cl17365
251221001421	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
251221001422	Cation transport protein; Region: TrkH; cl17365
251221001423	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
251221001424	TrkA-N domain; Region: TrkA_N; pfam02254
251221001425	TrkA-C domain; Region: TrkA_C; pfam02080
251221001426	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221001427	putative active site [active]
251221001428	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
251221001429	Transposase, Mutator family; Region: Transposase_mut; cl19537
251221001430	Transposase, Mutator family; Region: Transposase_mut; cl19537
251221001431	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
251221001432	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
251221001433	Tetratricopeptide repeat; Region: TPR_6; pfam13174
251221001434	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
251221001435	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202
251221001436	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
251221001437	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
251221001438	N-acetyl-D-glucosamine binding site [chemical binding]; other site
251221001439	catalytic residue [active]
251221001440	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
251221001441	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
251221001442	active site
251221001443	metal binding site [ion binding]; metal-binding site
251221001444	prephenate dehydratase; Provisional; Region: PRK11898
251221001445	Prephenate dehydratase; Region: PDT; pfam00800
251221001446	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
251221001447	putative L-Phe binding site [chemical binding]; other site
251221001448	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
251221001449	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
251221001450	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
251221001451	aromatic acid decarboxylase; Validated; Region: PRK05920
251221001452	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
251221001453	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
251221001454	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
251221001455	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
251221001456	active site
251221001457	dimerization interface [polypeptide binding]; other site
251221001458	High-affinity nickel-transport protein; Region: NicO; cl00964
251221001459	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
251221001460	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
251221001461	P-loop, Walker A motif; other site
251221001462	Base recognition motif; other site
251221001463	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
251221001464	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221001465	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221001466	structural tetrad; other site
251221001467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221001468	S-adenosylmethionine binding site [chemical binding]; other site
251221001469	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
251221001470	putative active site [active]
251221001471	catalytic residue [active]
251221001472	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
251221001473	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
251221001474	substrate binding pocket [chemical binding]; other site
251221001475	dimer interface [polypeptide binding]; other site
251221001476	inhibitor binding site; inhibition site
251221001477	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
251221001478	PRC-barrel domain; Region: PRC; pfam05239
251221001479	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
251221001480	hypothetical protein; Provisional; Region: PRK04194
251221001481	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
251221001482	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
251221001483	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
251221001484	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
251221001485	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
251221001486	inhibitor-cofactor binding pocket; inhibition site
251221001487	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221001488	catalytic residue [active]
251221001489	Helix-turn-helix domain; Region: HTH_18; pfam12833
251221001490	Dienelactone hydrolase family; Region: DLH; pfam01738
251221001491	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
251221001492	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221001493	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
251221001494	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
251221001495	Ligand Binding Site [chemical binding]; other site
251221001496	Anti-sigma-K factor rskA; Region: RskA; pfam10099
251221001497	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
251221001498	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
251221001499	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
251221001500	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
251221001501	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
251221001502	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
251221001503	Protein of unknown function (DUF642); Region: DUF642; cl19911
251221001504	FOG: PKD repeat [General function prediction only]; Region: COG3291
251221001505	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
251221001506	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
251221001507	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
251221001508	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
251221001509	purine monophosphate binding site [chemical binding]; other site
251221001510	dimer interface [polypeptide binding]; other site
251221001511	putative catalytic residues [active]
251221001512	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
251221001513	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
251221001514	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
251221001515	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
251221001516	mercuric reductase; Validated; Region: PRK06370
251221001517	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221001518	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
251221001519	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
251221001520	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
251221001521	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
251221001522	Chromate transporter; Region: Chromate_transp; pfam02417
251221001523	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
251221001524	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
251221001525	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058
251221001526	active site
251221001527	dimer interface [polypeptide binding]; other site
251221001528	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
251221001529	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
251221001530	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
251221001531	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
251221001532	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
251221001533	Ligand Binding Site [chemical binding]; other site
251221001534	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
251221001535	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
251221001536	Ligand Binding Site [chemical binding]; other site
251221001537	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221001538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001539	active site
251221001540	phosphorylation site [posttranslational modification]
251221001541	intermolecular recognition site; other site
251221001542	dimerization interface [polypeptide binding]; other site
251221001543	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221001544	DNA binding residues [nucleotide binding]
251221001545	dimerization interface [polypeptide binding]; other site
251221001546	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221001547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221001548	dimer interface [polypeptide binding]; other site
251221001549	phosphorylation site [posttranslational modification]
251221001550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221001551	ATP binding site [chemical binding]; other site
251221001552	Mg2+ binding site [ion binding]; other site
251221001553	G-X-G motif; other site
251221001554	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
251221001555	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
251221001556	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
251221001557	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
251221001558	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
251221001559	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221001560	putative active site [active]
251221001561	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
251221001562	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
251221001563	Walker A/P-loop; other site
251221001564	ATP binding site [chemical binding]; other site
251221001565	Q-loop/lid; other site
251221001566	ABC transporter signature motif; other site
251221001567	Walker B; other site
251221001568	D-loop; other site
251221001569	H-loop/switch region; other site
251221001570	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
251221001571	ABC-ATPase subunit  interface; other site
251221001572	dimer interface [polypeptide binding]; other site
251221001573	putative PBP binding regions; other site
251221001574	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
251221001575	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
251221001576	putative hemin binding site; other site
251221001577	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
251221001578	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221001579	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221001580	putative active site [active]
251221001581	Protein of unknown function; Region: DUF3971; pfam13116
251221001582	Protein of unknown function (DUF1345); Region: DUF1345; cl01753
251221001583	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221001584	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221001585	active site
251221001586	ATP binding site [chemical binding]; other site
251221001587	substrate binding site [chemical binding]; other site
251221001588	activation loop (A-loop); other site
251221001589	Predicted integral membrane protein [Function unknown]; Region: COG5616
251221001590	TPR repeat; Region: TPR_11; pfam13414
251221001591	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221001592	binding surface
251221001593	TPR motif; other site
251221001594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221001595	binding surface
251221001596	TPR motif; other site
251221001597	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
251221001598	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
251221001599	Probable transposase; Region: OrfB_IS605; pfam01385
251221001600	conserved hypothetical protein; Region: nitr_red_assoc; TIGR02664
251221001601	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
251221001602	active site
251221001603	metal binding site [ion binding]; metal-binding site
251221001604	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
251221001605	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
251221001606	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
251221001607	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
251221001608	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
251221001609	hypothetical protein; Validated; Region: PRK00029
251221001610	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
251221001611	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
251221001612	AAA domain; Region: AAA_17; pfam13207
251221001613	ABC transporter; Region: ABC_tran_2; pfam12848
251221001614	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
251221001615	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
251221001616	ABC transporter; Region: ABC_tran_2; pfam12848
251221001617	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
251221001618	MgtC family; Region: MgtC; pfam02308
251221001619	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
251221001620	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
251221001621	dinuclear metal binding motif [ion binding]; other site
251221001622	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221001623	putative active site [active]
251221001624	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221001625	TPR motif; other site
251221001626	binding surface
251221001627	TPR repeat; Region: TPR_11; pfam13414
251221001628	Transposase domain (DUF772); Region: DUF772; pfam05598
251221001629	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
251221001630	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
251221001631	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
251221001632	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
251221001633	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
251221001634	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708
251221001635	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
251221001636	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
251221001637	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
251221001638	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
251221001639	AAA-like domain; Region: AAA_10; pfam12846
251221001640	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
251221001641	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
251221001642	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
251221001643	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221001644	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
251221001645	protein binding site [polypeptide binding]; other site
251221001646	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
251221001647	protein binding site [polypeptide binding]; other site
251221001648	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
251221001649	Uncharacterized conserved protein [Function unknown]; Region: COG0432
251221001650	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
251221001651	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
251221001652	Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490
251221001653	AAA domain; Region: AAA_30; pfam13604
251221001654	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
251221001655	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
251221001656	PemK-like protein; Region: PemK; pfam02452
251221001657	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
251221001658	putative active site [active]
251221001659	homotetrameric interface [polypeptide binding]; other site
251221001660	metal binding site [ion binding]; metal-binding site
251221001661	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
251221001662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001663	active site
251221001664	phosphorylation site [posttranslational modification]
251221001665	intermolecular recognition site; other site
251221001666	dimerization interface [polypeptide binding]; other site
251221001667	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
251221001668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221001669	putative active site [active]
251221001670	heme pocket [chemical binding]; other site
251221001671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221001672	dimer interface [polypeptide binding]; other site
251221001673	phosphorylation site [posttranslational modification]
251221001674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221001675	ATP binding site [chemical binding]; other site
251221001676	Mg2+ binding site [ion binding]; other site
251221001677	G-X-G motif; other site
251221001678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001679	active site
251221001680	phosphorylation site [posttranslational modification]
251221001681	intermolecular recognition site; other site
251221001682	dimerization interface [polypeptide binding]; other site
251221001683	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
251221001684	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221001685	dimerization interface [polypeptide binding]; other site
251221001686	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221001687	dimerization interface [polypeptide binding]; other site
251221001688	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221001689	dimerization interface [polypeptide binding]; other site
251221001690	GAF domain; Region: GAF_2; pfam13185
251221001691	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
251221001692	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
251221001693	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221001694	dimer interface [polypeptide binding]; other site
251221001695	phosphorylation site [posttranslational modification]
251221001696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221001697	ATP binding site [chemical binding]; other site
251221001698	Mg2+ binding site [ion binding]; other site
251221001699	G-X-G motif; other site
251221001700	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221001701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001702	active site
251221001703	phosphorylation site [posttranslational modification]
251221001704	intermolecular recognition site; other site
251221001705	dimerization interface [polypeptide binding]; other site
251221001706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001707	active site
251221001708	phosphorylation site [posttranslational modification]
251221001709	intermolecular recognition site; other site
251221001710	dimerization interface [polypeptide binding]; other site
251221001711	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221001712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001713	active site
251221001714	phosphorylation site [posttranslational modification]
251221001715	intermolecular recognition site; other site
251221001716	dimerization interface [polypeptide binding]; other site
251221001717	DNA polymerase I; Provisional; Region: PRK05755
251221001718	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
251221001719	active site
251221001720	metal binding site 1 [ion binding]; metal-binding site
251221001721	putative 5' ssDNA interaction site; other site
251221001722	metal binding site 3; metal-binding site
251221001723	metal binding site 2 [ion binding]; metal-binding site
251221001724	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
251221001725	putative DNA binding site [nucleotide binding]; other site
251221001726	putative metal binding site [ion binding]; other site
251221001727	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
251221001728	active site
251221001729	catalytic site [active]
251221001730	substrate binding site [chemical binding]; other site
251221001731	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
251221001732	active site
251221001733	DNA binding site [nucleotide binding]
251221001734	catalytic site [active]
251221001735	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
251221001736	S-layer homology domain; Region: SLH; pfam00395
251221001737	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
251221001738	formamidopyrimidine-DNA glycosylase (fpg); Region: fpg; TIGR00577
251221001739	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
251221001740	Sulfatase; Region: Sulfatase; pfam00884
251221001741	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221001742	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221001743	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221001744	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221001745	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221001746	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
251221001747	Sulfatase; Region: Sulfatase; pfam00884
251221001748	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
251221001749	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
251221001750	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
251221001751	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221001752	Walker A/P-loop; other site
251221001753	ATP binding site [chemical binding]; other site
251221001754	Q-loop/lid; other site
251221001755	ABC transporter signature motif; other site
251221001756	Walker B; other site
251221001757	D-loop; other site
251221001758	H-loop/switch region; other site
251221001759	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
251221001760	NADH dehydrogenase subunit 4L; Region: ndhE; CHL00015
251221001761	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
251221001762	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
251221001763	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
251221001764	Protease prsW family; Region: PrsW-protease; pfam13367
251221001765	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
251221001766	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
251221001767	minor groove reading motif; other site
251221001768	helix-hairpin-helix signature motif; other site
251221001769	substrate binding pocket [chemical binding]; other site
251221001770	active site
251221001771	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221001772	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221001773	active site
251221001774	ATP binding site [chemical binding]; other site
251221001775	substrate binding site [chemical binding]; other site
251221001776	activation loop (A-loop); other site
251221001777	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
251221001778	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
251221001779	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221001780	dimerization interface [polypeptide binding]; other site
251221001781	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
251221001782	membrane protein; Provisional; Region: PRK14419
251221001783	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
251221001784	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221001785	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221001786	active site
251221001787	ATP binding site [chemical binding]; other site
251221001788	substrate binding site [chemical binding]; other site
251221001789	activation loop (A-loop); other site
251221001790	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
251221001791	MPT binding site; other site
251221001792	trimer interface [polypeptide binding]; other site
251221001793	tellurium resistance terB-like protein; Region: terB_like; cd07177
251221001794	metal binding site [ion binding]; metal-binding site
251221001795	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
251221001796	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
251221001797	Probable Catalytic site; other site
251221001798	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
251221001799	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221001800	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
251221001801	DNA binding residues [nucleotide binding]
251221001802	SnoaL-like domain; Region: SnoaL_2; pfam12680
251221001803	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
251221001804	Uncharacterized conserved protein [Function unknown]; Region: COG2128
251221001805	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221001806	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221001807	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221001808	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221001809	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221001810	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221001811	ABC-2 type transporter; Region: ABC2_membrane; cl17235
251221001812	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
251221001813	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
251221001814	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
251221001815	Walker A/P-loop; other site
251221001816	ATP binding site [chemical binding]; other site
251221001817	Q-loop/lid; other site
251221001818	ABC transporter signature motif; other site
251221001819	Walker B; other site
251221001820	D-loop; other site
251221001821	H-loop/switch region; other site
251221001822	thymidylate kinase; Validated; Region: tmk; PRK00698
251221001823	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
251221001824	TMP-binding site; other site
251221001825	ATP-binding site [chemical binding]; other site
251221001826	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
251221001827	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
251221001828	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
251221001829	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221001830	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
251221001831	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
251221001832	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
251221001833	Protein of unknown function DUF72; Region: DUF72; pfam01904
251221001834	CAAX protease self-immunity; Region: Abi; cl00558
251221001835	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221001836	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
251221001837	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
251221001838	homodimer interface [polypeptide binding]; other site
251221001839	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
251221001840	active site pocket [active]
251221001841	Nitrogen regulatory protein P-II; Region: P-II; smart00938
251221001842	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221001843	Ligand Binding Site [chemical binding]; other site
251221001844	BolA-like protein; Region: BolA; pfam01722
251221001845	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
251221001846	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221001847	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
251221001848	homodimer interface [polypeptide binding]; other site
251221001849	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
251221001850	active site pocket [active]
251221001851	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221001852	putative active site [active]
251221001853	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
251221001854	Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673
251221001855	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
251221001856	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
251221001857	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
251221001858	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
251221001859	Ligand binding site; other site
251221001860	Putative Catalytic site; other site
251221001861	DXD motif; other site
251221001862	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
251221001863	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
251221001864	active site
251221001865	homodimer interface [polypeptide binding]; other site
251221001866	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
251221001867	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
251221001868	catalytic residue [active]
251221001869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
251221001870	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
251221001871	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
251221001872	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
251221001873	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
251221001874	catalytic motif [active]
251221001875	Catalytic residue [active]
251221001876	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
251221001877	catalytic residues [active]
251221001878	TonB C terminal; Region: TonB_2; pfam13103
251221001879	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
251221001880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221001881	S-adenosylmethionine binding site [chemical binding]; other site
251221001882	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
251221001883	DNA-binding site [nucleotide binding]; DNA binding site
251221001884	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
251221001885	Catalytic site [active]
251221001886	Nucleoside diphosphate kinase; Region: NDK; pfam00334
251221001887	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
251221001888	active site
251221001889	multimer interface [polypeptide binding]; other site
251221001890	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
251221001891	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
251221001892	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
251221001893	dimer interface [polypeptide binding]; other site
251221001894	ligand binding site [chemical binding]; other site
251221001895	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221001896	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221001897	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
251221001898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221001899	binding surface
251221001900	TPR motif; other site
251221001901	seryl-tRNA synthetase; Provisional; Region: PRK05431
251221001902	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
251221001903	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
251221001904	dimer interface [polypeptide binding]; other site
251221001905	active site
251221001906	motif 1; other site
251221001907	motif 2; other site
251221001908	motif 3; other site
251221001909	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
251221001910	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221001911	motif II; other site
251221001912	PAS domain S-box; Region: sensory_box; TIGR00229
251221001913	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
251221001914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221001915	dimer interface [polypeptide binding]; other site
251221001916	phosphorylation site [posttranslational modification]
251221001917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221001918	ATP binding site [chemical binding]; other site
251221001919	Mg2+ binding site [ion binding]; other site
251221001920	G-X-G motif; other site
251221001921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221001922	active site
251221001923	phosphorylation site [posttranslational modification]
251221001924	intermolecular recognition site; other site
251221001925	dimerization interface [polypeptide binding]; other site
251221001926	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221001927	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
251221001928	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
251221001929	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
251221001930	dimerization interface [polypeptide binding]; other site
251221001931	putative ATP binding site [chemical binding]; other site
251221001932	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
251221001933	putative active site [active]
251221001934	homotetrameric interface [polypeptide binding]; other site
251221001935	metal binding site [ion binding]; metal-binding site
251221001936	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
251221001937	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
251221001938	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
251221001939	DNA binding residues [nucleotide binding]
251221001940	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
251221001941	Caspase domain; Region: Peptidase_C14; pfam00656
251221001942	AAA ATPase domain; Region: AAA_16; pfam13191
251221001943	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221001944	WD domain, G-beta repeat; Region: WD40; pfam00400
251221001945	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221001946	structural tetrad; other site
251221001947	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221001948	structural tetrad; other site
251221001949	WD domain, G-beta repeat; Region: WD40; pfam00400
251221001950	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221001951	putative active site [active]
251221001952	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
251221001953	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
251221001954	nucleotide binding pocket [chemical binding]; other site
251221001955	K-X-D-G motif; other site
251221001956	catalytic site [active]
251221001957	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
251221001958	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
251221001959	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
251221001960	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
251221001961	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
251221001962	Dimer interface [polypeptide binding]; other site
251221001963	BRCT sequence motif; other site
251221001964	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
251221001965	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
251221001966	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
251221001967	Zn binding site [ion binding]; other site
251221001968	ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838
251221001969	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
251221001970	active site
251221001971	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
251221001972	GIY-YIG motif/motif A; other site
251221001973	putative active site [active]
251221001974	putative metal binding site [ion binding]; other site
251221001975	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
251221001976	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
251221001977	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
251221001978	NAD binding site [chemical binding]; other site
251221001979	catalytic Zn binding site [ion binding]; other site
251221001980	structural Zn binding site [ion binding]; other site
251221001981	Predicted integral membrane protein [Function unknown]; Region: COG5637
251221001982	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
251221001983	putative hydrophobic ligand binding site [chemical binding]; other site
251221001984	Predicted membrane protein [Function unknown]; Region: COG4244
251221001985	Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990
251221001986	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
251221001987	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
251221001988	Uncharacterized subfamily with similarity to Heme-copper oxidase subunit II cupredoxin domain; Region: CuRO_HCO_II_like_5; cd13919
251221001989	CuA binuclear center [ion binding]; other site
251221001990	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
251221001991	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
251221001992	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
251221001993	short chain dehydrogenase; Provisional; Region: PRK07109
251221001994	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
251221001995	putative NAD(P) binding site [chemical binding]; other site
251221001996	active site
251221001997	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221001998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
251221001999	active site
251221002000	phosphorylation site [posttranslational modification]
251221002001	intermolecular recognition site; other site
251221002002	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
251221002003	DNA binding residues [nucleotide binding]
251221002004	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
251221002005	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
251221002006	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
251221002007	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
251221002008	homotrimer interface [polypeptide binding]; other site
251221002009	Walker A motif; other site
251221002010	GTP binding site [chemical binding]; other site
251221002011	Walker B motif; other site
251221002012	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
251221002013	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
251221002014	NADH dehydrogenase subunit B; Validated; Region: PRK06411
251221002015	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
251221002016	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
251221002017	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
251221002018	intersubunit interface [polypeptide binding]; other site
251221002019	active site
251221002020	zinc binding site [ion binding]; other site
251221002021	Na+ binding site [ion binding]; other site
251221002022	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
251221002023	substrate binding pocket [chemical binding]; other site
251221002024	chain length determination region; other site
251221002025	substrate-Mg2+ binding site; other site
251221002026	catalytic residues [active]
251221002027	aspartate-rich region 1; other site
251221002028	active site lid residues [active]
251221002029	aspartate-rich region 2; other site
251221002030	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
251221002031	active site
251221002032	Stage II sporulation protein; Region: SpoIID; pfam08486
251221002033	phosphoglyceromutase; Provisional; Region: PRK05434
251221002034	anthranilate synthase component I-like protein; Validated; Region: PRK05940
251221002035	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
251221002036	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
251221002037	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
251221002038	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_3; cd06240
251221002039	putative active site [active]
251221002040	Zn binding site [ion binding]; other site
251221002041	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221002042	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
251221002043	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
251221002044	oligomerization interface [polypeptide binding]; other site
251221002045	active site
251221002046	metal binding site [ion binding]; metal-binding site
251221002047	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
251221002048	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
251221002049	NADP-binding site; other site
251221002050	homotetramer interface [polypeptide binding]; other site
251221002051	substrate binding site [chemical binding]; other site
251221002052	homodimer interface [polypeptide binding]; other site
251221002053	active site
251221002054	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
251221002055	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
251221002056	NADP-binding site; other site
251221002057	homotetramer interface [polypeptide binding]; other site
251221002058	substrate binding site [chemical binding]; other site
251221002059	homodimer interface [polypeptide binding]; other site
251221002060	active site
251221002061	cysteine synthase; Region: PLN02565
251221002062	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
251221002063	dimer interface [polypeptide binding]; other site
251221002064	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221002065	catalytic residue [active]
251221002066	Peptidase family M48; Region: Peptidase_M48; cl12018
251221002067	Penicillinase repressor; Region: Penicillinase_R; pfam03965
251221002068	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221002069	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
251221002070	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
251221002071	putative active site pocket [active]
251221002072	4-fold oligomerization interface [polypeptide binding]; other site
251221002073	metal binding residues [ion binding]; metal-binding site
251221002074	3-fold/trimer interface [polypeptide binding]; other site
251221002075	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
251221002076	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
251221002077	phosphopeptide binding site; other site
251221002078	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
251221002079	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
251221002080	catalytic core [active]
251221002081	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
251221002082	catalytic core [active]
251221002083	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221002084	binding surface
251221002085	TPR motif; other site
251221002086	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221002087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221002088	active site
251221002089	phosphorylation site [posttranslational modification]
251221002090	intermolecular recognition site; other site
251221002091	dimerization interface [polypeptide binding]; other site
251221002092	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221002093	DNA binding residues [nucleotide binding]
251221002094	dimerization interface [polypeptide binding]; other site
251221002095	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221002096	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
251221002097	FtsX-like permease family; Region: FtsX; pfam02687
251221002098	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221002099	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221002100	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221002101	putative membrane fusion protein; Region: TIGR02828
251221002102	FO synthase subunit 2; Reviewed; Region: PRK07360
251221002103	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221002104	FeS/SAM binding site; other site
251221002105	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
251221002106	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221002107	active site
251221002108	motif I; other site
251221002109	motif II; other site
251221002110	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
251221002111	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
251221002112	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
251221002113	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221002114	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
251221002115	pheophytin binding site; other site
251221002116	chlorophyll binding site; other site
251221002117	quinone binding site; other site
251221002118	Fe binding site [ion binding]; other site
251221002119	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
251221002120	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
251221002121	nucleotide binding site [chemical binding]; other site
251221002122	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
251221002123	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
251221002124	metal binding site 2 [ion binding]; metal-binding site
251221002125	putative DNA binding helix; other site
251221002126	metal binding site 1 [ion binding]; metal-binding site
251221002127	dimer interface [polypeptide binding]; other site
251221002128	structural Zn2+ binding site [ion binding]; other site
251221002129	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
251221002130	DNA photolyase; Region: DNA_photolyase; pfam00875
251221002131	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
251221002132	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
251221002133	Domain of unknown function DUF21; Region: DUF21; pfam01595
251221002134	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
251221002135	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
251221002136	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
251221002137	30S subunit binding site; other site
251221002138	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
251221002139	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
251221002140	Zn2+ binding site [ion binding]; other site
251221002141	Mg2+ binding site [ion binding]; other site
251221002142	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
251221002143	FAD binding site [chemical binding]; other site
251221002144	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
251221002145	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
251221002146	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221002147	adenosine kinase; Provisional; Region: PTZ00247
251221002148	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
251221002149	substrate binding site [chemical binding]; other site
251221002150	ATP binding site [chemical binding]; other site
251221002151	ribosomal protein L32; Validated; Region: rpl32; CHL00152
251221002152	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
251221002153	NHL repeat; Region: NHL; pfam01436
251221002154	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221002155	Probable pheophorbidase; Region: PLN02965; cl17657
251221002156	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221002157	Rrf2 family protein; Region: rrf2_super; TIGR00738
251221002158	Predicted transcriptional regulator [Transcription]; Region: COG1959
251221002159	cysteine synthase; Region: PLN02565
251221002160	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
251221002161	dimer interface [polypeptide binding]; other site
251221002162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221002163	catalytic residue [active]
251221002164	putative phosphate acyltransferase; Provisional; Region: PRK05331
251221002165	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
251221002166	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
251221002167	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221002168	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221002169	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221002170	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221002171	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221002172	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
251221002173	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322
251221002174	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
251221002175	putative ligand binding site [chemical binding]; other site
251221002176	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
251221002177	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
251221002178	Walker A/P-loop; other site
251221002179	ATP binding site [chemical binding]; other site
251221002180	Q-loop/lid; other site
251221002181	ABC transporter signature motif; other site
251221002182	Walker B; other site
251221002183	D-loop; other site
251221002184	H-loop/switch region; other site
251221002185	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
251221002186	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
251221002187	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
251221002188	B12 binding site [chemical binding]; other site
251221002189	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221002190	FeS/SAM binding site; other site
251221002191	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
251221002192	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
251221002193	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
251221002194	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
251221002195	Ligand Binding Site [chemical binding]; other site
251221002196	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221002197	Ligand Binding Site [chemical binding]; other site
251221002198	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221002199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221002200	active site
251221002201	phosphorylation site [posttranslational modification]
251221002202	intermolecular recognition site; other site
251221002203	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221002204	DNA binding residues [nucleotide binding]
251221002205	dimerization interface [polypeptide binding]; other site
251221002206	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
251221002207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221002208	dimer interface [polypeptide binding]; other site
251221002209	phosphorylation site [posttranslational modification]
251221002210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221002211	ATP binding site [chemical binding]; other site
251221002212	Mg2+ binding site [ion binding]; other site
251221002213	G-X-G motif; other site
251221002214	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
251221002215	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
251221002216	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
251221002217	tellurium resistance terB-like protein; Region: terB_like; cd07177
251221002218	metal binding site [ion binding]; metal-binding site
251221002219	Protein of unknown function DUF262; Region: DUF262; pfam03235
251221002220	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
251221002221	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
251221002222	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
251221002223	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
251221002224	O-Antigen ligase; Region: Wzy_C; pfam04932
251221002225	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
251221002226	DHH family; Region: DHH; pfam01368
251221002227	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
251221002228	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
251221002229	Zn binding site [ion binding]; other site
251221002230	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221002231	putative active site [active]
251221002232	Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870
251221002233	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
251221002234	Asp-box motif; other site
251221002235	Ribosomal protein L12E/L44/L45/RPP1/RPP2 [Translation, ribosomal structure and biogenesis]; Region: RPP1A; COG2058
251221002236	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
251221002237	ribosomal protein L21; Region: rpl21; CHL00075
251221002238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
251221002239	FIST N domain; Region: FIST; pfam08495
251221002240	FIST C domain; Region: FIST_C; pfam10442
251221002241	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221002242	active site
251221002243	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
251221002244	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
251221002245	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
251221002246	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
251221002247	putative homodimer interface [polypeptide binding]; other site
251221002248	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
251221002249	heterodimer interface [polypeptide binding]; other site
251221002250	homodimer interface [polypeptide binding]; other site
251221002251	protein translocase, SecG subunit; Region: secG; TIGR00810
251221002252	histone-like DNA-binding protein HU; Region: HU; cd13831
251221002253	dimer interface [polypeptide binding]; other site
251221002254	DNA binding site [nucleotide binding]
251221002255	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
251221002256	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221002257	active site
251221002258	motif I; other site
251221002259	motif II; other site
251221002260	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
251221002261	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
251221002262	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221002263	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
251221002264	DNA photolyase; Region: DNA_photolyase; pfam00875
251221002265	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
251221002266	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221002267	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
251221002268	active site
251221002269	catalytic tetrad [active]
251221002270	ferrochelatase; Reviewed; Region: hemH; PRK00035
251221002271	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
251221002272	C-terminal domain interface [polypeptide binding]; other site
251221002273	active site
251221002274	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
251221002275	active site
251221002276	N-terminal domain interface [polypeptide binding]; other site
251221002277	Dihaem cytochrome c; Region: DHC; pfam09626
251221002278	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
251221002279	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
251221002280	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
251221002281	putative hydrophobic ligand binding site [chemical binding]; other site
251221002282	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
251221002283	oligomeric interface; other site
251221002284	putative active site [active]
251221002285	homodimer interface [polypeptide binding]; other site
251221002286	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
251221002287	L-aspartate oxidase; Provisional; Region: PRK07395
251221002288	L-aspartate oxidase; Provisional; Region: PRK06175
251221002289	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
251221002290	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
251221002291	active site
251221002292	(T/H)XGH motif; other site
251221002293	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
251221002294	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
251221002295	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
251221002296	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
251221002297	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
251221002298	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
251221002299	active site
251221002300	HIGH motif; other site
251221002301	KMSKS motif; other site
251221002302	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
251221002303	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
251221002304	Rubredoxin [Energy production and conversion]; Region: COG1773
251221002305	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
251221002306	iron binding site [ion binding]; other site
251221002307	Ycf48-like protein; Provisional; Region: PRK13684
251221002308	Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870
251221002309	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
251221002310	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834
251221002311	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
251221002312	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
251221002313	PsbL protein; Region: PsbL; pfam02419
251221002314	photosystem II reaction center protein J; Provisional; Region: PRK02565
251221002315	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221002316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221002317	active site
251221002318	phosphorylation site [posttranslational modification]
251221002319	intermolecular recognition site; other site
251221002320	dimerization interface [polypeptide binding]; other site
251221002321	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221002322	DNA binding site [nucleotide binding]
251221002323	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221002324	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221002325	dimerization interface [polypeptide binding]; other site
251221002326	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221002327	dimer interface [polypeptide binding]; other site
251221002328	phosphorylation site [posttranslational modification]
251221002329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221002330	ATP binding site [chemical binding]; other site
251221002331	Mg2+ binding site [ion binding]; other site
251221002332	G-X-G motif; other site
251221002333	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
251221002334	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
251221002335	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
251221002336	Domain of unknown function (DUF305); Region: DUF305; cl17794
251221002337	A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754
251221002338	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
251221002339	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
251221002340	minor groove reading motif; other site
251221002341	helix-hairpin-helix signature motif; other site
251221002342	substrate binding pocket [chemical binding]; other site
251221002343	active site
251221002344	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
251221002345	DNA binding and oxoG recognition site [nucleotide binding]
251221002346	phytoene desaturase; Region: crtI_fam; TIGR02734
251221002347	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221002348	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221002349	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
251221002350	active site
251221002351	8-oxo-dGMP binding site [chemical binding]; other site
251221002352	nudix motif; other site
251221002353	metal binding site [ion binding]; metal-binding site
251221002354	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
251221002355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221002356	Walker A motif; other site
251221002357	ATP binding site [chemical binding]; other site
251221002358	Walker B motif; other site
251221002359	arginine finger; other site
251221002360	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
251221002361	metal ion-dependent adhesion site (MIDAS); other site
251221002362	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221002363	putative active site [active]
251221002364	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221002365	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
251221002366	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
251221002367	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221002368	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
251221002369	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221002370	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
251221002371	MMPL family; Region: MMPL; cl14618
251221002372	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
251221002373	dimerization interface [polypeptide binding]; other site
251221002374	putative DNA binding site [nucleotide binding]; other site
251221002375	putative Zn2+ binding site [ion binding]; other site
251221002376	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
251221002377	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
251221002378	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
251221002379	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
251221002380	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
251221002381	active site
251221002382	catalytic residues [active]
251221002383	metal binding site [ion binding]; metal-binding site
251221002384	homodimer binding site [polypeptide binding]; other site
251221002385	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
251221002386	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
251221002387	catalytic residues [active]
251221002388	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
251221002389	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
251221002390	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
251221002391	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
251221002392	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
251221002393	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
251221002394	glutamine binding [chemical binding]; other site
251221002395	catalytic triad [active]
251221002396	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
251221002397	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
251221002398	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
251221002399	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
251221002400	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
251221002401	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221002402	FeS/SAM binding site; other site
251221002403	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
251221002404	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
251221002405	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
251221002406	dimerization interface [polypeptide binding]; other site
251221002407	active site
251221002408	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
251221002409	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
251221002410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221002411	dimer interface [polypeptide binding]; other site
251221002412	conserved gate region; other site
251221002413	putative PBP binding loops; other site
251221002414	ABC-ATPase subunit interface; other site
251221002415	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002416	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002417	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221002418	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
251221002419	SdiA-regulated; Region: SdiA-regulated; cl19046
251221002420	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
251221002421	putative active site [active]
251221002422	putative transposase OrfB; Reviewed; Region: PHA02517
251221002423	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002424	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002425	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221002426	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221002427	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221002428	N-terminal plug; other site
251221002429	ligand-binding site [chemical binding]; other site
251221002430	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
251221002431	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
251221002432	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
251221002433	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
251221002434	active site
251221002435	Integral membrane protein DUF92; Region: DUF92; pfam01940
251221002436	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
251221002437	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
251221002438	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221002439	active site
251221002440	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
251221002441	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
251221002442	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
251221002443	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
251221002444	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221002445	structural tetrad; other site
251221002446	PQQ-like domain; Region: PQQ_2; pfam13360
251221002447	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
251221002448	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
251221002449	conserved cys residue [active]
251221002450	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221002451	putative active site [active]
251221002452	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
251221002453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
251221002454	benzoate transport; Region: 2A0115; TIGR00895
251221002455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221002456	putative substrate translocation pore; other site
251221002457	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
251221002458	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221002459	Coenzyme A binding pocket [chemical binding]; other site
251221002460	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221002461	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221002462	active site
251221002463	ATP binding site [chemical binding]; other site
251221002464	substrate binding site [chemical binding]; other site
251221002465	activation loop (A-loop); other site
251221002466	Predicted integral membrane protein [Function unknown]; Region: COG5616
251221002467	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
251221002468	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
251221002469	Secretin and TonB N terminus short domain; Region: STN; smart00965
251221002470	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
251221002471	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
251221002472	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
251221002473	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
251221002474	Walker A motif; other site
251221002475	ATP binding site [chemical binding]; other site
251221002476	Walker B motif; other site
251221002477	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221002478	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221002479	ligand binding site [chemical binding]; other site
251221002480	flexible hinge region; other site
251221002481	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
251221002482	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221002483	Walker A motif; other site
251221002484	ATP binding site [chemical binding]; other site
251221002485	Walker B motif; other site
251221002486	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
251221002487	4Fe-4S binding domain; Region: Fer4_5; pfam12801
251221002488	4Fe-4S binding domain; Region: Fer4_5; pfam12801
251221002489	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
251221002490	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
251221002491	putative active site [active]
251221002492	Nudix N-terminal; Region: Nudix_N_2; pfam14803
251221002493	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
251221002494	nudix motif; other site
251221002495	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
251221002496	aromatic arch; other site
251221002497	DCoH dimer interaction site [polypeptide binding]; other site
251221002498	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
251221002499	DCoH tetramer interaction site [polypeptide binding]; other site
251221002500	substrate binding site [chemical binding]; other site
251221002501	photosystem II reaction center protein Psb28; Region: PS_II_psb28; TIGR03047
251221002502	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
251221002503	nucleotide binding site/active site [active]
251221002504	HIT family signature motif; other site
251221002505	catalytic residue [active]
251221002506	Uncharacterized conserved protein [Function unknown]; Region: COG2006
251221002507	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
251221002508	glycogen synthase; Provisional; Region: glgA; PRK00654
251221002509	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
251221002510	ADP-binding pocket [chemical binding]; other site
251221002511	homodimer interface [polypeptide binding]; other site
251221002512	Ion channel; Region: Ion_trans_2; pfam07885
251221002513	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
251221002514	TrkA-N domain; Region: TrkA_N; pfam02254
251221002515	TrkA-C domain; Region: TrkA_C; pfam02080
251221002516	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221002517	Amidohydrolase; Region: Amidohydro_4; pfam13147
251221002518	active site
251221002519	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
251221002520	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
251221002521	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
251221002522	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221002523	putative active site [active]
251221002524	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
251221002525	Mechanosensitive ion channel; Region: MS_channel; pfam00924
251221002526	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
251221002527	Collagenase; Region: DUF3656; pfam12392
251221002528	Peptidase family U32; Region: Peptidase_U32; cl03113
251221002529	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
251221002530	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
251221002531	putative NAD(P) binding site [chemical binding]; other site
251221002532	catalytic Zn binding site [ion binding]; other site
251221002533	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
251221002534	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
251221002535	protoporphyrinogen oxidase; Region: PLN02576
251221002536	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
251221002537	Chorismate lyase; Region: Chor_lyase; cl01230
251221002538	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
251221002539	active site clefts [active]
251221002540	zinc binding site [ion binding]; other site
251221002541	dimer interface [polypeptide binding]; other site
251221002542	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
251221002543	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
251221002544	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
251221002545	peptide binding site [polypeptide binding]; other site
251221002546	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221002547	Protein of unknown function (DUF2656); Region: DUF2656; pfam10847
251221002548	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
251221002549	putative dimer interface [polypeptide binding]; other site
251221002550	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002551	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002552	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
251221002553	active site
251221002554	catalytic triad [active]
251221002555	oxyanion hole [active]
251221002556	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
251221002557	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
251221002558	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
251221002559	hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156
251221002560	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221002561	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
251221002562	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
251221002563	[2Fe-2S] cluster binding site [ion binding]; other site
251221002564	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
251221002565	alpha subunit interface [polypeptide binding]; other site
251221002566	active site
251221002567	substrate binding site [chemical binding]; other site
251221002568	Fe binding site [ion binding]; other site
251221002569	urea carboxylase; Region: urea_carbox; TIGR02712
251221002570	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
251221002571	ATP-grasp domain; Region: ATP-grasp_4; cl17255
251221002572	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
251221002573	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
251221002574	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
251221002575	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
251221002576	carboxyltransferase (CT) interaction site; other site
251221002577	biotinylation site [posttranslational modification]; other site
251221002578	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
251221002579	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
251221002580	allophanate hydrolase; Provisional; Region: PRK08186
251221002581	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
251221002582	AMIN domain; Region: AMIN; pfam11741
251221002583	AMIN domain; Region: AMIN; pfam11741
251221002584	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
251221002585	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
251221002586	active site
251221002587	metal binding site [ion binding]; metal-binding site
251221002588	Lipocalin-like domain; Region: Lipocalin_2; cl19222
251221002589	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
251221002590	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
251221002591	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
251221002592	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
251221002593	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
251221002594	Bacterial Ig-like domain; Region: Big_5; pfam13205
251221002595	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
251221002596	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
251221002597	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
251221002598	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
251221002599	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
251221002600	active site
251221002601	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
251221002602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221002603	ATP binding site [chemical binding]; other site
251221002604	Mg2+ binding site [ion binding]; other site
251221002605	G-X-G motif; other site
251221002606	MAEBL; Provisional; Region: PTZ00121
251221002607	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
251221002608	active site
251221002609	NTP binding site [chemical binding]; other site
251221002610	metal binding triad [ion binding]; metal-binding site
251221002611	HEPN domain; Region: HEPN; pfam05168
251221002612	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
251221002613	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
251221002614	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
251221002615	Ligand binding site; other site
251221002616	DXD motif; other site
251221002617	HEAT repeats; Region: HEAT_2; pfam13646
251221002618	HEAT repeats; Region: HEAT_2; pfam13646
251221002619	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
251221002620	protein binding surface [polypeptide binding]; other site
251221002621	Tubulin like; Region: Tubulin_2; pfam13809
251221002622	Double zinc ribbon; Region: DZR; pfam12773
251221002623	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221002624	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221002625	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221002626	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221002627	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002628	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221002629	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221002630	Transposase; Region: DDE_Tnp_ISL3; pfam01610
251221002631	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
251221002632	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221002633	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
251221002634	30S ribosomal protein S1; Reviewed; Region: PRK07400
251221002635	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
251221002636	RNA binding site [nucleotide binding]; other site
251221002637	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
251221002638	RNA binding site [nucleotide binding]; other site
251221002639	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
251221002640	RNA binding site [nucleotide binding]; other site
251221002641	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
251221002642	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
251221002643	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
251221002644	dimerization interface [polypeptide binding]; other site
251221002645	active site
251221002646	Cyclin-dependent kinase inhibitor 3 (CDKN3); Region: CDKN3; pfam05706
251221002647	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221002648	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
251221002649	catalytic core [active]
251221002650	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
251221002651	active site
251221002652	catalytic residues [active]
251221002653	DNA binding site [nucleotide binding]
251221002654	Int/Topo IB signature motif; other site
251221002655	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002656	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002657	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002658	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002659	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002660	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002661	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002662	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002663	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002664	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002665	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002666	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002667	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002668	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002669	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002670	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002671	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002672	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002673	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002674	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002675	putative phosphoketolase; Provisional; Region: PRK05261
251221002676	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
251221002677	TPP-binding site; other site
251221002678	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
251221002679	XFP C-terminal domain; Region: XFP_C; pfam09363
251221002680	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
251221002681	homodimer interface [polypeptide binding]; other site
251221002682	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
251221002683	active site pocket [active]
251221002684	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
251221002685	catalytic core [active]
251221002686	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
251221002687	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221002688	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
251221002689	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
251221002690	putative dimerization interface [polypeptide binding]; other site
251221002691	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
251221002692	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221002693	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
251221002694	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221002695	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
251221002696	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
251221002697	Fasciclin domain; Region: Fasciclin; pfam02469
251221002698	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221002699	putative active site [active]
251221002700	HemX; Region: HemX; cl19375
251221002701	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221002702	putative active site [active]
251221002703	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221002704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221002705	S-adenosylmethionine binding site [chemical binding]; other site
251221002706	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
251221002707	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
251221002708	Walker A/P-loop; other site
251221002709	ATP binding site [chemical binding]; other site
251221002710	Q-loop/lid; other site
251221002711	ABC transporter signature motif; other site
251221002712	Walker B; other site
251221002713	D-loop; other site
251221002714	H-loop/switch region; other site
251221002715	TOBE domain; Region: TOBE_2; pfam08402
251221002716	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
251221002717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221002718	dimer interface [polypeptide binding]; other site
251221002719	conserved gate region; other site
251221002720	putative PBP binding loops; other site
251221002721	ABC-ATPase subunit interface; other site
251221002722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221002723	dimer interface [polypeptide binding]; other site
251221002724	conserved gate region; other site
251221002725	putative PBP binding loops; other site
251221002726	ABC-ATPase subunit interface; other site
251221002727	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
251221002728	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
251221002729	CHASE3 domain; Region: CHASE3; pfam05227
251221002730	HAMP domain; Region: HAMP; pfam00672
251221002731	GAF domain; Region: GAF_2; pfam13185
251221002732	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
251221002733	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221002734	putative active site [active]
251221002735	heme pocket [chemical binding]; other site
251221002736	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221002737	dimer interface [polypeptide binding]; other site
251221002738	phosphorylation site [posttranslational modification]
251221002739	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221002740	ATP binding site [chemical binding]; other site
251221002741	Mg2+ binding site [ion binding]; other site
251221002742	G-X-G motif; other site
251221002743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221002744	active site
251221002745	phosphorylation site [posttranslational modification]
251221002746	intermolecular recognition site; other site
251221002747	dimerization interface [polypeptide binding]; other site
251221002748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221002749	active site
251221002750	phosphorylation site [posttranslational modification]
251221002751	intermolecular recognition site; other site
251221002752	dimerization interface [polypeptide binding]; other site
251221002753	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
251221002754	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
251221002755	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
251221002756	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
251221002757	dimer interface [polypeptide binding]; other site
251221002758	active site
251221002759	catalytic residue [active]
251221002760	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
251221002761	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
