-- dump date   	20140619_103224
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
272568000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
272568000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
272568000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568000004	Walker A motif; other site
272568000005	ATP binding site [chemical binding]; other site
272568000006	Walker B motif; other site
272568000007	arginine finger; other site
272568000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
272568000009	DnaA box-binding interface [nucleotide binding]; other site
272568000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
272568000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
272568000012	putative DNA binding surface [nucleotide binding]; other site
272568000013	dimer interface [polypeptide binding]; other site
272568000014	beta-clamp/clamp loader binding surface; other site
272568000015	beta-clamp/translesion DNA polymerase binding surface; other site
272568000016	recombination protein F; Reviewed; Region: recF; PRK00064
272568000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568000018	Walker A/P-loop; other site
272568000019	ATP binding site [chemical binding]; other site
272568000020	Q-loop/lid; other site
272568000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568000022	ABC transporter signature motif; other site
272568000023	Walker B; other site
272568000024	D-loop; other site
272568000025	H-loop/switch region; other site
272568000026	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
272568000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568000028	ATP binding site [chemical binding]; other site
272568000029	Mg2+ binding site [ion binding]; other site
272568000030	G-X-G motif; other site
272568000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
272568000032	anchoring element; other site
272568000033	dimer interface [polypeptide binding]; other site
272568000034	ATP binding site [chemical binding]; other site
272568000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
272568000036	active site
272568000037	putative metal-binding site [ion binding]; other site
272568000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
272568000039	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
272568000040	phosphoglycolate phosphatase; Provisional; Region: PRK13222
272568000041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568000042	motif II; other site
272568000043	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
272568000044	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
272568000045	Substrate binding site; other site
272568000046	Mg++ binding site; other site
272568000047	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
272568000048	active site
272568000049	substrate binding site [chemical binding]; other site
272568000050	CoA binding site [chemical binding]; other site
272568000051	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
272568000052	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
272568000053	glutaminase active site [active]
272568000054	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
272568000055	dimer interface [polypeptide binding]; other site
272568000056	active site
272568000057	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
272568000058	dimer interface [polypeptide binding]; other site
272568000059	active site
272568000060	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568000061	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
272568000062	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
272568000063	thiS-thiF/thiG interaction site; other site
272568000064	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
272568000065	ThiS interaction site; other site
272568000066	putative active site [active]
272568000067	tetramer interface [polypeptide binding]; other site
272568000068	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
272568000069	thiamine phosphate binding site [chemical binding]; other site
272568000070	active site
272568000071	pyrophosphate binding site [ion binding]; other site
272568000072	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
272568000073	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
272568000074	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
272568000075	ligand binding site [chemical binding]; other site
272568000076	flexible hinge region; other site
272568000077	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
272568000078	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
272568000079	catalytic loop [active]
272568000080	iron binding site [ion binding]; other site
272568000081	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
272568000082	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
272568000083	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
272568000084	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
272568000085	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
272568000086	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
272568000087	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568000088	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568000089	Cytochrome c; Region: Cytochrom_C; pfam00034
272568000090	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
272568000091	Mechanosensitive ion channel; Region: MS_channel; pfam00924
272568000092	amino acid transporter; Region: 2A0306; TIGR00909
272568000093	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
272568000094	active site
272568000095	oxyanion hole [active]
272568000096	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
272568000097	mce related protein; Region: MCE; pfam02470
272568000098	ATP-grasp domain; Region: ATP-grasp_4; cl17255
272568000099	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
272568000100	Transglycosylase SLT domain; Region: SLT_2; pfam13406
272568000101	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568000102	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568000103	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
272568000104	Sporulation related domain; Region: SPOR; pfam05036
272568000105	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
272568000106	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
272568000107	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
272568000108	thymidylate kinase; Validated; Region: tmk; PRK00698
272568000109	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
272568000110	TMP-binding site; other site
272568000111	ATP-binding site [chemical binding]; other site
272568000112	DNA polymerase III subunit delta'; Validated; Region: PRK07471
272568000113	AAA ATPase domain; Region: AAA_16; pfam13191
272568000114	DNA polymerase III subunit delta'; Validated; Region: PRK08485
272568000115	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
272568000116	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
272568000117	active site
272568000118	HIGH motif; other site
272568000119	KMSKS motif; other site
272568000120	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
272568000121	tRNA binding surface [nucleotide binding]; other site
272568000122	anticodon binding site; other site
272568000123	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
272568000124	active site
272568000125	putative hydrolase; Provisional; Region: PRK02113
272568000126	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
272568000127	PrkA family serine protein kinase; Provisional; Region: PRK15455
272568000128	AAA ATPase domain; Region: AAA_16; pfam13191
272568000129	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
272568000130	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
272568000131	metal ion-dependent adhesion site (MIDAS); other site
272568000132	SpoVR family protein; Provisional; Region: PRK11767
272568000133	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
272568000134	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
272568000135	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
272568000136	Cytochrome c; Region: Cytochrom_C; pfam00034
272568000137	Cytochrome c; Region: Cytochrom_C; cl11414
272568000138	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
272568000139	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
272568000140	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
272568000141	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
272568000142	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
272568000143	active site
272568000144	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
272568000145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568000146	S-adenosylmethionine binding site [chemical binding]; other site
272568000147	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
272568000148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
272568000149	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568000150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568000151	active site
272568000152	phosphorylation site [posttranslational modification]
272568000153	intermolecular recognition site; other site
272568000154	dimerization interface [polypeptide binding]; other site
272568000155	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568000156	DNA binding site [nucleotide binding]
272568000157	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
272568000158	putative catalytic site [active]
272568000159	putative phosphate binding site [ion binding]; other site
272568000160	active site
272568000161	metal binding site A [ion binding]; metal-binding site
272568000162	DNA binding site [nucleotide binding]
272568000163	putative AP binding site [nucleotide binding]; other site
272568000164	putative metal binding site B [ion binding]; other site
272568000165	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
272568000166	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
272568000167	GIY-YIG motif/motif A; other site
272568000168	active site
272568000169	catalytic site [active]
272568000170	putative DNA binding site [nucleotide binding]; other site
272568000171	metal binding site [ion binding]; metal-binding site
272568000172	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
272568000173	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
272568000174	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
272568000175	MoaE interaction surface [polypeptide binding]; other site
272568000176	MoeB interaction surface [polypeptide binding]; other site
272568000177	thiocarboxylated glycine; other site
272568000178	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
272568000179	MoaE homodimer interface [polypeptide binding]; other site
272568000180	MoaD interaction [polypeptide binding]; other site
272568000181	active site residues [active]
272568000182	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
272568000183	Class I ribonucleotide reductase; Region: RNR_I; cd01679
272568000184	active site
272568000185	dimer interface [polypeptide binding]; other site
272568000186	catalytic residues [active]
272568000187	effector binding site; other site
272568000188	R2 peptide binding site; other site
272568000189	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
272568000190	dimer interface [polypeptide binding]; other site
272568000191	putative radical transfer pathway; other site
272568000192	diiron center [ion binding]; other site
272568000193	tyrosyl radical; other site
272568000194	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
272568000195	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
272568000196	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
272568000197	substrate binding pocket [chemical binding]; other site
272568000198	chain length determination region; other site
272568000199	substrate-Mg2+ binding site; other site
272568000200	catalytic residues [active]
272568000201	aspartate-rich region 1; other site
272568000202	active site lid residues [active]
272568000203	aspartate-rich region 2; other site
272568000204	glutamate racemase; Provisional; Region: PRK00865
272568000205	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
272568000206	active site
272568000207	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
272568000208	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
272568000209	dimer interface [polypeptide binding]; other site
272568000210	active site
272568000211	citrylCoA binding site [chemical binding]; other site
272568000212	NADH binding [chemical binding]; other site
272568000213	cationic pore residues; other site
272568000214	oxalacetate/citrate binding site [chemical binding]; other site
272568000215	coenzyme A binding site [chemical binding]; other site
272568000216	catalytic triad [active]
272568000217	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
272568000218	catalytic core [active]
272568000219	chorismate mutase; Provisional; Region: PRK09239
272568000220	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
272568000221	active site
272568000222	metal binding site [ion binding]; metal-binding site
272568000223	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
272568000224	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
272568000225	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
272568000226	AAA domain; Region: AAA_23; pfam13476
272568000227	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
272568000228	Walker A/P-loop; other site
272568000229	ATP binding site [chemical binding]; other site
272568000230	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
272568000231	ABC transporter signature motif; other site
272568000232	Walker B; other site
272568000233	D-loop; other site
272568000234	H-loop/switch region; other site
272568000235	Thioredoxin; Region: Thioredoxin_4; pfam13462
272568000236	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
272568000237	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
272568000238	Sodium Bile acid symporter family; Region: SBF; cl17470
272568000239	FOG: CBS domain [General function prediction only]; Region: COG0517
272568000240	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
272568000241	Transporter associated domain; Region: CorC_HlyC; smart01091
272568000242	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
272568000243	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
272568000244	PhoH-like protein; Region: PhoH; pfam02562
272568000245	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
272568000246	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
272568000247	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568000248	FeS/SAM binding site; other site
272568000249	TRAM domain; Region: TRAM; cl01282
272568000250	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
272568000251	Surface antigen; Region: Bac_surface_Ag; pfam01103
272568000252	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
272568000253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568000254	active site
272568000255	phosphorylation site [posttranslational modification]
272568000256	intermolecular recognition site; other site
272568000257	dimerization interface [polypeptide binding]; other site
272568000258	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
272568000259	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
272568000260	Predicted membrane protein [Function unknown]; Region: COG4125
272568000261	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
272568000262	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
272568000263	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
272568000264	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
272568000265	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
272568000266	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
272568000267	substrate binding site [chemical binding]; other site
272568000268	catalytic Zn binding site [ion binding]; other site
272568000269	NAD binding site [chemical binding]; other site
272568000270	structural Zn binding site [ion binding]; other site
272568000271	dimer interface [polypeptide binding]; other site
272568000272	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
272568000273	S-formylglutathione hydrolase; Region: PLN02442
272568000274	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
272568000275	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
272568000276	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
272568000277	active site
272568000278	HIGH motif; other site
272568000279	dimer interface [polypeptide binding]; other site
272568000280	KMSKS motif; other site
272568000281	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
272568000282	argininosuccinate synthase; Provisional; Region: PRK13820
272568000283	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
272568000284	ANP binding site [chemical binding]; other site
272568000285	Substrate Binding Site II [chemical binding]; other site
272568000286	Substrate Binding Site I [chemical binding]; other site
272568000287	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
272568000288	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568000289	FeS/SAM binding site; other site
272568000290	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
272568000291	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
272568000292	RNA binding surface [nucleotide binding]; other site
272568000293	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568000294	S-adenosylmethionine binding site [chemical binding]; other site
272568000295	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
272568000296	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
272568000297	TPP-binding site; other site
272568000298	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
272568000299	PYR/PP interface [polypeptide binding]; other site
272568000300	dimer interface [polypeptide binding]; other site
272568000301	TPP binding site [chemical binding]; other site
272568000302	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
272568000303	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
272568000304	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
272568000305	substrate binding pocket [chemical binding]; other site
272568000306	chain length determination region; other site
272568000307	substrate-Mg2+ binding site; other site
272568000308	catalytic residues [active]
272568000309	aspartate-rich region 1; other site
272568000310	active site lid residues [active]
272568000311	aspartate-rich region 2; other site
272568000312	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
272568000313	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
272568000314	CPxP  motif; other site
272568000315	fructokinase; Reviewed; Region: PRK09557
272568000316	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
272568000317	nucleotide binding site [chemical binding]; other site
272568000318	Acetokinase family; Region: Acetate_kinase; cl17229
272568000319	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
272568000320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568000321	S-adenosylmethionine binding site [chemical binding]; other site
272568000322	exopolyphosphatase; Region: exo_poly_only; TIGR03706
272568000323	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
272568000324	MASE1; Region: MASE1; cl17823
272568000325	PAS fold; Region: PAS; pfam00989
272568000326	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568000327	putative active site [active]
272568000328	heme pocket [chemical binding]; other site
272568000329	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568000330	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568000331	metal binding site [ion binding]; metal-binding site
272568000332	active site
272568000333	I-site; other site
272568000334	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
272568000335	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
272568000336	ligand binding site [chemical binding]; other site
272568000337	NAD binding site [chemical binding]; other site
272568000338	tetramer interface [polypeptide binding]; other site
272568000339	catalytic site [active]
272568000340	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
272568000341	L-serine binding site [chemical binding]; other site
272568000342	ACT domain interface; other site
272568000343	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
272568000344	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
272568000345	active site
272568000346	Cytochrome c; Region: Cytochrom_C; cl11414
272568000347	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
272568000348	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
272568000349	active site
272568000350	prephenate dehydratase; Provisional; Region: PRK11899
272568000351	Prephenate dehydratase; Region: PDT; pfam00800
272568000352	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
272568000353	putative L-Phe binding site [chemical binding]; other site
272568000354	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
272568000355	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
272568000356	dimer interface [polypeptide binding]; other site
272568000357	active site
272568000358	catalytic residue [active]
272568000359	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
272568000360	SmpB-tmRNA interface; other site
272568000361	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
272568000362	DNA-binding site [nucleotide binding]; DNA binding site
272568000363	RNA-binding motif; other site
272568000364	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
272568000365	DNA-binding site [nucleotide binding]; DNA binding site
272568000366	RNA-binding motif; other site
272568000367	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
272568000368	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
272568000369	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
272568000370	generic binding surface II; other site
272568000371	ssDNA binding site; other site
272568000372	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
272568000373	ATP binding site [chemical binding]; other site
272568000374	putative Mg++ binding site [ion binding]; other site
272568000375	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568000376	nucleotide binding region [chemical binding]; other site
272568000377	ATP-binding site [chemical binding]; other site
272568000378	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
272568000379	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
272568000380	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
272568000381	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
272568000382	ATP binding site [chemical binding]; other site
272568000383	putative Mg++ binding site [ion binding]; other site
272568000384	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568000385	nucleotide binding region [chemical binding]; other site
272568000386	ATP-binding site [chemical binding]; other site
272568000387	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
272568000388	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
272568000389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568000390	NAD(P) binding site [chemical binding]; other site
272568000391	active site
272568000392	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
272568000393	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
272568000394	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
272568000395	tyrosine decarboxylase; Region: PLN02880
272568000396	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568000397	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568000398	catalytic residue [active]
272568000399	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
272568000400	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
272568000401	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
272568000402	metal ion-dependent adhesion site (MIDAS); other site
272568000403	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
272568000404	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
272568000405	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
272568000406	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
272568000407	HSP70 interaction site [polypeptide binding]; other site
272568000408	BolA-like protein; Region: BolA; pfam01722
272568000409	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
272568000410	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
272568000411	lipoate-protein ligase B; Provisional; Region: PRK14341
272568000412	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
272568000413	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
272568000414	active site
272568000415	tetramer interface; other site
272568000416	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
272568000417	active site
272568000418	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
272568000419	substrate binding site [chemical binding]; other site
272568000420	metal binding site [ion binding]; metal-binding site
272568000421	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
272568000422	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
272568000423	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568000424	FeS/SAM binding site; other site
272568000425	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
272568000426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568000427	S-adenosylmethionine binding site [chemical binding]; other site
272568000428	comF family protein; Region: comF; TIGR00201
272568000429	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
272568000430	active site
272568000431	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
272568000432	GSH binding site [chemical binding]; other site
272568000433	catalytic residues [active]
272568000434	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
272568000435	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
272568000436	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
272568000437	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
272568000438	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568000439	S-adenosylmethionine binding site [chemical binding]; other site
272568000440	aspartate kinase; Reviewed; Region: PRK06635
272568000441	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
272568000442	putative nucleotide binding site [chemical binding]; other site
272568000443	putative catalytic residues [active]
272568000444	putative Mg ion binding site [ion binding]; other site
272568000445	putative aspartate binding site [chemical binding]; other site
272568000446	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
272568000447	putative allosteric regulatory site; other site
272568000448	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
272568000449	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
272568000450	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
272568000451	FMN binding site [chemical binding]; other site
272568000452	substrate binding site [chemical binding]; other site
272568000453	putative catalytic residue [active]
272568000454	Helix-turn-helix domain; Region: HTH_25; pfam13413
272568000455	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
272568000456	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
272568000457	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
272568000458	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
272568000459	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
272568000460	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
272568000461	dimer interface [polypeptide binding]; other site
272568000462	motif 1; other site
272568000463	active site
272568000464	motif 2; other site
272568000465	motif 3; other site
272568000466	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
272568000467	anticodon binding site; other site
272568000468	peptide chain release factor 1; Validated; Region: prfA; PRK00591
272568000469	This domain is found in peptide chain release factors; Region: PCRF; smart00937
272568000470	RF-1 domain; Region: RF-1; pfam00472
272568000471	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
272568000472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568000473	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
272568000474	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
272568000475	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
272568000476	inhibitor-cofactor binding pocket; inhibition site
272568000477	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568000478	catalytic residue [active]
272568000479	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
272568000480	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
272568000481	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568000482	catalytic residue [active]
272568000483	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
272568000484	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
272568000485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568000486	S-adenosylmethionine binding site [chemical binding]; other site
272568000487	AAA domain; Region: AAA_26; pfam13500
272568000488	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
272568000489	LexA repressor; Validated; Region: PRK00215
272568000490	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
272568000491	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
272568000492	Catalytic site [active]
272568000493	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
272568000494	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
272568000495	dimer interface [polypeptide binding]; other site
272568000496	putative functional site; other site
272568000497	putative MPT binding site; other site
272568000498	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
272568000499	Septum formation initiator; Region: DivIC; cl17659
272568000500	enolase; Provisional; Region: eno; PRK00077
272568000501	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
272568000502	dimer interface [polypeptide binding]; other site
272568000503	metal binding site [ion binding]; metal-binding site
272568000504	substrate binding pocket [chemical binding]; other site
272568000505	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
272568000506	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
272568000507	CTP synthetase; Validated; Region: pyrG; PRK05380
272568000508	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
272568000509	Catalytic site [active]
272568000510	active site
272568000511	UTP binding site [chemical binding]; other site
272568000512	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
272568000513	active site
272568000514	putative oxyanion hole; other site
272568000515	catalytic triad [active]
272568000516	triosephosphate isomerase; Provisional; Region: PRK14565
272568000517	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
272568000518	substrate binding site [chemical binding]; other site
272568000519	dimer interface [polypeptide binding]; other site
272568000520	catalytic triad [active]
272568000521	SurA N-terminal domain; Region: SurA_N_3; cl07813
272568000522	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
272568000523	anthranilate synthase component I; Provisional; Region: PRK13573
272568000524	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
272568000525	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
272568000526	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
272568000527	Glutamine amidotransferase class-I; Region: GATase; pfam00117
272568000528	glutamine binding [chemical binding]; other site
272568000529	catalytic triad [active]
272568000530	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
272568000531	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
272568000532	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
272568000533	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
272568000534	active site
272568000535	ribulose/triose binding site [chemical binding]; other site
272568000536	phosphate binding site [ion binding]; other site
272568000537	substrate (anthranilate) binding pocket [chemical binding]; other site
272568000538	product (indole) binding pocket [chemical binding]; other site
272568000539	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
272568000540	trimer interface [polypeptide binding]; other site
272568000541	dimer interface [polypeptide binding]; other site
272568000542	putative active site [active]
272568000543	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
272568000544	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
272568000545	tetramer interface [polypeptide binding]; other site
272568000546	TPP-binding site [chemical binding]; other site
272568000547	heterodimer interface [polypeptide binding]; other site
272568000548	phosphorylation loop region [posttranslational modification]
272568000549	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
272568000550	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
272568000551	E3 interaction surface; other site
272568000552	lipoyl attachment site [posttranslational modification]; other site
272568000553	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
272568000554	alpha subunit interface [polypeptide binding]; other site
272568000555	TPP binding site [chemical binding]; other site
272568000556	heterodimer interface [polypeptide binding]; other site
272568000557	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
272568000558	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
272568000559	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
272568000560	E3 interaction surface; other site
272568000561	lipoyl attachment site [posttranslational modification]; other site
272568000562	e3 binding domain; Region: E3_binding; pfam02817
272568000563	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
272568000564	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
272568000565	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568000566	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
272568000567	lipoyl synthase; Provisional; Region: PRK05481
272568000568	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568000569	FeS/SAM binding site; other site
272568000570	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
272568000571	putative coenzyme Q binding site [chemical binding]; other site
272568000572	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
272568000573	Transposase, Mutator family; Region: Transposase_mut; pfam00872
272568000574	MULE transposase domain; Region: MULE; pfam10551
272568000575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568000576	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568000577	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568000578	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568000579	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568000580	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568000581	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
272568000582	heme-binding site [chemical binding]; other site
272568000583	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
272568000584	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
272568000585	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
272568000586	dimer interface [polypeptide binding]; other site
272568000587	putative CheW interface [polypeptide binding]; other site
272568000588	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
272568000589	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568000590	N-terminal plug; other site
272568000591	ligand-binding site [chemical binding]; other site
272568000592	Competence-damaged protein; Region: CinA; pfam02464
272568000593	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
272568000594	tetramer interfaces [polypeptide binding]; other site
272568000595	binuclear metal-binding site [ion binding]; other site
272568000596	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
272568000597	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568000598	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568000599	catalytic residue [active]
272568000600	adenylosuccinate lyase; Provisional; Region: PRK07492
272568000601	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
272568000602	tetramer interface [polypeptide binding]; other site
272568000603	active site
272568000604	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
272568000605	NRDE protein; Region: NRDE; cl01315
272568000606	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
272568000607	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
272568000608	ATP binding site [chemical binding]; other site
272568000609	active site
272568000610	substrate binding site [chemical binding]; other site
272568000611	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
272568000612	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
272568000613	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
272568000614	putative active site [active]
272568000615	catalytic triad [active]
272568000616	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
272568000617	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
272568000618	dimerization interface [polypeptide binding]; other site
272568000619	ATP binding site [chemical binding]; other site
272568000620	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
272568000621	dimerization interface [polypeptide binding]; other site
272568000622	ATP binding site [chemical binding]; other site
272568000623	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
272568000624	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
272568000625	putative GSH binding site [chemical binding]; other site
272568000626	catalytic residues [active]
272568000627	hypothetical protein; Reviewed; Region: PRK12497
272568000628	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
272568000629	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
272568000630	putative active site [active]
272568000631	catalytic site [active]
272568000632	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
272568000633	putative active site [active]
272568000634	catalytic site [active]
272568000635	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
272568000636	putative catalytic site [active]
272568000637	putative metal binding site [ion binding]; other site
272568000638	putative phosphate binding site [ion binding]; other site
272568000639	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
272568000640	Domain of unknown function DUF20; Region: UPF0118; pfam01594
272568000641	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
272568000642	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
272568000643	active site residue [active]
272568000644	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
272568000645	active site residue [active]
272568000646	cystathionine beta-lyase; Provisional; Region: PRK05967
272568000647	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568000648	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568000649	catalytic residue [active]
272568000650	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
272568000651	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
272568000652	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
272568000653	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
272568000654	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
272568000655	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568000656	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568000657	non-specific DNA binding site [nucleotide binding]; other site
272568000658	salt bridge; other site
272568000659	sequence-specific DNA binding site [nucleotide binding]; other site
272568000660	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
272568000661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
272568000662	Coenzyme A binding pocket [chemical binding]; other site
272568000663	NmrA-like family; Region: NmrA; pfam05368
272568000664	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
272568000665	NADP binding site [chemical binding]; other site
272568000666	active site
272568000667	regulatory binding site [polypeptide binding]; other site
272568000668	Winged helix-turn helix; Region: HTH_29; pfam13551
272568000669	Winged helix-turn helix; Region: HTH_33; pfam13592
272568000670	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568000671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568000672	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
272568000673	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
272568000674	Predicted transcriptional regulators [Transcription]; Region: COG1695
272568000675	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
272568000676	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
272568000677	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
272568000678	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
272568000679	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
272568000680	Autotransporter beta-domain; Region: Autotransporter; smart00869
272568000681	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
272568000682	MPN+ (JAMM) motif; other site
272568000683	Zinc-binding site [ion binding]; other site
272568000684	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
272568000685	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
272568000686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568000687	motif II; other site
272568000688	DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003
272568000689	RadC-like JAB domain; Region: RadC; pfam04002
272568000690	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
272568000691	Part of AAA domain; Region: AAA_19; pfam13245
272568000692	Family description; Region: UvrD_C_2; pfam13538
272568000693	Methyltransferase domain; Region: Methyltransf_31; pfam13847
272568000694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568000695	S-adenosylmethionine binding site [chemical binding]; other site
272568000696	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
272568000697	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
272568000698	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
272568000699	active site
272568000700	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
272568000701	isocitrate dehydrogenase; Validated; Region: PRK06451
272568000702	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
272568000703	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
272568000704	active site
272568000705	homotetramer interface [polypeptide binding]; other site
272568000706	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
272568000707	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
272568000708	active site
272568000709	catalytic site [active]
272568000710	tetramer interface [polypeptide binding]; other site
272568000711	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
272568000712	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568000713	catalytic residue [active]
272568000714	allantoate amidohydrolase; Reviewed; Region: PRK09290
272568000715	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
272568000716	active site
272568000717	metal binding site [ion binding]; metal-binding site
272568000718	dimer interface [polypeptide binding]; other site
272568000719	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
272568000720	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
272568000721	amidase; Provisional; Region: PRK09201
272568000722	Amidase; Region: Amidase; pfam01425
272568000723	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
272568000724	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
272568000725	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
272568000726	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568000727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568000728	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
272568000729	dimerization interface [polypeptide binding]; other site
272568000730	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
272568000731	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
272568000732	XdhC Rossmann domain; Region: XdhC_C; pfam13478
272568000733	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
272568000734	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
272568000735	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
272568000736	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
272568000737	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
272568000738	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
272568000739	phenylhydantoinase; Validated; Region: PRK08323
272568000740	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
272568000741	tetramer interface [polypeptide binding]; other site
272568000742	active site
272568000743	allantoate amidohydrolase; Reviewed; Region: PRK09290
272568000744	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
272568000745	active site
272568000746	metal binding site [ion binding]; metal-binding site
272568000747	dimer interface [polypeptide binding]; other site
272568000748	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
272568000749	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
272568000750	inhibitor-cofactor binding pocket; inhibition site
272568000751	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568000752	catalytic residue [active]
272568000753	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
272568000754	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
272568000755	Na binding site [ion binding]; other site
272568000756	putative substrate binding site [chemical binding]; other site
272568000757	CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934
272568000758	exopolyphosphatase; Region: exo_poly_only; TIGR03706
272568000759	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
272568000760	polyphosphate kinase; Provisional; Region: PRK05443
272568000761	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
272568000762	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
272568000763	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
272568000764	putative domain interface [polypeptide binding]; other site
272568000765	putative active site [active]
272568000766	catalytic site [active]
272568000767	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
272568000768	putative domain interface [polypeptide binding]; other site
272568000769	putative active site [active]
272568000770	catalytic site [active]
272568000771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
272568000772	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
272568000773	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
272568000774	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
272568000775	dimerization interface [polypeptide binding]; other site
272568000776	putative ATP binding site [chemical binding]; other site
272568000777	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
272568000778	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
272568000779	active site
272568000780	substrate binding site [chemical binding]; other site
272568000781	cosubstrate binding site; other site
272568000782	catalytic site [active]
272568000783	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
272568000784	active site
272568000785	multimer interface [polypeptide binding]; other site
272568000786	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
272568000787	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568000788	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568000789	ABC transporter; Region: ABC_tran_2; pfam12848
272568000790	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568000791	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
272568000792	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
272568000793	multidrug resistance protein MdtN; Provisional; Region: PRK10476
272568000794	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568000795	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568000796	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
272568000797	Domain of unknown function DUF20; Region: UPF0118; pfam01594
272568000798	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
272568000799	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568000800	active site
272568000801	motif I; other site
272568000802	motif II; other site
272568000803	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
272568000804	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
272568000805	inhibitor-cofactor binding pocket; inhibition site
272568000806	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568000807	catalytic residue [active]
272568000808	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
272568000809	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
272568000810	NAD(P) binding site [chemical binding]; other site
272568000811	homodimer interface [polypeptide binding]; other site
272568000812	substrate binding site [chemical binding]; other site
272568000813	active site
272568000814	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
272568000815	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
272568000816	Mg++ binding site [ion binding]; other site
272568000817	putative catalytic motif [active]
272568000818	putative substrate binding site [chemical binding]; other site
272568000819	MarR family; Region: MarR; pfam01047
272568000820	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
272568000821	interface (dimer of trimers) [polypeptide binding]; other site
272568000822	Substrate-binding/catalytic site; other site
272568000823	Zn-binding sites [ion binding]; other site
272568000824	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
272568000825	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568000826	nucleotide binding region [chemical binding]; other site
272568000827	ATP-binding site [chemical binding]; other site
272568000828	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
272568000829	RNA binding surface [nucleotide binding]; other site
272568000830	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
272568000831	4Fe-4S binding domain; Region: Fer4; cl02805
272568000832	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
272568000833	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
272568000834	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
272568000835	Subunit I/III interface [polypeptide binding]; other site
272568000836	Subunit III/IV interface [polypeptide binding]; other site
272568000837	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
272568000838	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
272568000839	D-pathway; other site
272568000840	Putative ubiquinol binding site [chemical binding]; other site
272568000841	Low-spin heme (heme b) binding site [chemical binding]; other site
272568000842	Putative water exit pathway; other site
272568000843	Binuclear center (heme o3/CuB) [ion binding]; other site
272568000844	K-pathway; other site
272568000845	Putative proton exit pathway; other site
272568000846	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
272568000847	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
272568000848	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
272568000849	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
272568000850	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
272568000851	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
272568000852	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
272568000853	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
272568000854	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
272568000855	Trp docking motif [polypeptide binding]; other site
272568000856	cytochrome domain interface [polypeptide binding]; other site
272568000857	active site
272568000858	Cytochrome c; Region: Cytochrom_C; pfam00034
272568000859	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568000860	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568000861	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
272568000862	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
272568000863	NAD-dependent deacetylase; Provisional; Region: PRK00481
272568000864	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
272568000865	putative uracil binding site [chemical binding]; other site
272568000866	putative active site [active]
272568000867	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
272568000868	Predicted integral membrane protein [Function unknown]; Region: COG0392
272568000869	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
272568000870	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
272568000871	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
272568000872	active site
272568000873	nucleotide binding site [chemical binding]; other site
272568000874	HIGH motif; other site
272568000875	KMSKS motif; other site
272568000876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
272568000877	ATP binding site [chemical binding]; other site
272568000878	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
272568000879	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
272568000880	DNA-binding site [nucleotide binding]; DNA binding site
272568000881	RNA-binding motif; other site
272568000882	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
272568000883	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
272568000884	ring oligomerisation interface [polypeptide binding]; other site
272568000885	ATP/Mg binding site [chemical binding]; other site
272568000886	stacking interactions; other site
272568000887	hinge regions; other site
272568000888	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
272568000889	oligomerisation interface [polypeptide binding]; other site
272568000890	mobile loop; other site
272568000891	roof hairpin; other site
272568000892	Usg-like family; Region: Usg; cl11567
272568000893	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
272568000894	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
272568000895	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
272568000896	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
272568000897	Cytochrome c; Region: Cytochrom_C; cl11414
272568000898	cytochrome b; Provisional; Region: CYTB; MTH00145
272568000899	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
272568000900	Qi binding site; other site
272568000901	intrachain domain interface; other site
272568000902	interchain domain interface [polypeptide binding]; other site
272568000903	heme bH binding site [chemical binding]; other site
272568000904	heme bL binding site [chemical binding]; other site
272568000905	Qo binding site; other site
272568000906	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
272568000907	interchain domain interface [polypeptide binding]; other site
272568000908	intrachain domain interface; other site
272568000909	Qi binding site; other site
272568000910	Qo binding site; other site
272568000911	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
272568000912	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
272568000913	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
272568000914	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
272568000915	Walker A/P-loop; other site
272568000916	ATP binding site [chemical binding]; other site
272568000917	Q-loop/lid; other site
272568000918	ABC transporter signature motif; other site
272568000919	Walker B; other site
272568000920	D-loop; other site
272568000921	H-loop/switch region; other site
272568000922	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
272568000923	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
272568000924	ABC-ATPase subunit  interface; other site
272568000925	dimer interface [polypeptide binding]; other site
272568000926	putative PBP binding regions; other site
272568000927	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
272568000928	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
272568000929	putative ligand binding residues [chemical binding]; other site
272568000930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
272568000931	Smr domain; Region: Smr; pfam01713
272568000932	Haem-binding domain; Region: Haem_bd; pfam14376
272568000933	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
272568000934	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
272568000935	DNA methylase; Region: N6_N4_Mtase; pfam01555
272568000936	MltA specific insert domain; Region: MltA; smart00925
272568000937	3D domain; Region: 3D; pfam06725
272568000938	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
272568000939	preprotein translocase subunit SecB; Validated; Region: PRK05751
272568000940	SecA binding site; other site
272568000941	Preprotein binding site; other site
272568000942	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
272568000943	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
272568000944	active site
272568000945	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
272568000946	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
272568000947	domain interfaces; other site
272568000948	active site
272568000949	UGMP family protein; Validated; Region: PRK09604
272568000950	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
272568000951	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
272568000952	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
272568000953	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
272568000954	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
272568000955	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
272568000956	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
272568000957	Nucleoside recognition; Region: Gate; pfam07670
272568000958	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
272568000959	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
272568000960	catalytic residues [active]
272568000961	dimer interface [polypeptide binding]; other site
272568000962	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
272568000963	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
272568000964	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
272568000965	MutS domain I; Region: MutS_I; pfam01624
272568000966	MutS domain II; Region: MutS_II; pfam05188
272568000967	MutS domain III; Region: MutS_III; pfam05192
272568000968	MutS domain V; Region: MutS_V; pfam00488
272568000969	Walker A/P-loop; other site
272568000970	ATP binding site [chemical binding]; other site
272568000971	Q-loop/lid; other site
272568000972	ABC transporter signature motif; other site
272568000973	Walker B; other site
272568000974	D-loop; other site
272568000975	H-loop/switch region; other site
272568000976	PII uridylyl-transferase; Provisional; Region: PRK05092
272568000977	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
272568000978	metal binding triad; other site
272568000979	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
272568000980	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
272568000981	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
272568000982	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568000983	TPR motif; other site
272568000984	binding surface
272568000985	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
272568000986	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
272568000987	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
272568000988	active site
272568000989	Zn binding site [ion binding]; other site
272568000990	Hint domain; Region: Hint_2; pfam13403
272568000991	Major royal jelly protein; Region: MRJP; pfam03022
272568000992	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
272568000993	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
272568000994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568000995	catalytic residue [active]
272568000996	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
272568000997	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
272568000998	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
272568000999	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
272568001000	Tim44-like domain; Region: Tim44; pfam04280
272568001001	Winged helix-turn helix; Region: HTH_29; pfam13551
272568001002	Homeodomain-like domain; Region: HTH_32; pfam13565
272568001003	Winged helix-turn helix; Region: HTH_33; pfam13592
272568001004	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568001005	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
272568001006	transposase/IS protein; Provisional; Region: PRK09183
272568001007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568001008	Walker A motif; other site
272568001009	ATP binding site [chemical binding]; other site
272568001010	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
272568001011	Integrase core domain; Region: rve; pfam00665
272568001012	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
272568001013	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
272568001014	UbiA prenyltransferase family; Region: UbiA; pfam01040
272568001015	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
272568001016	Low-spin heme binding site [chemical binding]; other site
272568001017	D-pathway; other site
272568001018	Binuclear center (active site) [active]
272568001019	K-pathway; other site
272568001020	Putative proton exit pathway; other site
272568001021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568001022	S-adenosylmethionine binding site [chemical binding]; other site
272568001023	glutathione synthetase; Provisional; Region: PRK05246
272568001024	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
272568001025	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
272568001026	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
272568001027	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
272568001028	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
272568001029	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
272568001030	active site
272568001031	catalytic residues [active]
272568001032	excinuclease ABC subunit B; Provisional; Region: PRK05298
272568001033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
272568001034	ATP binding site [chemical binding]; other site
272568001035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568001036	nucleotide binding region [chemical binding]; other site
272568001037	ATP-binding site [chemical binding]; other site
272568001038	Ultra-violet resistance protein B; Region: UvrB; pfam12344
272568001039	exodeoxyribonuclease X; Provisional; Region: PRK07983
272568001040	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
272568001041	active site
272568001042	catalytic site [active]
272568001043	substrate binding site [chemical binding]; other site
272568001044	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
272568001045	ABC1 family; Region: ABC1; cl17513
272568001046	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
272568001047	active site
272568001048	ATP binding site [chemical binding]; other site
272568001049	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; cl17526
272568001050	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
272568001051	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
272568001052	active site
272568001053	Zn binding site [ion binding]; other site
272568001054	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
272568001055	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
272568001056	active site
272568001057	dimer interface [polypeptide binding]; other site
272568001058	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
272568001059	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
272568001060	active site
272568001061	FMN binding site [chemical binding]; other site
272568001062	substrate binding site [chemical binding]; other site
272568001063	3Fe-4S cluster binding site [ion binding]; other site
272568001064	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
272568001065	domain interface; other site
272568001066	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
272568001067	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568001068	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568001069	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
272568001070	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
272568001071	putative NAD(P) binding site [chemical binding]; other site
272568001072	active site
272568001073	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
272568001074	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
272568001075	catalytic site [active]
272568001076	putative active site [active]
272568001077	putative substrate binding site [chemical binding]; other site
272568001078	KpsF/GutQ family protein; Region: kpsF; TIGR00393
272568001079	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
272568001080	putative active site [active]
272568001081	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
272568001082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
272568001083	OstA-like protein; Region: OstA; cl00844
272568001084	OstA-like protein; Region: OstA; cl00844
272568001085	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
272568001086	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
272568001087	Walker A/P-loop; other site
272568001088	ATP binding site [chemical binding]; other site
272568001089	Q-loop/lid; other site
272568001090	ABC transporter signature motif; other site
272568001091	Walker B; other site
272568001092	D-loop; other site
272568001093	H-loop/switch region; other site
272568001094	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
272568001095	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
272568001096	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
272568001097	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
272568001098	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
272568001099	30S subunit binding site; other site
272568001100	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
272568001101	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
272568001102	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
272568001103	putative dimer interface [polypeptide binding]; other site
272568001104	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
272568001105	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
272568001106	Winged helix-turn helix; Region: HTH_29; pfam13551
272568001107	Winged helix-turn helix; Region: HTH_33; pfam13592
272568001108	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568001109	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568001110	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
272568001111	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
272568001112	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
272568001113	active site
272568001114	catalytic residues [active]
272568001115	metal binding site [ion binding]; metal-binding site
272568001116	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
272568001117	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
272568001118	putative active site [active]
272568001119	substrate binding site [chemical binding]; other site
272568001120	putative cosubstrate binding site; other site
272568001121	catalytic site [active]
272568001122	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
272568001123	substrate binding site [chemical binding]; other site
272568001124	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
272568001125	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
272568001126	dimerization interface 3.5A [polypeptide binding]; other site
272568001127	active site
272568001128	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
272568001129	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
272568001130	metal binding site [ion binding]; metal-binding site
272568001131	dimer interface [polypeptide binding]; other site
272568001132	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
272568001133	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
272568001134	trimer interface [polypeptide binding]; other site
272568001135	active site
272568001136	substrate binding site [chemical binding]; other site
272568001137	CoA binding site [chemical binding]; other site
272568001138	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
272568001139	feedback inhibition sensing region; other site
272568001140	homohexameric interface [polypeptide binding]; other site
272568001141	nucleotide binding site [chemical binding]; other site
272568001142	N-acetyl-L-glutamate binding site [chemical binding]; other site
272568001143	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
272568001144	G1 box; other site
272568001145	GTP/Mg2+ binding site [chemical binding]; other site
272568001146	Switch I region; other site
272568001147	G2 box; other site
272568001148	G3 box; other site
272568001149	Switch II region; other site
272568001150	G4 box; other site
272568001151	G5 box; other site
272568001152	membrane protein insertase; Provisional; Region: PRK01318
272568001153	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
272568001154	Haemolytic domain; Region: Haemolytic; pfam01809
272568001155	Ribonuclease P; Region: Ribonuclease_P; pfam00825
272568001156	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
272568001157	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
272568001158	dimer interface [polypeptide binding]; other site
272568001159	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568001160	active site
272568001161	metal binding site [ion binding]; metal-binding site
272568001162	glutathione binding site [chemical binding]; other site
272568001163	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
272568001164	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
272568001165	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
272568001166	active site
272568001167	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
272568001168	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
272568001169	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
272568001170	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
272568001171	trimer interface [polypeptide binding]; other site
272568001172	active site
272568001173	UDP-GlcNAc binding site [chemical binding]; other site
272568001174	lipid binding site [chemical binding]; lipid-binding site
272568001175	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
272568001176	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
272568001177	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
272568001178	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
272568001179	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
272568001180	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
272568001181	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
272568001182	Surface antigen; Region: Bac_surface_Ag; pfam01103
272568001183	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
272568001184	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
272568001185	active site
272568001186	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
272568001187	protein binding site [polypeptide binding]; other site
272568001188	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
272568001189	putative substrate binding region [chemical binding]; other site
272568001190	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
272568001191	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
272568001192	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
272568001193	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
272568001194	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
272568001195	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
272568001196	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
272568001197	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
272568001198	catalytic residue [active]
272568001199	putative FPP diphosphate  binding site; other site
272568001200	putative FPP binding hydrophobic cleft; other site
272568001201	dimer interface [polypeptide binding]; other site
272568001202	putative IPP diphosphate binding site; other site
272568001203	ribosome recycling factor; Reviewed; Region: frr; PRK00083
272568001204	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
272568001205	hinge region; other site
272568001206	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
272568001207	putative nucleotide binding site [chemical binding]; other site
272568001208	uridine monophosphate binding site [chemical binding]; other site
272568001209	homohexameric interface [polypeptide binding]; other site
272568001210	GTPase Era; Reviewed; Region: era; PRK00089
272568001211	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
272568001212	G1 box; other site
272568001213	GTP/Mg2+ binding site [chemical binding]; other site
272568001214	Switch I region; other site
272568001215	G2 box; other site
272568001216	Switch II region; other site
272568001217	G3 box; other site
272568001218	G4 box; other site
272568001219	G5 box; other site
272568001220	KH domain; Region: KH_2; pfam07650
272568001221	G-X-X-G motif; other site