251221002762	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
251221002763	DNA topoisomerase I; Validated; Region: PRK06599
251221002764	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
251221002765	active site
251221002766	interdomain interaction site; other site
251221002767	putative metal-binding site [ion binding]; other site
251221002768	nucleotide binding site [chemical binding]; other site
251221002769	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
251221002770	domain I; other site
251221002771	DNA binding groove [nucleotide binding]
251221002772	phosphate binding site [ion binding]; other site
251221002773	domain II; other site
251221002774	domain III; other site
251221002775	nucleotide binding site [chemical binding]; other site
251221002776	catalytic site [active]
251221002777	domain IV; other site
251221002778	allantoate amidohydrolase; Reviewed; Region: PRK09290
251221002779	Protein of unknown function DUF262; Region: DUF262; pfam03235
251221002780	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
251221002781	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
251221002782	oligomer interface [polypeptide binding]; other site
251221002783	metal binding site [ion binding]; metal-binding site
251221002784	metal binding site [ion binding]; metal-binding site
251221002785	Cl binding site [ion binding]; other site
251221002786	aspartate ring; other site
251221002787	basic sphincter; other site
251221002788	putative hydrophobic gate; other site
251221002789	periplasmic entrance; other site
251221002790	CpeS-like protein; Region: CpeS; pfam09367
251221002791	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
251221002792	putative active site; other site
251221002793	catalytic residue [active]
251221002794	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
251221002795	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
251221002796	ring oligomerisation interface [polypeptide binding]; other site
251221002797	ATP/Mg binding site [chemical binding]; other site
251221002798	stacking interactions; other site
251221002799	hinge regions; other site
251221002800	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
251221002801	oligomerisation interface [polypeptide binding]; other site
251221002802	mobile loop; other site
251221002803	roof hairpin; other site
251221002804	lipoyl synthase; Provisional; Region: PRK05481
251221002805	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221002806	FeS/SAM binding site; other site
251221002807	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221002808	putative active site [active]
251221002809	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
251221002810	MutS domain I; Region: MutS_I; pfam01624
251221002811	MutS domain II; Region: MutS_II; pfam05188
251221002812	MutS domain III; Region: MutS_III; pfam05192
251221002813	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
251221002814	Walker A/P-loop; other site
251221002815	ATP binding site [chemical binding]; other site
251221002816	Q-loop/lid; other site
251221002817	ABC transporter signature motif; other site
251221002818	Walker B; other site
251221002819	D-loop; other site
251221002820	H-loop/switch region; other site
251221002821	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
251221002822	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
251221002823	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
251221002824	hinge; other site
251221002825	active site
251221002826	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
251221002827	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
251221002828	substrate binding site [chemical binding]; other site
251221002829	dimer interface [polypeptide binding]; other site
251221002830	catalytic triad [active]
251221002831	Psb28 protein; Region: Psb28; pfam03912
251221002832	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
251221002833	homopentamer interface [polypeptide binding]; other site
251221002834	active site
251221002835	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
251221002836	deoxyhypusine synthase-like protein; Provisional; Region: PRK00770
251221002837	PIN domain; Region: PIN_2; pfam10130
251221002838	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
251221002839	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
251221002840	FMN binding site [chemical binding]; other site
251221002841	active site
251221002842	catalytic residues [active]
251221002843	substrate binding site [chemical binding]; other site
251221002844	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
251221002845	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
251221002846	argininosuccinate lyase; Provisional; Region: PRK00855
251221002847	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
251221002848	active sites [active]
251221002849	tetramer interface [polypeptide binding]; other site
251221002850	glutamine synthetase, type I; Region: GlnA; TIGR00653
251221002851	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
251221002852	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
251221002853	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
251221002854	nucleoside/Zn binding site; other site
251221002855	dimer interface [polypeptide binding]; other site
251221002856	catalytic motif [active]
251221002857	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
251221002858	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
251221002859	active site
251221002860	catalytic residues [active]
251221002861	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
251221002862	catalytic residues [active]
251221002863	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
251221002864	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
251221002865	DNA binding residues [nucleotide binding]
251221002866	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002867	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002868	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002869	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002870	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002871	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221002872	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221002873	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221002874	binding surface
251221002875	TPR motif; other site
251221002876	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221002877	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221002878	Tetratricopeptide repeat; Region: TPR_10; pfam13374
251221002879	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221002880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221002881	binding surface
251221002882	TPR motif; other site
251221002883	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221002884	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221002885	CHAT domain; Region: CHAT; pfam12770
251221002886	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
251221002887	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
251221002888	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
251221002889	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
251221002890	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
251221002891	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221002892	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
251221002893	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221002894	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221002895	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
251221002896	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
251221002897	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221002898	active site
251221002899	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221002900	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221002901	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221002902	Walker A/P-loop; other site
251221002903	ATP binding site [chemical binding]; other site
251221002904	Q-loop/lid; other site
251221002905	ABC transporter signature motif; other site
251221002906	Walker B; other site
251221002907	D-loop; other site
251221002908	H-loop/switch region; other site
251221002909	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
251221002910	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
251221002911	putative NAD(P) binding site [chemical binding]; other site
251221002912	active site
251221002913	putative substrate binding site [chemical binding]; other site
251221002914	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
251221002915	Protein required for attachment to host cells; Region: Host_attach; pfam10116
251221002916	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
251221002917	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
251221002918	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
251221002919	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
251221002920	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
251221002921	CoA binding domain; Region: CoA_binding_2; pfam13380
251221002922	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
251221002923	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
251221002924	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221002925	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
251221002926	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
251221002927	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
251221002928	Walker A/P-loop; other site
251221002929	ATP binding site [chemical binding]; other site
251221002930	Q-loop/lid; other site
251221002931	ABC transporter signature motif; other site
251221002932	Walker B; other site
251221002933	D-loop; other site
251221002934	H-loop/switch region; other site
251221002935	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
251221002936	Synaphin protein; Region: Synaphin; pfam05835
251221002937	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
251221002938	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
251221002939	active site
251221002940	dimer interface [polypeptide binding]; other site
251221002941	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221002942	active site
251221002943	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
251221002944	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
251221002945	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
251221002946	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
251221002947	PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041
251221002948	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
251221002949	ATP-sulfurylase; Region: ATPS; cd00517
251221002950	active site
251221002951	HXXH motif; other site
251221002952	flexible loop; other site
251221002953	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
251221002954	dimer interface [polypeptide binding]; other site
251221002955	ADP-ribose binding site [chemical binding]; other site
251221002956	active site
251221002957	nudix motif; other site
251221002958	metal binding site [ion binding]; metal-binding site
251221002959	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
251221002960	nudix motif; other site
251221002961	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
251221002962	putative hydrophobic ligand binding site [chemical binding]; other site
251221002963	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
251221002964	active site residue [active]
251221002965	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
251221002966	putative hydrophobic ligand binding site [chemical binding]; other site
251221002967	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
251221002968	active site residue [active]
251221002969	RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6
251221002970	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
251221002971	DNA binding residues [nucleotide binding]
251221002972	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
251221002973	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
251221002974	dimer interface [polypeptide binding]; other site
251221002975	active site
251221002976	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
251221002977	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
251221002978	E3 interaction surface; other site
251221002979	lipoyl attachment site [posttranslational modification]; other site
251221002980	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
251221002981	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221002982	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
251221002983	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
251221002984	tetramer interface [polypeptide binding]; other site
251221002985	TPP-binding site [chemical binding]; other site
251221002986	heterodimer interface [polypeptide binding]; other site
251221002987	phosphorylation loop region [posttranslational modification]
251221002988	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
251221002989	PYR/PP interface [polypeptide binding]; other site
251221002990	dimer interface [polypeptide binding]; other site
251221002991	TPP binding site [chemical binding]; other site
251221002992	Bacterial transcriptional activator domain; Region: BTAD; smart01043
251221002993	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221002994	TPR motif; other site
251221002995	binding surface
251221002996	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221002997	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
251221002998	active site
251221002999	ATP binding site [chemical binding]; other site
251221003000	substrate binding site [chemical binding]; other site
251221003001	activation loop (A-loop); other site
251221003002	Predicted integral membrane protein [Function unknown]; Region: COG5616
251221003003	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
251221003004	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003005	binding surface
251221003006	TPR motif; other site
251221003007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003008	binding surface
251221003009	TPR motif; other site
251221003010	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221003011	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
251221003012	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221003013	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221003014	ligand binding site [chemical binding]; other site
251221003015	flexible hinge region; other site
251221003016	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003017	putative active site [active]
251221003018	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
251221003019	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221003020	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221003021	ligand binding site [chemical binding]; other site
251221003022	flexible hinge region; other site
251221003023	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
251221003024	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
251221003025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221003026	S-adenosylmethionine binding site [chemical binding]; other site
251221003027	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
251221003028	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221003029	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
251221003030	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
251221003031	Cupin-like domain; Region: Cupin_8; pfam13621
251221003032	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
251221003033	Protein of unknown function (DUF497); Region: DUF497; pfam04365
251221003034	Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168
251221003035	glucose-1-dehydrogenase; Provisional; Region: PRK08936
251221003036	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
251221003037	NAD binding site [chemical binding]; other site
251221003038	homodimer interface [polypeptide binding]; other site
251221003039	active site
251221003040	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
251221003041	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003042	putative active site [active]
251221003043	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
251221003044	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
251221003045	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
251221003046	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
251221003047	ThiC family; Region: ThiC; pfam01964
251221003048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221003049	AAA domain; Region: AAA_22; pfam13401
251221003050	Walker A motif; other site
251221003051	ATP binding site [chemical binding]; other site
251221003052	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
251221003053	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003054	TPR motif; other site
251221003055	TPR repeat; Region: TPR_11; pfam13414
251221003056	binding surface
251221003057	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
251221003058	AAA ATPase domain; Region: AAA_16; pfam13191
251221003059	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
251221003060	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
251221003061	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
251221003062	acyl-activating enzyme (AAE) consensus motif; other site
251221003063	active site
251221003064	AMP binding site [chemical binding]; other site
251221003065	CoA binding site [chemical binding]; other site
251221003066	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
251221003067	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
251221003068	PIN domain; Region: PIN_3; pfam13470
251221003069	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
251221003070	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003071	putative active site [active]
251221003072	homoserine kinase; Provisional; Region: PRK01212
251221003073	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
251221003074	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
251221003075	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
251221003076	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221003077	motif II; other site
251221003078	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
251221003079	dimerization interface [polypeptide binding]; other site
251221003080	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
251221003081	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
251221003082	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
251221003083	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
251221003084	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
251221003085	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
251221003086	NAD(P) binding site [chemical binding]; other site
251221003087	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
251221003088	hypothetical protein; Provisional; Region: PRK07208
251221003089	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
251221003090	UDP-galactopyranose mutase; Region: GLF; pfam03275
251221003091	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
251221003092	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
251221003093	putative valine binding site [chemical binding]; other site
251221003094	dimer interface [polypeptide binding]; other site
251221003095	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
251221003096	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
251221003097	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
251221003098	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
251221003099	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
251221003100	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
251221003101	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221003102	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
251221003103	Outer membrane efflux protein; Region: OEP; pfam02321
251221003104	Outer membrane efflux protein; Region: OEP; pfam02321
251221003105	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221003106	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
251221003107	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
251221003108	putative acyl-acceptor binding pocket; other site
251221003109	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
251221003110	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
251221003111	acyl-activating enzyme (AAE) consensus motif; other site
251221003112	AMP binding site [chemical binding]; other site
251221003113	active site
251221003114	CoA binding site [chemical binding]; other site
251221003115	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
251221003116	CHASE2 domain; Region: CHASE2; pfam05226
251221003117	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
251221003118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221003119	Mg2+ binding site [ion binding]; other site
251221003120	Predicted ATPase [General function prediction only]; Region: COG4637
251221003121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221003122	AAA domain; Region: AAA_21; pfam13304
251221003123	Walker A/P-loop; other site
251221003124	ATP binding site [chemical binding]; other site
251221003125	AAA domain; Region: AAA_21; pfam13304
251221003126	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
251221003127	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
251221003128	Moco binding site; other site
251221003129	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
251221003130	metal coordination site [ion binding]; other site
251221003131	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
251221003132	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
251221003133	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221003134	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221003135	ligand binding site [chemical binding]; other site
251221003136	flexible hinge region; other site
251221003137	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
251221003138	DNA binding site [nucleotide binding]
251221003139	sequence specific DNA binding site [nucleotide binding]; other site
251221003140	putative cAMP binding site [chemical binding]; other site
251221003141	RNA polymerase sigma factor; Provisional; Region: PRK12519
251221003142	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221003143	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221003144	DNA binding residues [nucleotide binding]
251221003145	putative anti-sigmaE protein; Provisional; Region: PRK13920
251221003146	Anti-sigma-K factor rskA; Region: RskA; pfam10099
251221003147	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
251221003148	active site
251221003149	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
251221003150	active site
251221003151	metal binding site [ion binding]; metal-binding site
251221003152	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
251221003153	amphipathic channel; other site
251221003154	Asn-Pro-Ala signature motifs; other site
251221003155	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
251221003156	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
251221003157	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221003158	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
251221003159	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
251221003160	active site
251221003161	NTP binding site [chemical binding]; other site
251221003162	metal binding triad [ion binding]; metal-binding site
251221003163	antibiotic binding site [chemical binding]; other site
251221003164	Uncharacterized conserved protein [Function unknown]; Region: COG2361
251221003165	Chlorite dismutase; Region: Chlor_dismutase; cl01280
251221003166	Glucose dehydrogenase; Region: glucose_DH; cd08230
251221003167	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
251221003168	NADP binding site [chemical binding]; other site
251221003169	catalytic Zn binding site [ion binding]; other site
251221003170	structural Zn binding site [ion binding]; other site
251221003171	dimer interface [polypeptide binding]; other site
251221003172	Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168
251221003173	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
251221003174	Glucokinase; Region: Glucokinase; pfam02685
251221003175	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
251221003176	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
251221003177	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
251221003178	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
251221003179	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
251221003180	Electron transfer DM13; Region: DM13; pfam10517
251221003181	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
251221003182	EamA-like transporter family; Region: EamA; pfam00892
251221003183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221003184	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221003185	structural tetrad; other site
251221003186	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221003187	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221003188	structural tetrad; other site
251221003189	WD domain, G-beta repeat; Region: WD40; pfam00400
251221003190	WD40 repeats; Region: WD40; smart00320
251221003191	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221003192	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221003193	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
251221003194	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
251221003195	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
251221003196	NAD binding site [chemical binding]; other site
251221003197	homotetramer interface [polypeptide binding]; other site
251221003198	homodimer interface [polypeptide binding]; other site
251221003199	active site
251221003200	substrate binding site [chemical binding]; other site
251221003201	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221003202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221003203	S-adenosylmethionine binding site [chemical binding]; other site
251221003204	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003205	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
251221003206	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003207	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003208	HEAT repeats; Region: HEAT_2; pfam13646
251221003209	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
251221003210	HEAT-like repeat; Region: HEAT_EZ; pfam13513
251221003211	HEAT repeats; Region: HEAT_2; pfam13646
251221003212	HEAT repeats; Region: HEAT_2; pfam13646
251221003213	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
251221003214	HEAT-like repeat; Region: HEAT_EZ; pfam13513
251221003215	HEAT repeats; Region: HEAT_2; pfam13646
251221003216	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003217	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003218	CpeS-like protein; Region: CpeS; pfam09367
251221003219	CpeS-like protein; Region: CpeS; pfam09367
251221003220	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
251221003221	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
251221003222	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221003223	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
251221003224	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
251221003225	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
251221003226	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
251221003227	PhoD-like phosphatase; Region: PhoD; pfam09423
251221003228	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
251221003229	putative active site [active]
251221003230	putative metal binding site [ion binding]; other site
251221003231	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
251221003232	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
251221003233	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003234	FtsX-like permease family; Region: FtsX; pfam02687
251221003235	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003236	FtsX-like permease family; Region: FtsX; pfam02687
251221003237	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221003238	Transcriptional regulator PadR-like family; Region: PadR; cl17335
251221003239	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
251221003240	Surface antigen; Region: Surface_Ag_2; pfam01617
251221003241	dihydrodipicolinate reductase; Provisional; Region: PRK00048
251221003242	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
251221003243	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
251221003244	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003245	binding surface
251221003246	TPR motif; other site
251221003247	TPR repeat; Region: TPR_11; pfam13414
251221003248	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003249	TPR motif; other site
251221003250	binding surface
251221003251	TPR repeat; Region: TPR_11; pfam13414
251221003252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003253	binding surface
251221003254	TPR repeat; Region: TPR_11; pfam13414
251221003255	TPR motif; other site
251221003256	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
251221003257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003258	binding surface
251221003259	TPR motif; other site
251221003260	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003261	binding surface
251221003262	TPR motif; other site
251221003263	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003264	putative active site [active]
251221003265	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
251221003266	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
251221003267	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
251221003268	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
251221003269	metal binding site [ion binding]; metal-binding site
251221003270	RES domain; Region: RES; cl02411
251221003271	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
251221003272	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003273	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
251221003274	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003275	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003276	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003277	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003278	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003279	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221003280	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003281	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
251221003282	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003283	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003284	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221003285	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003286	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003287	hydrolase, alpha/beta fold family protein; Region: PLN02824
251221003288	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221003289	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
251221003290	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
251221003291	tRNA; other site
251221003292	putative tRNA binding site [nucleotide binding]; other site
251221003293	putative NADP binding site [chemical binding]; other site
251221003294	Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
251221003295	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
251221003296	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
251221003297	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
251221003298	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
251221003299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221003300	ATP binding site [chemical binding]; other site
251221003301	Mg2+ binding site [ion binding]; other site
251221003302	G-X-G motif; other site
251221003303	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
251221003304	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221003305	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
251221003306	homodimer interface [polypeptide binding]; other site
251221003307	substrate-cofactor binding pocket; other site
251221003308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221003309	catalytic residue [active]
251221003310	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816
251221003311	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
251221003312	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221003313	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
251221003314	classical (c) SDRs; Region: SDR_c; cd05233
251221003315	NAD(P) binding site [chemical binding]; other site
251221003316	active site
251221003317	Predicted transcriptional regulators [Transcription]; Region: COG1733
251221003318	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
251221003319	DNA binding residues [nucleotide binding]
251221003320	peptide chain release factor 2; Validated; Region: prfB; PRK00578
251221003321	This domain is found in peptide chain release factors; Region: PCRF; smart00937
251221003322	RF-1 domain; Region: RF-1; pfam00472
251221003323	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
251221003324	active site
251221003325	SAM binding site [chemical binding]; other site
251221003326	homodimer interface [polypeptide binding]; other site
251221003327	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
251221003328	active site
251221003329	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
251221003330	Di-iron ligands [ion binding]; other site
251221003331	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
251221003332	TM-ABC transporter signature motif; other site
251221003333	PAS domain S-box; Region: sensory_box; TIGR00229
251221003334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221003335	putative active site [active]
251221003336	heme pocket [chemical binding]; other site
251221003337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221003338	PAS fold; Region: PAS_3; pfam08447
251221003339	putative active site [active]
251221003340	heme pocket [chemical binding]; other site
251221003341	GAF domain; Region: GAF_2; pfam13185
251221003342	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221003343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221003344	dimer interface [polypeptide binding]; other site
251221003345	phosphorylation site [posttranslational modification]
251221003346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221003347	ATP binding site [chemical binding]; other site
251221003348	Mg2+ binding site [ion binding]; other site
251221003349	G-X-G motif; other site
251221003350	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
251221003351	Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265
251221003352	trimer interface [polypeptide binding]; other site
251221003353	putative active site [active]
251221003354	Zn binding site [ion binding]; other site
251221003355	metal-binding heat shock protein; Provisional; Region: PRK00016
251221003356	phycobillisome linker protein; Region: apcE; CHL00091
251221003357	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003358	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003359	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003360	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003361	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003362	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003363	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003364	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
251221003365	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
251221003366	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
251221003367	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
251221003368	catalytic motif [active]
251221003369	Zn binding site [ion binding]; other site
251221003370	RibD C-terminal domain; Region: RibD_C; cl17279
251221003371	AIR carboxylase; Region: AIRC; pfam00731
251221003372	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
251221003373	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
251221003374	NAD binding site [chemical binding]; other site
251221003375	ATP-grasp domain; Region: ATP-grasp_4; cl17255
251221003376	Phycobilisome protein; Region: Phycobilisome; cl08227
251221003377	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
251221003378	HEAT repeats; Region: HEAT_2; pfam13646
251221003379	protein binding surface [polypeptide binding]; other site
251221003380	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
251221003381	HEAT repeats; Region: HEAT_2; pfam13646
251221003382	protein binding surface [polypeptide binding]; other site
251221003383	HEAT repeats; Region: HEAT_2; pfam13646
251221003384	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221003385	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003386	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003387	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003388	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003389	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221003390	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221003391	CpeS-like protein; Region: CpeS; pfam09367
251221003392	dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247
251221003393	phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13250
251221003394	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003395	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003396	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003397	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003398	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
251221003399	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003400	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
251221003401	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221003402	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
251221003403	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
251221003404	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
251221003405	HEAT repeats; Region: HEAT_2; pfam13646
251221003406	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
251221003407	HEAT repeats; Region: HEAT_2; pfam13646
251221003408	HEAT repeats; Region: HEAT_2; pfam13646
251221003409	HEAT repeats; Region: HEAT_2; pfam13646
251221003410	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
251221003411	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
251221003412	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003413	FtsX-like permease family; Region: FtsX; pfam02687
251221003414	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003415	FtsX-like permease family; Region: FtsX; pfam02687
251221003416	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
251221003417	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221003418	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
251221003419	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
251221003420	Walker A/P-loop; other site
251221003421	ATP binding site [chemical binding]; other site
251221003422	Q-loop/lid; other site
251221003423	ABC transporter signature motif; other site
251221003424	Walker B; other site
251221003425	D-loop; other site
251221003426	H-loop/switch region; other site
251221003427	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
251221003428	active site
251221003429	Zn binding site [ion binding]; other site
251221003430	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221003431	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
251221003432	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
251221003433	putative active site [active]
251221003434	putative catalytic triad [active]
251221003435	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221003436	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221003437	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221003438	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221003439	Y-family of DNA polymerases; Region: PolY; cl12025
251221003440	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
251221003441	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
251221003442	generic binding surface II; other site
251221003443	ssDNA binding site; other site
251221003444	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221003445	ATP binding site [chemical binding]; other site
251221003446	putative Mg++ binding site [ion binding]; other site
251221003447	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221003448	nucleotide binding region [chemical binding]; other site
251221003449	ATP-binding site [chemical binding]; other site
251221003450	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
251221003451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221003452	ATP binding site [chemical binding]; other site
251221003453	Mg2+ binding site [ion binding]; other site
251221003454	G-X-G motif; other site
251221003455	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
251221003456	ATP binding site [chemical binding]; other site
251221003457	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
251221003458	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221003459	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221003460	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
251221003461	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
251221003462	CGNR zinc finger; Region: zf-CGNR; pfam11706
251221003463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
251221003464	MOSC domain; Region: MOSC; pfam03473
251221003465	3-alpha domain; Region: 3-alpha; pfam03475
251221003466	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003467	putative active site [active]
251221003468	elongation factor P; Validated; Region: PRK00529
251221003469	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
251221003470	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
251221003471	RNA binding site [nucleotide binding]; other site
251221003472	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
251221003473	RNA binding site [nucleotide binding]; other site
251221003474	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
251221003475	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
251221003476	carboxyltransferase (CT) interaction site; other site
251221003477	biotinylation site [posttranslational modification]; other site
251221003478	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
251221003479	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
251221003480	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
251221003481	Walker A/P-loop; other site
251221003482	ATP binding site [chemical binding]; other site
251221003483	Q-loop/lid; other site
251221003484	ABC transporter signature motif; other site
251221003485	Walker B; other site
251221003486	D-loop; other site
251221003487	H-loop/switch region; other site
251221003488	TOBE domain; Region: TOBE_2; pfam08402
251221003489	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
251221003490	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221003491	Radical SAM superfamily; Region: Radical_SAM; pfam04055
251221003492	FeS/SAM binding site; other site
251221003493	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003494	putative active site [active]
251221003495	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
251221003496	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
251221003497	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
251221003498	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221003499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221003500	S-adenosylmethionine binding site [chemical binding]; other site
251221003501	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
251221003502	MMPL family; Region: MMPL; cl14618
251221003503	TfuA-like protein; Region: TfuA; pfam07812
251221003504	YcaO-like family; Region: YcaO; pfam02624
251221003505	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221003506	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221003507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221003508	Walker A/P-loop; other site
251221003509	ATP binding site [chemical binding]; other site
251221003510	Q-loop/lid; other site
251221003511	ABC transporter signature motif; other site
251221003512	Walker B; other site
251221003513	D-loop; other site
251221003514	H-loop/switch region; other site
251221003515	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221003516	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221003517	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221003518	Walker A/P-loop; other site
251221003519	ATP binding site [chemical binding]; other site
251221003520	Q-loop/lid; other site
251221003521	ABC transporter signature motif; other site
251221003522	Walker B; other site
251221003523	D-loop; other site
251221003524	H-loop/switch region; other site
251221003525	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
251221003526	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
251221003527	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
251221003528	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
251221003529	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
251221003530	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
251221003531	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221003532	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221003533	N-terminal plug; other site
251221003534	ligand-binding site [chemical binding]; other site
251221003535	glycogen branching enzyme; Provisional; Region: PRK05402
251221003536	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
251221003537	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
251221003538	active site
251221003539	catalytic site [active]
251221003540	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
251221003541	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
251221003542	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
251221003543	active site
251221003544	putative substrate binding pocket [chemical binding]; other site
251221003545	Tricorn protease C1 domain; Region: Tricorn_C1; pfam14684
251221003546	C-terminal peptidase (prc); Region: prc; TIGR00225
251221003547	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
251221003548	protein binding site [polypeptide binding]; other site
251221003549	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
251221003550	Catalytic dyad [active]
251221003551	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
251221003552	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221003553	active site
251221003554	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
251221003555	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
251221003556	tellurium resistance terB-like protein; Region: terB_like; cd07177
251221003557	metal binding site [ion binding]; metal-binding site
251221003558	PhoD-like phosphatase; Region: PhoD; pfam09423
251221003559	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
251221003560	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
251221003561	putative active site [active]
251221003562	putative metal binding site [ion binding]; other site
251221003563	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
251221003564	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
251221003565	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
251221003566	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
251221003567	active site
251221003568	dimerization interface [polypeptide binding]; other site
251221003569	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
251221003570	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
251221003571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221003572	homodimer interface [polypeptide binding]; other site
251221003573	catalytic residue [active]
251221003574	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
251221003575	histidinol dehydrogenase; Region: hisD; TIGR00069
251221003576	NAD binding site [chemical binding]; other site
251221003577	dimerization interface [polypeptide binding]; other site
251221003578	product binding site; other site
251221003579	substrate binding site [chemical binding]; other site
251221003580	zinc binding site [ion binding]; other site
251221003581	catalytic residues [active]
251221003582	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
251221003583	putative active site [active]
251221003584	catalytic triad [active]
251221003585	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
251221003586	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
251221003587	putative active site [active]
251221003588	catalytic site [active]
251221003589	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
251221003590	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003591	putative active site [active]
251221003592	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
251221003593	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
251221003594	cobalamin binding residues [chemical binding]; other site
251221003595	putative BtuC binding residues; other site
251221003596	dimer interface [polypeptide binding]; other site
251221003597	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
251221003598	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
251221003599	RES domain; Region: RES; pfam08808
251221003600	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
251221003601	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
251221003602	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221003603	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
251221003604	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221003605	DNA binding residues [nucleotide binding]
251221003606	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
251221003607	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
251221003608	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
251221003609	protein binding site [polypeptide binding]; other site
251221003610	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
251221003611	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
251221003612	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
251221003613	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
251221003614	Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cl02573
251221003615	Peptidase family M48; Region: Peptidase_M48; pfam01435
251221003616	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
251221003617	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221003618	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
251221003619	putative dimerization interface [polypeptide binding]; other site
251221003620	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
251221003621	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
251221003622	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
251221003623	TrkA-N domain; Region: TrkA_N; pfam02254
251221003624	Hermansky-Pudlak syndrome 3, middle region; Region: HPS3_Mid; pfam14762
251221003625	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221003626	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221003627	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221003628	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221003629	active site
251221003630	ATP binding site [chemical binding]; other site
251221003631	substrate binding site [chemical binding]; other site
251221003632	activation loop (A-loop); other site
251221003633	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221003634	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221003635	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
251221003636	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221003637	dimerization interface [polypeptide binding]; other site
251221003638	Double zinc ribbon; Region: DZR; pfam12773
251221003639	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
251221003640	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
251221003641	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
251221003642	phosphopeptide binding site; other site
251221003643	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221003644	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
251221003645	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221003646	motif II; other site
251221003647	UGMP family protein; Validated; Region: PRK09604
251221003648	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
251221003649	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
251221003650	Protein of unknown function (DUF422); Region: DUF422; cl00991
251221003651	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
251221003652	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
251221003653	active site
251221003654	Putative restriction endonuclease; Region: Uma2; pfam05685
251221003655	putative active site [active]
251221003656	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
251221003657	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
251221003658	tellurium resistance terB-like protein; Region: terB_like; cd07177
251221003659	metal binding site [ion binding]; metal-binding site
251221003660	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
251221003661	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
251221003662	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
251221003663	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
251221003664	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
251221003665	active site
251221003666	metal binding site [ion binding]; metal-binding site
251221003667	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
251221003668	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221003669	ATP binding site [chemical binding]; other site
251221003670	putative Mg++ binding site [ion binding]; other site
251221003671	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221003672	nucleotide binding region [chemical binding]; other site
251221003673	ATP-binding site [chemical binding]; other site
251221003674	Protein of unknown function (DUF790); Region: DUF790; cl19837
251221003675	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003676	putative active site [active]
251221003677	PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121
251221003678	apical/protease domain interface [polypeptide binding]; other site
251221003679	substrate binding [chemical binding]; other site
251221003680	dimer interface [polypeptide binding]; other site
251221003681	M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022
251221003682	dimer interface [polypeptide binding]; other site
251221003683	active site
251221003684	metal binding site [ion binding]; metal-binding site
251221003685	Transferrin receptor-like dimerization domain; Region: TFR_dimer; pfam04253
251221003686	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221003687	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221003688	Transcriptional regulator; Region: Rrf2; cl17282
251221003689	Rrf2 family protein; Region: rrf2_super; TIGR00738
251221003690	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
251221003691	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
251221003692	FeS assembly ATPase SufC; Region: sufC; TIGR01978
251221003693	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
251221003694	Walker A/P-loop; other site
251221003695	ATP binding site [chemical binding]; other site
251221003696	Q-loop/lid; other site
251221003697	ABC transporter signature motif; other site
251221003698	Walker B; other site
251221003699	D-loop; other site
251221003700	H-loop/switch region; other site
251221003701	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
251221003702	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
251221003703	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
251221003704	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221003705	catalytic residue [active]
251221003706	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
251221003707	trimerization site [polypeptide binding]; other site
251221003708	active site
251221003709	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
251221003710	Bacterial transcriptional activator domain; Region: BTAD; smart01043
251221003711	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221003712	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003713	binding surface
251221003714	TPR motif; other site
251221003715	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221003716	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
251221003717	active site
251221003718	SAM binding site [chemical binding]; other site
251221003719	homodimer interface [polypeptide binding]; other site
251221003720	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003721	putative active site [active]
251221003722	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
251221003723	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
251221003724	active site
251221003725	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
251221003726	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
251221003727	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003728	putative active site [active]
251221003729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003730	TPR repeat; Region: TPR_11; pfam13414
251221003731	binding surface
251221003732	TPR motif; other site
251221003733	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003734	binding surface
251221003735	TPR motif; other site
251221003736	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
251221003737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003738	binding surface
251221003739	TPR motif; other site
251221003740	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221003741	binding surface
251221003742	TPR motif; other site
251221003743	Sulfotransferase domain; Region: Sulfotransfer_1; cl19239
251221003744	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221003745	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221003746	N-terminal plug; other site
251221003747	ligand-binding site [chemical binding]; other site
251221003748	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221003749	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
251221003750	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
251221003751	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
251221003752	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
251221003753	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
251221003754	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
251221003755	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
251221003756	P loop; other site
251221003757	Nucleotide binding site [chemical binding]; other site
251221003758	DTAP/Switch II; other site
251221003759	Switch I; other site
251221003760	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
251221003761	adenylate kinase; Reviewed; Region: adk; PRK00279
251221003762	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
251221003763	AMP-binding site [chemical binding]; other site
251221003764	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
251221003765	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
251221003766	SecY translocase; Region: SecY; pfam00344
251221003767	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
251221003768	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
251221003769	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221003770	FeS/SAM binding site; other site
251221003771	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
251221003772	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
251221003773	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
251221003774	putative active site pocket [active]
251221003775	dimerization interface [polypeptide binding]; other site
251221003776	putative catalytic residue [active]
251221003777	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
251221003778	Thf1-like protein; Reviewed; Region: PRK13266
251221003779	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
251221003780	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
251221003781	active site
251221003782	cosubstrate binding site; other site
251221003783	substrate binding site [chemical binding]; other site
251221003784	catalytic site [active]
251221003785	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
251221003786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221003787	dimer interface [polypeptide binding]; other site
251221003788	conserved gate region; other site
251221003789	putative PBP binding loops; other site
251221003790	ABC-ATPase subunit interface; other site
251221003791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221003792	dimer interface [polypeptide binding]; other site
251221003793	conserved gate region; other site
251221003794	putative PBP binding loops; other site
251221003795	ABC-ATPase subunit interface; other site
251221003796	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
251221003797	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221003798	Walker A/P-loop; other site
251221003799	ATP binding site [chemical binding]; other site
251221003800	Q-loop/lid; other site
251221003801	ABC transporter signature motif; other site
251221003802	Walker B; other site
251221003803	D-loop; other site
251221003804	H-loop/switch region; other site
251221003805	TOBE domain; Region: TOBE_2; pfam08402
251221003806	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
251221003807	active site
251221003808	Double zinc ribbon; Region: DZR; pfam12773
251221003809	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
251221003810	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
251221003811	phosphopeptide binding site; other site
251221003812	CARDB; Region: CARDB; pfam07705
251221003813	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221003814	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221003815	structural tetrad; other site
251221003816	Merozoite surface antigen 2c; Region: MSA-2c; pfam12238
251221003817	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
251221003818	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
251221003819	phage tail protein domain; Region: tail_TIGR02242
251221003820	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
251221003821	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
251221003822	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221003823	putative active site [active]
251221003824	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
251221003825	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
251221003826	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221003827	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221003828	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
251221003829	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003830	FtsX-like permease family; Region: FtsX; pfam02687
251221003831	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003832	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221003833	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221003834	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
251221003835	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221003836	NAD(P) binding site [chemical binding]; other site
251221003837	active site
251221003838	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221003839	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221003840	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221003841	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
251221003842	NAD(P) binding site [chemical binding]; other site
251221003843	active site
251221003844	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
251221003845	active site
251221003846	NTP binding site [chemical binding]; other site
251221003847	metal binding triad [ion binding]; metal-binding site
251221003848	HEPN domain; Region: HEPN; cl00824
251221003849	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
251221003850	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
251221003851	Walker A/P-loop; other site
251221003852	ATP binding site [chemical binding]; other site
251221003853	Q-loop/lid; other site
251221003854	ABC transporter signature motif; other site
251221003855	Walker B; other site
251221003856	D-loop; other site
251221003857	H-loop/switch region; other site
251221003858	DevC protein; Region: devC; TIGR01185
251221003859	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003860	FtsX-like permease family; Region: FtsX; pfam02687
251221003861	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221003862	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
251221003863	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221003864	Predicted transcriptional regulators [Transcription]; Region: COG1695
251221003865	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
251221003866	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
251221003867	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221003868	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
251221003869	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
251221003870	glycogen binding site [chemical binding]; other site
251221003871	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
251221003872	active site
251221003873	catalytic site [active]
251221003874	DNA polymerase III subunit delta'; Validated; Region: PRK07399
251221003875	AAA ATPase domain; Region: AAA_16; pfam13191
251221003876	DNA polymerase III subunit delta'; Validated; Region: PRK08485
251221003877	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221003878	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
251221003879	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
251221003880	putative hydrophobic ligand binding site [chemical binding]; other site
251221003881	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
251221003882	dimerization interface [polypeptide binding]; other site
251221003883	putative DNA binding site [nucleotide binding]; other site
251221003884	putative Zn2+ binding site [ion binding]; other site
251221003885	Predicted transcriptional regulators [Transcription]; Region: COG1695
251221003886	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
251221003887	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
251221003888	putative NAD(P) binding site [chemical binding]; other site
251221003889	PsbP; Region: PsbP; cl03356
251221003890	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
251221003891	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
251221003892	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
251221003893	GIY-YIG motif/motif A; other site
251221003894	active site
251221003895	catalytic site [active]
251221003896	putative DNA binding site [nucleotide binding]; other site
251221003897	metal binding site [ion binding]; metal-binding site
251221003898	UvrB/uvrC motif; Region: UVR; pfam02151
251221003899	light-harvesting-like protein 3; Provisional; Region: PLN00014
251221003900	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
251221003901	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
251221003902	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
251221003903	dimer interface [polypeptide binding]; other site
251221003904	motif 1; other site
251221003905	active site
251221003906	motif 2; other site
251221003907	motif 3; other site
251221003908	Uncharacterized conserved protein [Function unknown]; Region: COG1432
251221003909	LabA_like proteins; Region: LabA; cd10911
251221003910	putative metal binding site [ion binding]; other site
251221003911	Exoribonuclease R [Transcription]; Region: VacB; COG0557
251221003912	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
251221003913	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
251221003914	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
251221003915	RNA binding site [nucleotide binding]; other site
251221003916	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
251221003917	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
251221003918	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
251221003919	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221003920	N-terminal plug; other site
251221003921	ligand-binding site [chemical binding]; other site
251221003922	FOG: CBS domain [General function prediction only]; Region: COG0517
251221003923	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
251221003924	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
251221003925	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
251221003926	active site
251221003927	NTP binding site [chemical binding]; other site
251221003928	metal binding triad [ion binding]; metal-binding site
251221003929	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
251221003930	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
251221003931	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
251221003932	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221003933	Ligand Binding Site [chemical binding]; other site
251221003934	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
251221003935	putative active site [active]
251221003936	metal binding site [ion binding]; metal-binding site
251221003937	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
251221003938	Aspartase; Region: Aspartase; cd01357
251221003939	active sites [active]
251221003940	tetramer interface [polypeptide binding]; other site
251221003941	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
251221003942	active site
251221003943	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
251221003944	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
251221003945	Ycf39; Provisional; Region: ycf39; CHL00194
251221003946	NAD(P) binding site [chemical binding]; other site
251221003947	putative active site [active]
251221003948	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
251221003949	DNA binding site [nucleotide binding]
251221003950	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
251221003951	active site
251221003952	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
251221003953	AIR carboxylase; Region: AIRC; smart01001
251221003954	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
251221003955	homodimer interface [polypeptide binding]; other site
251221003956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221003957	catalytic residue [active]
251221003958	epoxyqueuosine reductase; Region: TIGR00276
251221003959	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
251221003960	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
251221003961	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
251221003962	trimer interface [polypeptide binding]; other site
251221003963	active site
251221003964	rod shape-determining protein MreB; Provisional; Region: PRK13927
251221003965	MreB and similar proteins; Region: MreB_like; cd10225
251221003966	nucleotide binding site [chemical binding]; other site
251221003967	Mg binding site [ion binding]; other site
251221003968	putative protofilament interaction site [polypeptide binding]; other site
251221003969	RodZ interaction site [polypeptide binding]; other site
251221003970	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
251221003971	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
251221003972	active site
251221003973	ATP binding site [chemical binding]; other site
251221003974	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
251221003975	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221003976	integral membrane protein MviN; Region: mviN; TIGR01695
251221003977	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
251221003978	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
251221003979	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
251221003980	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
251221003981	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
251221003982	DnaA N-terminal domain; Region: DnaA_N; pfam11638
251221003983	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221003984	Walker A motif; other site
251221003985	ATP binding site [chemical binding]; other site
251221003986	Walker B motif; other site
251221003987	arginine finger; other site
251221003988	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
251221003989	DnaA box-binding interface [nucleotide binding]; other site
251221003990	Ribosomal protein L34; Region: Ribosomal_L34; pfam00468
251221003991	Ribonuclease P; Region: Ribonuclease_P; cl00457
251221003992	Bacterial PH domain; Region: bPH_2; pfam03703
251221003993	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
251221003994	Transcriptional regulator PadR-like family; Region: PadR; cl17335
251221003995	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
251221003996	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003997	FtsX-like permease family; Region: FtsX; pfam02687
251221003998	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221003999	FtsX-like permease family; Region: FtsX; pfam02687
251221004000	antiporter inner membrane protein; Provisional; Region: PRK11670
251221004001	Domain of unknown function DUF59; Region: DUF59; pfam01883
251221004002	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
251221004003	Walker A motif; other site
251221004004	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221004005	PUCC protein; Region: PUCC; pfam03209
251221004006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221004007	putative substrate translocation pore; other site
251221004008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004009	S-adenosylmethionine binding site [chemical binding]; other site
251221004010	YlqD protein; Region: YlqD; pfam11068
251221004011	Ferredoxin [Energy production and conversion]; Region: COG1146
251221004012	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
251221004013	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
251221004014	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
251221004015	homooctamer interface [polypeptide binding]; other site
251221004016	active site
251221004017	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221004018	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221004019	N-terminal plug; other site
251221004020	ligand-binding site [chemical binding]; other site
251221004021	Predicted ATPase [General function prediction only]; Region: COG4637
251221004022	AAA domain; Region: AAA_23; pfam13476
251221004023	Walker A/P-loop; other site
251221004024	ATP binding site [chemical binding]; other site
251221004025	Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability; Region: TRFH; cl02779
251221004026	dimer interface [polypeptide binding]; other site
251221004027	AAA domain; Region: AAA_21; pfam13304
251221004028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221004029	Major Facilitator Superfamily; Region: MFS_1; pfam07690
251221004030	putative substrate translocation pore; other site
251221004031	Transglycosylase; Region: Transgly; pfam00912
251221004032	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
251221004033	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
251221004034	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
251221004035	Thioredoxin; Region: Thioredoxin_4; pfam13462
251221004036	PAS domain S-box; Region: sensory_box; TIGR00229
251221004037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221004038	putative active site [active]
251221004039	heme pocket [chemical binding]; other site
251221004040	GAF domain; Region: GAF_2; pfam13185
251221004041	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221004042	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221004043	dimer interface [polypeptide binding]; other site
251221004044	phosphorylation site [posttranslational modification]
251221004045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004046	ATP binding site [chemical binding]; other site
251221004047	Mg2+ binding site [ion binding]; other site
251221004048	G-X-G motif; other site
251221004049	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
251221004050	SmpB-tmRNA interface; other site
251221004051	glutamate racemase; Provisional; Region: PRK00865
251221004052	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
251221004053	Bacterial Ig-like domain; Region: Big_5; pfam13205
251221004054	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
251221004055	active site
251221004056	polyphosphate kinase; Provisional; Region: PRK05443
251221004057	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
251221004058	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
251221004059	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
251221004060	putative domain interface [polypeptide binding]; other site
251221004061	putative active site [active]
251221004062	catalytic site [active]
251221004063	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
251221004064	putative domain interface [polypeptide binding]; other site
251221004065	putative active site [active]
251221004066	catalytic site [active]
251221004067	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
251221004068	Peptidase family M50; Region: Peptidase_M50; pfam02163
251221004069	active site
251221004070	putative substrate binding region [chemical binding]; other site
251221004071	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
251221004072	TIGR03032 family protein; Region: TIGR03032
251221004073	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
251221004074	NAD(P) binding site [chemical binding]; other site
251221004075	catalytic residues [active]
251221004076	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
251221004077	RimM N-terminal domain; Region: RimM; pfam01782
251221004078	PRC-barrel domain; Region: PRC; pfam05239
251221004079	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
251221004080	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
251221004081	homodimer interface [polypeptide binding]; other site
251221004082	oligonucleotide binding site [chemical binding]; other site
251221004083	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
251221004084	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
251221004085	RNA/DNA hybrid binding site [nucleotide binding]; other site
251221004086	active site
251221004087	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
251221004088	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
251221004089	active site
251221004090	dimer interface [polypeptide binding]; other site
251221004091	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
251221004092	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
251221004093	active site
251221004094	FMN binding site [chemical binding]; other site
251221004095	substrate binding site [chemical binding]; other site
251221004096	3Fe-4S cluster binding site [ion binding]; other site
251221004097	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
251221004098	domain interface; other site
251221004099	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
251221004100	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779
251221004101	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
251221004102	DNA binding residues [nucleotide binding]
251221004103	putative dimer interface [polypeptide binding]; other site
251221004104	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
251221004105	dimer interface [polypeptide binding]; other site
251221004106	substrate binding site [chemical binding]; other site
251221004107	ATP binding site [chemical binding]; other site
251221004108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004109	S-adenosylmethionine binding site [chemical binding]; other site
251221004110	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221004111	putative active site [active]
251221004112	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
251221004113	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221004114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004115	S-adenosylmethionine binding site [chemical binding]; other site
251221004116	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221004117	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004118	S-adenosylmethionine binding site [chemical binding]; other site
251221004119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
251221004120	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221004121	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004122	S-adenosylmethionine binding site [chemical binding]; other site
251221004123	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
251221004124	putative hexamer interface [polypeptide binding]; other site
251221004125	putative hexagonal pore; other site
251221004126	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
251221004127	putative hexamer interface [polypeptide binding]; other site
251221004128	putative hexagonal pore; other site