272568001222	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
272568001223	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
272568001224	dimerization interface [polypeptide binding]; other site
272568001225	active site
272568001226	metal binding site [ion binding]; metal-binding site
272568001227	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
272568001228	dsRNA binding site [nucleotide binding]; other site
272568001229	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
272568001230	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
272568001231	Catalytic site [active]
272568001232	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
272568001233	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
272568001234	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
272568001235	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
272568001236	Zn2+ binding site [ion binding]; other site
272568001237	Mg2+ binding site [ion binding]; other site
272568001238	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
272568001239	synthetase active site [active]
272568001240	NTP binding site [chemical binding]; other site
272568001241	metal binding site [ion binding]; metal-binding site
272568001242	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
272568001243	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
272568001244	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
272568001245	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
272568001246	catalytic center binding site [active]
272568001247	ATP binding site [chemical binding]; other site
272568001248	Uncharacterized conserved protein [Function unknown]; Region: COG1432
272568001249	LabA_like proteins; Region: LabA; cd10911
272568001250	putative metal binding site [ion binding]; other site
272568001251	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
272568001252	Fe-S cluster binding site [ion binding]; other site
272568001253	DNA binding site [nucleotide binding]
272568001254	active site
272568001255	malate:quinone oxidoreductase; Validated; Region: PRK05257
272568001256	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
272568001257	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
272568001258	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
272568001259	TMAO/DMSO reductase; Reviewed; Region: PRK05363
272568001260	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
272568001261	Moco binding site; other site
272568001262	metal coordination site [ion binding]; other site
272568001263	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
272568001264	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
272568001265	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
272568001266	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
272568001267	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
272568001268	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
272568001269	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
272568001270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568001271	putative substrate translocation pore; other site
272568001272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568001273	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
272568001274	classical (c) SDRs; Region: SDR_c; cd05233
272568001275	NAD(P) binding site [chemical binding]; other site
272568001276	active site
272568001277	galactonate dehydratase; Provisional; Region: PRK14017
272568001278	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
272568001279	putative active site pocket [active]
272568001280	putative metal binding site [ion binding]; other site
272568001281	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
272568001282	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
272568001283	active site
272568001284	intersubunit interface [polypeptide binding]; other site
272568001285	catalytic residue [active]
272568001286	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
272568001287	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
272568001288	Transcriptional regulator [Transcription]; Region: IclR; COG1414
272568001289	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
272568001290	Bacterial transcriptional regulator; Region: IclR; pfam01614
272568001291	Preprotein translocase subunit; Region: YajC; pfam02699
272568001292	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
272568001293	Protein of unknown function (DUF815); Region: DUF815; pfam05673
272568001294	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
272568001295	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
272568001296	[2Fe-2S] cluster binding site [ion binding]; other site
272568001297	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
272568001298	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
272568001299	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
272568001300	active site
272568001301	8-oxo-dGMP binding site [chemical binding]; other site
272568001302	nudix motif; other site
272568001303	metal binding site [ion binding]; metal-binding site
272568001304	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
272568001305	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
272568001306	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
272568001307	putative MPT binding site; other site
272568001308	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
272568001309	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
272568001310	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
272568001311	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
272568001312	active site
272568001313	DNA binding site [nucleotide binding]
272568001314	Int/Topo IB signature motif; other site
272568001315	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
272568001316	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
272568001317	ADP binding site [chemical binding]; other site
272568001318	magnesium binding site [ion binding]; other site
272568001319	putative shikimate binding site; other site
272568001320	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
272568001321	active site
272568001322	dimer interface [polypeptide binding]; other site
272568001323	metal binding site [ion binding]; metal-binding site
272568001324	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
272568001325	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
272568001326	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
272568001327	ligand binding site [chemical binding]; other site
272568001328	Predicted membrane protein [Function unknown]; Region: COG2246
272568001329	GtrA-like protein; Region: GtrA; pfam04138
272568001330	Putative transcription activator [Transcription]; Region: TenA; COG0819
272568001331	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
272568001332	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
272568001333	motif 1; other site
272568001334	active site
272568001335	motif 2; other site
272568001336	motif 3; other site
272568001337	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
272568001338	DHHA1 domain; Region: DHHA1; pfam02272
272568001339	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
272568001340	active site clefts [active]
272568001341	zinc binding site [ion binding]; other site
272568001342	dimer interface [polypeptide binding]; other site
272568001343	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
272568001344	putative catalytic site [active]
272568001345	putative metal binding site [ion binding]; other site
272568001346	putative phosphate binding site [ion binding]; other site
272568001347	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568001348	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568001349	active site
272568001350	catalytic tetrad [active]
272568001351	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
272568001352	nudix motif; other site
272568001353	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
272568001354	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
272568001355	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
272568001356	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
272568001357	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
272568001358	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
272568001359	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
272568001360	RNA binding surface [nucleotide binding]; other site
272568001361	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
272568001362	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
272568001363	G1 box; other site
272568001364	GTP/Mg2+ binding site [chemical binding]; other site
272568001365	G2 box; other site
272568001366	Switch I region; other site
272568001367	G3 box; other site
272568001368	Switch II region; other site
272568001369	G4 box; other site
272568001370	G5 box; other site
272568001371	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
272568001372	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
272568001373	cation binding site [ion binding]; other site
272568001374	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
272568001375	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
272568001376	active site
272568001377	HIGH motif; other site
272568001378	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
272568001379	KMSKS motif; other site
272568001380	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
272568001381	tRNA binding surface [nucleotide binding]; other site
272568001382	anticodon binding site; other site
272568001383	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
272568001384	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
272568001385	putative ssRNA endonuclease; Provisional; Region: PRK11558
272568001386	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
272568001387	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
272568001388	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
272568001389	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
272568001390	CT1975-like protein; Region: Cas_CT1975; pfam09344
272568001391	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
272568001392	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
272568001393	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
272568001394	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
272568001395	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
272568001396	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
272568001397	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
272568001398	active site
272568001399	HIGH motif; other site
272568001400	nucleotide binding site [chemical binding]; other site
272568001401	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
272568001402	active site
272568001403	KMSKS motif; other site
272568001404	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
272568001405	active site
272568001406	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
272568001407	glutathione reductase; Validated; Region: PRK06116
272568001408	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568001409	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
272568001410	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
272568001411	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
272568001412	FAD binding pocket [chemical binding]; other site
272568001413	FAD binding motif [chemical binding]; other site
272568001414	phosphate binding motif [ion binding]; other site
272568001415	beta-alpha-beta structure motif; other site
272568001416	NAD binding pocket [chemical binding]; other site
272568001417	DEAD-like helicases superfamily; Region: DEXDc; smart00487
272568001418	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
272568001419	ATP binding site [chemical binding]; other site
272568001420	putative Mg++ binding site [ion binding]; other site
272568001421	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568001422	nucleotide binding region [chemical binding]; other site
272568001423	ATP-binding site [chemical binding]; other site
272568001424	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
272568001425	seryl-tRNA synthetase; Provisional; Region: PRK05431
272568001426	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
272568001427	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
272568001428	dimer interface [polypeptide binding]; other site
272568001429	active site
272568001430	motif 1; other site
272568001431	motif 2; other site
272568001432	motif 3; other site
272568001433	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
272568001434	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
272568001435	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
272568001436	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
272568001437	Sporulation related domain; Region: SPOR; pfam05036
272568001438	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
272568001439	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
272568001440	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
272568001441	active site
272568001442	HIGH motif; other site
272568001443	nucleotide binding site [chemical binding]; other site
272568001444	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
272568001445	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
272568001446	KMSK motif region; other site
272568001447	tRNA binding surface [nucleotide binding]; other site
272568001448	DALR anticodon binding domain; Region: DALR_1; smart00836
272568001449	anticodon binding site; other site
272568001450	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
272568001451	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
272568001452	Zn2+ binding site [ion binding]; other site
272568001453	Mg2+ binding site [ion binding]; other site
272568001454	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
272568001455	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
272568001456	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
272568001457	putative catalytic site [active]
272568001458	putative phosphate binding site [ion binding]; other site
272568001459	active site
272568001460	metal binding site A [ion binding]; metal-binding site
272568001461	DNA binding site [nucleotide binding]
272568001462	putative AP binding site [nucleotide binding]; other site
272568001463	putative metal binding site B [ion binding]; other site
272568001464	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
272568001465	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
272568001466	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
272568001467	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
272568001468	dimer interface [polypeptide binding]; other site
272568001469	anticodon binding site; other site
272568001470	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
272568001471	homodimer interface [polypeptide binding]; other site
272568001472	motif 1; other site
272568001473	active site
272568001474	motif 2; other site
272568001475	GAD domain; Region: GAD; pfam02938
272568001476	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
272568001477	active site
272568001478	motif 3; other site
272568001479	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
272568001480	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
272568001481	heat shock protein 90; Provisional; Region: PRK05218
272568001482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568001483	ATP binding site [chemical binding]; other site
272568001484	Mg2+ binding site [ion binding]; other site
272568001485	G-X-G motif; other site
272568001486	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
272568001487	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
272568001488	nudix motif; other site
272568001489	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
272568001490	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
272568001491	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
272568001492	heme-binding site [chemical binding]; other site
272568001493	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568001494	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568001495	metal binding site [ion binding]; metal-binding site
272568001496	active site
272568001497	I-site; other site
272568001498	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
272568001499	Peptidase family M50; Region: Peptidase_M50; pfam02163
272568001500	active site
272568001501	putative substrate binding region [chemical binding]; other site
272568001502	FOG: CBS domain [General function prediction only]; Region: COG0517
272568001503	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
272568001504	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568001505	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568001506	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
272568001507	putative substrate binding pocket [chemical binding]; other site
272568001508	putative dimerization interface [polypeptide binding]; other site
272568001509	MobA/MobL family; Region: MobA_MobL; pfam03389
272568001510	multiple promoter invertase; Provisional; Region: mpi; PRK13413
272568001511	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
272568001512	catalytic residues [active]
272568001513	catalytic nucleophile [active]
272568001514	Presynaptic Site I dimer interface [polypeptide binding]; other site
272568001515	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
272568001516	Synaptic Flat tetramer interface [polypeptide binding]; other site
272568001517	Synaptic Site I dimer interface [polypeptide binding]; other site
272568001518	DNA binding site [nucleotide binding]
272568001519	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
272568001520	DNA-binding interface [nucleotide binding]; DNA binding site
272568001521	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
272568001522	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568001523	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568001524	non-specific DNA binding site [nucleotide binding]; other site
272568001525	salt bridge; other site
272568001526	sequence-specific DNA binding site [nucleotide binding]; other site
272568001527	Domain of unknown function (DUF955); Region: DUF955; pfam06114
272568001528	Helix-turn-helix domain; Region: HTH_17; pfam12728
272568001529	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
272568001530	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
272568001531	active site
272568001532	DNA binding site [nucleotide binding]
272568001533	Int/Topo IB signature motif; other site
272568001534	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
272568001535	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
272568001536	RNA binding surface [nucleotide binding]; other site
272568001537	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
272568001538	active site
272568001539	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
272568001540	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
272568001541	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
272568001542	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
272568001543	DNA binding residues [nucleotide binding]
272568001544	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
272568001545	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
272568001546	GDP-binding site [chemical binding]; other site
272568001547	ACT binding site; other site
272568001548	IMP binding site; other site
272568001549	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
272568001550	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
272568001551	dimer interface [polypeptide binding]; other site
272568001552	motif 1; other site
272568001553	active site
272568001554	motif 2; other site
272568001555	motif 3; other site
272568001556	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
272568001557	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568001558	catalytic residue [active]
272568001559	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
272568001560	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
272568001561	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
272568001562	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
272568001563	homodimer interface [polypeptide binding]; other site
272568001564	metal binding site [ion binding]; metal-binding site
272568001565	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
272568001566	homodimer interface [polypeptide binding]; other site
272568001567	active site
272568001568	putative chemical substrate binding site [chemical binding]; other site
272568001569	metal binding site [ion binding]; metal-binding site
272568001570	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
272568001571	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
272568001572	active site
272568001573	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
272568001574	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
272568001575	HflX GTPase family; Region: HflX; cd01878
272568001576	G1 box; other site
272568001577	GTP/Mg2+ binding site [chemical binding]; other site
272568001578	Switch I region; other site
272568001579	G2 box; other site
272568001580	G3 box; other site
272568001581	Switch II region; other site
272568001582	G4 box; other site
272568001583	G5 box; other site
272568001584	bacterial Hfq-like; Region: Hfq; cd01716
272568001585	hexamer interface [polypeptide binding]; other site
272568001586	Sm1 motif; other site
272568001587	RNA binding site [nucleotide binding]; other site
272568001588	Sm2 motif; other site
272568001589	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
272568001590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568001591	active site
272568001592	phosphorylation site [posttranslational modification]
272568001593	intermolecular recognition site; other site
272568001594	dimerization interface [polypeptide binding]; other site
272568001595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568001596	Walker A motif; other site
272568001597	ATP binding site [chemical binding]; other site
272568001598	Walker B motif; other site
272568001599	arginine finger; other site
272568001600	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
272568001601	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
272568001602	dimerization interface [polypeptide binding]; other site
272568001603	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
272568001604	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568001605	dimer interface [polypeptide binding]; other site
272568001606	phosphorylation site [posttranslational modification]
272568001607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568001608	ATP binding site [chemical binding]; other site
272568001609	Mg2+ binding site [ion binding]; other site
272568001610	G-X-G motif; other site
272568001611	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
272568001612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568001613	active site
272568001614	phosphorylation site [posttranslational modification]
272568001615	intermolecular recognition site; other site
272568001616	dimerization interface [polypeptide binding]; other site
272568001617	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568001618	Walker A motif; other site
272568001619	ATP binding site [chemical binding]; other site
272568001620	Walker B motif; other site
272568001621	arginine finger; other site
272568001622	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
272568001623	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
272568001624	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568001625	putative active site [active]
272568001626	heme pocket [chemical binding]; other site
272568001627	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568001628	dimer interface [polypeptide binding]; other site
272568001629	phosphorylation site [posttranslational modification]
272568001630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568001631	ATP binding site [chemical binding]; other site
272568001632	Mg2+ binding site [ion binding]; other site
272568001633	G-X-G motif; other site
272568001634	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
272568001635	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
272568001636	FMN binding site [chemical binding]; other site
272568001637	active site
272568001638	catalytic residues [active]
272568001639	substrate binding site [chemical binding]; other site
272568001640	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
272568001641	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
272568001642	substrate binding site; other site
272568001643	dimer interface; other site
272568001644	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
272568001645	homotrimer interaction site [polypeptide binding]; other site
272568001646	zinc binding site [ion binding]; other site
272568001647	CDP-binding sites; other site
272568001648	ATP12 chaperone protein; Region: ATP12; pfam07542
272568001649	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
272568001650	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
272568001651	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
272568001652	RNA binding surface [nucleotide binding]; other site
272568001653	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
272568001654	active site
272568001655	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
272568001656	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568001657	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568001658	metal binding site [ion binding]; metal-binding site
272568001659	active site
272568001660	I-site; other site
272568001661	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568001662	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568001663	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568001664	recombination factor protein RarA; Reviewed; Region: PRK13342
272568001665	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568001666	Walker A motif; other site
272568001667	ATP binding site [chemical binding]; other site
272568001668	Walker B motif; other site
272568001669	arginine finger; other site
272568001670	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
272568001671	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
272568001672	short chain dehydrogenase; Provisional; Region: PRK07454
272568001673	NADP binding site [chemical binding]; other site
272568001674	substrate binding site [chemical binding]; other site
272568001675	active site
272568001676	HI0933-like protein; Region: HI0933_like; pfam03486
272568001677	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
272568001678	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
272568001679	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
272568001680	C-terminal domain interface [polypeptide binding]; other site
272568001681	GSH binding site (G-site) [chemical binding]; other site
272568001682	dimer interface [polypeptide binding]; other site
272568001683	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
272568001684	N-terminal domain interface [polypeptide binding]; other site
272568001685	dimer interface [polypeptide binding]; other site
272568001686	substrate binding pocket (H-site) [chemical binding]; other site
272568001687	septum formation inhibitor; Reviewed; Region: minC; PRK05177
272568001688	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
272568001689	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
272568001690	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
272568001691	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
272568001692	Switch I; other site
272568001693	Switch II; other site
272568001694	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
272568001695	Transcriptional regulators [Transcription]; Region: GntR; COG1802
272568001696	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568001697	DNA-binding site [nucleotide binding]; DNA binding site
272568001698	FCD domain; Region: FCD; pfam07729
272568001699	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
272568001700	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
272568001701	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568001702	Walker A/P-loop; other site
272568001703	ATP binding site [chemical binding]; other site
272568001704	Q-loop/lid; other site
272568001705	ABC transporter signature motif; other site
272568001706	Walker B; other site
272568001707	D-loop; other site
272568001708	H-loop/switch region; other site
272568001709	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568001710	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
272568001711	putative ADP-binding pocket [chemical binding]; other site
272568001712	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
272568001713	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
272568001714	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
272568001715	Probable Catalytic site; other site
272568001716	metal-binding site
272568001717	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
272568001718	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
272568001719	pantothenate kinase; Provisional; Region: PRK05439
272568001720	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
272568001721	ATP-binding site [chemical binding]; other site
272568001722	CoA-binding site [chemical binding]; other site
272568001723	Mg2+-binding site [ion binding]; other site
272568001724	recombinase A; Provisional; Region: recA; PRK09354
272568001725	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
272568001726	hexamer interface [polypeptide binding]; other site
272568001727	Walker A motif; other site
272568001728	ATP binding site [chemical binding]; other site
272568001729	Walker B motif; other site
272568001730	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
272568001731	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568001732	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
272568001733	5-aminolevulinate synthase; Validated; Region: PRK09064
272568001734	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568001735	catalytic residue [active]
272568001736	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
272568001737	TPP-binding site [chemical binding]; other site
272568001738	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
272568001739	PYR/PP interface [polypeptide binding]; other site
272568001740	dimer interface [polypeptide binding]; other site
272568001741	TPP binding site [chemical binding]; other site
272568001742	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
272568001743	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
272568001744	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
272568001745	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
272568001746	Phosphoglycerate kinase; Region: PGK; pfam00162
272568001747	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
272568001748	substrate binding site [chemical binding]; other site
272568001749	hinge regions; other site
272568001750	ADP binding site [chemical binding]; other site
272568001751	catalytic site [active]
272568001752	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
272568001753	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
272568001754	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
272568001755	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
272568001756	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
272568001757	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568001758	FeS/SAM binding site; other site
272568001759	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
272568001760	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
272568001761	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
272568001762	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568001763	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
272568001764	dimer interface [polypeptide binding]; other site
272568001765	active site
272568001766	metal binding site [ion binding]; metal-binding site
272568001767	glutathione binding site [chemical binding]; other site
272568001768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
272568001769	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
272568001770	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
272568001771	Walker A/P-loop; other site
272568001772	ATP binding site [chemical binding]; other site
272568001773	Q-loop/lid; other site
272568001774	ABC transporter signature motif; other site
272568001775	Walker B; other site
272568001776	D-loop; other site
272568001777	H-loop/switch region; other site
272568001778	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
272568001779	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
272568001780	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
272568001781	putative PBP binding regions; other site
272568001782	ABC-ATPase subunit  interface; other site
272568001783	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
272568001784	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
272568001785	intersubunit interface [polypeptide binding]; other site
272568001786	glycine dehydrogenase; Provisional; Region: PRK05367
272568001787	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568001788	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568001789	catalytic residue [active]
272568001790	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
272568001791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568001792	tetramer interface [polypeptide binding]; other site
272568001793	catalytic residue [active]
272568001794	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
272568001795	lipoyl attachment site [posttranslational modification]; other site
272568001796	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
272568001797	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
272568001798	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
272568001799	spermidine synthase; Provisional; Region: PRK00811
272568001800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568001801	S-adenosylmethionine binding site [chemical binding]; other site
272568001802	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
272568001803	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
272568001804	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
272568001805	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
272568001806	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
272568001807	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
272568001808	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
272568001809	dimer interface [polypeptide binding]; other site
272568001810	ssDNA binding site [nucleotide binding]; other site
272568001811	tetramer (dimer of dimers) interface [polypeptide binding]; other site
272568001812	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
272568001813	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
272568001814	CAP-like domain; other site
272568001815	active site
272568001816	primary dimer interface [polypeptide binding]; other site
272568001817	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
272568001818	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
272568001819	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
272568001820	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
272568001821	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
272568001822	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
272568001823	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
272568001824	active site
272568001825	(T/H)XGH motif; other site
272568001826	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
272568001827	active site
272568001828	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
272568001829	active site
272568001830	catalytic residues [active]
272568001831	DNA binding site [nucleotide binding]
272568001832	Int/Topo IB signature motif; other site
272568001833	Virulence-associated protein E; Region: VirE; pfam05272
272568001834	Phage portal protein; Region: Phage_portal; pfam04860
272568001835	Phage-related protein [Function unknown]; Region: COG4695; cl01923
272568001836	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
272568001837	Phage capsid family; Region: Phage_capsid; pfam05065
272568001838	Phage Terminase; Region: Terminase_1; pfam03354
272568001839	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
272568001840	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
272568001841	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
272568001842	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
272568001843	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
272568001844	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
272568001845	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
272568001846	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
272568001847	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
272568001848	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
272568001849	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353
272568001850	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
272568001851	dimer interface [polypeptide binding]; other site
272568001852	motif 1; other site
272568001853	active site
272568001854	motif 2; other site
272568001855	motif 3; other site
272568001856	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
272568001857	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
272568001858	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
272568001859	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
272568001860	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
272568001861	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
272568001862	rod shape-determining protein MreC; Provisional; Region: PRK13922
272568001863	Protein of unknown function (DUF972); Region: DUF972; pfam06156
272568001864	rod shape-determining protein MreC; Region: MreC; pfam04085
272568001865	rod shape-determining protein MreB; Provisional; Region: PRK13927
272568001866	MreB and similar proteins; Region: MreB_like; cd10225
272568001867	nucleotide binding site [chemical binding]; other site
272568001868	Mg binding site [ion binding]; other site
272568001869	putative protofilament interaction site [polypeptide binding]; other site
272568001870	RodZ interaction site [polypeptide binding]; other site
272568001871	2-isopropylmalate synthase; Validated; Region: PRK00915
272568001872	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
272568001873	active site
272568001874	catalytic residues [active]
272568001875	metal binding site [ion binding]; metal-binding site
272568001876	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
272568001877	Chloramphenicol phosphotransferase-like protein; Region: CPT; pfam07931
272568001878	P-loop motif; other site
272568001879	ATP binding site [chemical binding]; other site
272568001880	Chloramphenicol (Cm) binding site [chemical binding]; other site
272568001881	catalytic residue [active]
272568001882	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
272568001883	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
272568001884	active site
272568001885	metal binding site [ion binding]; metal-binding site
272568001886	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
272568001887	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
272568001888	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
272568001889	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
272568001890	HAMP domain; Region: HAMP; pfam00672
272568001891	dimerization interface [polypeptide binding]; other site
272568001892	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
272568001893	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
272568001894	dimer interface [polypeptide binding]; other site
272568001895	putative CheW interface [polypeptide binding]; other site
272568001896	Domain of unknown function DUF87; Region: DUF87; pfam01935
272568001897	HerA helicase [Replication, recombination, and repair]; Region: COG0433
272568001898	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
272568001899	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
272568001900	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568001901	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
272568001902	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568001903	active site
272568001904	serine acetyltransferase; Provisional; Region: cysE; PRK11132
272568001905	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
272568001906	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
272568001907	trimer interface [polypeptide binding]; other site
272568001908	active site
272568001909	substrate binding site [chemical binding]; other site
272568001910	CoA binding site [chemical binding]; other site
272568001911	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
272568001912	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
272568001913	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
272568001914	Nitrogen regulatory protein P-II; Region: P-II; smart00938
272568001915	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
272568001916	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
272568001917	catalytic motif [active]
272568001918	Catalytic residue [active]
272568001919	Aspartyl protease; Region: Asp_protease_2; pfam13650
272568001920	inhibitor binding site; inhibition site
272568001921	catalytic motif [active]
272568001922	Catalytic residue [active]
272568001923	Active site flap [active]
272568001924	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
272568001925	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
272568001926	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
272568001927	active site
272568001928	DNA binding site [nucleotide binding]
272568001929	Int/Topo IB signature motif; other site
272568001930	primosome assembly protein PriA; Validated; Region: PRK05580
272568001931	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
272568001932	ATP binding site [chemical binding]; other site
272568001933	putative Mg++ binding site [ion binding]; other site
272568001934	hydroperoxidase II; Provisional; Region: katE; PRK11249
272568001935	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
272568001936	heme binding pocket [chemical binding]; other site
272568001937	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
272568001938	domain interactions; other site
272568001939	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
272568001940	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
272568001941	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
272568001942	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
272568001943	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
272568001944	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
272568001945	putative ion selectivity filter; other site
272568001946	putative pore gating glutamate residue; other site
272568001947	putative H+/Cl- coupling transport residue; other site
272568001948	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
272568001949	Cytochrome P450; Region: p450; pfam00067
272568001950	FOG: WD40 repeat [General function prediction only]; Region: COG2319
272568001951	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
272568001952	structural tetrad; other site
272568001953	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
272568001954	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
272568001955	P-loop, Walker A motif; other site
272568001956	Base recognition motif; other site
272568001957	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
272568001958	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
272568001959	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568001960	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
272568001961	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
272568001962	putative C-terminal domain interface [polypeptide binding]; other site
272568001963	putative GSH binding site (G-site) [chemical binding]; other site
272568001964	putative dimer interface [polypeptide binding]; other site
272568001965	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
272568001966	putative N-terminal domain interface [polypeptide binding]; other site
272568001967	putative dimer interface [polypeptide binding]; other site
272568001968	putative substrate binding pocket (H-site) [chemical binding]; other site
272568001969	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
272568001970	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
272568001971	Ligand Binding Site [chemical binding]; other site
272568001972	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
272568001973	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
272568001974	catalytic loop [active]
272568001975	iron binding site [ion binding]; other site
272568001976	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
272568001977	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
272568001978	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568001979	catalytic residue [active]
272568001980	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568001981	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568001982	catalytic residue [active]
272568001983	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568001984	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
272568001985	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
272568001986	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
272568001987	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
272568001988	active site
272568001989	HIGH motif; other site
272568001990	dimer interface [polypeptide binding]; other site
272568001991	KMSKS motif; other site
272568001992	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
272568001993	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
272568001994	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
272568001995	iron-sulfur cluster [ion binding]; other site
272568001996	[2Fe-2S] cluster binding site [ion binding]; other site
272568001997	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
272568001998	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
272568001999	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002000	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
272568002001	putative ADP-binding pocket [chemical binding]; other site
272568002002	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
272568002003	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
272568002004	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
272568002005	substrate binding site [chemical binding]; other site
272568002006	hexamer interface [polypeptide binding]; other site
272568002007	metal binding site [ion binding]; metal-binding site
272568002008	NusB family; Region: NusB; pfam01029
272568002009	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
272568002010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568002011	S-adenosylmethionine binding site [chemical binding]; other site
272568002012	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
272568002013	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
272568002014	catalytic residue [active]
272568002015	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
272568002016	potassium uptake protein; Region: kup; TIGR00794
272568002017	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
272568002018	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568002019	FeS/SAM binding site; other site
272568002020	HemN C-terminal domain; Region: HemN_C; pfam06969
272568002021	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
272568002022	active site
272568002023	Protein of unknown function (DUF1489); Region: DUF1489; cl11570
272568002024	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
272568002025	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568002026	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568002027	catalytic residue [active]
272568002028	Sporulation related domain; Region: SPOR; pfam05036
272568002029	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
272568002030	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
272568002031	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
272568002032	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568002033	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568002034	putative substrate translocation pore; other site
272568002035	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
272568002036	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
272568002037	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
272568002038	HIGH motif; other site
272568002039	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
272568002040	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
272568002041	active site
272568002042	KMSKS motif; other site
272568002043	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
272568002044	tRNA binding surface [nucleotide binding]; other site
272568002045	Lipopolysaccharide-assembly; Region: LptE; pfam04390
272568002046	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
272568002047	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
272568002048	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
272568002049	active site
272568002050	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
272568002051	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
272568002052	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
272568002053	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002054	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
272568002055	Enoylreductase; Region: PKS_ER; smart00829
272568002056	NAD(P) binding site [chemical binding]; other site
272568002057	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
272568002058	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
272568002059	NADP binding site [chemical binding]; other site
272568002060	active site
272568002061	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
272568002062	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
272568002063	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
272568002064	substrate-cofactor binding pocket; other site
272568002065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568002066	catalytic residue [active]
272568002067	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
272568002068	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
272568002069	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
272568002070	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002071	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
272568002072	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
272568002073	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002074	Sulfatase; Region: Sulfatase; cl17466
272568002075	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
272568002076	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
272568002077	NAD binding site [chemical binding]; other site
272568002078	homodimer interface [polypeptide binding]; other site
272568002079	active site
272568002080	substrate binding site [chemical binding]; other site
272568002081	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
272568002082	Integrase core domain; Region: rve; pfam00665
272568002083	Transposase; Region: HTH_Tnp_1; pfam01527
272568002084	putative transposase OrfB; Reviewed; Region: PHA02517
272568002085	HTH-like domain; Region: HTH_21; pfam13276
272568002086	Integrase core domain; Region: rve; pfam00665
272568002087	Integrase core domain; Region: rve_3; pfam13683
272568002088	transposase/IS protein; Provisional; Region: PRK09183
272568002089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568002090	Walker A motif; other site
272568002091	ATP binding site [chemical binding]; other site
272568002092	Walker B motif; other site
272568002093	arginine finger; other site
272568002094	Winged helix-turn helix; Region: HTH_29; pfam13551
272568002095	Winged helix-turn helix; Region: HTH_33; pfam13592
272568002096	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568002097	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568002098	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
272568002099	Transposase domain (DUF772); Region: DUF772; pfam05598
272568002100	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568002101	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568002102	Transposase, Mutator family; Region: Transposase_mut; pfam00872
272568002103	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
272568002104	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
272568002105	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
272568002106	DNA-binding interface [nucleotide binding]; DNA binding site
272568002107	Winged helix-turn helix; Region: HTH_29; pfam13551
272568002108	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
272568002109	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568002110	Walker A/P-loop; other site
272568002111	ATP binding site [chemical binding]; other site
272568002112	Q-loop/lid; other site
272568002113	ABC transporter signature motif; other site
272568002114	Walker B; other site
272568002115	D-loop; other site
272568002116	H-loop/switch region; other site
272568002117	ABC-2 type transporter; Region: ABC2_membrane; cl17235
272568002118	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
272568002119	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
272568002120	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002121	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
272568002122	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
272568002123	Inward rectifier potassium channel; Region: IRK; pfam01007
272568002124	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
272568002125	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568002126	putative metal binding site [ion binding]; other site
272568002127	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
272568002128	CHAD domain; Region: CHAD; pfam05235
272568002129	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
272568002130	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568002131	putative DNA binding site [nucleotide binding]; other site
272568002132	putative Zn2+ binding site [ion binding]; other site
272568002133	AsnC family; Region: AsnC_trans_reg; pfam01037
272568002134	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
272568002135	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
272568002136	active site
272568002137	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
272568002138	dimer interface [polypeptide binding]; other site
272568002139	substrate binding site [chemical binding]; other site
272568002140	catalytic residues [active]
272568002141	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
272568002142	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
272568002143	hydroxyglutarate oxidase; Provisional; Region: PRK11728
272568002144	transposase/IS protein; Provisional; Region: PRK09183
272568002145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568002146	Walker A motif; other site
272568002147	ATP binding site [chemical binding]; other site
272568002148	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
272568002149	Integrase core domain; Region: rve; pfam00665
272568002150	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
272568002151	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
272568002152	tetramer interface [polypeptide binding]; other site
272568002153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568002154	catalytic residue [active]
272568002155	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
272568002156	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
272568002157	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
272568002158	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568002159	DNA-binding site [nucleotide binding]; DNA binding site
272568002160	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568002161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568002162	homodimer interface [polypeptide binding]; other site
272568002163	catalytic residue [active]
272568002164	Predicted membrane protein [Function unknown]; Region: COG2860
272568002165	UPF0126 domain; Region: UPF0126; pfam03458
272568002166	UPF0126 domain; Region: UPF0126; pfam03458
272568002167	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
272568002168	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
272568002169	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
272568002170	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
272568002171	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568002172	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
272568002173	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568002174	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
272568002175	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568002176	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
272568002177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568002178	Walker A/P-loop; other site
272568002179	ATP binding site [chemical binding]; other site
272568002180	Q-loop/lid; other site
272568002181	ABC transporter signature motif; other site
272568002182	Walker B; other site
272568002183	D-loop; other site
272568002184	H-loop/switch region; other site
272568002185	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
272568002186	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568002187	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568002188	TM-ABC transporter signature motif; other site
272568002189	Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308
272568002190	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
272568002191	putative ligand binding site [chemical binding]; other site
272568002192	Winged helix-turn helix; Region: HTH_29; pfam13551
272568002193	Integrase core domain; Region: rve; pfam00665
272568002194	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
272568002195	Integrase core domain; Region: rve_3; pfam13683
272568002196	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
272568002197	acetyl-CoA synthetase; Provisional; Region: PRK00174
272568002198	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
272568002199	acyl-activating enzyme (AAE) consensus motif; other site
272568002200	AMP binding site [chemical binding]; other site
272568002201	active site
272568002202	CoA binding site [chemical binding]; other site
272568002203	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568002204	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568002205	non-specific DNA binding site [nucleotide binding]; other site
272568002206	salt bridge; other site
272568002207	sequence-specific DNA binding site [nucleotide binding]; other site
272568002208	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
272568002209	Domain of unknown function (DUF955); Region: DUF955; pfam06114
272568002210	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
272568002211	isocitrate lyase; Provisional; Region: PRK15063
272568002212	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
272568002213	tetramer interface [polypeptide binding]; other site
272568002214	active site
272568002215	Mg2+/Mn2+ binding site [ion binding]; other site
272568002216	malate synthase G; Provisional; Region: PRK02999
272568002217	active site
272568002218	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
272568002219	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
272568002220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
272568002221	Walker A/P-loop; other site
272568002222	ATP binding site [chemical binding]; other site
272568002223	Q-loop/lid; other site
272568002224	ABC transporter signature motif; other site
272568002225	Walker B; other site
272568002226	D-loop; other site
272568002227	H-loop/switch region; other site
272568002228	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151
272568002229	homotrimer interaction site [polypeptide binding]; other site
272568002230	putative active site [active]
272568002231	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
272568002232	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568002233	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
272568002234	FOG: CBS domain [General function prediction only]; Region: COG0517
272568002235	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
272568002236	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
272568002237	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
272568002238	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
272568002239	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
272568002240	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
272568002241	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
272568002242	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
272568002243	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
272568002244	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
272568002245	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
272568002246	4Fe-4S binding domain; Region: Fer4; pfam00037
272568002247	4Fe-4S binding domain; Region: Fer4; pfam00037
272568002248	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
272568002249	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
272568002250	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
272568002251	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
272568002252	catalytic loop [active]
272568002253	iron binding site [ion binding]; other site
272568002254	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
272568002255	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
272568002256	[4Fe-4S] binding site [ion binding]; other site
272568002257	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
272568002258	molybdopterin cofactor binding site; other site
272568002259	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
272568002260	SLBB domain; Region: SLBB; pfam10531
272568002261	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
272568002262	NADH dehydrogenase subunit E; Validated; Region: PRK07539
272568002263	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
272568002264	putative dimer interface [polypeptide binding]; other site
272568002265	[2Fe-2S] cluster binding site [ion binding]; other site
272568002266	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
272568002267	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
272568002268	NADH dehydrogenase subunit D; Validated; Region: PRK06075
272568002269	NADH dehydrogenase subunit B; Validated; Region: PRK06411
272568002270	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
272568002271	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
272568002272	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
272568002273	putative metal binding site [ion binding]; other site
272568002274	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
272568002275	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
272568002276	NAD binding site [chemical binding]; other site
272568002277	substrate binding site [chemical binding]; other site
272568002278	catalytic Zn binding site [ion binding]; other site
272568002279	tetramer interface [polypeptide binding]; other site
272568002280	structural Zn binding site [ion binding]; other site
272568002281	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568002282	DNA-binding site [nucleotide binding]; DNA binding site
272568002283	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
272568002284	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
272568002285	Phosphoesterase family; Region: Phosphoesterase; pfam04185
272568002286	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
272568002287	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
272568002288	Phosphoesterase family; Region: Phosphoesterase; pfam04185
272568002289	Phosphoesterase family; Region: Phosphoesterase; pfam04185
272568002290	Domain of unknown function (DUF756); Region: DUF756; pfam05506
272568002291	Domain of unknown function (DUF756); Region: DUF756; pfam05506
272568002292	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
272568002293	homotrimer interaction site [polypeptide binding]; other site
272568002294	putative active site [active]
272568002295	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
272568002296	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
272568002297	homodimer interface [polypeptide binding]; other site
272568002298	substrate-cofactor binding pocket; other site
272568002299	catalytic residue [active]
272568002300	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
272568002301	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
272568002302	tetramerization interface [polypeptide binding]; other site
272568002303	NAD(P) binding site [chemical binding]; other site
272568002304	catalytic residues [active]
272568002305	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
272568002306	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
272568002307	NADP binding site [chemical binding]; other site
272568002308	dimer interface [polypeptide binding]; other site
272568002309	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
272568002310	active site
272568002311	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
272568002312	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002313	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
272568002314	putative ADP-binding pocket [chemical binding]; other site
272568002315	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
272568002316	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
272568002317	SLBB domain; Region: SLBB; pfam10531
272568002318	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
272568002319	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
272568002320	Bacterial sugar transferase; Region: Bac_transf; pfam02397
272568002321	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
272568002322	Chain length determinant protein; Region: Wzz; pfam02706
272568002323	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
272568002324	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002325	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
272568002326	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002327	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
272568002328	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
272568002329	active site
272568002330	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
272568002331	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
272568002332	active site
272568002333	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
272568002334	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
272568002335	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
272568002336	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
272568002337	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
272568002338	catalytic triad [active]
272568002339	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
272568002340	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
272568002341	active site
272568002342	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
272568002343	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
272568002344	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
272568002345	tetramer interface [polypeptide binding]; other site
272568002346	TPP-binding site [chemical binding]; other site
272568002347	heterodimer interface [polypeptide binding]; other site
272568002348	phosphorylation loop region [posttranslational modification]
272568002349	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
272568002350	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
272568002351	alpha subunit interface [polypeptide binding]; other site
272568002352	TPP binding site [chemical binding]; other site
272568002353	heterodimer interface [polypeptide binding]; other site
272568002354	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
272568002355	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
272568002356	E3 interaction surface; other site
272568002357	lipoyl attachment site [posttranslational modification]; other site
272568002358	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
272568002359	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
272568002360	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
272568002361	hypothetical protein; Validated; Region: PRK08238
272568002362	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
272568002363	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
272568002364	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
272568002365	Na binding site [ion binding]; other site
272568002366	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
272568002367	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
272568002368	dimer interface [polypeptide binding]; other site
272568002369	ADP-ribose binding site [chemical binding]; other site
272568002370	active site
272568002371	nudix motif; other site
272568002372	metal binding site [ion binding]; metal-binding site
272568002373	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
272568002374	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568002375	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
272568002376	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
272568002377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002378	NAD(P) binding site [chemical binding]; other site
272568002379	active site
272568002380	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
272568002381	Amidinotransferase; Region: Amidinotransf; pfam02274
272568002382	metabolite-proton symporter; Region: 2A0106; TIGR00883
272568002383	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
272568002384	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568002385	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
272568002386	active site
272568002387	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
272568002388	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
272568002389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568002390	putative substrate translocation pore; other site
272568002391	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568002392	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
272568002393	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
272568002394	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568002395	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
272568002396	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
272568002397	putative NAD(P) binding site [chemical binding]; other site
272568002398	putative substrate binding site [chemical binding]; other site
272568002399	catalytic Zn binding site [ion binding]; other site
272568002400	structural Zn binding site [ion binding]; other site
272568002401	dimer interface [polypeptide binding]; other site
272568002402	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
272568002403	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
272568002404	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568002405	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568002406	TM-ABC transporter signature motif; other site
272568002407	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
272568002408	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
272568002409	Walker A/P-loop; other site
272568002410	ATP binding site [chemical binding]; other site
272568002411	Q-loop/lid; other site
272568002412	ABC transporter signature motif; other site
272568002413	Walker B; other site
272568002414	D-loop; other site
272568002415	H-loop/switch region; other site
272568002416	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
272568002417	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
272568002418	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
272568002419	putative ligand binding site [chemical binding]; other site
272568002420	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
272568002421	colanic acid exporter; Provisional; Region: PRK10459
272568002422	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
272568002423	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
272568002424	active site
272568002425	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
272568002426	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
272568002427	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
272568002428	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
272568002429	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
272568002430	putative ADP-binding pocket [chemical binding]; other site
272568002431	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002432	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
272568002433	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
272568002434	active site
272568002435	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
272568002436	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
272568002437	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
272568002438	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
272568002439	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
272568002440	Bacterial sugar transferase; Region: Bac_transf; pfam02397
272568002441	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
272568002442	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
272568002443	Chain length determinant protein; Region: Wzz; pfam02706
272568002444	AAA domain; Region: AAA_31; pfam13614
272568002445	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
272568002446	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568002447	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
272568002448	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
272568002449	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
272568002450	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
272568002451	SLBB domain; Region: SLBB; pfam10531
272568002452	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
272568002453	Alpha 1,4-glycosyltransferase conserved region; Region: Gb3_synth; pfam04572
272568002454	General stress protein [General function prediction only]; Region: GsiB; COG3729
272568002455	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
272568002456	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
272568002457	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
272568002458	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
272568002459	active site
272568002460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568002461	S-adenosylmethionine binding site [chemical binding]; other site
272568002462	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568002463	H+ Antiporter protein; Region: 2A0121; TIGR00900
272568002464	putative substrate translocation pore; other site
272568002465	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568002466	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568002467	metal binding site [ion binding]; metal-binding site
272568002468	active site
272568002469	I-site; other site
272568002470	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568002471	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
272568002472	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
272568002473	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
272568002474	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568002475	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568002476	metal binding site [ion binding]; metal-binding site
272568002477	active site
272568002478	I-site; other site
272568002479	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568002480	PRC-barrel domain; Region: PRC; pfam05239
272568002481	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
272568002482	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
272568002483	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
272568002484	THF binding site; other site
272568002485	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
272568002486	substrate binding site [chemical binding]; other site
272568002487	THF binding site; other site
272568002488	zinc-binding site [ion binding]; other site
272568002489	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568002490	dimerization interface [polypeptide binding]; other site
272568002491	putative DNA binding site [nucleotide binding]; other site
272568002492	putative Zn2+ binding site [ion binding]; other site
272568002493	Methyltransferase domain; Region: Methyltransf_31; pfam13847
272568002494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568002495	S-adenosylmethionine binding site [chemical binding]; other site
272568002496	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
272568002497	FAD binding site [chemical binding]; other site
272568002498	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
272568002499	Transcriptional regulators [Transcription]; Region: PurR; COG1609
272568002500	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
272568002501	DNA binding site [nucleotide binding]
272568002502	domain linker motif; other site
272568002503	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
272568002504	putative dimerization interface [polypeptide binding]; other site
272568002505	putative ligand binding site [chemical binding]; other site
272568002506	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568002507	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
272568002508	active site
272568002509	putative cation:proton antiport protein; Provisional; Region: PRK10669
272568002510	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
272568002511	TrkA-N domain; Region: TrkA_N; pfam02254
272568002512	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
272568002513	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
272568002514	active site
272568002515	Zn binding site [ion binding]; other site
272568002516	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002517	short chain dehydrogenase; Validated; Region: PRK07069
272568002518	NAD(P) binding site [chemical binding]; other site
272568002519	active site
272568002520	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
272568002521	IHF dimer interface [polypeptide binding]; other site
272568002522	IHF - DNA interface [nucleotide binding]; other site
272568002523	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
272568002524	GAF domain; Region: GAF_2; pfam13185
272568002525	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568002526	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568002527	metal binding site [ion binding]; metal-binding site
272568002528	active site
272568002529	I-site; other site
272568002530	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
272568002531	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
272568002532	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
272568002533	Cytochrome P450; Region: p450; cl12078
272568002534	Uncharacterized conserved protein [Function unknown]; Region: COG1359
272568002535	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
272568002536	Subunit I/III interface [polypeptide binding]; other site
272568002537	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
272568002538	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
272568002539	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
272568002540	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
272568002541	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568002542	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
272568002543	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
272568002544	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
272568002545	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
272568002546	molybdopterin cofactor binding site; other site
272568002547	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
272568002548	4Fe-4S binding domain; Region: Fer4; cl02805
272568002549	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
272568002550	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
272568002551	heme-binding residues [chemical binding]; other site
272568002552	Cache domain; Region: Cache_1; pfam02743
272568002553	HAMP domain; Region: HAMP; pfam00672
272568002554	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
272568002555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
272568002556	dimer interface [polypeptide binding]; other site
272568002557	putative CheW interface [polypeptide binding]; other site
272568002558	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002559	acetoin reductases; Region: 23BDH; TIGR02415
272568002560	NAD(P) binding site [chemical binding]; other site
272568002561	active site
272568002562	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
272568002563	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
272568002564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002565	NAD(P) binding site [chemical binding]; other site
272568002566	active site
272568002567	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
272568002568	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
272568002569	putative ligand binding site [chemical binding]; other site
272568002570	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568002571	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568002572	TM-ABC transporter signature motif; other site
272568002573	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
272568002574	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
272568002575	Walker A/P-loop; other site
272568002576	ATP binding site [chemical binding]; other site
272568002577	Q-loop/lid; other site
272568002578	ABC transporter signature motif; other site
272568002579	Walker B; other site
272568002580	D-loop; other site
272568002581	H-loop/switch region; other site
272568002582	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
272568002583	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
272568002584	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
272568002585	putative ligand binding site [chemical binding]; other site
272568002586	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568002587	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568002588	TM-ABC transporter signature motif; other site
272568002589	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
272568002590	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
272568002591	Walker A/P-loop; other site
272568002592	ATP binding site [chemical binding]; other site
272568002593	Q-loop/lid; other site
272568002594	ABC transporter signature motif; other site
272568002595	Walker B; other site
272568002596	D-loop; other site
272568002597	H-loop/switch region; other site
272568002598	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
272568002599	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
272568002600	N- and C-terminal domain interface [polypeptide binding]; other site
272568002601	active site
272568002602	MgATP binding site [chemical binding]; other site
272568002603	catalytic site [active]
272568002604	metal binding site [ion binding]; metal-binding site
272568002605	carbohydrate binding site [chemical binding]; other site
272568002606	putative homodimer interface [polypeptide binding]; other site
272568002607	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
272568002608	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
272568002609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
272568002610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568002611	putative PBP binding loops; other site
272568002612	ABC-ATPase subunit interface; other site
272568002613	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
272568002614	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568002615	dimer interface [polypeptide binding]; other site
272568002616	conserved gate region; other site
272568002617	putative PBP binding loops; other site
272568002618	ABC-ATPase subunit interface; other site
272568002619	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
272568002620	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
272568002621	Walker A/P-loop; other site
272568002622	ATP binding site [chemical binding]; other site
272568002623	Q-loop/lid; other site
272568002624	ABC transporter signature motif; other site
272568002625	Walker B; other site
272568002626	D-loop; other site
272568002627	H-loop/switch region; other site
272568002628	TOBE domain; Region: TOBE_2; pfam08402
272568002629	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002630	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
272568002631	NAD(P) binding site [chemical binding]; other site
272568002632	active site
272568002633	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
272568002634	N- and C-terminal domain interface [polypeptide binding]; other site
272568002635	D-xylulose kinase; Region: XylB; TIGR01312
272568002636	active site
272568002637	MgATP binding site [chemical binding]; other site
272568002638	catalytic site [active]
272568002639	metal binding site [ion binding]; metal-binding site
272568002640	xylulose binding site [chemical binding]; other site
272568002641	homodimer interface [polypeptide binding]; other site
272568002642	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
272568002643	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568002644	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568002645	TM-ABC transporter signature motif; other site
272568002646	short chain dehydrogenase; Provisional; Region: PRK07454
272568002647	classical (c) SDRs; Region: SDR_c; cd05233
272568002648	NAD(P) binding site [chemical binding]; other site
272568002649	active site
272568002650	NMT1-like family; Region: NMT1_2; pfam13379
272568002651	NMT1/THI5 like; Region: NMT1; pfam09084
272568002652	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
272568002653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568002654	putative PBP binding loops; other site
272568002655	dimer interface [polypeptide binding]; other site
272568002656	ABC-ATPase subunit interface; other site
272568002657	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
272568002658	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
272568002659	Walker A/P-loop; other site
272568002660	ATP binding site [chemical binding]; other site
272568002661	Q-loop/lid; other site
272568002662	ABC transporter signature motif; other site
272568002663	Walker B; other site
272568002664	D-loop; other site
272568002665	H-loop/switch region; other site
272568002666	serine acetyltransferase; Provisional; Region: cysE; PRK11132
272568002667	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
272568002668	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
272568002669	trimer interface [polypeptide binding]; other site
272568002670	active site
272568002671	substrate binding site [chemical binding]; other site
272568002672	CoA binding site [chemical binding]; other site
272568002673	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
272568002674	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
272568002675	ring oligomerisation interface [polypeptide binding]; other site
272568002676	ATP/Mg binding site [chemical binding]; other site
272568002677	stacking interactions; other site
272568002678	hinge regions; other site
272568002679	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
272568002680	oligomerisation interface [polypeptide binding]; other site
272568002681	mobile loop; other site
272568002682	roof hairpin; other site
272568002683	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
272568002684	dimer interface [polypeptide binding]; other site
272568002685	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
272568002686	decamer (pentamer of dimers) interface [polypeptide binding]; other site
272568002687	catalytic triad [active]
272568002688	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568002689	Serine hydrolase; Region: Ser_hydrolase; pfam06821
272568002690	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
272568002691	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
272568002692	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
272568002693	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568002694	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
272568002695	Walker A/P-loop; other site
272568002696	ATP binding site [chemical binding]; other site
272568002697	Q-loop/lid; other site
272568002698	ABC transporter signature motif; other site
272568002699	Walker B; other site
272568002700	D-loop; other site
272568002701	H-loop/switch region; other site
272568002702	NIL domain; Region: NIL; pfam09383
272568002703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568002704	dimer interface [polypeptide binding]; other site
272568002705	ABC-ATPase subunit interface; other site
272568002706	putative PBP binding loops; other site
272568002707	L-fucose isomerase; Provisional; Region: fucI; PRK10991
272568002708	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
272568002709	hexamer (dimer of trimers) interface [polypeptide binding]; other site
272568002710	trimer interface [polypeptide binding]; other site
272568002711	substrate binding site [chemical binding]; other site
272568002712	Mn binding site [ion binding]; other site
272568002713	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
272568002714	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
272568002715	putative ligand binding site [chemical binding]; other site
272568002716	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568002717	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568002718	TM-ABC transporter signature motif; other site
272568002719	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
272568002720	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
272568002721	Walker A/P-loop; other site
272568002722	ATP binding site [chemical binding]; other site
272568002723	Q-loop/lid; other site
272568002724	ABC transporter signature motif; other site
272568002725	Walker B; other site
272568002726	D-loop; other site
272568002727	H-loop/switch region; other site
272568002728	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
272568002729	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
272568002730	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
272568002731	DNA binding site [nucleotide binding]
272568002732	domain linker motif; other site
272568002733	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
272568002734	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
272568002735	Amidohydrolase; Region: Amidohydro_2; pfam04909
272568002736	active site
272568002737	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
272568002738	short chain dehydrogenase; Provisional; Region: PRK08628
272568002739	classical (c) SDRs; Region: SDR_c; cd05233
272568002740	NAD(P) binding site [chemical binding]; other site
272568002741	active site
272568002742	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
272568002743	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
272568002744	putative active site pocket [active]
272568002745	metal binding site [ion binding]; metal-binding site
272568002746	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
272568002747	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
272568002748	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
272568002749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002750	NAD(P) binding site [chemical binding]; other site
272568002751	active site
272568002752	Transcriptional regulators [Transcription]; Region: FadR; COG2186
272568002753	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568002754	DNA-binding site [nucleotide binding]; DNA binding site
272568002755	FCD domain; Region: FCD; pfam07729
272568002756	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
272568002757	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568002758	putative DNA binding site [nucleotide binding]; other site
272568002759	putative Zn2+ binding site [ion binding]; other site
272568002760	AsnC family; Region: AsnC_trans_reg; pfam01037
272568002761	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
272568002762	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
272568002763	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
272568002764	Glutamate binding site [chemical binding]; other site
272568002765	NAD binding site [chemical binding]; other site
272568002766	catalytic residues [active]
272568002767	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568002768	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568002769	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
272568002770	putative effector binding pocket; other site
272568002771	putative dimerization interface [polypeptide binding]; other site
272568002772	short chain dehydrogenase; Provisional; Region: PRK12937
272568002773	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
272568002774	NADP binding site [chemical binding]; other site
272568002775	homodimer interface [polypeptide binding]; other site
272568002776	active site
272568002777	substrate binding site [chemical binding]; other site
272568002778	MAPEG family; Region: MAPEG; cl09190
272568002779	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
272568002780	classical (c) SDRs; Region: SDR_c; cd05233
272568002781	NAD(P) binding site [chemical binding]; other site
272568002782	active site
272568002783	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
272568002784	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002785	NAD(P) binding site [chemical binding]; other site
272568002786	active site
272568002787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568002788	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
272568002789	NAD(P) binding site [chemical binding]; other site
272568002790	active site
272568002791	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
272568002792	iron-sulfur cluster [ion binding]; other site
272568002793	[2Fe-2S] cluster binding site [ion binding]; other site
272568002794	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
272568002795	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568002796	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568002797	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
272568002798	Ferritin-like domain; Region: Ferritin; pfam00210
272568002799	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
272568002800	dinuclear metal binding motif [ion binding]; other site
272568002801	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
272568002802	Transposase; Region: HTH_Tnp_1; pfam01527
272568002803	putative transposase OrfB; Reviewed; Region: PHA02517
272568002804	HTH-like domain; Region: HTH_21; pfam13276
272568002805	Integrase core domain; Region: rve; pfam00665
272568002806	Integrase core domain; Region: rve_3; pfam13683
272568002807	Winged helix-turn helix; Region: HTH_29; pfam13551
272568002808	Helix-turn-helix domain; Region: HTH_28; pfam13518
272568002809	Integrase core domain; Region: rve; pfam00665
272568002810	Integrase core domain; Region: rve_3; pfam13683
272568002811	Protein of unknown function DUF72; Region: DUF72; pfam01904
272568002812	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
272568002813	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568002814	DNA-binding site [nucleotide binding]; DNA binding site
272568002815	UTRA domain; Region: UTRA; pfam07702
272568002816	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
272568002817	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
272568002818	ligand binding site [chemical binding]; other site
272568002819	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
272568002820	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
272568002821	Walker A/P-loop; other site
272568002822	ATP binding site [chemical binding]; other site
272568002823	Q-loop/lid; other site
272568002824	ABC transporter signature motif; other site
272568002825	Walker B; other site
272568002826	D-loop; other site
272568002827	H-loop/switch region; other site
272568002828	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
272568002829	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
272568002830	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568002831	TM-ABC transporter signature motif; other site
272568002832	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
272568002833	TM-ABC transporter signature motif; other site
272568002834	Isochorismatase family; Region: Isochorismatase; pfam00857
272568002835	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
272568002836	catalytic triad [active]
272568002837	conserved cis-peptide bond; other site
272568002838	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
272568002839	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
272568002840	substrate binding site [chemical binding]; other site
272568002841	ATP binding site [chemical binding]; other site
272568002842	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
272568002843	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
272568002844	hypothetical protein; Provisional; Region: PRK02947
272568002845	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
272568002846	putative active site [active]
272568002847	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
272568002848	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
272568002849	tetramerization interface [polypeptide binding]; other site
272568002850	NAD(P) binding site [chemical binding]; other site
272568002851	catalytic residues [active]
272568002852	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568002853	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
272568002854	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568002855	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
272568002856	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568002857	catalytic residue [active]
272568002858	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568002859	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568002860	N-terminal plug; other site
272568002861	ligand-binding site [chemical binding]; other site
272568002862	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
272568002863	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
272568002864	putative metal binding site [ion binding]; other site
272568002865	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
272568002866	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
272568002867	Walker A/P-loop; other site
272568002868	ATP binding site [chemical binding]; other site
272568002869	Q-loop/lid; other site
272568002870	ABC transporter signature motif; other site
272568002871	Walker B; other site
272568002872	D-loop; other site
272568002873	H-loop/switch region; other site
272568002874	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
272568002875	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
272568002876	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
272568002877	hydroxyglutarate oxidase; Provisional; Region: PRK11728
272568002878	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
272568002879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568002880	dimer interface [polypeptide binding]; other site
272568002881	conserved gate region; other site
272568002882	putative PBP binding loops; other site
272568002883	ABC-ATPase subunit interface; other site
272568002884	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
272568002885	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
272568002886	substrate binding pocket [chemical binding]; other site
272568002887	membrane-bound complex binding site; other site
272568002888	hinge residues; other site
272568002889	dihydrodipicolinate synthase; Region: dapA; TIGR00674
272568002890	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
272568002891	inhibitor site; inhibition site
272568002892	active site
272568002893	dimer interface [polypeptide binding]; other site
272568002894	catalytic residue [active]
272568002895	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
272568002896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568002897	Walker A/P-loop; other site
272568002898	ATP binding site [chemical binding]; other site
272568002899	Q-loop/lid; other site
272568002900	ABC transporter signature motif; other site
272568002901	Walker B; other site
272568002902	D-loop; other site
272568002903	H-loop/switch region; other site
272568002904	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
272568002905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568002906	dimer interface [polypeptide binding]; other site
272568002907	conserved gate region; other site
272568002908	putative PBP binding loops; other site
272568002909	ABC-ATPase subunit interface; other site
272568002910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568002911	dimer interface [polypeptide binding]; other site
272568002912	conserved gate region; other site
272568002913	putative PBP binding loops; other site
272568002914	ABC-ATPase subunit interface; other site
272568002915	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
272568002916	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
272568002917	substrate binding pocket [chemical binding]; other site
272568002918	membrane-bound complex binding site; other site
272568002919	hinge residues; other site
272568002920	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
272568002921	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
272568002922	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
272568002923	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
272568002924	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
272568002925	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
272568002926	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
272568002927	inhibitor site; inhibition site
272568002928	active site
272568002929	dimer interface [polypeptide binding]; other site
272568002930	catalytic residue [active]
272568002931	Transcriptional regulators [Transcription]; Region: GntR; COG1802
272568002932	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568002933	DNA-binding site [nucleotide binding]; DNA binding site
272568002934	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
272568002935	phenylhydantoinase; Validated; Region: PRK08323
272568002936	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
272568002937	tetramer interface [polypeptide binding]; other site
272568002938	active site
272568002939	Winged helix-turn helix; Region: HTH_29; pfam13551
272568002940	Winged helix-turn helix; Region: HTH_33; pfam13592
272568002941	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568002942	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568002943	Winged helix-turn helix; Region: HTH_29; pfam13551
272568002944	Winged helix-turn helix; Region: HTH_33; pfam13592
272568002945	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568002946	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568002947	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568002948	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568002949	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568002950	Transposase; Region: HTH_Tnp_1; pfam01527
272568002951	putative transposase OrfB; Reviewed; Region: PHA02517
272568002952	HTH-like domain; Region: HTH_21; pfam13276
272568002953	Integrase core domain; Region: rve; pfam00665
272568002954	Integrase core domain; Region: rve_3; pfam13683
272568002955	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
272568002956	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
272568002957	Serine hydrolase (FSH1); Region: FSH1; pfam03959
272568002958	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
272568002959	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
272568002960	catalytic residues [active]
272568002961	Helix-turn-helix domain; Region: HTH_20; pfam12840
272568002962	dimerization interface [polypeptide binding]; other site
272568002963	putative DNA binding site [nucleotide binding]; other site
272568002964	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568002965	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568002966	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568002967	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568002968	multidrug efflux protein; Reviewed; Region: PRK09579
272568002969	Protein export membrane protein; Region: SecD_SecF; cl14618
272568002970	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568002971	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568002972	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
272568002973	dimerization interface [polypeptide binding]; other site
272568002974	substrate binding pocket [chemical binding]; other site
272568002975	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
272568002976	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
272568002977	NAD(P) binding site [chemical binding]; other site
272568002978	active site
272568002979	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
272568002980	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
272568002981	potential catalytic triad [active]
272568002982	conserved cys residue [active]
272568002983	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568002984	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568002985	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
272568002986	dimerization interface [polypeptide binding]; other site
272568002987	Domain of unknown function (DUF336); Region: DUF336; pfam03928
272568002988	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568002989	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568002990	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
272568002991	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
272568002992	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568002993	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568002994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568002995	putative substrate translocation pore; other site
272568002996	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568002997	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568002998	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568002999	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
272568003000	dimerization interface [polypeptide binding]; other site
272568003001	substrate binding pocket [chemical binding]; other site
272568003002	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
272568003003	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
272568003004	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
272568003005	VirB7 interaction site; other site
272568003006	conjugal transfer protein TrbF; Provisional; Region: PRK13872
272568003007	conjugal transfer protein TrbL; Provisional; Region: PRK13875
272568003008	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
272568003009	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
272568003010	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
272568003011	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
272568003012	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
272568003013	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
272568003014	Walker A motif; other site
272568003015	ATP binding site [chemical binding]; other site
272568003016	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
272568003017	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
272568003018	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
272568003019	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
272568003020	ATP binding site [chemical binding]; other site
272568003021	Walker A motif; other site
272568003022	hexamer interface [polypeptide binding]; other site
272568003023	Walker B motif; other site
272568003024	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
272568003025	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
272568003026	Walker A motif; other site
272568003027	ATP binding site [chemical binding]; other site
272568003028	Walker B motif; other site
272568003029	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
272568003030	aspartate racemase; Region: asp_race; TIGR00035
272568003031	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
272568003032	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568003033	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
272568003034	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
272568003035	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
272568003036	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568003037	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568003038	catalytic residue [active]
272568003039	Protein of unknown function (DUF736); Region: DUF736; pfam05284
272568003040	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
272568003041	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
272568003042	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
272568003043	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
272568003044	cofactor binding site; other site
272568003045	DNA binding site [nucleotide binding]
272568003046	substrate interaction site [chemical binding]; other site
272568003047	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
272568003048	Replication initiator protein A; Region: RPA; pfam10134
272568003049	Helix-turn-helix domain; Region: HTH_17; pfam12728
272568003050	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
272568003051	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568003052	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568003053	non-specific DNA binding site [nucleotide binding]; other site
272568003054	salt bridge; other site
272568003055	sequence-specific DNA binding site [nucleotide binding]; other site
272568003056	Protein of unknown function (DUF736); Region: DUF736; cl02303
272568003057	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
272568003058	DNA methylase; Region: N6_N4_Mtase; cl17433
272568003059	Cupin; Region: Cupin_6; pfam12852
272568003060	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
272568003061	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568003062	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568003063	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
272568003064	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
272568003065	putative NAD(P) binding site [chemical binding]; other site
272568003066	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
272568003067	AAA domain; Region: AAA_30; pfam13604
272568003068	Family description; Region: UvrD_C_2; pfam13538
272568003069	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
272568003070	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
272568003071	catalytic residues [active]
272568003072	catalytic nucleophile [active]
272568003073	Recombinase; Region: Recombinase; pfam07508
272568003074	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
272568003075	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
272568003076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568003077	NAD(P) binding site [chemical binding]; other site
272568003078	active site
272568003079	Predicted transcriptional regulators [Transcription]; Region: COG1733
272568003080	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
272568003081	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
272568003082	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
272568003083	dimer interface [polypeptide binding]; other site
272568003084	active site
272568003085	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
272568003086	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568003087	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568003088	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568003089	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568003090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568003091	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568003092	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
272568003093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568003094	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
272568003095	dimerization interface [polypeptide binding]; other site
272568003096	substrate binding pocket [chemical binding]; other site
272568003097	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
272568003098	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
272568003099	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
272568003100	VirB7 interaction site; other site
272568003101	conjugal transfer protein TrbF; Provisional; Region: PRK13872
272568003102	conjugal transfer protein TrbL; Provisional; Region: PRK13875
272568003103	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
272568003104	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
272568003105	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
272568003106	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
272568003107	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
272568003108	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
272568003109	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
272568003110	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
272568003111	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
272568003112	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
272568003113	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
272568003114	ATP binding site [chemical binding]; other site
272568003115	Walker A motif; other site
272568003116	hexamer interface [polypeptide binding]; other site
272568003117	Walker B motif; other site
272568003118	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
272568003119	IHF dimer interface [polypeptide binding]; other site
272568003120	IHF - DNA interface [nucleotide binding]; other site
272568003121	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
272568003122	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
272568003123	Protein of unknown function (DUF499); Region: DUF499; pfam04465
272568003124	Protein of unknown function (DUF499); Region: DUF499; pfam04465
272568003125	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
272568003126	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
272568003127	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
272568003128	DEAD-like helicases superfamily; Region: DEXDc; smart00487
272568003129	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
272568003130	ATP binding site [chemical binding]; other site
272568003131	putative Mg++ binding site [ion binding]; other site
272568003132	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
272568003133	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568003134	nucleotide binding region [chemical binding]; other site
272568003135	ATP-binding site [chemical binding]; other site
272568003136	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
272568003137	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
272568003138	putative active site [active]
272568003139	homotetrameric interface [polypeptide binding]; other site
272568003140	metal binding site [ion binding]; metal-binding site
272568003141	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
272568003142	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
272568003143	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
272568003144	Walker A motif; other site
272568003145	ATP binding site [chemical binding]; other site
272568003146	Walker B motif; other site
272568003147	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
272568003148	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
272568003149	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
272568003150	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
272568003151	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568003152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568003153	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568003154	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
272568003155	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568003156	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568003157	catalytic residue [active]
272568003158	Protein of unknown function (DUF736); Region: DUF736; pfam05284
272568003159	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
272568003160	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
272568003161	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
272568003162	ParA-like protein; Provisional; Region: PHA02518
272568003163	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
272568003164	P-loop; other site
272568003165	Magnesium ion binding site [ion binding]; other site
272568003166	Replication initiator protein A; Region: RPA; pfam10134
272568003167	Helix-turn-helix domain; Region: HTH_17; pfam12728
272568003168	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
272568003169	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
272568003170	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
272568003171	Uncharacterized conserved protein [Function unknown]; Region: COG5489
272568003172	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
272568003173	Toprim domain; Region: Toprim_3; pfam13362
272568003174	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
272568003175	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
272568003176	putative active site [active]
272568003177	putative metal binding site [ion binding]; other site
272568003178	oxidoreductase; Provisional; Region: PRK06196
272568003179	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
272568003180	putative NAD(P) binding site [chemical binding]; other site
272568003181	active site
272568003182	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568003183	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568003184	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
272568003185	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
272568003186	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568003187	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568003188	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
272568003189	putative effector binding pocket; other site
272568003190	putative dimerization interface [polypeptide binding]; other site
272568003191	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568003192	short chain dehydrogenase; Provisional; Region: PRK12939
272568003193	NAD(P) binding site [chemical binding]; other site
272568003194	active site
272568003195	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568003196	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568003197	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
272568003198	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
272568003199	transmembrane helices; other site
272568003200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568003201	putative substrate translocation pore; other site
272568003202	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568003203	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
272568003204	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568003205	active site
272568003206	metal binding site [ion binding]; metal-binding site
272568003207	ParB-like nuclease domain; Region: ParBc; pfam02195
272568003208	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
272568003209	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
272568003210	catalytic residues [active]
272568003211	catalytic nucleophile [active]
272568003212	Recombinase; Region: Recombinase; pfam07508
272568003213	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
272568003214	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
272568003215	Mg2+ binding site [ion binding]; other site
272568003216	G-X-G motif; other site
272568003217	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
272568003218	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
272568003219	putative C-terminal domain interface [polypeptide binding]; other site
272568003220	putative GSH binding site (G-site) [chemical binding]; other site
272568003221	putative dimer interface [polypeptide binding]; other site
272568003222	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
272568003223	N-terminal domain interface [polypeptide binding]; other site
272568003224	dimer interface [polypeptide binding]; other site
272568003225	substrate binding pocket (H-site) [chemical binding]; other site
272568003226	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
272568003227	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
272568003228	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
272568003229	trimer interface [polypeptide binding]; other site
272568003230	active site
272568003231	UDP-GlcNAc binding site [chemical binding]; other site
272568003232	lipid binding site [chemical binding]; lipid-binding site
272568003233	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
272568003234	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
272568003235	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568003236	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568003237	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568003238	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
272568003239	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
272568003240	DNA methylase; Region: N6_N4_Mtase; cl17433
272568003241	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
272568003242	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
272568003243	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
272568003244	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
272568003245	catalytic residues [active]
272568003246	catalytic nucleophile [active]
272568003247	Recombinase; Region: Recombinase; pfam07508
272568003248	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
272568003249	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
272568003250	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
272568003251	nucleophile elbow; other site
272568003252	Patatin phospholipase; Region: DUF3734; pfam12536
272568003253	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
272568003254	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
272568003255	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
272568003256	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
272568003257	XdhC Rossmann domain; Region: XdhC_C; pfam13478
272568003258	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
272568003259	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
272568003260	Ligand binding site; other site
272568003261	metal-binding site
272568003262	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
272568003263	homotrimer interaction site [polypeptide binding]; other site
272568003264	putative active site [active]
272568003265	CHAP domain; Region: CHAP; cl17642
272568003266	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
272568003267	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
272568003268	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
272568003269	active site
272568003270	(T/H)XGH motif; other site
272568003271	Oligomerisation domain; Region: Oligomerisation; pfam02410
272568003272	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
272568003273	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
272568003274	putative catalytic cysteine [active]
272568003275	GTP-binding protein YchF; Reviewed; Region: PRK09601
272568003276	YchF GTPase; Region: YchF; cd01900
272568003277	G1 box; other site
272568003278	GTP/Mg2+ binding site [chemical binding]; other site
272568003279	Switch I region; other site
272568003280	G2 box; other site
272568003281	Switch II region; other site
272568003282	G3 box; other site
272568003283	G4 box; other site
272568003284	G5 box; other site
272568003285	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
272568003286	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
272568003287	putative active site [active]
272568003288	catalytic residue [active]
272568003289	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
272568003290	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
272568003291	5S rRNA interface [nucleotide binding]; other site
272568003292	CTC domain interface [polypeptide binding]; other site
272568003293	L16 interface [polypeptide binding]; other site
272568003294	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
272568003295	catalytic core [active]
272568003296	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
272568003297	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
272568003298	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
272568003299	active site
272568003300	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
272568003301	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
272568003302	Uncharacterized conserved protein [Function unknown]; Region: COG1565
272568003303	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
272568003304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568003305	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
272568003306	NAD(P) binding site [chemical binding]; other site
272568003307	active site
272568003308	Membrane fusogenic activity; Region: BMFP; pfam04380
272568003309	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
272568003310	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
272568003311	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
272568003312	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
272568003313	IHF dimer interface [polypeptide binding]; other site
272568003314	IHF - DNA interface [nucleotide binding]; other site
272568003315	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568003316	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
272568003317	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568003318	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
272568003319	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568003320	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
272568003321	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
272568003322	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
272568003323	active site
272568003324	NAD synthetase; Reviewed; Region: nadE; PRK02628
272568003325	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
272568003326	multimer interface [polypeptide binding]; other site
272568003327	active site
272568003328	catalytic triad [active]
272568003329	protein interface 1 [polypeptide binding]; other site
272568003330	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
272568003331	homodimer interface [polypeptide binding]; other site
272568003332	NAD binding pocket [chemical binding]; other site
272568003333	ATP binding pocket [chemical binding]; other site
272568003334	Mg binding site [ion binding]; other site
272568003335	active-site loop [active]
272568003336	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
272568003337	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
272568003338	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
272568003339	active site
272568003340	homotetramer interface [polypeptide binding]; other site
272568003341	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
272568003342	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
272568003343	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
272568003344	mce related protein; Region: MCE; pfam02470
272568003345	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
272568003346	NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534
272568003347	TSCPD domain; Region: TSCPD; pfam12637
272568003348	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
272568003349	homotrimer interaction site [polypeptide binding]; other site
272568003350	putative active site [active]
272568003351	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
272568003352	Protein of unknown function, DUF482; Region: DUF482; pfam04339
272568003353	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
272568003354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
272568003355	SnoaL-like domain; Region: SnoaL_2; pfam12680
272568003356	isocitrate dehydrogenase; Validated; Region: PRK08299
272568003357	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
272568003358	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
272568003359	putative NAD(P) binding site [chemical binding]; other site
272568003360	putative substrate binding site [chemical binding]; other site
272568003361	catalytic Zn binding site [ion binding]; other site
272568003362	structural Zn binding site [ion binding]; other site
272568003363	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
272568003364	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
272568003365	ATP binding site [chemical binding]; other site
272568003366	putative Mg++ binding site [ion binding]; other site
272568003367	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568003368	nucleotide binding region [chemical binding]; other site
272568003369	ATP-binding site [chemical binding]; other site
272568003370	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
272568003371	RNA binding site [nucleotide binding]; other site
272568003372	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
272568003373	classical (c) SDRs; Region: SDR_c; cd05233
272568003374	NAD(P) binding site [chemical binding]; other site
272568003375	active site
272568003376	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
272568003377	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
272568003378	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
272568003379	putative deacylase active site [active]
272568003380	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428
272568003381	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
272568003382	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
272568003383	FAD binding pocket [chemical binding]; other site
272568003384	FAD binding motif [chemical binding]; other site
272568003385	phosphate binding motif [ion binding]; other site
272568003386	NAD binding pocket [chemical binding]; other site
272568003387	Predicted transcriptional regulators [Transcription]; Region: COG1695
272568003388	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
272568003389	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
272568003390	Ligand binding site; other site
272568003391	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
272568003392	DXD motif; other site
272568003393	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
272568003394	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
272568003395	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
272568003396	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
272568003397	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
272568003398	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
272568003399	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
272568003400	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
272568003401	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
272568003402	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
272568003403	protein binding site [polypeptide binding]; other site
272568003404	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
272568003405	protein binding site [polypeptide binding]; other site
272568003406	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
272568003407	active site
272568003408	catalytic triad [active]
272568003409	oxyanion hole [active]
272568003410	OpgC protein; Region: OpgC_C; pfam10129
272568003411	Acyltransferase family; Region: Acyl_transf_3; pfam01757
272568003412	Domain of unknown function DUF59; Region: DUF59; pfam01883
272568003413	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
272568003414	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
272568003415	Walker A motif; other site
272568003416	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
272568003417	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
272568003418	putative metal binding site [ion binding]; other site
272568003419	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
272568003420	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
272568003421	epoxyqueuosine reductase; Region: TIGR00276
272568003422	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
272568003423	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
272568003424	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
272568003425	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
272568003426	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
272568003427	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
272568003428	substrate binding site [chemical binding]; other site
272568003429	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568003430	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568003431	metal binding site [ion binding]; metal-binding site
272568003432	active site
272568003433	I-site; other site
272568003434	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
272568003435	amphipathic channel; other site
272568003436	Asn-Pro-Ala signature motifs; other site
272568003437	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
272568003438	dimer interface [polypeptide binding]; other site
272568003439	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568003440	metal binding site [ion binding]; metal-binding site
272568003441	fumarate hydratase; Provisional; Region: PRK15389
272568003442	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
272568003443	Fumarase C-terminus; Region: Fumerase_C; pfam05683
272568003444	Stringent starvation protein B; Region: SspB; pfam04386
272568003445	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
272568003446	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
272568003447	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
272568003448	MOSC domain; Region: MOSC; pfam03473
272568003449	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
272568003450	active site
272568003451	catalytic residues [active]
272568003452	VacJ like lipoprotein; Region: VacJ; cl01073
272568003453	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
272568003454	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
272568003455	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568003456	active site
272568003457	motif I; other site
272568003458	motif II; other site
272568003459	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568003460	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
272568003461	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
272568003462	quinone interaction residues [chemical binding]; other site
272568003463	active site
272568003464	catalytic residues [active]
272568003465	FMN binding site [chemical binding]; other site
272568003466	substrate binding site [chemical binding]; other site
272568003467	Major royal jelly protein; Region: MRJP; pfam03022
272568003468	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568003469	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568003470	Cytochrome c; Region: Cytochrom_C; pfam00034
272568003471	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
272568003472	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568003473	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
272568003474	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
272568003475	Domain of unknown function (DUF336); Region: DUF336; pfam03928
272568003476	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568003477	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568003478	Cytochrome c; Region: Cytochrom_C; pfam00034
272568003479	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
272568003480	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
272568003481	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
272568003482	fumarate hydratase; Reviewed; Region: fumC; PRK00485
272568003483	Class II fumarases; Region: Fumarase_classII; cd01362
272568003484	active site
272568003485	tetramer interface [polypeptide binding]; other site
272568003486	Pirin-related protein [General function prediction only]; Region: COG1741
272568003487	Pirin; Region: Pirin; pfam02678
272568003488	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568003489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568003490	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
272568003491	putative effector binding pocket; other site
272568003492	dimerization interface [polypeptide binding]; other site
272568003493	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
272568003494	homotrimer interface [polypeptide binding]; other site
272568003495	Walker A motif; other site
272568003496	GTP binding site [chemical binding]; other site
272568003497	Walker B motif; other site
272568003498	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
272568003499	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
272568003500	putative dimer interface [polypeptide binding]; other site
272568003501	active site pocket [active]
272568003502	putative cataytic base [active]
272568003503	cobalamin synthase; Reviewed; Region: cobS; PRK00235
272568003504	CHRD domain; Region: CHRD; pfam07452
272568003505	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
272568003506	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
272568003507	putative acyl-acceptor binding pocket; other site
272568003508	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
272568003509	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
272568003510	Substrate binding site; other site
272568003511	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
272568003512	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
272568003513	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
272568003514	NAD binding site [chemical binding]; other site
272568003515	homodimer interface [polypeptide binding]; other site
272568003516	active site
272568003517	substrate binding site [chemical binding]; other site
272568003518	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
272568003519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568003520	active site
272568003521	phosphorylation site [posttranslational modification]
272568003522	intermolecular recognition site; other site
272568003523	dimerization interface [polypeptide binding]; other site
272568003524	PAS domain S-box; Region: sensory_box; TIGR00229
272568003525	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568003526	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568003527	metal binding site [ion binding]; metal-binding site
272568003528	active site
272568003529	I-site; other site
272568003530	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568003531	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
272568003532	active site
272568003533	DNA polymerase IV; Validated; Region: PRK02406
272568003534	DNA binding site [nucleotide binding]
272568003535	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
272568003536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568003537	putative substrate translocation pore; other site
272568003538	POT family; Region: PTR2; cl17359
272568003539	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
272568003540	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
272568003541	Ferritin-like domain; Region: Ferritin; pfam00210
272568003542	dimerization interface [polypeptide binding]; other site
272568003543	DPS ferroxidase diiron center [ion binding]; other site
272568003544	ion pore; other site
272568003545	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
272568003546	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
272568003547	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
272568003548	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
272568003549	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
272568003550	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
272568003551	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
272568003552	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
272568003553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
272568003554	Coenzyme A binding pocket [chemical binding]; other site
272568003555	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
272568003556	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
272568003557	nucleotide binding site [chemical binding]; other site
272568003558	putative NEF/HSP70 interaction site [polypeptide binding]; other site
272568003559	SBD interface [polypeptide binding]; other site
272568003560	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
272568003561	aldehyde dehydrogenase family 7 member; Region: PLN02315
272568003562	tetrameric interface [polypeptide binding]; other site
272568003563	NAD binding site [chemical binding]; other site
272568003564	catalytic residues [active]
272568003565	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568003566	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568003567	active site
272568003568	phosphorylation site [posttranslational modification]
272568003569	intermolecular recognition site; other site
272568003570	dimerization interface [polypeptide binding]; other site
272568003571	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568003572	DNA binding site [nucleotide binding]
272568003573	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
272568003574	dimer interface [polypeptide binding]; other site
272568003575	substrate binding site [chemical binding]; other site
272568003576	ATP binding site [chemical binding]; other site
272568003577	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
272568003578	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
272568003579	active site
272568003580	substrate binding site [chemical binding]; other site
272568003581	metal binding site [ion binding]; metal-binding site
272568003582	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
272568003583	dihydropteroate synthase; Region: DHPS; TIGR01496
272568003584	substrate binding pocket [chemical binding]; other site
272568003585	dimer interface [polypeptide binding]; other site
272568003586	inhibitor binding site; inhibition site
272568003587	FtsH Extracellular; Region: FtsH_ext; pfam06480
272568003588	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
272568003589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568003590	Walker A motif; other site
272568003591	ATP binding site [chemical binding]; other site
272568003592	Walker B motif; other site
272568003593	arginine finger; other site
272568003594	Peptidase family M41; Region: Peptidase_M41; pfam01434
272568003595	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
272568003596	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
272568003597	Ligand Binding Site [chemical binding]; other site
272568003598	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
272568003599	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
272568003600	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
272568003601	ligand binding site [chemical binding]; other site
272568003602	translocation protein TolB; Provisional; Region: tolB; PRK05137
272568003603	TolB amino-terminal domain; Region: TolB_N; pfam04052
272568003604	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
272568003605	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
272568003606	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
272568003607	TolR protein; Region: tolR; TIGR02801
272568003608	TolQ protein; Region: tolQ; TIGR02796
272568003609	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
272568003610	active site
272568003611	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
272568003612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568003613	Walker A motif; other site
272568003614	ATP binding site [chemical binding]; other site
272568003615	Walker B motif; other site
272568003616	arginine finger; other site
272568003617	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
272568003618	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
272568003619	RuvA N terminal domain; Region: RuvA_N; pfam01330
272568003620	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
272568003621	active site
272568003622	putative DNA-binding cleft [nucleotide binding]; other site
272568003623	dimer interface [polypeptide binding]; other site
272568003624	hypothetical protein; Validated; Region: PRK00110
272568003625	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
272568003626	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
272568003627	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
272568003628	nucleotide binding region [chemical binding]; other site
272568003629	ATP-binding site [chemical binding]; other site
272568003630	SEC-C motif; Region: SEC-C; pfam02810
272568003631	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
272568003632	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
272568003633	heterotetramer interface [polypeptide binding]; other site
272568003634	active site pocket [active]
272568003635	cleavage site
272568003636	RDD family; Region: RDD; pfam06271
272568003637	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
272568003638	Mechanosensitive ion channel; Region: MS_channel; pfam00924
272568003639	Biofilm formation and stress response factor; Region: BsmA; pfam10014
272568003640	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
272568003641	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
272568003642	Permease; Region: Permease; pfam02405
272568003643	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
272568003644	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
272568003645	Walker A/P-loop; other site
272568003646	ATP binding site [chemical binding]; other site
272568003647	Q-loop/lid; other site
272568003648	ABC transporter signature motif; other site
272568003649	Walker B; other site
272568003650	D-loop; other site
272568003651	H-loop/switch region; other site
272568003652	mce related protein; Region: MCE; pfam02470