251221004129	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
251221004130	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
251221004131	G1 box; other site
251221004132	putative GEF interaction site [polypeptide binding]; other site
251221004133	GTP/Mg2+ binding site [chemical binding]; other site
251221004134	Switch I region; other site
251221004135	G2 box; other site
251221004136	G3 box; other site
251221004137	Switch II region; other site
251221004138	G4 box; other site
251221004139	G5 box; other site
251221004140	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
251221004141	Elongation Factor G, domain II; Region: EFG_II; pfam14492
251221004142	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
251221004143	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
251221004144	catalytic loop [active]
251221004145	iron binding site [ion binding]; other site
251221004146	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
251221004147	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221004148	putative active site [active]
251221004149	CTP synthetase; Validated; Region: pyrG; PRK05380
251221004150	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
251221004151	Catalytic site [active]
251221004152	active site
251221004153	UTP binding site [chemical binding]; other site
251221004154	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
251221004155	active site
251221004156	putative oxyanion hole; other site
251221004157	catalytic triad [active]
251221004158	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
251221004159	Active site serine [active]
251221004160	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221004161	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
251221004162	putative ADP-binding pocket [chemical binding]; other site
251221004163	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
251221004164	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
251221004165	tetramer interface [polypeptide binding]; other site
251221004166	TPP-binding site [chemical binding]; other site
251221004167	heterodimer interface [polypeptide binding]; other site
251221004168	phosphorylation loop region [posttranslational modification]
251221004169	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
251221004170	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
251221004171	alpha subunit interface [polypeptide binding]; other site
251221004172	TPP binding site [chemical binding]; other site
251221004173	heterodimer interface [polypeptide binding]; other site
251221004174	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
251221004175	CpeS-like protein; Region: CpeS; pfam09367
251221004176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221004177	active site
251221004178	phosphorylation site [posttranslational modification]
251221004179	intermolecular recognition site; other site
251221004180	dimerization interface [polypeptide binding]; other site
251221004181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221004182	active site
251221004183	phosphorylation site [posttranslational modification]
251221004184	intermolecular recognition site; other site
251221004185	dimerization interface [polypeptide binding]; other site
251221004186	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
251221004187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221004188	putative active site [active]
251221004189	heme pocket [chemical binding]; other site
251221004190	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221004191	dimer interface [polypeptide binding]; other site
251221004192	phosphorylation site [posttranslational modification]
251221004193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004194	ATP binding site [chemical binding]; other site
251221004195	Mg2+ binding site [ion binding]; other site
251221004196	G-X-G motif; other site
251221004197	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221004198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221004199	active site
251221004200	phosphorylation site [posttranslational modification]
251221004201	intermolecular recognition site; other site
251221004202	dimerization interface [polypeptide binding]; other site
251221004203	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
251221004204	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
251221004205	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
251221004206	trimer interface [polypeptide binding]; other site
251221004207	active site
251221004208	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
251221004209	catalytic site [active]
251221004210	Mechanosensitive ion channel; Region: MS_channel; pfam00924
251221004211	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
251221004212	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
251221004213	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cd04371
251221004214	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
251221004215	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221004216	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221004217	Clp protease ATP binding subunit; Region: clpC; CHL00095
251221004218	Clp amino terminal domain; Region: Clp_N; pfam02861
251221004219	Clp amino terminal domain; Region: Clp_N; pfam02861
251221004220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221004221	Walker A motif; other site
251221004222	ATP binding site [chemical binding]; other site
251221004223	Walker B motif; other site
251221004224	arginine finger; other site
251221004225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221004226	Walker A motif; other site
251221004227	ATP binding site [chemical binding]; other site
251221004228	Walker B motif; other site
251221004229	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
251221004230	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
251221004231	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
251221004232	Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219
251221004233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221004234	Major Facilitator Superfamily; Region: MFS_1; pfam07690
251221004235	putative substrate translocation pore; other site
251221004236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004237	TPR motif; other site
251221004238	TPR repeat; Region: TPR_11; pfam13414
251221004239	binding surface
251221004240	TPR repeat; Region: TPR_11; pfam13414
251221004241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004242	binding surface
251221004243	TPR motif; other site
251221004244	TPR repeat; Region: TPR_11; pfam13414
251221004245	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004246	binding surface
251221004247	TPR motif; other site
251221004248	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
251221004249	Flavoprotein; Region: Flavoprotein; cl19190
251221004250	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
251221004251	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
251221004252	Neogenin C-terminus; Region: Neogenin_C; pfam06583
251221004253	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
251221004254	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221004255	active site
251221004256	ATP binding site [chemical binding]; other site
251221004257	substrate binding site [chemical binding]; other site
251221004258	activation loop (A-loop); other site
251221004259	TPR repeat; Region: TPR_11; pfam13414
251221004260	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004261	binding surface
251221004262	TPR motif; other site
251221004263	TPR repeat; Region: TPR_11; pfam13414
251221004264	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
251221004265	Subtilase family; Region: Peptidase_S8; pfam00082
251221004266	active site
251221004267	catalytic triad [active]
251221004268	Membrane protein of unknown function; Region: DUF360; pfam04020
251221004269	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
251221004270	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
251221004271	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
251221004272	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
251221004273	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
251221004274	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
251221004275	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221004276	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
251221004277	dimerization interface [polypeptide binding]; other site
251221004278	hypothetical protein; Provisional; Region: PRK07394
251221004279	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
251221004280	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
251221004281	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221004282	putative active site [active]
251221004283	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221004284	putative active site [active]
251221004285	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
251221004286	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
251221004287	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
251221004288	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
251221004289	NMT1-like family; Region: NMT1_2; pfam13379
251221004290	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
251221004291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221004292	dimer interface [polypeptide binding]; other site
251221004293	conserved gate region; other site
251221004294	putative PBP binding loops; other site
251221004295	ABC-ATPase subunit interface; other site
251221004296	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
251221004297	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
251221004298	Walker A/P-loop; other site
251221004299	ATP binding site [chemical binding]; other site
251221004300	Q-loop/lid; other site
251221004301	ABC transporter signature motif; other site
251221004302	Walker B; other site
251221004303	D-loop; other site
251221004304	H-loop/switch region; other site
251221004305	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
251221004306	NMT1-like family; Region: NMT1_2; pfam13379
251221004307	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
251221004308	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
251221004309	Walker A/P-loop; other site
251221004310	ATP binding site [chemical binding]; other site
251221004311	Q-loop/lid; other site
251221004312	ABC transporter signature motif; other site
251221004313	Walker B; other site
251221004314	D-loop; other site
251221004315	H-loop/switch region; other site
251221004316	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
251221004317	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
251221004318	[4Fe-4S] binding site [ion binding]; other site
251221004319	molybdopterin cofactor binding site; other site
251221004320	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
251221004321	molybdopterin cofactor binding site; other site
251221004322	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
251221004323	heme-binding site [chemical binding]; other site
251221004324	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
251221004325	putative active site [active]
251221004326	HEAT repeats; Region: HEAT_2; pfam13646
251221004327	HEAT repeats; Region: HEAT_2; pfam13646
251221004328	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
251221004329	HEAT repeats; Region: HEAT_2; pfam13646
251221004330	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
251221004331	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
251221004332	putative active site [active]
251221004333	Protein of unknown function (DUF721); Region: DUF721; pfam05258
251221004334	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
251221004335	homodecamer interface [polypeptide binding]; other site
251221004336	active site
251221004337	putative catalytic site residues [active]
251221004338	zinc binding site [ion binding]; other site
251221004339	GTP-CH-I/GFRP interaction surface; other site
251221004340	short chain dehydrogenase; Provisional; Region: PRK07454
251221004341	classical (c) SDRs; Region: SDR_c; cd05233
251221004342	NAD(P) binding site [chemical binding]; other site
251221004343	active site
251221004344	Uncharacterized conserved protein [Function unknown]; Region: COG5613; cl19899
251221004345	NADH dehydrogenase; Region: NADHdh; cl00469
251221004346	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221004347	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221004348	dimer interface [polypeptide binding]; other site
251221004349	phosphorylation site [posttranslational modification]
251221004350	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
251221004351	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221004352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221004353	dimer interface [polypeptide binding]; other site
251221004354	phosphorylation site [posttranslational modification]
251221004355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004356	ATP binding site [chemical binding]; other site
251221004357	Mg2+ binding site [ion binding]; other site
251221004358	G-X-G motif; other site
251221004359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221004360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221004361	active site
251221004362	phosphorylation site [posttranslational modification]
251221004363	intermolecular recognition site; other site
251221004364	dimerization interface [polypeptide binding]; other site
251221004365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221004366	DNA binding residues [nucleotide binding]
251221004367	dimerization interface [polypeptide binding]; other site
251221004368	Sulfatase; Region: Sulfatase; cl19157
251221004369	Sulfatase; Region: Sulfatase; cl19157
251221004370	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221004371	putative active site [active]
251221004372	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
251221004373	Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
251221004374	active site
251221004375	catalytic site [active]
251221004376	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
251221004377	catalytic core [active]
251221004378	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
251221004379	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
251221004380	active site
251221004381	dimer interface [polypeptide binding]; other site
251221004382	catalytic residue [active]
251221004383	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
251221004384	Ca2+ binding site [ion binding]; other site
251221004385	Predicted membrane protein [Function unknown]; Region: COG4803
251221004386	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
251221004387	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
251221004388	23S rRNA interface [nucleotide binding]; other site
251221004389	L7/L12 interface [polypeptide binding]; other site
251221004390	putative thiostrepton binding site; other site
251221004391	L25 interface [polypeptide binding]; other site
251221004392	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
251221004393	mRNA/rRNA interface [nucleotide binding]; other site
251221004394	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
251221004395	23S rRNA interface [nucleotide binding]; other site
251221004396	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
251221004397	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
251221004398	core dimer interface [polypeptide binding]; other site
251221004399	peripheral dimer interface [polypeptide binding]; other site
251221004400	L10 interface [polypeptide binding]; other site
251221004401	L11 interface [polypeptide binding]; other site
251221004402	putative EF-Tu interaction site [polypeptide binding]; other site
251221004403	putative EF-G interaction site [polypeptide binding]; other site
251221004404	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
251221004405	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
251221004406	active site
251221004407	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
251221004408	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
251221004409	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
251221004410	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221004411	putative active site [active]
251221004412	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
251221004413	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
251221004414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221004415	Walker A motif; other site
251221004416	ATP binding site [chemical binding]; other site
251221004417	Walker B motif; other site
251221004418	arginine finger; other site
251221004419	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
251221004420	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
251221004421	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
251221004422	DDE superfamily endonuclease; Region: DDE_3; pfam13358
251221004423	Homeodomain-like domain; Region: HTH_23; cl17451
251221004424	Winged helix-turn helix; Region: HTH_29; pfam13551
251221004425	CpeS-like protein; Region: CpeS; pfam09367
251221004426	Mechanosensitive ion channel; Region: MS_channel; pfam00924
251221004427	Exoribonuclease R [Transcription]; Region: VacB; COG0557
251221004428	RNB domain; Region: RNB; pfam00773
251221004429	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221004430	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
251221004431	active site
251221004432	catalytic tetrad [active]
251221004433	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
251221004434	putative active site [active]
251221004435	Zn binding site [ion binding]; other site
251221004436	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
251221004437	Guanylate kinase; Region: Guanylate_kin; pfam00625
251221004438	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
251221004439	catalytic site [active]
251221004440	G-X2-G-X-G-K; other site
251221004441	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
251221004442	Domain of unknown function (DUF814); Region: DUF814; pfam05670
251221004443	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
251221004444	Peptidase family M48; Region: Peptidase_M48; pfam01435
251221004445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004446	S-adenosylmethionine binding site [chemical binding]; other site
251221004447	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
251221004448	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
251221004449	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
251221004450	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
251221004451	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
251221004452	Caspase domain; Region: Peptidase_C14; pfam00656
251221004453	AAA ATPase domain; Region: AAA_16; pfam13191
251221004454	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221004455	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221004456	structural tetrad; other site
251221004457	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221004458	structural tetrad; other site
251221004459	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221004460	WD40 repeats; Region: WD40; smart00320
251221004461	WD domain, G-beta repeat; Region: WD40; pfam00400
251221004462	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
251221004463	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
251221004464	DinB superfamily; Region: DinB_2; pfam12867
251221004465	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781
251221004466	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
251221004467	Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017
251221004468	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
251221004469	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
251221004470	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221004471	Coenzyme A binding pocket [chemical binding]; other site
251221004472	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
251221004473	homotrimer interaction site [polypeptide binding]; other site
251221004474	putative active site [active]
251221004475	Predicted transcriptional regulator [Transcription]; Region: COG2944
251221004476	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221004477	non-specific DNA binding site [nucleotide binding]; other site
251221004478	salt bridge; other site
251221004479	sequence-specific DNA binding site [nucleotide binding]; other site
251221004480	RIP metalloprotease RseP; Region: TIGR00054
251221004481	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
251221004482	active site
251221004483	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
251221004484	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
251221004485	putative substrate binding region [chemical binding]; other site
251221004486	putative substrate binding region [chemical binding]; other site
251221004487	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
251221004488	aromatic arch; other site
251221004489	DCoH dimer interaction site [polypeptide binding]; other site
251221004490	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
251221004491	DCoH tetramer interaction site [polypeptide binding]; other site
251221004492	substrate binding site [chemical binding]; other site
251221004493	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
251221004494	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
251221004495	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
251221004496	catalytic loop [active]
251221004497	iron binding site [ion binding]; other site
251221004498	Ycf46; Provisional; Region: ycf46; CHL00195
251221004499	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221004500	Walker A motif; other site
251221004501	ATP binding site [chemical binding]; other site
251221004502	Walker B motif; other site
251221004503	arginine finger; other site
251221004504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004505	TPR repeat; Region: TPR_11; pfam13414
251221004506	binding surface
251221004507	TPR motif; other site
251221004508	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004509	binding surface
251221004510	TPR motif; other site
251221004511	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004512	TPR repeat; Region: TPR_11; pfam13414
251221004513	binding surface
251221004514	TPR motif; other site
251221004515	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
251221004516	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221004517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004518	S-adenosylmethionine binding site [chemical binding]; other site
251221004519	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
251221004520	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
251221004521	Verru_Chthon cassette protein D; Region: TIGR02596
251221004522	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
251221004523	GAF domain; Region: GAF_2; pfam13185
251221004524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004525	TPR motif; other site
251221004526	binding surface
251221004527	TPR repeat; Region: TPR_11; pfam13414
251221004528	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
251221004529	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
251221004530	Active Sites [active]
251221004531	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
251221004532	active site
251221004533	dimer interface [polypeptide binding]; other site
251221004534	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
251221004535	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
251221004536	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
251221004537	active site
251221004538	(T/H)XGH motif; other site
251221004539	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
251221004540	nudix motif; other site
251221004541	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221004542	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221004543	ligand binding site [chemical binding]; other site
251221004544	flexible hinge region; other site
251221004545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004546	ATP binding site [chemical binding]; other site
251221004547	Mg2+ binding site [ion binding]; other site
251221004548	G-X-G motif; other site
251221004549	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221004550	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221004551	ligand binding site [chemical binding]; other site
251221004552	flexible hinge region; other site
251221004553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004554	ATP binding site [chemical binding]; other site
251221004555	Mg2+ binding site [ion binding]; other site
251221004556	G-X-G motif; other site
251221004557	Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275
251221004558	active site
251221004559	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
251221004560	EVE domain; Region: EVE; cl00728
251221004561	amino acid transporter; Region: 2A0306; TIGR00909
251221004562	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
251221004563	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
251221004564	muropeptide transporter; Reviewed; Region: ampG; cl17669
251221004565	Major Facilitator Superfamily; Region: MFS_1; pfam07690
251221004566	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
251221004567	active site
251221004568	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
251221004569	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
251221004570	active site
251221004571	homodimer interface [polypeptide binding]; other site
251221004572	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
251221004573	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
251221004574	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
251221004575	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
251221004576	Na binding site [ion binding]; other site
251221004577	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
251221004578	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221004579	putative active site [active]
251221004580	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
251221004581	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
251221004582	nucleotide binding site [chemical binding]; other site
251221004583	putative NEF/HSP70 interaction site [polypeptide binding]; other site
251221004584	SBD interface [polypeptide binding]; other site
251221004585	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
251221004586	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
251221004587	oligomeric interface; other site
251221004588	putative active site [active]
251221004589	homodimer interface [polypeptide binding]; other site
251221004590	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
251221004591	putative active site [active]
251221004592	homotetrameric interface [polypeptide binding]; other site
251221004593	metal binding site [ion binding]; metal-binding site
251221004594	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
251221004595	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
251221004596	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
251221004597	putative active site; other site
251221004598	catalytic triad [active]
251221004599	putative dimer interface [polypeptide binding]; other site
251221004600	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221004601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221004602	active site
251221004603	phosphorylation site [posttranslational modification]
251221004604	intermolecular recognition site; other site
251221004605	dimerization interface [polypeptide binding]; other site
251221004606	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221004607	DNA binding residues [nucleotide binding]
251221004608	dimerization interface [polypeptide binding]; other site
251221004609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221004610	active site
251221004611	phosphorylation site [posttranslational modification]
251221004612	intermolecular recognition site; other site
251221004613	dimerization interface [polypeptide binding]; other site
251221004614	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
251221004615	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
251221004616	Zn2+ binding site [ion binding]; other site
251221004617	Mg2+ binding site [ion binding]; other site
251221004618	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
251221004619	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221004620	dimer interface [polypeptide binding]; other site
251221004621	phosphorylation site [posttranslational modification]
251221004622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004623	ATP binding site [chemical binding]; other site
251221004624	Mg2+ binding site [ion binding]; other site
251221004625	G-X-G motif; other site
251221004626	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
251221004627	dimer interface [polypeptide binding]; other site
251221004628	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
251221004629	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
251221004630	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
251221004631	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
251221004632	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
251221004633	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
251221004634	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
251221004635	active site
251221004636	dimer interface [polypeptide binding]; other site
251221004637	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
251221004638	dimer interface [polypeptide binding]; other site
251221004639	active site
251221004640	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
251221004641	ABC-ATPase subunit  interface; other site
251221004642	dimer interface [polypeptide binding]; other site
251221004643	putative PBP binding regions; other site
251221004644	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
251221004645	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
251221004646	intersubunit interface [polypeptide binding]; other site
251221004647	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
251221004648	putative active site [active]
251221004649	Ion channel; Region: Ion_trans_2; pfam07885
251221004650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004651	S-adenosylmethionine binding site [chemical binding]; other site
251221004652	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
251221004653	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
251221004654	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
251221004655	putative dimer interface [polypeptide binding]; other site
251221004656	N-terminal domain interface [polypeptide binding]; other site
251221004657	putative substrate binding pocket (H-site) [chemical binding]; other site
251221004658	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221004659	putative active site [active]
251221004660	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
251221004661	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
251221004662	C-terminal domain interface [polypeptide binding]; other site
251221004663	GSH binding site (G-site) [chemical binding]; other site
251221004664	dimer interface [polypeptide binding]; other site
251221004665	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
251221004666	N-terminal domain interface [polypeptide binding]; other site
251221004667	putative dimer interface [polypeptide binding]; other site
251221004668	active site
251221004669	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
251221004670	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
251221004671	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
251221004672	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221004673	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
251221004674	pheophytin binding site; other site
251221004675	chlorophyll binding site; other site
251221004676	quinone binding site; other site
251221004677	Fe binding site [ion binding]; other site
251221004678	YceI-like domain; Region: YceI; pfam04264
251221004679	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
251221004680	putative active site [active]
251221004681	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
251221004682	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
251221004683	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221004684	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
251221004685	Peptidase family M50; Region: Peptidase_M50; pfam02163
251221004686	active site
251221004687	putative substrate binding region [chemical binding]; other site
251221004688	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
251221004689	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221004690	Walker A motif; other site
251221004691	ATP binding site [chemical binding]; other site
251221004692	Walker B motif; other site
251221004693	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cl00230
251221004694	arginine finger; other site
251221004695	YciI-like protein; Reviewed; Region: PRK12864
251221004696	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
251221004697	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
251221004698	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
251221004699	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
251221004700	catalytic residues [active]
251221004701	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
251221004702	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
251221004703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221004704	NAD(P) binding site [chemical binding]; other site
251221004705	Helix-turn-helix domain; Region: HTH_17; cl17695
251221004706	PIN domain; Region: PIN_3; pfam13470
251221004707	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221004708	Predicted transcriptional regulators [Transcription]; Region: COG1695
251221004709	Homeodomain-like domain; Region: HTH_23; cl17451
251221004710	Winged helix-turn helix; Region: HTH_29; pfam13551
251221004711	DDE superfamily endonuclease; Region: DDE_3; pfam13358
251221004712	Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments...; Region: CrtW_beta-carotene-ketolase; cd03513
251221004713	putative di-iron ligands [ion binding]; other site
251221004714	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
251221004715	active site
251221004716	catalytic residues [active]
251221004717	metal binding site [ion binding]; metal-binding site
251221004718	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
251221004719	TM-ABC transporter signature motif; other site
251221004720	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
251221004721	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
251221004722	putative active site [active]
251221004723	catalytic triad [active]
251221004724	putative dimer interface [polypeptide binding]; other site
251221004725	TPR repeat; Region: TPR_11; pfam13414
251221004726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221004727	binding surface
251221004728	TPR motif; other site
251221004729	TPR repeat; Region: TPR_11; pfam13414
251221004730	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
251221004731	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
251221004732	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
251221004733	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
251221004734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221004735	Coenzyme A binding pocket [chemical binding]; other site
251221004736	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
251221004737	Putative zinc-finger; Region: zf-HC2; pfam13490
251221004738	putative anti-sigmaE protein; Provisional; Region: PRK13920
251221004739	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
251221004740	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221004741	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221004742	DNA binding residues [nucleotide binding]
251221004743	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
251221004744	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
251221004745	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876
251221004746	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
251221004747	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
251221004748	active site lid residues [active]
251221004749	substrate binding pocket [chemical binding]; other site
251221004750	catalytic residues [active]
251221004751	substrate-Mg2+ binding site; other site
251221004752	aspartate-rich region 1; other site
251221004753	aspartate-rich region 2; other site
251221004754	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
251221004755	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
251221004756	MMPL family; Region: MMPL; cl14618
251221004757	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
251221004758	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
251221004759	putative NADP binding site [chemical binding]; other site
251221004760	putative substrate binding site [chemical binding]; other site
251221004761	active site
251221004762	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
251221004763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221004764	FeS/SAM binding site; other site
251221004765	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
251221004766	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
251221004767	DNA photolyase; Region: DNA_photolyase; pfam00875
251221004768	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
251221004769	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
251221004770	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
251221004771	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
251221004772	N- and C-terminal domain interface [polypeptide binding]; other site
251221004773	active site
251221004774	MgATP binding site [chemical binding]; other site
251221004775	catalytic site [active]
251221004776	metal binding site [ion binding]; metal-binding site
251221004777	glycerol binding site [chemical binding]; other site
251221004778	homotetramer interface [polypeptide binding]; other site
251221004779	homodimer interface [polypeptide binding]; other site
251221004780	FBP binding site [chemical binding]; other site
251221004781	protein IIAGlc interface [polypeptide binding]; other site
251221004782	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
251221004783	catalytic core [active]
251221004784	Tic22-like family; Region: Tic22; pfam04278
251221004785	Tic22-like family; Region: Tic22; pfam04278
251221004786	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
251221004787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221004788	S-adenosylmethionine binding site [chemical binding]; other site
251221004789	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
251221004790	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
251221004791	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
251221004792	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221004793	Serine hydrolase; Region: Ser_hydrolase; cl17834
251221004794	Serine hydrolase (FSH1); Region: FSH1; pfam03959
251221004795	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
251221004796	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
251221004797	homodimer interface [polypeptide binding]; other site
251221004798	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
251221004799	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
251221004800	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
251221004801	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
251221004802	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
251221004803	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
251221004804	nucleoside/Zn binding site; other site
251221004805	dimer interface [polypeptide binding]; other site
251221004806	catalytic motif [active]
251221004807	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
251221004808	RNA polymerase sigma factor; Provisional; Region: PRK12519
251221004809	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221004810	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221004811	DNA binding residues [nucleotide binding]
251221004812	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
251221004813	Anti-sigma-K factor rskA; Region: RskA; pfam10099
251221004814	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
251221004815	PAS fold; Region: PAS_4; pfam08448
251221004816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221004817	putative active site [active]
251221004818	heme pocket [chemical binding]; other site
251221004819	GAF domain; Region: GAF; pfam01590
251221004820	PAS fold; Region: PAS_4; pfam08448
251221004821	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221004822	putative active site [active]
251221004823	heme pocket [chemical binding]; other site
251221004824	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
251221004825	Histidine kinase; Region: HisKA_2; pfam07568
251221004826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004827	ATP binding site [chemical binding]; other site
251221004828	Mg2+ binding site [ion binding]; other site
251221004829	G-X-G motif; other site
251221004830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221004831	active site
251221004832	phosphorylation site [posttranslational modification]
251221004833	intermolecular recognition site; other site
251221004834	dimerization interface [polypeptide binding]; other site
251221004835	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221004836	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
251221004837	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
251221004838	putative switch regulator; other site
251221004839	non-specific DNA interactions [nucleotide binding]; other site
251221004840	DNA binding site [nucleotide binding]
251221004841	sequence specific DNA binding site [nucleotide binding]; other site
251221004842	putative cAMP binding site [chemical binding]; other site
251221004843	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
251221004844	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
251221004845	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
251221004846	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
251221004847	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
251221004848	ATP-grasp domain; Region: ATP-grasp_4; cl17255
251221004849	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
251221004850	IMP binding site; other site
251221004851	dimer interface [polypeptide binding]; other site
251221004852	partial ornithine binding site; other site
251221004853	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
251221004854	putative active site [active]
251221004855	cobyric acid synthase; Provisional; Region: PRK00784
251221004856	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221004857	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
251221004858	catalytic triad [active]
251221004859	aspartate kinase; Provisional; Region: PRK07431
251221004860	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
251221004861	putative nucleotide binding site [chemical binding]; other site
251221004862	putative catalytic residues [active]
251221004863	putative Mg ion binding site [ion binding]; other site
251221004864	putative aspartate binding site [chemical binding]; other site
251221004865	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
251221004866	putative allosteric regulatory site; other site
251221004867	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
251221004868	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
251221004869	putative allosteric regulatory site; other site
251221004870	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
251221004871	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
251221004872	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
251221004873	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
251221004874	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
251221004875	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
251221004876	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
251221004877	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
251221004878	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
251221004879	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
251221004880	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221004881	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
251221004882	UDP-N-acetylenolpyruvoylglucosamine reductase; Region: murB; TIGR00179
251221004883	FAD binding domain; Region: FAD_binding_4; cl19922
251221004884	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
251221004885	colanic acid exporter; Provisional; Region: PRK10459
251221004886	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
251221004887	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
251221004888	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
251221004889	active site
251221004890	Substrate binding site; other site
251221004891	Mg++ binding site; other site
251221004892	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221004893	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
251221004894	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
251221004895	substrate binding site; other site
251221004896	tetramer interface; other site
251221004897	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
251221004898	serine O-acetyltransferase; Region: cysE; TIGR01172
251221004899	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
251221004900	trimer interface [polypeptide binding]; other site
251221004901	active site
251221004902	substrate binding site [chemical binding]; other site
251221004903	CoA binding site [chemical binding]; other site
251221004904	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221004905	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221004906	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
251221004907	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221004908	IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603
251221004909	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221004910	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221004911	IPT/TIG domain; Region: TIG; pfam01833
251221004912	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221004913	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
251221004914	Bacterial sugar transferase; Region: Bac_transf; pfam02397
251221004915	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
251221004916	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
251221004917	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221004918	active site
251221004919	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
251221004920	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
251221004921	Chain length determinant protein; Region: Wzz; pfam02706
251221004922	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
251221004923	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
251221004924	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221004925	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
251221004926	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
251221004927	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
251221004928	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
251221004929	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
251221004930	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
251221004931	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221004932	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221004933	DNA binding residues [nucleotide binding]
251221004934	dimerization interface [polypeptide binding]; other site
251221004935	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221004936	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
251221004937	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
251221004938	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
251221004939	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
251221004940	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
251221004941	Pantoate-beta-alanine ligase; Region: PanC; cd00560
251221004942	active site
251221004943	ATP-binding site [chemical binding]; other site
251221004944	pantoate-binding site; other site
251221004945	HXXH motif; other site
251221004946	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
251221004947	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
251221004948	active site
251221004949	CMP-binding site; other site
251221004950	The sites determining sugar specificity; other site
251221004951	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
251221004952	ThiS interaction site; other site
251221004953	putative active site [active]
251221004954	tetramer interface [polypeptide binding]; other site
251221004955	Transposase; Region: HTH_Tnp_1; cl17663
251221004956	Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958
251221004957	putative active site [active]
251221004958	Permease; Region: Permease; cl00510
251221004959	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221004960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221004961	active site
251221004962	phosphorylation site [posttranslational modification]
251221004963	intermolecular recognition site; other site
251221004964	dimerization interface [polypeptide binding]; other site
251221004965	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221004966	DNA binding site [nucleotide binding]
251221004967	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
251221004968	P33 mono-oxygenase; Region: P33MONOX; pfam15302
251221004969	NnrS protein; Region: NnrS; cl01258
251221004970	ribonuclease E; Reviewed; Region: rne; PRK10811
251221004971	heat shock protein 90; Provisional; Region: PRK05218
251221004972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004973	ATP binding site [chemical binding]; other site
251221004974	Mg2+ binding site [ion binding]; other site
251221004975	G-X-G motif; other site
251221004976	Hsp90 protein; Region: HSP90; pfam00183
251221004977	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
251221004978	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
251221004979	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
251221004980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221004981	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221004982	dimer interface [polypeptide binding]; other site
251221004983	phosphorylation site [posttranslational modification]
251221004984	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221004985	ATP binding site [chemical binding]; other site
251221004986	Mg2+ binding site [ion binding]; other site
251221004987	G-X-G motif; other site
251221004988	maltose O-acetyltransferase; Provisional; Region: PRK10092
251221004989	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
251221004990	active site
251221004991	substrate binding site [chemical binding]; other site
251221004992	trimer interface [polypeptide binding]; other site
251221004993	CoA binding site [chemical binding]; other site
251221004994	methionine sulfoxide reductase A; Provisional; Region: PRK13014
251221004995	kinase; Region: PLN02967
251221004996	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
251221004997	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
251221004998	minor groove reading motif; other site
251221004999	helix-hairpin-helix signature motif; other site
251221005000	substrate binding pocket [chemical binding]; other site
251221005001	active site
251221005002	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221005003	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
251221005004	Pirin-related protein [General function prediction only]; Region: COG1741
251221005005	Pirin; Region: Pirin; pfam02678
251221005006	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
251221005007	Predicted transcriptional regulator [Transcription]; Region: COG3905
251221005008	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
251221005009	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
251221005010	conserved cys residue [active]
251221005011	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
251221005012	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
251221005013	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
251221005014	ligand binding site [chemical binding]; other site
251221005015	elongation factor Ts; Reviewed; Region: tsf; PRK12332
251221005016	UBA/TS-N domain; Region: UBA; pfam00627
251221005017	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
251221005018	rRNA interaction site [nucleotide binding]; other site
251221005019	S8 interaction site; other site
251221005020	putative laminin-1 binding site; other site
251221005021	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
251221005022	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
251221005023	putative active site [active]
251221005024	substrate binding site [chemical binding]; other site
251221005025	putative cosubstrate binding site; other site
251221005026	catalytic site [active]
251221005027	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
251221005028	substrate binding site [chemical binding]; other site
251221005029	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221005030	Ligand Binding Site [chemical binding]; other site
251221005031	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221005032	Ligand Binding Site [chemical binding]; other site
251221005033	Domain of unknown function DUF21; Region: DUF21; pfam01595
251221005034	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
251221005035	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
251221005036	Transporter associated domain; Region: CorC_HlyC; smart01091
251221005037	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
251221005038	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221005039	ATP binding site [chemical binding]; other site
251221005040	putative Mg++ binding site [ion binding]; other site
251221005041	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
251221005042	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
251221005043	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
251221005044	zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
251221005045	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
251221005046	Transposase; Region: DDE_Tnp_ISL3; pfam01610
251221005047	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
251221005048	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
251221005049	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221005050	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221005051	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221005052	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221005053	Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191
251221005054	TIGR03032 family protein; Region: TIGR03032
251221005055	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
251221005056	Predicted ATPase [General function prediction only]; Region: COG4637
251221005057	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221005058	Walker A/P-loop; other site
251221005059	ATP binding site [chemical binding]; other site
251221005060	Q-loop/lid; other site
251221005061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
251221005062	ABC transporter signature motif; other site
251221005063	Walker B; other site
251221005064	D-loop; other site
251221005065	H-loop/switch region; other site
251221005066	Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401
251221005067	prohibitin homologues; Region: PHB; smart00244
251221005068	Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401
251221005069	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
251221005070	reactive center loop; other site
251221005071	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
251221005072	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
251221005073	sulfite reductase subunit beta; Provisional; Region: PRK13504
251221005074	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
251221005075	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
251221005076	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
251221005077	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
251221005078	CAAX protease self-immunity; Region: Abi; pfam02517
251221005079	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
251221005080	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
251221005081	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
251221005082	CheB methylesterase; Region: CheB_methylest; pfam01339
251221005083	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
251221005084	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
251221005085	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
251221005086	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
251221005087	PAS domain; Region: PAS_10; pfam13596
251221005088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221005089	putative active site [active]
251221005090	heme pocket [chemical binding]; other site
251221005091	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
251221005092	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221005093	dimer interface [polypeptide binding]; other site
251221005094	phosphorylation site [posttranslational modification]
251221005095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221005096	ATP binding site [chemical binding]; other site
251221005097	Mg2+ binding site [ion binding]; other site
251221005098	G-X-G motif; other site
251221005099	excinuclease ABC subunit B; Provisional; Region: PRK05298
251221005100	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221005101	ATP binding site [chemical binding]; other site
251221005102	Striatin family; Region: Striatin; pfam08232
251221005103	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221005104	nucleotide binding region [chemical binding]; other site
251221005105	ATP-binding site [chemical binding]; other site
251221005106	Ultra-violet resistance protein B; Region: UvrB; pfam12344
251221005107	UvrB/uvrC motif; Region: UVR; pfam02151
251221005108	ScpA/B protein; Region: ScpA_ScpB; cl00598
251221005109	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
251221005110	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
251221005111	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
251221005112	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
251221005113	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
251221005114	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
251221005115	inhibitor-cofactor binding pocket; inhibition site
251221005116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221005117	catalytic residue [active]
251221005118	Bifunctional nuclease; Region: DNase-RNase; pfam02577
251221005119	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
251221005120	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
251221005121	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
251221005122	Surface antigen; Region: Bac_surface_Ag; pfam01103
251221005123	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
251221005124	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
251221005125	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
251221005126	trimer interface [polypeptide binding]; other site
251221005127	active site
251221005128	UDP-GlcNAc binding site [chemical binding]; other site
251221005129	lipid binding site [chemical binding]; lipid-binding site
251221005130	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
251221005131	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
251221005132	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
251221005133	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
251221005134	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
251221005135	active site
251221005136	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
251221005137	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
251221005138	intrachain domain interface; other site
251221005139	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
251221005140	Qo binding site; other site
251221005141	heme bH binding site [chemical binding]; other site
251221005142	Qi binding site; other site
251221005143	intrachain domain interface; other site
251221005144	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
251221005145	heme bL binding site [chemical binding]; other site
251221005146	interchain domain interface [polypeptide binding]; other site
251221005147	Qo binding site; other site
251221005148	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
251221005149	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
251221005150	active site
251221005151	metal binding site [ion binding]; metal-binding site
251221005152	hexamer interface [polypeptide binding]; other site
251221005153	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
251221005154	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
251221005155	catalytic core [active]
251221005156	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
251221005157	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
251221005158	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
251221005159	Competence protein; Region: Competence; pfam03772
251221005160	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
251221005161	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774
251221005162	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
251221005163	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
251221005164	molybdopterin cofactor binding site; other site
251221005165	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
251221005166	molybdopterin cofactor binding site; other site
251221005167	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221005168	putative active site [active]
251221005169	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
251221005170	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
251221005171	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
251221005172	homodimer interface [polypeptide binding]; other site
251221005173	NADP binding site [chemical binding]; other site
251221005174	substrate binding site [chemical binding]; other site
251221005175	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221005176	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221005177	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221005178	Tetratricopeptide repeat; Region: TPR_10; pfam13374
251221005179	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221005180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221005181	binding surface
251221005182	TPR motif; other site
251221005183	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221005184	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221005185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221005186	binding surface
251221005187	TPR motif; other site
251221005188	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221005189	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221005190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221005191	binding surface
251221005192	TPR motif; other site
251221005193	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221005194	CHAT domain; Region: CHAT; pfam12770
251221005195	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
251221005196	active site
251221005197	catalytic triad [active]
251221005198	oxyanion hole [active]
251221005199	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
251221005200	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
251221005201	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
251221005202	C-terminal domain interface [polypeptide binding]; other site
251221005203	GSH binding site (G-site) [chemical binding]; other site
251221005204	dimer interface [polypeptide binding]; other site
251221005205	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
251221005206	N-terminal domain interface [polypeptide binding]; other site
251221005207	dimer interface [polypeptide binding]; other site
251221005208	substrate binding pocket (H-site) [chemical binding]; other site
251221005209	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221005210	active site
251221005211	catalytic tetrad [active]
251221005212	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
251221005213	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221005214	putative active site [active]
251221005215	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
251221005216	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
251221005217	active site
251221005218	iron coordination sites [ion binding]; other site
251221005219	substrate binding pocket [chemical binding]; other site
251221005220	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
251221005221	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
251221005222	Tetratricopeptide repeat; Region: TPR_16; pfam13432
251221005223	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221005224	binding surface
251221005225	TPR motif; other site
251221005226	TPR repeat; Region: TPR_11; pfam13414
251221005227	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221005228	binding surface
251221005229	TPR motif; other site
251221005230	Tetratricopeptide repeat; Region: TPR_16; pfam13432
251221005231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221005232	TPR motif; other site
251221005233	binding surface
251221005234	Tetratricopeptide repeat; Region: TPR_19; pfam14559
251221005235	Sulfatase; Region: Sulfatase; cl19157
251221005236	HlyD family secretion protein; Region: HlyD; pfam00529
251221005237	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221005238	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
251221005239	NHL repeat; Region: NHL; pfam01436
251221005240	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
251221005241	Cytochrome c; Region: Cytochrom_C; cl11414
251221005242	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221005243	putative active site [active]
251221005244	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221005245	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221005246	N-terminal plug; other site
251221005247	ligand-binding site [chemical binding]; other site
251221005248	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
251221005249	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
251221005250	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
251221005251	Haemolytic domain; Region: Haemolytic; pfam01809
251221005252	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
251221005253	patatin-related protein; Region: TIGR03607
251221005254	Patatin-like phospholipase; Region: Patatin; pfam01734
251221005255	active site
251221005256	nucleophile elbow; other site
251221005257	Protein of unknown function (DUF3376); Region: DUF3376; pfam11856
251221005258	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
251221005259	ATP binding site [chemical binding]; other site
251221005260	active site
251221005261	substrate binding site [chemical binding]; other site
251221005262	FtsH Extracellular; Region: FtsH_ext; pfam06480
251221005263	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
251221005264	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221005265	Walker A motif; other site
251221005266	ATP binding site [chemical binding]; other site
251221005267	Walker B motif; other site
251221005268	arginine finger; other site
251221005269	Peptidase family M41; Region: Peptidase_M41; pfam01434
251221005270	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
251221005271	interchain domain interface [polypeptide binding]; other site
251221005272	intrachain domain interface; other site
251221005273	Qi binding site; other site
251221005274	Qo binding site; other site
251221005275	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
251221005276	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
251221005277	Qi binding site; other site
251221005278	intrachain domain interface; other site
251221005279	interchain domain interface [polypeptide binding]; other site
251221005280	heme bH binding site [chemical binding]; other site
251221005281	heme bL binding site [chemical binding]; other site
251221005282	Qo binding site; other site
251221005283	Predicted transcriptional regulator [Transcription]; Region: COG1959
251221005284	Rrf2 family protein; Region: rrf2_super; TIGR00738
251221005285	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
251221005286	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
251221005287	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
251221005288	iron-sulfur cluster [ion binding]; other site
251221005289	[2Fe-2S] cluster binding site [ion binding]; other site
251221005290	Uncharacterized conserved protein [Function unknown]; Region: COG3349
251221005291	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
251221005292	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
251221005293	iron-sulfur cluster [ion binding]; other site
251221005294	[2Fe-2S] cluster binding site [ion binding]; other site
251221005295	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
251221005296	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221005297	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
251221005298	active site
251221005299	catalytic tetrad [active]
251221005300	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
251221005301	MgtE intracellular N domain; Region: MgtE_N; smart00924
251221005302	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
251221005303	Divalent cation transporter; Region: MgtE; cl00786
251221005304	Predicted ATPase [General function prediction only]; Region: COG4637
251221005305	AAA domain; Region: AAA_23; pfam13476
251221005306	AAA domain; Region: AAA_21; pfam13304
251221005307	Walker A/P-loop; other site
251221005308	ATP binding site [chemical binding]; other site
251221005309	Q-loop/lid; other site
251221005310	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
251221005311	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
251221005312	dimer interface [polypeptide binding]; other site
251221005313	anticodon binding site; other site
251221005314	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
251221005315	homodimer interface [polypeptide binding]; other site
251221005316	motif 1; other site
251221005317	active site
251221005318	motif 2; other site
251221005319	GAD domain; Region: GAD; pfam02938
251221005320	motif 3; other site
251221005321	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
251221005322	Phycobilisome protein; Region: Phycobilisome; cl08227
251221005323	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
251221005324	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
251221005325	Uncharacterized conserved protein [Function unknown]; Region: COG3391
251221005326	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
251221005327	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
251221005328	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005329	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005330	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005331	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005332	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
251221005333	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221005334	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
251221005335	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
251221005336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221005337	S-adenosylmethionine binding site [chemical binding]; other site
251221005338	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
251221005339	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
251221005340	Di-iron ligands [ion binding]; other site
251221005341	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
251221005342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221005343	S-adenosylmethionine binding site [chemical binding]; other site
251221005344	SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109
251221005345	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
251221005346	Di-iron ligands [ion binding]; other site
251221005347	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221005348	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
251221005349	active site
251221005350	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
251221005351	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
251221005352	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221005353	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
251221005354	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
251221005355	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221005356	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
251221005357	active site
251221005358	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
251221005359	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
251221005360	Di-iron ligands [ion binding]; other site
251221005361	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
251221005362	Di-iron ligands [ion binding]; other site
251221005363	acyl-CoA synthetase; Validated; Region: PRK05850
251221005364	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
251221005365	acyl-activating enzyme (AAE) consensus motif; other site
251221005366	active site
251221005367	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
251221005368	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
251221005369	putative NAD(P) binding site [chemical binding]; other site
251221005370	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
251221005371	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
251221005372	acyl-activating enzyme (AAE) consensus motif; other site
251221005373	putative AMP binding site [chemical binding]; other site
251221005374	putative active site [active]
251221005375	putative CoA binding site [chemical binding]; other site
251221005376	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
251221005377	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
251221005378	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221005379	acyl-CoA synthetase; Validated; Region: PRK05850
251221005380	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
251221005381	acyl-activating enzyme (AAE) consensus motif; other site
251221005382	active site
251221005383	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
251221005384	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221005385	active site
251221005386	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
251221005387	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
251221005388	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
251221005389	short chain dehydrogenase; Region: adh_short; pfam00106
251221005390	putative NADP binding site [chemical binding]; other site
251221005391	active site
251221005392	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
251221005393	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
251221005394	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221005395	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
251221005396	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
251221005397	FMN binding site [chemical binding]; other site
251221005398	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
251221005399	substrate binding site [chemical binding]; other site
251221005400	putative catalytic residue [active]
251221005401	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221005402	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
251221005403	active site
251221005404	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
251221005405	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221005406	active site
251221005407	Acyl transferase domain; Region: Acyl_transf_1; cl08282
251221005408	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
251221005409	putative NADP binding site [chemical binding]; other site
251221005410	active site
251221005411	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
251221005412	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221005413	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
251221005414	active site
251221005415	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
251221005416	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
251221005417	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
251221005418	active site
251221005419	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221005420	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221005421	N-terminal plug; other site
251221005422	ligand-binding site [chemical binding]; other site
251221005423	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
251221005424	active site
251221005425	metal binding site [ion binding]; metal-binding site
251221005426	Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743
251221005427	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221005428	AAA ATPase domain; Region: AAA_16; pfam13191
251221005429	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
251221005430	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221005431	structural tetrad; other site
251221005432	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221005433	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221005434	structural tetrad; other site
251221005435	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221005436	structural tetrad; other site
251221005437	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
251221005438	active site
251221005439	Domain of unknown function (DUF427); Region: DUF427; pfam04248
251221005440	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
251221005441	reactive center loop; other site
251221005442	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221005443	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
251221005444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221005445	Coenzyme A binding pocket [chemical binding]; other site
251221005446	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
251221005447	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221005448	N-terminal plug; other site
251221005449	ligand-binding site [chemical binding]; other site
251221005450	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
251221005451	dimer interface [polypeptide binding]; other site
251221005452	[2Fe-2S] cluster binding site [ion binding]; other site
251221005453	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
251221005454	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005455	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005456	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005457	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005458	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221005459	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221005460	N-terminal plug; other site
251221005461	ligand-binding site [chemical binding]; other site
251221005462	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
251221005463	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
251221005464	conserved cys residue [active]
251221005465	Cytochrome c; Region: Cytochrom_C; cl11414
251221005466	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
251221005467	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
251221005468	E-class dimer interface [polypeptide binding]; other site
251221005469	P-class dimer interface [polypeptide binding]; other site
251221005470	active site
251221005471	Cu2+ binding site [ion binding]; other site
251221005472	Zn2+ binding site [ion binding]; other site
251221005473	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221005474	Ligand Binding Site [chemical binding]; other site
251221005475	phosphoenolpyruvate synthase; Validated; Region: PRK06464
251221005476	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
251221005477	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
251221005478	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
251221005479	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
251221005480	EamA-like transporter family; Region: EamA; pfam00892
251221005481	EamA-like transporter family; Region: EamA; pfam00892
251221005482	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
251221005483	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005484	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
251221005485	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
251221005486	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
251221005487	active site
251221005488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221005489	S-adenosylmethionine binding site [chemical binding]; other site
251221005490	septum formation inhibitor; Reviewed; Region: minC; PRK00513