272568003653	Protein of unknown function (DUF330); Region: DUF330; pfam03886
272568003654	Purine nucleoside permease (NUP); Region: NUP; pfam06516
272568003655	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568003656	active site
272568003657	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
272568003658	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
272568003659	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
272568003660	homodimer interface [polypeptide binding]; other site
272568003661	substrate-cofactor binding pocket; other site
272568003662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568003663	catalytic residue [active]
272568003664	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
272568003665	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
272568003666	GTP cyclohydrolase I; Provisional; Region: PLN03044
272568003667	active site
272568003668	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
272568003669	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
272568003670	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
272568003671	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568003672	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
272568003673	dimerization interface [polypeptide binding]; other site
272568003674	peroxiredoxin; Region: AhpC; TIGR03137
272568003675	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
272568003676	dimer interface [polypeptide binding]; other site
272568003677	decamer (pentamer of dimers) interface [polypeptide binding]; other site
272568003678	catalytic triad [active]
272568003679	peroxidatic and resolving cysteines [active]
272568003680	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
272568003681	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
272568003682	catalytic residue [active]
272568003683	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
272568003684	catalytic residues [active]
272568003685	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568003686	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568003687	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
272568003688	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
272568003689	tetramer interface [polypeptide binding]; other site
272568003690	heme binding pocket [chemical binding]; other site
272568003691	NADPH binding site [chemical binding]; other site
272568003692	intracellular protease, PfpI family; Region: PfpI; TIGR01382
272568003693	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
272568003694	conserved cys residue [active]
272568003695	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
272568003696	MPT binding site; other site
272568003697	trimer interface [polypeptide binding]; other site
272568003698	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
272568003699	Uncharacterized conserved protein [Function unknown]; Region: COG4717
272568003700	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
272568003701	active site
272568003702	metal binding site [ion binding]; metal-binding site
272568003703	DNA binding site [nucleotide binding]
272568003704	Fusaric acid resistance protein family; Region: FUSC; pfam04632
272568003705	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
272568003706	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
272568003707	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568003708	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568003709	Phosphotransferase enzyme family; Region: APH; pfam01636
272568003710	Transposase; Region: HTH_Tnp_1; pfam01527
272568003711	putative transposase OrfB; Reviewed; Region: PHA02517
272568003712	HTH-like domain; Region: HTH_21; pfam13276
272568003713	Integrase core domain; Region: rve; pfam00665
272568003714	Integrase core domain; Region: rve_3; pfam13683
272568003715	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
272568003716	Winged helix-turn helix; Region: HTH_29; pfam13551
272568003717	Homeodomain-like domain; Region: HTH_32; pfam13565
272568003718	Winged helix-turn helix; Region: HTH_33; pfam13592
272568003719	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568003720	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
272568003721	DNA photolyase; Region: DNA_photolyase; pfam00875
272568003722	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
272568003723	DNA binding residues [nucleotide binding]
272568003724	chaperone protein DnaJ; Provisional; Region: PRK14299
272568003725	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
272568003726	HSP70 interaction site [polypeptide binding]; other site
272568003727	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
272568003728	substrate binding site [polypeptide binding]; other site
272568003729	dimer interface [polypeptide binding]; other site
272568003730	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
272568003731	Cysteine-rich domain; Region: CCG; pfam02754
272568003732	Cysteine-rich domain; Region: CCG; pfam02754
272568003733	FAD binding domain; Region: FAD_binding_4; pfam01565
272568003734	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
272568003735	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
272568003736	FAD binding domain; Region: FAD_binding_4; pfam01565
272568003737	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
272568003738	Cysteine-rich domain; Region: CCG; pfam02754
272568003739	Cysteine-rich domain; Region: CCG; pfam02754
272568003740	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
272568003741	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
272568003742	4Fe-4S binding domain; Region: Fer4; pfam00037
272568003743	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
272568003744	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
272568003745	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568003746	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568003747	active site
272568003748	catalytic tetrad [active]
272568003749	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
272568003750	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
272568003751	active site residue [active]
272568003752	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
272568003753	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
272568003754	dimer interface [polypeptide binding]; other site
272568003755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568003756	catalytic residue [active]
272568003757	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568003758	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568003759	putative substrate translocation pore; other site
272568003760	PRC-barrel domain; Region: PRC; pfam05239
272568003761	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568003762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568003763	active site
272568003764	phosphorylation site [posttranslational modification]
272568003765	intermolecular recognition site; other site
272568003766	dimerization interface [polypeptide binding]; other site
272568003767	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568003768	DNA binding site [nucleotide binding]
272568003769	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
272568003770	dimerization interface [polypeptide binding]; other site
272568003771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568003772	ATP binding site [chemical binding]; other site
272568003773	Mg2+ binding site [ion binding]; other site
272568003774	G-X-G motif; other site
272568003775	Predicted membrane protein [Function unknown]; Region: COG1238
272568003776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568003777	NAD(P) binding site [chemical binding]; other site
272568003778	active site
272568003779	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
272568003780	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
272568003781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568003782	TPR motif; other site
272568003783	binding surface
272568003784	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
272568003785	Fe-S cluster binding site [ion binding]; other site
272568003786	active site
272568003787	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
272568003788	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568003789	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568003790	catalytic residue [active]
272568003791	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
272568003792	Domain of unknown function DUF21; Region: DUF21; pfam01595
272568003793	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
272568003794	Transporter associated domain; Region: CorC_HlyC; smart01091
272568003795	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
272568003796	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568003797	FeS/SAM binding site; other site
272568003798	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
272568003799	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
272568003800	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
272568003801	TPP-binding site; other site
272568003802	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
272568003803	PYR/PP interface [polypeptide binding]; other site
272568003804	dimer interface [polypeptide binding]; other site
272568003805	TPP binding site [chemical binding]; other site
272568003806	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
272568003807	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
272568003808	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
272568003809	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
272568003810	ligand binding site; other site
272568003811	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
272568003812	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
272568003813	B12 binding site [chemical binding]; other site
272568003814	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568003815	FeS/SAM binding site; other site
272568003816	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
272568003817	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
272568003818	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
272568003819	catalytic residues [active]
272568003820	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
272568003821	Family description; Region: UvrD_C_2; pfam13538
272568003822	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
272568003823	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
272568003824	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
272568003825	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
272568003826	Substrate binding site; other site
272568003827	metal-binding site
272568003828	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
272568003829	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
272568003830	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568003831	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
272568003832	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
272568003833	active site
272568003834	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
272568003835	dimer interface [polypeptide binding]; other site
272568003836	substrate binding site [chemical binding]; other site
272568003837	catalytic residues [active]
272568003838	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
272568003839	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568003840	hydroxyglutarate oxidase; Provisional; Region: PRK11728
272568003841	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
272568003842	Nitrogen regulatory protein P-II; Region: P-II; smart00938
272568003843	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
272568003844	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
272568003845	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
272568003846	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
272568003847	G1 box; other site
272568003848	putative GEF interaction site [polypeptide binding]; other site
272568003849	GTP/Mg2+ binding site [chemical binding]; other site
272568003850	Switch I region; other site
272568003851	G2 box; other site
272568003852	G3 box; other site
272568003853	Switch II region; other site
272568003854	G4 box; other site
272568003855	G5 box; other site
272568003856	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
272568003857	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
272568003858	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
272568003859	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
272568003860	substrate binding site [chemical binding]; other site
272568003861	ATP binding site [chemical binding]; other site
272568003862	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
272568003863	GcrA cell cycle regulator; Region: GcrA; cl11564
272568003864	GcrA cell cycle regulator; Region: GcrA; cl11564
272568003865	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
272568003866	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
272568003867	catalytic site [active]
272568003868	putative active site [active]
272568003869	putative substrate binding site [chemical binding]; other site
272568003870	HRDC domain; Region: HRDC; pfam00570
272568003871	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
272568003872	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
272568003873	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
272568003874	gamma subunit interface [polypeptide binding]; other site
272568003875	epsilon subunit interface [polypeptide binding]; other site
272568003876	LBP interface [polypeptide binding]; other site
272568003877	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
272568003878	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
272568003879	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
272568003880	alpha subunit interaction interface [polypeptide binding]; other site
272568003881	Walker A motif; other site
272568003882	ATP binding site [chemical binding]; other site
272568003883	Walker B motif; other site
272568003884	inhibitor binding site; inhibition site
272568003885	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
272568003886	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
272568003887	core domain interface [polypeptide binding]; other site
272568003888	delta subunit interface [polypeptide binding]; other site
272568003889	epsilon subunit interface [polypeptide binding]; other site
272568003890	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
272568003891	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
272568003892	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
272568003893	beta subunit interaction interface [polypeptide binding]; other site
272568003894	Walker A motif; other site
272568003895	ATP binding site [chemical binding]; other site
272568003896	Walker B motif; other site
272568003897	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
272568003898	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
272568003899	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
272568003900	Transcriptional regulators [Transcription]; Region: PurR; COG1609
272568003901	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
272568003902	DNA binding site [nucleotide binding]
272568003903	domain linker motif; other site
272568003904	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
272568003905	putative dimerization interface [polypeptide binding]; other site
272568003906	putative ligand binding site [chemical binding]; other site
272568003907	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
272568003908	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
272568003909	NADP binding site [chemical binding]; other site
272568003910	homodimer interface [polypeptide binding]; other site
272568003911	active site
272568003912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568003913	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
272568003914	putative substrate translocation pore; other site
272568003915	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
272568003916	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
272568003917	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
272568003918	putative homodimer interface [polypeptide binding]; other site
272568003919	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
272568003920	heterodimer interface [polypeptide binding]; other site
272568003921	homodimer interface [polypeptide binding]; other site
272568003922	Protein of unknown function (DUF330); Region: DUF330; pfam03886
272568003923	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
272568003924	mce related protein; Region: MCE; pfam02470
272568003925	mce related protein; Region: MCE; pfam02470
272568003926	mce related protein; Region: MCE; pfam02470
272568003927	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
272568003928	Paraquat-inducible protein A; Region: PqiA; pfam04403
272568003929	Paraquat-inducible protein A; Region: PqiA; pfam04403
272568003930	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568003931	putative substrate translocation pore; other site
272568003932	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
272568003933	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
272568003934	trimer interface [polypeptide binding]; other site
272568003935	putative metal binding site [ion binding]; other site
272568003936	Transcriptional regulators [Transcription]; Region: GntR; COG1802
272568003937	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568003938	DNA-binding site [nucleotide binding]; DNA binding site
272568003939	FCD domain; Region: FCD; pfam07729
272568003940	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568003941	D-galactonate transporter; Region: 2A0114; TIGR00893
272568003942	putative substrate translocation pore; other site
272568003943	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
272568003944	CoA-transferase family III; Region: CoA_transf_3; pfam02515
272568003945	enoyl-CoA hydratase; Provisional; Region: PRK06144
272568003946	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
272568003947	substrate binding site [chemical binding]; other site
272568003948	oxyanion hole (OAH) forming residues; other site
272568003949	trimer interface [polypeptide binding]; other site
272568003950	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
272568003951	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
272568003952	active site
272568003953	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
272568003954	generic binding surface II; other site
272568003955	generic binding surface I; other site
272568003956	DNA Polymerase Y-family; Region: PolY_like; cd03468
272568003957	active site
272568003958	DNA binding site [nucleotide binding]
272568003959	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
272568003960	Uncharacterized conserved protein [Function unknown]; Region: COG4544
272568003961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568003962	NAD(P) binding site [chemical binding]; other site
272568003963	active site
272568003964	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
272568003965	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
272568003966	dimerization interface [polypeptide binding]; other site
272568003967	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568003968	dimer interface [polypeptide binding]; other site
272568003969	phosphorylation site [posttranslational modification]
272568003970	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568003971	ATP binding site [chemical binding]; other site
272568003972	Mg2+ binding site [ion binding]; other site
272568003973	G-X-G motif; other site
272568003974	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568003975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568003976	active site
272568003977	phosphorylation site [posttranslational modification]
272568003978	intermolecular recognition site; other site
272568003979	dimerization interface [polypeptide binding]; other site
272568003980	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568003981	DNA binding site [nucleotide binding]
272568003982	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568003983	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
272568003984	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
272568003985	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
272568003986	putative active site [active]
272568003987	putative metal binding site [ion binding]; other site
272568003988	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
272568003989	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568003990	N-terminal plug; other site
272568003991	ligand-binding site [chemical binding]; other site
272568003992	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
272568003993	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
272568003994	intersubunit interface [polypeptide binding]; other site
272568003995	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
272568003996	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
272568003997	putative PBP binding regions; other site
272568003998	ABC-ATPase subunit  interface; other site
272568003999	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
272568004000	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
272568004001	Walker A/P-loop; other site
272568004002	ATP binding site [chemical binding]; other site
272568004003	Q-loop/lid; other site
272568004004	ABC transporter signature motif; other site
272568004005	Walker B; other site
272568004006	D-loop; other site
272568004007	H-loop/switch region; other site
272568004008	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
272568004009	catalytic core [active]
272568004010	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
272568004011	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
272568004012	PhnA protein; Region: PhnA; pfam03831
272568004013	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160
272568004014	active site
272568004015	Predicted membrane protein [Function unknown]; Region: COG2855
272568004016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568004017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568004018	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
272568004019	putative dimerization interface [polypeptide binding]; other site
272568004020	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
272568004021	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568004022	active site
272568004023	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568004024	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
272568004025	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
272568004026	FMN binding site [chemical binding]; other site
272568004027	dimer interface [polypeptide binding]; other site
272568004028	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
272568004029	manganese transport protein MntH; Reviewed; Region: PRK00701
272568004030	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
272568004031	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
272568004032	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
272568004033	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
272568004034	Fe2+ transport protein; Region: Iron_transport; cl01377
272568004035	Iron permease FTR1 family; Region: FTR1; cl00475
272568004036	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
272568004037	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
272568004038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568004039	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
272568004040	putative substrate translocation pore; other site
272568004041	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
272568004042	DNA-binding interface [nucleotide binding]; DNA binding site
272568004043	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
272568004044	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
272568004045	NAD(P) binding site [chemical binding]; other site
272568004046	catalytic residues [active]
272568004047	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568004048	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
272568004049	Coenzyme A binding pocket [chemical binding]; other site
272568004050	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
272568004051	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
272568004052	arogenate dehydrogenase; Region: PLN02256
272568004053	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
272568004054	dimerization interface [polypeptide binding]; other site
272568004055	metal binding site [ion binding]; metal-binding site
272568004056	potassium uptake protein; Region: kup; TIGR00794
272568004057	K+ potassium transporter; Region: K_trans; pfam02705
272568004058	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
272568004059	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568004060	Predicted permeases [General function prediction only]; Region: COG0795
272568004061	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
272568004062	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
272568004063	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
272568004064	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
272568004065	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
272568004066	active site
272568004067	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
272568004068	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
272568004069	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
272568004070	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
272568004071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568004072	putative substrate translocation pore; other site
272568004073	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
272568004074	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
272568004075	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
272568004076	CsbD-like; Region: CsbD; pfam05532
272568004077	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
272568004078	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568004079	putative DNA binding site [nucleotide binding]; other site
272568004080	putative Zn2+ binding site [ion binding]; other site
272568004081	AsnC family; Region: AsnC_trans_reg; pfam01037
272568004082	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568004083	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568004084	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568004085	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
272568004086	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568004087	putative Zn2+ binding site [ion binding]; other site
272568004088	putative DNA binding site [nucleotide binding]; other site
272568004089	dimerization interface [polypeptide binding]; other site
272568004090	AsnC family; Region: AsnC_trans_reg; pfam01037
272568004091	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
272568004092	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568004093	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568004094	catalytic residue [active]
272568004095	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
272568004096	ThiC-associated domain; Region: ThiC-associated; pfam13667
272568004097	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
272568004098	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
272568004099	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
272568004100	active site
272568004101	catalytic residue [active]
272568004102	dimer interface [polypeptide binding]; other site
272568004103	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
272568004104	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
272568004105	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
272568004106	active site
272568004107	substrate-binding site [chemical binding]; other site
272568004108	metal-binding site [ion binding]
272568004109	ATP binding site [chemical binding]; other site
272568004110	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
272568004111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568004112	putative substrate translocation pore; other site
272568004113	aspartate aminotransferase; Provisional; Region: PRK05764
272568004114	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568004115	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568004116	homodimer interface [polypeptide binding]; other site
272568004117	catalytic residue [active]
272568004118	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
272568004119	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568004120	putative substrate translocation pore; other site
272568004121	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
272568004122	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
272568004123	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
272568004124	active site
272568004125	Lysine efflux permease [General function prediction only]; Region: COG1279
272568004126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568004127	binding surface
272568004128	TPR motif; other site
272568004129	TPR repeat; Region: TPR_11; pfam13414
272568004130	TPR repeat; Region: TPR_11; pfam13414
272568004131	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568004132	binding surface
272568004133	TPR motif; other site
272568004134	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
272568004135	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
272568004136	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568004137	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
272568004138	dimerization interface [polypeptide binding]; other site
272568004139	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568004140	DNA-binding site [nucleotide binding]; DNA binding site
272568004141	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
272568004142	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568004143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568004144	homodimer interface [polypeptide binding]; other site
272568004145	catalytic residue [active]
272568004146	Uncharacterized conserved protein [Function unknown]; Region: COG1359
272568004147	hypothetical protein; Provisional; Region: PRK02399
272568004148	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
272568004149	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
272568004150	Major royal jelly protein; Region: MRJP; pfam03022
272568004151	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
272568004152	dimer interface [polypeptide binding]; other site
272568004153	FMN binding site [chemical binding]; other site
272568004154	Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690
272568004155	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
272568004156	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
272568004157	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
272568004158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568004159	ATP binding site [chemical binding]; other site
272568004160	Mg2+ binding site [ion binding]; other site
272568004161	G-X-G motif; other site
272568004162	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
272568004163	ATP binding site [chemical binding]; other site
272568004164	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
272568004165	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
272568004166	lipoprotein signal peptidase; Provisional; Region: PRK14770
272568004167	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
272568004168	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
272568004169	active site
272568004170	HIGH motif; other site
272568004171	nucleotide binding site [chemical binding]; other site
272568004172	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
272568004173	active site
272568004174	KMSKS motif; other site
272568004175	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
272568004176	tRNA binding surface [nucleotide binding]; other site
272568004177	anticodon binding site; other site
272568004178	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
272568004179	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
272568004180	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
272568004181	active site
272568004182	Riboflavin kinase; Region: Flavokinase; smart00904
272568004183	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
272568004184	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
272568004185	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
272568004186	Cupin domain; Region: Cupin_2; pfam07883
272568004187	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
272568004188	intersubunit interface [polypeptide binding]; other site
272568004189	active site
272568004190	Zn2+ binding site [ion binding]; other site
272568004191	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
272568004192	CHAP domain; Region: CHAP; cl17642
272568004193	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
272568004194	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568004195	S-adenosylmethionine binding site [chemical binding]; other site
272568004196	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
272568004197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568004198	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
272568004199	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
272568004200	dimerization interface [polypeptide binding]; other site
272568004201	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
272568004202	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
272568004203	dimer interface [polypeptide binding]; other site
272568004204	decamer (pentamer of dimers) interface [polypeptide binding]; other site
272568004205	catalytic triad [active]
272568004206	peroxidatic and resolving cysteines [active]
272568004207	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
272568004208	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
272568004209	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
272568004210	Low molecular weight phosphatase family; Region: LMWPc; cd00115
272568004211	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
272568004212	active site
272568004213	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
272568004214	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
272568004215	dimerization interface [polypeptide binding]; other site
272568004216	active site
272568004217	L-aspartate oxidase; Provisional; Region: PRK07512
272568004218	L-aspartate oxidase; Provisional; Region: PRK06175
272568004219	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
272568004220	quinolinate synthetase; Provisional; Region: PRK09375
272568004221	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
272568004222	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
272568004223	NnrU protein; Region: NnrU; pfam07298
272568004224	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568004225	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
272568004226	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
272568004227	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568004228	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568004229	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568004230	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
272568004231	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568004232	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
272568004233	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568004234	Sel1-like repeats; Region: SEL1; smart00671
272568004235	Sel1-like repeats; Region: SEL1; smart00671
272568004236	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568004237	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
272568004238	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568004239	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568004240	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
272568004241	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
272568004242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568004243	Walker A/P-loop; other site
272568004244	ATP binding site [chemical binding]; other site
272568004245	Q-loop/lid; other site
272568004246	ABC transporter signature motif; other site
272568004247	Walker B; other site
272568004248	D-loop; other site
272568004249	H-loop/switch region; other site
272568004250	Winged helix-turn helix; Region: HTH_29; pfam13551
272568004251	Homeodomain-like domain; Region: HTH_32; pfam13565
272568004252	Winged helix-turn helix; Region: HTH_33; pfam13592
272568004253	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568004254	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
272568004255	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
272568004256	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
272568004257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568004258	Walker A/P-loop; other site
272568004259	ATP binding site [chemical binding]; other site
272568004260	Q-loop/lid; other site
272568004261	ABC transporter signature motif; other site
272568004262	Walker B; other site
272568004263	D-loop; other site
272568004264	H-loop/switch region; other site
272568004265	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
272568004266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568004267	dimer interface [polypeptide binding]; other site
272568004268	conserved gate region; other site
272568004269	putative PBP binding loops; other site
272568004270	ABC-ATPase subunit interface; other site
272568004271	sulfate transport protein; Provisional; Region: cysT; CHL00187
272568004272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568004273	dimer interface [polypeptide binding]; other site
272568004274	conserved gate region; other site
272568004275	putative PBP binding loops; other site
272568004276	ABC-ATPase subunit interface; other site
272568004277	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
272568004278	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
272568004279	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
272568004280	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
272568004281	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
272568004282	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568004283	oxidoreductase; Provisional; Region: PRK06196
272568004284	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568004285	NAD(P) binding site [chemical binding]; other site
272568004286	active site
272568004287	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568004288	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568004289	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568004290	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568004291	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568004292	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
272568004293	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
272568004294	active sites [active]
272568004295	tetramer interface [polypeptide binding]; other site
272568004296	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
272568004297	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
272568004298	[2Fe-2S] cluster binding site [ion binding]; other site
272568004299	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
272568004300	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
272568004301	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
272568004302	active site
272568004303	catalytic site [active]
272568004304	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
272568004305	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
272568004306	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
272568004307	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
272568004308	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
272568004309	catalytic site [active]
272568004310	active site
272568004311	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
272568004312	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
272568004313	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
272568004314	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
272568004315	active site
272568004316	catalytic site [active]
272568004317	glycogen branching enzyme; Provisional; Region: PRK05402
272568004318	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
272568004319	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
272568004320	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
272568004321	active site
272568004322	catalytic site [active]
272568004323	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
272568004324	glycogen synthase; Provisional; Region: PRK14099
272568004325	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
272568004326	ADP-binding pocket [chemical binding]; other site
272568004327	homodimer interface [polypeptide binding]; other site
272568004328	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
272568004329	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
272568004330	Bacterial transcriptional regulator; Region: IclR; pfam01614
272568004331	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
272568004332	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
272568004333	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
272568004334	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
272568004335	Trp docking motif [polypeptide binding]; other site
272568004336	putative active site [active]
272568004337	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568004338	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568004339	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
272568004340	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
272568004341	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
272568004342	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
272568004343	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
272568004344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568004345	putative substrate translocation pore; other site
272568004346	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
272568004347	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
272568004348	23S rRNA interface [nucleotide binding]; other site
272568004349	L3 interface [polypeptide binding]; other site
272568004350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568004351	NADH(P)-binding; Region: NAD_binding_10; pfam13460
272568004352	NAD(P) binding site [chemical binding]; other site
272568004353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568004354	hypothetical protein; Provisional; Region: PRK08912
272568004355	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568004356	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568004357	homodimer interface [polypeptide binding]; other site
272568004358	catalytic residue [active]
272568004359	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
272568004360	Nitrogen regulatory protein P-II; Region: P-II; smart00938
272568004361	glutamine synthetase; Provisional; Region: glnA; PRK09469
272568004362	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
272568004363	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
272568004364	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
272568004365	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
272568004366	Cl- selectivity filter; other site
272568004367	Cl- binding residues [ion binding]; other site
272568004368	pore gating glutamate residue; other site
272568004369	dimer interface [polypeptide binding]; other site
272568004370	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
272568004371	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
272568004372	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
272568004373	NAD(P) binding site [chemical binding]; other site
272568004374	acyl-CoA esterase; Provisional; Region: PRK10673
272568004375	PGAP1-like protein; Region: PGAP1; pfam07819
272568004376	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
272568004377	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
272568004378	minor groove reading motif; other site
272568004379	helix-hairpin-helix signature motif; other site
272568004380	active site
272568004381	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
272568004382	AMP nucleosidase; Provisional; Region: PRK08292
272568004383	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
272568004384	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
272568004385	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
272568004386	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
272568004387	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
272568004388	putative active site [active]
272568004389	metal binding site [ion binding]; metal-binding site
272568004390	homodimer binding site [polypeptide binding]; other site
272568004391	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
272568004392	Cell division protein ZapA; Region: ZapA; pfam05164
272568004393	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
272568004394	active site
272568004395	thiamine phosphate binding site [chemical binding]; other site
272568004396	pyrophosphate binding site [ion binding]; other site
272568004397	Fasciclin domain; Region: Fasciclin; cl02663
272568004398	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
272568004399	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
272568004400	motif 1; other site
272568004401	dimer interface [polypeptide binding]; other site
272568004402	active site
272568004403	motif 2; other site
272568004404	motif 3; other site
272568004405	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
272568004406	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568004407	FeS/SAM binding site; other site
272568004408	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
272568004409	elongation factor P; Validated; Region: PRK00529
272568004410	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
272568004411	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
272568004412	RNA binding site [nucleotide binding]; other site
272568004413	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
272568004414	RNA binding site [nucleotide binding]; other site
272568004415	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
272568004416	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
272568004417	active site
272568004418	dimerization interface [polypeptide binding]; other site
272568004419	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
272568004420	ligand binding site [chemical binding]; other site
272568004421	hypothetical protein; Validated; Region: PRK09039
272568004422	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
272568004423	ligand binding site [chemical binding]; other site
272568004424	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
272568004425	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
272568004426	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568004427	Radical SAM superfamily; Region: Radical_SAM; pfam04055
272568004428	FeS/SAM binding site; other site
272568004429	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
272568004430	putative ADP-binding pocket [chemical binding]; other site
272568004431	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568004432	Predicted integral membrane protein [Function unknown]; Region: COG5617
272568004433	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
272568004434	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568004435	sequence-specific DNA binding site [nucleotide binding]; other site
272568004436	salt bridge; other site
272568004437	Predicted transcriptional regulator [Transcription]; Region: COG2932
272568004438	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
272568004439	Catalytic site [active]
272568004440	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
272568004441	putative ADP-binding pocket [chemical binding]; other site
272568004442	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568004443	Transcriptional regulator; Region: Rrf2; cl17282
272568004444	Rrf2 family protein; Region: rrf2_super; TIGR00738
272568004445	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
272568004446	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
272568004447	heme-binding site [chemical binding]; other site
272568004448	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
272568004449	FAD binding pocket [chemical binding]; other site
272568004450	FAD binding motif [chemical binding]; other site
272568004451	phosphate binding motif [ion binding]; other site
272568004452	beta-alpha-beta structure motif; other site
272568004453	NAD binding pocket [chemical binding]; other site
272568004454	Heme binding  pocket [chemical binding]; other site
272568004455	Uncharacterized conserved protein [Function unknown]; Region: COG3189
272568004456	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
272568004457	catalytic residue [active]
272568004458	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
272568004459	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
272568004460	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
272568004461	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
272568004462	Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741
272568004463	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
272568004464	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
272568004465	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
272568004466	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
272568004467	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
272568004468	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
272568004469	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
272568004470	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
272568004471	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
272568004472	Walker A motif; other site
272568004473	ATP binding site [chemical binding]; other site
272568004474	Walker B motif; other site
272568004475	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
272568004476	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
272568004477	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
272568004478	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568004479	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568004480	catalytic residue [active]
272568004481	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
272568004482	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
272568004483	substrate binding [chemical binding]; other site
272568004484	active site
272568004485	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
272568004486	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
272568004487	active site
272568004488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
272568004489	CAAX protease self-immunity; Region: Abi; pfam02517
272568004490	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
272568004491	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
272568004492	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
272568004493	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568004494	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
272568004495	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
272568004496	DNA binding site [nucleotide binding]
272568004497	active site
272568004498	Pirin-related protein [General function prediction only]; Region: COG1741
272568004499	Pirin; Region: Pirin; pfam02678
272568004500	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
272568004501	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
272568004502	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
272568004503	putative heme binding pocket [chemical binding]; other site
272568004504	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
272568004505	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
272568004506	Walker A/P-loop; other site
272568004507	ATP binding site [chemical binding]; other site
272568004508	Q-loop/lid; other site
272568004509	ABC transporter signature motif; other site
272568004510	Walker B; other site
272568004511	D-loop; other site
272568004512	H-loop/switch region; other site
272568004513	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
272568004514	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
272568004515	Walker A/P-loop; other site
272568004516	ATP binding site [chemical binding]; other site
272568004517	Q-loop/lid; other site
272568004518	ABC transporter signature motif; other site
272568004519	Walker B; other site
272568004520	D-loop; other site
272568004521	H-loop/switch region; other site
272568004522	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
272568004523	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
272568004524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568004525	dimer interface [polypeptide binding]; other site
272568004526	conserved gate region; other site
272568004527	ABC-ATPase subunit interface; other site
272568004528	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
272568004529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568004530	ABC-ATPase subunit interface; other site
272568004531	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
272568004532	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
272568004533	acetylornithine deacetylase; Provisional; Region: PRK07522
272568004534	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
272568004535	metal binding site [ion binding]; metal-binding site
272568004536	putative dimer interface [polypeptide binding]; other site
272568004537	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
272568004538	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
272568004539	NAD(P) binding site [chemical binding]; other site
272568004540	catalytic residues [active]
272568004541	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
272568004542	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
272568004543	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
272568004544	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
272568004545	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
272568004546	hydroxyglutarate oxidase; Provisional; Region: PRK11728
272568004547	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568004548	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568004549	active site
272568004550	catalytic tetrad [active]
272568004551	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
272568004552	heme-binding site [chemical binding]; other site
272568004553	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
272568004554	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
272568004555	dimer interface [polypeptide binding]; other site
272568004556	putative CheW interface [polypeptide binding]; other site
272568004557	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
272568004558	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
272568004559	dimerization interface [polypeptide binding]; other site
272568004560	active site
272568004561	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
272568004562	oxidoreductase; Provisional; Region: PRK10015
272568004563	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
272568004564	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
272568004565	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
272568004566	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
272568004567	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
272568004568	Ligand binding site [chemical binding]; other site
272568004569	Electron transfer flavoprotein domain; Region: ETF; pfam01012
272568004570	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810
272568004571	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
272568004572	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
272568004573	active site
272568004574	catalytic residues [active]
272568004575	metal binding site [ion binding]; metal-binding site
272568004576	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
272568004577	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
272568004578	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568004579	catalytic residue [active]
272568004580	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
272568004581	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
272568004582	trimerization site [polypeptide binding]; other site
272568004583	active site
272568004584	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
272568004585	NifU-like domain; Region: NifU; pfam01106
272568004586	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
272568004587	NifQ; Region: NifQ; pfam04891
272568004588	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
272568004589	Rop-like; Region: Rop-like; pfam05082
272568004590	probable nitrogen fixation protein; Region: TIGR02935
272568004591	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
272568004592	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
272568004593	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
272568004594	nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478
272568004595	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
272568004596	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
272568004597	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
272568004598	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
272568004599	MoFe protein beta/alpha subunit interactions; other site
272568004600	Beta subunit P cluster binding residues; other site
272568004601	MoFe protein beta subunit/Fe protein contacts; other site
272568004602	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
272568004603	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
272568004604	MoFe protein alpha/beta subunit interactions; other site
272568004605	Alpha subunit P cluster binding residues; other site
272568004606	FeMoco binding residues [chemical binding]; other site
272568004607	MoFe protein alpha subunit/Fe protein contacts; other site
272568004608	MoFe protein dimer/ dimer interactions; other site
272568004609	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
272568004610	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
272568004611	Nucleotide-binding sites [chemical binding]; other site
272568004612	Walker A motif; other site
272568004613	Switch I region of nucleotide binding site; other site
272568004614	Fe4S4 binding sites [ion binding]; other site
272568004615	Switch II region of nucleotide binding site; other site
272568004616	SIR2-like domain; Region: SIR2_2; pfam13289
272568004617	NifT/FixU protein; Region: NifT; pfam06988
272568004618	NifZ domain; Region: NifZ; pfam04319
272568004619	LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484
272568004620	hypothetical protein; Provisional; Region: PRK13795
272568004621	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
272568004622	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568004623	FeS/SAM binding site; other site
272568004624	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
272568004625	Nif-specific regulatory protein; Region: nifA; TIGR01817
272568004626	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
272568004627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568004628	Walker A motif; other site
272568004629	ATP binding site [chemical binding]; other site
272568004630	Walker B motif; other site
272568004631	arginine finger; other site
272568004632	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
272568004633	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
272568004634	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
272568004635	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
272568004636	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
272568004637	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568004638	dimer interface [polypeptide binding]; other site
272568004639	conserved gate region; other site
272568004640	putative PBP binding loops; other site
272568004641	ABC-ATPase subunit interface; other site
272568004642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568004643	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
272568004644	Walker A/P-loop; other site
272568004645	ATP binding site [chemical binding]; other site
272568004646	Q-loop/lid; other site
272568004647	ABC transporter signature motif; other site
272568004648	Walker B; other site
272568004649	D-loop; other site
272568004650	H-loop/switch region; other site
272568004651	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
272568004652	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
272568004653	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
272568004654	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
272568004655	hypothetical protein; Provisional; Region: PRK05965
272568004656	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
272568004657	inhibitor-cofactor binding pocket; inhibition site
272568004658	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568004659	catalytic residue [active]
272568004660	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
272568004661	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568004662	putative DNA binding site [nucleotide binding]; other site
272568004663	putative Zn2+ binding site [ion binding]; other site
272568004664	AsnC family; Region: AsnC_trans_reg; pfam01037
272568004665	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
272568004666	tartrate dehydrogenase; Region: TTC; TIGR02089
272568004667	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568004668	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568004669	N-terminal plug; other site
272568004670	ligand-binding site [chemical binding]; other site
272568004671	succinic semialdehyde dehydrogenase; Region: PLN02278
272568004672	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
272568004673	tetramerization interface [polypeptide binding]; other site
272568004674	NAD(P) binding site [chemical binding]; other site
272568004675	catalytic residues [active]
272568004676	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
272568004677	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
272568004678	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
272568004679	Coenzyme A binding pocket [chemical binding]; other site
272568004680	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
272568004681	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
272568004682	putative ligand binding site [chemical binding]; other site
272568004683	NAD binding site [chemical binding]; other site
272568004684	dimerization interface [polypeptide binding]; other site
272568004685	catalytic site [active]
272568004686	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
272568004687	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
272568004688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568004689	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568004690	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568004691	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568004692	transposase/IS protein; Provisional; Region: PRK09183
272568004693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568004694	Walker A motif; other site
272568004695	ATP binding site [chemical binding]; other site
272568004696	putative transposase OrfB; Reviewed; Region: PHA02517
272568004697	HTH-like domain; Region: HTH_21; pfam13276
272568004698	Integrase core domain; Region: rve; pfam00665
272568004699	Integrase core domain; Region: rve_3; cl15866
272568004700	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
272568004701	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
272568004702	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
272568004703	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
272568004704	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568004705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568004706	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568004707	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
272568004708	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568004709	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568004710	catalytic residue [active]
272568004711	Protein of unknown function (DUF736); Region: DUF736; pfam05284
272568004712	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
272568004713	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
272568004714	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
272568004715	Replication initiator protein A; Region: RPA; pfam10134
272568004716	Helix-turn-helix domain; Region: HTH_17; pfam12728
272568004717	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
272568004718	DNA methylase; Region: N6_N4_Mtase; cl17433
272568004719	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
272568004720	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
272568004721	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568004722	non-specific DNA binding site [nucleotide binding]; other site
272568004723	salt bridge; other site
272568004724	sequence-specific DNA binding site [nucleotide binding]; other site
272568004725	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
272568004726	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
272568004727	catalytic residues [active]
272568004728	catalytic nucleophile [active]
272568004729	Recombinase; Region: Recombinase; pfam07508
272568004730	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
272568004731	hypothetical protein; Provisional; Region: PRK09126
272568004732	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
272568004733	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
272568004734	putative FMN binding site [chemical binding]; other site
272568004735	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
272568004736	putative active site pocket [active]
272568004737	4-fold oligomerization interface [polypeptide binding]; other site
272568004738	metal binding residues [ion binding]; metal-binding site
272568004739	3-fold/trimer interface [polypeptide binding]; other site
272568004740	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
272568004741	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
272568004742	putative active site [active]
272568004743	oxyanion strand; other site
272568004744	catalytic triad [active]
272568004745	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
272568004746	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
272568004747	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
272568004748	catalytic residues [active]
272568004749	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
272568004750	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
272568004751	substrate binding site [chemical binding]; other site
272568004752	glutamase interaction surface [polypeptide binding]; other site
272568004753	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
272568004754	metal binding site [ion binding]; metal-binding site
272568004755	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
272568004756	nucleotide binding site/active site [active]
272568004757	HIT family signature motif; other site
272568004758	catalytic residue [active]
272568004759	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
272568004760	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
272568004761	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
272568004762	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
272568004763	oligomeric interface; other site
272568004764	putative active site [active]
272568004765	homodimer interface [polypeptide binding]; other site
272568004766	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
272568004767	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
272568004768	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
272568004769	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
272568004770	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
272568004771	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
272568004772	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
272568004773	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
272568004774	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
272568004775	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
272568004776	Walker A/P-loop; other site
272568004777	ATP binding site [chemical binding]; other site
272568004778	Q-loop/lid; other site
272568004779	ABC transporter signature motif; other site
272568004780	Walker B; other site
272568004781	D-loop; other site
272568004782	H-loop/switch region; other site
272568004783	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
272568004784	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
272568004785	minor groove reading motif; other site
272568004786	helix-hairpin-helix signature motif; other site
272568004787	substrate binding pocket [chemical binding]; other site
272568004788	active site
272568004789	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
272568004790	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
272568004791	Competence protein; Region: Competence; pfam03772
272568004792	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
272568004793	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
272568004794	HIGH motif; other site
272568004795	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
272568004796	active site
272568004797	KMSKS motif; other site
272568004798	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
272568004799	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
272568004800	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
272568004801	dihydroorotase; Validated; Region: pyrC; PRK09357
272568004802	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568004803	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
272568004804	active site
272568004805	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
272568004806	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
272568004807	DNA protecting protein DprA; Region: dprA; TIGR00732
272568004808	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
272568004809	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
272568004810	active site
272568004811	interdomain interaction site; other site
272568004812	putative metal-binding site [ion binding]; other site
272568004813	nucleotide binding site [chemical binding]; other site
272568004814	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
272568004815	domain I; other site
272568004816	DNA binding groove [nucleotide binding]
272568004817	phosphate binding site [ion binding]; other site
272568004818	domain II; other site
272568004819	domain III; other site
272568004820	nucleotide binding site [chemical binding]; other site
272568004821	catalytic site [active]
272568004822	domain IV; other site
272568004823	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
272568004824	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
272568004825	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
272568004826	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
272568004827	ribonuclease R; Region: RNase_R; TIGR02063
272568004828	RNB domain; Region: RNB; pfam00773
272568004829	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
272568004830	RNA binding site [nucleotide binding]; other site
272568004831	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
272568004832	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
272568004833	Catalytic dyad [active]
272568004834	Kinase-interacting domains of the HopAB family of Type III Effector proteins; Region: HopAB_KID; cl17109
272568004835	kinase binding site [polypeptide binding]; other site
272568004836	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
272568004837	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
272568004838	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
272568004839	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
272568004840	ligand binding site [chemical binding]; other site
272568004841	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568004842	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568004843	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
272568004844	dimerization interface [polypeptide binding]; other site
272568004845	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
272568004846	Fusaric acid resistance protein family; Region: FUSC; pfam04632
272568004847	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
272568004848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568004849	putative sialic acid transporter; Region: 2A0112; TIGR00891
272568004850	putative substrate translocation pore; other site
272568004851	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
272568004852	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568004853	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
272568004854	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568004855	catalytic residue [active]
272568004856	cobyric acid synthase; Provisional; Region: PRK00784
272568004857	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