251221005491	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
251221005492	septum site-determining protein MinD; Region: minD_bact; TIGR01968
251221005493	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
251221005494	P-loop; other site
251221005495	ADP binding residues [chemical binding]; other site
251221005496	Switch I; other site
251221005497	Switch II; other site
251221005498	Septum formation topological specificity factor MinE; Region: MinE; cl00538
251221005499	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
251221005500	Soluble P-type ATPase [General function prediction only]; Region: COG4087
251221005501	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
251221005502	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221005503	pyruvate kinase; Validated; Region: PRK08187
251221005504	Pyruvate kinase, barrel domain; Region: PK; cl17342
251221005505	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
251221005506	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
251221005507	Walker A/P-loop; other site
251221005508	ATP binding site [chemical binding]; other site
251221005509	Q-loop/lid; other site
251221005510	ABC transporter signature motif; other site
251221005511	Walker B; other site
251221005512	D-loop; other site
251221005513	H-loop/switch region; other site
251221005514	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221005515	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221005516	TAP-like protein; Region: Abhydrolase_4; pfam08386
251221005517	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
251221005518	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
251221005519	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221005520	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
251221005521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221005522	oxidoreductase; Provisional; Region: PRK06128
251221005523	NAD(P) binding site [chemical binding]; other site
251221005524	active site
251221005525	Transposase [DNA replication, recombination, and repair]; Region: COG5433
251221005526	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
251221005527	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
251221005528	acyl-activating enzyme (AAE) consensus motif; other site
251221005529	active site
251221005530	AMP binding site [chemical binding]; other site
251221005531	CoA binding site [chemical binding]; other site
251221005532	Helix-turn-helix domain; Region: HTH_38; pfam13936
251221005533	Winged helix-turn helix; Region: HTH_29; pfam13551
251221005534	Homeodomain-like domain; Region: HTH_32; pfam13565
251221005535	Integrase core domain; Region: rve; pfam00665
251221005536	Esterase/lipase [General function prediction only]; Region: COG1647
251221005537	YGGT family; Region: YGGT; pfam02325
251221005538	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
251221005539	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
251221005540	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
251221005541	trimer interface [polypeptide binding]; other site
251221005542	active site
251221005543	UDP-GlcNAc binding site [chemical binding]; other site
251221005544	lipid binding site [chemical binding]; lipid-binding site
251221005545	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
251221005546	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
251221005547	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
251221005548	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
251221005549	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221005550	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221005551	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221005552	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221005553	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
251221005554	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221005555	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221005556	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
251221005557	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
251221005558	Walker A/P-loop; other site
251221005559	ATP binding site [chemical binding]; other site
251221005560	Q-loop/lid; other site
251221005561	ABC transporter signature motif; other site
251221005562	Walker B; other site
251221005563	D-loop; other site
251221005564	H-loop/switch region; other site
251221005565	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
251221005566	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
251221005567	Walker A/P-loop; other site
251221005568	ATP binding site [chemical binding]; other site
251221005569	Q-loop/lid; other site
251221005570	ABC transporter signature motif; other site
251221005571	Walker B; other site
251221005572	D-loop; other site
251221005573	H-loop/switch region; other site
251221005574	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
251221005575	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
251221005576	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
251221005577	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
251221005578	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
251221005579	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
251221005580	minor groove reading motif; other site
251221005581	helix-hairpin-helix signature motif; other site
251221005582	substrate binding pocket [chemical binding]; other site
251221005583	active site
251221005584	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063
251221005585	ResB-like family; Region: ResB; pfam05140
251221005586	cytochrome c biogenesis protein; Region: ccsA; CHL00045
251221005587	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
251221005588	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
251221005589	Catalytic site [active]
251221005590	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
251221005591	putative active site [active]
251221005592	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
251221005593	Uncharacterized conserved protein [Function unknown]; Region: COG2442
251221005594	Penicillinase repressor; Region: Penicillinase_R; pfam03965
251221005595	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
251221005596	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
251221005597	Outer membrane efflux protein; Region: OEP; pfam02321
251221005598	Outer membrane efflux protein; Region: OEP; pfam02321
251221005599	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221005600	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221005601	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
251221005602	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221005603	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
251221005604	MMPL family; Region: MMPL; cl14618
251221005605	MMPL family; Region: MMPL; cl14618
251221005606	FixH; Region: FixH; cl19376
251221005607	FixH; Region: FixH; cl19376
251221005608	Integrin, beta chain; Region: Integrin_beta; cl17693
251221005609	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
251221005610	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
251221005611	putative homodimer interface [polypeptide binding]; other site
251221005612	putative homotetramer interface [polypeptide binding]; other site
251221005613	putative allosteric switch controlling residues; other site
251221005614	putative metal binding site [ion binding]; other site
251221005615	putative homodimer-homodimer interface [polypeptide binding]; other site
251221005616	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323
251221005617	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
251221005618	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
251221005619	Walker A motif; other site
251221005620	ATP binding site [chemical binding]; other site
251221005621	Walker B motif; other site
251221005622	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
251221005623	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
251221005624	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221005625	hypothetical protein; Provisional; Region: PRK08317
251221005626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221005627	S-adenosylmethionine binding site [chemical binding]; other site
251221005628	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
251221005629	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
251221005630	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
251221005631	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
251221005632	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
251221005633	Ligand Binding Site [chemical binding]; other site
251221005634	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
251221005635	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
251221005636	active site
251221005637	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221005638	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
251221005639	NAD(P) binding site [chemical binding]; other site
251221005640	active site
251221005641	DNA gyrase subunit A; Validated; Region: PRK05560
251221005642	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
251221005643	CAP-like domain; other site
251221005644	active site
251221005645	primary dimer interface [polypeptide binding]; other site
251221005646	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221005647	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221005648	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221005649	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
251221005650	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221005651	N-terminal plug; other site
251221005652	ligand-binding site [chemical binding]; other site
251221005653	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
251221005654	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
251221005655	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
251221005656	Walker A/P-loop; other site
251221005657	ATP binding site [chemical binding]; other site
251221005658	Q-loop/lid; other site
251221005659	ABC transporter signature motif; other site
251221005660	Walker B; other site
251221005661	D-loop; other site
251221005662	H-loop/switch region; other site
251221005663	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
251221005664	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
251221005665	Walker A/P-loop; other site
251221005666	ATP binding site [chemical binding]; other site
251221005667	Q-loop/lid; other site
251221005668	ABC transporter signature motif; other site
251221005669	Walker B; other site
251221005670	D-loop; other site
251221005671	H-loop/switch region; other site
251221005672	Leucine carboxyl methyltransferase; Region: LCM; cl01306
251221005673	putative high light inducible protein; Region: PHA02337
251221005674	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
251221005675	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
251221005676	dimer interface [polypeptide binding]; other site
251221005677	PYR/PP interface [polypeptide binding]; other site
251221005678	TPP binding site [chemical binding]; other site
251221005679	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
251221005680	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
251221005681	TPP-binding site [chemical binding]; other site
251221005682	dimer interface [polypeptide binding]; other site
251221005683	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
251221005684	FOG: CBS domain [General function prediction only]; Region: COG0517
251221005685	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
251221005686	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
251221005687	FOG: CBS domain [General function prediction only]; Region: COG0517
251221005688	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
251221005689	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221005690	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
251221005691	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221005692	dimer interface [polypeptide binding]; other site
251221005693	phosphorylation site [posttranslational modification]
251221005694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221005695	ATP binding site [chemical binding]; other site
251221005696	Mg2+ binding site [ion binding]; other site
251221005697	G-X-G motif; other site
251221005698	TrkA-C domain; Region: TrkA_C; pfam02080
251221005699	SnoaL-like domain; Region: SnoaL_2; pfam12680
251221005700	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
251221005701	MoaE interaction surface [polypeptide binding]; other site
251221005702	MoeB interaction surface [polypeptide binding]; other site
251221005703	thiocarboxylated glycine; other site
251221005704	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
251221005705	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
251221005706	homodimer interface [polypeptide binding]; other site
251221005707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221005708	catalytic residue [active]
251221005709	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221005710	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221005711	Coenzyme A binding pocket [chemical binding]; other site
251221005712	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
251221005713	Clp protease ATP binding subunit; Region: clpC; CHL00095
251221005714	Clp amino terminal domain; Region: Clp_N; pfam02861
251221005715	Clp amino terminal domain; Region: Clp_N; pfam02861
251221005716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221005717	Walker A motif; other site
251221005718	ATP binding site [chemical binding]; other site
251221005719	Walker B motif; other site
251221005720	arginine finger; other site
251221005721	UvrB/uvrC motif; Region: UVR; pfam02151
251221005722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221005723	Walker A motif; other site
251221005724	ATP binding site [chemical binding]; other site
251221005725	Walker B motif; other site
251221005726	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
251221005727	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
251221005728	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
251221005729	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
251221005730	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
251221005731	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
251221005732	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
251221005733	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
251221005734	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
251221005735	Clp amino terminal domain; Region: Clp_N; pfam02861
251221005736	Clp amino terminal domain; Region: Clp_N; pfam02861
251221005737	Putative restriction endonuclease; Region: Uma2; pfam05685
251221005738	putative active site [active]
251221005739	Uncharacterized conserved protein [Function unknown]; Region: COG2308
251221005740	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
251221005741	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
251221005742	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
251221005743	Walker A/P-loop; other site
251221005744	ATP binding site [chemical binding]; other site
251221005745	Q-loop/lid; other site
251221005746	ABC transporter signature motif; other site
251221005747	Walker B; other site
251221005748	D-loop; other site
251221005749	H-loop/switch region; other site
251221005750	TOBE-like domain; Region: TOBE_3; pfam12857
251221005751	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
251221005752	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
251221005753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221005754	dimer interface [polypeptide binding]; other site
251221005755	conserved gate region; other site
251221005756	putative PBP binding loops; other site
251221005757	ABC-ATPase subunit interface; other site
251221005758	sulfate transport protein; Provisional; Region: cysT; CHL00187
251221005759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221005760	dimer interface [polypeptide binding]; other site
251221005761	conserved gate region; other site
251221005762	putative PBP binding loops; other site
251221005763	ABC-ATPase subunit interface; other site
251221005764	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
251221005765	Predicted transcriptional regulator [Transcription]; Region: COG3905
251221005766	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
251221005767	Beta-propeller repeat; Region: SBBP; pfam06739
251221005768	Beta-propeller repeat; Region: SBBP; pfam06739
251221005769	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221005770	23S rRNA m2A2503 methyltransferase; Region: TIGR00048
251221005771	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221005772	FeS/SAM binding site; other site
251221005773	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
251221005774	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
251221005775	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
251221005776	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221005777	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
251221005778	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
251221005779	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221005780	DNA polymerase II large subunit; Provisional; Region: PRK14714
251221005781	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
251221005782	NMT1-like family; Region: NMT1_2; pfam13379
251221005783	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
251221005784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221005785	dimer interface [polypeptide binding]; other site
251221005786	conserved gate region; other site
251221005787	putative PBP binding loops; other site
251221005788	ABC-ATPase subunit interface; other site
251221005789	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
251221005790	active site clefts [active]
251221005791	zinc binding site [ion binding]; other site
251221005792	dimer interface [polypeptide binding]; other site
251221005793	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
251221005794	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
251221005795	Walker A/P-loop; other site
251221005796	ATP binding site [chemical binding]; other site
251221005797	Q-loop/lid; other site
251221005798	ABC transporter signature motif; other site
251221005799	Walker B; other site
251221005800	D-loop; other site
251221005801	H-loop/switch region; other site
251221005802	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
251221005803	NMT1-like family; Region: NMT1_2; pfam13379
251221005804	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
251221005805	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
251221005806	Walker A/P-loop; other site
251221005807	ATP binding site [chemical binding]; other site
251221005808	Q-loop/lid; other site
251221005809	ABC transporter signature motif; other site
251221005810	Walker B; other site
251221005811	D-loop; other site
251221005812	H-loop/switch region; other site
251221005813	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
251221005814	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
251221005815	Hexamer interface [polypeptide binding]; other site
251221005816	Hexagonal pore residue; other site
251221005817	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
251221005818	Hexamer interface [polypeptide binding]; other site
251221005819	Hexagonal pore residue; other site
251221005820	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221005821	putative trimer interface [polypeptide binding]; other site
251221005822	putative CoA binding site [chemical binding]; other site
251221005823	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
251221005824	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
251221005825	trimer interface [polypeptide binding]; other site
251221005826	active site
251221005827	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
251221005828	putative multimerization interface [polypeptide binding]; other site
251221005829	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
251221005830	putative multimerization interface [polypeptide binding]; other site
251221005831	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
251221005832	putative multimerization interface [polypeptide binding]; other site
251221005833	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
251221005834	putative multimerization interface [polypeptide binding]; other site
251221005835	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
251221005836	Hexamer/Pentamer interface [polypeptide binding]; other site
251221005837	central pore; other site
251221005838	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
251221005839	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
251221005840	Hexamer interface [polypeptide binding]; other site
251221005841	Hexagonal pore residue; other site
251221005842	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
251221005843	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
251221005844	Hexamer interface [polypeptide binding]; other site
251221005845	Hexagonal pore residue; other site
251221005846	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
251221005847	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
251221005848	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
251221005849	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
251221005850	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
251221005851	Phytase; Region: Phytase; cl17685
251221005852	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
251221005853	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221005854	FeS/SAM binding site; other site
251221005855	FtsH Extracellular; Region: FtsH_ext; pfam06480
251221005856	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
251221005857	active site
251221005858	ATP binding site [chemical binding]; other site
251221005859	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221005860	substrate binding site [chemical binding]; other site
251221005861	activation loop (A-loop); other site
251221005862	tryptophan-rich conserved hypothetical protein; Region: TIGR02450
251221005863	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
251221005864	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
251221005865	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
251221005866	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
251221005867	protein binding site [polypeptide binding]; other site
251221005868	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
251221005869	putative catalytic residue [active]
251221005870	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
251221005871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221005872	Walker A motif; other site
251221005873	ATP binding site [chemical binding]; other site
251221005874	Walker B motif; other site
251221005875	arginine finger; other site
251221005876	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
251221005877	Cupin domain; Region: Cupin_2; pfam07883
251221005878	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
251221005879	substrate binding site [chemical binding]; other site
251221005880	putative active site [active]
251221005881	redox center [active]
251221005882	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
251221005883	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
251221005884	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
251221005885	dimerization interface [polypeptide binding]; other site
251221005886	ATP binding site [chemical binding]; other site
251221005887	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
251221005888	dimerization interface [polypeptide binding]; other site
251221005889	ATP binding site [chemical binding]; other site
251221005890	amidophosphoribosyltransferase; Provisional; Region: PRK07349
251221005891	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
251221005892	active site
251221005893	tetramer interface [polypeptide binding]; other site
251221005894	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221005895	active site
251221005896	HD domain; Region: HD_4; pfam13328
251221005897	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
251221005898	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221005899	N-terminal plug; other site
251221005900	ligand-binding site [chemical binding]; other site
251221005901	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
251221005902	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005903	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005904	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005905	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005906	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221005907	enolase; Provisional; Region: eno; PRK00077
251221005908	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
251221005909	dimer interface [polypeptide binding]; other site
251221005910	metal binding site [ion binding]; metal-binding site
251221005911	substrate binding pocket [chemical binding]; other site
251221005912	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
251221005913	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
251221005914	active site
251221005915	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
251221005916	putative active site [active]
251221005917	putative metal binding site [ion binding]; other site
251221005918	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
251221005919	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
251221005920	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221005921	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
251221005922	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221005923	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221005924	active site
251221005925	ATP binding site [chemical binding]; other site
251221005926	substrate binding site [chemical binding]; other site
251221005927	activation loop (A-loop); other site
251221005928	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
251221005929	Integrase core domain; Region: rve_3; cl15866
251221005930	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221005931	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
251221005932	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
251221005933	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221005934	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
251221005935	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
251221005936	CoA-binding site [chemical binding]; other site
251221005937	ATP-binding [chemical binding]; other site
251221005938	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
251221005939	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
251221005940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221005941	S-adenosylmethionine binding site [chemical binding]; other site
251221005942	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
251221005943	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221005944	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221005945	Cupin domain; Region: Cupin_2; cl17218
251221005946	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
251221005947	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
251221005948	ligand binding site [chemical binding]; other site
251221005949	NAD binding site [chemical binding]; other site
251221005950	dimerization interface [polypeptide binding]; other site
251221005951	catalytic site [active]
251221005952	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
251221005953	putative L-serine binding site [chemical binding]; other site
251221005954	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
251221005955	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
251221005956	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
251221005957	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
251221005958	peptide binding site [polypeptide binding]; other site
251221005959	Uncharacterized conserved protein [Function unknown]; Region: COG5464
251221005960	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
251221005961	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221005962	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
251221005963	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
251221005964	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
251221005965	catalytic residues [active]
251221005966	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
251221005967	Acyl transferase domain; Region: Acyl_transf_1; cl08282
251221005968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
251221005969	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
251221005970	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
251221005971	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
251221005972	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
251221005973	Malic enzyme, N-terminal domain; Region: malic; pfam00390
251221005974	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
251221005975	putative NAD(P) binding site [chemical binding]; other site
251221005976	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
251221005977	Fasciclin domain; Region: Fasciclin; pfam02469
251221005978	TIGR02588 family protein; Region: TIGR02588
251221005979	Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622
251221005980	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
251221005981	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
251221005982	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221005983	NAD(P) binding site [chemical binding]; other site
251221005984	active site
251221005985	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
251221005986	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
251221005987	dimer interface [polypeptide binding]; other site
251221005988	decamer (pentamer of dimers) interface [polypeptide binding]; other site
251221005989	catalytic triad [active]
251221005990	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
251221005991	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
251221005992	homodimer interface [polypeptide binding]; other site
251221005993	active site
251221005994	heterodimer interface [polypeptide binding]; other site
251221005995	catalytic residue [active]
251221005996	metal binding site [ion binding]; metal-binding site
251221005997	RbcX protein; Region: RcbX; pfam02341
251221005998	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
251221005999	multimerization interface [polypeptide binding]; other site
251221006000	Mut7-C RNAse domain; Region: Mut7-C; cl19501
251221006001	Protein of unknown function (DUF433); Region: DUF433; pfam04255
251221006002	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
251221006003	Subunit I/III interface [polypeptide binding]; other site
251221006004	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
251221006005	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
251221006006	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
251221006007	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
251221006008	Uncharacterized subfamily with similarity to Heme-copper oxidase subunit II cupredoxin domain; Region: CuRO_HCO_II_like_5; cd13919
251221006009	CuA binuclear center [ion binding]; other site
251221006010	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
251221006011	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
251221006012	putative active site [active]
251221006013	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221006014	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
251221006015	Walker A/P-loop; other site
251221006016	ATP binding site [chemical binding]; other site
251221006017	Q-loop/lid; other site
251221006018	ABC transporter signature motif; other site
251221006019	Walker B; other site
251221006020	D-loop; other site
251221006021	H-loop/switch region; other site
251221006022	ABC-2 type transporter; Region: ABC2_membrane; cl17235
251221006023	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
251221006024	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
251221006025	E-class dimer interface [polypeptide binding]; other site
251221006026	P-class dimer interface [polypeptide binding]; other site
251221006027	active site
251221006028	Cu2+ binding site [ion binding]; other site
251221006029	Zn2+ binding site [ion binding]; other site
251221006030	Kelch motif; Region: Kelch_6; pfam13964
251221006031	Kelch domain; Region: Kelch; smart00612
251221006032	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
251221006033	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
251221006034	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
251221006035	trimer interface [polypeptide binding]; other site
251221006036	putative metal binding site [ion binding]; other site
251221006037	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
251221006038	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
251221006039	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
251221006040	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
251221006041	molybdopterin cofactor binding site; other site
251221006042	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
251221006043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221006044	non-specific DNA binding site [nucleotide binding]; other site
251221006045	salt bridge; other site
251221006046	sequence-specific DNA binding site [nucleotide binding]; other site
251221006047	Double zinc ribbon; Region: DZR; pfam12773
251221006048	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
251221006049	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
251221006050	trimer interface [polypeptide binding]; other site
251221006051	active site
251221006052	substrate binding site [chemical binding]; other site
251221006053	CoA binding site [chemical binding]; other site
251221006054	GAF domain; Region: GAF; pfam01590
251221006055	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
251221006056	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
251221006057	NAD binding site [chemical binding]; other site
251221006058	putative substrate binding site 2 [chemical binding]; other site
251221006059	putative substrate binding site 1 [chemical binding]; other site
251221006060	active site
251221006061	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
251221006062	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
251221006063	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
251221006064	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
251221006065	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221006066	PAS domain; Region: PAS_9; pfam13426
251221006067	putative active site [active]
251221006068	heme pocket [chemical binding]; other site
251221006069	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
251221006070	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221006071	putative trimer interface [polypeptide binding]; other site
251221006072	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
251221006073	putative CoA binding site [chemical binding]; other site
251221006074	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
251221006075	trimer interface [polypeptide binding]; other site
251221006076	active site
251221006077	substrate binding site [chemical binding]; other site
251221006078	CoA binding site [chemical binding]; other site
251221006079	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
251221006080	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221006081	putative trimer interface [polypeptide binding]; other site
251221006082	putative CoA binding site [chemical binding]; other site
251221006083	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
251221006084	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
251221006085	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
251221006086	substrate binding site; other site
251221006087	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
251221006088	Homeodomain-like domain; Region: HTH_23; pfam13384
251221006089	Homeodomain-like domain; Region: HTH_32; pfam13565
251221006090	Bacterial sugar transferase; Region: Bac_transf; pfam02397
251221006091	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
251221006092	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221006093	active site
251221006094	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221006095	active site
251221006096	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
251221006097	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
251221006098	active site
251221006099	Sulfotransferase domain; Region: Sulfotransfer_1; cl19239
251221006100	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221006101	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
251221006102	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
251221006103	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221006104	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221006105	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221006106	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
251221006107	Walker A/P-loop; other site
251221006108	ATP binding site [chemical binding]; other site
251221006109	Q-loop/lid; other site
251221006110	ABC transporter signature motif; other site
251221006111	Walker B; other site
251221006112	D-loop; other site
251221006113	H-loop/switch region; other site
251221006114	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
251221006115	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221006116	putative ADP-binding pocket [chemical binding]; other site
251221006117	active site
251221006118	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
251221006119	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
251221006120	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
251221006121	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
251221006122	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
251221006123	active site
251221006124	Substrate binding site; other site
251221006125	Mg++ binding site; other site
251221006126	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221006127	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
251221006128	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
251221006129	SLBB domain; Region: SLBB; pfam10531
251221006130	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
251221006131	Chain length determinant protein; Region: Wzz; pfam02706
251221006132	Actin cytoskeleton-regulatory complex protein END3; Region: End3; pfam12761
251221006133	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
251221006134	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
251221006135	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221006136	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
251221006137	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
251221006138	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
251221006139	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
251221006140	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
251221006141	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
251221006142	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
251221006143	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
251221006144	extended (e) SDRs; Region: SDR_e; cd08946
251221006145	NAD(P) binding site [chemical binding]; other site
251221006146	active site
251221006147	substrate binding site [chemical binding]; other site
251221006148	Predicted dehydrogenase [General function prediction only]; Region: COG0579
251221006149	hydroxyglutarate oxidase; Provisional; Region: PRK11728
251221006150	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
251221006151	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
251221006152	substrate binding site; other site
251221006153	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221006154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221006155	active site
251221006156	phosphorylation site [posttranslational modification]
251221006157	intermolecular recognition site; other site
251221006158	dimerization interface [polypeptide binding]; other site
251221006159	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221006160	DNA binding residues [nucleotide binding]
251221006161	dimerization interface [polypeptide binding]; other site
251221006162	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
251221006163	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221006164	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221006165	ligand binding site [chemical binding]; other site
251221006166	flexible hinge region; other site
251221006167	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221006168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221006169	ATP binding site [chemical binding]; other site
251221006170	Mg2+ binding site [ion binding]; other site
251221006171	G-X-G motif; other site
251221006172	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
251221006173	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
251221006174	glutaminase active site [active]
251221006175	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
251221006176	dimer interface [polypeptide binding]; other site
251221006177	active site
251221006178	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
251221006179	dimer interface [polypeptide binding]; other site
251221006180	active site
251221006181	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
251221006182	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
251221006183	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221006184	Coenzyme A binding pocket [chemical binding]; other site
251221006185	histidine decarboxylase; Provisional; Region: PRK02769
251221006186	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221006187	catalytic residue [active]
251221006188	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
251221006189	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
251221006190	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221006191	catalytic residue [active]
251221006192	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
251221006193	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
251221006194	inhibitor-cofactor binding pocket; inhibition site
251221006195	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221006196	catalytic residue [active]
251221006197	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
251221006198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006199	TPR motif; other site
251221006200	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221006201	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006202	binding surface
251221006203	TPR motif; other site
251221006204	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221006205	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221006206	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221006207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006208	binding surface
251221006209	TPR motif; other site
251221006210	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221006211	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221006212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006213	TPR motif; other site
251221006214	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221006215	binding surface
251221006216	CHAT domain; Region: CHAT; pfam12770
251221006217	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
251221006218	active site
251221006219	catalytic residues [active]
251221006220	metal binding site [ion binding]; metal-binding site
251221006221	rod shape-determining protein MreB; Provisional; Region: PRK13930
251221006222	MreB and similar proteins; Region: MreB_like; cd10225
251221006223	nucleotide binding site [chemical binding]; other site
251221006224	Mg binding site [ion binding]; other site
251221006225	putative protofilament interaction site [polypeptide binding]; other site
251221006226	RodZ interaction site [polypeptide binding]; other site
251221006227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
251221006228	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
251221006229	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
251221006230	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
251221006231	G-X-X-G motif; other site
251221006232	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
251221006233	RxxxH motif; other site
251221006234	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
251221006235	HEAT repeats; Region: HEAT_2; pfam13646
251221006236	HEAT repeats; Region: HEAT_2; pfam13646
251221006237	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
251221006238	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
251221006239	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
251221006240	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
251221006241	Uncharacterized conserved protein [Function unknown]; Region: COG0062
251221006242	putative carbohydrate kinase; Provisional; Region: PRK10565
251221006243	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
251221006244	putative substrate binding site [chemical binding]; other site
251221006245	putative ATP binding site [chemical binding]; other site
251221006246	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
251221006247	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
251221006248	putative acyl-acceptor binding pocket; other site
251221006249	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221006250	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
251221006251	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
251221006252	Caspase domain; Region: Peptidase_C14; pfam00656
251221006253	AAA ATPase domain; Region: AAA_16; pfam13191
251221006254	Fez1; Region: Fez1; pfam06818
251221006255	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221006256	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221006257	structural tetrad; other site
251221006258	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221006259	structural tetrad; other site
251221006260	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221006261	structural tetrad; other site
251221006262	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221006263	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
251221006264	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221006265	FeS/SAM binding site; other site
251221006266	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
251221006267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
251221006268	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221006269	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221006270	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
251221006271	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
251221006272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221006273	Walker A/P-loop; other site
251221006274	ATP binding site [chemical binding]; other site
251221006275	Q-loop/lid; other site
251221006276	ABC transporter signature motif; other site
251221006277	Walker B; other site
251221006278	D-loop; other site
251221006279	H-loop/switch region; other site
251221006280	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
251221006281	Transposase [DNA replication, recombination, and repair]; Region: COG5421
251221006282	DNA translocase FtsK; Provisional; Region: PRK10263
251221006283	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
251221006284	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
251221006285	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
251221006286	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
251221006287	Protein of unknown function (DUF3080); Region: DUF3080; pfam11279
251221006288	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006289	TPR motif; other site
251221006290	TPR repeat; Region: TPR_11; pfam13414
251221006291	binding surface
251221006292	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
251221006293	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
251221006294	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
251221006295	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221006296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221006297	active site
251221006298	phosphorylation site [posttranslational modification]
251221006299	intermolecular recognition site; other site
251221006300	dimerization interface [polypeptide binding]; other site
251221006301	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
251221006302	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221006303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221006304	dimer interface [polypeptide binding]; other site
251221006305	phosphorylation site [posttranslational modification]
251221006306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221006307	ATP binding site [chemical binding]; other site
251221006308	Mg2+ binding site [ion binding]; other site
251221006309	G-X-G motif; other site
251221006310	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
251221006311	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
251221006312	putative NAD(P) binding site [chemical binding]; other site
251221006313	dimer interface [polypeptide binding]; other site
251221006314	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
251221006315	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
251221006316	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221006317	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
251221006318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221006319	putative substrate translocation pore; other site
251221006320	CsbD-like; Region: CsbD; pfam05532
251221006321	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221006322	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
251221006323	Walker A/P-loop; other site
251221006324	ATP binding site [chemical binding]; other site
251221006325	Q-loop/lid; other site
251221006326	ABC transporter signature motif; other site
251221006327	Walker B; other site
251221006328	D-loop; other site
251221006329	H-loop/switch region; other site
251221006330	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
251221006331	SNF2 Helicase protein; Region: DUF3670; pfam12419
251221006332	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
251221006333	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221006334	ATP binding site [chemical binding]; other site
251221006335	putative Mg++ binding site [ion binding]; other site
251221006336	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221006337	nucleotide binding region [chemical binding]; other site
251221006338	ATP-binding site [chemical binding]; other site
251221006339	SWIM zinc finger; Region: SWIM; cl19527
251221006340	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
251221006341	active site
251221006342	Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863
251221006343	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
251221006344	HrcA protein C terminal domain; Region: HrcA; pfam01628
251221006345	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221006346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221006347	active site
251221006348	phosphorylation site [posttranslational modification]
251221006349	intermolecular recognition site; other site
251221006350	dimerization interface [polypeptide binding]; other site
251221006351	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221006352	dimer interface [polypeptide binding]; other site
251221006353	phosphorylation site [posttranslational modification]
251221006354	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221006355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221006356	active site
251221006357	phosphorylation site [posttranslational modification]
251221006358	intermolecular recognition site; other site
251221006359	dimerization interface [polypeptide binding]; other site
251221006360	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221006361	DNA binding site [nucleotide binding]
251221006362	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
251221006363	Plastocyanin is a type I copper protein and functions in the electron transfer from PSII to PSI; Region: Plastocyanin; cd04219
251221006364	Type 1 (T1) Cu binding site [ion binding]; other site
251221006365	Berberine and berberine like; Region: BBE; pfam08031
251221006366	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
251221006367	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
251221006368	NADP binding site [chemical binding]; other site
251221006369	active site
251221006370	regulatory binding site [polypeptide binding]; other site
251221006371	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
251221006372	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
251221006373	Walker A/P-loop; other site
251221006374	ATP binding site [chemical binding]; other site
251221006375	Q-loop/lid; other site
251221006376	ABC transporter signature motif; other site
251221006377	Walker B; other site
251221006378	D-loop; other site
251221006379	H-loop/switch region; other site
251221006380	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
251221006381	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
251221006382	dimerization interface [polypeptide binding]; other site
251221006383	domain crossover interface; other site
251221006384	redox-dependent activation switch; other site
251221006385	Hemerythrin family; Region: Hemerythrin-like; cl15774
251221006386	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
251221006387	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
251221006388	RPB12 interaction site [polypeptide binding]; other site
251221006389	RPB1 interaction site [polypeptide binding]; other site
251221006390	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
251221006391	RPB10 interaction site [polypeptide binding]; other site
251221006392	RPB11 interaction site [polypeptide binding]; other site
251221006393	RPB3 interaction site [polypeptide binding]; other site
251221006394	Uncharacterized conserved protein [Function unknown]; Region: COG4715
251221006395	SWIM zinc finger; Region: SWIM; pfam04434
251221006396	PemK-like protein; Region: PemK; pfam02452
251221006397	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421
251221006398	active site
251221006399	2-isopropylmalate synthase; Validated; Region: PRK00915
251221006400	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
251221006401	active site
251221006402	catalytic residues [active]
251221006403	metal binding site [ion binding]; metal-binding site
251221006404	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
251221006405	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
251221006406	HEPN domain; Region: HEPN; pfam05168
251221006407	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
251221006408	active site
251221006409	NTP binding site [chemical binding]; other site
251221006410	metal binding triad [ion binding]; metal-binding site
251221006411	antibiotic binding site [chemical binding]; other site
251221006412	carboxylate-amine ligase; Provisional; Region: PRK13517
251221006413	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
251221006414	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
251221006415	dimerization interface [polypeptide binding]; other site
251221006416	FAD binding pocket [chemical binding]; other site
251221006417	FAD binding motif [chemical binding]; other site
251221006418	catalytic residues [active]
251221006419	NAD binding pocket [chemical binding]; other site
251221006420	phosphate binding motif [ion binding]; other site
251221006421	beta-alpha-beta structure motif; other site
251221006422	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
251221006423	active site
251221006424	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
251221006425	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
251221006426	TPP-binding site [chemical binding]; other site
251221006427	dimer interface [polypeptide binding]; other site
251221006428	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
251221006429	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
251221006430	PYR/PP interface [polypeptide binding]; other site
251221006431	dimer interface [polypeptide binding]; other site
251221006432	TPP binding site [chemical binding]; other site
251221006433	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
251221006434	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
251221006435	active site
251221006436	substrate binding site [chemical binding]; other site
251221006437	Mg2+ binding site [ion binding]; other site
251221006438	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
251221006439	PIN domain; Region: PIN_3; pfam13470
251221006440	RelB antitoxin; Region: RelB; cl01171
251221006441	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221006442	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221006443	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221006444	WG containing repeat; Region: WG_beta_rep; pfam14903
251221006445	WG containing repeat; Region: WG_beta_rep; pfam14903
251221006446	WG containing repeat; Region: WG_beta_rep; pfam14903
251221006447	WG containing repeat; Region: WG_beta_rep; pfam14903
251221006448	WG containing repeat; Region: WG_beta_rep; pfam14903
251221006449	Helix-turn-helix domain; Region: HTH_17; cl17695
251221006450	Helix-turn-helix domain; Region: HTH_36; pfam13730
251221006451	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
251221006452	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
251221006453	dinuclear metal binding motif [ion binding]; other site
251221006454	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
251221006455	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
251221006456	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
251221006457	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
251221006458	acyl carrier protein; Provisional; Region: acpP; PRK00982
251221006459	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
251221006460	substrate binding site [chemical binding]; other site
251221006461	hinge regions; other site
251221006462	ADP binding site [chemical binding]; other site
251221006463	catalytic site [active]
251221006464	B12 binding domain; Region: B12-binding; pfam02310
251221006465	B12 binding site [chemical binding]; other site
251221006466	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
251221006467	Radical SAM superfamily; Region: Radical_SAM; pfam04055
251221006468	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
251221006469	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
251221006470	substrate binding site [chemical binding]; other site
251221006471	dimer interface [polypeptide binding]; other site
251221006472	ATP binding site [chemical binding]; other site
251221006473	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
251221006474	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
251221006475	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
251221006476	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
251221006477	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
251221006478	FAD binding domain; Region: FAD_binding_4; pfam01565
251221006479	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
251221006480	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
251221006481	Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; smart00944
251221006482	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
251221006483	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221006484	catalytic residue [active]
251221006485	thymidylate synthase, flavin-dependent; Region: thyX; TIGR02170
251221006486	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
251221006487	pheophytin binding site; other site
251221006488	chlorophyll binding site; other site
251221006489	quinone binding site; other site
251221006490	Fe binding site [ion binding]; other site
251221006491	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
251221006492	pheophytin binding site; other site
251221006493	chlorophyll binding site; other site
251221006494	quinone binding site; other site
251221006495	Fe binding site [ion binding]; other site
251221006496	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
251221006497	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
251221006498	DEAD-like helicases superfamily; Region: DEXDc; smart00487
251221006499	ATP binding site [chemical binding]; other site
251221006500	Mg++ binding site [ion binding]; other site
251221006501	motif III; other site
251221006502	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221006503	nucleotide binding region [chemical binding]; other site
251221006504	ATP-binding site [chemical binding]; other site
251221006505	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
251221006506	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
251221006507	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221006508	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221006509	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221006510	Walker A/P-loop; other site
251221006511	ATP binding site [chemical binding]; other site
251221006512	Q-loop/lid; other site
251221006513	ABC transporter signature motif; other site
251221006514	Walker B; other site
251221006515	D-loop; other site
251221006516	H-loop/switch region; other site
251221006517	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
251221006518	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221006519	FUN14 family; Region: FUN14; pfam04930
251221006520	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
251221006521	hydrolase, alpha/beta fold family protein; Region: PLN02824
251221006522	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221006523	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
251221006524	cytochrome c-550; Provisional; Region: psbV; PRK13621
251221006525	photosystem II cytochrome PsbV2; Region: PS_II_psbV2; TIGR03046
251221006526	Cytochrome c-550 domain; Region: Cytochrom_C550; pfam14495
251221006527	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
251221006528	putative nucleotide binding site [chemical binding]; other site
251221006529	uridine monophosphate binding site [chemical binding]; other site
251221006530	homohexameric interface [polypeptide binding]; other site
251221006531	Plastocyanin is a type I copper protein and functions in the electron transfer from PSII to PSI; Region: Plastocyanin; cd04219
251221006532	Type 1 (T1) Cu binding site [ion binding]; other site
251221006533	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
251221006534	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
251221006535	GatB domain; Region: GatB_Yqey; smart00845
251221006536	Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962
251221006537	Conserved TM helix; Region: TM_helix; pfam05552
251221006538	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221006539	putative active site [active]
251221006540	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
251221006541	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221006542	active site
251221006543	motif I; other site
251221006544	motif II; other site
251221006545	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
251221006546	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221006547	putative active site [active]
251221006548	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
251221006549	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
251221006550	motif 1; other site
251221006551	active site
251221006552	motif 2; other site
251221006553	motif 3; other site
251221006554	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
251221006555	DHHA1 domain; Region: DHHA1; pfam02272
251221006556	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
251221006557	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
251221006558	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
251221006559	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
251221006560	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
251221006561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221006562	Coenzyme A binding pocket [chemical binding]; other site
251221006563	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
251221006564	Mg++ binding site [ion binding]; other site
251221006565	putative catalytic motif [active]
251221006566	substrate binding site [chemical binding]; other site
251221006567	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
251221006568	dimerization interface [polypeptide binding]; other site
251221006569	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
251221006570	ligand binding site [chemical binding]; other site
251221006571	human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs; Region: DHRS1-like_SDR_c; cd09763
251221006572	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
251221006573	NAD(P) binding site [chemical binding]; other site
251221006574	putative dimer interface [polypeptide binding]; other site
251221006575	active site
251221006576	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
251221006577	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
251221006578	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
251221006579	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223
251221006580	Predicted transcriptional regulator [Transcription]; Region: COG3905
251221006581	threonine synthase; Validated; Region: PRK06260
251221006582	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
251221006583	homodimer interface [polypeptide binding]; other site
251221006584	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221006585	catalytic residue [active]
251221006586	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
251221006587	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
251221006588	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
251221006589	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
251221006590	active site
251221006591	Uncharacterized conserved protein [Function unknown]; Region: COG2128
251221006592	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
251221006593	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
251221006594	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
251221006595	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
251221006596	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
251221006597	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
251221006598	P-loop; other site
251221006599	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
251221006600	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
251221006601	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
251221006602	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
251221006603	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
251221006604	catalytic triad [active]
251221006605	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
251221006606	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
251221006607	catalytic triad [active]
251221006608	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
251221006609	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
251221006610	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
251221006611	active site
251221006612	HIGH motif; other site
251221006613	KMSKS motif; other site
251221006614	NADH dehydrogenase subunit B; Validated; Region: PRK06411
251221006615	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
251221006616	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
251221006617	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
251221006618	oligomeric interface; other site
251221006619	putative active site [active]
251221006620	homodimer interface [polypeptide binding]; other site
251221006621	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
251221006622	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
251221006623	Uncharacterized conserved protein [Function unknown]; Region: COG1565
251221006624	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
251221006625	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
251221006626	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221006627	Coenzyme A binding pocket [chemical binding]; other site
251221006628	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
251221006629	Stage II sporulation protein; Region: SpoIID; pfam08486
251221006630	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
251221006631	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
251221006632	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
251221006633	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
251221006634	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221006635	Ligand Binding Site [chemical binding]; other site
251221006636	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221006637	Ligand Binding Site [chemical binding]; other site
251221006638	Predicted integral membrane protein [Function unknown]; Region: COG5616
251221006639	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
251221006640	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006641	TPR motif; other site
251221006642	binding surface
251221006643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006644	binding surface
251221006645	TPR motif; other site
251221006646	TPR repeat; Region: TPR_11; pfam13414
251221006647	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006648	TPR motif; other site
251221006649	binding surface
251221006650	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
251221006651	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
251221006652	dimer interface [polypeptide binding]; other site
251221006653	motif 1; other site
251221006654	active site
251221006655	motif 2; other site
251221006656	motif 3; other site
251221006657	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221006658	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
251221006659	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
251221006660	Part of AAA domain; Region: AAA_19; pfam13245
251221006661	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
251221006662	Protein of unknown function (DUF433); Region: DUF433; pfam04255
251221006663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
251221006664	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
251221006665	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
251221006666	HSP70 interaction site [polypeptide binding]; other site
251221006667	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
251221006668	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
251221006669	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
251221006670	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
251221006671	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
251221006672	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
251221006673	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
251221006674	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
251221006675	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
251221006676	recombination protein F; Reviewed; Region: recF; PRK00064
251221006677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221006678	Walker A/P-loop; other site
251221006679	ATP binding site [chemical binding]; other site
251221006680	Q-loop/lid; other site
251221006681	ABC transporter signature motif; other site
251221006682	Walker B; other site
251221006683	D-loop; other site
251221006684	H-loop/switch region; other site
251221006685	DNA repair protein RadA; Provisional; Region: PRK11823
251221006686	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
251221006687	Walker A motif/ATP binding site; other site
251221006688	ATP binding site [chemical binding]; other site
251221006689	Walker B motif; other site
251221006690	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
251221006691	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
251221006692	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
251221006693	Fe-S cluster binding site [ion binding]; other site
251221006694	active site
251221006695	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
251221006696	putative substrate binding pocket [chemical binding]; other site
251221006697	AC domain interface; other site
251221006698	catalytic triad [active]
251221006699	AB domain interface; other site
251221006700	interchain disulfide; other site
251221006701	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221006702	putative active site [active]
251221006703	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
251221006704	active site
251221006705	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
251221006706	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
251221006707	Uncharacterized conserved protein [Function unknown]; Region: COG5464
251221006708	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
251221006709	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
251221006710	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
251221006711	SWIM zinc finger; Region: SWIM; cl19527
251221006712	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
251221006713	SNF2 Helicase protein; Region: DUF3670; pfam12419
251221006714	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221006715	ATP binding site [chemical binding]; other site
251221006716	putative Mg++ binding site [ion binding]; other site
251221006717	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221006718	nucleotide binding region [chemical binding]; other site
251221006719	ATP-binding site [chemical binding]; other site
251221006720	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221006721	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221006722	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221006723	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221006724	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221006725	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
251221006726	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
251221006727	active site
251221006728	TDP-binding site; other site
251221006729	acceptor substrate-binding pocket; other site
251221006730	homodimer interface [polypeptide binding]; other site
251221006731	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221006732	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221006733	S-adenosylmethionine binding site [chemical binding]; other site
251221006734	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
251221006735	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
251221006736	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
251221006737	PemK-like protein; Region: PemK; pfam02452
251221006738	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
251221006739	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221006740	FtsX-like permease family; Region: FtsX; pfam02687
251221006741	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
251221006742	FtsX-like permease family; Region: FtsX; pfam02687
251221006743	Transcriptional regulator PadR-like family; Region: PadR; cl17335
251221006744	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
251221006745	Protein of unknown function DUF104; Region: DUF104; cl11530
251221006746	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
251221006747	putative active site [active]
251221006748	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
251221006749	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
251221006750	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
251221006751	Type IV pilus assembly protein PilM; Region: PilM_2; pfam11104
251221006752	Fimbrial assembly protein (PilN); Region: PilN; cl19830
251221006753	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
251221006754	Secretin and TonB N terminus short domain; Region: STN; pfam07660
251221006755	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
251221006756	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
251221006757	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221006758	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221006759	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
251221006760	competence damage-inducible protein A; Provisional; Region: PRK00549
251221006761	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
251221006762	putative MPT binding site; other site
251221006763	Competence-damaged protein; Region: CinA; pfam02464
251221006764	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
251221006765	trimer interface [polypeptide binding]; other site
251221006766	active site
251221006767	dimer interface [polypeptide binding]; other site
251221006768	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
251221006769	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
251221006770	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
251221006771	putative active site [active]
251221006772	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
251221006773	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
251221006774	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
251221006775	YCII-related domain; Region: YCII; cl00999
251221006776	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
251221006777	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221006778	NAD(P) binding site [chemical binding]; other site
251221006779	active site
251221006780	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
251221006781	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
251221006782	active site
251221006783	DNA binding site [nucleotide binding]
251221006784	Int/Topo IB signature motif; other site
251221006785	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
251221006786	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
251221006787	trmE is a tRNA modification GTPase; Region: trmE; cd04164
251221006788	G1 box; other site
251221006789	GTP/Mg2+ binding site [chemical binding]; other site
251221006790	Switch I region; other site
251221006791	G2 box; other site
251221006792	Switch II region; other site
251221006793	G3 box; other site
251221006794	G4 box; other site
251221006795	G5 box; other site
251221006796	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
251221006797	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221006798	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
251221006799	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221006800	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
251221006801	Outer membrane efflux protein; Region: OEP; pfam02321
251221006802	Outer membrane efflux protein; Region: OEP; pfam02321
251221006803	BDLF3; Provisional; Region: PHA03255
251221006804	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
251221006805	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
251221006806	Protein of unknown function, DUF608; Region: DUF608; pfam04685
251221006807	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
251221006808	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
251221006809	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
251221006810	P-loop; other site
251221006811	Magnesium ion binding site [ion binding]; other site
251221006812	Iguana/Dzip1-like DAZ-interacting protein N-terminal; Region: Dzip-like_N; pfam13815
251221006813	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
251221006814	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
251221006815	putative ADP-binding pocket [chemical binding]; other site
251221006816	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
251221006817	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221006818	active site
251221006819	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
251221006820	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
251221006821	homodimer interface [polypeptide binding]; other site
251221006822	active site
251221006823	TDP-binding site; other site
251221006824	acceptor substrate-binding pocket; other site
251221006825	CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain; Region: Cas3_I-D; cd09710
251221006826	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
251221006827	Family of unknown function (DUF566); Region: DUF566; pfam04484
251221006828	WYL domain; Region: WYL; pfam13280
251221006829	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221006830	putative active site [active]
251221006831	PemK-like protein; Region: PemK; cl00995
251221006832	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
251221006833	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
251221006834	putative active site [active]
251221006835	Zn binding site [ion binding]; other site
251221006836	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
251221006837	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
251221006838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221006839	homodimer interface [polypeptide binding]; other site
251221006840	catalytic residue [active]
251221006841	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
251221006842	folate binding site [chemical binding]; other site
251221006843	NADP+ binding site [chemical binding]; other site
251221006844	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
251221006845	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
251221006846	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
251221006847	tetramer interface [polypeptide binding]; other site
251221006848	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221006849	catalytic residue [active]
251221006850	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
251221006851	active site
251221006852	dimerization interface [polypeptide binding]; other site
251221006853	putative lipid kinase; Reviewed; Region: PRK00861
251221006854	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
251221006855	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
251221006856	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
251221006857	Catalytic site [active]
251221006858	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
251221006859	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
251221006860	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
251221006861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221006862	Walker A motif; other site
251221006863	ATP binding site [chemical binding]; other site
251221006864	Walker B motif; other site
251221006865	arginine finger; other site
251221006866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221006867	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
251221006868	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221006869	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
251221006870	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
251221006871	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
251221006872	putative NAD(P) binding site [chemical binding]; other site
251221006873	active site
251221006874	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
251221006875	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
251221006876	dimer interface [polypeptide binding]; other site
251221006877	ssDNA binding site [nucleotide binding]; other site
251221006878	tetramer (dimer of dimers) interface [polypeptide binding]; other site
251221006879	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
251221006880	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
251221006881	dimer interface [polypeptide binding]; other site
251221006882	ssDNA binding site [nucleotide binding]; other site
251221006883	tetramer (dimer of dimers) interface [polypeptide binding]; other site
251221006884	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
251221006885	active site
251221006886	DNA binding site [nucleotide binding]
251221006887	Uncharacterized conserved protein [Function unknown]; Region: COG2912
251221006888	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
251221006889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221006890	binding surface
251221006891	TPR motif; other site
251221006892	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
251221006893	MMPL family; Region: MMPL; cl14618
251221006894	MMPL family; Region: MMPL; cl14618
251221006895	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221006896	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221006897	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221006898	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221006899	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
251221006900	putative Zn2+ binding site [ion binding]; other site
251221006901	putative DNA binding site [nucleotide binding]; other site
251221006902	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
251221006903	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
251221006904	Uncharacterized conserved protein [Function unknown]; Region: COG2135
251221006905	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
251221006906	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
251221006907	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
251221006908	hypothetical protein; Validated; Region: PRK07581
251221006909	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
251221006910	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
251221006911	putative di-iron ligands [ion binding]; other site
251221006912	Cadmium resistance transporter; Region: Cad; cl19409
251221006913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221006914	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221006915	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
251221006916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221006917	ATP binding site [chemical binding]; other site
251221006918	Mg2+ binding site [ion binding]; other site
251221006919	G-X-G motif; other site
251221006920	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
251221006921	anchoring element; other site
251221006922	dimer interface [polypeptide binding]; other site
251221006923	ATP binding site [chemical binding]; other site
251221006924	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
251221006925	active site
251221006926	putative metal-binding site [ion binding]; other site
251221006927	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
251221006928	hypothetical protein; Validated; Region: PRK00110
251221006929	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
251221006930	DEAD-like helicases superfamily; Region: DEXDc; smart00487
251221006931	ATP binding site [chemical binding]; other site
251221006932	Mg++ binding site [ion binding]; other site
251221006933	motif III; other site
251221006934	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221006935	nucleotide binding region [chemical binding]; other site
251221006936	ATP-binding site [chemical binding]; other site
251221006937	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
251221006938	active site
251221006939	metal binding site [ion binding]; metal-binding site
251221006940	Domain of unknown function (DUF333); Region: DUF333; cl19829
251221006941	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
251221006942	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
251221006943	active site
251221006944	dimer interface [polypeptide binding]; other site
251221006945	metal binding site [ion binding]; metal-binding site
251221006946	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
251221006947	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
251221006948	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
251221006949	trimer interface [polypeptide binding]; other site
251221006950	active site
251221006951	substrate binding site [chemical binding]; other site
251221006952	CoA binding site [chemical binding]; other site
251221006953	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221006954	methionine sulfoxide reductase A; Provisional; Region: PRK00058
251221006955	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
251221006956	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
251221006957	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
251221006958	dimer interface [polypeptide binding]; other site
251221006959	active site
251221006960	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
251221006961	prolyl-tRNA synthetase; Provisional; Region: PRK09194
251221006962	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
251221006963	dimer interface [polypeptide binding]; other site
251221006964	motif 1; other site
251221006965	active site
251221006966	motif 2; other site
251221006967	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
251221006968	putative deacylase active site [active]
251221006969	motif 3; other site
251221006970	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
251221006971	anticodon binding site; other site
251221006972	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
251221006973	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
251221006974	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
251221006975	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
251221006976	active site
251221006977	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
251221006978	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
251221006979	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
251221006980	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
251221006981	Pirin-related protein [General function prediction only]; Region: COG1741
251221006982	Pirin; Region: Pirin; pfam02678
251221006983	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
251221006984	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
251221006985	intersubunit interface [polypeptide binding]; other site
251221006986	active site
251221006987	zinc binding site [ion binding]; other site
251221006988	Na+ binding site [ion binding]; other site
251221006989	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
251221006990	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221006991	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221006992	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221006993	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221006994	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221006995	NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008
251221006996	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221006997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221006998	H+ Antiporter protein; Region: 2A0121; TIGR00900
251221006999	putative substrate translocation pore; other site
251221007000	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
251221007001	conserved hypothetical protein; Region: TIGR03492
251221007002	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
251221007003	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
251221007004	metal binding site [ion binding]; metal-binding site
251221007005	dimer interface [polypeptide binding]; other site
251221007006	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
251221007007	malate dehydrogenase; Reviewed; Region: PRK06223
251221007008	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
251221007009	NAD(P) binding site [chemical binding]; other site
251221007010	dimer interface [polypeptide binding]; other site
251221007011	tetramer (dimer of dimers) interface [polypeptide binding]; other site
251221007012	substrate binding site [chemical binding]; other site
251221007013	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
251221007014	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
251221007015	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
251221007016	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
251221007017	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
251221007018	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
251221007019	active site
251221007020	SAM binding site [chemical binding]; other site
251221007021	homodimer interface [polypeptide binding]; other site
251221007022	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
251221007023	active site triad [active]
251221007024	AIPR protein; Region: AIPR; pfam10592
251221007025	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
251221007026	enoyl-CoA hydratase; Provisional; Region: PRK06688
251221007027	substrate binding site [chemical binding]; other site
251221007028	oxyanion hole (OAH) forming residues; other site
251221007029	trimer interface [polypeptide binding]; other site
251221007030	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221007031	NAD(P) binding site [chemical binding]; other site
251221007032	active site
251221007033	Transcriptional regulator [Transcription]; Region: LysR; COG0583
251221007034	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221007035	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
251221007036	putative effector binding pocket; other site
251221007037	dimerization interface [polypeptide binding]; other site
251221007038	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
251221007039	HEAT repeats; Region: HEAT_2; pfam13646
251221007040	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
251221007041	active site
251221007042	ribulose/triose binding site [chemical binding]; other site
251221007043	phosphate binding site [ion binding]; other site
251221007044	substrate (anthranilate) binding pocket [chemical binding]; other site
251221007045	product (indole) binding pocket [chemical binding]; other site
251221007046	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
251221007047	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
251221007048	dimer interface [polypeptide binding]; other site
251221007049	motif 1; other site
251221007050	active site
251221007051	motif 2; other site
251221007052	motif 3; other site
251221007053	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
251221007054	anticodon binding site; other site
251221007055	TIGR02652 family protein; Region: TIGR02652
251221007056	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
251221007057	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
251221007058	DXD motif; other site
251221007059	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
251221007060	Transposase, Mutator family; Region: Transposase_mut; cl19537
251221007061	Transposase, Mutator family; Region: Transposase_mut; cl19537
251221007062	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
251221007063	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
251221007064	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
251221007065	active site
251221007066	catalytic residues [active]
251221007067	OB-fold nucleic acid binding domain; Region: tRNA_anti-codon; pfam01336
251221007068	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
251221007069	dimer interface [polypeptide binding]; other site
251221007070	[2Fe-2S] cluster binding site [ion binding]; other site
251221007071	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
251221007072	Ferritin-like domain; Region: Ferritin; pfam00210
251221007073	dimerization interface [polypeptide binding]; other site
251221007074	DPS ferroxidase diiron center [ion binding]; other site
251221007075	ion pore; other site
251221007076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221007077	Walker A motif; other site
251221007078	ATP binding site [chemical binding]; other site
251221007079	Walker B motif; other site
251221007080	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
251221007081	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
251221007082	gamma subunit interface [polypeptide binding]; other site
251221007083	epsilon subunit interface [polypeptide binding]; other site
251221007084	LBP interface [polypeptide binding]; other site
251221007085	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
251221007086	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
251221007087	E3 interaction surface; other site
251221007088	lipoyl attachment site [posttranslational modification]; other site
251221007089	e3 binding domain; Region: E3_binding; pfam02817
251221007090	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
251221007091	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
251221007092	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
251221007093	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
251221007094	alpha subunit interaction interface [polypeptide binding]; other site
251221007095	Walker A motif; other site
251221007096	ATP binding site [chemical binding]; other site
251221007097	Walker B motif; other site
251221007098	inhibitor binding site; inhibition site
251221007099	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
251221007100	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
251221007101	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
251221007102	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
251221007103	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221007104	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
251221007105	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221007106	DNA binding residues [nucleotide binding]
251221007107	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
251221007108	O-Antigen ligase; Region: Wzy_C; pfam04932
251221007109	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
251221007110	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221007111	TPR motif; other site
251221007112	binding surface
251221007113	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221007114	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007115	putative active site [active]
251221007116	S-adenosylmethionine synthetase; Validated; Region: PRK05250
251221007117	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
251221007118	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
251221007119	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
251221007120	cell division protein; Validated; Region: ftsH; CHL00176
251221007121	FtsH Extracellular; Region: FtsH_ext; pfam06480
251221007122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221007123	Walker A motif; other site
251221007124	ATP binding site [chemical binding]; other site
251221007125	Walker B motif; other site
251221007126	arginine finger; other site
251221007127	Peptidase family M41; Region: Peptidase_M41; pfam01434
251221007128	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
251221007129	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
251221007130	putative active site [active]
251221007131	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
251221007132	putative active site [active]
251221007133	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
251221007134	active site
251221007135	SAM binding site [chemical binding]; other site
251221007136	homodimer interface [polypeptide binding]; other site
251221007137	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007138	putative active site [active]
251221007139	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
251221007140	homodimer interface [polypeptide binding]; other site
251221007141	substrate-cofactor binding pocket; other site
251221007142	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221007143	catalytic residue [active]
251221007144	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
251221007145	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
251221007146	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
251221007147	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
251221007148	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
251221007149	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
251221007150	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
251221007151	NAD synthetase; Provisional; Region: PRK13981
251221007152	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
251221007153	multimer interface [polypeptide binding]; other site
251221007154	active site
251221007155	catalytic triad [active]
251221007156	protein interface 1 [polypeptide binding]; other site
251221007157	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
251221007158	homodimer interface [polypeptide binding]; other site
251221007159	NAD binding pocket [chemical binding]; other site
251221007160	ATP binding pocket [chemical binding]; other site
251221007161	Mg binding site [ion binding]; other site
251221007162	active-site loop [active]
251221007163	Clp amino terminal domain; Region: Clp_N; pfam02861
251221007164	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007165	putative active site [active]
251221007166	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
251221007167	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
251221007168	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
251221007169	B12 binding site [chemical binding]; other site
251221007170	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
251221007171	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
251221007172	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
251221007173	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
251221007174	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
251221007175	putative SAM binding site [chemical binding]; other site
251221007176	putative homodimer interface [polypeptide binding]; other site
251221007177	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
251221007178	homodimer interface [polypeptide binding]; other site
251221007179	metal binding site [ion binding]; metal-binding site
251221007180	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
251221007181	homodimer interface [polypeptide binding]; other site
251221007182	active site
251221007183	putative chemical substrate binding site [chemical binding]; other site
251221007184	metal binding site [ion binding]; metal-binding site
251221007185	DEAD-like helicases superfamily; Region: DEXDc; smart00487
251221007186	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221007187	ATP binding site [chemical binding]; other site
251221007188	putative Mg++ binding site [ion binding]; other site
251221007189	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221007190	nucleotide binding region [chemical binding]; other site
251221007191	ATP-binding site [chemical binding]; other site
251221007192	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
251221007193	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
251221007194	active site
251221007195	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
251221007196	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
251221007197	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221007198	aspartate aminotransferase; Provisional; Region: PRK05764
251221007199	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
251221007200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221007201	homodimer interface [polypeptide binding]; other site
251221007202	catalytic residue [active]
251221007203	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
251221007204	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221007205	catalytic residue [active]
251221007206	2OG-Fe dioxygenase; Region: 2OG-Fe_Oxy_2; pfam10014
251221007207	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
251221007208	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
251221007209	Domain of unknown function (DUF4480); Region: DUF4480; pfam13715
251221007210	PIN domain; Region: PIN_3; cl17397
251221007211	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
251221007212	active site
251221007213	multifunctional aminopeptidase A; Provisional; Region: PRK00913
251221007214	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
251221007215	interface (dimer of trimers) [polypeptide binding]; other site
251221007216	Substrate-binding/catalytic site; other site
251221007217	Zn-binding sites [ion binding]; other site
251221007218	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
251221007219	substrate binding site [chemical binding]; other site
251221007220	active site
251221007221	catalytic residues [active]
251221007222	heterodimer interface [polypeptide binding]; other site
251221007223	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
251221007224	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
251221007225	putative active site cavity [active]
251221007226	GMP synthase; Reviewed; Region: guaA; PRK00074
251221007227	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
251221007228	AMP/PPi binding site [chemical binding]; other site
251221007229	candidate oxyanion hole; other site
251221007230	catalytic triad [active]
251221007231	potential glutamine specificity residues [chemical binding]; other site
251221007232	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
251221007233	ATP Binding subdomain [chemical binding]; other site
251221007234	Ligand Binding sites [chemical binding]; other site
251221007235	Dimerization subdomain; other site
251221007236	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007237	putative active site [active]
251221007238	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
251221007239	tellurite resistance protein terB; Region: terB; cd07176
251221007240	putative metal binding site [ion binding]; other site
251221007241	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007242	putative active site [active]
251221007243	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
251221007244	magnesium chelatase subunit H; Provisional; Region: PRK12493
251221007245	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
251221007246	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
251221007247	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
251221007248	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
251221007249	putative di-iron ligands [ion binding]; other site
251221007250	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
251221007251	active site
251221007252	catalytic site [active]
251221007253	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221007254	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221007255	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221007256	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221007257	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221007258	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221007259	GAF domain; Region: GAF; pfam01590
251221007260	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221007261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221007262	dimer interface [polypeptide binding]; other site
251221007263	phosphorylation site [posttranslational modification]
251221007264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221007265	ATP binding site [chemical binding]; other site
251221007266	Mg2+ binding site [ion binding]; other site
251221007267	G-X-G motif; other site
251221007268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
251221007269	Peptidase S46; Region: Peptidase_S46; pfam10459
251221007270	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
251221007271	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221007272	ATP binding site [chemical binding]; other site
251221007273	putative Mg++ binding site [ion binding]; other site
251221007274	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221007275	nucleotide binding region [chemical binding]; other site
251221007276	ATP-binding site [chemical binding]; other site
251221007277	RQC domain; Region: RQC; pfam09382
251221007278	HRDC domain; Region: HRDC; pfam00570
251221007279	Helix-turn-helix domain; Region: HTH_40; pfam14493
251221007280	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
251221007281	Domain of unknown function (DUF309); Region: DUF309; pfam03745
251221007282	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
251221007283	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
251221007284	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
251221007285	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
251221007286	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409
251221007287	G-X-X-G motif; other site
251221007288	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
251221007289	signal recognition particle protein; Provisional; Region: PRK10867
251221007290	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
251221007291	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
251221007292	P loop; other site
251221007293	GTP binding site [chemical binding]; other site
251221007294	Signal peptide binding domain; Region: SRP_SPB; pfam02978
251221007295	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
251221007296	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
251221007297	putative ribose interaction site [chemical binding]; other site
251221007298	putative ADP binding site [chemical binding]; other site
251221007299	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
251221007300	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
251221007301	active site
251221007302	nucleotide binding site [chemical binding]; other site
251221007303	HIGH motif; other site
251221007304	KMSKS motif; other site
251221007305	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
251221007306	active site
251221007307	Domain of unknown function (DUF892); Region: DUF892; cl17410
251221007308	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221007309	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
251221007310	phosphate binding site [ion binding]; other site
251221007311	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
251221007312	catalytic center binding site [active]
251221007313	ATP binding site [chemical binding]; other site
251221007314	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
251221007315	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221007316	Coenzyme A binding pocket [chemical binding]; other site
251221007317	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
251221007318	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
251221007319	dimerization interface [polypeptide binding]; other site
251221007320	active site
251221007321	metal binding site [ion binding]; metal-binding site
251221007322	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
251221007323	dsRNA binding site [nucleotide binding]; other site
251221007324	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221007325	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
251221007326	Walker A motif; other site
251221007327	ATP binding site [chemical binding]; other site
251221007328	Walker B motif; other site
251221007329	arginine finger; other site
251221007330	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
251221007331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221007332	Walker A motif; other site
251221007333	ATP binding site [chemical binding]; other site
251221007334	Walker B motif; other site
251221007335	arginine finger; other site
251221007336	Peptidase family M41; Region: Peptidase_M41; pfam01434
251221007337	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221007338	TPR motif; other site
251221007339	binding surface
251221007340	Protein of unknown function (DUF448); Region: DUF448; pfam04296
251221007341	putative RNA binding cleft [nucleotide binding]; other site
251221007342	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
251221007343	translation initiation factor IF-2; Region: IF-2; TIGR00487
251221007344	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
251221007345	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
251221007346	G1 box; other site
251221007347	putative GEF interaction site [polypeptide binding]; other site
251221007348	GTP/Mg2+ binding site [chemical binding]; other site
251221007349	Switch I region; other site
251221007350	G2 box; other site
251221007351	G3 box; other site
251221007352	Switch II region; other site
251221007353	G4 box; other site
251221007354	G5 box; other site
251221007355	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
251221007356	Translation-initiation factor 2; Region: IF-2; pfam11987
251221007357	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
251221007358	AAA ATPase domain; Region: AAA_16; pfam13191
251221007359	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221007360	structural tetrad; other site
251221007361	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221007362	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221007363	structural tetrad; other site
251221007364	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
251221007365	pheophytin binding site; other site
251221007366	chlorophyll binding site; other site
251221007367	quinone binding site; other site
251221007368	Fe binding site [ion binding]; other site
251221007369	ketol-acid reductoisomerase; Provisional; Region: PRK05479
251221007370	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
251221007371	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
251221007372	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
251221007373	PA/protease domain interface [polypeptide binding]; other site
251221007374	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
251221007375	putative integrin binding motif; other site
251221007376	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
251221007377	metal binding site [ion binding]; metal-binding site
251221007378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221007379	binding surface
251221007380	TPR motif; other site
251221007381	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
251221007382	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
251221007383	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
251221007384	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007385	putative active site [active]
251221007386	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
251221007387	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
251221007388	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
251221007389	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221007390	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
251221007391	Walker A motif; other site
251221007392	ATP binding site [chemical binding]; other site
251221007393	Walker B motif; other site
251221007394	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
251221007395	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
251221007396	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
251221007397	Walker A motif; other site
251221007398	ATP binding site [chemical binding]; other site
251221007399	Walker B motif; other site
251221007400	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
251221007401	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221007402	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
251221007403	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221007404	DNA binding residues [nucleotide binding]
251221007405	Ycf27; Reviewed; Region: orf27; CHL00148
251221007406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221007407	active site
251221007408	phosphorylation site [posttranslational modification]
251221007409	intermolecular recognition site; other site
251221007410	dimerization interface [polypeptide binding]; other site
251221007411	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221007412	DNA binding site [nucleotide binding]
251221007413	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
251221007414	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221007415	catalytic residue [active]
251221007416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221007417	S-adenosylmethionine binding site [chemical binding]; other site
251221007418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
251221007419	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221007420	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221007421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221007422	Walker A/P-loop; other site
251221007423	ATP binding site [chemical binding]; other site
251221007424	Q-loop/lid; other site
251221007425	ABC transporter signature motif; other site
251221007426	Walker B; other site
251221007427	D-loop; other site
251221007428	H-loop/switch region; other site
251221007429	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007430	putative active site [active]
251221007431	putative transposase OrfB; Reviewed; Region: PHA02517
251221007432	HTH-like domain; Region: HTH_21; pfam13276
251221007433	Integrase core domain; Region: rve; pfam00665
251221007434	Integrase core domain; Region: rve_3; pfam13683
251221007435	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
251221007436	Transposase; Region: HTH_Tnp_1; cl17663
251221007437	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
251221007438	Integrase core domain; Region: rve; pfam00665
251221007439	TfoX N-terminal domain; Region: TfoX_N; pfam04993
251221007440	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
251221007441	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
251221007442	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
251221007443	active site
251221007444	iron coordination sites [ion binding]; other site
251221007445	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
251221007446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
251221007447	putative DNA binding site [nucleotide binding]; other site
251221007448	putative Zn2+ binding site [ion binding]; other site
251221007449	AsnC family; Region: AsnC_trans_reg; pfam01037
251221007450	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221007451	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
251221007452	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
251221007453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221007454	Coenzyme A binding pocket [chemical binding]; other site
251221007455	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221007456	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221007457	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
251221007458	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
251221007459	iron-sulfur cluster [ion binding]; other site
251221007460	[2Fe-2S] cluster binding site [ion binding]; other site
251221007461	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
251221007462	hydrophobic ligand binding site; other site
251221007463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
251221007464	Protein of unknown function (DUF433); Region: DUF433; pfam04255
251221007465	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221007466	Ligand Binding Site [chemical binding]; other site
251221007467	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
251221007468	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
251221007469	phosphoenolpyruvate synthase; Validated; Region: PRK06241
251221007470	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221007471	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
251221007472	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
251221007473	TM-ABC transporter signature motif; other site
251221007474	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221007475	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
251221007476	active site
251221007477	catalytic tetrad [active]
251221007478	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
251221007479	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
251221007480	putative C-terminal domain interface [polypeptide binding]; other site
251221007481	putative GSH binding site (G-site) [chemical binding]; other site
251221007482	putative dimer interface [polypeptide binding]; other site
251221007483	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
251221007484	N-terminal domain interface [polypeptide binding]; other site
251221007485	dimer interface [polypeptide binding]; other site
251221007486	substrate binding pocket (H-site) [chemical binding]; other site
251221007487	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
251221007488	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
251221007489	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
251221007490	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
251221007491	[2Fe-2S] cluster binding site [ion binding]; other site
251221007492	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
251221007493	alpha subunit interface [polypeptide binding]; other site
251221007494	active site
251221007495	substrate binding site [chemical binding]; other site
251221007496	Fe binding site [ion binding]; other site
251221007497	NHL repeat; Region: NHL; pfam01436
251221007498	NHL repeat; Region: NHL; pfam01436
251221007499	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
251221007500	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
251221007501	putative dimer interface [polypeptide binding]; other site
251221007502	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
251221007503	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
251221007504	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
251221007505	homotrimer interaction site [polypeptide binding]; other site
251221007506	active site
251221007507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221007508	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
251221007509	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
251221007510	RNA polymerase sigma factor; Provisional; Region: PRK12519
251221007511	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221007512	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221007513	DNA binding residues [nucleotide binding]
251221007514	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
251221007515	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
251221007516	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
251221007517	ADP binding site [chemical binding]; other site
251221007518	magnesium binding site [ion binding]; other site
251221007519	putative shikimate binding site; other site
251221007520	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
251221007521	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
251221007522	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
251221007523	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
251221007524	trimer interface [polypeptide binding]; other site
251221007525	active site
251221007526	UDP-GlcNAc binding site [chemical binding]; other site
251221007527	lipid binding site [chemical binding]; lipid-binding site
251221007528	light-harvesting-like protein 3; Provisional; Region: PLN00014
251221007529	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
251221007530	active site
251221007531	dimer interface [polypeptide binding]; other site
251221007532	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl19308
251221007533	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
251221007534	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
251221007535	active site
251221007536	metal binding site [ion binding]; metal-binding site
251221007537	AAA domain; Region: AAA_30; pfam13604
251221007538	Acyltransferase family; Region: Acyl_transf_3; pfam01757
251221007539	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221007540	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221007541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221007542	Walker A/P-loop; other site
251221007543	ATP binding site [chemical binding]; other site
251221007544	Q-loop/lid; other site
251221007545	ABC transporter signature motif; other site
251221007546	Walker B; other site
251221007547	D-loop; other site
251221007548	H-loop/switch region; other site
251221007549	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221007550	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221007551	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221007552	Walker A/P-loop; other site
251221007553	ATP binding site [chemical binding]; other site
251221007554	Q-loop/lid; other site
251221007555	ABC transporter signature motif; other site
251221007556	Walker B; other site
251221007557	D-loop; other site
251221007558	H-loop/switch region; other site
251221007559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221007560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221007561	TPR motif; other site
251221007562	binding surface
251221007563	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221007564	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221007565	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
251221007566	RES domain; Region: RES; cl02411
251221007567	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
251221007568	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
251221007569	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
251221007570	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
251221007571	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
251221007572	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
251221007573	catalytic loop [active]
251221007574	iron binding site [ion binding]; other site
251221007575	putative addiction module antidote; Region: doc_partner; TIGR02609
251221007576	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
251221007577	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
251221007578	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221007579	ATP binding site [chemical binding]; other site
251221007580	putative Mg++ binding site [ion binding]; other site
251221007581	Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201
251221007582	helicase superfamily c-terminal domain; Region: HELICc; smart00490
251221007583	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
251221007584	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
251221007585	putative active site [active]
251221007586	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
251221007587	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
251221007588	Part of AAA domain; Region: AAA_19; pfam13245
251221007589	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
251221007590	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
251221007591	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
251221007592	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
251221007593	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221007594	ATP binding site [chemical binding]; other site
251221007595	putative Mg++ binding site [ion binding]; other site
251221007596	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221007597	nucleotide binding region [chemical binding]; other site
251221007598	ATP-binding site [chemical binding]; other site
251221007599	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
251221007600	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
251221007601	Probable transposase; Region: OrfB_IS605; pfam01385
251221007602	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
251221007603	TPR repeat; Region: TPR_11; pfam13414
251221007604	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221007605	TPR motif; other site
251221007606	binding surface
251221007607	Tetratricopeptide repeat; Region: TPR_16; pfam13432
251221007608	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
251221007609	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221007610	active site
251221007611	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
251221007612	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
251221007613	Zn2+ binding site [ion binding]; other site
251221007614	Mg2+ binding site [ion binding]; other site
251221007615	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
251221007616	synthetase active site [active]
251221007617	NTP binding site [chemical binding]; other site
251221007618	metal binding site [ion binding]; metal-binding site
251221007619	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
251221007620	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
251221007621	PAS fold; Region: PAS_4; pfam08448
251221007622	GAF domain; Region: GAF_2; pfam13185
251221007623	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221007624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221007625	dimer interface [polypeptide binding]; other site
251221007626	phosphorylation site [posttranslational modification]
251221007627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221007628	ATP binding site [chemical binding]; other site
251221007629	Mg2+ binding site [ion binding]; other site
251221007630	G-X-G motif; other site
251221007631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221007632	active site
251221007633	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
251221007634	phosphorylation site [posttranslational modification]
251221007635	intermolecular recognition site; other site
251221007636	dimerization interface [polypeptide binding]; other site
251221007637	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
251221007638	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221007639	putative active site [active]
251221007640	heme pocket [chemical binding]; other site
251221007641	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221007642	putative active site [active]
251221007643	heme pocket [chemical binding]; other site
251221007644	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221007645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221007646	dimer interface [polypeptide binding]; other site
251221007647	phosphorylation site [posttranslational modification]
251221007648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221007649	ATP binding site [chemical binding]; other site
251221007650	Mg2+ binding site [ion binding]; other site
251221007651	G-X-G motif; other site
251221007652	conserved domain; Region: TIGR02271
251221007653	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
251221007654	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
251221007655	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
251221007656	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
251221007657	Proline dehydrogenase; Region: Pro_dh; pfam01619
251221007658	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
251221007659	Glutamate binding site [chemical binding]; other site
251221007660	homodimer interface [polypeptide binding]; other site
251221007661	NAD binding site [chemical binding]; other site
251221007662	catalytic residues [active]
251221007663	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
251221007664	active site
251221007665	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
251221007666	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221007667	catalytic residue [active]
251221007668	Domain of unknown function DUF20; Region: UPF0118; cl00465
251221007669	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
251221007670	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221007671	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
251221007672	Protein of unknown function (DUF952); Region: DUF952; pfam06108
251221007673	GTP-binding protein LepA; Provisional; Region: PRK05433
251221007674	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
251221007675	G1 box; other site
251221007676	putative GEF interaction site [polypeptide binding]; other site
251221007677	GTP/Mg2+ binding site [chemical binding]; other site
251221007678	Switch I region; other site
251221007679	G2 box; other site
251221007680	G3 box; other site
251221007681	Switch II region; other site
251221007682	G4 box; other site
251221007683	G5 box; other site
251221007684	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
251221007685	Elongation Factor G, domain II; Region: EFG_II; pfam14492
251221007686	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
251221007687	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
251221007688	SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833
251221007689	active site
251221007690	catalytic triad [active]
251221007691	oxyanion hole [active]
251221007692	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221007693	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221007694	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221007695	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
251221007696	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
251221007697	HipA-like N-terminal domain; Region: HipA_N; pfam07805
251221007698	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
251221007699	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
251221007700	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
251221007701	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
251221007702	dimer interface [polypeptide binding]; other site
251221007703	active site
251221007704	heme binding site [chemical binding]; other site
251221007705	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
251221007706	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
251221007707	nudix motif; other site
251221007708	TPR repeat; Region: TPR_11; pfam13414
251221007709	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221007710	TPR motif; other site
251221007711	TPR repeat; Region: TPR_11; pfam13414
251221007712	binding surface
251221007713	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
251221007714	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
251221007715	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
251221007716	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221007717	FeS/SAM binding site; other site
251221007718	Protein of unknown function (DUF512); Region: DUF512; pfam04459
251221007719	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221007720	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221007721	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
251221007722	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221007723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221007724	S-adenosylmethionine binding site [chemical binding]; other site
251221007725	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
251221007726	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
251221007727	Ligand binding site; other site
251221007728	Putative Catalytic site; other site
251221007729	DXD motif; other site
251221007730	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
251221007731	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
251221007732	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
251221007733	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
251221007734	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
251221007735	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
251221007736	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221007737	active site
251221007738	motif I; other site
251221007739	motif II; other site
251221007740	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007741	putative active site [active]
251221007742	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
251221007743	Cytochrome c; Region: Cytochrom_C; cl11414
251221007744	Cytochrome c; Region: Cytochrom_C; pfam00034
251221007745	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
251221007746	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
251221007747	substrate binding pocket [chemical binding]; other site
251221007748	membrane-bound complex binding site; other site
251221007749	hinge residues; other site
251221007750	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
251221007751	23S rRNA binding site [nucleotide binding]; other site
251221007752	L21 binding site [polypeptide binding]; other site
251221007753	L13 binding site [polypeptide binding]; other site
251221007754	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
251221007755	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
251221007756	hypothetical protein; Provisional; Region: PRK01346
251221007757	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221007758	Coenzyme A binding pocket [chemical binding]; other site
251221007759	Sterol carrier protein domain; Region: SCP2_2; pfam13530
251221007760	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
251221007761	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
251221007762	Zn binding site [ion binding]; other site
251221007763	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
251221007764	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221007765	active site
251221007766	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
251221007767	substrate binding site; other site
251221007768	dimer interface; other site
251221007769	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
251221007770	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221007771	putative active site [active]
251221007772	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
251221007773	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
251221007774	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
251221007775	Lipopolysaccharide-assembly, LptC-related; Region: LptC; cl01200
251221007776	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
251221007777	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
251221007778	active site
251221007779	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221007780	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221007781	active site
251221007782	phosphorylation site [posttranslational modification]
251221007783	dimerization interface [polypeptide binding]; other site
251221007784	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221007785	DNA binding site [nucleotide binding]
251221007786	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221007787	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
251221007788	ligand binding site [chemical binding]; other site
251221007789	flexible hinge region; other site
251221007790	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
251221007791	putative switch regulator; other site
251221007792	non-specific DNA interactions [nucleotide binding]; other site
251221007793	DNA binding site [nucleotide binding]
251221007794	sequence specific DNA binding site [nucleotide binding]; other site
251221007795	putative cAMP binding site [chemical binding]; other site
251221007796	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
251221007797	active site
251221007798	catalytic site [active]
251221007799	Domain of unknown function (DUF4415); Region: DUF4415; cl01401
251221007800	acetolactate synthase; Reviewed; Region: PRK08322
251221007801	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
251221007802	PYR/PP interface [polypeptide binding]; other site
251221007803	dimer interface [polypeptide binding]; other site
251221007804	TPP binding site [chemical binding]; other site
251221007805	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
251221007806	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
251221007807	TPP-binding site [chemical binding]; other site
251221007808	dimer interface [polypeptide binding]; other site
251221007809	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
251221007810	NAD(P) binding site [chemical binding]; other site
251221007811	catalytic residues [active]
251221007812	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221007813	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221007814	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221007815	photosystem II reaction center protein K; Provisional; Region: psbK; PRK02553
251221007816	tellurium resistance terB-like protein; Region: terB_like; cd07177
251221007817	metal binding site [ion binding]; metal-binding site
251221007818	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
251221007819	haloalkane dehalogenase; Provisional; Region: PRK03592
251221007820	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221007821	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
251221007822	Strictosidine synthase; Region: Str_synth; cl19733
251221007823	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
251221007824	elongation factor G; Reviewed; Region: PRK12740
251221007825	G1 box; other site
251221007826	putative GEF interaction site [polypeptide binding]; other site
251221007827	GTP/Mg2+ binding site [chemical binding]; other site
251221007828	Switch I region; other site
251221007829	G2 box; other site
251221007830	G3 box; other site
251221007831	Switch II region; other site
251221007832	G4 box; other site
251221007833	G5 box; other site
251221007834	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
251221007835	Elongation Factor G, domain II; Region: EFG_II; pfam14492
251221007836	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
251221007837	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
251221007838	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
251221007839	intracellular protease, PfpI family; Region: PfpI; TIGR01382
251221007840	proposed catalytic triad [active]
251221007841	conserved cys residue [active]
251221007842	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
251221007843	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221007844	S-adenosylmethionine binding site [chemical binding]; other site
251221007845	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
251221007846	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
251221007847	AAA domain; Region: AAA_33; pfam13671
251221007848	ATP-binding site [chemical binding]; other site
251221007849	Gluconate-6-phosphate binding site [chemical binding]; other site
251221007850	Ferritin-like domain; Region: Ferritin; pfam00210
251221007851	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
251221007852	dimerization interface [polypeptide binding]; other site
251221007853	DPS ferroxidase diiron center [ion binding]; other site
251221007854	ion pore; other site
251221007855	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
251221007856	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
251221007857	NAD binding site [chemical binding]; other site
251221007858	homodimer interface [polypeptide binding]; other site
251221007859	active site
251221007860	substrate binding site [chemical binding]; other site
251221007861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221007862	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221007863	WD domain, G-beta repeat; Region: WD40; pfam00400
251221007864	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221007865	structural tetrad; other site
251221007866	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221007867	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221007868	structural tetrad; other site
251221007869	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221007870	WD40 repeats; Region: WD40; smart00320
251221007871	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
251221007872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221007873	putative substrate translocation pore; other site
251221007874	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
251221007875	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
251221007876	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
251221007877	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221007878	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
251221007879	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
251221007880	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
251221007881	NAD(P) binding site [chemical binding]; other site
251221007882	hypothetical protein; Provisional; Region: PRK06185
251221007883	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221007884	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
251221007885	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
251221007886	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221007887	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
251221007888	active site
251221007889	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
251221007890	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
251221007891	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
251221007892	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
251221007893	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
251221007894	FMN binding site [chemical binding]; other site
251221007895	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
251221007896	substrate binding site [chemical binding]; other site
251221007897	putative catalytic residue [active]
251221007898	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
251221007899	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
251221007900	active site
251221007901	Acyl transferase domain; Region: Acyl_transf_1; cl08282
251221007902	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
251221007903	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221007904	NAD(P) binding site [chemical binding]; other site
251221007905	active site
251221007906	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
251221007907	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
251221007908	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
251221007909	Cinnamyl alcohol dehydrogenases (CAD) and related proteins; Region: CAD; cd08245
251221007910	NAD binding site [chemical binding]; other site
251221007911	substrate binding site [chemical binding]; other site
251221007912	catalytic Zn binding site [ion binding]; other site
251221007913	structural Zn binding site [ion binding]; other site
251221007914	tetramer interface [polypeptide binding]; other site
251221007915	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
251221007916	short chain dehydrogenase; Provisional; Region: PRK06172
251221007917	classical (c) SDRs; Region: SDR_c; cd05233
251221007918	NAD(P) binding site [chemical binding]; other site
251221007919	active site
251221007920	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
251221007921	MMPL family; Region: MMPL; cl14618
251221007922	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221007923	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221007924	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221007925	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
251221007926	active site
251221007927	catalytic tetrad [active]
251221007928	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
251221007929	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
251221007930	tetramer interface [polypeptide binding]; other site
251221007931	TPP-binding site [chemical binding]; other site
251221007932	heterodimer interface [polypeptide binding]; other site
251221007933	phosphorylation loop region [posttranslational modification]
251221007934	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
251221007935	tetramerization interface [polypeptide binding]; other site
251221007936	active site
251221007937	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
251221007938	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
251221007939	alpha subunit interface [polypeptide binding]; other site
251221007940	TPP binding site [chemical binding]; other site
251221007941	heterodimer interface [polypeptide binding]; other site
251221007942	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
251221007943	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221007944	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
251221007945	active site
251221007946	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
251221007947	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
251221007948	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
251221007949	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
251221007950	short chain dehydrogenase; Region: adh_short; pfam00106
251221007951	putative NADP binding site [chemical binding]; other site
251221007952	active site
251221007953	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
251221007954	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
251221007955	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221007956	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
251221007957	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
251221007958	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
251221007959	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
251221007960	active site
251221007961	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
251221007962	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
251221007963	dimer interface [polypeptide binding]; other site
251221007964	active site
251221007965	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
251221007966	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221007967	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
251221007968	Transcriptional regulator [Transcription]; Region: LysR; COG0583
251221007969	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221007970	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
251221007971	dimerization interface [polypeptide binding]; other site
251221007972	Uncharacterized conserved protein [Function unknown]; Region: COG1359
251221007973	short chain dehydrogenase; Provisional; Region: PRK06172
251221007974	classical (c) SDRs; Region: SDR_c; cd05233
251221007975	NAD(P) binding site [chemical binding]; other site
251221007976	active site
251221007977	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
251221007978	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
251221007979	NAD(P) binding site [chemical binding]; other site
251221007980	LysR family transcriptional regulator; Provisional; Region: PRK14997
251221007981	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221007982	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
251221007983	putative effector binding pocket; other site
251221007984	dimerization interface [polypeptide binding]; other site
251221007985	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
251221007986	dinuclear metal binding motif [ion binding]; other site
251221007987	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
251221007988	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221007989	Walker A/P-loop; other site
251221007990	ATP binding site [chemical binding]; other site
251221007991	Q-loop/lid; other site
251221007992	Rad50 zinc hook motif; Region: Rad50_zn_hook; pfam04423
251221007993	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
251221007994	ABC transporter signature motif; other site
251221007995	Walker B; other site
251221007996	D-loop; other site
251221007997	H-loop/switch region; other site
251221007998	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
251221007999	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
251221008000	DNA binding residues [nucleotide binding]
251221008001	putative dimer interface [polypeptide binding]; other site
251221008002	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
251221008003	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221008004	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
251221008005	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
251221008006	Di-iron ligands [ion binding]; other site
251221008007	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221008008	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221008009	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
251221008010	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221008011	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221008012	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
251221008013	Walker A/P-loop; other site
251221008014	ATP binding site [chemical binding]; other site
251221008015	Q-loop/lid; other site
251221008016	ABC transporter signature motif; other site
251221008017	Walker B; other site
251221008018	D-loop; other site
251221008019	H-loop/switch region; other site
251221008020	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
251221008021	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
251221008022	mercuric reductase; Validated; Region: PRK06370
251221008023	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221008024	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
251221008025	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
251221008026	Acyltransferase family; Region: Acyl_transf_3; cl19154
251221008027	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
251221008028	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
251221008029	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
251221008030	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
251221008031	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
251221008032	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
251221008033	NifU-like domain; Region: NifU; pfam01106
251221008034	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221008035	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
251221008036	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
251221008037	Ycf35; Provisional; Region: ycf35; CHL00193
251221008038	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
251221008039	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
251221008040	CAAX protease self-immunity; Region: Abi; pfam02517
251221008041	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
251221008042	RuvA N terminal domain; Region: RuvA_N; pfam01330
251221008043	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
251221008044	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
251221008045	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
251221008046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
251221008047	putative active site [active]
251221008048	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
251221008049	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
251221008050	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
251221008051	active site
251221008052	dimer interface [polypeptide binding]; other site
251221008053	motif 1; other site
251221008054	motif 2; other site
251221008055	motif 3; other site
251221008056	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
251221008057	anticodon binding site; other site
251221008058	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
251221008059	active site
251221008060	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
251221008061	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
251221008062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221008063	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221008064	structural tetrad; other site
251221008065	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221008066	WD domain, G-beta repeat; Region: WD40; pfam00400
251221008067	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221008068	structural tetrad; other site
251221008069	WD domain, G-beta repeat; Region: WD40; pfam00400
251221008070	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221008071	Predicted transcriptional regulator [Transcription]; Region: COG2378
251221008072	HTH domain; Region: HTH_11; cl17392
251221008073	WYL domain; Region: WYL; pfam13280
251221008074	SnoaL-like domain; Region: SnoaL_2; pfam12680
251221008075	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
251221008076	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
251221008077	NADP binding site [chemical binding]; other site
251221008078	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
251221008079	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008080	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008081	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008082	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008083	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008084	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008085	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
251221008086	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221008087	DNA binding residues [nucleotide binding]
251221008088	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221008089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221008090	binding surface
251221008091	TPR motif; other site
251221008092	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221008093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221008094	binding surface
251221008095	TPR motif; other site
251221008096	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221008097	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221008098	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221008099	binding surface
251221008100	TPR motif; other site
251221008101	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221008102	CHAT domain; Region: CHAT; pfam12770
251221008103	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
251221008104	oligomerisation interface [polypeptide binding]; other site
251221008105	mobile loop; other site
251221008106	roof hairpin; other site
251221008107	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
251221008108	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
251221008109	ring oligomerisation interface [polypeptide binding]; other site
251221008110	ATP/Mg binding site [chemical binding]; other site
251221008111	stacking interactions; other site
251221008112	hinge regions; other site
251221008113	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
251221008114	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
251221008115	Walker A/P-loop; other site
251221008116	ATP binding site [chemical binding]; other site
251221008117	Q-loop/lid; other site
251221008118	ABC transporter signature motif; other site
251221008119	Walker B; other site
251221008120	D-loop; other site
251221008121	H-loop/switch region; other site
251221008122	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
251221008123	putative active site [active]
251221008124	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
251221008125	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
251221008126	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
251221008127	MltA specific insert domain; Region: MltA; smart00925
251221008128	3D domain; Region: 3D; cl01439
251221008129	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
251221008130	Mechanosensitive ion channel; Region: MS_channel; pfam00924
251221008131	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
251221008132	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
251221008133	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
251221008134	beta subunit interaction interface [polypeptide binding]; other site
251221008135	Walker A motif; other site
251221008136	ATP binding site [chemical binding]; other site
251221008137	Walker B motif; other site
251221008138	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
251221008139	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
251221008140	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
251221008141	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
251221008142	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
251221008143	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
251221008144	F0F1 ATP synthase subunit C; Validated; Region: PRK07354
251221008145	ATP synthase CF0 A subunit; Region: atpI; CHL00046
251221008146	CobD/Cbib protein; Region: CobD_Cbib; cl00561
251221008147	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
251221008148	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
251221008149	active site
251221008150	WG containing repeat; Region: WG_beta_rep; pfam14903
251221008151	WG containing repeat; Region: WG_beta_rep; pfam14903
251221008152	WG containing repeat; Region: WG_beta_rep; pfam14903
251221008153	WG containing repeat; Region: WG_beta_rep; pfam14903
251221008154	WG containing repeat; Region: WG_beta_rep; pfam14903
251221008155	WG containing repeat; Region: WG_beta_rep; pfam14903
251221008156	WG containing repeat; Region: WG_beta_rep; pfam14903
251221008157	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
251221008158	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
251221008159	active site
251221008160	HIGH motif; other site
251221008161	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
251221008162	KMSKS motif; other site
251221008163	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
251221008164	tRNA binding surface [nucleotide binding]; other site
251221008165	anticodon binding site; other site
251221008166	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
251221008167	Histidyl-tRNA synthetase; Region: PLN02972
251221008168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221008169	S-adenosylmethionine binding site [chemical binding]; other site
251221008170	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
251221008171	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
251221008172	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
251221008173	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
251221008174	active site
251221008175	NTP binding site [chemical binding]; other site
251221008176	metal binding triad [ion binding]; metal-binding site
251221008177	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
251221008178	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
251221008179	Zn2+ binding site [ion binding]; other site
251221008180	Mg2+ binding site [ion binding]; other site
251221008181	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
251221008182	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
251221008183	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
251221008184	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
251221008185	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
251221008186	putative tRNA-binding site [nucleotide binding]; other site
251221008187	B3/4 domain; Region: B3_4; pfam03483
251221008188	tRNA synthetase B5 domain; Region: B5; smart00874
251221008189	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
251221008190	dimer interface [polypeptide binding]; other site
251221008191	motif 1; other site
251221008192	motif 3; other site
251221008193	motif 2; other site