272568004858	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
272568004859	catalytic triad [active]
272568004860	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
272568004861	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
272568004862	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
272568004863	homodimer interface [polypeptide binding]; other site
272568004864	Walker A motif; other site
272568004865	ATP binding site [chemical binding]; other site
272568004866	hydroxycobalamin binding site [chemical binding]; other site
272568004867	Walker B motif; other site
272568004868	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
272568004869	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568004870	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568004871	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568004872	putative transposase OrfB; Reviewed; Region: PHA02517
272568004873	HTH-like domain; Region: HTH_21; pfam13276
272568004874	Integrase core domain; Region: rve; pfam00665
272568004875	Integrase core domain; Region: rve_3; cl15866
272568004876	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568004877	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568004878	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568004879	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568004880	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568004881	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568004882	Winged helix-turn helix; Region: HTH_29; pfam13551
272568004883	Integrase core domain; Region: rve; pfam00665
272568004884	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
272568004885	Integrase core domain; Region: rve_3; pfam13683
272568004886	Transcriptional regulators [Transcription]; Region: MarR; COG1846
272568004887	MarR family; Region: MarR; pfam01047
272568004888	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
272568004889	MAPEG family; Region: MAPEG; cl09190
272568004890	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568004891	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568004892	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
272568004893	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
272568004894	NADP binding site [chemical binding]; other site
272568004895	dimer interface [polypeptide binding]; other site
272568004896	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
272568004897	transposase/IS protein; Provisional; Region: PRK09183
272568004898	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568004899	Walker A motif; other site
272568004900	ATP binding site [chemical binding]; other site
272568004901	Winged helix-turn helix; Region: HTH_29; pfam13551
272568004902	Helix-turn-helix domain; Region: HTH_28; pfam13518
272568004903	Integrase core domain; Region: rve; pfam00665
272568004904	Integrase core domain; Region: rve_3; pfam13683
272568004905	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568004906	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568004907	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
272568004908	dimerization interface [polypeptide binding]; other site
272568004909	substrate binding pocket [chemical binding]; other site
272568004910	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
272568004911	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568004912	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568004913	active site
272568004914	catalytic tetrad [active]
272568004915	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568004916	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568004917	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
272568004918	putative effector binding pocket; other site
272568004919	putative dimerization interface [polypeptide binding]; other site
272568004920	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
272568004921	RES domain; Region: RES; cl02411
272568004922	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
272568004923	Transposase; Region: HTH_Tnp_1; pfam01527
272568004924	putative transposase OrfB; Reviewed; Region: PHA02517
272568004925	HTH-like domain; Region: HTH_21; pfam13276
272568004926	Integrase core domain; Region: rve; pfam00665
272568004927	Integrase core domain; Region: rve_3; pfam13683
272568004928	classical (c) SDRs; Region: SDR_c; cd05233
272568004929	NAD(P) binding site [chemical binding]; other site
272568004930	active site
272568004931	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
272568004932	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
272568004933	C-terminal domain interface [polypeptide binding]; other site
272568004934	GSH binding site (G-site) [chemical binding]; other site
272568004935	dimer interface [polypeptide binding]; other site
272568004936	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
272568004937	N-terminal domain interface [polypeptide binding]; other site
272568004938	dimer interface [polypeptide binding]; other site
272568004939	substrate binding pocket (H-site) [chemical binding]; other site
272568004940	putative S-transferase; Provisional; Region: PRK11752
272568004941	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
272568004942	C-terminal domain interface [polypeptide binding]; other site
272568004943	GSH binding site (G-site) [chemical binding]; other site
272568004944	dimer interface [polypeptide binding]; other site
272568004945	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
272568004946	dimer interface [polypeptide binding]; other site
272568004947	N-terminal domain interface [polypeptide binding]; other site
272568004948	active site
272568004949	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
272568004950	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
272568004951	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
272568004952	DNA binding residues [nucleotide binding]
272568004953	methionine sulfoxide reductase A; Provisional; Region: PRK13014
272568004954	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
272568004955	SelR domain; Region: SelR; pfam01641
272568004956	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
272568004957	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
272568004958	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
272568004959	Moco binding site; other site
272568004960	metal coordination site [ion binding]; other site
272568004961	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
272568004962	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
272568004963	dimer interface [polypeptide binding]; other site
272568004964	FMN binding site [chemical binding]; other site
272568004965	Pirin-related protein [General function prediction only]; Region: COG1741
272568004966	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568004967	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
272568004968	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568004969	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568004970	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568004971	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
272568004972	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568004973	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568004974	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
272568004975	putative substrate binding pocket [chemical binding]; other site
272568004976	putative dimerization interface [polypeptide binding]; other site
272568004977	Transcriptional regulators [Transcription]; Region: FadR; COG2186
272568004978	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568004979	DNA-binding site [nucleotide binding]; DNA binding site
272568004980	FCD domain; Region: FCD; pfam07729
272568004981	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
272568004982	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
272568004983	putative C-terminal domain interface [polypeptide binding]; other site
272568004984	putative GSH binding site (G-site) [chemical binding]; other site
272568004985	putative dimer interface [polypeptide binding]; other site
272568004986	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
272568004987	putative N-terminal domain interface [polypeptide binding]; other site
272568004988	putative dimer interface [polypeptide binding]; other site
272568004989	putative substrate binding pocket (H-site) [chemical binding]; other site
272568004990	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568004991	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568004992	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
272568004993	putative effector binding pocket; other site
272568004994	dimerization interface [polypeptide binding]; other site
272568004995	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
272568004996	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
272568004997	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
272568004998	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568004999	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568005000	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
272568005001	dimerization interface [polypeptide binding]; other site
272568005002	substrate binding pocket [chemical binding]; other site
272568005003	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
272568005004	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
272568005005	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
272568005006	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
272568005007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005008	putative substrate translocation pore; other site
272568005009	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568005010	putative DNA binding site [nucleotide binding]; other site
272568005011	putative Zn2+ binding site [ion binding]; other site
272568005012	Winged helix-turn helix; Region: HTH_29; pfam13551
272568005013	Winged helix-turn helix; Region: HTH_33; pfam13592
272568005014	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568005015	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568005016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568005017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568005018	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
272568005019	putative substrate binding pocket [chemical binding]; other site
272568005020	putative dimerization interface [polypeptide binding]; other site
272568005021	major facilitator superfamily transporter; Provisional; Region: PRK05122
272568005022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005023	putative substrate translocation pore; other site
272568005024	Transposase; Region: HTH_Tnp_1; pfam01527
272568005025	putative transposase OrfB; Reviewed; Region: PHA02517
272568005026	HTH-like domain; Region: HTH_21; pfam13276
272568005027	Integrase core domain; Region: rve; pfam00665
272568005028	Integrase core domain; Region: rve_3; pfam13683
272568005029	transposase/IS protein; Provisional; Region: PRK09183
272568005030	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568005031	Walker A motif; other site
272568005032	ATP binding site [chemical binding]; other site
272568005033	Winged helix-turn helix; Region: HTH_29; pfam13551
272568005034	Winged helix-turn helix; Region: HTH_33; pfam13592
272568005035	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568005036	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568005037	Winged helix-turn helix; Region: HTH_29; pfam13551
272568005038	Helix-turn-helix domain; Region: HTH_28; pfam13518
272568005039	Integrase core domain; Region: rve; pfam00665
272568005040	Integrase core domain; Region: rve_3; pfam13683
272568005041	Winged helix-turn helix; Region: HTH_29; pfam13551
272568005042	Winged helix-turn helix; Region: HTH_33; pfam13592
272568005043	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568005044	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568005045	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568005046	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005047	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568005048	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
272568005049	Predicted ATPase [General function prediction only]; Region: COG5293
272568005050	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
272568005051	Winged helix-turn helix; Region: HTH_29; pfam13551
272568005052	Winged helix-turn helix; Region: HTH_33; pfam13592
272568005053	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568005054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568005055	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
272568005056	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
272568005057	Walker A motif; other site
272568005058	ATP binding site [chemical binding]; other site
272568005059	Walker B motif; other site
272568005060	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
272568005061	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
272568005062	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
272568005063	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568005064	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
272568005065	dimerization interface [polypeptide binding]; other site
272568005066	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
272568005067	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
272568005068	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
272568005069	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
272568005070	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568005071	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568005072	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568005073	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
272568005074	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
272568005075	Transposase domain (DUF772); Region: DUF772; pfam05598
272568005076	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005077	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568005078	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568005079	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005080	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568005081	Winged helix-turn helix; Region: HTH_29; pfam13551
272568005082	Helix-turn-helix domain; Region: HTH_28; pfam13518
272568005083	Integrase core domain; Region: rve; pfam00665
272568005084	Integrase core domain; Region: rve_3; pfam13683
272568005085	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
272568005086	putative transposase OrfB; Reviewed; Region: PHA02517
272568005087	HTH-like domain; Region: HTH_21; pfam13276
272568005088	Integrase core domain; Region: rve; pfam00665
272568005089	Integrase core domain; Region: rve_3; cl15866
272568005090	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
272568005091	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
272568005092	putative dimer interface [polypeptide binding]; other site
272568005093	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568005094	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005095	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568005096	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
272568005097	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
272568005098	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
272568005099	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
272568005100	catalytic residues [active]
272568005101	catalytic nucleophile [active]
272568005102	Recombinase; Region: Recombinase; pfam07508
272568005103	Transposase, Mutator family; Region: Transposase_mut; pfam00872
272568005104	MULE transposase domain; Region: MULE; pfam10551
272568005105	Transposase; Region: HTH_Tnp_1; pfam01527
272568005106	putative transposase OrfB; Reviewed; Region: PHA02517
272568005107	HTH-like domain; Region: HTH_21; pfam13276
272568005108	Integrase core domain; Region: rve; pfam00665
272568005109	Integrase core domain; Region: rve_3; pfam13683
272568005110	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
272568005111	Clp amino terminal domain; Region: Clp_N; pfam02861
272568005112	Clp amino terminal domain; Region: Clp_N; pfam02861
272568005113	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568005114	Walker A motif; other site
272568005115	ATP binding site [chemical binding]; other site
272568005116	Walker B motif; other site
272568005117	arginine finger; other site
272568005118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568005119	Walker A motif; other site
272568005120	ATP binding site [chemical binding]; other site
272568005121	Walker B motif; other site
272568005122	arginine finger; other site
272568005123	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
272568005124	Domain of unknown function (DUF336); Region: DUF336; cl01249
272568005125	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568005126	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568005127	active site
272568005128	catalytic tetrad [active]
272568005129	LysR family transcriptional regulator; Provisional; Region: PRK14997
272568005130	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568005131	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
272568005132	putative effector binding pocket; other site
272568005133	dimerization interface [polypeptide binding]; other site
272568005134	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568005135	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005136	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
272568005137	Transposase; Region: HTH_Tnp_1; pfam01527
272568005138	putative transposase OrfB; Reviewed; Region: PHA02517
272568005139	HTH-like domain; Region: HTH_21; pfam13276
272568005140	Integrase core domain; Region: rve; pfam00665
272568005141	Integrase core domain; Region: rve_3; pfam13683
272568005142	Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659
272568005143	5' RNA guide strand anchoring site; other site
272568005144	active site
272568005145	Fic family protein [Function unknown]; Region: COG3177
272568005146	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
272568005147	Fic/DOC family; Region: Fic; pfam02661
272568005148	Major royal jelly protein; Region: MRJP; pfam03022
272568005149	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
272568005150	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
272568005151	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
272568005152	shikimate binding site; other site
272568005153	NAD(P) binding site [chemical binding]; other site
272568005154	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
272568005155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005156	putative substrate translocation pore; other site
272568005157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005158	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
272568005159	ATP-NAD kinase; Region: NAD_kinase; pfam01513
272568005160	nitrilase; Region: PLN02798
272568005161	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
272568005162	putative active site [active]
272568005163	catalytic triad [active]
272568005164	dimer interface [polypeptide binding]; other site
272568005165	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
272568005166	Cation efflux family; Region: Cation_efflux; pfam01545
272568005167	phosphoserine phosphatase SerB; Region: serB; TIGR00338
272568005168	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
272568005169	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568005170	motif II; other site
272568005171	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
272568005172	IPP transferase; Region: IPPT; pfam01715
272568005173	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
272568005174	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
272568005175	PYR/PP interface [polypeptide binding]; other site
272568005176	dimer interface [polypeptide binding]; other site
272568005177	TPP binding site [chemical binding]; other site
272568005178	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
272568005179	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
272568005180	TPP-binding site [chemical binding]; other site
272568005181	dimer interface [polypeptide binding]; other site
272568005182	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
272568005183	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
272568005184	putative valine binding site [chemical binding]; other site
272568005185	dimer interface [polypeptide binding]; other site
272568005186	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
272568005187	ketol-acid reductoisomerase; Provisional; Region: PRK05479
272568005188	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
272568005189	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
272568005190	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568005191	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005192	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568005193	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568005194	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005195	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
272568005196	Part of AAA domain; Region: AAA_19; pfam13245
272568005197	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
272568005198	AAA domain; Region: AAA_12; pfam13087
272568005199	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568005200	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005201	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568005202	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
272568005203	TrwC relaxase; Region: TrwC; pfam08751
272568005204	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
272568005205	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
272568005206	Integrase core domain; Region: rve; pfam00665
272568005207	transposase/IS protein; Provisional; Region: PRK09183
272568005208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568005209	Walker A motif; other site
272568005210	ATP binding site [chemical binding]; other site
272568005211	Walker B motif; other site
272568005212	arginine finger; other site
272568005213	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568005214	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005215	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568005216	HTH-like domain; Region: HTH_21; pfam13276
272568005217	Transposase; Region: HTH_Tnp_1; cl17663
272568005218	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
272568005219	active site
272568005220	Int/Topo IB signature motif; other site
272568005221	DNA binding site [nucleotide binding]
272568005222	Protein of unknown function DUF45; Region: DUF45; pfam01863
272568005223	hypothetical protein; Provisional; Region: PRK05170
272568005224	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
272568005225	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
272568005226	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568005227	Walker A/P-loop; other site
272568005228	ATP binding site [chemical binding]; other site
272568005229	Q-loop/lid; other site
272568005230	ABC transporter signature motif; other site
272568005231	Walker B; other site
272568005232	D-loop; other site
272568005233	H-loop/switch region; other site
272568005234	TOBE domain; Region: TOBE_2; pfam08402
272568005235	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
272568005236	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
272568005237	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
272568005238	MarR family; Region: MarR_2; pfam12802
272568005239	Fusaric acid resistance protein family; Region: FUSC; pfam04632
272568005240	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
272568005241	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
272568005242	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
272568005243	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568005244	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568005245	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568005246	Protein of unknown function (DUF563); Region: DUF563; pfam04577
272568005247	Protein of unknown function (DUF563); Region: DUF563; pfam04577
272568005248	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
272568005249	Probable Catalytic site; other site
272568005250	metal-binding site
272568005251	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
272568005252	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
272568005253	Probable Catalytic site; other site
272568005254	metal-binding site
272568005255	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
272568005256	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
272568005257	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
272568005258	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
272568005259	PA/protease or protease-like domain interface [polypeptide binding]; other site
272568005260	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
272568005261	metal binding site [ion binding]; metal-binding site
272568005262	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568005263	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
272568005264	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568005265	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568005266	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
272568005267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005268	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
272568005269	putative phosphoketolase; Provisional; Region: PRK05261
272568005270	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
272568005271	TPP-binding site; other site
272568005272	XFP C-terminal domain; Region: XFP_C; pfam09363
272568005273	Acetokinase family; Region: Acetate_kinase; cl17229
272568005274	propionate/acetate kinase; Provisional; Region: PRK12379
272568005275	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
272568005276	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
272568005277	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
272568005278	Active site cavity [active]
272568005279	catalytic acid [active]
272568005280	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
272568005281	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568005282	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
272568005283	active site lid residues [active]
272568005284	substrate binding pocket [chemical binding]; other site
272568005285	catalytic residues [active]
272568005286	substrate-Mg2+ binding site; other site
272568005287	aspartate-rich region 1; other site
272568005288	aspartate-rich region 2; other site
272568005289	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
272568005290	active site lid residues [active]
272568005291	substrate binding pocket [chemical binding]; other site
272568005292	catalytic residues [active]
272568005293	substrate-Mg2+ binding site; other site
272568005294	aspartate-rich region 1; other site
272568005295	aspartate-rich region 2; other site
272568005296	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
272568005297	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
272568005298	active site
272568005299	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
272568005300	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
272568005301	putative NADP binding site [chemical binding]; other site
272568005302	putative substrate binding site [chemical binding]; other site
272568005303	active site
272568005304	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
272568005305	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
272568005306	prephenate dehydrogenase; Validated; Region: PRK08507
272568005307	malate dehydrogenase; Provisional; Region: PRK13529
272568005308	Malic enzyme, N-terminal domain; Region: malic; pfam00390
272568005309	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
272568005310	NAD(P) binding site [chemical binding]; other site
272568005311	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
272568005312	catalytic core [active]
272568005313	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
272568005314	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
272568005315	substrate binding site; other site
272568005316	tetramer interface; other site
272568005317	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568005318	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568005319	N-terminal plug; other site
272568005320	ligand-binding site [chemical binding]; other site
272568005321	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
272568005322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568005323	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568005324	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568005325	Winged helix-turn helix; Region: HTH_29; pfam13551
272568005326	Homeodomain-like domain; Region: HTH_32; pfam13565
272568005327	Winged helix-turn helix; Region: HTH_33; pfam13592
272568005328	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568005329	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
272568005330	Protein export membrane protein; Region: SecD_SecF; cl14618
272568005331	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
272568005332	Na binding site [ion binding]; other site
272568005333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568005334	short chain dehydrogenase; Provisional; Region: PRK07024
272568005335	NAD(P) binding site [chemical binding]; other site
272568005336	active site
272568005337	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
272568005338	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
272568005339	catalytic site [active]
272568005340	G-X2-G-X-G-K; other site
272568005341	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
272568005342	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
272568005343	putative ribose interaction site [chemical binding]; other site
272568005344	putative ADP binding site [chemical binding]; other site
272568005345	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
272568005346	active site
272568005347	HIGH motif; other site
272568005348	nucleotide binding site [chemical binding]; other site
272568005349	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
272568005350	dimerization interface [polypeptide binding]; other site
272568005351	putative active cleft [active]
272568005352	replicative DNA helicase; Provisional; Region: PRK09165
272568005353	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
272568005354	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
272568005355	Walker A motif; other site
272568005356	ATP binding site [chemical binding]; other site
272568005357	Walker B motif; other site
272568005358	DNA binding loops [nucleotide binding]
272568005359	Uncharacterized conserved protein [Function unknown]; Region: COG1739
272568005360	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
272568005361	DNA repair protein RadA; Provisional; Region: PRK11823
272568005362	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
272568005363	Walker A motif/ATP binding site; other site
272568005364	ATP binding site [chemical binding]; other site
272568005365	Walker B motif; other site
272568005366	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
272568005367	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
272568005368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568005369	Walker A/P-loop; other site
272568005370	ATP binding site [chemical binding]; other site
272568005371	Q-loop/lid; other site
272568005372	ABC transporter signature motif; other site
272568005373	Walker B; other site
272568005374	D-loop; other site
272568005375	H-loop/switch region; other site
272568005376	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
272568005377	Permease; Region: Permease; pfam02405
272568005378	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
272568005379	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
272568005380	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
272568005381	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
272568005382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005383	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
272568005384	putative substrate translocation pore; other site
272568005385	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568005386	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568005387	WHG domain; Region: WHG; pfam13305
272568005388	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
272568005389	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
272568005390	putative molybdopterin cofactor binding site [chemical binding]; other site
272568005391	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
272568005392	putative molybdopterin cofactor binding site; other site
272568005393	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
272568005394	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
272568005395	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
272568005396	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
272568005397	Mechanosensitive ion channel; Region: MS_channel; pfam00924
272568005398	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
272568005399	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
272568005400	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
272568005401	homopentamer interface [polypeptide binding]; other site
272568005402	active site
272568005403	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
272568005404	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
272568005405	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
272568005406	dimerization interface [polypeptide binding]; other site
272568005407	active site
272568005408	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
272568005409	Lumazine binding domain; Region: Lum_binding; pfam00677
272568005410	Lumazine binding domain; Region: Lum_binding; pfam00677
272568005411	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
272568005412	catalytic motif [active]
272568005413	Zn binding site [ion binding]; other site
272568005414	RibD C-terminal domain; Region: RibD_C; cl17279
272568005415	Predicted small secreted protein [Function unknown]; Region: COG5510
272568005416	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
272568005417	Na binding site [ion binding]; other site
272568005418	Beta-lactamase; Region: Beta-lactamase; pfam00144
272568005419	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
272568005420	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
272568005421	CoenzymeA binding site [chemical binding]; other site
272568005422	subunit interaction site [polypeptide binding]; other site
272568005423	PHB binding site; other site
272568005424	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
272568005425	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
272568005426	active site
272568005427	catalytic residues [active]
272568005428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005429	D-galactonate transporter; Region: 2A0114; TIGR00893
272568005430	putative substrate translocation pore; other site
272568005431	Winged helix-turn helix; Region: HTH_29; pfam13551
272568005432	Integrase core domain; Region: rve; pfam00665
272568005433	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
272568005434	Integrase core domain; Region: rve_3; pfam13683
272568005435	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
272568005436	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568005437	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
272568005438	active site
272568005439	Zn binding site [ion binding]; other site
272568005440	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
272568005441	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
272568005442	active site
272568005443	metal binding site [ion binding]; metal-binding site
272568005444	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
272568005445	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
272568005446	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
272568005447	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568005448	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
272568005449	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568005450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568005451	PAS domain; Region: PAS_9; pfam13426
272568005452	putative active site [active]
272568005453	heme pocket [chemical binding]; other site
272568005454	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568005455	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568005456	metal binding site [ion binding]; metal-binding site
272568005457	active site
272568005458	I-site; other site
272568005459	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568005460	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
272568005461	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
272568005462	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
272568005463	putative active site [active]
272568005464	putative substrate binding site [chemical binding]; other site
272568005465	putative cosubstrate binding site; other site
272568005466	catalytic site [active]
272568005467	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
272568005468	NMT1/THI5 like; Region: NMT1; pfam09084
272568005469	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
272568005470	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
272568005471	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
272568005472	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
272568005473	Ligand binding site; other site
272568005474	Putative Catalytic site; other site
272568005475	DXD motif; other site
272568005476	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
272568005477	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
272568005478	ATP synthase subunit C; Region: ATP-synt_C; cl00466
272568005479	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
272568005480	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
272568005481	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
272568005482	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
272568005483	purine monophosphate binding site [chemical binding]; other site
272568005484	dimer interface [polypeptide binding]; other site
272568005485	putative catalytic residues [active]
272568005486	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
272568005487	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
272568005488	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
272568005489	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
272568005490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568005491	catalytic residue [active]
272568005492	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
272568005493	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
272568005494	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
272568005495	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
272568005496	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
272568005497	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
272568005498	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
272568005499	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
272568005500	dimerization domain swap beta strand [polypeptide binding]; other site
272568005501	regulatory protein interface [polypeptide binding]; other site
272568005502	active site
272568005503	regulatory phosphorylation site [posttranslational modification]; other site
272568005504	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
272568005505	active pocket/dimerization site; other site
272568005506	active site
272568005507	phosphorylation site [posttranslational modification]
272568005508	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
272568005509	shikimate kinase; Reviewed; Region: aroK; PRK00131
272568005510	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
272568005511	Hpr binding site; other site
272568005512	active site
272568005513	homohexamer subunit interaction site [polypeptide binding]; other site
272568005514	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
272568005515	homotrimer interaction site [polypeptide binding]; other site
272568005516	putative active site [active]
272568005517	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
272568005518	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568005519	Walker A/P-loop; other site
272568005520	ATP binding site [chemical binding]; other site
272568005521	Q-loop/lid; other site
272568005522	ABC transporter signature motif; other site
272568005523	Walker B; other site
272568005524	D-loop; other site
272568005525	H-loop/switch region; other site
272568005526	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
272568005527	Histidine kinase; Region: HisKA_3; pfam07730
272568005528	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
272568005529	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
272568005530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568005531	active site
272568005532	phosphorylation site [posttranslational modification]
272568005533	intermolecular recognition site; other site
272568005534	dimerization interface [polypeptide binding]; other site
272568005535	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
272568005536	DNA binding residues [nucleotide binding]
272568005537	dimerization interface [polypeptide binding]; other site
272568005538	hypothetical protein; Provisional; Region: PRK02853
272568005539	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
272568005540	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
272568005541	putative ligand binding site [chemical binding]; other site
272568005542	NAD binding site [chemical binding]; other site
272568005543	catalytic site [active]
272568005544	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
272568005545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005546	metabolite-proton symporter; Region: 2A0106; TIGR00883
272568005547	putative substrate translocation pore; other site
272568005548	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
272568005549	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
272568005550	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
272568005551	hypothetical protein; Provisional; Region: PRK02487
272568005552	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
272568005553	putative NAD(P) binding site [chemical binding]; other site
272568005554	catalytic Zn binding site [ion binding]; other site
272568005555	Protein of unknown function (DUF2501); Region: DUF2501; pfam10696
272568005556	YGGT family; Region: YGGT; pfam02325
272568005557	hypothetical protein; Provisional; Region: PRK09272
272568005558	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
272568005559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
272568005560	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
272568005561	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
272568005562	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
272568005563	active site
272568005564	catalytic residues [active]
272568005565	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
272568005566	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
272568005567	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
272568005568	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
272568005569	substrate binding site [chemical binding]; other site
272568005570	active site
272568005571	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
272568005572	Maf-like protein; Provisional; Region: PRK14361
272568005573	putative active site [active]
272568005574	FtsX-like permease family; Region: FtsX; pfam02687
272568005575	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
272568005576	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
272568005577	Walker A/P-loop; other site
272568005578	ATP binding site [chemical binding]; other site
272568005579	Q-loop/lid; other site
272568005580	ABC transporter signature motif; other site
272568005581	Walker B; other site
272568005582	D-loop; other site
272568005583	H-loop/switch region; other site
272568005584	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
272568005585	active site
272568005586	catalytic triad [active]
272568005587	oxyanion hole [active]
272568005588	switch loop; other site
272568005589	Predicted membrane protein [Function unknown]; Region: COG2259
272568005590	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568005591	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568005592	N-terminal plug; other site
272568005593	ligand-binding site [chemical binding]; other site
272568005594	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
272568005595	ParB-like nuclease domain; Region: ParB; smart00470
272568005596	KorB domain; Region: KorB; pfam08535
272568005597	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
272568005598	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
272568005599	P-loop; other site
272568005600	Magnesium ion binding site [ion binding]; other site
272568005601	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
272568005602	Magnesium ion binding site [ion binding]; other site
272568005603	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
272568005604	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
272568005605	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
272568005606	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
272568005607	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
272568005608	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
272568005609	trmE is a tRNA modification GTPase; Region: trmE; cd04164
272568005610	G1 box; other site
272568005611	GTP/Mg2+ binding site [chemical binding]; other site
272568005612	Switch I region; other site
272568005613	G2 box; other site
272568005614	Switch II region; other site
272568005615	G3 box; other site
272568005616	G4 box; other site
272568005617	G5 box; other site
272568005618	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
272568005619	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
272568005620	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
272568005621	DNA binding site [nucleotide binding]
272568005622	active site
272568005623	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
272568005624	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
272568005625	NADP binding site [chemical binding]; other site
272568005626	dimer interface [polypeptide binding]; other site
272568005627	short chain dehydrogenase; Provisional; Region: PRK06197
272568005628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568005629	NAD(P) binding site [chemical binding]; other site
272568005630	active site
272568005631	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
272568005632	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
272568005633	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
272568005634	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
272568005635	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
272568005636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568005637	active site
272568005638	phosphorylation site [posttranslational modification]
272568005639	intermolecular recognition site; other site
272568005640	dimerization interface [polypeptide binding]; other site
272568005641	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
272568005642	DNA binding residues [nucleotide binding]
272568005643	dimerization interface [polypeptide binding]; other site
272568005644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568005645	dimer interface [polypeptide binding]; other site
272568005646	phosphorylation site [posttranslational modification]
272568005647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568005648	ATP binding site [chemical binding]; other site
272568005649	Mg2+ binding site [ion binding]; other site
272568005650	G-X-G motif; other site
272568005651	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
272568005652	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568005653	N-terminal plug; other site
272568005654	ligand-binding site [chemical binding]; other site
272568005655	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
272568005656	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568005657	Sel1-like repeats; Region: SEL1; smart00671
272568005658	Sel1-like repeats; Region: SEL1; smart00671
272568005659	Sel1-like repeats; Region: SEL1; smart00671
272568005660	beta-ketothiolase; Provisional; Region: PRK09051
272568005661	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
272568005662	dimer interface [polypeptide binding]; other site
272568005663	active site
272568005664	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
272568005665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005666	putative substrate translocation pore; other site
272568005667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005668	hypothetical protein; Validated; Region: PRK00029
272568005669	Uncharacterized conserved protein [Function unknown]; Region: COG0397
272568005670	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
272568005671	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
272568005672	substrate binding site [chemical binding]; other site
272568005673	oxyanion hole (OAH) forming residues; other site
272568005674	trimer interface [polypeptide binding]; other site
272568005675	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
272568005676	Flavin Reductases; Region: FlaRed; cl00801
272568005677	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
272568005678	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
272568005679	ABC-ATPase subunit  interface; other site
272568005680	dimer interface [polypeptide binding]; other site
272568005681	putative PBP binding regions; other site
272568005682	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
272568005683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568005684	Walker A/P-loop; other site
272568005685	ATP binding site [chemical binding]; other site
272568005686	Q-loop/lid; other site
272568005687	ABC transporter signature motif; other site
272568005688	Walker B; other site
272568005689	D-loop; other site
272568005690	H-loop/switch region; other site
272568005691	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
272568005692	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
272568005693	intersubunit interface [polypeptide binding]; other site
272568005694	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
272568005695	metal binding site 2 [ion binding]; metal-binding site
272568005696	putative DNA binding helix; other site
272568005697	metal binding site 1 [ion binding]; metal-binding site
272568005698	dimer interface [polypeptide binding]; other site
272568005699	structural Zn2+ binding site [ion binding]; other site
272568005700	L-asparaginase II; Region: Asparaginase_II; pfam06089
272568005701	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
272568005702	active site
272568005703	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
272568005704	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
272568005705	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
272568005706	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
272568005707	substrate binding site [chemical binding]; other site
272568005708	active site
272568005709	catalytic residues [active]
272568005710	heterodimer interface [polypeptide binding]; other site
272568005711	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
272568005712	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
272568005713	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568005714	catalytic residue [active]
272568005715	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
272568005716	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
272568005717	Cl binding site [ion binding]; other site
272568005718	oligomer interface [polypeptide binding]; other site
272568005719	transcription termination factor Rho; Provisional; Region: rho; PRK09376
272568005720	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
272568005721	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
272568005722	RNA binding site [nucleotide binding]; other site
272568005723	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
272568005724	multimer interface [polypeptide binding]; other site
272568005725	Walker A motif; other site
272568005726	ATP binding site [chemical binding]; other site
272568005727	Walker B motif; other site
272568005728	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
272568005729	S-adenosylmethionine synthetase; Validated; Region: PRK05250
272568005730	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
272568005731	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
272568005732	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
272568005733	dihydrodipicolinate reductase; Provisional; Region: PRK00048
272568005734	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
272568005735	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
272568005736	chaperone protein DnaJ; Provisional; Region: PRK10767
272568005737	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
272568005738	HSP70 interaction site [polypeptide binding]; other site
272568005739	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
272568005740	Zn binding sites [ion binding]; other site
272568005741	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
272568005742	dimer interface [polypeptide binding]; other site
272568005743	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
272568005744	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
272568005745	nucleotide binding site [chemical binding]; other site
272568005746	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
272568005747	heat shock protein GrpE; Provisional; Region: PRK14141
272568005748	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
272568005749	dimer interface [polypeptide binding]; other site
272568005750	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
272568005751	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568005752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568005753	active site
272568005754	phosphorylation site [posttranslational modification]
272568005755	intermolecular recognition site; other site
272568005756	dimerization interface [polypeptide binding]; other site
272568005757	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568005758	DNA binding site [nucleotide binding]
272568005759	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
272568005760	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
272568005761	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
272568005762	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568005763	dimer interface [polypeptide binding]; other site
272568005764	phosphorylation site [posttranslational modification]
272568005765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568005766	ATP binding site [chemical binding]; other site
272568005767	Mg2+ binding site [ion binding]; other site
272568005768	G-X-G motif; other site
272568005769	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568005770	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568005771	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
272568005772	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568005773	FeS/SAM binding site; other site
272568005774	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
272568005775	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
272568005776	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
272568005777	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
272568005778	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
272568005779	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
272568005780	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
272568005781	Domain of unknown function DUF20; Region: UPF0118; pfam01594
272568005782	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
272568005783	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
272568005784	ligand binding site [chemical binding]; other site
272568005785	flexible hinge region; other site
272568005786	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
272568005787	putative switch regulator; other site
272568005788	non-specific DNA interactions [nucleotide binding]; other site
272568005789	DNA binding site [nucleotide binding]
272568005790	sequence specific DNA binding site [nucleotide binding]; other site
272568005791	putative cAMP binding site [chemical binding]; other site
272568005792	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
272568005793	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
272568005794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
272568005795	FeS/SAM binding site; other site
272568005796	HemN C-terminal domain; Region: HemN_C; pfam06969
272568005797	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
272568005798	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
272568005799	hydroxyglutarate oxidase; Provisional; Region: PRK11728
272568005800	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
272568005801	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
272568005802	Ligand binding site [chemical binding]; other site
272568005803	Electron transfer flavoprotein domain; Region: ETF; pfam01012
272568005804	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
272568005805	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
272568005806	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
272568005807	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
272568005808	putative efflux protein, MATE family; Region: matE; TIGR00797
272568005809	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568005810	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568005811	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
272568005812	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568005813	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
272568005814	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568005815	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
272568005816	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
272568005817	NAD binding site [chemical binding]; other site
272568005818	catalytic residues [active]
272568005819	substrate binding site [chemical binding]; other site
272568005820	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
272568005821	pyruvate kinase; Provisional; Region: PRK06247
272568005822	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
272568005823	domain interfaces; other site
272568005824	active site
272568005825	Bacterial SH3 domain; Region: SH3_4; pfam06347
272568005826	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
272568005827	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
272568005828	ATP binding site [chemical binding]; other site
272568005829	substrate interface [chemical binding]; other site
272568005830	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
272568005831	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
272568005832	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
272568005833	active site
272568005834	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
272568005835	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
272568005836	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
272568005837	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
272568005838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
272568005839	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
272568005840	RNA binding surface [nucleotide binding]; other site
272568005841	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
272568005842	pseudouridine synthase; Region: TIGR00093
272568005843	active site
272568005844	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
272568005845	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
272568005846	catalytic triad [active]
272568005847	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
272568005848	nucleoside/Zn binding site; other site
272568005849	dimer interface [polypeptide binding]; other site
272568005850	catalytic motif [active]
272568005851	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
272568005852	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
272568005853	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
272568005854	protein binding site [polypeptide binding]; other site
272568005855	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
272568005856	protein binding site [polypeptide binding]; other site
272568005857	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568005858	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
272568005859	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568005860	catalytic residue [active]
272568005861	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
272568005862	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
272568005863	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
272568005864	homodimer interface [polypeptide binding]; other site
272568005865	NADP binding site [chemical binding]; other site
272568005866	substrate binding site [chemical binding]; other site
272568005867	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
272568005868	FAD binding site [chemical binding]; other site
272568005869	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
272568005870	Zn binding site [ion binding]; other site
272568005871	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
272568005872	dimer interface [polypeptide binding]; other site
272568005873	ADP-ribose binding site [chemical binding]; other site
272568005874	active site
272568005875	nudix motif; other site
272568005876	metal binding site [ion binding]; metal-binding site
272568005877	major facilitator superfamily transporter; Provisional; Region: PRK05122
272568005878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005879	putative substrate translocation pore; other site
272568005880	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
272568005881	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
272568005882	Protein of unknown function (DUF563); Region: DUF563; pfam04577
272568005883	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
272568005884	Na binding site [ion binding]; other site
272568005885	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
272568005886	pyruvate phosphate dikinase; Provisional; Region: PRK09279
272568005887	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
272568005888	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
272568005889	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
272568005890	PEP synthetase regulatory protein; Provisional; Region: PRK05339
272568005891	ferrochelatase; Reviewed; Region: hemH; PRK00035
272568005892	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
272568005893	C-terminal domain interface [polypeptide binding]; other site
272568005894	active site
272568005895	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
272568005896	active site
272568005897	N-terminal domain interface [polypeptide binding]; other site
272568005898	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
272568005899	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
272568005900	minor groove reading motif; other site
272568005901	helix-hairpin-helix signature motif; other site
272568005902	substrate binding pocket [chemical binding]; other site
272568005903	active site
272568005904	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
272568005905	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
272568005906	DNA binding and oxoG recognition site [nucleotide binding]
272568005907	Protein of unknown function (DUF721); Region: DUF721; pfam05258
272568005908	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
272568005909	active site
272568005910	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
272568005911	active site
272568005912	dimer interface [polypeptide binding]; other site
272568005913	hypothetical protein; Validated; Region: PRK09104
272568005914	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
272568005915	metal binding site [ion binding]; metal-binding site
272568005916	putative dimer interface [polypeptide binding]; other site
272568005917	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
272568005918	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
272568005919	pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265
272568005920	active site
272568005921	hydrophilic channel; other site
272568005922	dimerization interface [polypeptide binding]; other site
272568005923	catalytic residues [active]
272568005924	active site lid [active]
272568005925	protease TldD; Provisional; Region: tldD; PRK10735
272568005926	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
272568005927	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568005928	N-terminal plug; other site
272568005929	ligand-binding site [chemical binding]; other site
272568005930	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568005931	Sel1-like repeats; Region: SEL1; smart00671
272568005932	Trehalase; Region: Trehalase; cl17346
272568005933	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
272568005934	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
272568005935	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
272568005936	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568005937	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
272568005938	putative substrate translocation pore; other site
272568005939	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
272568005940	active site
272568005941	Fusaric acid resistance protein family; Region: FUSC; pfam04632
272568005942	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
272568005943	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
272568005944	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
272568005945	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
272568005946	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
272568005947	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
272568005948	carboxyltransferase (CT) interaction site; other site
272568005949	biotinylation site [posttranslational modification]; other site
272568005950	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
272568005951	Dehydroquinase class II; Region: DHquinase_II; pfam01220
272568005952	trimer interface [polypeptide binding]; other site
272568005953	active site
272568005954	dimer interface [polypeptide binding]; other site
272568005955	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
272568005956	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
272568005957	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
272568005958	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
272568005959	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
272568005960	dimer interface [polypeptide binding]; other site
272568005961	active site
272568005962	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
272568005963	catalytic residues [active]
272568005964	substrate binding site [chemical binding]; other site
272568005965	CcmB protein; Region: CcmB; cl17444
272568005966	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
272568005967	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568005968	Walker A/P-loop; other site
272568005969	ATP binding site [chemical binding]; other site
272568005970	Q-loop/lid; other site
272568005971	ABC transporter signature motif; other site
272568005972	Walker B; other site
272568005973	D-loop; other site
272568005974	H-loop/switch region; other site
272568005975	aconitate hydratase; Validated; Region: PRK09277
272568005976	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
272568005977	substrate binding site [chemical binding]; other site
272568005978	ligand binding site [chemical binding]; other site
272568005979	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
272568005980	substrate binding site [chemical binding]; other site
272568005981	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
272568005982	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568005983	Walker A/P-loop; other site
272568005984	ATP binding site [chemical binding]; other site
272568005985	Q-loop/lid; other site
272568005986	ABC transporter signature motif; other site
272568005987	Walker B; other site
272568005988	D-loop; other site
272568005989	H-loop/switch region; other site
272568005990	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
272568005991	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
272568005992	substrate binding pocket [chemical binding]; other site
272568005993	membrane-bound complex binding site; other site
272568005994	hinge residues; other site
272568005995	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
272568005996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568005997	dimer interface [polypeptide binding]; other site
272568005998	conserved gate region; other site
272568005999	putative PBP binding loops; other site
272568006000	ABC-ATPase subunit interface; other site
272568006001	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568006002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006003	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
272568006004	putative effector binding pocket; other site
272568006005	dimerization interface [polypeptide binding]; other site
272568006006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568006007	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
272568006008	Walker A motif; other site
272568006009	ATP binding site [chemical binding]; other site
272568006010	Walker B motif; other site
272568006011	arginine finger; other site
272568006012	ribosome maturation protein RimP; Reviewed; Region: PRK00092
272568006013	Sm and related proteins; Region: Sm_like; cl00259
272568006014	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
272568006015	putative oligomer interface [polypeptide binding]; other site
272568006016	putative RNA binding site [nucleotide binding]; other site
272568006017	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
272568006018	NusA N-terminal domain; Region: NusA_N; pfam08529
272568006019	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
272568006020	RNA binding site [nucleotide binding]; other site
272568006021	homodimer interface [polypeptide binding]; other site
272568006022	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
272568006023	G-X-X-G motif; other site
272568006024	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
272568006025	G-X-X-G motif; other site
272568006026	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
272568006027	hypothetical protein; Provisional; Region: PRK09190
272568006028	Protein of unknown function (DUF448); Region: DUF448; pfam04296
272568006029	putative RNA binding cleft [nucleotide binding]; other site
272568006030	Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358
272568006031	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
272568006032	translation initiation factor IF-2; Region: IF-2; TIGR00487
272568006033	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
272568006034	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
272568006035	G1 box; other site
272568006036	putative GEF interaction site [polypeptide binding]; other site
272568006037	GTP/Mg2+ binding site [chemical binding]; other site
272568006038	Switch I region; other site
272568006039	G2 box; other site
272568006040	G3 box; other site
272568006041	Switch II region; other site
272568006042	G4 box; other site
272568006043	G5 box; other site
272568006044	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
272568006045	Translation-initiation factor 2; Region: IF-2; pfam11987
272568006046	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
272568006047	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
272568006048	mce related protein; Region: MCE; pfam02470
272568006049	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
272568006050	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
272568006051	RNA binding site [nucleotide binding]; other site
272568006052	active site
272568006053	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
272568006054	16S/18S rRNA binding site [nucleotide binding]; other site
272568006055	S13e-L30e interaction site [polypeptide binding]; other site
272568006056	25S rRNA binding site [nucleotide binding]; other site
272568006057	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
272568006058	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
272568006059	RNase E interface [polypeptide binding]; other site
272568006060	trimer interface [polypeptide binding]; other site
272568006061	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
272568006062	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
272568006063	RNase E interface [polypeptide binding]; other site