251221008194	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
251221008195	MraW methylase family; Region: Methyltransf_5; cl17771
251221008196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221008197	S-adenosylmethionine binding site [chemical binding]; other site
251221008198	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
251221008199	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
251221008200	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
251221008201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221008202	S-adenosylmethionine binding site [chemical binding]; other site
251221008203	Uncharacterized conserved protein [Function unknown]; Region: COG2442
251221008204	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
251221008205	ANP binding site [chemical binding]; other site
251221008206	Substrate Binding Site II [chemical binding]; other site
251221008207	Substrate Binding Site I [chemical binding]; other site
251221008208	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
251221008209	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
251221008210	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
251221008211	HAD-hyrolase-like; Region: Hydrolase_like; cl19142
251221008212	L-asparaginase II; Region: Asparaginase_II; pfam06089
251221008213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
251221008214	conserved hypothetical protein; Region: TIGR03492
251221008215	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
251221008216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
251221008217	Protein of unknown function; Region: DUF3971; pfam13116
251221008218	Family of unknown function (DUF490); Region: DUF490; pfam04357
251221008219	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
251221008220	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
251221008221	dimer interface [polypeptide binding]; other site
251221008222	ssDNA binding site [nucleotide binding]; other site
251221008223	tetramer (dimer of dimers) interface [polypeptide binding]; other site
251221008224	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
251221008225	putative active site [active]
251221008226	catalytic triad [active]
251221008227	dimer interface [polypeptide binding]; other site
251221008228	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
251221008229	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
251221008230	catalytic loop [active]
251221008231	iron binding site [ion binding]; other site
251221008232	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
251221008233	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
251221008234	Cysteine-rich domain; Region: CCG; pfam02754
251221008235	Cysteine-rich domain; Region: CCG; pfam02754
251221008236	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
251221008237	Protein of unknown function (DUF2656); Region: DUF2656; pfam10847
251221008238	AAA domain; Region: AAA_30; pfam13604
251221008239	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
251221008240	AAA domain; Region: AAA_12; pfam13087
251221008241	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
251221008242	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221008243	FeS/SAM binding site; other site
251221008244	Protein of unknown function (DUF433); Region: DUF433; pfam04255
251221008245	Protein of unknown function (DUF433); Region: DUF433; pfam04255
251221008246	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008247	putative active site [active]
251221008248	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
251221008249	Calcium binding; Region: Calci_bind_CcbP; pfam11535
251221008250	Tubulin like; Region: Tubulin_2; pfam13809
251221008251	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
251221008252	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
251221008253	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
251221008254	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
251221008255	Nuclease-related domain; Region: NERD; pfam08378
251221008256	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
251221008257	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008258	putative active site [active]
251221008259	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
251221008260	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
251221008261	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
251221008262	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221008263	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
251221008264	Penicillinase repressor; Region: Penicillinase_R; pfam03965
251221008265	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
251221008266	HEAT repeats; Region: HEAT_2; pfam13646
251221008267	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
251221008268	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
251221008269	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
251221008270	PIN domain; Region: PIN_2; pfam10130
251221008271	Transposase domain (DUF772); Region: DUF772; pfam05598
251221008272	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
251221008273	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
251221008274	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
251221008275	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221008276	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
251221008277	dimerization interface [polypeptide binding]; other site
251221008278	substrate binding pocket [chemical binding]; other site
251221008279	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
251221008280	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
251221008281	L-aspartate oxidase; Provisional; Region: PRK06175
251221008282	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
251221008283	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008284	putative active site [active]
251221008285	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008286	putative active site [active]
251221008287	hypothetical protein; Region: PHA00664
251221008288	PhoD-like phosphatase; Region: PhoD; pfam09423
251221008289	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
251221008290	putative active site [active]
251221008291	putative metal binding site [ion binding]; other site
251221008292	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
251221008293	YacP-like NYN domain; Region: NYN_YacP; pfam05991
251221008294	pantothenate kinase; Reviewed; Region: PRK13331
251221008295	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
251221008296	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
251221008297	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
251221008298	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221008299	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221008300	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
251221008301	catalytic loop [active]
251221008302	iron binding site [ion binding]; other site
251221008303	photosystem II chlorophyll-binding protein CP47; Region: PS_II_CP47; TIGR03039
251221008304	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
251221008305	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
251221008306	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
251221008307	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
251221008308	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
251221008309	HEAT repeats; Region: HEAT_2; pfam13646
251221008310	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
251221008311	HEAT repeats; Region: HEAT_2; pfam13646
251221008312	HEAT repeats; Region: HEAT_2; pfam13646
251221008313	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
251221008314	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
251221008315	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
251221008316	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221008317	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
251221008318	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221008319	DNA binding residues [nucleotide binding]
251221008320	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
251221008321	putative acyl-acceptor binding pocket; other site
251221008322	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
251221008323	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
251221008324	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
251221008325	active site
251221008326	HIGH motif; other site
251221008327	dimer interface [polypeptide binding]; other site
251221008328	KMSKS motif; other site
251221008329	citrate synthase; Provisional; Region: PRK14036
251221008330	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
251221008331	oxalacetate binding site [chemical binding]; other site
251221008332	citrylCoA binding site [chemical binding]; other site
251221008333	coenzyme A binding site [chemical binding]; other site
251221008334	catalytic triad [active]
251221008335	Domain of unknown function (DUF4440); Region: DUF4440; pfam14534
251221008336	Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838
251221008337	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221008338	catalytic residue [active]
251221008339	Competence protein J (ComJ); Region: ComJ; pfam11033
251221008340	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
251221008341	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
251221008342	putative NAD(P) binding site [chemical binding]; other site
251221008343	putative substrate binding site [chemical binding]; other site
251221008344	catalytic Zn binding site [ion binding]; other site
251221008345	structural Zn binding site [ion binding]; other site
251221008346	dimer interface [polypeptide binding]; other site
251221008347	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
251221008348	RIP metalloprotease RseP; Region: TIGR00054
251221008349	active site
251221008350	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
251221008351	putative substrate binding region [chemical binding]; other site
251221008352	PIN domain; Region: PIN_2; pfam10130
251221008353	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
251221008354	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
251221008355	C-terminal domain interface [polypeptide binding]; other site
251221008356	GSH binding site (G-site) [chemical binding]; other site
251221008357	dimer interface [polypeptide binding]; other site
251221008358	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
251221008359	N-terminal domain interface [polypeptide binding]; other site
251221008360	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
251221008361	putative SAM binding site [chemical binding]; other site
251221008362	putative homodimer interface [polypeptide binding]; other site
251221008363	Uncharacterized conserved protein [Function unknown]; Region: COG1432
251221008364	LabA_like proteins; Region: LabA; cd10911
251221008365	putative metal binding site [ion binding]; other site
251221008366	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
251221008367	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
251221008368	active site
251221008369	HIGH motif; other site
251221008370	KMSKS motif; other site
251221008371	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
251221008372	tRNA binding surface [nucleotide binding]; other site
251221008373	anticodon binding site; other site
251221008374	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
251221008375	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221008376	FeS/SAM binding site; other site
251221008377	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
251221008378	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
251221008379	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
251221008380	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
251221008381	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221008382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221008383	S-adenosylmethionine binding site [chemical binding]; other site
251221008384	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
251221008385	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221008386	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
251221008387	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
251221008388	Sm and related proteins; Region: Sm_like; cl00259
251221008389	heptamer interface [polypeptide binding]; other site
251221008390	Sm1 motif; other site
251221008391	hexamer interface [polypeptide binding]; other site
251221008392	RNA binding site [nucleotide binding]; other site
251221008393	Sm2 motif; other site
251221008394	Domain of unknown function (DUF362); Region: DUF362; cl19822
251221008395	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221008396	active site
251221008397	catalytic tetrad [active]
251221008398	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008399	putative active site [active]
251221008400	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221008401	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
251221008402	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
251221008403	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
251221008404	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221008405	FeS/SAM binding site; other site
251221008406	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
251221008407	Ligand Binding Site [chemical binding]; other site
251221008408	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
251221008409	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
251221008410	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
251221008411	cytochrome b subunit interaction site [polypeptide binding]; other site
251221008412	[2Fe-2S] cluster binding site [ion binding]; other site
251221008413	apocytochrome f; Reviewed; Region: PRK02693
251221008414	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
251221008415	Protein phosphatase 2C; Region: PP2C_2; pfam13672
251221008416	TPR repeat; Region: TPR_11; pfam13414
251221008417	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221008418	binding surface
251221008419	TPR motif; other site
251221008420	TPR repeat; Region: TPR_11; pfam13414
251221008421	Tetratricopeptide repeat; Region: TPR_16; pfam13432
251221008422	Tetratricopeptide repeat; Region: TPR_17; pfam13431
251221008423	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
251221008424	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
251221008425	active site
251221008426	PIN domain; Region: PIN_3; pfam13470
251221008427	MOSC domain; Region: MOSC; pfam03473
251221008428	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
251221008429	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
251221008430	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
251221008431	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
251221008432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221008433	S-adenosylmethionine binding site [chemical binding]; other site
251221008434	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
251221008435	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221008436	active site
251221008437	SnoaL-like domain; Region: SnoaL_2; pfam12680
251221008438	Protein of unknown function (DUF1016); Region: DUF1016; cl19557
251221008439	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
251221008440	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008441	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221008442	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008443	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008444	MAPEG family; Region: MAPEG; pfam01124
251221008445	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221008446	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221008447	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
251221008448	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
251221008449	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
251221008450	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
251221008451	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
251221008452	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
251221008453	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
251221008454	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
251221008455	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
251221008456	active sites [active]
251221008457	tetramer interface [polypeptide binding]; other site
251221008458	FAD binding domain; Region: FAD_binding_4; pfam01565
251221008459	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
251221008460	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
251221008461	Domain of unknown function (DUF4610); Region: DUF4610; pfam15384
251221008462	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
251221008463	FAD binding domain; Region: FAD_binding_4; pfam01565
251221008464	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
251221008465	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
251221008466	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
251221008467	Cysteine-rich domain; Region: CCG; pfam02754
251221008468	Cysteine-rich domain; Region: CCG; pfam02754
251221008469	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
251221008470	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
251221008471	TPP-binding site [chemical binding]; other site
251221008472	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
251221008473	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
251221008474	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221008475	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221008476	DNA binding residues [nucleotide binding]
251221008477	dimerization interface [polypeptide binding]; other site
251221008478	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
251221008479	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
251221008480	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008481	putative active site [active]
251221008482	AAA ATPase domain; Region: AAA_15; pfam13175
251221008483	AAA domain; Region: AAA_23; pfam13476
251221008484	Walker A/P-loop; other site
251221008485	hypothetical protein; Provisional; Region: PHA02940
251221008486	ATP binding site [chemical binding]; other site
251221008487	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
251221008488	ABC transporter signature motif; other site
251221008489	Walker B; other site
251221008490	D-loop; other site
251221008491	H-loop/switch region; other site
251221008492	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
251221008493	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
251221008494	quinone interaction residues [chemical binding]; other site
251221008495	active site
251221008496	catalytic residues [active]
251221008497	FMN binding site [chemical binding]; other site
251221008498	substrate binding site [chemical binding]; other site
251221008499	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
251221008500	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
251221008501	MOSC domain; Region: MOSC; pfam03473
251221008502	DNA gyrase subunit A; Validated; Region: PRK05560
251221008503	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
251221008504	CAP-like domain; other site
251221008505	active site
251221008506	primary dimer interface [polypeptide binding]; other site
251221008507	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221008508	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221008509	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221008510	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221008511	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221008512	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
251221008513	Helix-turn-helix domain; Region: HTH_28; pfam13518
251221008514	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
251221008515	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
251221008516	active site
251221008517	Substrate binding site; other site
251221008518	Mg++ binding site; other site
251221008519	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221008520	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
251221008521	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
251221008522	HemN C-terminal domain; Region: HemN_C; pfam06969
251221008523	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
251221008524	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
251221008525	putative active site [active]
251221008526	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
251221008527	active site
251221008528	catalytic residues [active]
251221008529	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
251221008530	PA/protease or protease-like domain interface [polypeptide binding]; other site
251221008531	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
251221008532	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
251221008533	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
251221008534	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221008535	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221008536	S-adenosylmethionine binding site [chemical binding]; other site
251221008537	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
251221008538	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
251221008539	active site
251221008540	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
251221008541	active site
251221008542	Fe binding site [ion binding]; other site
251221008543	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
251221008544	putative active site [active]
251221008545	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
251221008546	Beta-lactamase; Region: Beta-lactamase; pfam00144
251221008547	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
251221008548	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
251221008549	active site
251221008550	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
251221008551	ornithine carbamoyltransferase; Provisional; Region: PRK00779
251221008552	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
251221008553	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
251221008554	Tricorn protease C1 domain; Region: Tricorn_C1; pfam14684
251221008555	C-terminal peptidase (prc); Region: prc; TIGR00225
251221008556	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
251221008557	protein binding site [polypeptide binding]; other site
251221008558	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
251221008559	Catalytic dyad [active]
251221008560	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
251221008561	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221008562	N-terminal plug; other site
251221008563	ligand-binding site [chemical binding]; other site
251221008564	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
251221008565	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
251221008566	Walker A/P-loop; other site
251221008567	ATP binding site [chemical binding]; other site
251221008568	Q-loop/lid; other site
251221008569	ABC transporter signature motif; other site
251221008570	Walker B; other site
251221008571	D-loop; other site
251221008572	H-loop/switch region; other site
251221008573	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
251221008574	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
251221008575	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
251221008576	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
251221008577	Domain of unknown function (DUF3526); Region: DUF3526; pfam12040
251221008578	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
251221008579	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
251221008580	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
251221008581	active site residue [active]
251221008582	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
251221008583	FAD binding pocket [chemical binding]; other site
251221008584	conserved FAD binding motif [chemical binding]; other site
251221008585	phosphate binding motif [ion binding]; other site
251221008586	beta-alpha-beta structure motif; other site
251221008587	NAD binding pocket [chemical binding]; other site
251221008588	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
251221008589	putative active site [active]
251221008590	2TM domain; Region: 2TM; pfam13239
251221008591	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
251221008592	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
251221008593	HSP70 interaction site [polypeptide binding]; other site
251221008594	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
251221008595	substrate binding site [polypeptide binding]; other site
251221008596	dimer interface [polypeptide binding]; other site
251221008597	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
251221008598	hypothetical protein; Provisional; Region: PRK08912
251221008599	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
251221008600	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221008601	homodimer interface [polypeptide binding]; other site
251221008602	catalytic residue [active]
251221008603	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
251221008604	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008605	putative active site [active]
251221008606	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
251221008607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221008608	Walker A motif; other site
251221008609	ATP binding site [chemical binding]; other site
251221008610	Walker B motif; other site
251221008611	arginine finger; other site
251221008612	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
251221008613	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
251221008614	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
251221008615	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
251221008616	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
251221008617	NADP binding site [chemical binding]; other site
251221008618	active site
251221008619	putative substrate binding site [chemical binding]; other site
251221008620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221008621	active site
251221008622	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221008623	phosphorylation site [posttranslational modification]
251221008624	intermolecular recognition site; other site
251221008625	dimerization interface [polypeptide binding]; other site
251221008626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221008627	dimer interface [polypeptide binding]; other site
251221008628	phosphorylation site [posttranslational modification]
251221008629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221008630	ATP binding site [chemical binding]; other site
251221008631	Mg2+ binding site [ion binding]; other site
251221008632	G-X-G motif; other site
251221008633	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
251221008634	catalytic site [active]
251221008635	putative active site [active]
251221008636	putative substrate binding site [chemical binding]; other site
251221008637	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
251221008638	active site
251221008639	ATP binding site [chemical binding]; other site
251221008640	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
251221008641	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
251221008642	hinge; other site
251221008643	active site
251221008644	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
251221008645	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
251221008646	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
251221008647	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
251221008648	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
251221008649	dimer interface [polypeptide binding]; other site
251221008650	motif 1; other site
251221008651	active site
251221008652	motif 2; other site
251221008653	motif 3; other site
251221008654	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
251221008655	AMP binding site [chemical binding]; other site
251221008656	metal binding site [ion binding]; metal-binding site
251221008657	active site
251221008658	Putative restriction endonuclease; Region: Uma2; pfam05685
251221008659	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
251221008660	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
251221008661	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221008662	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
251221008663	Walker A motif; other site
251221008664	ATP binding site [chemical binding]; other site
251221008665	Walker B motif; other site
251221008666	TRAM domain; Region: TRAM; pfam01938
251221008667	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
251221008668	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221008669	S-adenosylmethionine binding site [chemical binding]; other site
251221008670	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
251221008671	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008672	putative active site [active]
251221008673	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221008674	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221008675	dimer interface [polypeptide binding]; other site
251221008676	phosphorylation site [posttranslational modification]
251221008677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221008678	ATP binding site [chemical binding]; other site
251221008679	Mg2+ binding site [ion binding]; other site
251221008680	G-X-G motif; other site
251221008681	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221008682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221008683	active site
251221008684	phosphorylation site [posttranslational modification]
251221008685	intermolecular recognition site; other site
251221008686	dimerization interface [polypeptide binding]; other site
251221008687	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221008688	DNA binding site [nucleotide binding]
251221008689	FtsH Extracellular; Region: FtsH_ext; pfam06480
251221008690	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
251221008691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221008692	Walker A motif; other site
251221008693	ATP binding site [chemical binding]; other site
251221008694	Walker B motif; other site
251221008695	arginine finger; other site
251221008696	Peptidase family M41; Region: Peptidase_M41; pfam01434
251221008697	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
251221008698	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221008699	Coenzyme A binding pocket [chemical binding]; other site
251221008700	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
251221008701	active site
251221008702	Zn binding site [ion binding]; other site
251221008703	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
251221008704	pheophytin binding site; other site
251221008705	chlorophyll binding site; other site
251221008706	quinone binding site; other site
251221008707	Fe binding site [ion binding]; other site
251221008708	acyl-ACP reductase; Provisional; Region: PRK14982
251221008709	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
251221008710	NAD(P) binding pocket [chemical binding]; other site
251221008711	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
251221008712	dinuclear metal binding motif [ion binding]; other site
251221008713	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
251221008714	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
251221008715	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
251221008716	RNase E interface [polypeptide binding]; other site
251221008717	trimer interface [polypeptide binding]; other site
251221008718	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
251221008719	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
251221008720	RNase E interface [polypeptide binding]; other site
251221008721	trimer interface [polypeptide binding]; other site
251221008722	active site
251221008723	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
251221008724	putative nucleic acid binding region [nucleotide binding]; other site
251221008725	G-X-X-G motif; other site
251221008726	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
251221008727	RNA binding site [nucleotide binding]; other site
251221008728	domain interface; other site
251221008729	TM2 domain; Region: TM2; pfam05154
251221008730	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
251221008731	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
251221008732	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
251221008733	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
251221008734	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
251221008735	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
251221008736	phosphopeptide binding site; other site
251221008737	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
251221008738	catalytic core [active]
251221008739	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
251221008740	catalytic residues [active]
251221008741	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
251221008742	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
251221008743	dimer interface [polypeptide binding]; other site
251221008744	decamer (pentamer of dimers) interface [polypeptide binding]; other site
251221008745	catalytic triad [active]
251221008746	peroxidatic and resolving cysteines [active]
251221008747	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
251221008748	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
251221008749	G1 box; other site
251221008750	putative GEF interaction site [polypeptide binding]; other site
251221008751	GTP/Mg2+ binding site [chemical binding]; other site
251221008752	Switch I region; other site
251221008753	G2 box; other site
251221008754	G3 box; other site
251221008755	Switch II region; other site
251221008756	G4 box; other site
251221008757	G5 box; other site
251221008758	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
251221008759	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
251221008760	putative active site [active]
251221008761	putative catalytic triad [active]
251221008762	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
251221008763	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
251221008764	catalytic residues [active]
251221008765	Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562
251221008766	putative active site [active]
251221008767	putative catalytic triad [active]
251221008768	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
251221008769	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
251221008770	catalytic residues [active]
251221008771	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
251221008772	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
251221008773	acyl-activating enzyme (AAE) consensus motif; other site
251221008774	active site
251221008775	AMP binding site [chemical binding]; other site
251221008776	CoA binding site [chemical binding]; other site
251221008777	Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518
251221008778	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221008779	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
251221008780	putative ADP-binding pocket [chemical binding]; other site
251221008781	N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742
251221008782	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
251221008783	Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168
251221008784	TPR repeat; Region: TPR_11; pfam13414
251221008785	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221008786	binding surface
251221008787	TPR motif; other site
251221008788	TPR repeat; Region: TPR_11; pfam13414
251221008789	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
251221008790	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
251221008791	Kelch motif; Region: Kelch_1; pfam01344
251221008792	Kelch domain; Region: Kelch; smart00612
251221008793	Kelch domain; Region: Kelch; smart00612
251221008794	Kelch domain; Region: Kelch; smart00612
251221008795	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
251221008796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221008797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221008798	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
251221008799	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221008800	active site
251221008801	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
251221008802	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
251221008803	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
251221008804	Phosphotransferase enzyme family; Region: APH; pfam01636
251221008805	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
251221008806	active site
251221008807	substrate binding site [chemical binding]; other site
251221008808	ATP binding site [chemical binding]; other site
251221008809	Low molecular weight phosphatase family; Region: LMWPc; cd00115
251221008810	active site
251221008811	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
251221008812	CAAX protease self-immunity; Region: Abi; pfam02517
251221008813	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
251221008814	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
251221008815	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221008816	motif II; other site
251221008817	hypothetical protein; Provisional; Region: PRK13683
251221008818	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
251221008819	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
251221008820	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
251221008821	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
251221008822	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
251221008823	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
251221008824	putative active site [active]
251221008825	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
251221008826	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
251221008827	RNA binding surface [nucleotide binding]; other site
251221008828	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
251221008829	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
251221008830	catalytic loop [active]
251221008831	iron binding site [ion binding]; other site
251221008832	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
251221008833	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
251221008834	homotetramer interface [polypeptide binding]; other site
251221008835	ligand binding site [chemical binding]; other site
251221008836	catalytic site [active]
251221008837	NAD binding site [chemical binding]; other site
251221008838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
251221008839	Fic family protein [Function unknown]; Region: COG3177
251221008840	Fic/DOC family; Region: Fic; pfam02661
251221008841	hypothetical protein; Provisional; Region: PRK12705
251221008842	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008843	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221008844	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008845	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221008846	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
251221008847	HD domain; Region: HD_5; pfam13487
251221008848	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
251221008849	active site
251221008850	metal binding site [ion binding]; metal-binding site
251221008851	MarC family integral membrane protein; Region: MarC; pfam01914
251221008852	DNA topoisomerase I; Validated; Region: PRK05582
251221008853	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
251221008854	active site
251221008855	interdomain interaction site; other site
251221008856	putative metal-binding site [ion binding]; other site
251221008857	nucleotide binding site [chemical binding]; other site
251221008858	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
251221008859	domain I; other site
251221008860	DNA binding groove [nucleotide binding]
251221008861	phosphate binding site [ion binding]; other site
251221008862	domain II; other site
251221008863	domain III; other site
251221008864	nucleotide binding site [chemical binding]; other site
251221008865	catalytic site [active]
251221008866	domain IV; other site
251221008867	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
251221008868	CHY zinc finger; Region: zf-CHY; cl19861
251221008869	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
251221008870	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
251221008871	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
251221008872	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221008873	putative active site [active]
251221008874	Phosphoesterase family; Region: Phosphoesterase; pfam04185
251221008875	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
251221008876	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
251221008877	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
251221008878	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
251221008879	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
251221008880	L11 interface [polypeptide binding]; other site
251221008881	putative EF-Tu interaction site [polypeptide binding]; other site
251221008882	putative EF-G interaction site [polypeptide binding]; other site
251221008883	Kelch domain; Region: Kelch; smart00612
251221008884	Kelch motif; Region: Kelch_1; pfam01344
251221008885	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
251221008886	Kelch motif; Region: Kelch_1; pfam01344
251221008887	Kelch domain; Region: Kelch; smart00612
251221008888	Kelch domain; Region: Kelch; smart00612
251221008889	Kelch domain; Region: Kelch; smart00612
251221008890	Kelch motif; Region: Kelch_1; pfam01344
251221008891	Kelch motif; Region: Kelch_6; pfam13964
251221008892	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221008893	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
251221008894	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
251221008895	GTP-binding protein Der; Reviewed; Region: PRK00093
251221008896	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
251221008897	G1 box; other site
251221008898	GTP/Mg2+ binding site [chemical binding]; other site
251221008899	Switch I region; other site
251221008900	G2 box; other site
251221008901	Switch II region; other site
251221008902	G3 box; other site
251221008903	G4 box; other site
251221008904	G5 box; other site
251221008905	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
251221008906	G1 box; other site
251221008907	GTP/Mg2+ binding site [chemical binding]; other site
251221008908	Switch I region; other site
251221008909	G2 box; other site
251221008910	G3 box; other site
251221008911	Switch II region; other site
251221008912	G4 box; other site
251221008913	G5 box; other site
251221008914	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
251221008915	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
251221008916	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
251221008917	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
251221008918	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
251221008919	domain interfaces; other site
251221008920	active site
251221008921	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
251221008922	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
251221008923	Catalytic site [active]
251221008924	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
251221008925	Phycobilisome protein; Region: Phycobilisome; cl08227
251221008926	Phycobilisome protein; Region: Phycobilisome; cl08227
251221008927	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
251221008928	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
251221008929	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221008930	Coenzyme A binding pocket [chemical binding]; other site
251221008931	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
251221008932	Helix-turn-helix domain; Region: HTH_38; pfam13936
251221008933	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
251221008934	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
251221008935	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
251221008936	putative active site [active]
251221008937	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
251221008938	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
251221008939	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
251221008940	MarC family integral membrane protein; Region: MarC; cl00919
251221008941	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
251221008942	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
251221008943	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221008944	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
251221008945	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
251221008946	FG-GAP repeat; Region: FG-GAP; pfam01839
251221008947	DNA polymerase III subunit beta; Validated; Region: PRK05643
251221008948	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
251221008949	putative DNA binding surface [nucleotide binding]; other site
251221008950	dimer interface [polypeptide binding]; other site
251221008951	beta-clamp/clamp loader binding surface; other site
251221008952	beta-clamp/translesion DNA polymerase binding surface; other site
251221008953	GTP-binding protein YchF; Reviewed; Region: PRK09601
251221008954	YchF GTPase; Region: YchF; cd01900
251221008955	G1 box; other site
251221008956	GTP/Mg2+ binding site [chemical binding]; other site
251221008957	Switch I region; other site
251221008958	G2 box; other site
251221008959	Switch II region; other site
251221008960	G3 box; other site
251221008961	G4 box; other site
251221008962	G5 box; other site
251221008963	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
251221008964	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
251221008965	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
251221008966	NADP binding site [chemical binding]; other site
251221008967	active site
251221008968	putative substrate binding site [chemical binding]; other site
251221008969	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
251221008970	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
251221008971	NAD binding site [chemical binding]; other site
251221008972	substrate binding site [chemical binding]; other site
251221008973	homodimer interface [polypeptide binding]; other site
251221008974	active site
251221008975	Bacterial sugar transferase; Region: Bac_transf; pfam02397
251221008976	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
251221008977	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
251221008978	substrate binding site; other site
251221008979	metal-binding site
251221008980	Oligomer interface; other site
251221008981	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221008982	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
251221008983	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
251221008984	SLBB domain; Region: SLBB; pfam10531
251221008985	TPR repeat; Region: TPR_11; pfam13414
251221008986	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221008987	binding surface
251221008988	TPR motif; other site
251221008989	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221008990	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221008991	binding surface
251221008992	TPR motif; other site
251221008993	TPR repeat; Region: TPR_11; pfam13414
251221008994	TPR repeat; Region: TPR_11; pfam13414
251221008995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221008996	TPR motif; other site
251221008997	binding surface
251221008998	TPR repeat; Region: TPR_11; pfam13414
251221008999	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
251221009000	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
251221009001	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
251221009002	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
251221009003	Protein of unknown function (DUF3140); Region: DUF3140; pfam11338
251221009004	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
251221009005	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
251221009006	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
251221009007	Putative restriction endonuclease; Region: Uma2; pfam05685
251221009008	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
251221009009	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
251221009010	P-loop; other site
251221009011	Magnesium ion binding site [ion binding]; other site
251221009012	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221009013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
251221009014	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
251221009015	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
251221009016	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
251221009017	Protein of unknown function, DUF393; Region: DUF393; pfam04134
251221009018	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221009019	putative active site [active]
251221009020	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
251221009021	active site
251221009022	Ycf39; Provisional; Region: ycf39; CHL00194
251221009023	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
251221009024	NAD(P) binding site [chemical binding]; other site
251221009025	putative active site [active]
251221009026	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
251221009027	Ycf46; Provisional; Region: ycf46; CHL00195
251221009028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221009029	Walker A motif; other site
251221009030	ATP binding site [chemical binding]; other site
251221009031	Walker B motif; other site
251221009032	arginine finger; other site
251221009033	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
251221009034	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
251221009035	dimer interface [polypeptide binding]; other site
251221009036	ADP-ribose binding site [chemical binding]; other site
251221009037	active site
251221009038	nudix motif; other site
251221009039	metal binding site [ion binding]; metal-binding site
251221009040	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
251221009041	OstA-like protein; Region: OstA; cl00844
251221009042	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
251221009043	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
251221009044	Walker A/P-loop; other site
251221009045	ATP binding site [chemical binding]; other site
251221009046	Q-loop/lid; other site
251221009047	ABC transporter signature motif; other site
251221009048	Walker B; other site
251221009049	D-loop; other site
251221009050	H-loop/switch region; other site
251221009051	hypothetical protein; Provisional; Region: PRK11281
251221009052	Homeodomain-like domain; Region: HTH_23; pfam13384
251221009053	Winged helix-turn helix; Region: HTH_29; pfam13551
251221009054	Homeodomain-like domain; Region: HTH_32; pfam13565
251221009055	DDE superfamily endonuclease; Region: DDE_3; pfam13358
251221009056	Transposase [DNA replication, recombination, and repair]; Region: COG5421
251221009057	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
251221009058	Protein of unknown function (DUF541); Region: SIMPL; cl01077
251221009059	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
251221009060	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221009061	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
251221009062	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
251221009063	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
251221009064	putative active site [active]
251221009065	catalytic site [active]
251221009066	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
251221009067	putative active site [active]
251221009068	catalytic site [active]
251221009069	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
251221009070	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
251221009071	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
251221009072	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
251221009073	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
251221009074	shikimate binding site; other site
251221009075	NAD(P) binding site [chemical binding]; other site
251221009076	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
251221009077	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
251221009078	PYR/PP interface [polypeptide binding]; other site
251221009079	dimer interface [polypeptide binding]; other site
251221009080	TPP binding site [chemical binding]; other site
251221009081	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
251221009082	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
251221009083	TPP-binding site [chemical binding]; other site
251221009084	dimer interface [polypeptide binding]; other site
251221009085	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
251221009086	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
251221009087	GDP-binding site [chemical binding]; other site
251221009088	ACT binding site; other site
251221009089	IMP binding site; other site
251221009090	Bacitracin resistance protein BacA; Region: BacA; pfam02673
251221009091	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
251221009092	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
251221009093	periplasmic protein; Provisional; Region: PRK10568
251221009094	BON domain; Region: BON; pfam04972
251221009095	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221009096	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
251221009097	ligand binding site [chemical binding]; other site
251221009098	flexible hinge region; other site
251221009099	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
251221009100	putative switch regulator; other site
251221009101	non-specific DNA interactions [nucleotide binding]; other site
251221009102	DNA binding site [nucleotide binding]
251221009103	sequence specific DNA binding site [nucleotide binding]; other site
251221009104	putative cAMP binding site [chemical binding]; other site
251221009105	photosystem I iron-sulfur protein PsaC; Region: PS_I_psaC; TIGR03048
251221009106	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
251221009107	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
251221009108	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
251221009109	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
251221009110	The cupredoxin domain 1 of a two-domain laccase related to nitrite reductase; Region: CuRO_1_2DMCO_NIR_like; cd11024
251221009111	Domain 2 interface [polypeptide binding]; other site
251221009112	Type 1 (T1) Cu binding site [ion binding]; other site
251221009113	trimer interface [polypeptide binding]; other site
251221009114	trinuclear Cu binding site [ion binding]; other site
251221009115	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
251221009116	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221009117	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221009118	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221009119	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
251221009120	putative switch regulator; other site
251221009121	non-specific DNA interactions [nucleotide binding]; other site
251221009122	DNA binding site [nucleotide binding]
251221009123	sequence specific DNA binding site [nucleotide binding]; other site
251221009124	putative cAMP binding site [chemical binding]; other site
251221009125	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
251221009126	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
251221009127	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
251221009128	thiamine monophosphate kinase; Provisional; Region: PRK05731
251221009129	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
251221009130	ATP binding site [chemical binding]; other site
251221009131	dimerization interface [polypeptide binding]; other site
251221009132	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
251221009133	Fe-S cluster binding site [ion binding]; other site
251221009134	substrate binding site [chemical binding]; other site
251221009135	catalytic site [active]
251221009136	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
251221009137	active site
251221009138	putative DNA-binding cleft [nucleotide binding]; other site
251221009139	dimer interface [polypeptide binding]; other site
251221009140	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
251221009141	metal binding site 2 [ion binding]; metal-binding site
251221009142	putative DNA binding helix; other site
251221009143	metal binding site 1 [ion binding]; metal-binding site
251221009144	dimer interface [polypeptide binding]; other site
251221009145	structural Zn2+ binding site [ion binding]; other site
251221009146	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
251221009147	Cupin domain; Region: Cupin_2; cl17218
251221009148	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221009149	putative active site [active]
251221009150	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
251221009151	active site
251221009152	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
251221009153	ABC-ATPase subunit  interface; other site
251221009154	dimer interface [polypeptide binding]; other site
251221009155	putative PBP binding regions; other site
251221009156	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
251221009157	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
251221009158	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
251221009159	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
251221009160	intersubunit interface [polypeptide binding]; other site
251221009161	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
251221009162	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
251221009163	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
251221009164	ABC-ATPase subunit  interface; other site
251221009165	dimer interface [polypeptide binding]; other site
251221009166	putative PBP binding regions; other site
251221009167	PAS fold; Region: PAS_4; pfam08448
251221009168	4-alpha-glucanotransferase; Provisional; Region: PRK14508
251221009169	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
251221009170	amidase catalytic site [active]
251221009171	Zn binding residues [ion binding]; other site
251221009172	substrate binding site [chemical binding]; other site
251221009173	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
251221009174	putative active site [active]
251221009175	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
251221009176	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
251221009177	Walker A/P-loop; other site
251221009178	ATP binding site [chemical binding]; other site
251221009179	Q-loop/lid; other site
251221009180	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
251221009181	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
251221009182	ABC transporter signature motif; other site
251221009183	Walker B; other site
251221009184	D-loop; other site
251221009185	H-loop/switch region; other site
251221009186	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
251221009187	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
251221009188	domain interfaces; other site
251221009189	active site
251221009190	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
251221009191	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
251221009192	NAD binding site [chemical binding]; other site
251221009193	dimer interface [polypeptide binding]; other site
251221009194	substrate binding site [chemical binding]; other site
251221009195	tetramer (dimer of dimers) interface [polypeptide binding]; other site
251221009196	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
251221009197	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
251221009198	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
251221009199	Predicted membrane protein [Function unknown]; Region: COG4244
251221009200	High-affinity nickel-transport protein; Region: NicO; cl00964
251221009201	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
251221009202	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
251221009203	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221009204	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221009205	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
251221009206	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
251221009207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221009208	S-adenosylmethionine binding site [chemical binding]; other site
251221009209	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
251221009210	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
251221009211	Ligand binding site; other site
251221009212	Putative Catalytic site; other site
251221009213	DXD motif; other site
251221009214	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
251221009215	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
251221009216	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
251221009217	Walker A/P-loop; other site
251221009218	ATP binding site [chemical binding]; other site
251221009219	Q-loop/lid; other site
251221009220	ABC transporter signature motif; other site
251221009221	Walker B; other site
251221009222	D-loop; other site
251221009223	H-loop/switch region; other site
251221009224	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
251221009225	Uncharacterized conserved protein [Function unknown]; Region: COG3937
251221009226	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
251221009227	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
251221009228	putative GSH binding site [chemical binding]; other site
251221009229	catalytic residues [active]
251221009230	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
251221009231	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
251221009232	active site
251221009233	Substrate binding site; other site
251221009234	Mg++ binding site; other site
251221009235	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221009236	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
251221009237	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
251221009238	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
251221009239	putative active site [active]
251221009240	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221009241	putative active site [active]
251221009242	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
251221009243	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
251221009244	starch-binding site 2 [chemical binding]; other site
251221009245	starch-binding site 1 [chemical binding]; other site
251221009246	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
251221009247	active site
251221009248	catalytic triad [active]
251221009249	oxyanion hole [active]
251221009250	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
251221009251	Transposase [DNA replication, recombination, and repair]; Region: COG5421
251221009252	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
251221009253	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
251221009254	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
251221009255	ParB-like nuclease domain; Region: ParBc; pfam02195
251221009256	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
251221009257	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
251221009258	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; cl10048
251221009259	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
251221009260	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
251221009261	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221009262	S-adenosylmethionine binding site [chemical binding]; other site
251221009263	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
251221009264	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
251221009265	dimer interface [polypeptide binding]; other site
251221009266	putative anticodon binding site; other site
251221009267	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
251221009268	motif 1; other site
251221009269	active site
251221009270	motif 2; other site
251221009271	motif 3; other site
251221009272	EamA-like transporter family; Region: EamA; pfam00892
251221009273	EamA-like transporter family; Region: EamA; pfam00892
251221009274	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
251221009275	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221009276	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
251221009277	dimerization interface [polypeptide binding]; other site
251221009278	substrate binding pocket [chemical binding]; other site
251221009279	Laminin Domain II; Region: Laminin_II; pfam06009
251221009280	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
251221009281	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221009282	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
251221009283	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
251221009284	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
251221009285	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
251221009286	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
251221009287	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
251221009288	Ligand binding site [chemical binding]; other site
251221009289	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
251221009290	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
251221009291	Domain of unknown function (DUF4433); Region: DUF4433; pfam14487
251221009292	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
251221009293	ADP-ribose binding site [chemical binding]; other site
251221009294	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
251221009295	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
251221009296	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
251221009297	putative dimer interface [polypeptide binding]; other site
251221009298	N-terminal domain interface [polypeptide binding]; other site
251221009299	putative substrate binding pocket (H-site) [chemical binding]; other site
251221009300	Kelch domain; Region: Kelch; smart00612
251221009301	Kelch domain; Region: Kelch; smart00612
251221009302	Kelch motif; Region: Kelch_1; pfam01344
251221009303	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
251221009304	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
251221009305	putative active site [active]
251221009306	catalytic residue [active]
251221009307	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
251221009308	trimer interface [polypeptide binding]; other site
251221009309	dimer interface [polypeptide binding]; other site
251221009310	putative active site [active]
251221009311	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
251221009312	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
251221009313	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
251221009314	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
251221009315	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
251221009316	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221009317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
251221009318	Coenzyme A binding pocket [chemical binding]; other site
251221009319	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
251221009320	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
251221009321	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221009322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221009323	S-adenosylmethionine binding site [chemical binding]; other site
251221009324	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
251221009325	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
251221009326	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
251221009327	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
251221009328	catalytic triad [active]
251221009329	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009330	TPR motif; other site
251221009331	binding surface
251221009332	HEAT repeats; Region: HEAT_2; pfam13646
251221009333	HEAT repeats; Region: HEAT_2; pfam13646
251221009334	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221009335	putative active site [active]
251221009336	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
251221009337	Tetramer interface [polypeptide binding]; other site
251221009338	active site
251221009339	FMN-binding site [chemical binding]; other site
251221009340	Cupin domain; Region: Cupin_2; cl17218
251221009341	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221009342	active site
251221009343	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221009344	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221009345	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
251221009346	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
251221009347	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
251221009348	active site
251221009349	metal binding site [ion binding]; metal-binding site
251221009350	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
251221009351	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
251221009352	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221009353	Coenzyme A binding pocket [chemical binding]; other site
251221009354	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
251221009355	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
251221009356	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
251221009357	RDD family; Region: RDD; pfam06271
251221009358	TonB C terminal; Region: TonB_2; pfam13103
251221009359	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
251221009360	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
251221009361	DNA binding site [nucleotide binding]
251221009362	catalytic residue [active]
251221009363	H2TH interface [polypeptide binding]; other site
251221009364	putative catalytic residues [active]
251221009365	turnover-facilitating residue; other site
251221009366	intercalation triad [nucleotide binding]; other site
251221009367	8OG recognition residue [nucleotide binding]; other site
251221009368	putative reading head residues; other site
251221009369	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
251221009370	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
251221009371	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
251221009372	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221009373	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221009374	putative active site [active]
251221009375	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221009376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221009377	Coenzyme A binding pocket [chemical binding]; other site
251221009378	hypothetical protein; Validated; Region: PRK07411
251221009379	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
251221009380	ATP binding site [chemical binding]; other site
251221009381	substrate interface [chemical binding]; other site
251221009382	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
251221009383	active site residue [active]
251221009384	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
251221009385	MoaE interaction surface [polypeptide binding]; other site
251221009386	MoeB interaction surface [polypeptide binding]; other site
251221009387	thiocarboxylated glycine; other site
251221009388	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
251221009389	MPN+ (JAMM) motif; other site
251221009390	Zinc-binding site [ion binding]; other site
251221009391	recombinase A; Provisional; Region: recA; PRK09354
251221009392	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
251221009393	hexamer interface [polypeptide binding]; other site
251221009394	Walker A motif; other site
251221009395	ATP binding site [chemical binding]; other site
251221009396	Walker B motif; other site
251221009397	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
251221009398	substrate binding site [chemical binding]; other site
251221009399	ligand binding site [chemical binding]; other site
251221009400	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
251221009401	substrate binding site [chemical binding]; other site
251221009402	Predicted membrane protein [Function unknown]; Region: COG4270
251221009403	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221009404	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
251221009405	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
251221009406	Walker A/P-loop; other site
251221009407	ATP binding site [chemical binding]; other site
251221009408	Q-loop/lid; other site
251221009409	ABC transporter signature motif; other site
251221009410	Walker B; other site
251221009411	D-loop; other site
251221009412	H-loop/switch region; other site
251221009413	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
251221009414	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
251221009415	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
251221009416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221009417	homodimer interface [polypeptide binding]; other site
251221009418	catalytic residue [active]
251221009419	histone-like DNA-binding protein HU; Region: HU; cd13831
251221009420	dimer interface [polypeptide binding]; other site
251221009421	DNA binding site [nucleotide binding]
251221009422	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
251221009423	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
251221009424	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
251221009425	AsmA family; Region: AsmA; pfam05170
251221009426	Protein of unknown function; Region: DUF3971; pfam13116
251221009427	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
251221009428	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
251221009429	putative active site [active]
251221009430	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
251221009431	dimerization interface [polypeptide binding]; other site
251221009432	putative DNA binding site [nucleotide binding]; other site
251221009433	putative Zn2+ binding site [ion binding]; other site
251221009434	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
251221009435	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
251221009436	Sulfatase; Region: Sulfatase; pfam00884
251221009437	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221009438	PAS fold; Region: PAS_3; pfam08447
251221009439	putative active site [active]
251221009440	heme pocket [chemical binding]; other site
251221009441	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
251221009442	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221009443	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221009444	dimer interface [polypeptide binding]; other site
251221009445	phosphorylation site [posttranslational modification]
251221009446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221009447	ATP binding site [chemical binding]; other site
251221009448	Mg2+ binding site [ion binding]; other site
251221009449	G-X-G motif; other site
251221009450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221009451	active site
251221009452	phosphorylation site [posttranslational modification]
251221009453	intermolecular recognition site; other site
251221009454	dimerization interface [polypeptide binding]; other site
251221009455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221009456	active site
251221009457	phosphorylation site [posttranslational modification]
251221009458	intermolecular recognition site; other site
251221009459	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
251221009460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221009461	putative active site [active]
251221009462	heme pocket [chemical binding]; other site
251221009463	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221009464	dimer interface [polypeptide binding]; other site
251221009465	phosphorylation site [posttranslational modification]
251221009466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221009467	ATP binding site [chemical binding]; other site
251221009468	Mg2+ binding site [ion binding]; other site
251221009469	G-X-G motif; other site
251221009470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221009471	active site
251221009472	phosphorylation site [posttranslational modification]
251221009473	intermolecular recognition site; other site
251221009474	dimerization interface [polypeptide binding]; other site
251221009475	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
251221009476	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
251221009477	[2Fe-2S] cluster binding site [ion binding]; other site
251221009478	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
251221009479	putative alpha subunit interface [polypeptide binding]; other site
251221009480	putative active site [active]
251221009481	putative substrate binding site [chemical binding]; other site
251221009482	Fe binding site [ion binding]; other site
251221009483	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
251221009484	FAD binding domain; Region: FAD_binding_4; pfam01565
251221009485	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
251221009486	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
251221009487	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
251221009488	Cysteine-rich domain; Region: CCG; pfam02754
251221009489	photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200
251221009490	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
251221009491	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
251221009492	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
251221009493	ligand binding site [chemical binding]; other site
251221009494	superantigen-like protein; Reviewed; Region: PRK13335
251221009495	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
251221009496	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
251221009497	DNA binding residues [nucleotide binding]
251221009498	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
251221009499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221009500	Walker A/P-loop; other site
251221009501	ATP binding site [chemical binding]; other site
251221009502	Q-loop/lid; other site
251221009503	ABC transporter signature motif; other site
251221009504	Walker B; other site
251221009505	D-loop; other site
251221009506	H-loop/switch region; other site
251221009507	ABC-2 type transporter; Region: ABC2_membrane; cl17235
251221009508	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
251221009509	DNA binding residues [nucleotide binding]
251221009510	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
251221009511	drug binding residues [chemical binding]; other site
251221009512	dimer interface [polypeptide binding]; other site
251221009513	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
251221009514	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221009515	GTPase RsgA; Reviewed; Region: PRK01889
251221009516	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
251221009517	RNA binding site [nucleotide binding]; other site
251221009518	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
251221009519	GTPase/Zn-binding domain interface [polypeptide binding]; other site
251221009520	GTP/Mg2+ binding site [chemical binding]; other site
251221009521	G4 box; other site
251221009522	G5 box; other site
251221009523	G1 box; other site
251221009524	Switch I region; other site
251221009525	G2 box; other site
251221009526	G3 box; other site
251221009527	Switch II region; other site
251221009528	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221009529	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221009530	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221009531	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221009532	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221009533	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221009534	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
251221009535	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
251221009536	active site
251221009537	metal binding site [ion binding]; metal-binding site
251221009538	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
251221009539	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
251221009540	putative C-terminal domain interface [polypeptide binding]; other site
251221009541	putative GSH binding site (G-site) [chemical binding]; other site
251221009542	putative dimer interface [polypeptide binding]; other site
251221009543	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
251221009544	putative N-terminal domain interface [polypeptide binding]; other site
251221009545	putative dimer interface [polypeptide binding]; other site
251221009546	putative substrate binding pocket (H-site) [chemical binding]; other site
251221009547	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
251221009548	Na binding site [ion binding]; other site
251221009549	ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283
251221009550	nad+ binding pocket [chemical binding]; other site
251221009551	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
251221009552	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
251221009553	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
251221009554	metal ion-dependent adhesion site (MIDAS); other site
251221009555	Transcriptional regulator PadR-like family; Region: PadR; cl17335
251221009556	TrkA-C domain; Region: TrkA_C; pfam02080
251221009557	TrkA-C domain; Region: TrkA_C; pfam02080
251221009558	TrkA-C domain; Region: TrkA_C; pfam02080
251221009559	TrkA-C domain; Region: TrkA_C; pfam02080
251221009560	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221009561	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
251221009562	active site
251221009563	catalytic tetrad [active]
251221009564	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
251221009565	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
251221009566	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
251221009567	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221009568	putative active site [active]
251221009569	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
251221009570	transketolase; Reviewed; Region: PRK05899
251221009571	TPP-binding site [chemical binding]; other site
251221009572	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
251221009573	PYR/PP interface [polypeptide binding]; other site
251221009574	dimer interface [polypeptide binding]; other site
251221009575	TPP binding site [chemical binding]; other site
251221009576	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
251221009577	hypothetical protein; Reviewed; Region: PRK00024
251221009578	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
251221009579	MPN+ (JAMM) motif; other site
251221009580	Zinc-binding site [ion binding]; other site
251221009581	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
251221009582	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
251221009583	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
251221009584	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
251221009585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221009586	homodimer interface [polypeptide binding]; other site
251221009587	catalytic residue [active]
251221009588	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
251221009589	NADPH bind site [chemical binding]; other site
251221009590	putative FMN binding site [chemical binding]; other site
251221009591	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
251221009592	putative FMN binding site [chemical binding]; other site
251221009593	NADPH bind site [chemical binding]; other site
251221009594	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
251221009595	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221009596	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
251221009597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221009598	Walker A/P-loop; other site
251221009599	ATP binding site [chemical binding]; other site
251221009600	Q-loop/lid; other site
251221009601	ABC transporter signature motif; other site
251221009602	Walker B; other site
251221009603	D-loop; other site
251221009604	H-loop/switch region; other site
251221009605	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
251221009606	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
251221009607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
251221009608	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221009609	Coenzyme A binding pocket [chemical binding]; other site
251221009610	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
251221009611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221009612	S-adenosylmethionine binding site [chemical binding]; other site
251221009613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221009614	S-adenosylmethionine binding site [chemical binding]; other site
251221009615	Transcriptional regulator [Transcription]; Region: LytR; COG1316
251221009616	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
251221009617	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
251221009618	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
251221009619	active site
251221009620	Substrate binding site; other site
251221009621	Mg++ binding site; other site
251221009622	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
251221009623	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
251221009624	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
251221009625	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
251221009626	active site
251221009627	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
251221009628	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
251221009629	NAD(P) binding site [chemical binding]; other site
251221009630	putative active site [active]
251221009631	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
251221009632	Ferritin-like domain; Region: Ferritin; pfam00210
251221009633	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
251221009634	dimerization interface [polypeptide binding]; other site
251221009635	DPS ferroxidase diiron center [ion binding]; other site
251221009636	ion pore; other site
251221009637	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
251221009638	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
251221009639	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221009640	catalytic residue [active]
251221009641	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
251221009642	Sm and related proteins; Region: Sm_like; cl00259
251221009643	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
251221009644	putative oligomer interface [polypeptide binding]; other site
251221009645	putative RNA binding site [nucleotide binding]; other site
251221009646	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
251221009647	NusA N-terminal domain; Region: NusA_N; pfam08529
251221009648	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
251221009649	RNA binding site [nucleotide binding]; other site
251221009650	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
251221009651	G-X-X-G motif; other site
251221009652	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
251221009653	G-X-X-G motif; other site
251221009654	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
251221009655	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
251221009656	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
251221009657	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
251221009658	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
251221009659	pyruvate kinase; Provisional; Region: PRK06354
251221009660	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
251221009661	domain interfaces; other site
251221009662	active site
251221009663	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700
251221009664	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
251221009665	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
251221009666	hypothetical protein; Validated; Region: PRK00153
251221009667	recombination protein RecR; Reviewed; Region: recR; PRK00076
251221009668	RecR protein; Region: RecR; pfam02132
251221009669	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
251221009670	putative active site [active]
251221009671	putative metal-binding site [ion binding]; other site
251221009672	tetramer interface [polypeptide binding]; other site
251221009673	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
251221009674	homotrimer interaction site [polypeptide binding]; other site
251221009675	putative active site [active]
251221009676	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221009677	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221009678	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221009679	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221009680	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221009681	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
251221009682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221009683	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
251221009684	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
251221009685	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
251221009686	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
251221009687	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
251221009688	NAD(P) binding site [chemical binding]; other site
251221009689	homotetramer interface [polypeptide binding]; other site
251221009690	homodimer interface [polypeptide binding]; other site
251221009691	active site
251221009692	Beta-lactamase; Region: Beta-lactamase; pfam00144
251221009693	AAA domain; Region: AAA_26; pfam13500
251221009694	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
251221009695	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
251221009696	trimer interface [polypeptide binding]; other site
251221009697	active site
251221009698	cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414
251221009699	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
251221009700	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
251221009701	HSP70 interaction site [polypeptide binding]; other site
251221009702	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
251221009703	Sulfotransferase family; Region: Sulfotransfer_2; cl19526
251221009704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221009705	S-adenosylmethionine binding site [chemical binding]; other site
251221009706	Sulfotransferase family; Region: Sulfotransfer_2; cl19526
251221009707	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
251221009708	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
251221009709	active site
251221009710	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
251221009711	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221009712	active site
251221009713	putative lipid kinase; Reviewed; Region: PRK00861
251221009714	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
251221009715	Protein of unknown function DUF86; Region: DUF86; cl01031
251221009716	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
251221009717	active site
251221009718	NTP binding site [chemical binding]; other site
251221009719	metal binding triad [ion binding]; metal-binding site
251221009720	antibiotic binding site [chemical binding]; other site
251221009721	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
251221009722	lipoyl synthase; Provisional; Region: PRK12928
251221009723	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221009724	FeS/SAM binding site; other site
251221009725	Predicted transcriptional regulator [Transcription]; Region: COG3905
251221009726	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
251221009727	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
251221009728	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
251221009729	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
251221009730	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
251221009731	lipoyl attachment site [posttranslational modification]; other site
251221009732	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
251221009733	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
251221009734	Protein of unknown function DUF45; Region: DUF45; pfam01863
251221009735	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
251221009736	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221009737	FeS/SAM binding site; other site
251221009738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011
251221009739	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
251221009740	UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
251221009741	putative active site [active]
251221009742	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
251221009743	intersubunit interface [polypeptide binding]; other site
251221009744	active site
251221009745	catalytic residue [active]
251221009746	Predicted integral membrane protein [Function unknown]; Region: COG0762
251221009747	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
251221009748	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
251221009749	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
251221009750	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
251221009751	protein binding site [polypeptide binding]; other site
251221009752	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009753	TPR motif; other site
251221009754	binding surface
251221009755	TPR repeat; Region: TPR_11; pfam13414
251221009756	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009757	binding surface
251221009758	TPR motif; other site
251221009759	TPR repeat; Region: TPR_11; pfam13414
251221009760	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009761	TPR repeat; Region: TPR_11; pfam13414
251221009762	binding surface
251221009763	TPR motif; other site
251221009764	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009765	binding surface
251221009766	TPR motif; other site
251221009767	TPR repeat; Region: TPR_11; pfam13414
251221009768	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
251221009769	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
251221009770	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
251221009771	catalytic site [active]
251221009772	subunit interface [polypeptide binding]; other site
251221009773	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
251221009774	DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cd00591
251221009775	DNA binding site [nucleotide binding]
251221009776	dimer interface [polypeptide binding]; other site
251221009777	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221009778	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221009779	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
251221009780	catalytic site [active]
251221009781	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
251221009782	homotrimer interaction site [polypeptide binding]; other site
251221009783	zinc binding site [ion binding]; other site
251221009784	CDP-binding sites; other site
251221009785	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
251221009786	substrate binding site [chemical binding]; other site
251221009787	hexamer interface [polypeptide binding]; other site
251221009788	metal binding site [ion binding]; metal-binding site
251221009789	Domain of unknown function (DUF1737); Region: DUF1737; cl10503
251221009790	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221009791	Ligand Binding Site [chemical binding]; other site
251221009792	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
251221009793	Cupin domain; Region: Cupin_2; pfam07883
251221009794	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
251221009795	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
251221009796	putative active site [active]
251221009797	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
251221009798	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
251221009799	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221009800	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221009801	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221009802	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221009803	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
251221009804	dimer interface [polypeptide binding]; other site
251221009805	active site
251221009806	metal binding site [ion binding]; metal-binding site
251221009807	glutathione binding site [chemical binding]; other site
251221009808	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
251221009809	CheB methylesterase; Region: CheB_methylest; pfam01339
251221009810	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
251221009811	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
251221009812	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
251221009813	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
251221009814	PAS domain; Region: PAS_10; pfam13596
251221009815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221009816	putative active site [active]
251221009817	heme pocket [chemical binding]; other site
251221009818	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221009819	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221009820	dimer interface [polypeptide binding]; other site
251221009821	phosphorylation site [posttranslational modification]
251221009822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221009823	ATP binding site [chemical binding]; other site
251221009824	Mg2+ binding site [ion binding]; other site
251221009825	G-X-G motif; other site
251221009826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221009827	active site
251221009828	phosphorylation site [posttranslational modification]
251221009829	intermolecular recognition site; other site
251221009830	dimerization interface [polypeptide binding]; other site
251221009831	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221009832	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
251221009833	ligand binding site [chemical binding]; other site
251221009834	flexible hinge region; other site
251221009835	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
251221009836	non-specific DNA interactions [nucleotide binding]; other site
251221009837	DNA binding site [nucleotide binding]
251221009838	sequence specific DNA binding site [nucleotide binding]; other site
251221009839	putative cAMP binding site [chemical binding]; other site
251221009840	Cell division protein ZapA; Region: ZapA; cl01146
251221009841	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
251221009842	TPR repeat; Region: TPR_11; pfam13414
251221009843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009844	binding surface
251221009845	TPR repeat; Region: TPR_11; pfam13414
251221009846	TPR motif; other site
251221009847	TPR repeat; Region: TPR_11; pfam13414
251221009848	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009849	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221009850	binding surface
251221009851	TPR motif; other site
251221009852	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
251221009853	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
251221009854	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
251221009855	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
251221009856	dimerization interface 3.5A [polypeptide binding]; other site
251221009857	active site
251221009858	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
251221009859	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
251221009860	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
251221009861	alphaNTD - beta interaction site [polypeptide binding]; other site
251221009862	alphaNTD homodimer interface [polypeptide binding]; other site
251221009863	alphaNTD - beta' interaction site [polypeptide binding]; other site
251221009864	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
251221009865	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
251221009866	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
251221009867	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
251221009868	RNA binding surface [nucleotide binding]; other site
251221009869	30S ribosomal protein S11; Validated; Region: PRK05309
251221009870	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
251221009871	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
251221009872	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
251221009873	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009874	binding surface
251221009875	TPR motif; other site
251221009876	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009877	binding surface
251221009878	TPR motif; other site
251221009879	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009880	binding surface
251221009881	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
251221009882	TPR motif; other site
251221009883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221009884	S-adenosylmethionine binding site [chemical binding]; other site
251221009885	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
251221009886	Clp amino terminal domain; Region: Clp_N; pfam02861
251221009887	Clp amino terminal domain; Region: Clp_N; pfam02861
251221009888	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221009889	Walker A motif; other site
251221009890	ATP binding site [chemical binding]; other site
251221009891	Walker B motif; other site
251221009892	arginine finger; other site
251221009893	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
251221009894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221009895	Walker A motif; other site
251221009896	ATP binding site [chemical binding]; other site
251221009897	Walker B motif; other site
251221009898	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
251221009899	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221009900	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
251221009901	active site
251221009902	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
251221009903	active site
251221009904	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
251221009905	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
251221009906	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
251221009907	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221009908	RNA polymerase sigma factor; Provisional; Region: PRK12518
251221009909	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221009910	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221009911	DNA binding residues [nucleotide binding]
251221009912	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
251221009913	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
251221009914	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
251221009915	active site
251221009916	catalytic site [active]
251221009917	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
251221009918	Tetratricopeptide repeat; Region: TPR_10; pfam13374
251221009919	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221009920	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009921	TPR motif; other site
251221009922	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221009923	binding surface
251221009924	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221009925	Tetratricopeptide repeat; Region: TPR_10; pfam13374
251221009926	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221009927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221009928	binding surface
251221009929	TPR motif; other site
251221009930	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221009931	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221009932	Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586
251221009933	CHAT domain; Region: CHAT; pfam12770
251221009934	Predicted transcriptional regulators [Transcription]; Region: COG1733
251221009935	dimerization interface [polypeptide binding]; other site
251221009936	putative DNA binding site [nucleotide binding]; other site
251221009937	putative Zn2+ binding site [ion binding]; other site
251221009938	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
251221009939	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
251221009940	NAD(P) binding site [chemical binding]; other site
251221009941	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
251221009942	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
251221009943	GIY-YIG motif/motif A; other site
251221009944	active site
251221009945	catalytic site [active]
251221009946	putative DNA binding site [nucleotide binding]; other site
251221009947	metal binding site [ion binding]; metal-binding site
251221009948	UvrB/uvrC motif; Region: UVR; pfam02151
251221009949	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
251221009950	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
251221009951	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
251221009952	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
251221009953	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221009954	putative active site [active]
251221009955	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221009956	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
251221009957	putative DNA binding site [nucleotide binding]; other site
251221009958	putative Zn2+ binding site [ion binding]; other site
251221009959	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
251221009960	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
251221009961	Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819
251221009962	putative heme binding site [chemical binding]; other site
251221009963	putative substrate binding site [chemical binding]; other site
251221009964	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
251221009965	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221009966	N-terminal plug; other site
251221009967	ligand-binding site [chemical binding]; other site
251221009968	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
251221009969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221009970	Walker A/P-loop; other site
251221009971	ATP binding site [chemical binding]; other site
251221009972	Q-loop/lid; other site
251221009973	ABC transporter signature motif; other site
251221009974	Walker B; other site
251221009975	D-loop; other site
251221009976	H-loop/switch region; other site
251221009977	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
251221009978	Glucose inhibited division protein A; Region: GIDA; pfam01134
251221009979	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
251221009980	Lumazine binding domain; Region: Lum_binding; pfam00677
251221009981	Lumazine binding domain; Region: Lum_binding; pfam00677
251221009982	Uncharacterized conserved protein [Function unknown]; Region: COG3791
251221009983	sucrose synthase; Region: sucr_synth; TIGR02470
251221009984	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
251221009985	putative ADP-binding pocket [chemical binding]; other site
251221009986	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
251221009987	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
251221009988	putative active site [active]
251221009989	putative metal binding site [ion binding]; other site
251221009990	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
251221009991	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
251221009992	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
251221009993	AlkA N-terminal domain; Region: AlkA_N; pfam06029
251221009994	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
251221009995	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
251221009996	minor groove reading motif; other site
251221009997	helix-hairpin-helix signature motif; other site
251221009998	substrate binding pocket [chemical binding]; other site
251221009999	active site
251221010000	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
251221010001	DNA binding site [nucleotide binding]
251221010002	active site
251221010003	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
251221010004	PhoH-like protein; Region: PhoH; pfam02562
251221010005	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
251221010006	RNA/DNA hybrid binding site [nucleotide binding]; other site
251221010007	active site
251221010008	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
251221010009	Tic22-like family; Region: Tic22; cl04468
251221010010	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
251221010011	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
251221010012	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221010013	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221010014	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221010015	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221010016	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221010017	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
251221010018	Outer membrane efflux protein; Region: OEP; pfam02321
251221010019	Outer membrane efflux protein; Region: OEP; pfam02321
251221010020	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
251221010021	MMPL family; Region: MMPL; cl14618
251221010022	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
251221010023	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
251221010024	catalytic residues [active]
251221010025	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
251221010026	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
251221010027	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
251221010028	catalytic loop [active]
251221010029	iron binding site [ion binding]; other site
251221010030	YtxH-like protein; Region: YtxH; pfam12732
251221010031	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
251221010032	diiron binding motif [ion binding]; other site
251221010033	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
251221010034	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
251221010035	Coenzyme A binding pocket [chemical binding]; other site
251221010036	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010037	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010038	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010039	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010040	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010041	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010042	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010043	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010044	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010045	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010046	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221010047	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
251221010048	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
251221010049	nucleotide binding site [chemical binding]; other site
251221010050	OstA-like protein; Region: OstA; cl00844
251221010051	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
251221010052	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
251221010053	active site
251221010054	Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; pfam02532
251221010055	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
251221010056	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
251221010057	putative NAD(P) binding site [chemical binding]; other site
251221010058	active site
251221010059	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221010060	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221010061	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
251221010062	MutS domain III; Region: MutS_III; pfam05192
251221010063	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
251221010064	Walker A/P-loop; other site
251221010065	ATP binding site [chemical binding]; other site
251221010066	Q-loop/lid; other site
251221010067	ABC transporter signature motif; other site
251221010068	Walker B; other site
251221010069	D-loop; other site
251221010070	H-loop/switch region; other site
251221010071	Smr domain; Region: Smr; pfam01713
251221010072	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221010073	putative active site [active]
251221010074	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
251221010075	EcsC protein family; Region: EcsC; pfam12787
251221010076	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
251221010077	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221010078	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
251221010079	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
251221010080	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
251221010081	active site
251221010082	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
251221010083	Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
251221010084	active site
251221010085	homodimer interface [polypeptide binding]; other site
251221010086	catalytic site [active]
251221010087	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
251221010088	terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835
251221010089	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
251221010090	putative active site [active]
251221010091	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
251221010092	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
251221010093	Probable Catalytic site; other site
251221010094	metal-binding site
251221010095	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
251221010096	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
251221010097	active site
251221010098	HIGH motif; other site
251221010099	nucleotide binding site [chemical binding]; other site
251221010100	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
251221010101	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
251221010102	active site
251221010103	KMSKS motif; other site
251221010104	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
251221010105	tRNA binding surface [nucleotide binding]; other site
251221010106	anticodon binding site; other site
251221010107	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
251221010108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221010109	S-adenosylmethionine binding site [chemical binding]; other site
251221010110	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
251221010111	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
251221010112	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
251221010113	DNA binding residues [nucleotide binding]
251221010114	putative dimer interface [polypeptide binding]; other site
251221010115	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
251221010116	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
251221010117	putative acyl-acceptor binding pocket; other site
251221010118	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221010119	binding surface
251221010120	TPR motif; other site
251221010121	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221010122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221010123	binding surface
251221010124	TPR motif; other site
251221010125	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221010126	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221010127	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221010128	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221010129	binding surface
251221010130	TPR motif; other site
251221010131	CHAT domain; Region: CHAT; pfam12770
251221010132	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
251221010133	Caspase domain; Region: Peptidase_C14; pfam00656
251221010134	AAA ATPase domain; Region: AAA_16; pfam13191
251221010135	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221010136	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221010137	structural tetrad; other site
251221010138	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221010139	structural tetrad; other site
251221010140	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221010141	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221010142	structural tetrad; other site
251221010143	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221010144	PAS fold; Region: PAS_3; pfam08447
251221010145	putative active site [active]
251221010146	heme pocket [chemical binding]; other site
251221010147	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
251221010148	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
251221010149	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
251221010150	DNA binding residues [nucleotide binding]
251221010151	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
251221010152	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
251221010153	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
251221010154	dihydroorotase; Provisional; Region: PRK07575
251221010155	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
251221010156	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
251221010157	active site
251221010158	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221010159	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221010160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221010161	Walker A/P-loop; other site
251221010162	ATP binding site [chemical binding]; other site
251221010163	Q-loop/lid; other site
251221010164	ABC transporter signature motif; other site
251221010165	Walker B; other site
251221010166	D-loop; other site
251221010167	H-loop/switch region; other site
251221010168	Domain of unknown function DUF39; Region: DUF39; pfam01837
251221010169	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221010170	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
251221010171	dimerization interface [polypeptide binding]; other site
251221010172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221010173	dimer interface [polypeptide binding]; other site
251221010174	phosphorylation site [posttranslational modification]
251221010175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221010176	ATP binding site [chemical binding]; other site
251221010177	Mg2+ binding site [ion binding]; other site
251221010178	G-X-G motif; other site
251221010179	ZIP Zinc transporter; Region: Zip; cl00437
251221010180	hydrolase, alpha/beta fold family protein; Region: PLN02824
251221010181	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221010182	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221010183	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221010184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221010185	binding surface
251221010186	TPR motif; other site
251221010187	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221010188	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
251221010189	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221010190	N-terminal plug; other site
251221010191	ligand-binding site [chemical binding]; other site
251221010192	glutathione synthetase; Provisional; Region: PRK05246
251221010193	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
251221010194	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
251221010195	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
251221010196	GSH binding site [chemical binding]; other site
251221010197	catalytic residues [active]
251221010198	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
251221010199	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
251221010200	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221010201	motif II; other site
251221010202	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
251221010203	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
251221010204	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
251221010205	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
251221010206	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
251221010207	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
251221010208	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
251221010209	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
251221010210	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
251221010211	RNA binding site [nucleotide binding]; other site
251221010212	active site
251221010213	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
251221010214	Manganese-stabilizing protein / photosystem II polypeptide; Region: MSP; cl03326
251221010215	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
251221010216	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
251221010217	dimer interface [polypeptide binding]; other site
251221010218	active site
251221010219	CoA binding pocket [chemical binding]; other site
251221010220	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
251221010221	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
251221010222	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
251221010223	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
251221010224	Zn2+ binding site [ion binding]; other site
251221010225	Mg2+ binding site [ion binding]; other site
251221010226	Endoribonuclease XendoU; Region: XendoU; pfam09412
251221010227	Lamin Tail Domain; Region: LTD; pfam00932
251221010228	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
251221010229	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
251221010230	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
251221010231	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
251221010232	catalytic triad [active]
251221010233	Peptidase family M41; Region: Peptidase_M41; pfam01434
251221010234	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
251221010235	putative active site; other site
251221010236	putative triphosphate binding site [ion binding]; other site
251221010237	putative metal binding residues [ion binding]; other site
251221010238	CP12 domain; Region: CP12; pfam02672
251221010239	PetN; Region: PetN; pfam03742
251221010240	PsaD; Region: PsaD; pfam02531
251221010241	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
251221010242	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
251221010243	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
251221010244	active site
251221010245	Substrate binding site; other site
251221010246	Mg++ binding site; other site
251221010247	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
251221010248	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
251221010249	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
251221010250	FAD binding domain; Region: FAD_binding_4; cl19922
251221010251	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
251221010252	colanic acid exporter; Provisional; Region: PRK10459
251221010253	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
251221010254	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
251221010255	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
251221010256	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139
251221010257	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
251221010258	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221010259	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
251221010260	putative ADP-binding pocket [chemical binding]; other site
251221010261	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221010262	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221010263	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
251221010264	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
251221010265	Chain length determinant protein; Region: Wzz; pfam02706
251221010266	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
251221010267	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
251221010268	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
251221010269	P-loop; other site
251221010270	Magnesium ion binding site [ion binding]; other site
251221010271	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
251221010272	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
251221010273	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
251221010274	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221010275	active site
251221010276	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
251221010277	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
251221010278	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
251221010279	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
251221010280	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221010281	PAS domain; Region: PAS_9; pfam13426
251221010282	putative active site [active]
251221010283	heme pocket [chemical binding]; other site
251221010284	Bacterial sugar transferase; Region: Bac_transf; pfam02397
251221010285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
251221010286	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
251221010287	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
251221010288	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
251221010289	active site
251221010290	metal binding site [ion binding]; metal-binding site
251221010291	cobalamin synthase; Reviewed; Region: cobS; PRK00235
251221010292	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
251221010293	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
251221010294	active site
251221010295	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
251221010296	Peptidase family M23; Region: Peptidase_M23; pfam01551
251221010297	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
251221010298	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
251221010299	NAD(P) binding site [chemical binding]; other site
251221010300	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
251221010301	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
251221010302	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
251221010303	metal binding site 2 [ion binding]; metal-binding site
251221010304	putative DNA binding helix; other site
251221010305	metal binding site 1 [ion binding]; metal-binding site
251221010306	dimer interface [polypeptide binding]; other site
251221010307	structural Zn2+ binding site [ion binding]; other site
251221010308	Rubrerythrin [Energy production and conversion]; Region: COG1592
251221010309	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
251221010310	binuclear metal center [ion binding]; other site
251221010311	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
251221010312	putative di-iron ligands [ion binding]; other site
251221010313	LexA regulated protein; Provisional; Region: PRK11675
251221010314	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
251221010315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221010316	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
251221010317	putative active site [active]
251221010318	heme pocket [chemical binding]; other site
251221010319	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221010320	putative active site [active]
251221010321	heme pocket [chemical binding]; other site
251221010322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221010323	PAS fold; Region: PAS_3; pfam08447
251221010324	putative active site [active]
251221010325	heme pocket [chemical binding]; other site
251221010326	GAF domain; Region: GAF; pfam01590
251221010327	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221010328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221010329	dimer interface [polypeptide binding]; other site
251221010330	phosphorylation site [posttranslational modification]
251221010331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221010332	ATP binding site [chemical binding]; other site
251221010333	Mg2+ binding site [ion binding]; other site
251221010334	G-X-G motif; other site
251221010335	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
251221010336	ligand binding site [chemical binding]; other site
251221010337	dimer interface [polypeptide binding]; other site
251221010338	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
251221010339	Mg++ binding site [ion binding]; other site
251221010340	putative catalytic motif [active]
251221010341	putative substrate binding site [chemical binding]; other site
251221010342	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
251221010343	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
251221010344	dimer interface [polypeptide binding]; other site
251221010345	putative functional site; other site
251221010346	putative MPT binding site; other site
251221010347	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
251221010348	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
251221010349	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
251221010350	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
251221010351	protein binding site [polypeptide binding]; other site
251221010352	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221010353	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221010354	DNA binding residues [nucleotide binding]
251221010355	dimerization interface [polypeptide binding]; other site
251221010356	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
251221010357	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
251221010358	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
251221010359	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
251221010360	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
251221010361	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
251221010362	catalytic site [active]
251221010363	putative active site [active]
251221010364	putative substrate binding site [chemical binding]; other site
251221010365	chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309
251221010366	ring oligomerisation interface [polypeptide binding]; other site
251221010367	ATP/Mg binding site [chemical binding]; other site
251221010368	hinge regions; other site
251221010369	stacking interactions; other site
251221010370	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
251221010371	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
251221010372	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
251221010373	active site
251221010374	catalytic tetrad [active]
251221010375	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
251221010376	DJ-1 family protein; Region: not_thiJ; TIGR01383
251221010377	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
251221010378	conserved cys residue [active]
251221010379	hypothetical protein; Reviewed; Region: PRK12497
251221010380	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
251221010381	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
251221010382	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
251221010383	active site
251221010384	TDP-binding site; other site
251221010385	acceptor substrate-binding pocket; other site
251221010386	homodimer interface [polypeptide binding]; other site
251221010387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
251221010388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221010389	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
251221010390	putative effector binding pocket; other site
251221010391	dimerization interface [polypeptide binding]; other site
251221010392	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
251221010393	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
251221010394	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
251221010395	Predicted esterase [General function prediction only]; Region: COG0400
251221010396	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
251221010397	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
251221010398	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
251221010399	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221010400	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
251221010401	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221010402	DNA binding residues [nucleotide binding]
251221010403	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
251221010404	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
251221010405	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
251221010406	active site
251221010407	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
251221010408	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
251221010409	oligomer interface [polypeptide binding]; other site
251221010410	active site residues [active]
251221010411	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
251221010412	oligomer interface [polypeptide binding]; other site
251221010413	active site residues [active]
251221010414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221010415	Walker A motif; other site
251221010416	ATP binding site [chemical binding]; other site
251221010417	Walker B motif; other site
251221010418	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
251221010419	RxxxH motif; other site
251221010420	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
251221010421	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
251221010422	Ferredoxin [Energy production and conversion]; Region: NapF; COG1145
251221010423	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
251221010424	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
251221010425	Radical SAM superfamily; Region: Radical_SAM; pfam04055
251221010426	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221010427	FeS/SAM binding site; other site
251221010428	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
251221010429	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
251221010430	NAD binding site [chemical binding]; other site
251221010431	putative substrate binding site 2 [chemical binding]; other site
251221010432	putative substrate binding site 1 [chemical binding]; other site
251221010433	active site
251221010434	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
251221010435	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221010436	active site
251221010437	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
251221010438	ligand binding site; other site
251221010439	tetramer interface; other site
251221010440	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
251221010441	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
251221010442	putative ligand binding site [chemical binding]; other site
251221010443	putative NAD binding site [chemical binding]; other site
251221010444	catalytic site [active]
251221010445	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
251221010446	classical (c) SDRs; Region: SDR_c; cd05233
251221010447	NAD(P) binding site [chemical binding]; other site
251221010448	active site
251221010449	Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050
251221010450	Methyltransferase domain; Region: Methyltransf_24; pfam13578
251221010451	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
251221010452	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
251221010453	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
251221010454	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
251221010455	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
251221010456	SLBB domain; Region: SLBB; pfam10531
251221010457	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
251221010458	Chain length determinant protein; Region: Wzz; pfam02706
251221010459	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
251221010460	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
251221010461	AAA domain; Region: AAA_31; pfam13614
251221010462	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
251221010463	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
251221010464	Probable Catalytic site; other site
251221010465	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
251221010466	metal-binding site
251221010467	putative glycosyl transferase; Provisional; Region: PRK10063
251221010468	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
251221010469	metal-binding site
251221010470	Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188
251221010471	Right handed beta helix region; Region: Beta_helix; pfam13229
251221010472	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
251221010473	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221010474	active site
251221010475	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
251221010476	CoA binding domain; Region: CoA_binding; cl17356
251221010477	Bacterial sugar transferase; Region: Bac_transf; pfam02397
251221010478	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
251221010479	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
251221010480	NADP binding site [chemical binding]; other site
251221010481	active site
251221010482	putative substrate binding site [chemical binding]; other site
251221010483	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
251221010484	active site
251221010485	metal binding site [ion binding]; metal-binding site
251221010486	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
251221010487	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
251221010488	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221010489	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
251221010490	putative active site [active]
251221010491	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
251221010492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
251221010493	Major Facilitator Superfamily; Region: MFS_1; pfam07690
251221010494	putative substrate translocation pore; other site
251221010495	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
251221010496	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
251221010497	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
251221010498	nucleotide binding site [chemical binding]; other site
251221010499	putative NEF/HSP70 interaction site [polypeptide binding]; other site
251221010500	SBD interface [polypeptide binding]; other site
251221010501	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
251221010502	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221010503	non-specific DNA binding site [nucleotide binding]; other site
251221010504	salt bridge; other site
251221010505	sequence-specific DNA binding site [nucleotide binding]; other site
251221010506	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
251221010507	dimer interface [polypeptide binding]; other site
251221010508	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
251221010509	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
251221010510	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
251221010511	Ycf46; Provisional; Region: ycf46; CHL00195
251221010512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221010513	Walker A motif; other site
251221010514	ATP binding site [chemical binding]; other site
251221010515	Walker B motif; other site
251221010516	arginine finger; other site
251221010517	periplasmic protein; Provisional; Region: PRK10568
251221010518	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
251221010519	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
251221010520	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
251221010521	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
251221010522	potential catalytic triad [active]
251221010523	conserved cys residue [active]
251221010524	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
251221010525	YCII-related domain; Region: YCII; cl00999
251221010526	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221010527	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221010528	putative active site [active]
251221010529	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
251221010530	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221010531	putative active site [active]
251221010532	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
251221010533	dimer interface [polypeptide binding]; other site
251221010534	[2Fe-2S] cluster binding site [ion binding]; other site
251221010535	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
251221010536	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
251221010537	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
251221010538	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
251221010539	alanine racemase; Reviewed; Region: alr; PRK00053
251221010540	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
251221010541	active site
251221010542	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
251221010543	dimer interface [polypeptide binding]; other site
251221010544	substrate binding site [chemical binding]; other site
251221010545	catalytic residues [active]
251221010546	dihydroorotase; Provisional; Region: PRK07369
251221010547	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
251221010548	active site
251221010549	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
251221010550	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
251221010551	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
251221010552	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
251221010553	putative active site [active]
251221010554	putative metal binding site [ion binding]; other site
251221010555	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
251221010556	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
251221010557	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
251221010558	dimer interface [polypeptide binding]; other site
251221010559	active site
251221010560	metal binding site [ion binding]; metal-binding site
251221010561	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
251221010562	active site
251221010563	FMN binding site [chemical binding]; other site
251221010564	substrate binding site [chemical binding]; other site
251221010565	homotetramer interface [polypeptide binding]; other site
251221010566	catalytic residue [active]
251221010567	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221010568	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
251221010569	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
251221010570	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
251221010571	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221010572	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221010573	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
251221010574	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
251221010575	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
251221010576	Transposase domain (DUF772); Region: DUF772; pfam05598
251221010577	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
251221010578	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
251221010579	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
251221010580	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
251221010581	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221010582	ATP binding site [chemical binding]; other site
251221010583	putative Mg++ binding site [ion binding]; other site
251221010584	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221010585	nucleotide binding region [chemical binding]; other site
251221010586	ATP-binding site [chemical binding]; other site
251221010587	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
251221010588	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
251221010589	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
251221010590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221010591	active site
251221010592	motif I; other site
251221010593	motif II; other site
251221010594	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
251221010595	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
251221010596	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
251221010597	putative ADP-binding pocket [chemical binding]; other site
251221010598	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
251221010599	S-layer homology domain; Region: SLH; pfam00395
251221010600	S-layer homology domain; Region: SLH; pfam00395
251221010601	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221010602	TPR repeat; Region: TPR_11; pfam13414
251221010603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221010604	binding surface
251221010605	TPR motif; other site
251221010606	TPR repeat; Region: TPR_11; pfam13414
251221010607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221010608	binding surface
251221010609	TPR motif; other site
251221010610	TPR repeat; Region: TPR_11; pfam13414
251221010611	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221010612	putative active site [active]
251221010613	Gkycosyl transferase family 4 group; Region: Glyco_trans_4_3; pfam12000
251221010614	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
251221010615	NAD binding site [chemical binding]; other site
251221010616	catalytic residues [active]
251221010617	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
251221010618	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
251221010619	inhibitor-cofactor binding pocket; inhibition site
251221010620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221010621	catalytic residue [active]
251221010622	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
251221010623	Predicted ATPase [General function prediction only]; Region: COG4637
251221010624	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221010625	Walker A/P-loop; other site
251221010626	ATP binding site [chemical binding]; other site
251221010627	AAA domain; Region: AAA_21; pfam13304
251221010628	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
251221010629	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
251221010630	ligand binding site [chemical binding]; other site
251221010631	flexible hinge region; other site
251221010632	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
251221010633	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
251221010634	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
251221010635	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
251221010636	DDE superfamily endonuclease; Region: DDE_3; cl19249
251221010637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
251221010638	Transposase; Region: HTH_Tnp_1; cl17663
251221010639	putative transposase OrfB; Reviewed; Region: PHA02517
251221010640	HTH-like domain; Region: HTH_21; pfam13276
251221010641	Integrase core domain; Region: rve; pfam00665
251221010642	Integrase core domain; Region: rve_3; pfam13683
251221010643	SnoaL-like domain; Region: SnoaL_2; pfam12680
251221010644	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221010645	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
251221010646	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221010647	binding surface
251221010648	TPR motif; other site
251221010649	Transcriptional regulators [Transcription]; Region: MarR; COG1846
251221010650	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
251221010651	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
251221010652	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
251221010653	GTP/Mg2+ binding site [chemical binding]; other site
251221010654	G4 box; other site
251221010655	G5 box; other site
251221010656	G1 box; other site
251221010657	Switch I region; other site
251221010658	G2 box; other site
251221010659	G3 box; other site
251221010660	Switch II region; other site
251221010661	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
251221010662	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
251221010663	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
251221010664	tetramer interface [polypeptide binding]; other site
251221010665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221010666	catalytic residue [active]
251221010667	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
251221010668	Mechanosensitive ion channel; Region: MS_channel; pfam00924
251221010669	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
251221010670	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
251221010671	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
251221010672	Protein of unknown function (DUF938); Region: DUF938; pfam06080
251221010673	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
251221010674	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
251221010675	oligomeric interface; other site
251221010676	putative active site [active]
251221010677	homodimer interface [polypeptide binding]; other site
251221010678	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
251221010679	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
251221010680	substrate binding site [chemical binding]; other site
251221010681	active site
251221010682	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221010683	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
251221010684	RNA polymerase sigma factor; Provisional; Region: PRK12514
251221010685	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
251221010686	Walker A motif; other site
251221010687	ATP binding site [chemical binding]; other site
251221010688	Walker B motif; other site
251221010689	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
251221010690	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
251221010691	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
251221010692	catalytic residues [active]
251221010693	catalytic nucleophile [active]
251221010694	Presynaptic Site I dimer interface [polypeptide binding]; other site
251221010695	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
251221010696	Synaptic Flat tetramer interface [polypeptide binding]; other site
251221010697	Synaptic Site I dimer interface [polypeptide binding]; other site
251221010698	DNA binding site [nucleotide binding]
251221010699	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
251221010700	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
251221010701	active site
251221010702	metal binding site [ion binding]; metal-binding site
251221010703	interdomain interaction site; other site
251221010704	Virulence-associated protein E; Region: VirE; pfam05272
251221010705	Coiled-coil domain-containing protein 14; Region: CCDC14; pfam15254
251221010706	Homeodomain-like domain; Region: HTH_23; pfam13384
251221010707	Predicted transcriptional regulator [Transcription]; Region: COG2345
251221010708	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
251221010709	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
251221010710	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
251221010711	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
251221010712	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
251221010713	dimer interface [polypeptide binding]; other site
251221010714	putative metal binding site [ion binding]; other site
251221010715	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
251221010716	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
251221010717	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
251221010718	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
251221010719	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
251221010720	23S rRNA interface [nucleotide binding]; other site
251221010721	L21e interface [polypeptide binding]; other site
251221010722	5S rRNA interface [nucleotide binding]; other site
251221010723	L27 interface [polypeptide binding]; other site
251221010724	L5 interface [polypeptide binding]; other site
251221010725	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
251221010726	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
251221010727	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
251221010728	ribosomal protein S8; Region: rps8; CHL00042
251221010729	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
251221010730	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
251221010731	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
251221010732	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
251221010733	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
251221010734	RNA binding site [nucleotide binding]; other site
251221010735	ribosomal protein L14; Region: rpl14; CHL00057
251221010736	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
251221010737	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
251221010738	putative translocon interaction site; other site
251221010739	23S rRNA interface [nucleotide binding]; other site
251221010740	signal recognition particle (SRP54) interaction site; other site
251221010741	L23 interface [polypeptide binding]; other site
251221010742	trigger factor interaction site; other site
251221010743	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
251221010744	23S rRNA interface [nucleotide binding]; other site
251221010745	5S rRNA interface [nucleotide binding]; other site
251221010746	putative antibiotic binding site [chemical binding]; other site
251221010747	L25 interface [polypeptide binding]; other site
251221010748	L27 interface [polypeptide binding]; other site
251221010749	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
251221010750	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
251221010751	G-X-X-G motif; other site
251221010752	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
251221010753	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
251221010754	putative translocon binding site; other site
251221010755	protein-rRNA interface [nucleotide binding]; other site
251221010756	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
251221010757	putative catalytic cysteine [active]
251221010758	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
251221010759	S17 interaction site [polypeptide binding]; other site
251221010760	S8 interaction site; other site
251221010761	16S rRNA interaction site [nucleotide binding]; other site
251221010762	streptomycin interaction site [chemical binding]; other site
251221010763	23S rRNA interaction site [nucleotide binding]; other site
251221010764	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
251221010765	30S ribosomal protein S7; Validated; Region: PRK05302
251221010766	elongation factor G; Reviewed; Region: PRK00007
251221010767	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
251221010768	G1 box; other site
251221010769	putative GEF interaction site [polypeptide binding]; other site
251221010770	GTP/Mg2+ binding site [chemical binding]; other site
251221010771	Switch I region; other site
251221010772	G2 box; other site
251221010773	G3 box; other site
251221010774	Switch II region; other site
251221010775	G4 box; other site
251221010776	G5 box; other site
251221010777	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
251221010778	Elongation Factor G, domain II; Region: EFG_II; pfam14492
251221010779	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
251221010780	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
251221010781	elongation factor Tu; Region: tufA; CHL00071
251221010782	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
251221010783	G1 box; other site
251221010784	GEF interaction site [polypeptide binding]; other site
251221010785	GTP/Mg2+ binding site [chemical binding]; other site
251221010786	Switch I region; other site
251221010787	G2 box; other site
251221010788	G3 box; other site
251221010789	Switch II region; other site
251221010790	G4 box; other site
251221010791	G5 box; other site
251221010792	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
251221010793	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
251221010794	Antibiotic Binding Site [chemical binding]; other site
251221010795	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
251221010796	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221010797	putative active site [active]
251221010798	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
251221010799	feedback inhibition sensing region; other site
251221010800	homohexameric interface [polypeptide binding]; other site
251221010801	nucleotide binding site [chemical binding]; other site
251221010802	N-acetyl-L-glutamate binding site [chemical binding]; other site
251221010803	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221010804	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374
251221010805	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
251221010806	active site
251221010807	PHP Thumb interface [polypeptide binding]; other site
251221010808	metal binding site [ion binding]; metal-binding site
251221010809	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
251221010810	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
251221010811	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
251221010812	generic binding surface I; other site
251221010813	generic binding surface II; other site
251221010814	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
251221010815	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
251221010816	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
251221010817	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
251221010818	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
251221010819	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
251221010820	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
251221010821	Phosphotransferase enzyme family; Region: APH; pfam01636
251221010822	active site
251221010823	substrate binding site [chemical binding]; other site
251221010824	ATP binding site [chemical binding]; other site
251221010825	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
251221010826	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
251221010827	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
251221010828	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221010829	motif II; other site
251221010830	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
251221010831	classical (c) SDRs; Region: SDR_c; cd05233
251221010832	NAD(P) binding site [chemical binding]; other site
251221010833	active site
251221010834	DDE superfamily endonuclease; Region: DDE_3; cl19249
251221010835	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221010836	TPR motif; other site
251221010837	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
251221010838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
251221010839	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
251221010840	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221010841	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
251221010842	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
251221010843	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221010844	catalytic residue [active]
251221010845	Homeodomain-like domain; Region: HTH_23; pfam13384
251221010846	Winged helix-turn helix; Region: HTH_29; pfam13551
251221010847	Homeodomain-like domain; Region: HTH_32; pfam13565
251221010848	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
251221010849	dimerization interface [polypeptide binding]; other site
251221010850	putative DNA binding site [nucleotide binding]; other site
251221010851	putative Zn2+ binding site [ion binding]; other site
251221010852	S-layer homology domain; Region: SLH; pfam00395
251221010853	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
251221010854	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221010855	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221010856	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221010857	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
251221010858	NMT1-like family; Region: NMT1_2; pfam13379
251221010859	MFS/sugar transport protein; Region: MFS_2; pfam13347
251221010860	putative symporter YagG; Provisional; Region: PRK09669; cl15392
251221010861	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
251221010862	Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520
251221010863	GUN4-like; Region: GUN4; pfam05419
251221010864	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
251221010865	Sulfite exporter TauE/SafE; Region: TauE; cl19196
251221010866	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
251221010867	DsbD alpha interface [polypeptide binding]; other site
251221010868	catalytic residues [active]
251221010869	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
251221010870	putative catalytic residue [active]
251221010871	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
251221010872	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
251221010873	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
251221010874	protein-splicing catalytic site; other site
251221010875	thioester formation/cholesterol transfer; other site
251221010876	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
251221010877	LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528
251221010878	LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528
251221010879	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
251221010880	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
251221010881	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
251221010882	protein-splicing catalytic site; other site
251221010883	thioester formation/cholesterol transfer; other site
251221010884	LAGLIDADG-like domain; Region: LAGLIDADG_3; pfam14528
251221010885	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
251221010886	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
251221010887	ATP-dependent protease La (LON) domain; Region: LON; cl19481
251221010888	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
251221010889	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
251221010890	hexamer interface [polypeptide binding]; other site
251221010891	ligand binding site [chemical binding]; other site
251221010892	putative active site [active]
251221010893	NAD(P) binding site [chemical binding]; other site
251221010894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221010895	S-adenosylmethionine binding site [chemical binding]; other site
251221010896	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221010897	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
251221010898	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
251221010899	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
251221010900	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