272568006064	trimer interface [polypeptide binding]; other site
272568006065	active site
272568006066	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
272568006067	putative nucleic acid binding region [nucleotide binding]; other site
272568006068	G-X-X-G motif; other site
272568006069	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
272568006070	RNA binding site [nucleotide binding]; other site
272568006071	domain interface; other site
272568006072	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
272568006073	FMN binding site [chemical binding]; other site
272568006074	substrate binding site [chemical binding]; other site
272568006075	putative catalytic residue [active]
272568006076	Cupin domain; Region: Cupin_2; cl17218
272568006077	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568006078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006079	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
272568006080	putative effector binding pocket; other site
272568006081	dimerization interface [polypeptide binding]; other site
272568006082	Aspartyl protease; Region: Asp_protease_2; pfam13650
272568006083	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
272568006084	protein binding site [polypeptide binding]; other site
272568006085	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
272568006086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568006087	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
272568006088	active site
272568006089	dimerization interface [polypeptide binding]; other site
272568006090	ribonuclease PH; Reviewed; Region: rph; PRK00173
272568006091	Ribonuclease PH; Region: RNase_PH_bact; cd11362
272568006092	hexamer interface [polypeptide binding]; other site
272568006093	active site
272568006094	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
272568006095	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568006096	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568006097	active site
272568006098	catalytic tetrad [active]
272568006099	Transglycosylase; Region: Transgly; pfam00912
272568006100	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
272568006101	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
272568006102	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
272568006103	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
272568006104	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
272568006105	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
272568006106	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
272568006107	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568006108	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568006109	active site
272568006110	phosphorylation site [posttranslational modification]
272568006111	intermolecular recognition site; other site
272568006112	dimerization interface [polypeptide binding]; other site
272568006113	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
272568006114	DNA binding site [nucleotide binding]
272568006115	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
272568006116	dimerization interface [polypeptide binding]; other site
272568006117	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568006118	ATP binding site [chemical binding]; other site
272568006119	Mg2+ binding site [ion binding]; other site
272568006120	G-X-G motif; other site
272568006121	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
272568006122	active site
272568006123	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
272568006124	Trp docking motif [polypeptide binding]; other site
272568006125	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
272568006126	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
272568006127	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
272568006128	putative FMN binding site [chemical binding]; other site
272568006129	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
272568006130	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
272568006131	Coenzyme A binding pocket [chemical binding]; other site
272568006132	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
272568006133	CPxP  motif; other site
272568006134	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
272568006135	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
272568006136	metal binding site 2 [ion binding]; metal-binding site
272568006137	putative DNA binding helix; other site
272568006138	metal binding site 1 [ion binding]; metal-binding site
272568006139	dimer interface [polypeptide binding]; other site
272568006140	structural Zn2+ binding site [ion binding]; other site
272568006141	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
272568006142	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
272568006143	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
272568006144	putative active site [active]
272568006145	catalytic triad [active]
272568006146	putative dimer interface [polypeptide binding]; other site
272568006147	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568006148	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568006149	non-specific DNA binding site [nucleotide binding]; other site
272568006150	salt bridge; other site
272568006151	sequence-specific DNA binding site [nucleotide binding]; other site
272568006152	Putative phosphatase (DUF442); Region: DUF442; cl17385
272568006153	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
272568006154	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
272568006155	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
272568006156	L-aspartate oxidase; Provisional; Region: PRK06175
272568006157	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
272568006158	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
272568006159	putative SdhC subunit interface [polypeptide binding]; other site
272568006160	putative proximal heme binding site [chemical binding]; other site
272568006161	putative Iron-sulfur protein interface [polypeptide binding]; other site
272568006162	putative proximal quinone binding site; other site
272568006163	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
272568006164	Iron-sulfur protein interface; other site
272568006165	proximal quinone binding site [chemical binding]; other site
272568006166	SdhD (CybS) interface [polypeptide binding]; other site
272568006167	proximal heme binding site [chemical binding]; other site
272568006168	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
272568006169	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
272568006170	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
272568006171	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
272568006172	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
272568006173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568006174	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568006175	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568006176	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
272568006177	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
272568006178	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
272568006179	Predicted ATPase [General function prediction only]; Region: COG1485
272568006180	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
272568006181	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
272568006182	TPP-binding site [chemical binding]; other site
272568006183	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
272568006184	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
272568006185	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
272568006186	E3 interaction surface; other site
272568006187	lipoyl attachment site [posttranslational modification]; other site
272568006188	e3 binding domain; Region: E3_binding; pfam02817
272568006189	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
272568006190	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
272568006191	E3 interaction surface; other site
272568006192	lipoyl attachment site [posttranslational modification]; other site
272568006193	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
272568006194	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
272568006195	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568006196	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
272568006197	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
272568006198	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
272568006199	catalytic triad [active]
272568006200	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
272568006201	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568006202	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568006203	catalytic residue [active]
272568006204	Sporulation related domain; Region: SPOR; pfam05036
272568006205	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
272568006206	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
272568006207	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
272568006208	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
272568006209	oligomer interface [polypeptide binding]; other site
272568006210	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
272568006211	nucleoside/Zn binding site; other site
272568006212	dimer interface [polypeptide binding]; other site
272568006213	catalytic motif [active]
272568006214	xanthine permease; Region: pbuX; TIGR03173
272568006215	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
272568006216	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
272568006217	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
272568006218	homotetramer interface [polypeptide binding]; other site
272568006219	ligand binding site [chemical binding]; other site
272568006220	catalytic site [active]
272568006221	NAD binding site [chemical binding]; other site
272568006222	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
272568006223	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
272568006224	active site
272568006225	dimer interface [polypeptide binding]; other site
272568006226	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
272568006227	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
272568006228	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568006229	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568006230	Domain of unknown function (DUF329); Region: DUF329; pfam03884
272568006231	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
272568006232	RNA binding site [nucleotide binding]; other site
272568006233	Maf-like protein; Region: Maf; pfam02545
272568006234	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
272568006235	active site
272568006236	dimer interface [polypeptide binding]; other site
272568006237	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
272568006238	rRNA binding site [nucleotide binding]; other site
272568006239	predicted 30S ribosome binding site; other site
272568006240	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
272568006241	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
272568006242	NAD binding site [chemical binding]; other site
272568006243	dimerization interface [polypeptide binding]; other site
272568006244	product binding site; other site
272568006245	substrate binding site [chemical binding]; other site
272568006246	zinc binding site [ion binding]; other site
272568006247	catalytic residues [active]
272568006248	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
272568006249	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
272568006250	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
272568006251	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
272568006252	hinge; other site
272568006253	active site
272568006254	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
272568006255	trimer interface [polypeptide binding]; other site
272568006256	active site
272568006257	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
272568006258	putative ADP-binding pocket [chemical binding]; other site
272568006259	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568006260	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568006261	binding surface
272568006262	TPR motif; other site
272568006263	Tetratricopeptide repeat; Region: TPR_9; pfam13371
272568006264	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
272568006265	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
272568006266	putative active site [active]
272568006267	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
272568006268	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
272568006269	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
272568006270	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
272568006271	active site
272568006272	dimer interface [polypeptide binding]; other site
272568006273	motif 1; other site
272568006274	motif 2; other site
272568006275	motif 3; other site
272568006276	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
272568006277	anticodon binding site; other site
272568006278	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
272568006279	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
272568006280	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
272568006281	Predicted acetyltransferase [General function prediction only]; Region: COG3393
272568006282	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
272568006283	Coenzyme A binding pocket [chemical binding]; other site
272568006284	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
272568006285	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
272568006286	Protein of unknown function (DUF541); Region: SIMPL; cl01077
272568006287	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
272568006288	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
272568006289	dimerization interface [polypeptide binding]; other site
272568006290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568006291	dimer interface [polypeptide binding]; other site
272568006292	phosphorylation site [posttranslational modification]
272568006293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568006294	ATP binding site [chemical binding]; other site
272568006295	Mg2+ binding site [ion binding]; other site
272568006296	G-X-G motif; other site
272568006297	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568006298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568006299	active site
272568006300	phosphorylation site [posttranslational modification]
272568006301	intermolecular recognition site; other site
272568006302	dimerization interface [polypeptide binding]; other site
272568006303	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568006304	DNA binding site [nucleotide binding]
272568006305	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
272568006306	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
272568006307	protein binding site [polypeptide binding]; other site
272568006308	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
272568006309	ATP binding site [chemical binding]; other site
272568006310	putative Mg++ binding site [ion binding]; other site
272568006311	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
272568006312	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
272568006313	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
272568006314	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
272568006315	DsbD alpha interface [polypeptide binding]; other site
272568006316	catalytic residues [active]
272568006317	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
272568006318	dimerization interface [polypeptide binding]; other site
272568006319	domain crossover interface; other site
272568006320	redox-dependent activation switch; other site
272568006321	ornithine carbamoyltransferase; Provisional; Region: PRK00779
272568006322	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
272568006323	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
272568006324	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
272568006325	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
272568006326	inhibitor-cofactor binding pocket; inhibition site
272568006327	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568006328	catalytic residue [active]
272568006329	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
272568006330	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
272568006331	Peptidase family M1; Region: Peptidase_M1; pfam01433
272568006332	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
272568006333	Zn binding site [ion binding]; other site
272568006334	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
272568006335	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
272568006336	Ligand Binding Site [chemical binding]; other site
272568006337	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568006338	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568006339	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
272568006340	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
272568006341	putative ligand binding site [chemical binding]; other site
272568006342	NAD binding site [chemical binding]; other site
272568006343	dimerization interface [polypeptide binding]; other site
272568006344	catalytic site [active]
272568006345	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
272568006346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568006347	Walker A/P-loop; other site
272568006348	ATP binding site [chemical binding]; other site
272568006349	Q-loop/lid; other site
272568006350	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568006351	ABC transporter signature motif; other site
272568006352	Walker B; other site
272568006353	D-loop; other site
272568006354	ABC transporter; Region: ABC_tran_2; pfam12848
272568006355	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568006356	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
272568006357	EamA-like transporter family; Region: EamA; pfam00892
272568006358	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
272568006359	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568006360	Mg2+ binding site [ion binding]; other site
272568006361	G-X-G motif; other site
272568006362	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
272568006363	anchoring element; other site
272568006364	dimer interface [polypeptide binding]; other site
272568006365	ATP binding site [chemical binding]; other site
272568006366	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
272568006367	active site
272568006368	putative metal-binding site [ion binding]; other site
272568006369	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
272568006370	Transcriptional regulator; Region: Rrf2; pfam02082
272568006371	Predicted transcriptional regulator [Transcription]; Region: COG1959
272568006372	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
272568006373	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
272568006374	dimer interface [polypeptide binding]; other site
272568006375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568006376	catalytic residue [active]
272568006377	YceI-like domain; Region: YceI; pfam04264
272568006378	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
272568006379	Uncharacterized conserved protein [Function unknown]; Region: COG2353
272568006380	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
272568006381	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
272568006382	Uncharacterized conserved protein [Function unknown]; Region: COG1359
272568006383	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
272568006384	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
272568006385	putative ligand binding site [chemical binding]; other site
272568006386	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
272568006387	nucleotide binding site [chemical binding]; other site
272568006388	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
272568006389	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
272568006390	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
272568006391	Uncharacterized conserved protein [Function unknown]; Region: COG3347
272568006392	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
272568006393	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
272568006394	nucleotide binding site [chemical binding]; other site
272568006395	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
272568006396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568006397	active site
272568006398	motif I; other site
272568006399	motif II; other site
272568006400	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568006401	motif II; other site
272568006402	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568006403	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568006404	TM-ABC transporter signature motif; other site
272568006405	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568006406	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568006407	TM-ABC transporter signature motif; other site
272568006408	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
272568006409	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
272568006410	Walker A/P-loop; other site
272568006411	ATP binding site [chemical binding]; other site
272568006412	Q-loop/lid; other site
272568006413	ABC transporter signature motif; other site
272568006414	Walker B; other site
272568006415	D-loop; other site
272568006416	H-loop/switch region; other site
272568006417	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
272568006418	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
272568006419	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
272568006420	ligand binding site [chemical binding]; other site
272568006421	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
272568006422	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
272568006423	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
272568006424	PAS domain; Region: PAS_9; pfam13426
272568006425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568006426	putative active site [active]
272568006427	heme pocket [chemical binding]; other site
272568006428	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568006429	PAS domain; Region: PAS_9; pfam13426
272568006430	putative active site [active]
272568006431	heme pocket [chemical binding]; other site
272568006432	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
272568006433	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
272568006434	dimer interface [polypeptide binding]; other site
272568006435	putative CheW interface [polypeptide binding]; other site
272568006436	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
272568006437	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568006438	binding surface
272568006439	TPR motif; other site
272568006440	TPR repeat; Region: TPR_11; pfam13414
272568006441	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568006442	binding surface
272568006443	TPR motif; other site
272568006444	TPR repeat; Region: TPR_11; pfam13414
272568006445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
272568006446	binding surface
272568006447	TPR motif; other site
272568006448	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
272568006449	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568006450	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006451	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
272568006452	dimerization interface [polypeptide binding]; other site
272568006453	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
272568006454	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
272568006455	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
272568006456	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
272568006457	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
272568006458	homodimer interface [polypeptide binding]; other site
272568006459	active site
272568006460	FMN binding site [chemical binding]; other site
272568006461	substrate binding site [chemical binding]; other site
272568006462	4Fe-4S binding domain; Region: Fer4; cl02805
272568006463	4Fe-4S binding domain; Region: Fer4; pfam00037
272568006464	Protein required for attachment to host cells; Region: Host_attach; pfam10116
272568006465	FOG: CBS domain [General function prediction only]; Region: COG0517
272568006466	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
272568006467	BON domain; Region: BON; pfam04972
272568006468	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
272568006469	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
272568006470	Multicopper oxidase; Region: Cu-oxidase; pfam00394
272568006471	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
272568006472	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
272568006473	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568006474	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568006475	putative substrate translocation pore; other site
272568006476	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
272568006477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568006478	dimer interface [polypeptide binding]; other site
272568006479	phosphorylation site [posttranslational modification]
272568006480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568006481	ATP binding site [chemical binding]; other site
272568006482	Mg2+ binding site [ion binding]; other site
272568006483	G-X-G motif; other site
272568006484	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568006485	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568006486	active site
272568006487	phosphorylation site [posttranslational modification]
272568006488	intermolecular recognition site; other site
272568006489	dimerization interface [polypeptide binding]; other site
272568006490	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568006491	DNA binding site [nucleotide binding]
272568006492	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
272568006493	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568006494	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568006495	Outer membrane efflux protein; Region: OEP; pfam02321
272568006496	Outer membrane efflux protein; Region: OEP; pfam02321
272568006497	GTP-binding protein LepA; Provisional; Region: PRK05433
272568006498	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
272568006499	G1 box; other site
272568006500	putative GEF interaction site [polypeptide binding]; other site
272568006501	GTP/Mg2+ binding site [chemical binding]; other site
272568006502	Switch I region; other site
272568006503	G2 box; other site
272568006504	G3 box; other site
272568006505	Switch II region; other site
272568006506	G4 box; other site
272568006507	G5 box; other site
272568006508	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
272568006509	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
272568006510	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
272568006511	Tellurite resistance protein TerB; Region: TerB; cl17311
272568006512	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
272568006513	intracellular protease, PfpI family; Region: PfpI; TIGR01382
272568006514	proposed catalytic triad [active]
272568006515	conserved cys residue [active]
272568006516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568006517	D-galactonate transporter; Region: 2A0114; TIGR00893
272568006518	putative substrate translocation pore; other site
272568006519	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
272568006520	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
272568006521	NAD(P) binding site [chemical binding]; other site
272568006522	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
272568006523	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
272568006524	NAD(P) binding site [chemical binding]; other site
272568006525	catalytic residues [active]
272568006526	choline dehydrogenase; Validated; Region: PRK02106
272568006527	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
272568006528	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
272568006529	Coenzyme A transferase; Region: CoA_trans; smart00882
272568006530	Coenzyme A transferase; Region: CoA_trans; cl17247
272568006531	Transposase, Mutator family; Region: Transposase_mut; pfam00872
272568006532	MULE transposase domain; Region: MULE; pfam10551
272568006533	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568006534	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568006535	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
272568006536	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
272568006537	NADP binding site [chemical binding]; other site
272568006538	dimer interface [polypeptide binding]; other site
272568006539	Predicted transcriptional regulator [Transcription]; Region: COG2932
272568006540	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
272568006541	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
272568006542	HflX GTPase family; Region: HflX; cd01878
272568006543	G1 box; other site
272568006544	GTP/Mg2+ binding site [chemical binding]; other site
272568006545	Switch I region; other site
272568006546	G2 box; other site
272568006547	G3 box; other site
272568006548	Switch II region; other site
272568006549	G4 box; other site
272568006550	G5 box; other site
272568006551	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568006552	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568006553	metal binding site [ion binding]; metal-binding site
272568006554	active site
272568006555	I-site; other site
272568006556	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
272568006557	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
272568006558	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
272568006559	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
272568006560	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
272568006561	active site
272568006562	SAM binding site [chemical binding]; other site
272568006563	homodimer interface [polypeptide binding]; other site
272568006564	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
272568006565	Walker A motif; other site
272568006566	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
272568006567	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
272568006568	GTP binding site; other site
272568006569	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
272568006570	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
272568006571	DNA binding site [nucleotide binding]
272568006572	heterodimer interface [polypeptide binding]; other site
272568006573	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
272568006574	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
272568006575	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
272568006576	active site
272568006577	DNA binding site [nucleotide binding]
272568006578	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
272568006579	DNA binding site [nucleotide binding]
272568006580	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
272568006581	nucleotide binding site [chemical binding]; other site
272568006582	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
272568006583	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
272568006584	putative DNA binding site [nucleotide binding]; other site
272568006585	putative homodimer interface [polypeptide binding]; other site
272568006586	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
272568006587	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
272568006588	dimer interface [polypeptide binding]; other site
272568006589	PYR/PP interface [polypeptide binding]; other site
272568006590	TPP binding site [chemical binding]; other site
272568006591	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
272568006592	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
272568006593	TPP-binding site [chemical binding]; other site
272568006594	dimer interface [polypeptide binding]; other site
272568006595	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
272568006596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006597	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
272568006598	putative dimerization interface [polypeptide binding]; other site
272568006599	putative substrate binding pocket [chemical binding]; other site
272568006600	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
272568006601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
272568006602	Uncharacterized conserved protein [Function unknown]; Region: COG2308
272568006603	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
272568006604	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
272568006605	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
272568006606	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
272568006607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
272568006608	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
272568006609	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
272568006610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
272568006611	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
272568006612	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
272568006613	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
272568006614	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
272568006615	pantoate--beta-alanine ligase; Region: panC; TIGR00018
272568006616	Pantoate-beta-alanine ligase; Region: PanC; cd00560
272568006617	active site
272568006618	ATP-binding site [chemical binding]; other site
272568006619	pantoate-binding site; other site
272568006620	HXXH motif; other site
272568006621	Uncharacterized conserved protein [Function unknown]; Region: COG2835
272568006622	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
272568006623	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
272568006624	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
272568006625	Predicted transcriptional regulators [Transcription]; Region: COG1733
272568006626	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
272568006627	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
272568006628	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
272568006629	putative NAD(P) binding site [chemical binding]; other site
272568006630	dimer interface [polypeptide binding]; other site
272568006631	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568006632	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006633	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
272568006634	dimerization interface [polypeptide binding]; other site
272568006635	hypothetical protein; Provisional; Region: PRK05463
272568006636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568006637	D-galactonate transporter; Region: 2A0114; TIGR00893
272568006638	putative substrate translocation pore; other site
272568006639	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568006640	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568006641	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568006642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568006643	metabolite-proton symporter; Region: 2A0106; TIGR00883
272568006644	putative substrate translocation pore; other site
272568006645	hypothetical protein; Validated; Region: PRK06201
272568006646	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
272568006647	transcriptional regulator, ArgP family; Region: argP; TIGR03298
272568006648	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006649	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
272568006650	dimerization interface [polypeptide binding]; other site
272568006651	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
272568006652	Amidase; Region: Amidase; cl11426
272568006653	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
272568006654	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
272568006655	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
272568006656	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
272568006657	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
272568006658	MarR family; Region: MarR_2; cl17246
272568006659	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
272568006660	lipoyl-biotinyl attachment site [posttranslational modification]; other site
272568006661	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
272568006662	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
272568006663	ATP-grasp domain; Region: ATP-grasp_4; cl17255
272568006664	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
272568006665	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
272568006666	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
272568006667	carboxyltransferase (CT) interaction site; other site
272568006668	biotinylation site [posttranslational modification]; other site
272568006669	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
272568006670	putative active site [active]
272568006671	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
272568006672	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
272568006673	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
272568006674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568006675	D-galactonate transporter; Region: 2A0114; TIGR00893
272568006676	putative substrate translocation pore; other site
272568006677	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568006678	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568006679	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568006680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006681	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
272568006682	putative dimerization interface [polypeptide binding]; other site
272568006683	allantoate amidohydrolase; Reviewed; Region: PRK12890
272568006684	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
272568006685	active site
272568006686	metal binding site [ion binding]; metal-binding site
272568006687	dimer interface [polypeptide binding]; other site
272568006688	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
272568006689	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
272568006690	putative active site [active]
272568006691	putative metal binding site [ion binding]; other site
272568006692	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
272568006693	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
272568006694	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
272568006695	ligand binding site [chemical binding]; other site
272568006696	NAD binding site [chemical binding]; other site
272568006697	dimerization interface [polypeptide binding]; other site
272568006698	catalytic site [active]
272568006699	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
272568006700	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568006701	putative metal binding site [ion binding]; other site
272568006702	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
272568006703	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
272568006704	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
272568006705	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
272568006706	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
272568006707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568006708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006709	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
272568006710	putative effector binding pocket; other site
272568006711	dimerization interface [polypeptide binding]; other site
272568006712	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
272568006713	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006714	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
272568006715	dimerization interface [polypeptide binding]; other site
272568006716	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
272568006717	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
272568006718	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
272568006719	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568006720	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006721	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
272568006722	dimerization interface [polypeptide binding]; other site
272568006723	short chain dehydrogenase; Provisional; Region: PRK06500
272568006724	classical (c) SDRs; Region: SDR_c; cd05233
272568006725	NAD(P) binding site [chemical binding]; other site
272568006726	active site
272568006727	Winged helix-turn helix; Region: HTH_29; pfam13551
272568006728	Integrase core domain; Region: rve; pfam00665
272568006729	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
272568006730	Integrase core domain; Region: rve_3; pfam13683
272568006731	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
272568006732	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
272568006733	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
272568006734	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
272568006735	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
272568006736	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
272568006737	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568006738	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568006739	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
272568006740	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568006741	NAD(P) binding site [chemical binding]; other site
272568006742	active site
272568006743	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
272568006744	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
272568006745	FMN binding site [chemical binding]; other site
272568006746	active site
272568006747	substrate binding site [chemical binding]; other site
272568006748	catalytic residue [active]
272568006749	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
272568006750	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568006751	active site
272568006752	phosphorylation site [posttranslational modification]
272568006753	intermolecular recognition site; other site
272568006754	dimerization interface [polypeptide binding]; other site
272568006755	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
272568006756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568006757	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
272568006758	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568006759	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568006760	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568006761	Pirin-related protein [General function prediction only]; Region: COG1741
272568006762	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
272568006763	TPP-binding site [chemical binding]; other site
272568006764	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
272568006765	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
272568006766	PYR/PP interface [polypeptide binding]; other site
272568006767	dimer interface [polypeptide binding]; other site
272568006768	TPP binding site [chemical binding]; other site
272568006769	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
272568006770	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568006771	Flagellin N-methylase; Region: FliB; cl00497
272568006772	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
272568006773	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
272568006774	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
272568006775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568006776	dimer interface [polypeptide binding]; other site
272568006777	conserved gate region; other site
272568006778	putative PBP binding loops; other site
272568006779	ABC-ATPase subunit interface; other site
272568006780	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
272568006781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568006782	dimer interface [polypeptide binding]; other site
272568006783	conserved gate region; other site
272568006784	putative PBP binding loops; other site
272568006785	ABC-ATPase subunit interface; other site
272568006786	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
272568006787	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
272568006788	Walker A/P-loop; other site
272568006789	ATP binding site [chemical binding]; other site
272568006790	Q-loop/lid; other site
272568006791	ABC transporter signature motif; other site
272568006792	Walker B; other site
272568006793	D-loop; other site
272568006794	H-loop/switch region; other site
272568006795	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
272568006796	Walker A/P-loop; other site
272568006797	ATP binding site [chemical binding]; other site
272568006798	Q-loop/lid; other site
272568006799	ABC transporter signature motif; other site
272568006800	Walker B; other site
272568006801	D-loop; other site
272568006802	H-loop/switch region; other site
272568006803	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
272568006804	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
272568006805	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
272568006806	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
272568006807	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
272568006808	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
272568006809	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568006810	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568006811	Response regulator receiver domain; Region: Response_reg; pfam00072
272568006812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568006813	active site
272568006814	phosphorylation site [posttranslational modification]
272568006815	intermolecular recognition site; other site
272568006816	dimerization interface [polypeptide binding]; other site
272568006817	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
272568006818	GAF domain; Region: GAF; pfam01590
272568006819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
272568006820	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568006821	dimer interface [polypeptide binding]; other site
272568006822	phosphorylation site [posttranslational modification]
272568006823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568006824	ATP binding site [chemical binding]; other site
272568006825	Mg2+ binding site [ion binding]; other site
272568006826	G-X-G motif; other site
272568006827	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
272568006828	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
272568006829	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
272568006830	NAD(P) binding site [chemical binding]; other site
272568006831	active site
272568006832	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
272568006833	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
272568006834	putative NAD(P) binding site [chemical binding]; other site
272568006835	substrate binding site [chemical binding]; other site
272568006836	short chain dehydrogenase; Provisional; Region: PRK06500
272568006837	classical (c) SDRs; Region: SDR_c; cd05233
272568006838	NAD(P) binding site [chemical binding]; other site
272568006839	active site
272568006840	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
272568006841	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
272568006842	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
272568006843	DAK2 domain; Region: Dak2; cl03685
272568006844	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
272568006845	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
272568006846	regulatory protein interface [polypeptide binding]; other site
272568006847	active site
272568006848	regulatory phosphorylation site [posttranslational modification]; other site
272568006849	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
272568006850	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
272568006851	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
272568006852	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
272568006853	glycerol kinase; Provisional; Region: glpK; PRK00047
272568006854	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
272568006855	N- and C-terminal domain interface [polypeptide binding]; other site
272568006856	active site
272568006857	MgATP binding site [chemical binding]; other site
272568006858	catalytic site [active]
272568006859	metal binding site [ion binding]; metal-binding site
272568006860	putative homotetramer interface [polypeptide binding]; other site
272568006861	glycerol binding site [chemical binding]; other site
272568006862	homodimer interface [polypeptide binding]; other site
272568006863	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
272568006864	amphipathic channel; other site
272568006865	Asn-Pro-Ala signature motifs; other site
272568006866	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568006867	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
272568006868	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
272568006869	dimerization interface [polypeptide binding]; other site
272568006870	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
272568006871	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568006872	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
272568006873	Methylamine utilisation protein MauE; Region: MauE; pfam07291
272568006874	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568006875	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
272568006876	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
272568006877	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
272568006878	inhibitor-cofactor binding pocket; inhibition site
272568006879	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568006880	catalytic residue [active]
272568006881	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568006882	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
272568006883	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
272568006884	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568006885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568006886	homodimer interface [polypeptide binding]; other site
272568006887	catalytic residue [active]
272568006888	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
272568006889	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
272568006890	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
272568006891	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
272568006892	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
272568006893	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
272568006894	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
272568006895	TPP-binding site [chemical binding]; other site
272568006896	dimer interface [polypeptide binding]; other site
272568006897	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
272568006898	PYR/PP interface [polypeptide binding]; other site
272568006899	dimer interface [polypeptide binding]; other site
272568006900	TPP binding site [chemical binding]; other site
272568006901	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
272568006902	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
272568006903	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
272568006904	putative active site [active]
272568006905	catalytic residue [active]
272568006906	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
272568006907	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
272568006908	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
272568006909	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
272568006910	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
272568006911	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
272568006912	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
272568006913	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568006914	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
272568006915	active site
272568006916	motif I; other site
272568006917	motif II; other site
272568006918	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
272568006919	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568006920	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
272568006921	active site
272568006922	motif I; other site
272568006923	motif II; other site
272568006924	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
272568006925	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
272568006926	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
272568006927	putative active site [active]
272568006928	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
272568006929	tetramer (dimer of dimers) interface [polypeptide binding]; other site
272568006930	active site
272568006931	dimer interface [polypeptide binding]; other site
272568006932	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
272568006933	AAA domain; Region: AAA_33; pfam13671
272568006934	ATP-binding site [chemical binding]; other site
272568006935	Gluconate-6-phosphate binding site [chemical binding]; other site
272568006936	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
272568006937	Homeodomain-like domain; Region: HTH_23; pfam13384
272568006938	Homeodomain-like domain; Region: HTH_32; pfam13565
272568006939	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568006940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568006941	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568006942	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568006943	metal binding site [ion binding]; metal-binding site
272568006944	active site
272568006945	I-site; other site
272568006946	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568006947	Winged helix-turn helix; Region: HTH_29; pfam13551
272568006948	Winged helix-turn helix; Region: HTH_33; pfam13592
272568006949	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568006950	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568006951	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
272568006952	catalytic motif [active]
272568006953	Catalytic residue [active]
272568006954	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
272568006955	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
272568006956	oligomeric interface; other site
272568006957	putative active site [active]
272568006958	homodimer interface [polypeptide binding]; other site
272568006959	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
272568006960	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
272568006961	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
272568006962	phosphate binding site [ion binding]; other site
272568006963	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
272568006964	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
272568006965	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
272568006966	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
272568006967	NAD(P) binding site [chemical binding]; other site
272568006968	catalytic residues [active]
272568006969	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
272568006970	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568006971	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568006972	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568006973	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
272568006974	SPFH domain / Band 7 family; Region: Band_7; pfam01145
272568006975	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
272568006976	Transcriptional regulators [Transcription]; Region: PurR; COG1609
272568006977	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
272568006978	DNA binding site [nucleotide binding]
272568006979	domain linker motif; other site
272568006980	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
272568006981	putative ligand binding site [chemical binding]; other site
272568006982	putative dimerization interface [polypeptide binding]; other site
272568006983	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
272568006984	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
272568006985	substrate binding site [chemical binding]; other site
272568006986	oxyanion hole (OAH) forming residues; other site
272568006987	trimer interface [polypeptide binding]; other site
272568006988	choline dehydrogenase; Validated; Region: PRK02106
272568006989	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568006990	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
272568006991	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
272568006992	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
272568006993	ligand binding site [chemical binding]; other site
272568006994	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568006995	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
272568006996	active site
272568006997	metal binding site [ion binding]; metal-binding site
272568006998	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
272568006999	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
272568007000	Trp docking motif [polypeptide binding]; other site
272568007001	putative active site [active]
272568007002	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
272568007003	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
272568007004	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
272568007005	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
272568007006	Soluble P-type ATPase [General function prediction only]; Region: COG4087
272568007007	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
272568007008	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568007009	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568007010	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
272568007011	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
272568007012	putative active site [active]
272568007013	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568007014	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
272568007015	active site
272568007016	metal binding site [ion binding]; metal-binding site
272568007017	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568007018	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568007019	putative substrate translocation pore; other site
272568007020	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007021	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007022	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568007024	D-galactonate transporter; Region: 2A0114; TIGR00893
272568007025	putative substrate translocation pore; other site
272568007026	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568007027	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568007028	non-specific DNA binding site [nucleotide binding]; other site
272568007029	salt bridge; other site
272568007030	sequence-specific DNA binding site [nucleotide binding]; other site
272568007031	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
272568007032	Fatty acid desaturase; Region: FA_desaturase; pfam00487
272568007033	putative di-iron ligands [ion binding]; other site
272568007034	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
272568007035	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
272568007036	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
272568007037	active site
272568007038	FMN binding site [chemical binding]; other site
272568007039	substrate binding site [chemical binding]; other site
272568007040	homotetramer interface [polypeptide binding]; other site
272568007041	catalytic residue [active]
272568007042	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
272568007043	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
272568007044	ligand binding site [chemical binding]; other site
272568007045	homodimer interface [polypeptide binding]; other site
272568007046	NAD(P) binding site [chemical binding]; other site
272568007047	trimer interface B [polypeptide binding]; other site
272568007048	trimer interface A [polypeptide binding]; other site
272568007049	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
272568007050	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
272568007051	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
272568007052	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
272568007053	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
272568007054	NAD(P) binding site [chemical binding]; other site
272568007055	catalytic residues [active]
272568007056	citrate-proton symporter; Provisional; Region: PRK15075
272568007057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568007058	putative substrate translocation pore; other site
272568007059	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
272568007060	Isochorismatase family; Region: Isochorismatase; pfam00857
272568007061	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
272568007062	catalytic triad [active]
272568007063	conserved cis-peptide bond; other site
272568007064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568007065	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
272568007066	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
272568007067	DNA binding site [nucleotide binding]
272568007068	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
272568007069	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
272568007070	putative ligand binding site [chemical binding]; other site
272568007071	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
272568007072	short chain dehydrogenase; Provisional; Region: PRK06198
272568007073	classical (c) SDRs; Region: SDR_c; cd05233
272568007074	NAD(P) binding site [chemical binding]; other site
272568007075	active site
272568007076	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
272568007077	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
272568007078	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
272568007079	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
272568007080	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
272568007081	putative ligand binding site [chemical binding]; other site
272568007082	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
272568007083	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568007084	Walker A/P-loop; other site
272568007085	ATP binding site [chemical binding]; other site
272568007086	Q-loop/lid; other site
272568007087	ABC transporter signature motif; other site
272568007088	Walker B; other site
272568007089	D-loop; other site
272568007090	H-loop/switch region; other site
272568007091	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568007092	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568007093	TM-ABC transporter signature motif; other site
272568007094	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
272568007095	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
272568007096	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
272568007097	putative active site [active]
272568007098	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
272568007099	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
272568007100	substrate binding site [chemical binding]; other site
272568007101	ATP binding site [chemical binding]; other site
272568007102	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
272568007103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
272568007104	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
272568007105	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
272568007106	dimer interface [polypeptide binding]; other site
272568007107	PYR/PP interface [polypeptide binding]; other site
272568007108	TPP binding site [chemical binding]; other site
272568007109	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
272568007110	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
272568007111	KduI/IolB family; Region: KduI; cl01508
272568007112	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
272568007113	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
272568007114	tetrameric interface [polypeptide binding]; other site
272568007115	NAD binding site [chemical binding]; other site
272568007116	catalytic residues [active]
272568007117	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
272568007118	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
272568007119	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
272568007120	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
272568007121	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568007122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568007123	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568007124	Winged helix-turn helix; Region: HTH_29; pfam13551
272568007125	Integrase core domain; Region: rve; pfam00665
272568007126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
272568007127	Integrase core domain; Region: rve_3; pfam13683
272568007128	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
272568007129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568007130	non-specific DNA binding site [nucleotide binding]; other site
272568007131	salt bridge; other site
272568007132	sequence-specific DNA binding site [nucleotide binding]; other site
272568007133	Winged helix-turn helix; Region: HTH_29; pfam13551
272568007134	Helix-turn-helix domain; Region: HTH_28; pfam13518
272568007135	Integrase core domain; Region: rve; pfam00665
272568007136	Integrase core domain; Region: rve_3; pfam13683
272568007137	Transposase; Region: HTH_Tnp_1; pfam01527
272568007138	putative transposase OrfB; Reviewed; Region: PHA02517
272568007139	HTH-like domain; Region: HTH_21; pfam13276
272568007140	Integrase core domain; Region: rve; pfam00665
272568007141	Integrase core domain; Region: rve_3; pfam13683
272568007142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
272568007143	Transposase; Region: HTH_Tnp_1; cl17663
272568007144	HTH-like domain; Region: HTH_21; pfam13276
272568007145	Integrase core domain; Region: rve; pfam00665
272568007146	Transposase, Mutator family; Region: Transposase_mut; pfam00872
272568007147	MULE transposase domain; Region: MULE; pfam10551
272568007148	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
272568007149	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
272568007150	active site
272568007151	DNA binding site [nucleotide binding]
272568007152	Int/Topo IB signature motif; other site
272568007153	Phage Tail Collar Domain; Region: Collar; pfam07484
272568007154	crystallin beta/gamma motif-containing protein; Region: PHA00657
272568007155	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
272568007156	Coenzyme A binding pocket [chemical binding]; other site
272568007157	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
272568007158	oligomerisation interface [polypeptide binding]; other site
272568007159	mobile loop; other site
272568007160	roof hairpin; other site
272568007161	Terminase-like family; Region: Terminase_6; pfam03237
272568007162	Phage terminase large subunit; Region: Terminase_3; cl12054
272568007163	Terminase small subunit; Region: Terminase_2; pfam03592
272568007164	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
272568007165	active site
272568007166	metal binding site [ion binding]; metal-binding site
272568007167	interdomain interaction site; other site
272568007168	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
272568007169	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
272568007170	ATP binding site [chemical binding]; other site
272568007171	putative Mg++ binding site [ion binding]; other site
272568007172	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568007173	nucleotide binding region [chemical binding]; other site
272568007174	ATP-binding site [chemical binding]; other site
272568007175	Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338
272568007176	Predicted transcriptional regulator [Transcription]; Region: COG2944
272568007177	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568007178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568007179	non-specific DNA binding site [nucleotide binding]; other site
272568007180	salt bridge; other site
272568007181	sequence-specific DNA binding site [nucleotide binding]; other site
272568007182	hypothetical protein; Provisional; Region: PRK09946
272568007183	exonuclease VIII; Reviewed; Region: PRK09709
272568007184	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
272568007185	Walker A motif; other site
272568007186	ATP binding site [chemical binding]; other site
272568007187	Walker B motif; other site
272568007188	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
272568007189	integrase; Provisional; Region: int; PHA02601
272568007190	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
272568007191	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
272568007192	active site
272568007193	catalytic residues [active]
272568007194	Int/Topo IB signature motif; other site
272568007195	DNA binding site [nucleotide binding]
272568007196	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
272568007197	DHH family; Region: DHH; pfam01368
272568007198	DHHA1 domain; Region: DHHA1; pfam02272
272568007199	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
272568007200	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
272568007201	putative active site [active]
272568007202	homoserine dehydrogenase; Provisional; Region: PRK06349
272568007203	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
272568007204	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
272568007205	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
272568007206	aminotransferase; Validated; Region: PRK09148
272568007207	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568007208	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568007209	homodimer interface [polypeptide binding]; other site
272568007210	catalytic residue [active]
272568007211	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
272568007212	Clp protease; Region: CLP_protease; pfam00574
272568007213	oligomer interface [polypeptide binding]; other site
272568007214	active site residues [active]
272568007215	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
272568007216	dinuclear metal binding motif [ion binding]; other site
272568007217	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
272568007218	putative transposase OrfB; Reviewed; Region: PHA02517
272568007219	HTH-like domain; Region: HTH_21; pfam13276
272568007220	Integrase core domain; Region: rve; pfam00665
272568007221	Integrase core domain; Region: rve_3; cl15866
272568007222	YfdX protein; Region: YfdX; pfam10938
272568007223	hypothetical protein; Provisional; Region: PRK10316
272568007224	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
272568007225	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
272568007226	Na binding site [ion binding]; other site
272568007227	putative substrate binding site [chemical binding]; other site
272568007228	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568007229	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568007230	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
272568007231	dimerization interface [polypeptide binding]; other site
272568007232	cytosine deaminase; Provisional; Region: PRK05985
272568007233	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
272568007234	active site
272568007235	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568007236	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
272568007237	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
272568007238	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
272568007239	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
272568007240	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
272568007241	Sulfate transporter family; Region: Sulfate_transp; pfam00916
272568007242	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
272568007243	FOG: CBS domain [General function prediction only]; Region: COG0517
272568007244	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
272568007245	BON domain; Region: BON; pfam04972
272568007246	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
272568007247	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
272568007248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568007249	PAS fold; Region: PAS_3; pfam08447
272568007250	putative active site [active]
272568007251	heme pocket [chemical binding]; other site
272568007252	PAS fold; Region: PAS_3; pfam08447
272568007253	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568007254	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568007255	metal binding site [ion binding]; metal-binding site
272568007256	active site
272568007257	I-site; other site
272568007258	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
272568007259	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
272568007260	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
272568007261	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
272568007262	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
272568007263	Cupin domain; Region: Cupin_2; pfam07883
272568007264	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568007265	putative DNA binding site [nucleotide binding]; other site