251221010901	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
251221010902	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221010903	putative active site [active]
251221010904	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
251221010905	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221010906	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221010907	N-terminal plug; other site
251221010908	ligand-binding site [chemical binding]; other site
251221010909	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221010910	putative active site [active]
251221010911	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
251221010912	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221010913	N-terminal plug; other site
251221010914	ligand-binding site [chemical binding]; other site
251221010915	YCII-related domain; Region: YCII; cl00999
251221010916	Predicted deacylase [General function prediction only]; Region: COG3608
251221010917	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253
251221010918	putative active site [active]
251221010919	Zn binding site [ion binding]; other site
251221010920	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253
251221010921	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
251221010922	putative active site [active]
251221010923	Zn binding site [ion binding]; other site
251221010924	DEAD-like helicases superfamily; Region: DEXDc; smart00487
251221010925	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
251221010926	ATP binding site [chemical binding]; other site
251221010927	putative Mg++ binding site [ion binding]; other site
251221010928	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
251221010929	nucleotide binding region [chemical binding]; other site
251221010930	ATP-binding site [chemical binding]; other site
251221010931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
251221010932	Protein of unknown function (DUF433); Region: DUF433; pfam04255
251221010933	phosphoglucomutase; Region: PLN02307
251221010934	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
251221010935	substrate binding site [chemical binding]; other site
251221010936	dimer interface [polypeptide binding]; other site
251221010937	active site
251221010938	metal binding site [ion binding]; metal-binding site
251221010939	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
251221010940	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221010941	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
251221010942	putative active site [active]
251221010943	heme pocket [chemical binding]; other site
251221010944	PAS domain; Region: PAS_8; pfam13188
251221010945	GAF domain; Region: GAF_2; pfam13185
251221010946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
251221010947	Histidine kinase; Region: HisKA_3; pfam07730
251221010948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221010949	ATP binding site [chemical binding]; other site
251221010950	Mg2+ binding site [ion binding]; other site
251221010951	G-X-G motif; other site
251221010952	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221010953	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221010954	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
251221010955	MMPL family; Region: MMPL; cl14618
251221010956	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
251221010957	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
251221010958	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
251221010959	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221010960	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
251221010961	dimerization interface [polypeptide binding]; other site
251221010962	Acylphosphatase; Region: Acylphosphatase; cl00551
251221010963	conserved hypothetical protein; Region: TIGR02246
251221010964	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
251221010965	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
251221010966	Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168
251221010967	isocitrate dehydrogenase; Validated; Region: PRK08299
251221010968	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
251221010969	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
251221010970	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
251221010971	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
251221010972	MutS domain III; Region: MutS_III; pfam05192
251221010973	ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283
251221010974	Walker A/P-loop; other site
251221010975	ATP binding site [chemical binding]; other site
251221010976	Q-loop/lid; other site
251221010977	ABC transporter signature motif; other site
251221010978	Walker B; other site
251221010979	D-loop; other site
251221010980	H-loop/switch region; other site
251221010981	Bacterial SH3 domain; Region: SH3_3; pfam08239
251221010982	NlpC/P60 family; Region: NLPC_P60; pfam00877
251221010983	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
251221010984	Protein of unknown function (DUF561); Region: DUF561; pfam04481
251221010985	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
251221010986	homotrimer interaction site [polypeptide binding]; other site
251221010987	putative active site [active]
251221010988	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
251221010989	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
251221010990	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
251221010991	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
251221010992	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
251221010993	binuclear metal center [ion binding]; other site
251221010994	Rubrerythrin [Energy production and conversion]; Region: COG1592
251221010995	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
251221010996	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
251221010997	putative active site [active]
251221010998	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221010999	putative active site [active]
251221011000	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
251221011001	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
251221011002	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
251221011003	dimer interface [polypeptide binding]; other site
251221011004	active site
251221011005	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
251221011006	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
251221011007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221011008	FeS/SAM binding site; other site
251221011009	TRAM domain; Region: TRAM; pfam01938
251221011010	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
251221011011	active site
251221011012	(T/H)XGH motif; other site
251221011013	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
251221011014	active site
251221011015	ATP binding site [chemical binding]; other site
251221011016	substrate binding site [chemical binding]; other site
251221011017	activation loop (A-loop); other site
251221011018	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
251221011019	methionine sulfoxide reductase B; Provisional; Region: PRK00222
251221011020	PAAR motif; Region: PAAR_motif; cl15808
251221011021	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
251221011022	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
251221011023	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
251221011024	16S/18S rRNA binding site [nucleotide binding]; other site
251221011025	S13e-L30e interaction site [polypeptide binding]; other site
251221011026	25S rRNA binding site [nucleotide binding]; other site
251221011027	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
251221011028	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
251221011029	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221011030	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
251221011031	MMPL family; Region: MMPL; cl14618
251221011032	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011033	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221011034	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011035	TIR domain; Region: TIR_2; pfam13676
251221011036	BioY family; Region: BioY; pfam02632
251221011037	Protein of unknown function (DUF751); Region: DUF751; pfam05421
251221011038	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
251221011039	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
251221011040	heterotetramer interface [polypeptide binding]; other site
251221011041	active site pocket [active]
251221011042	cleavage site
251221011043	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221011044	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221011045	DNA binding residues [nucleotide binding]
251221011046	dimerization interface [polypeptide binding]; other site
251221011047	Protein of unknown function, DUF482; Region: DUF482; pfam04339
251221011048	NurA nuclease; Region: NurA; smart00933
251221011049	RF-1 domain; Region: RF-1; pfam00472
251221011050	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
251221011051	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
251221011052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
251221011053	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
251221011054	catalytic residues [active]
251221011055	dimer interface [polypeptide binding]; other site
251221011056	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
251221011057	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
251221011058	putative homodimer interface [polypeptide binding]; other site
251221011059	putative homotetramer interface [polypeptide binding]; other site
251221011060	allosteric switch controlling residues; other site
251221011061	putative metal binding site [ion binding]; other site
251221011062	putative homodimer-homodimer interface [polypeptide binding]; other site
251221011063	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
251221011064	metal-binding site [ion binding]
251221011065	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
251221011066	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
251221011067	metal-binding site [ion binding]
251221011068	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
251221011069	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
251221011070	motif II; other site
251221011071	nickel responsive regulator; Provisional; Region: PRK00630
251221011072	PemK-like protein; Region: PemK; pfam02452
251221011073	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
251221011074	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
251221011075	Fasciclin domain; Region: Fasciclin; pfam02469
251221011076	amidase; Provisional; Region: PRK06828
251221011077	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
251221011078	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221011079	active site
251221011080	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
251221011081	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
251221011082	Active site cavity [active]
251221011083	catalytic acid [active]
251221011084	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
251221011085	active site lid residues [active]
251221011086	substrate binding pocket [chemical binding]; other site
251221011087	catalytic residues [active]
251221011088	substrate-Mg2+ binding site; other site
251221011089	aspartate-rich region 1; other site
251221011090	aspartate-rich region 2; other site
251221011091	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
251221011092	active site
251221011093	metal binding site [ion binding]; metal-binding site
251221011094	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
251221011095	putative active site [active]
251221011096	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221011097	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221011098	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221011099	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221011100	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
251221011101	transposase; Validated; Region: PRK08181
251221011102	Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823
251221011103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221011104	Walker A motif; other site
251221011105	ATP binding site [chemical binding]; other site
251221011106	Walker B motif; other site
251221011107	Integrase core domain; Region: rve; pfam00665
251221011108	arginine decarboxylase; Provisional; Region: PRK05354
251221011109	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
251221011110	dimer interface [polypeptide binding]; other site
251221011111	active site
251221011112	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
251221011113	catalytic residues [active]
251221011114	substrate binding site [chemical binding]; other site
251221011115	RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6
251221011116	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
251221011117	DNA binding residues [nucleotide binding]
251221011118	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
251221011119	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221011120	active site
251221011121	ATP binding site [chemical binding]; other site
251221011122	substrate binding site [chemical binding]; other site
251221011123	activation loop (A-loop); other site
251221011124	Predicted integral membrane protein [Function unknown]; Region: COG5616
251221011125	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
251221011126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011127	binding surface
251221011128	TPR motif; other site
251221011129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011130	binding surface
251221011131	TPR motif; other site
251221011132	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011133	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011134	Homeodomain-like domain; Region: HTH_23; cl17451
251221011135	Winged helix-turn helix; Region: HTH_29; pfam13551
251221011136	DDE superfamily endonuclease; Region: DDE_3; pfam13358
251221011137	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
251221011138	generic binding surface II; other site
251221011139	generic binding surface I; other site
251221011140	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
251221011141	putative active site [active]
251221011142	putative catalytic site [active]
251221011143	putative Mg binding site IVb [ion binding]; other site
251221011144	putative phosphate binding site [ion binding]; other site
251221011145	putative DNA binding site [nucleotide binding]; other site
251221011146	putative Mg binding site IVa [ion binding]; other site
251221011147	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
251221011148	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
251221011149	putative active site [active]
251221011150	catalytic site [active]
251221011151	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
251221011152	putative active site [active]
251221011153	catalytic site [active]
251221011154	hypothetical protein; Provisional; Region: PRK05421
251221011155	putative catalytic site [active]
251221011156	putative metal binding site [ion binding]; other site
251221011157	putative phosphate binding site [ion binding]; other site
251221011158	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221011159	putative active site [active]
251221011160	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
251221011161	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
251221011162	active site
251221011163	HIGH motif; other site
251221011164	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
251221011165	KMSKS motif; other site
251221011166	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
251221011167	tRNA binding surface [nucleotide binding]; other site
251221011168	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
251221011169	DNA primase; Validated; Region: dnaG; PRK05667
251221011170	CHC2 zinc finger; Region: zf-CHC2; pfam01807
251221011171	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
251221011172	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
251221011173	active site
251221011174	metal binding site [ion binding]; metal-binding site
251221011175	interdomain interaction site; other site
251221011176	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
251221011177	aconitate hydratase; Validated; Region: PRK07229
251221011178	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
251221011179	substrate binding site [chemical binding]; other site
251221011180	ligand binding site [chemical binding]; other site
251221011181	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
251221011182	substrate binding site [chemical binding]; other site
251221011183	TPR repeat; Region: TPR_11; pfam13414
251221011184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011185	binding surface
251221011186	TPR motif; other site
251221011187	TPR repeat; Region: TPR_11; pfam13414
251221011188	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221011189	putative active site [active]
251221011190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221011191	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011192	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011194	TPR motif; other site
251221011195	binding surface
251221011196	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011197	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011199	binding surface
251221011200	TPR motif; other site
251221011201	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011203	binding surface
251221011204	TPR motif; other site
251221011205	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011206	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011207	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011208	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011209	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011210	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011211	binding surface
251221011212	TPR motif; other site
251221011213	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011215	binding surface
251221011216	TPR motif; other site
251221011217	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011218	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011219	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011220	binding surface
251221011221	TPR motif; other site
251221011222	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011223	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221011224	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
251221011225	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221011226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011227	active site
251221011228	phosphorylation site [posttranslational modification]
251221011229	intermolecular recognition site; other site
251221011230	dimerization interface [polypeptide binding]; other site
251221011231	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221011232	DNA binding residues [nucleotide binding]
251221011233	dimerization interface [polypeptide binding]; other site
251221011234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
251221011235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221011236	ATP binding site [chemical binding]; other site
251221011237	Mg2+ binding site [ion binding]; other site
251221011238	G-X-G motif; other site
251221011239	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
251221011240	Domain of unknown function (DUF4480); Region: DUF4480; pfam13715
251221011241	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
251221011242	conserved hypothetical phage tail region protein; Region: TIGR02241
251221011243	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
251221011244	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
251221011245	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
251221011246	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
251221011247	Catalytic domain of Protein Kinases; Region: PKc; cd00180
251221011248	active site
251221011249	ATP binding site [chemical binding]; other site
251221011250	substrate binding site [chemical binding]; other site
251221011251	activation loop (A-loop); other site
251221011252	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
251221011253	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
251221011254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
251221011255	homodimer interface [polypeptide binding]; other site
251221011256	catalytic residue [active]
251221011257	S-layer homology domain; Region: SLH; pfam00395
251221011258	S-layer homology domain; Region: SLH; pfam00395
251221011259	S-layer homology domain; Region: SLH; pfam00395
251221011260	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
251221011261	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
251221011262	putative NAD(P) binding site [chemical binding]; other site
251221011263	putative substrate binding site [chemical binding]; other site
251221011264	catalytic Zn binding site [ion binding]; other site
251221011265	structural Zn binding site [ion binding]; other site
251221011266	S-layer homology domain; Region: SLH; pfam00395
251221011267	S-layer homology domain; Region: SLH; pfam00395
251221011268	S-layer homology domain; Region: SLH; pfam00395
251221011269	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011270	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
251221011271	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
251221011272	Walker A/P-loop; other site
251221011273	ATP binding site [chemical binding]; other site
251221011274	Q-loop/lid; other site
251221011275	ABC transporter signature motif; other site
251221011276	Walker B; other site
251221011277	D-loop; other site
251221011278	H-loop/switch region; other site
251221011279	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
251221011280	mce related protein; Region: MCE; pfam02470
251221011281	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
251221011282	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
251221011283	ribonuclease Z; Region: RNase_Z; TIGR02651
251221011284	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011285	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011286	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011287	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011288	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011289	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221011290	putative active site [active]
251221011291	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
251221011292	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
251221011293	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
251221011294	Walker A/P-loop; other site
251221011295	ATP binding site [chemical binding]; other site
251221011296	Q-loop/lid; other site
251221011297	ABC transporter signature motif; other site
251221011298	Walker B; other site
251221011299	D-loop; other site
251221011300	H-loop/switch region; other site
251221011301	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
251221011302	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
251221011303	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
251221011304	Walker A/P-loop; other site
251221011305	ATP binding site [chemical binding]; other site
251221011306	Q-loop/lid; other site
251221011307	ABC transporter signature motif; other site
251221011308	Walker B; other site
251221011309	D-loop; other site
251221011310	H-loop/switch region; other site
251221011311	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
251221011312	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
251221011313	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
251221011314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221011315	dimer interface [polypeptide binding]; other site
251221011316	conserved gate region; other site
251221011317	putative PBP binding loops; other site
251221011318	ABC-ATPase subunit interface; other site
251221011319	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
251221011320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221011321	dimer interface [polypeptide binding]; other site
251221011322	conserved gate region; other site
251221011323	putative PBP binding loops; other site
251221011324	ABC-ATPase subunit interface; other site
251221011325	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
251221011326	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
251221011327	peptide binding site [polypeptide binding]; other site
251221011328	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
251221011329	proposed catalytic triad [active]
251221011330	active site nucleophile [active]
251221011331	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221011332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011333	active site
251221011334	phosphorylation site [posttranslational modification]
251221011335	intermolecular recognition site; other site
251221011336	dimerization interface [polypeptide binding]; other site
251221011337	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221011338	DNA binding site [nucleotide binding]
251221011339	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
251221011340	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
251221011341	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
251221011342	Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201
251221011343	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
251221011344	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
251221011345	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221011346	Walker A/P-loop; other site
251221011347	ATP binding site [chemical binding]; other site
251221011348	Q-loop/lid; other site
251221011349	ABC transporter signature motif; other site
251221011350	Walker B; other site
251221011351	D-loop; other site
251221011352	H-loop/switch region; other site
251221011353	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
251221011354	TPR repeat; Region: TPR_11; pfam13414
251221011355	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011356	binding surface
251221011357	TPR motif; other site
251221011358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011359	binding surface
251221011360	TPR motif; other site
251221011361	TPR repeat; Region: TPR_11; pfam13414
251221011362	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011363	TPR motif; other site
251221011364	binding surface
251221011365	TPR repeat; Region: TPR_11; pfam13414
251221011366	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011367	binding surface
251221011368	TPR motif; other site
251221011369	TPR repeat; Region: TPR_11; pfam13414
251221011370	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
251221011371	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
251221011372	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
251221011373	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
251221011374	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
251221011375	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
251221011376	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
251221011377	putative dimer interface [polypeptide binding]; other site
251221011378	active site pocket [active]
251221011379	putative cataytic base [active]
251221011380	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
251221011381	catalytic site [active]
251221011382	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
251221011383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221011384	dimer interface [polypeptide binding]; other site
251221011385	conserved gate region; other site
251221011386	putative PBP binding loops; other site
251221011387	ABC-ATPase subunit interface; other site
251221011388	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
251221011389	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
251221011390	HflX GTPase family; Region: HflX; cd01878
251221011391	G1 box; other site
251221011392	GTP/Mg2+ binding site [chemical binding]; other site
251221011393	Switch I region; other site
251221011394	G2 box; other site
251221011395	G3 box; other site
251221011396	Switch II region; other site
251221011397	G4 box; other site
251221011398	G5 box; other site
251221011399	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
251221011400	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
251221011401	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
251221011402	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
251221011403	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
251221011404	Death-like domain of SPT6; Region: DLD; pfam14878
251221011405	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
251221011406	RNA binding site [nucleotide binding]; other site
251221011407	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
251221011408	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
251221011409	active site
251221011410	Zn binding site [ion binding]; other site
251221011411	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
251221011412	Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528
251221011413	active site residue [active]
251221011414	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
251221011415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
251221011416	Uncharacterized conserved protein [Function unknown]; Region: COG1543
251221011417	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
251221011418	active site
251221011419	substrate binding site [chemical binding]; other site
251221011420	catalytic site [active]
251221011421	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
251221011422	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221011423	putative active site [active]
251221011424	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
251221011425	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
251221011426	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
251221011427	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
251221011428	putative NADP binding site [chemical binding]; other site
251221011429	putative substrate binding site [chemical binding]; other site
251221011430	active site
251221011431	Predicted transcriptional regulators [Transcription]; Region: COG1695
251221011432	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
251221011433	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
251221011434	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
251221011435	Domain of unknown function DUF29; Region: DUF29; pfam01724
251221011436	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
251221011437	metal binding site [ion binding]; metal-binding site
251221011438	nucleotidyl binding site; other site
251221011439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011440	active site
251221011441	phosphorylation site [posttranslational modification]
251221011442	intermolecular recognition site; other site
251221011443	dimerization interface [polypeptide binding]; other site
251221011444	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
251221011445	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221011446	putative active site [active]
251221011447	heme pocket [chemical binding]; other site
251221011448	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221011449	dimer interface [polypeptide binding]; other site
251221011450	phosphorylation site [posttranslational modification]
251221011451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221011452	ATP binding site [chemical binding]; other site
251221011453	Mg2+ binding site [ion binding]; other site
251221011454	G-X-G motif; other site
251221011455	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221011456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011457	active site
251221011458	phosphorylation site [posttranslational modification]
251221011459	intermolecular recognition site; other site
251221011460	dimerization interface [polypeptide binding]; other site
251221011461	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221011462	DNA binding site [nucleotide binding]
251221011463	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
251221011464	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
251221011465	phosphate binding site [ion binding]; other site
251221011466	putative substrate binding pocket [chemical binding]; other site
251221011467	dimer interface [polypeptide binding]; other site
251221011468	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
251221011469	putative hydrophobic ligand binding site [chemical binding]; other site
251221011470	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
251221011471	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
251221011472	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
251221011473	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
251221011474	Protein export membrane protein; Region: SecD_SecF; pfam02355
251221011475	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221011476	Ligand Binding Site [chemical binding]; other site
251221011477	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
251221011478	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
251221011479	MMPL family; Region: MMPL; cl14618
251221011480	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
251221011481	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
251221011482	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
251221011483	HlyD family secretion protein; Region: HlyD_3; pfam13437
251221011484	Penicillinase repressor; Region: Penicillinase_R; pfam03965
251221011485	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
251221011486	Peptidase family M48; Region: Peptidase_M48; cl12018
251221011487	Uncharacterized conserved protein [Function unknown]; Region: COG1742
251221011488	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
251221011489	EamA-like transporter family; Region: EamA; pfam00892
251221011490	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
251221011491	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
251221011492	active site
251221011493	ATP binding site [chemical binding]; other site
251221011494	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
251221011495	anti sigma factor interaction site; other site
251221011496	regulatory phosphorylation site [posttranslational modification]; other site
251221011497	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
251221011498	metal binding site [ion binding]; metal-binding site
251221011499	Pox virus Ag35 surface protein; Region: Pox_Ag35; pfam03286
251221011500	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
251221011501	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
251221011502	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
251221011503	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
251221011504	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
251221011505	Cl- selectivity filter; other site
251221011506	Cl- binding residues [ion binding]; other site
251221011507	pore gating glutamate residue; other site
251221011508	dimer interface [polypeptide binding]; other site
251221011509	H+/Cl- coupling transport residue; other site
251221011510	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
251221011511	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
251221011512	Ligand Binding Site [chemical binding]; other site
251221011513	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221011514	Ligand Binding Site [chemical binding]; other site
251221011515	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
251221011516	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
251221011517	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
251221011518	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
251221011519	NAD binding site [chemical binding]; other site
251221011520	homotetramer interface [polypeptide binding]; other site
251221011521	homodimer interface [polypeptide binding]; other site
251221011522	substrate binding site [chemical binding]; other site
251221011523	active site
251221011524	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
251221011525	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
251221011526	Transposase, Mutator family; Region: Transposase_mut; cl19537
251221011527	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
251221011528	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
251221011529	Transposase, Mutator family; Region: Transposase_mut; cl19537
251221011530	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
251221011531	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
251221011532	putative active site [active]
251221011533	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
251221011534	putative active site [active]
251221011535	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
251221011536	dimer interface [polypeptide binding]; other site
251221011537	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
251221011538	trigger factor; Provisional; Region: tig; PRK01490
251221011539	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
251221011540	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
251221011541	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
251221011542	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
251221011543	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
251221011544	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221011545	Walker A motif; other site
251221011546	ATP binding site [chemical binding]; other site
251221011547	Walker B motif; other site
251221011548	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
251221011549	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
251221011550	Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932
251221011551	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
251221011552	AMP-binding enzyme; Region: AMP-binding; pfam00501
251221011553	acyl-activating enzyme (AAE) consensus motif; other site
251221011554	Beta-propeller repeat; Region: SBBP; pfam06739
251221011555	Beta-propeller repeat; Region: SBBP; pfam06739
251221011556	Beta-propeller repeat; Region: SBBP; pfam06739
251221011557	Beta-propeller repeat; Region: SBBP; pfam06739
251221011558	Beta-propeller repeat; Region: SBBP; pfam06739
251221011559	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
251221011560	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221011561	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
251221011562	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
251221011563	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
251221011564	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
251221011565	NADP binding site [chemical binding]; other site
251221011566	homodimer interface [polypeptide binding]; other site
251221011567	active site
251221011568	substrate binding site [chemical binding]; other site
251221011569	Predicted transcriptional regulators [Transcription]; Region: COG1733
251221011570	dimerization interface [polypeptide binding]; other site
251221011571	putative DNA binding site [nucleotide binding]; other site
251221011572	putative Zn2+ binding site [ion binding]; other site
251221011573	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
251221011574	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
251221011575	tandem repeat interface [polypeptide binding]; other site
251221011576	oligomer interface [polypeptide binding]; other site
251221011577	active site residues [active]
251221011578	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
251221011579	tandem repeat interface [polypeptide binding]; other site
251221011580	oligomer interface [polypeptide binding]; other site
251221011581	active site residues [active]
251221011582	Uncharacterized conserved protein [Function unknown]; Region: COG2442
251221011583	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
251221011584	Mnt; Region: mnt; PHA01513
251221011585	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
251221011586	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
251221011587	Walker A/P-loop; other site
251221011588	ATP binding site [chemical binding]; other site
251221011589	Q-loop/lid; other site
251221011590	ABC transporter signature motif; other site
251221011591	Walker B; other site
251221011592	D-loop; other site
251221011593	H-loop/switch region; other site
251221011594	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
251221011595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011596	active site
251221011597	phosphorylation site [posttranslational modification]
251221011598	intermolecular recognition site; other site
251221011599	dimerization interface [polypeptide binding]; other site
251221011600	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
251221011601	DNA binding site [nucleotide binding]
251221011602	Hpt domain; Region: Hpt; pfam01627
251221011603	putative binding surface; other site
251221011604	active site
251221011605	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011606	active site
251221011607	phosphorylation site [posttranslational modification]
251221011608	intermolecular recognition site; other site
251221011609	dimerization interface [polypeptide binding]; other site
251221011610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011611	active site
251221011612	phosphorylation site [posttranslational modification]
251221011613	intermolecular recognition site; other site
251221011614	dimerization interface [polypeptide binding]; other site
251221011615	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221011616	PAS domain; Region: PAS_9; pfam13426
251221011617	putative active site [active]
251221011618	heme pocket [chemical binding]; other site
251221011619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221011620	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
251221011621	putative active site [active]
251221011622	heme pocket [chemical binding]; other site
251221011623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221011624	dimer interface [polypeptide binding]; other site
251221011625	phosphorylation site [posttranslational modification]
251221011626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221011627	ATP binding site [chemical binding]; other site
251221011628	Mg2+ binding site [ion binding]; other site
251221011629	G-X-G motif; other site
251221011630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011631	active site
251221011632	phosphorylation site [posttranslational modification]
251221011633	intermolecular recognition site; other site
251221011634	dimerization interface [polypeptide binding]; other site
251221011635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221011636	active site
251221011637	phosphorylation site [posttranslational modification]
251221011638	intermolecular recognition site; other site
251221011639	dimerization interface [polypeptide binding]; other site
251221011640	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
251221011641	Ligand Binding Site [chemical binding]; other site
251221011642	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
251221011643	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
251221011644	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
251221011645	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
251221011646	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
251221011647	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
251221011648	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011649	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011650	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011651	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
251221011652	Protein of unknown function (DUF1501); Region: DUF1501; cl19855
251221011653	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221011654	putative active site [active]
251221011655	Uncharacterized conserved protein [Function unknown]; Region: COG3379
251221011656	Phosphopantetheine attachment site; Region: PP-binding; cl09936
251221011657	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
251221011658	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221011659	active site
251221011660	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
251221011661	Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152
251221011662	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
251221011663	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
251221011664	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
251221011665	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
251221011666	phosphate binding site [ion binding]; other site
251221011667	2-Nitropropane dioxygenase (NPD)-like domain, associated with polyketide synthases (PKS). NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and...; Region: NPD_PKS; cd04743
251221011668	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
251221011669	FMN binding site [chemical binding]; other site
251221011670	substrate binding site [chemical binding]; other site
251221011671	putative catalytic residue [active]
251221011672	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
251221011673	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
251221011674	active site
251221011675	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
251221011676	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
251221011677	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
251221011678	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
251221011679	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
251221011680	putative NADP binding site [chemical binding]; other site
251221011681	active site
251221011682	Polyketide synthase dehydratase; Region: PS-DH; pfam14765
251221011683	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
251221011684	dimer interface [polypeptide binding]; other site
251221011685	substrate binding site [chemical binding]; other site
251221011686	metal binding sites [ion binding]; metal-binding site
251221011687	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
251221011688	tetramerization interface [polypeptide binding]; other site
251221011689	active site
251221011690	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
251221011691	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
251221011692	DXD motif; other site
251221011693	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
251221011694	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
251221011695	translocation protein TolB; Provisional; Region: tolB; PRK01029
251221011696	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
251221011697	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
251221011698	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
251221011699	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
251221011700	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
251221011701	Predicted transcriptional regulator [Transcription]; Region: COG3905
251221011702	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
251221011703	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
251221011704	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
251221011705	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221011706	FeS/SAM binding site; other site
251221011707	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
251221011708	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
251221011709	Active_site [active]
251221011710	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
251221011711	hypothetical protein; Provisional; Region: PRK07208
251221011712	UDP-galactopyranose mutase; Region: GLF; pfam03275
251221011713	GtrA-like protein; Region: GtrA; pfam04138
251221011714	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
251221011715	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
251221011716	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221011717	Beta-propeller repeat; Region: SBBP; pfam06739
251221011718	Beta-propeller repeat; Region: SBBP; pfam06739
251221011719	Beta-propeller repeat; Region: SBBP; pfam06739
251221011720	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011721	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011722	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011723	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
251221011724	HSP70 interaction site [polypeptide binding]; other site
251221011725	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221011726	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011727	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011728	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
251221011729	putative symporter YagG; Provisional; Region: PRK09669; cl15392
251221011730	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
251221011731	Kelch motif; Region: Kelch_6; pfam13964
251221011732	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
251221011733	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011734	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
251221011735	Predicted transcriptional regulators [Transcription]; Region: COG1725
251221011736	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
251221011737	DNA-binding site [nucleotide binding]; DNA binding site
251221011738	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
251221011739	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
251221011740	NodB motif; other site
251221011741	active site
251221011742	catalytic site [active]
251221011743	metal binding site [ion binding]; metal-binding site
251221011744	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
251221011745	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
251221011746	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221011747	sequence-specific DNA binding site [nucleotide binding]; other site
251221011748	salt bridge; other site
251221011749	Domain of unknown function (DUF955); Region: DUF955; cl01076
251221011750	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
251221011751	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
251221011752	active site
251221011753	dimer interface [polypeptide binding]; other site
251221011754	non-prolyl cis peptide bond; other site
251221011755	insertion regions; other site
251221011756	ATP-grasp domain; Region: ATP-grasp_4; cl17255
251221011757	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
251221011758	Putative lysophospholipase; Region: Hydrolase_4; cl19140
251221011759	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
251221011760	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
251221011761	ligand binding site; other site
251221011762	oligomer interface; other site
251221011763	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
251221011764	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
251221011765	dimer interface [polypeptide binding]; other site
251221011766	N-terminal domain interface [polypeptide binding]; other site
251221011767	sulfate 1 binding site; other site
251221011768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
251221011769	TPR motif; other site
251221011770	Tetratricopeptide repeat; Region: TPR_12; pfam13424
251221011771	binding surface
251221011772	Tetratricopeptide repeat; Region: TPR_16; pfam13432
251221011773	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
251221011774	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
251221011775	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
251221011776	nucleotide binding site [chemical binding]; other site
251221011777	NEF interaction site [polypeptide binding]; other site
251221011778	SBD interface [polypeptide binding]; other site
251221011779	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
251221011780	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
251221011781	chaperone protein DnaJ; Provisional; Region: PRK14293
251221011782	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
251221011783	HSP70 interaction site [polypeptide binding]; other site
251221011784	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
251221011785	substrate binding site [polypeptide binding]; other site
251221011786	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
251221011787	Zn binding sites [ion binding]; other site
251221011788	dimer interface [polypeptide binding]; other site
251221011789	GTPase RsgA; Reviewed; Region: PRK12289
251221011790	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
251221011791	RNA binding site [nucleotide binding]; other site
251221011792	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
251221011793	GTPase/Zn-binding domain interface [polypeptide binding]; other site
251221011794	GTP/Mg2+ binding site [chemical binding]; other site
251221011795	G4 box; other site
251221011796	G5 box; other site
251221011797	G1 box; other site
251221011798	Switch I region; other site
251221011799	G2 box; other site
251221011800	G3 box; other site
251221011801	Switch II region; other site
251221011802	TIGR04255 family protein; Region: sporadTIGR04255
251221011803	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
251221011804	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
251221011805	Moco binding site; other site
251221011806	metal coordination site [ion binding]; other site
251221011807	Entner-Doudoroff aldolase; Region: eda; TIGR01182
251221011808	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
251221011809	active site
251221011810	intersubunit interface [polypeptide binding]; other site
251221011811	catalytic residue [active]
251221011812	MAPEG family; Region: MAPEG; cl09190
251221011813	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
251221011814	Fasciclin domain; Region: Fasciclin; pfam02469
251221011815	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
251221011816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221011817	putative PBP binding loops; other site
251221011818	ABC-ATPase subunit interface; other site
251221011819	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
251221011820	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
251221011821	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
251221011822	beta and beta' interface [polypeptide binding]; other site
251221011823	beta' and sigma factor interface [polypeptide binding]; other site
251221011824	Zn-binding [ion binding]; other site
251221011825	active site region [active]
251221011826	catalytic site [active]
251221011827	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
251221011828	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
251221011829	Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114
251221011830	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
251221011831	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
251221011832	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
251221011833	DNA binding site [nucleotide binding]
251221011834	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
251221011835	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
251221011836	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
251221011837	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
251221011838	active site
251221011839	HIGH motif; other site
251221011840	KMSK motif region; other site
251221011841	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
251221011842	tRNA binding surface [nucleotide binding]; other site
251221011843	anticodon binding site; other site
251221011844	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
251221011845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
251221011846	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
251221011847	Walker A/P-loop; other site
251221011848	ATP binding site [chemical binding]; other site
251221011849	Q-loop/lid; other site
251221011850	ABC transporter signature motif; other site
251221011851	Walker B; other site
251221011852	D-loop; other site
251221011853	H-loop/switch region; other site
251221011854	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
251221011855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
251221011856	dimer interface [polypeptide binding]; other site
251221011857	conserved gate region; other site
251221011858	putative PBP binding loops; other site
251221011859	ABC-ATPase subunit interface; other site
251221011860	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
251221011861	membrane-bound complex binding site; other site
251221011862	hinge residues; other site
251221011863	TOBE domain; Region: TOBE; cl01440
251221011864	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
251221011865	Glycoprotease family; Region: Peptidase_M22; pfam00814
251221011866	hypothetical protein; Provisional; Region: PRK06208
251221011867	intersubunit interface [polypeptide binding]; other site
251221011868	active site
251221011869	Zn2+ binding site [ion binding]; other site
251221011870	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
251221011871	Ycf46; Provisional; Region: ycf46; CHL00195
251221011872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
251221011873	Walker A motif; other site
251221011874	ATP binding site [chemical binding]; other site
251221011875	Walker B motif; other site
251221011876	arginine finger; other site
251221011877	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
251221011878	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221011879	putative active site [active]
251221011880	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
251221011881	Ferritin-like domain; Region: Ferritin; pfam00210
251221011882	diiron binding motif [ion binding]; other site
251221011883	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
251221011884	iron-sulfur cluster [ion binding]; other site
251221011885	[2Fe-2S] cluster binding site [ion binding]; other site
251221011886	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221011887	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011888	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
251221011889	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011890	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011891	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011892	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011893	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
251221011894	homoserine dehydrogenase; Provisional; Region: PRK06349
251221011895	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
251221011896	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
251221011897	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
251221011898	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
251221011899	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
251221011900	N-terminal plug; other site
251221011901	ligand-binding site [chemical binding]; other site
251221011902	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
251221011903	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
251221011904	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221011905	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221011906	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221011907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221011908	S-adenosylmethionine binding site [chemical binding]; other site
251221011909	Trm112p-like protein; Region: Trm112p; cl01066
251221011910	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221011911	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221011912	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
251221011913	active site
251221011914	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221011915	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221011916	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
251221011917	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
251221011918	active site
251221011919	Methyltransferase domain; Region: Methyltransf_23; pfam13489
251221011920	Methyltransferase domain; Region: Methyltransf_31; pfam13847
251221011921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221011922	S-adenosylmethionine binding site [chemical binding]; other site
251221011923	Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720
251221011924	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
251221011925	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
251221011926	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
251221011927	Chain length determinant protein; Region: Wzz; pfam02706
251221011928	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
251221011929	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
251221011930	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
251221011931	Magnesium ion binding site [ion binding]; other site
251221011932	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
251221011933	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
251221011934	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
251221011935	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
251221011936	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
251221011937	substrate binding site [chemical binding]; other site
251221011938	glutamase interaction surface [polypeptide binding]; other site
251221011939	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
251221011940	core domain interface [polypeptide binding]; other site
251221011941	delta subunit interface [polypeptide binding]; other site
251221011942	epsilon subunit interface [polypeptide binding]; other site
251221011943	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
251221011944	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
251221011945	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
251221011946	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221011947	FeS/SAM binding site; other site
251221011948	hypothetical protein; Validated; Region: PRK07413
251221011949	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
251221011950	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
251221011951	HEAT repeats; Region: HEAT_2; pfam13646
251221011952	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
251221011953	HEAT-like repeat; Region: HEAT_EZ; pfam13513
251221011954	Transposase domain (DUF772); Region: DUF772; pfam05598
251221011955	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
251221011956	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
251221011957	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
251221011958	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
251221011959	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
251221011960	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
251221011961	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
251221011962	putative active site [active]
251221011963	putative substrate binding site [chemical binding]; other site
251221011964	putative cosubstrate binding site; other site
251221011965	catalytic site [active]
251221011966	cyanophycin synthetase; Provisional; Region: PRK14016
251221011967	ATP-grasp domain; Region: ATP-grasp_4; cl17255
251221011968	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
251221011969	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
251221011970	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
251221011971	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
251221011972	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
251221011973	biotin synthase; Region: bioB; TIGR00433
251221011974	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
251221011975	FeS/SAM binding site; other site
251221011976	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
251221011977	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
251221011978	nudix motif; other site
251221011979	Protein of unknown function (DUF423); Region: DUF423; pfam04241
251221011980	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
251221011981	putative active site [active]
251221011982	putative dimer interface [polypeptide binding]; other site
251221011983	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
251221011984	Transposase; Region: HTH_Tnp_1; cl17663
251221011985	Integrase core domain; Region: rve; pfam00665
251221011986	Integrase core domain; Region: rve_3; pfam13683
251221011987	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
251221011988	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
251221011989	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
251221011990	methionine sulfoxide reductase B; Provisional; Region: PRK00222
251221011991	SOUL heme-binding protein; Region: SOUL; pfam04832
251221011992	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
251221011993	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
251221011994	oligomeric interface; other site
251221011995	putative active site [active]
251221011996	homodimer interface [polypeptide binding]; other site
251221011997	Acyltransferase family; Region: Acyl_transf_3; pfam01757
251221011998	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
251221011999	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
251221012000	C-terminal domain interface [polypeptide binding]; other site
251221012001	GSH binding site (G-site) [chemical binding]; other site
251221012002	dimer interface [polypeptide binding]; other site
251221012003	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
251221012004	dimer interface [polypeptide binding]; other site
251221012005	N-terminal domain interface [polypeptide binding]; other site
251221012006	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221012007	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
251221012008	NAD(P) binding site [chemical binding]; other site
251221012009	active site
251221012010	cell division protein MukB; Provisional; Region: mukB; PRK04863
251221012011	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
251221012012	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
251221012013	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
251221012014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221012015	salt bridge; other site
251221012016	non-specific DNA binding site [nucleotide binding]; other site
251221012017	sequence-specific DNA binding site [nucleotide binding]; other site
251221012018	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221012019	WD domain, G-beta repeat; Region: WD40; pfam00400
251221012020	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221012021	structural tetrad; other site
251221012022	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221012023	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221012024	structural tetrad; other site
251221012025	WD40 repeats; Region: WD40; smart00320
251221012026	Uncharacterized conserved protein [Function unknown]; Region: COG5464
251221012027	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
251221012028	short chain dehydrogenase; Provisional; Region: PRK06125
251221012029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
251221012030	NAD(P) binding site [chemical binding]; other site
251221012031	active site
251221012032	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221012033	non-specific DNA binding site [nucleotide binding]; other site
251221012034	salt bridge; other site
251221012035	sequence-specific DNA binding site [nucleotide binding]; other site
251221012036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
251221012037	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221012038	structural tetrad; other site
251221012039	FOG: WD40 repeat [General function prediction only]; Region: COG2319
251221012040	WD domain, G-beta repeat; Region: WD40; pfam00400
251221012041	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
251221012042	structural tetrad; other site
251221012043	WD domain, G-beta repeat; Region: WD40; pfam00400
251221012044	RNA polymerase sigma factor; Provisional; Region: PRK12519
251221012045	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221012046	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221012047	DNA binding residues [nucleotide binding]
251221012048	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
251221012049	dimer interface [polypeptide binding]; other site
251221012050	active site
251221012051	Schiff base residues; other site
251221012052	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
251221012053	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
251221012054	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
251221012055	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
251221012056	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
251221012057	DNA binding residues [nucleotide binding]
251221012058	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
251221012059	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221012060	non-specific DNA binding site [nucleotide binding]; other site
251221012061	salt bridge; other site
251221012062	sequence-specific DNA binding site [nucleotide binding]; other site
251221012063	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221012064	S-adenosylmethionine binding site [chemical binding]; other site
251221012065	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
251221012066	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
251221012067	putative RNA binding site [nucleotide binding]; other site
251221012068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
251221012069	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
251221012070	MoaE interaction surface [polypeptide binding]; other site
251221012071	MoeB interaction surface [polypeptide binding]; other site
251221012072	thiocarboxylated glycine; other site
251221012073	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
251221012074	MoaE homodimer interface [polypeptide binding]; other site
251221012075	MoaD interaction [polypeptide binding]; other site
251221012076	active site residues [active]
251221012077	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
251221012078	dimer interface [polypeptide binding]; other site
251221012079	active site
251221012080	glycine-pyridoxal phosphate binding site [chemical binding]; other site
251221012081	folate binding site [chemical binding]; other site
251221012082	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
251221012083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221012084	S-adenosylmethionine binding site [chemical binding]; other site
251221012085	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
251221012086	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
251221012087	C-terminal domain interface [polypeptide binding]; other site
251221012088	GSH binding site (G-site) [chemical binding]; other site
251221012089	dimer interface [polypeptide binding]; other site
251221012090	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
251221012091	N-terminal domain interface [polypeptide binding]; other site
251221012092	putative dimer interface [polypeptide binding]; other site
251221012093	active site
251221012094	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
251221012095	Ferritin-like domain; Region: Ferritin; pfam00210
251221012096	dimanganese center [ion binding]; other site
251221012097	GTPase CgtA; Reviewed; Region: obgE; PRK12299
251221012098	GTP1/OBG; Region: GTP1_OBG; pfam01018
251221012099	Obg GTPase; Region: Obg; cd01898
251221012100	G1 box; other site
251221012101	GTP/Mg2+ binding site [chemical binding]; other site
251221012102	Switch I region; other site
251221012103	G2 box; other site
251221012104	G3 box; other site
251221012105	Switch II region; other site
251221012106	G4 box; other site
251221012107	G5 box; other site
251221012108	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
251221012109	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
251221012110	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
251221012111	Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
251221012112	active site
251221012113	catalytic site [active]
251221012114	metal binding site [ion binding]; metal-binding site
251221012115	Protein of unknown function (DUF760); Region: DUF760; pfam05542
251221012116	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
251221012117	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
251221012118	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
251221012119	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
251221012120	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
251221012121	catalytic residue [active]
251221012122	Heat induced stress protein YflT; Region: YflT; pfam11181
251221012123	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
251221012124	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
251221012125	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
251221012126	Minimal MMP-like domain found in Thermus thermophilus TTHA0227, Acidothermus cellulolyticus ACEL2062 and similar proteins; Region: MMP_TTHA0227_like; cl01577
251221012127	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
251221012128	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
251221012129	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
251221012130	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
251221012131	TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536
251221012132	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
251221012133	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
251221012134	RNA binding surface [nucleotide binding]; other site
251221012135	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
251221012136	active site
251221012137	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
251221012138	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
251221012139	non-specific DNA binding site [nucleotide binding]; other site
251221012140	salt bridge; other site
251221012141	sequence-specific DNA binding site [nucleotide binding]; other site
251221012142	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
251221012143	rod shape-determining protein MreB; Provisional; Region: PRK13927
251221012144	MreB and similar proteins; Region: MreB_like; cd10225
251221012145	nucleotide binding site [chemical binding]; other site
251221012146	Mg binding site [ion binding]; other site
251221012147	putative protofilament interaction site [polypeptide binding]; other site
251221012148	RodZ interaction site [polypeptide binding]; other site
251221012149	rod shape-determining protein MreC; Provisional; Region: PRK13922
251221012150	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
251221012151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
251221012152	S-adenosylmethionine binding site [chemical binding]; other site
251221012153	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
251221012154	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
251221012155	putative active site [active]
251221012156	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
251221012157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221012158	active site
251221012159	phosphorylation site [posttranslational modification]
251221012160	intermolecular recognition site; other site
251221012161	dimerization interface [polypeptide binding]; other site
251221012162	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
251221012163	DNA binding residues [nucleotide binding]
251221012164	dimerization interface [polypeptide binding]; other site
251221012165	HAS barrel domain; Region: HAS-barrel; pfam09378
251221012166	Domain of unknown function DUF87; Region: DUF87; pfam01935
251221012167	AAA-like domain; Region: AAA_10; pfam12846
251221012168	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
251221012169	CGNR zinc finger; Region: zf-CGNR; pfam11706
251221012170	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
251221012171	dimer interface [polypeptide binding]; other site
251221012172	[2Fe-2S] cluster binding site [ion binding]; other site
251221012173	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
251221012174	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
251221012175	TrkA-N domain; Region: TrkA_N; pfam02254
251221012176	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
251221012177	TrkA-N domain; Region: TrkA_N; pfam02254
251221012178	TrkA-C domain; Region: TrkA_C; pfam02080
251221012179	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
251221012180	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221012181	putative active site [active]
251221012182	heme pocket [chemical binding]; other site
251221012183	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
251221012184	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
251221012185	putative active site [active]
251221012186	heme pocket [chemical binding]; other site
251221012187	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
251221012188	dimer interface [polypeptide binding]; other site
251221012189	phosphorylation site [posttranslational modification]
251221012190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
251221012191	ATP binding site [chemical binding]; other site
251221012192	Mg2+ binding site [ion binding]; other site
251221012193	G-X-G motif; other site
251221012194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
251221012195	active site
251221012196	phosphorylation site [posttranslational modification]
251221012197	intermolecular recognition site; other site
251221012198	dimerization interface [polypeptide binding]; other site
251221012199	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
251221012200	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
251221012201	active site
251221012202	ATP binding site [chemical binding]; other site
251221012203	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
251221012204	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
251221012205	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
251221012206	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
251221012207	active site
251221012208	HIGH motif; other site
251221012209	dimer interface [polypeptide binding]; other site
251221012210	KMSKS motif; other site
251221012211	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
251221012212	RNA binding surface [nucleotide binding]; other site
251221012213	Protein of function (DUF2518); Region: DUF2518; pfam10726
251221012214	BolA-like protein; Region: BolA; pfam01722
251221012215	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
251221012216	23S rRNA interface [nucleotide binding]; other site
251221012217	L3 interface [polypeptide binding]; other site
251221012218	ribosomal protein S9; Region: rps9; CHL00079
251221012219	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
251221012220	peptide chain release factor 1; Validated; Region: prfA; PRK00591
251221012221	This domain is found in peptide chain release factors; Region: PCRF; smart00937
251221012222	RF-1 domain; Region: RF-1; pfam00472
251221012223	GTPase Era; Reviewed; Region: era; PRK00089
251221012224	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
251221012225	G1 box; other site
251221012226	GTP/Mg2+ binding site [chemical binding]; other site
251221012227	Switch I region; other site
251221012228	G2 box; other site
251221012229	Switch II region; other site
251221012230	G3 box; other site
251221012231	G4 box; other site
251221012232	G5 box; other site
251221012233	KH domain; Region: KH_2; pfam07650
251221012234	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661
251221012235	PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820
251221012236	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
251221012237	PA/protease or protease-like domain interface [polypeptide binding]; other site
251221012238	metal binding site [ion binding]; metal-binding site
251221012239	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
251221012240	active site
251221012241	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
251221012242	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
251221012243	substrate binding site [chemical binding]; other site
251221012244	catalytic Zn binding site [ion binding]; other site
251221012245	NAD binding site [chemical binding]; other site
251221012246	structural Zn binding site [ion binding]; other site
251221012247	dimer interface [polypeptide binding]; other site
251221012248	Predicted esterase [General function prediction only]; Region: COG0627
251221012249	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
251221012250	Transcriptional regulator [Transcription]; Region: LysR; COG0583
251221012251	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
251221012252	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
251221012253	dimerization interface [polypeptide binding]; other site
251221012254	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
251221012255	dinuclear metal binding motif [ion binding]; other site
251221012256	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
251221012257	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
251221012258	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787