272568007266	putative Zn2+ binding site [ion binding]; other site
272568007267	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
272568007268	ArsC family; Region: ArsC; pfam03960
272568007269	catalytic residues [active]
272568007270	arsenical pump membrane protein; Provisional; Region: PRK15445
272568007271	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
272568007272	transmembrane helices; other site
272568007273	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
272568007274	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
272568007275	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
272568007276	motif II; other site
272568007277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
272568007278	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
272568007279	hypothetical protein; Provisional; Region: PRK09256
272568007280	Predicted transcriptional regulator [Transcription]; Region: COG2932
272568007281	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
272568007282	Catalytic site [active]
272568007283	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
272568007284	hypothetical protein; Validated; Region: PRK07078
272568007285	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
272568007286	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568007287	PAS domain; Region: PAS_9; pfam13426
272568007288	putative active site [active]
272568007289	heme pocket [chemical binding]; other site
272568007290	PAS fold; Region: PAS_7; pfam12860
272568007291	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568007292	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568007293	metal binding site [ion binding]; metal-binding site
272568007294	active site
272568007295	I-site; other site
272568007296	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568007297	Terminase small subunit; Region: Terminase_2; pfam03592
272568007298	Phage terminase large subunit; Region: Terminase_3; cl12054
272568007299	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
272568007300	oligomerisation interface [polypeptide binding]; other site
272568007301	mobile loop; other site
272568007302	roof hairpin; other site
272568007303	hypothetical protein; Provisional; Region: PRK10316
272568007304	Phage Tail Collar Domain; Region: Collar; pfam07484
272568007305	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
272568007306	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
272568007307	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
272568007308	heme binding site [chemical binding]; other site
272568007309	ferroxidase pore; other site
272568007310	ferroxidase diiron center [ion binding]; other site
272568007311	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
272568007312	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
272568007313	ATP binding site [chemical binding]; other site
272568007314	Mg++ binding site [ion binding]; other site
272568007315	motif III; other site
272568007316	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568007317	nucleotide binding region [chemical binding]; other site
272568007318	ATP-binding site [chemical binding]; other site
272568007319	Protein of unknown function DUF262; Region: DUF262; pfam03235
272568007320	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007321	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007322	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007323	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
272568007324	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
272568007325	putative active site [active]
272568007326	putative metal binding site [ion binding]; other site
272568007327	GAF domain; Region: GAF; pfam01590
272568007328	GAF domain; Region: GAF_2; pfam13185
272568007329	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
272568007330	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568007331	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568007332	metal binding site [ion binding]; metal-binding site
272568007333	active site
272568007334	I-site; other site
272568007335	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568007336	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007337	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007338	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007339	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
272568007340	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
272568007341	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
272568007342	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
272568007343	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568007344	N-terminal plug; other site
272568007345	ligand-binding site [chemical binding]; other site
272568007346	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568007347	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
272568007348	N-terminal plug; other site
272568007349	ligand-binding site [chemical binding]; other site
272568007350	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
272568007351	Winged helix-turn helix; Region: HTH_29; pfam13551
272568007352	Winged helix-turn helix; Region: HTH_33; pfam13592
272568007353	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568007354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568007355	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
272568007356	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
272568007357	FtsX-like permease family; Region: FtsX; pfam02687
272568007358	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
272568007359	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
272568007360	FtsX-like permease family; Region: FtsX; pfam02687
272568007361	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
272568007362	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
272568007363	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
272568007364	FtsX-like permease family; Region: FtsX; pfam02687
272568007365	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
272568007366	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
272568007367	Walker A/P-loop; other site
272568007368	ATP binding site [chemical binding]; other site
272568007369	Q-loop/lid; other site
272568007370	ABC transporter signature motif; other site
272568007371	Walker B; other site
272568007372	D-loop; other site
272568007373	H-loop/switch region; other site
272568007374	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
272568007375	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568007376	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568007377	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
272568007378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568007379	active site
272568007380	phosphorylation site [posttranslational modification]
272568007381	intermolecular recognition site; other site
272568007382	dimerization interface [polypeptide binding]; other site
272568007383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568007384	Walker A motif; other site
272568007385	ATP binding site [chemical binding]; other site
272568007386	Walker B motif; other site
272568007387	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
272568007388	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
272568007389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568007390	ATP binding site [chemical binding]; other site
272568007391	Mg2+ binding site [ion binding]; other site
272568007392	G-X-G motif; other site
272568007393	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
272568007394	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
272568007395	Walker A/P-loop; other site
272568007396	ATP binding site [chemical binding]; other site
272568007397	Q-loop/lid; other site
272568007398	ABC transporter signature motif; other site
272568007399	Walker B; other site
272568007400	D-loop; other site
272568007401	H-loop/switch region; other site
272568007402	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
272568007403	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568007404	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568007405	TM-ABC transporter signature motif; other site
272568007406	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568007407	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
272568007408	TM-ABC transporter signature motif; other site
272568007409	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
272568007410	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
272568007411	ligand binding site [chemical binding]; other site
272568007412	Uncharacterized conserved protein [Function unknown]; Region: COG1359
272568007413	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
272568007414	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
272568007415	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
272568007416	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
272568007417	dimer interface [polypeptide binding]; other site
272568007418	metal binding site [ion binding]; metal-binding site
272568007419	substrate binding site [chemical binding]; other site
272568007420	short chain dehydrogenase; Provisional; Region: PRK06125
272568007421	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568007422	NAD(P) binding site [chemical binding]; other site
272568007423	active site
272568007424	Transcriptional regulators [Transcription]; Region: PurR; COG1609
272568007425	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
272568007426	DNA binding site [nucleotide binding]
272568007427	domain linker motif; other site
272568007428	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
272568007429	putative dimerization interface [polypeptide binding]; other site
272568007430	putative ligand binding site [chemical binding]; other site
272568007431	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
272568007432	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
272568007433	substrate binding [chemical binding]; other site
272568007434	active site
272568007435	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
272568007436	Abortive infection C-terminus; Region: Abi_C; pfam14355
272568007437	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
272568007438	putative active site [active]
272568007439	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
272568007440	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
272568007441	DNA-binding site [nucleotide binding]; DNA binding site
272568007442	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568007443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568007444	homodimer interface [polypeptide binding]; other site
272568007445	catalytic residue [active]
272568007446	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
272568007447	Predicted amidohydrolase [General function prediction only]; Region: COG0388
272568007448	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
272568007449	putative active site [active]
272568007450	catalytic triad [active]
272568007451	putative dimer interface [polypeptide binding]; other site
272568007452	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
272568007453	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568007454	FeS/SAM binding site; other site
272568007455	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
272568007456	Coenzyme A binding pocket [chemical binding]; other site
272568007457	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
272568007458	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
272568007459	dimerization interface [polypeptide binding]; other site
272568007460	putative ATP binding site [chemical binding]; other site
272568007461	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
272568007462	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
272568007463	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
272568007464	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
272568007465	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568007466	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
272568007467	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
272568007468	acyl-activating enzyme (AAE) consensus motif; other site
272568007469	AMP binding site [chemical binding]; other site
272568007470	active site
272568007471	CoA binding site [chemical binding]; other site
272568007472	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568007473	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
272568007474	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
272568007475	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
272568007476	dimerization interface [polypeptide binding]; other site
272568007477	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
272568007478	putative active cleft [active]
272568007479	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
272568007480	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
272568007481	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
272568007482	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
272568007483	putative active site [active]
272568007484	catalytic site [active]
272568007485	putative metal binding site [ion binding]; other site
272568007486	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568007487	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568007488	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
272568007489	MarR family; Region: MarR_2; cl17246
272568007490	Fusaric acid resistance protein family; Region: FUSC; pfam04632
272568007491	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
272568007492	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
272568007493	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568007494	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568007495	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568007496	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
272568007497	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
272568007498	Cl- selectivity filter; other site
272568007499	Cl- binding residues [ion binding]; other site
272568007500	pore gating glutamate residue; other site
272568007501	dimer interface [polypeptide binding]; other site
272568007502	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
272568007503	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
272568007504	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568007505	Walker A/P-loop; other site
272568007506	ATP binding site [chemical binding]; other site
272568007507	Q-loop/lid; other site
272568007508	ABC transporter signature motif; other site
272568007509	Walker B; other site
272568007510	D-loop; other site
272568007511	H-loop/switch region; other site
272568007512	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568007513	Walker A/P-loop; other site
272568007514	ATP binding site [chemical binding]; other site
272568007515	Q-loop/lid; other site
272568007516	ABC transporter signature motif; other site
272568007517	Walker B; other site
272568007518	D-loop; other site
272568007519	H-loop/switch region; other site
272568007520	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
272568007521	Ligand Binding Site [chemical binding]; other site
272568007522	CrcB-like protein; Region: CRCB; cl09114
272568007523	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
272568007524	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
272568007525	Predicted transcriptional regulators [Transcription]; Region: COG1733
272568007526	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
272568007527	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
272568007528	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
272568007529	DNA binding site [nucleotide binding]
272568007530	substrate interaction site [chemical binding]; other site
272568007531	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
272568007532	Transposase; Region: HTH_Tnp_1; pfam01527
272568007533	putative transposase OrfB; Reviewed; Region: PHA02517
272568007534	HTH-like domain; Region: HTH_21; pfam13276
272568007535	Integrase core domain; Region: rve; pfam00665
272568007536	Integrase core domain; Region: rve_3; pfam13683
272568007537	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
272568007538	ATP binding site [chemical binding]; other site
272568007539	Mg2+ binding site [ion binding]; other site
272568007540	G-X-G motif; other site
272568007541	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
272568007542	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568007543	ATP binding site [chemical binding]; other site
272568007544	G-X-G motif; other site
272568007545	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
272568007546	additional DNA contacts [nucleotide binding]; other site
272568007547	mismatch recognition site; other site
272568007548	active site
272568007549	zinc binding site [ion binding]; other site
272568007550	DNA intercalation site [nucleotide binding]; other site
272568007551	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568007552	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007553	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568007554	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007555	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007556	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007557	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
272568007558	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568007559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568007560	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
272568007561	putative effector binding pocket; other site
272568007562	putative dimerization interface [polypeptide binding]; other site
272568007563	short chain dehydrogenase; Provisional; Region: PRK12744
272568007564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568007565	NAD(P) binding site [chemical binding]; other site
272568007566	active site
272568007567	putative proline-specific permease; Provisional; Region: proY; PRK10580
272568007568	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
272568007569	active site
272568007570	oligomerization interface [polypeptide binding]; other site
272568007571	metal binding site [ion binding]; metal-binding site
272568007572	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
272568007573	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
272568007574	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
272568007575	Mechanosensitive ion channel; Region: MS_channel; pfam00924
272568007576	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
272568007577	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568007578	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568007579	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
272568007580	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568007581	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
272568007582	YcfA-like protein; Region: YcfA; pfam07927
272568007583	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
272568007584	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
272568007585	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
272568007586	Integrase core domain; Region: rve; pfam00665
272568007587	transposase/IS protein; Provisional; Region: PRK09183
272568007588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568007589	Walker A motif; other site
272568007590	ATP binding site [chemical binding]; other site
272568007591	Walker B motif; other site
272568007592	arginine finger; other site
272568007593	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
272568007594	DNA-binding site [nucleotide binding]; DNA binding site
272568007595	RNA-binding motif; other site
272568007596	PAS fold; Region: PAS; pfam00989
272568007597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568007598	putative active site [active]
272568007599	heme pocket [chemical binding]; other site
272568007600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
272568007601	PAS domain; Region: PAS_9; pfam13426
272568007602	putative active site [active]
272568007603	heme pocket [chemical binding]; other site
272568007604	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
272568007605	GAF domain; Region: GAF; cl17456
272568007606	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568007607	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568007608	metal binding site [ion binding]; metal-binding site
272568007609	active site
272568007610	I-site; other site
272568007611	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
272568007612	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
272568007613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568007614	dimer interface [polypeptide binding]; other site
272568007615	conserved gate region; other site
272568007616	putative PBP binding loops; other site
272568007617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
272568007618	ABC-ATPase subunit interface; other site
272568007619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568007620	dimer interface [polypeptide binding]; other site
272568007621	conserved gate region; other site
272568007622	putative PBP binding loops; other site
272568007623	ABC-ATPase subunit interface; other site
272568007624	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
272568007625	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
272568007626	Walker A/P-loop; other site
272568007627	ATP binding site [chemical binding]; other site
272568007628	Q-loop/lid; other site
272568007629	ABC transporter signature motif; other site
272568007630	Walker B; other site
272568007631	D-loop; other site
272568007632	H-loop/switch region; other site
272568007633	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
272568007634	PhoU domain; Region: PhoU; pfam01895
272568007635	PhoU domain; Region: PhoU; pfam01895
272568007636	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
272568007637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568007638	active site
272568007639	phosphorylation site [posttranslational modification]
272568007640	intermolecular recognition site; other site
272568007641	dimerization interface [polypeptide binding]; other site
272568007642	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568007643	DNA binding site [nucleotide binding]
272568007644	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
272568007645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568007646	dimer interface [polypeptide binding]; other site
272568007647	phosphorylation site [posttranslational modification]
272568007648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568007649	ATP binding site [chemical binding]; other site
272568007650	Mg2+ binding site [ion binding]; other site
272568007651	G-X-G motif; other site
272568007652	PBP superfamily domain; Region: PBP_like_2; cl17296
272568007653	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
272568007654	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
272568007655	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
272568007656	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
272568007657	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568007658	sequence-specific DNA binding site [nucleotide binding]; other site
272568007659	salt bridge; other site
272568007660	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
272568007661	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007662	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007663	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007664	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
272568007665	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
272568007666	Walker A/P-loop; other site
272568007667	ATP binding site [chemical binding]; other site
272568007668	Q-loop/lid; other site
272568007669	ABC transporter signature motif; other site
272568007670	Walker B; other site
272568007671	D-loop; other site
272568007672	H-loop/switch region; other site
272568007673	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
272568007674	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
272568007675	substrate binding pocket [chemical binding]; other site
272568007676	membrane-bound complex binding site; other site
272568007677	hinge residues; other site
272568007678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568007679	dimer interface [polypeptide binding]; other site
272568007680	conserved gate region; other site
272568007681	putative PBP binding loops; other site
272568007682	ABC-ATPase subunit interface; other site
272568007683	aldolase II superfamily protein; Provisional; Region: PRK07044
272568007684	intersubunit interface [polypeptide binding]; other site
272568007685	active site
272568007686	Zn2+ binding site [ion binding]; other site
272568007687	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
272568007688	dimerization interface [polypeptide binding]; other site
272568007689	putative DNA binding site [nucleotide binding]; other site
272568007690	putative Zn2+ binding site [ion binding]; other site
272568007691	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
272568007692	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568007693	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
272568007694	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
272568007695	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
272568007696	FOG: CBS domain [General function prediction only]; Region: COG0517
272568007697	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
272568007698	Erythromycin esterase; Region: Erythro_esteras; pfam05139
272568007699	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
272568007700	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568007701	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568007702	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
272568007703	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
272568007704	Walker A/P-loop; other site
272568007705	ATP binding site [chemical binding]; other site
272568007706	Q-loop/lid; other site
272568007707	ABC transporter signature motif; other site
272568007708	Walker B; other site
272568007709	D-loop; other site
272568007710	H-loop/switch region; other site
272568007711	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
272568007712	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
272568007713	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568007714	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568007715	metal binding site [ion binding]; metal-binding site
272568007716	active site
272568007717	I-site; other site
272568007718	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568007719	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007720	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568007721	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007722	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007723	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007724	Predicted acetyltransferase [General function prediction only]; Region: COG2388
272568007725	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
272568007726	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
272568007727	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
272568007728	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
272568007729	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568007730	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568007731	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568007732	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568007733	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568007734	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
272568007735	putative effector binding pocket; other site
272568007736	dimerization interface [polypeptide binding]; other site
272568007737	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
272568007738	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
272568007739	C-terminal domain interface [polypeptide binding]; other site
272568007740	GSH binding site (G-site) [chemical binding]; other site
272568007741	dimer interface [polypeptide binding]; other site
272568007742	Winged helix-turn helix; Region: HTH_29; pfam13551
272568007743	Integrase core domain; Region: rve; pfam00665
272568007744	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
272568007745	Integrase core domain; Region: rve_3; pfam13683
272568007746	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
272568007747	ParA-like protein; Provisional; Region: PHA02518
272568007748	P-loop; other site
272568007749	Magnesium ion binding site [ion binding]; other site
272568007750	Transposase; Region: HTH_Tnp_IS630; pfam01710
272568007751	Homeodomain-like domain; Region: HTH_23; pfam13384
272568007752	Homeodomain-like domain; Region: HTH_32; pfam13565
272568007753	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568007754	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568007755	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
272568007756	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
272568007757	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007758	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007759	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007760	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007761	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007762	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007763	Winged helix-turn helix; Region: HTH_29; pfam13551
272568007764	Winged helix-turn helix; Region: HTH_33; pfam13592
272568007765	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568007766	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568007767	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568007768	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007769	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568007770	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
272568007771	Winged helix-turn helix; Region: HTH_29; pfam13551
272568007772	Winged helix-turn helix; Region: HTH_33; pfam13592
272568007773	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568007774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568007775	Short C-terminal domain; Region: SHOCT; pfam09851
272568007776	Winged helix-turn helix; Region: HTH_29; pfam13551
272568007777	Winged helix-turn helix; Region: HTH_33; pfam13592
272568007778	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568007779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568007780	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568007781	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568007782	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568007783	Integrase core domain; Region: rve; pfam00665
272568007784	Integrase core domain; Region: rve_3; cl15866
272568007785	Winged helix-turn helix; Region: HTH_29; pfam13551
272568007786	Helix-turn-helix domain; Region: HTH_28; pfam13518
272568007787	Integrase core domain; Region: rve; pfam00665
272568007788	Integrase core domain; Region: rve_3; pfam13683
272568007789	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
272568007790	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
272568007791	Integrase core domain; Region: rve; pfam00665
272568007792	Transposase, Mutator family; Region: Transposase_mut; pfam00872
272568007793	MULE transposase domain; Region: MULE; pfam10551
272568007794	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
272568007795	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
272568007796	tetramer interface [polypeptide binding]; other site
272568007797	active site
272568007798	methionine sulfoxide reductase A; Provisional; Region: PRK13014
272568007799	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
272568007800	SelR domain; Region: SelR; pfam01641
272568007801	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
272568007802	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
272568007803	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
272568007804	Moco binding site; other site
272568007805	metal coordination site [ion binding]; other site
272568007806	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
272568007807	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
272568007808	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
272568007809	amidase; Provisional; Region: PRK08137
272568007810	Amidase; Region: Amidase; cl11426
272568007811	Uncharacterized conserved protein [Function unknown]; Region: COG3791
272568007812	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
272568007813	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
272568007814	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
272568007815	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
272568007816	Bacterial SH3 domain; Region: SH3_3; pfam08239
272568007817	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
272568007818	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
272568007819	active site
272568007820	DNA binding site [nucleotide binding]
272568007821	Int/Topo IB signature motif; other site
272568007822	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
272568007823	putative active site pocket [active]
272568007824	dimerization interface [polypeptide binding]; other site
272568007825	putative catalytic residue [active]
272568007826	AAA domain; Region: AAA_21; pfam13304
272568007827	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
272568007828	AAA domain; Region: AAA_14; pfam13173
272568007829	ParB-like nuclease domain; Region: ParB; smart00470
272568007830	Methyltransferase domain; Region: Methyltransf_26; pfam13659
272568007831	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
272568007832	Helicase_C-like; Region: Helicase_C_4; pfam13871
272568007833	Toprim domain; Region: Toprim_3; pfam13362
272568007834	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
272568007835	Uncharacterized conserved protein [Function unknown]; Region: COG5489
272568007836	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568007837	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568007838	non-specific DNA binding site [nucleotide binding]; other site
272568007839	salt bridge; other site
272568007840	sequence-specific DNA binding site [nucleotide binding]; other site
272568007841	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
272568007842	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568007843	non-specific DNA binding site [nucleotide binding]; other site
272568007844	salt bridge; other site
272568007845	sequence-specific DNA binding site [nucleotide binding]; other site
272568007846	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
272568007847	Helix-turn-helix domain; Region: HTH_17; pfam12728
272568007848	Replication initiator protein A; Region: RPA; pfam10134
272568007849	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
272568007850	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
272568007851	P-loop; other site
272568007852	Magnesium ion binding site [ion binding]; other site
272568007853	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
272568007854	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
272568007855	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
272568007856	Protein of unknown function (DUF736); Region: DUF736; pfam05284
272568007857	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
272568007858	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568007859	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568007860	catalytic residue [active]
272568007861	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568007862	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568007863	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568007864	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
272568007865	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
272568007866	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
272568007867	non-specific DNA binding site [nucleotide binding]; other site
272568007868	salt bridge; other site
272568007869	sequence-specific DNA binding site [nucleotide binding]; other site
272568007870	conjugal transfer protein TrbA; Provisional; Region: PRK13890
272568007871	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
272568007872	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
272568007873	NAD(P) binding site [chemical binding]; other site
272568007874	hypothetical protein; Provisional; Region: PRK06834
272568007875	hydroxyglutarate oxidase; Provisional; Region: PRK11728
272568007876	short chain dehydrogenase; Provisional; Region: PRK06180
272568007877	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
272568007878	NADP binding site [chemical binding]; other site
272568007879	active site
272568007880	steroid binding site; other site
272568007881	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568007882	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568007883	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
272568007884	putative effector binding pocket; other site
272568007885	putative dimerization interface [polypeptide binding]; other site
272568007886	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
272568007887	NADP binding site [chemical binding]; other site
272568007888	active site
272568007889	steroid binding site; other site
272568007890	Cupin; Region: Cupin_6; pfam12852
272568007891	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
272568007892	H+ Antiporter protein; Region: 2A0121; TIGR00900
272568007893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568007894	putative substrate translocation pore; other site
272568007895	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
272568007896	Isochorismatase family; Region: Isochorismatase; pfam00857
272568007897	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
272568007898	catalytic triad [active]
272568007899	conserved cis-peptide bond; other site
272568007900	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
272568007901	MarR family; Region: MarR; pfam01047
272568007902	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
272568007903	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
272568007904	Walker A motif; other site
272568007905	ATP binding site [chemical binding]; other site
272568007906	Walker B motif; other site
272568007907	beta-lactamase TEM; Provisional; Region: PRK15442
272568007908	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
272568007909	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
272568007910	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
272568007911	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
272568007912	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
272568007913	Walker A motif; other site
272568007914	ATP binding site [chemical binding]; other site
272568007915	Walker B motif; other site
272568007916	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
272568007917	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
272568007918	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
272568007919	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
272568007920	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568007921	Walker A/P-loop; other site
272568007922	ATP binding site [chemical binding]; other site
272568007923	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
272568007924	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
272568007925	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
272568007926	conjugal transfer protein TrbL; Provisional; Region: PRK13875
272568007927	P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783
272568007928	conjugal transfer protein TrbF; Provisional; Region: PRK13872
272568007929	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
272568007930	VirB7 interaction site; other site
272568007931	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
272568007932	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
272568007933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
272568007934	Homeodomain-like domain; Region: HTH_23; pfam13384
272568007935	Homeodomain-like domain; Region: HTH_32; pfam13565
272568007936	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568007937	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568007938	FAD binding domain; Region: FAD_binding_3; pfam01494
272568007939	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
272568007940	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
272568007941	active site
272568007942	catalytic triad [active]
272568007943	oxyanion hole [active]
272568007944	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
272568007945	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
272568007946	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568007947	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
272568007948	EamA-like transporter family; Region: EamA; cl17759
272568007949	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
272568007950	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
272568007951	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
272568007952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
272568007953	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
272568007954	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
272568007955	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
272568007956	Zinc-finger domain; Region: zf-CHCC; pfam10276
272568007957	DNA polymerase I; Provisional; Region: PRK05755
272568007958	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
272568007959	active site
272568007960	metal binding site 1 [ion binding]; metal-binding site
272568007961	putative 5' ssDNA interaction site; other site
272568007962	metal binding site 3; metal-binding site
272568007963	metal binding site 2 [ion binding]; metal-binding site
272568007964	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
272568007965	putative DNA binding site [nucleotide binding]; other site
272568007966	putative metal binding site [ion binding]; other site
272568007967	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
272568007968	active site
272568007969	catalytic site [active]
272568007970	substrate binding site [chemical binding]; other site
272568007971	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
272568007972	active site
272568007973	DNA binding site [nucleotide binding]
272568007974	catalytic site [active]
272568007975	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
272568007976	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
272568007977	Cu(I) binding site [ion binding]; other site
272568007978	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
272568007979	peptide binding site [polypeptide binding]; other site
272568007980	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
272568007981	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
272568007982	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568007983	dimer interface [polypeptide binding]; other site
272568007984	conserved gate region; other site
272568007985	ABC-ATPase subunit interface; other site
272568007986	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
272568007987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568007988	dimer interface [polypeptide binding]; other site
272568007989	conserved gate region; other site
272568007990	putative PBP binding loops; other site
272568007991	ABC-ATPase subunit interface; other site
272568007992	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
272568007993	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
272568007994	Walker A/P-loop; other site
272568007995	ATP binding site [chemical binding]; other site
272568007996	Q-loop/lid; other site
272568007997	ABC transporter signature motif; other site
272568007998	Walker B; other site
272568007999	D-loop; other site
272568008000	H-loop/switch region; other site
272568008001	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
272568008002	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
272568008003	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
272568008004	Walker A/P-loop; other site
272568008005	ATP binding site [chemical binding]; other site
272568008006	Q-loop/lid; other site
272568008007	ABC transporter signature motif; other site
272568008008	Walker B; other site
272568008009	D-loop; other site
272568008010	H-loop/switch region; other site
272568008011	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
272568008012	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
272568008013	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
272568008014	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
272568008015	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
272568008016	DXD motif; other site
272568008017	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
272568008018	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
272568008019	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568008020	NAD(P) binding site [chemical binding]; other site
272568008021	active site
272568008022	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
272568008023	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
272568008024	NAD binding site [chemical binding]; other site
272568008025	catalytic Zn binding site [ion binding]; other site
272568008026	structural Zn binding site [ion binding]; other site
272568008027	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
272568008028	dinuclear metal binding motif [ion binding]; other site
272568008029	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
272568008030	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
272568008031	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
272568008032	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
272568008033	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
272568008034	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
272568008035	generic binding surface II; other site
272568008036	generic binding surface I; other site
272568008037	BA14K-like protein; Region: BA14K; pfam07886
272568008038	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
272568008039	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
272568008040	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
272568008041	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
272568008042	Catalytic site [active]
272568008043	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
272568008044	MgtC family; Region: MgtC; pfam02308
272568008045	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
272568008046	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
272568008047	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
272568008048	Autotransporter beta-domain; Region: Autotransporter; pfam03797
272568008049	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
272568008050	putative deacylase active site [active]
272568008051	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568008052	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
272568008053	NAD(P) binding site [chemical binding]; other site
272568008054	active site
272568008055	amidophosphoribosyltransferase; Provisional; Region: PRK09123
272568008056	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
272568008057	active site
272568008058	tetramer interface [polypeptide binding]; other site
272568008059	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
272568008060	active site
272568008061	Colicin V production protein; Region: Colicin_V; pfam02674
272568008062	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
272568008063	metal binding site [ion binding]; metal-binding site
272568008064	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
272568008065	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
272568008066	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
272568008067	substrate binding pocket [chemical binding]; other site
272568008068	dimer interface [polypeptide binding]; other site
272568008069	inhibitor binding site; inhibition site
272568008070	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
272568008071	B12 binding site [chemical binding]; other site
272568008072	cobalt ligand [ion binding]; other site
272568008073	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
272568008074	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
272568008075	putative active site [active]
272568008076	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
272568008077	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
272568008078	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568008079	Walker A/P-loop; other site
272568008080	ATP binding site [chemical binding]; other site
272568008081	Q-loop/lid; other site
272568008082	ABC transporter signature motif; other site
272568008083	Walker B; other site
272568008084	D-loop; other site
272568008085	H-loop/switch region; other site
272568008086	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
272568008087	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568008088	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568008089	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568008090	Sel1-like repeats; Region: SEL1; smart00671
272568008091	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568008092	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568008093	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
272568008094	active site
272568008095	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568008096	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
272568008097	putative ADP-binding pocket [chemical binding]; other site
272568008098	hypothetical protein; Provisional; Region: PRK02237
272568008099	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
272568008100	dimer interface [polypeptide binding]; other site
272568008101	substrate binding site [chemical binding]; other site
272568008102	metal binding sites [ion binding]; metal-binding site
272568008103	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
272568008104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568008105	Walker A/P-loop; other site
272568008106	ATP binding site [chemical binding]; other site
272568008107	Q-loop/lid; other site
272568008108	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568008109	ABC transporter; Region: ABC_tran_2; pfam12848
272568008110	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568008111	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
272568008112	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
272568008113	Coenzyme A binding pocket [chemical binding]; other site
272568008114	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
272568008115	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
272568008116	ligand binding site [chemical binding]; other site
272568008117	flexible hinge region; other site
272568008118	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
272568008119	putative switch regulator; other site
272568008120	non-specific DNA interactions [nucleotide binding]; other site
272568008121	DNA binding site [nucleotide binding]
272568008122	sequence specific DNA binding site [nucleotide binding]; other site
272568008123	putative cAMP binding site [chemical binding]; other site
272568008124	hypothetical protein; Validated; Region: PRK00228
272568008125	malonic semialdehyde reductase; Provisional; Region: PRK10538
272568008126	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568008127	NAD(P) binding site [chemical binding]; other site
272568008128	active site
272568008129	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
272568008130	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
272568008131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568008132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568008133	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480
272568008134	putative effector binding pocket; other site
272568008135	putative dimerization interface [polypeptide binding]; other site
272568008136	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568008137	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
272568008138	NAD(P) binding site [chemical binding]; other site
272568008139	active site
272568008140	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
272568008141	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
272568008142	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
272568008143	Predicted membrane protein [Function unknown]; Region: COG2259
272568008144	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
272568008145	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568008146	Walker A motif; other site
272568008147	ATP binding site [chemical binding]; other site
272568008148	Walker B motif; other site
272568008149	arginine finger; other site
272568008150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568008151	Walker A motif; other site
272568008152	ATP binding site [chemical binding]; other site
272568008153	Walker B motif; other site
272568008154	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
272568008155	Uncharacterized conserved protein [Function unknown]; Region: COG2127
272568008156	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
272568008157	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
272568008158	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
272568008159	active site
272568008160	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
272568008161	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
272568008162	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
272568008163	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
272568008164	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
272568008165	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
272568008166	putative NADH binding site [chemical binding]; other site
272568008167	putative active site [active]
272568008168	nudix motif; other site
272568008169	putative metal binding site [ion binding]; other site
272568008170	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
272568008171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568008172	Walker A motif; other site
272568008173	ATP binding site [chemical binding]; other site
272568008174	Walker B motif; other site
272568008175	arginine finger; other site
272568008176	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
272568008177	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
272568008178	hypothetical protein; Validated; Region: PRK00153
272568008179	recombination protein RecR; Reviewed; Region: recR; PRK00076
272568008180	RecR protein; Region: RecR; pfam02132
272568008181	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
272568008182	putative active site [active]
272568008183	putative metal-binding site [ion binding]; other site
272568008184	tetramer interface [polypeptide binding]; other site
272568008185	short chain dehydrogenase; Provisional; Region: PRK09134
272568008186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568008187	NAD(P) binding site [chemical binding]; other site
272568008188	active site
272568008189	Dihydroneopterin aldolase; Region: FolB; smart00905
272568008190	active site
272568008191	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
272568008192	TIGR02300 family protein; Region: FYDLN_acid
272568008193	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
272568008194	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
272568008195	hinge; other site
272568008196	active site
272568008197	cytidylate kinase; Provisional; Region: cmk; PRK00023
272568008198	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
272568008199	CMP-binding site; other site
272568008200	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
272568008201	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
272568008202	RNA binding site [nucleotide binding]; other site
272568008203	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
272568008204	RNA binding site [nucleotide binding]; other site
272568008205	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
272568008206	RNA binding site [nucleotide binding]; other site
272568008207	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
272568008208	RNA binding site [nucleotide binding]; other site
272568008209	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
272568008210	RNA binding site [nucleotide binding]; other site
272568008211	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
272568008212	RNA binding site [nucleotide binding]; other site
272568008213	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
272568008214	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
272568008215	active site
272568008216	iron coordination sites [ion binding]; other site
272568008217	substrate binding pocket [chemical binding]; other site
272568008218	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
272568008219	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
272568008220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008221	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568008222	putative substrate translocation pore; other site
272568008223	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568008224	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568008225	active site
272568008226	catalytic tetrad [active]
272568008227	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
272568008228	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
272568008229	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
272568008230	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
272568008231	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
272568008232	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
272568008233	Beta-lactamase; Region: Beta-lactamase; pfam00144
272568008234	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
272568008235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
272568008236	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
272568008237	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
272568008238	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
272568008239	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
272568008240	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
272568008241	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
272568008242	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568008243	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
272568008244	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
272568008245	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
272568008246	heme exporter protein CcmC; Region: ccmC; TIGR01191
272568008247	YciI-like protein; Reviewed; Region: PRK12863
272568008248	EVE domain; Region: EVE; pfam01878
272568008249	EcsC protein family; Region: EcsC; pfam12787
272568008250	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
272568008251	dimerization interface [polypeptide binding]; other site
272568008252	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
272568008253	ligand binding site [chemical binding]; other site
272568008254	NADP binding site [chemical binding]; other site
272568008255	catalytic site [active]
272568008256	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
272568008257	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
272568008258	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
272568008259	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
272568008260	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
272568008261	catalytic triad [active]
272568008262	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
272568008263	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
272568008264	metal binding triad; other site
272568008265	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
272568008266	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
272568008267	metal binding triad; other site
272568008268	Protein of unknown function; Region: DUF3971; pfam13116
272568008269	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
272568008270	RmuC family; Region: RmuC; pfam02646
272568008271	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568008272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568008273	active site
272568008274	phosphorylation site [posttranslational modification]
272568008275	intermolecular recognition site; other site
272568008276	dimerization interface [polypeptide binding]; other site
272568008277	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568008278	DNA binding site [nucleotide binding]
272568008279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
272568008280	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
272568008281	dimerization interface [polypeptide binding]; other site
272568008282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568008283	ATP binding site [chemical binding]; other site
272568008284	Mg2+ binding site [ion binding]; other site
272568008285	G-X-G motif; other site
272568008286	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
272568008287	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568008288	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568008289	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568008290	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568008291	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
272568008292	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
272568008293	23S rRNA interface [nucleotide binding]; other site
272568008294	L7/L12 interface [polypeptide binding]; other site
272568008295	putative thiostrepton binding site; other site
272568008296	L25 interface [polypeptide binding]; other site
272568008297	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
272568008298	mRNA/rRNA interface [nucleotide binding]; other site
272568008299	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
272568008300	23S rRNA interface [nucleotide binding]; other site
272568008301	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
272568008302	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
272568008303	L11 interface [polypeptide binding]; other site
272568008304	putative EF-Tu interaction site [polypeptide binding]; other site
272568008305	putative EF-G interaction site [polypeptide binding]; other site
272568008306	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
272568008307	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
272568008308	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
272568008309	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
272568008310	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
272568008311	RPB12 interaction site [polypeptide binding]; other site
272568008312	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
272568008313	RPB1 interaction site [polypeptide binding]; other site
272568008314	RPB11 interaction site [polypeptide binding]; other site
272568008315	RPB10 interaction site [polypeptide binding]; other site
272568008316	RPB3 interaction site [polypeptide binding]; other site
272568008317	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
272568008318	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
272568008319	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
272568008320	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
272568008321	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
272568008322	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
272568008323	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
272568008324	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
272568008325	DNA binding site [nucleotide binding]
272568008326	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
272568008327	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
272568008328	S17 interaction site [polypeptide binding]; other site
272568008329	S8 interaction site; other site
272568008330	16S rRNA interaction site [nucleotide binding]; other site
272568008331	streptomycin interaction site [chemical binding]; other site
272568008332	23S rRNA interaction site [nucleotide binding]; other site
272568008333	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
272568008334	30S ribosomal protein S7; Validated; Region: PRK05302
272568008335	elongation factor Tu; Reviewed; Region: PRK00049
272568008336	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
272568008337	G1 box; other site
272568008338	GEF interaction site [polypeptide binding]; other site
272568008339	GTP/Mg2+ binding site [chemical binding]; other site
272568008340	Switch I region; other site
272568008341	G2 box; other site
272568008342	G3 box; other site
272568008343	Switch II region; other site
272568008344	G4 box; other site
272568008345	G5 box; other site
272568008346	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
272568008347	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
272568008348	Antibiotic Binding Site [chemical binding]; other site
272568008349	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
272568008350	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
272568008351	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
272568008352	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
272568008353	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
272568008354	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
272568008355	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
272568008356	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
272568008357	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
272568008358	putative translocon binding site; other site
272568008359	protein-rRNA interface [nucleotide binding]; other site
272568008360	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
272568008361	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
272568008362	G-X-X-G motif; other site
272568008363	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
272568008364	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
272568008365	23S rRNA interface [nucleotide binding]; other site
272568008366	5S rRNA interface [nucleotide binding]; other site
272568008367	putative antibiotic binding site [chemical binding]; other site
272568008368	L25 interface [polypeptide binding]; other site
272568008369	L27 interface [polypeptide binding]; other site
272568008370	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
272568008371	23S rRNA interface [nucleotide binding]; other site
272568008372	putative translocon interaction site; other site
272568008373	signal recognition particle (SRP54) interaction site; other site
272568008374	L23 interface [polypeptide binding]; other site
272568008375	trigger factor interaction site; other site
272568008376	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
272568008377	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
272568008378	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
272568008379	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
272568008380	RNA binding site [nucleotide binding]; other site
272568008381	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
272568008382	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
272568008383	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
272568008384	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
272568008385	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
272568008386	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
272568008387	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
272568008388	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
272568008389	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
272568008390	5S rRNA interface [nucleotide binding]; other site
272568008391	L5 interface [polypeptide binding]; other site
272568008392	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
272568008393	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
272568008394	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
272568008395	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
272568008396	23S rRNA binding site [nucleotide binding]; other site
272568008397	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
272568008398	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
272568008399	SecY translocase; Region: SecY; pfam00344
272568008400	adenylate kinase; Reviewed; Region: adk; PRK00279
272568008401	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
272568008402	AMP-binding site [chemical binding]; other site
272568008403	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
272568008404	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
272568008405	30S ribosomal protein S13; Region: bact_S13; TIGR03631
272568008406	30S ribosomal protein S11; Validated; Region: PRK05309
272568008407	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
272568008408	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
272568008409	alphaNTD - beta interaction site [polypeptide binding]; other site
272568008410	alphaNTD homodimer interface [polypeptide binding]; other site
272568008411	alphaNTD - beta' interaction site [polypeptide binding]; other site
272568008412	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
272568008413	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
272568008414	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
272568008415	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
272568008416	NAD binding site [chemical binding]; other site
272568008417	substrate binding site [chemical binding]; other site
272568008418	homodimer interface [polypeptide binding]; other site
272568008419	active site
272568008420	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
272568008421	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
272568008422	substrate binding site; other site
272568008423	tetramer interface; other site
272568008424	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
272568008425	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
272568008426	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
272568008427	NADP binding site [chemical binding]; other site
272568008428	active site
272568008429	putative substrate binding site [chemical binding]; other site
272568008430	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
272568008431	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
272568008432	Ligand binding site; other site
272568008433	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
272568008434	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
272568008435	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
272568008436	Methyltransferase domain; Region: Methyltransf_24; pfam13578
272568008437	Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143
272568008438	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
272568008439	Probable Catalytic site; other site
272568008440	metal-binding site
272568008441	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
272568008442	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
272568008443	Probable Catalytic site; other site
272568008444	metal-binding site
272568008445	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
272568008446	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
272568008447	Ligand binding site; other site
272568008448	Putative Catalytic site; other site
272568008449	DXD motif; other site
272568008450	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
272568008451	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
272568008452	Protein export membrane protein; Region: SecD_SecF; cl14618
272568008453	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
272568008454	Protein export membrane protein; Region: SecD_SecF; cl14618
272568008455	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
272568008456	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568008457	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568008458	CsbD-like; Region: CsbD; pfam05532
272568008459	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
272568008460	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
272568008461	RNA/DNA hybrid binding site [nucleotide binding]; other site
272568008462	active site
272568008463	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
272568008464	DNA methylase; Region: N6_N4_Mtase; pfam01555
272568008465	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
272568008466	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
272568008467	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
272568008468	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
272568008469	conserved cys residue [active]
272568008470	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
272568008471	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
272568008472	Protein of unknown function DUF58; Region: DUF58; pfam01882
272568008473	MoxR-like ATPases [General function prediction only]; Region: COG0714
272568008474	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
272568008475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
272568008476	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
272568008477	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
272568008478	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
272568008479	active site
272568008480	NTP binding site [chemical binding]; other site
272568008481	metal binding triad [ion binding]; metal-binding site
272568008482	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
272568008483	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
272568008484	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
272568008485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568008486	Walker A/P-loop; other site
272568008487	ATP binding site [chemical binding]; other site
272568008488	Q-loop/lid; other site
272568008489	ABC transporter signature motif; other site
272568008490	Walker B; other site
272568008491	D-loop; other site
272568008492	H-loop/switch region; other site
272568008493	HlyD family secretion protein; Region: HlyD; pfam00529
272568008494	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568008495	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568008496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008497	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568008498	putative substrate translocation pore; other site
272568008499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008500	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
272568008501	nudix motif; other site
272568008502	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
272568008503	putative active site [active]
272568008504	Ap4A binding site [chemical binding]; other site
272568008505	nudix motif; other site
272568008506	putative metal binding site [ion binding]; other site
272568008507	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
272568008508	C-terminal peptidase (prc); Region: prc; TIGR00225
272568008509	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
272568008510	protein binding site [polypeptide binding]; other site
272568008511	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
272568008512	Catalytic dyad [active]
272568008513	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
272568008514	Peptidase family M23; Region: Peptidase_M23; pfam01551
272568008515	phosphoglyceromutase; Provisional; Region: PRK05434
272568008516	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
272568008517	SelR domain; Region: SelR; pfam01641
272568008518	methionine sulfoxide reductase B; Provisional; Region: PRK00222
272568008519	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
272568008520	active site
272568008521	Dodecin; Region: Dodecin; pfam07311
272568008522	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
272568008523	oligomeric interface; other site
272568008524	putative active site [active]
272568008525	homodimer interface [polypeptide binding]; other site
272568008526	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
272568008527	threonine dehydratase; Provisional; Region: PRK07334
272568008528	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
272568008529	tetramer interface [polypeptide binding]; other site
272568008530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568008531	catalytic residue [active]
272568008532	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
272568008533	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
272568008534	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
272568008535	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
272568008536	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
272568008537	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
272568008538	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
272568008539	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
272568008540	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
272568008541	ATP-grasp domain; Region: ATP-grasp_4; cl17255
272568008542	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
272568008543	IMP binding site; other site
272568008544	dimer interface [polypeptide binding]; other site
272568008545	partial ornithine binding site; other site
272568008546	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
272568008547	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
272568008548	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
272568008549	catalytic site [active]
272568008550	subunit interface [polypeptide binding]; other site
272568008551	Yqey-like protein; Region: YqeY; cl17540
272568008552	DNA primase; Validated; Region: dnaG; PRK05667
272568008553	CHC2 zinc finger; Region: zf-CHC2; pfam01807
272568008554	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
272568008555	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
272568008556	active site
272568008557	metal binding site [ion binding]; metal-binding site
272568008558	interdomain interaction site; other site
272568008559	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
272568008560	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
272568008561	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
272568008562	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
272568008563	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
272568008564	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
272568008565	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
272568008566	DNA binding residues [nucleotide binding]
272568008567	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
272568008568	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
272568008569	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
272568008570	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
272568008571	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
272568008572	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
272568008573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568008574	S-adenosylmethionine binding site [chemical binding]; other site
272568008575	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
272568008576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568008577	S-adenosylmethionine binding site [chemical binding]; other site
272568008578	SurA N-terminal domain; Region: SurA_N; pfam09312
272568008579	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
272568008580	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
272568008581	OstA-like protein; Region: OstA; cl00844
272568008582	Organic solvent tolerance protein; Region: OstA_C; pfam04453
272568008583	Predicted permeases [General function prediction only]; Region: COG0795
272568008584	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
272568008585	Predicted permeases [General function prediction only]; Region: COG0795
272568008586	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
272568008587	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
272568008588	FAD binding domain; Region: FAD_binding_4; pfam01565
272568008589	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
272568008590	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
272568008591	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
272568008592	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
272568008593	active site
272568008594	multifunctional aminopeptidase A; Provisional; Region: PRK00913
272568008595	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
272568008596	interface (dimer of trimers) [polypeptide binding]; other site
272568008597	Substrate-binding/catalytic site; other site
272568008598	Zn-binding sites [ion binding]; other site
272568008599	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
272568008600	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568008601	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
272568008602	DNA polymerase III subunit chi; Validated; Region: PRK05728
272568008603	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568008604	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568008605	active site
272568008606	catalytic tetrad [active]
272568008607	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
272568008608	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
272568008609	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
272568008610	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
272568008611	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
272568008612	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
272568008613	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
272568008614	Methyltransferase domain; Region: Methyltransf_11; pfam08241
272568008615	Methyltransferase domain; Region: Methyltransf_23; pfam13489
272568008616	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
272568008617	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
272568008618	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
272568008619	NAD(P) binding site [chemical binding]; other site
272568008620	homotetramer interface [polypeptide binding]; other site
272568008621	homodimer interface [polypeptide binding]; other site
272568008622	active site
272568008623	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
272568008624	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
272568008625	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
272568008626	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
272568008627	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
272568008628	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
272568008629	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
272568008630	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
272568008631	putative acyl-acceptor binding pocket; other site
272568008632	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
272568008633	putative active site [active]
272568008634	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
272568008635	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
272568008636	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568008637	Walker A/P-loop; other site
272568008638	ATP binding site [chemical binding]; other site
272568008639	Q-loop/lid; other site
272568008640	ABC transporter signature motif; other site
272568008641	Walker B; other site
272568008642	D-loop; other site
272568008643	H-loop/switch region; other site
272568008644	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
272568008645	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
272568008646	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
272568008647	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
272568008648	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
272568008649	dimerization interface [polypeptide binding]; other site
272568008650	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
272568008651	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
272568008652	dimer interface [polypeptide binding]; other site
272568008653	putative CheW interface [polypeptide binding]; other site
272568008654	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
272568008655	putative binding surface; other site
272568008656	active site
272568008657	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568008658	ATP binding site [chemical binding]; other site
272568008659	Mg2+ binding site [ion binding]; other site
272568008660	G-X-G motif; other site
272568008661	Response regulator receiver domain; Region: Response_reg; pfam00072
272568008662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568008663	active site
272568008664	phosphorylation site [posttranslational modification]
272568008665	intermolecular recognition site; other site
272568008666	dimerization interface [polypeptide binding]; other site
272568008667	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
272568008668	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568008669	active site
272568008670	phosphorylation site [posttranslational modification]
272568008671	intermolecular recognition site; other site
272568008672	dimerization interface [polypeptide binding]; other site
272568008673	CheB methylesterase; Region: CheB_methylest; pfam01339
272568008674	Response regulator receiver domain; Region: Response_reg; pfam00072
272568008675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568008676	active site
272568008677	phosphorylation site [posttranslational modification]
272568008678	intermolecular recognition site; other site
272568008679	dimerization interface [polypeptide binding]; other site
272568008680	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
272568008681	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568008682	dimer interface [polypeptide binding]; other site
272568008683	phosphorylation site [posttranslational modification]
272568008684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568008685	ATP binding site [chemical binding]; other site
272568008686	Mg2+ binding site [ion binding]; other site
272568008687	G-X-G motif; other site
272568008688	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
272568008689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568008690	active site
272568008691	phosphorylation site [posttranslational modification]
272568008692	intermolecular recognition site; other site
272568008693	dimerization interface [polypeptide binding]; other site
272568008694	PAS fold; Region: PAS_4; pfam08448
272568008695	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
272568008696	dimer interface [polypeptide binding]; other site
272568008697	phosphorylation site [posttranslational modification]
272568008698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568008699	ATP binding site [chemical binding]; other site
272568008700	Mg2+ binding site [ion binding]; other site
272568008701	G-X-G motif; other site
272568008702	Response regulator receiver domain; Region: Response_reg; pfam00072
272568008703	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568008704	active site
272568008705	phosphorylation site [posttranslational modification]
272568008706	intermolecular recognition site; other site
272568008707	dimerization interface [polypeptide binding]; other site
272568008708	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
272568008709	active site
272568008710	HslU subunit interaction site [polypeptide binding]; other site
272568008711	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
272568008712	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568008713	Walker A motif; other site
272568008714	ATP binding site [chemical binding]; other site
272568008715	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
272568008716	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
272568008717	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
272568008718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008719	Major Facilitator Superfamily; Region: MFS_1; pfam07690
272568008720	putative substrate translocation pore; other site
272568008721	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008722	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
272568008723	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
272568008724	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
272568008725	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
272568008726	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
272568008727	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
272568008728	catalytic loop [active]
272568008729	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
272568008730	iron binding site [ion binding]; other site
272568008731	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
272568008732	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
272568008733	Cytochrome c; Region: Cytochrom_C; pfam00034
272568008734	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
272568008735	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
272568008736	Trp docking motif [polypeptide binding]; other site
272568008737	putative active site [active]
272568008738	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
272568008739	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
272568008740	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
272568008741	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
272568008742	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
272568008743	23S rRNA binding site [nucleotide binding]; other site
272568008744	L21 binding site [polypeptide binding]; other site
272568008745	L13 binding site [polypeptide binding]; other site
272568008746	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
272568008747	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
272568008748	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
272568008749	dimer interface [polypeptide binding]; other site
272568008750	motif 1; other site
272568008751	active site
272568008752	motif 2; other site
272568008753	motif 3; other site
272568008754	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
272568008755	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
272568008756	putative tRNA-binding site [nucleotide binding]; other site
272568008757	B3/4 domain; Region: B3_4; pfam03483
272568008758	tRNA synthetase B5 domain; Region: B5; smart00874
272568008759	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
272568008760	dimer interface [polypeptide binding]; other site
272568008761	motif 1; other site
272568008762	motif 3; other site
272568008763	motif 2; other site
272568008764	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
272568008765	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
272568008766	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
272568008767	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
272568008768	classical (c) SDRs; Region: SDR_c; cd05233
272568008769	NAD(P) binding site [chemical binding]; other site
272568008770	active site
272568008771	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
272568008772	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
272568008773	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
272568008774	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
272568008775	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
272568008776	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
272568008777	putative active site [active]
272568008778	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
272568008779	putative ADP-binding pocket [chemical binding]; other site
272568008780	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568008781	dihydroorotase; Validated; Region: PRK09060
272568008782	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
272568008783	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
272568008784	active site
272568008785	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
272568008786	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
272568008787	Trp docking motif [polypeptide binding]; other site
272568008788	active site
272568008789	PQQ-like domain; Region: PQQ_2; pfam13360
272568008790	GTP-binding protein Der; Reviewed; Region: PRK00093
272568008791	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
272568008792	G1 box; other site
272568008793	GTP/Mg2+ binding site [chemical binding]; other site
272568008794	Switch I region; other site
272568008795	G2 box; other site
272568008796	Switch II region; other site
272568008797	G3 box; other site
272568008798	G4 box; other site
272568008799	G5 box; other site
272568008800	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
272568008801	G1 box; other site
272568008802	GTP/Mg2+ binding site [chemical binding]; other site
272568008803	Switch I region; other site
272568008804	G2 box; other site
272568008805	G3 box; other site
272568008806	Switch II region; other site
272568008807	G4 box; other site
272568008808	G5 box; other site
272568008809	GntP family permease; Region: GntP_permease; pfam02447
272568008810	fructuronate transporter; Provisional; Region: PRK10034; cl15264
272568008811	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
272568008812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008813	putative substrate translocation pore; other site
272568008814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008815	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
272568008816	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
272568008817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008818	putative substrate translocation pore; other site
272568008819	Predicted methyltransferase [General function prediction only]; Region: COG3897
272568008820	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
272568008821	UbiA prenyltransferase family; Region: UbiA; pfam01040
272568008822	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
272568008823	glutamate--cysteine ligase; Region: PLN02611
272568008824	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
272568008825	diiron binding motif [ion binding]; other site
272568008826	Uncharacterized conserved protein [Function unknown]; Region: COG1633
272568008827	CCC1-related protein family; Region: CCC1_like_1; cd02437
272568008828	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
272568008829	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
272568008830	Predicted methyltransferases [General function prediction only]; Region: COG0313
272568008831	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
272568008832	putative SAM binding site [chemical binding]; other site
272568008833	putative homodimer interface [polypeptide binding]; other site
272568008834	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
272568008835	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
272568008836	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
272568008837	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
272568008838	putative acyl-acceptor binding pocket; other site
272568008839	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
272568008840	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
272568008841	putative acyl-acceptor binding pocket; other site
272568008842	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
272568008843	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
272568008844	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
272568008845	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
272568008846	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
272568008847	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
272568008848	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
272568008849	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
272568008850	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
272568008851	G1 box; other site
272568008852	GTP/Mg2+ binding site [chemical binding]; other site
272568008853	G2 box; other site
272568008854	Switch I region; other site
272568008855	G3 box; other site
272568008856	Switch II region; other site
272568008857	G4 box; other site
272568008858	G5 box; other site
272568008859	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
272568008860	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
272568008861	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
272568008862	ligand-binding site [chemical binding]; other site
272568008863	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
272568008864	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
272568008865	Active Sites [active]
272568008866	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
272568008867	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
272568008868	Active Sites [active]
272568008869	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
272568008870	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
272568008871	Ligand Binding Site [chemical binding]; other site
272568008872	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
272568008873	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
272568008874	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
272568008875	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
272568008876	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
272568008877	NAD binding site [chemical binding]; other site
272568008878	homotetramer interface [polypeptide binding]; other site
272568008879	homodimer interface [polypeptide binding]; other site
272568008880	substrate binding site [chemical binding]; other site
272568008881	active site
272568008882	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
272568008883	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
272568008884	Tetramer interface [polypeptide binding]; other site
272568008885	active site
272568008886	FMN-binding site [chemical binding]; other site
272568008887	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
272568008888	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
272568008889	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
272568008890	Methyltransferase domain; Region: Methyltransf_31; pfam13847
272568008891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568008892	S-adenosylmethionine binding site [chemical binding]; other site
272568008893	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
272568008894	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
272568008895	DEAD-like helicases superfamily; Region: DEXDc; smart00487
272568008896	ATP binding site [chemical binding]; other site
272568008897	Mg++ binding site [ion binding]; other site
272568008898	motif III; other site
272568008899	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568008900	nucleotide binding region [chemical binding]; other site
272568008901	ATP-binding site [chemical binding]; other site
272568008902	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
272568008903	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
272568008904	Walker A/P-loop; other site
272568008905	ATP binding site [chemical binding]; other site
272568008906	Q-loop/lid; other site
272568008907	ABC transporter signature motif; other site
272568008908	Walker B; other site
272568008909	D-loop; other site
272568008910	H-loop/switch region; other site
272568008911	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
272568008912	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
272568008913	polyol permease family; Region: 2A0118; TIGR00897
272568008914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008915	putative substrate translocation pore; other site
272568008916	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
272568008917	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
272568008918	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
272568008919	putative active site [active]
272568008920	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
272568008921	active site
272568008922	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
272568008923	dimer interface [polypeptide binding]; other site
272568008924	putative tRNA-binding site [nucleotide binding]; other site
272568008925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568008926	H+ Antiporter protein; Region: 2A0121; TIGR00900
272568008927	putative substrate translocation pore; other site
272568008928	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
272568008929	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
272568008930	NMT1/THI5 like; Region: NMT1; pfam09084
272568008931	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
272568008932	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
272568008933	hydrophobic ligand binding site; other site
272568008934	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
272568008935	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568008936	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
272568008937	TM-ABC transporter signature motif; other site
272568008938	TM-ABC transporter signature motif; other site
272568008939	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
272568008940	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
272568008941	TM-ABC transporter signature motif; other site
272568008942	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
272568008943	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
272568008944	Walker A/P-loop; other site
272568008945	ATP binding site [chemical binding]; other site
272568008946	Q-loop/lid; other site
272568008947	ABC transporter signature motif; other site
272568008948	Walker B; other site
272568008949	D-loop; other site
272568008950	H-loop/switch region; other site
272568008951	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
272568008952	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
272568008953	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
272568008954	putative ligand binding site [chemical binding]; other site
272568008955	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
272568008956	Isochorismatase family; Region: Isochorismatase; pfam00857
272568008957	catalytic triad [active]
272568008958	metal binding site [ion binding]; metal-binding site
272568008959	conserved cis-peptide bond; other site
272568008960	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
272568008961	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
272568008962	[2Fe-2S] cluster binding site [ion binding]; other site
272568008963	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
272568008964	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
272568008965	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
272568008966	N-terminal domain interface [polypeptide binding]; other site
272568008967	dimer interface [polypeptide binding]; other site
272568008968	substrate binding pocket (H-site) [chemical binding]; other site
272568008969	Predicted transcriptional regulator [Transcription]; Region: COG1959
272568008970	Transcriptional regulator; Region: Rrf2; pfam02082
272568008971	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
272568008972	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
272568008973	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568008974	NAD(P) binding site [chemical binding]; other site
272568008975	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
272568008976	Domain of unknown function DUF21; Region: DUF21; pfam01595
272568008977	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
272568008978	Transporter associated domain; Region: CorC_HlyC; smart01091
272568008979	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
272568008980	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
272568008981	nucleotide binding pocket [chemical binding]; other site
272568008982	K-X-D-G motif; other site
272568008983	catalytic site [active]
272568008984	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
272568008985	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
272568008986	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
272568008987	Dimer interface [polypeptide binding]; other site
272568008988	BRCT sequence motif; other site
272568008989	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
272568008990	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
272568008991	Walker A/P-loop; other site
272568008992	ATP binding site [chemical binding]; other site
272568008993	Q-loop/lid; other site
272568008994	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
272568008995	ABC transporter signature motif; other site
272568008996	Walker B; other site
272568008997	D-loop; other site
272568008998	H-loop/switch region; other site
272568008999	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
272568009000	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
272568009001	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
272568009002	cell division protein FtsZ; Validated; Region: PRK09330
272568009003	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
272568009004	nucleotide binding site [chemical binding]; other site
272568009005	SulA interaction site; other site
272568009006	Cell division protein FtsA; Region: FtsA; smart00842
272568009007	cell division protein FtsA; Region: ftsA; TIGR01174
272568009008	Cell division protein FtsA; Region: FtsA; pfam14450
272568009009	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
272568009010	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
272568009011	Cell division protein FtsQ; Region: FtsQ; pfam03799
272568009012	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
272568009013	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
272568009014	ATP-grasp domain; Region: ATP-grasp_4; cl17255
272568009015	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
272568009016	FAD binding domain; Region: FAD_binding_4; pfam01565
272568009017	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
272568009018	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
272568009019	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
272568009020	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
272568009021	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
272568009022	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
272568009023	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
272568009024	active site
272568009025	homodimer interface [polypeptide binding]; other site
272568009026	cell division protein FtsW; Region: ftsW; TIGR02614
272568009027	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
272568009028	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
272568009029	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
272568009030	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
272568009031	Mg++ binding site [ion binding]; other site
272568009032	putative catalytic motif [active]
272568009033	putative substrate binding site [chemical binding]; other site
272568009034	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
272568009035	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
272568009036	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
272568009037	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
272568009038	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
272568009039	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
272568009040	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
272568009041	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
272568009042	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
272568009043	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
272568009044	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
272568009045	MraW methylase family; Region: Methyltransf_5; cl17771
272568009046	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
272568009047	cell division protein MraZ; Reviewed; Region: PRK00326
272568009048	MraZ protein; Region: MraZ; pfam02381
272568009049	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
272568009050	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
272568009051	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
272568009052	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
272568009053	[2Fe-2S] cluster binding site [ion binding]; other site
272568009054	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
272568009055	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
272568009056	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
272568009057	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
272568009058	gamma-glutamyl kinase; Provisional; Region: PRK05429
272568009059	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
272568009060	nucleotide binding site [chemical binding]; other site
272568009061	homotetrameric interface [polypeptide binding]; other site
272568009062	putative phosphate binding site [ion binding]; other site
272568009063	putative allosteric binding site; other site
272568009064	PUA domain; Region: PUA; pfam01472
272568009065	GTPase CgtA; Reviewed; Region: obgE; PRK12299
272568009066	GTP1/OBG; Region: GTP1_OBG; pfam01018
272568009067	Obg GTPase; Region: Obg; cd01898
272568009068	G1 box; other site
272568009069	GTP/Mg2+ binding site [chemical binding]; other site
272568009070	Switch I region; other site
272568009071	G2 box; other site
272568009072	G3 box; other site
272568009073	Switch II region; other site
272568009074	G4 box; other site
272568009075	G5 box; other site
272568009076	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
272568009077	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
272568009078	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
272568009079	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
272568009080	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
272568009081	active site
272568009082	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
272568009083	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
272568009084	metal binding site [ion binding]; metal-binding site
272568009085	active site
272568009086	I-site; other site
272568009087	guanine deaminase; Provisional; Region: PRK09228
272568009088	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
272568009089	active site
272568009090	Fusaric acid resistance protein family; Region: FUSC; pfam04632
272568009091	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
272568009092	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
272568009093	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
272568009094	Fe-S cluster binding site [ion binding]; other site
272568009095	active site
272568009096	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
272568009097	C-terminal domain interface [polypeptide binding]; other site
272568009098	GSH binding site (G-site) [chemical binding]; other site
272568009099	dimer interface [polypeptide binding]; other site
272568009100	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
272568009101	N-terminal domain interface [polypeptide binding]; other site
272568009102	dimer interface [polypeptide binding]; other site
272568009103	substrate binding pocket (H-site) [chemical binding]; other site
272568009104	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
272568009105	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
272568009106	substrate binding site [chemical binding]; other site
272568009107	dimer interface [polypeptide binding]; other site
272568009108	ATP binding site [chemical binding]; other site
272568009109	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
272568009110	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
272568009111	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
272568009112	tandem repeat interface [polypeptide binding]; other site
272568009113	oligomer interface [polypeptide binding]; other site
272568009114	active site residues [active]
272568009115	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
272568009116	IHF dimer interface [polypeptide binding]; other site
272568009117	IHF - DNA interface [nucleotide binding]; other site
272568009118	Transcriptional regulator [Transcription]; Region: LysR; COG0583
272568009119	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
272568009120	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
272568009121	putative effector binding pocket; other site
272568009122	dimerization interface [polypeptide binding]; other site
272568009123	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
272568009124	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
272568009125	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
272568009126	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
272568009127	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
272568009128	AsnC family; Region: AsnC_trans_reg; pfam01037
272568009129	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
272568009130	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
272568009131	Ligand binding site; other site
272568009132	Putative Catalytic site; other site
272568009133	DXD motif; other site
272568009134	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
272568009135	Response regulator receiver domain; Region: Response_reg; pfam00072
272568009136	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568009137	active site
272568009138	phosphorylation site [posttranslational modification]
272568009139	intermolecular recognition site; other site
272568009140	dimerization interface [polypeptide binding]; other site
272568009141	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
272568009142	nudix motif; other site
272568009143	Predicted acyl esterases [General function prediction only]; Region: COG2936
272568009144	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
272568009145	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
272568009146	GMP synthase; Reviewed; Region: guaA; PRK00074
272568009147	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
272568009148	AMP/PPi binding site [chemical binding]; other site
272568009149	candidate oxyanion hole; other site
272568009150	catalytic triad [active]
272568009151	potential glutamine specificity residues [chemical binding]; other site
272568009152	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
272568009153	ATP Binding subdomain [chemical binding]; other site
272568009154	Ligand Binding sites [chemical binding]; other site
272568009155	Dimerization subdomain; other site
272568009156	Virulence factor SrfB; Region: SrfB; pfam07520
272568009157	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
272568009158	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
272568009159	metal ion-dependent adhesion site (MIDAS); other site
272568009160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568009161	Walker A/P-loop; other site
272568009162	ATP binding site [chemical binding]; other site
272568009163	Q-loop/lid; other site
272568009164	ABC transporter signature motif; other site
272568009165	Walker B; other site
272568009166	D-loop; other site
272568009167	H-loop/switch region; other site
272568009168	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
272568009169	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
272568009170	Transposase; Region: DEDD_Tnp_IS110; pfam01548
272568009171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
272568009172	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
272568009173	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
272568009174	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
272568009175	putative ligand binding site [chemical binding]; other site
272568009176	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
272568009177	Helix-turn-helix domain; Region: HTH_18; pfam12833
272568009178	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
272568009179	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
272568009180	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
272568009181	inhibitor binding site; inhibition site
272568009182	catalytic Zn binding site [ion binding]; other site
272568009183	structural Zn binding site [ion binding]; other site
272568009184	NADP binding site [chemical binding]; other site
272568009185	tetramer interface [polypeptide binding]; other site
272568009186	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
272568009187	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
272568009188	active site
272568009189	substrate binding site [chemical binding]; other site
272568009190	metal binding site [ion binding]; metal-binding site
272568009191	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
272568009192	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
272568009193	catalytic nucleophile [active]
272568009194	phosphoglucomutase; Validated; Region: PRK07564
272568009195	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
272568009196	active site
272568009197	substrate binding site [chemical binding]; other site
272568009198	metal binding site [ion binding]; metal-binding site
272568009199	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
272568009200	ArsC family; Region: ArsC; pfam03960
272568009201	putative catalytic residues [active]
272568009202	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
272568009203	metal-binding site [ion binding]
272568009204	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
272568009205	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
272568009206	metal-binding site [ion binding]
272568009207	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
272568009208	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
272568009209	metal-binding site [ion binding]
272568009210	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
272568009211	hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367
272568009212	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
272568009213	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568009214	FeS/SAM binding site; other site
272568009215	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
272568009216	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
272568009217	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
272568009218	active site
272568009219	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
272568009220	active site
272568009221	HIGH motif; other site
272568009222	nucleotide binding site [chemical binding]; other site
272568009223	active site
272568009224	KMSKS motif; other site
272568009225	aspartate aminotransferase; Provisional; Region: PRK05764
272568009226	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568009227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568009228	homodimer interface [polypeptide binding]; other site
272568009229	catalytic residue [active]
272568009230	aspartate aminotransferase; Provisional; Region: PRK05764
272568009231	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
272568009232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
272568009233	homodimer interface [polypeptide binding]; other site
272568009234	catalytic residue [active]
272568009235	Transposase, Mutator family; Region: Transposase_mut; pfam00872
272568009236	MULE transposase domain; Region: MULE; pfam10551
272568009237	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
272568009238	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
272568009239	Walker A/P-loop; other site
272568009240	ATP binding site [chemical binding]; other site
272568009241	Q-loop/lid; other site
272568009242	ABC transporter signature motif; other site
272568009243	Walker B; other site
272568009244	D-loop; other site
272568009245	H-loop/switch region; other site
272568009246	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
272568009247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568009248	putative substrate translocation pore; other site
272568009249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
272568009250	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
272568009251	AAA domain; Region: AAA_33; pfam13671
272568009252	ATP-binding site [chemical binding]; other site
272568009253	Gluconate-6-phosphate binding site [chemical binding]; other site
272568009254	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
272568009255	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
272568009256	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
272568009257	TAP-like protein; Region: Abhydrolase_4; pfam08386
272568009258	FtsJ-like methyltransferase; Region: FtsJ; cl17430
272568009259	Winged helix-turn helix; Region: HTH_29; pfam13551
272568009260	Integrase core domain; Region: rve; pfam00665
272568009261	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
272568009262	Integrase core domain; Region: rve_3; pfam13683
272568009263	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
272568009264	catalytic residues [active]
272568009265	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
272568009266	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
272568009267	active site
272568009268	Zn binding site [ion binding]; other site
272568009269	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
272568009270	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
272568009271	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
272568009272	Predicted membrane protein [Function unknown]; Region: COG1297
272568009273	putative oligopeptide transporter, OPT family; Region: TIGR00733
272568009274	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
272568009275	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
272568009276	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
272568009277	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
272568009278	putative active site [active]
272568009279	putative substrate binding site [chemical binding]; other site
272568009280	ATP binding site [chemical binding]; other site
272568009281	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
272568009282	RNA/DNA hybrid binding site [nucleotide binding]; other site
272568009283	active site
272568009284	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
272568009285	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568009286	Walker A/P-loop; other site
272568009287	ATP binding site [chemical binding]; other site
272568009288	Q-loop/lid; other site
272568009289	ABC transporter signature motif; other site
272568009290	Walker B; other site
272568009291	D-loop; other site
272568009292	H-loop/switch region; other site
272568009293	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
272568009294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568009295	putative PBP binding loops; other site
272568009296	dimer interface [polypeptide binding]; other site
272568009297	ABC-ATPase subunit interface; other site
272568009298	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
272568009299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568009300	dimer interface [polypeptide binding]; other site
272568009301	conserved gate region; other site
272568009302	putative PBP binding loops; other site
272568009303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
272568009304	ABC-ATPase subunit interface; other site
272568009305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568009306	dimer interface [polypeptide binding]; other site
272568009307	conserved gate region; other site
272568009308	putative PBP binding loops; other site
272568009309	ABC-ATPase subunit interface; other site
272568009310	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
272568009311	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
272568009312	Walker A/P-loop; other site
272568009313	ATP binding site [chemical binding]; other site
272568009314	Q-loop/lid; other site
272568009315	ABC transporter signature motif; other site
272568009316	Walker B; other site
272568009317	D-loop; other site
272568009318	H-loop/switch region; other site
272568009319	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
272568009320	PhoU domain; Region: PhoU; pfam01895
272568009321	PhoU domain; Region: PhoU; pfam01895
272568009322	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
272568009323	dimer interface [polypeptide binding]; other site
272568009324	signal recognition particle protein; Provisional; Region: PRK10867
272568009325	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
272568009326	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
272568009327	P loop; other site
272568009328	GTP binding site [chemical binding]; other site
272568009329	Signal peptide binding domain; Region: SRP_SPB; pfam02978
272568009330	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
272568009331	RimM N-terminal domain; Region: RimM; pfam01782
272568009332	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
272568009333	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
272568009334	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
272568009335	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
272568009336	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
272568009337	substrate binding site [chemical binding]; other site
272568009338	ligand binding site [chemical binding]; other site
272568009339	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
272568009340	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
272568009341	substrate binding site [chemical binding]; other site
272568009342	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
272568009343	tartrate dehydrogenase; Region: TTC; TIGR02089
272568009344	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
272568009345	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
272568009346	active site
272568009347	catalytic residues [active]
272568009348	metal binding site [ion binding]; metal-binding site
272568009349	COQ9; Region: COQ9; pfam08511
272568009350	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
272568009351	MarR family; Region: MarR_2; pfam12802
272568009352	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
272568009353	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568009354	active site
272568009355	phosphorylation site [posttranslational modification]
272568009356	intermolecular recognition site; other site
272568009357	dimerization interface [polypeptide binding]; other site
272568009358	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568009359	DNA binding site [nucleotide binding]
272568009360	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
272568009361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568009362	ATP binding site [chemical binding]; other site
272568009363	Mg2+ binding site [ion binding]; other site
272568009364	G-X-G motif; other site
272568009365	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
272568009366	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
272568009367	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
272568009368	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
272568009369	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
272568009370	putative phosphate acyltransferase; Provisional; Region: PRK05331
272568009371	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
272568009372	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
272568009373	dimer interface [polypeptide binding]; other site
272568009374	active site
272568009375	CoA binding pocket [chemical binding]; other site
272568009376	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
272568009377	IHF dimer interface [polypeptide binding]; other site
272568009378	IHF - DNA interface [nucleotide binding]; other site
272568009379	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
272568009380	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
272568009381	DNA binding residues [nucleotide binding]
272568009382	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
272568009383	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
272568009384	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
272568009385	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
272568009386	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
272568009387	nudix motif; other site
272568009388	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
272568009389	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
272568009390	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
272568009391	Walker A/P-loop; other site
272568009392	ATP binding site [chemical binding]; other site
272568009393	Q-loop/lid; other site
272568009394	ABC transporter signature motif; other site
272568009395	Walker B; other site
272568009396	D-loop; other site
272568009397	H-loop/switch region; other site
272568009398	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
272568009399	elongation factor G; Reviewed; Region: PRK12739
272568009400	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
272568009401	G1 box; other site
272568009402	putative GEF interaction site [polypeptide binding]; other site
272568009403	GTP/Mg2+ binding site [chemical binding]; other site
272568009404	Switch I region; other site
272568009405	G2 box; other site
272568009406	G3 box; other site
272568009407	Switch II region; other site
272568009408	G4 box; other site
272568009409	G5 box; other site
272568009410	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
272568009411	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
272568009412	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
272568009413	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
272568009414	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
272568009415	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
272568009416	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
272568009417	Protein of unknown function (DUF445); Region: DUF445; pfam04286
272568009418	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
272568009419	Transcriptional regulator; Region: Rrf2; pfam02082
272568009420	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
272568009421	putative ABC transporter; Region: ycf24; CHL00085
272568009422	FeS assembly ATPase SufC; Region: sufC; TIGR01978
272568009423	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
272568009424	Walker A/P-loop; other site
272568009425	ATP binding site [chemical binding]; other site
272568009426	Q-loop/lid; other site
272568009427	ABC transporter signature motif; other site
272568009428	Walker B; other site
272568009429	D-loop; other site
272568009430	H-loop/switch region; other site
272568009431	FeS assembly protein SufD; Region: sufD; TIGR01981
272568009432	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
272568009433	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
272568009434	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
272568009435	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568009436	catalytic residue [active]
272568009437	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
272568009438	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
272568009439	trimerization site [polypeptide binding]; other site
272568009440	active site
272568009441	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
272568009442	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
272568009443	Predicted methyltransferase [General function prediction only]; Region: COG4798
272568009444	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
272568009445	TRAM domain; Region: TRAM; cl01282
272568009446	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297
272568009447	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
272568009448	ATP binding site [chemical binding]; other site
272568009449	Mg++ binding site [ion binding]; other site
272568009450	motif III; other site
272568009451	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568009452	nucleotide binding region [chemical binding]; other site
272568009453	ATP-binding site [chemical binding]; other site
272568009454	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
272568009455	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
272568009456	Predicted integral membrane protein [Function unknown]; Region: COG5615
272568009457	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
272568009458	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
272568009459	putative ATP binding site [chemical binding]; other site
272568009460	putative substrate binding site [chemical binding]; other site
272568009461	trigger factor; Provisional; Region: tig; PRK01490
272568009462	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
272568009463	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
272568009464	Clp protease; Region: CLP_protease; pfam00574
272568009465	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
272568009466	oligomer interface [polypeptide binding]; other site
272568009467	active site residues [active]
272568009468	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
272568009469	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
272568009470	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568009471	Walker A motif; other site
272568009472	ATP binding site [chemical binding]; other site
272568009473	Walker B motif; other site
272568009474	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
272568009475	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
272568009476	Found in ATP-dependent protease La (LON); Region: LON; smart00464
272568009477	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
272568009478	Walker A motif; other site
272568009479	ATP binding site [chemical binding]; other site
272568009480	Walker B motif; other site
272568009481	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
272568009482	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
272568009483	IHF - DNA interface [nucleotide binding]; other site
272568009484	IHF dimer interface [polypeptide binding]; other site
272568009485	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
272568009486	NADH dehydrogenase subunit B; Validated; Region: PRK06411
272568009487	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
272568009488	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
272568009489	NADH dehydrogenase subunit D; Validated; Region: PRK06075
272568009490	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
272568009491	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
272568009492	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
272568009493	putative dimer interface [polypeptide binding]; other site
272568009494	[2Fe-2S] cluster binding site [ion binding]; other site
272568009495	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
272568009496	SLBB domain; Region: SLBB; pfam10531
272568009497	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
272568009498	NADH dehydrogenase subunit G; Validated; Region: PRK09130
272568009499	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
272568009500	catalytic loop [active]
272568009501	iron binding site [ion binding]; other site
272568009502	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
272568009503	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
272568009504	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
272568009505	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
272568009506	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
272568009507	4Fe-4S binding domain; Region: Fer4; cl02805
272568009508	4Fe-4S binding domain; Region: Fer4; pfam00037
272568009509	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
272568009510	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
272568009511	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
272568009512	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
272568009513	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
272568009514	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
272568009515	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
272568009516	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
272568009517	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
272568009518	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
272568009519	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
272568009520	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
272568009521	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
272568009522	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
272568009523	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
272568009524	prolyl-tRNA synthetase; Provisional; Region: PRK12325
272568009525	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
272568009526	dimer interface [polypeptide binding]; other site
272568009527	motif 1; other site
272568009528	active site
272568009529	motif 2; other site
272568009530	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
272568009531	motif 3; other site
272568009532	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
272568009533	anticodon binding site; other site
272568009534	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
272568009535	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
272568009536	FtsX-like permease family; Region: FtsX; pfam02687
272568009537	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
272568009538	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
272568009539	Walker A/P-loop; other site
272568009540	ATP binding site [chemical binding]; other site
272568009541	Q-loop/lid; other site
272568009542	ABC transporter signature motif; other site
272568009543	Walker B; other site
272568009544	D-loop; other site
272568009545	H-loop/switch region; other site
272568009546	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
272568009547	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
272568009548	putative active site [active]
272568009549	putative PHP Thumb interface [polypeptide binding]; other site
272568009550	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
272568009551	generic binding surface II; other site
272568009552	generic binding surface I; other site
272568009553	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
272568009554	rRNA interaction site [nucleotide binding]; other site
272568009555	S8 interaction site; other site
272568009556	putative laminin-1 binding site; other site
272568009557	elongation factor Ts; Provisional; Region: tsf; PRK09377
272568009558	UBA/TS-N domain; Region: UBA; pfam00627
272568009559	Elongation factor TS; Region: EF_TS; pfam00889
272568009560	Elongation factor TS; Region: EF_TS; pfam00889
272568009561	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
272568009562	Recombination protein O N terminal; Region: RecO_N; pfam11967
272568009563	Recombination protein O C terminal; Region: RecO_C; pfam02565
272568009564	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
272568009565	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
272568009566	CAP-like domain; other site
272568009567	active site
272568009568	primary dimer interface [polypeptide binding]; other site
272568009569	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
272568009570	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
272568009571	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
272568009572	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
272568009573	dimer interface [polypeptide binding]; other site
272568009574	allosteric magnesium binding site [ion binding]; other site
272568009575	active site
272568009576	aspartate-rich active site metal binding site; other site
272568009577	Schiff base residues; other site
272568009578	amino acid transporter; Region: 2A0306; TIGR00909
272568009579	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
272568009580	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
272568009581	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
272568009582	dimer interface [polypeptide binding]; other site
272568009583	active site
272568009584	glycine-pyridoxal phosphate binding site [chemical binding]; other site
272568009585	folate binding site [chemical binding]; other site
272568009586	Winged helix-turn helix; Region: HTH_29; pfam13551
272568009587	Winged helix-turn helix; Region: HTH_33; pfam13592
272568009588	DDE superfamily endonuclease; Region: DDE_3; pfam13358
272568009589	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
272568009590	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910
272568009591	putative active site [active]
272568009592	Zn binding site [ion binding]; other site
272568009593	helicase 45; Provisional; Region: PTZ00424
272568009594	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
272568009595	ATP binding site [chemical binding]; other site
272568009596	Mg++ binding site [ion binding]; other site
272568009597	motif III; other site
272568009598	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568009599	nucleotide binding region [chemical binding]; other site
272568009600	ATP-binding site [chemical binding]; other site
272568009601	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
272568009602	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
272568009603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568009604	TPR motif; other site
272568009605	Tetratricopeptide repeat; Region: TPR_12; pfam13424
272568009606	binding surface
272568009607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568009608	binding surface
272568009609	TPR repeat; Region: TPR_11; pfam13414
272568009610	TPR motif; other site
272568009611	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
272568009612	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568009613	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
272568009614	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568009615	catalytic residue [active]
272568009616	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
272568009617	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
272568009618	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
272568009619	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
272568009620	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
272568009621	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
272568009622	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
272568009623	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
272568009624	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
272568009625	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
272568009626	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
272568009627	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
272568009628	GatB domain; Region: GatB_Yqey; smart00845
272568009629	O-Antigen ligase; Region: Wzy_C; pfam04932
272568009630	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
272568009631	active site
272568009632	catalytic motif [active]
272568009633	Zn binding site [ion binding]; other site
272568009634	diaminopimelate decarboxylase; Region: lysA; TIGR01048
272568009635	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
272568009636	active site
272568009637	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
272568009638	substrate binding site [chemical binding]; other site
272568009639	catalytic residues [active]
272568009640	dimer interface [polypeptide binding]; other site
272568009641	TIGR02302 family protein; Region: aProt_lowcomp
272568009642	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
272568009643	argininosuccinate lyase; Provisional; Region: PRK00855
272568009644	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
272568009645	active sites [active]
272568009646	tetramer interface [polypeptide binding]; other site
272568009647	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
272568009648	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
272568009649	catalytic residues [active]
272568009650	N-formylglutamate amidohydrolase; Region: FGase; cl01522
272568009651	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
272568009652	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
272568009653	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
272568009654	shikimate binding site; other site
272568009655	NAD(P) binding site [chemical binding]; other site
272568009656	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
272568009657	dephospho-CoA kinase; Region: TIGR00152
272568009658	CoA-binding site [chemical binding]; other site
272568009659	ATP-binding [chemical binding]; other site
272568009660	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
272568009661	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
272568009662	active site
272568009663	catalytic site [active]
272568009664	substrate binding site [chemical binding]; other site
272568009665	Cache domain; Region: Cache_1; pfam02743
272568009666	cyclase homology domain; Region: CHD; cd07302
272568009667	nucleotidyl binding site; other site
272568009668	metal binding site [ion binding]; metal-binding site
272568009669	dimer interface [polypeptide binding]; other site
272568009670	Permease; Region: Permease; pfam02405
272568009671	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
272568009672	mce related protein; Region: MCE; pfam02470
272568009673	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
272568009674	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
272568009675	Sulfate transporter family; Region: Sulfate_transp; pfam00916
272568009676	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
272568009677	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
272568009678	active site
272568009679	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
272568009680	Ligand Binding Site [chemical binding]; other site
272568009681	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
272568009682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568009683	biotin synthase; Region: bioB; TIGR00433
272568009684	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568009685	FeS/SAM binding site; other site
272568009686	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
272568009687	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
272568009688	CoA binding domain; Region: CoA_binding; pfam02629
272568009689	CoA-ligase; Region: Ligase_CoA; pfam00549
272568009690	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
272568009691	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
272568009692	CoA-ligase; Region: Ligase_CoA; pfam00549
272568009693	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
272568009694	dinuclear metal binding motif [ion binding]; other site
272568009695	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
272568009696	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
272568009697	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
272568009698	active site
272568009699	Zn binding site [ion binding]; other site
272568009700	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
272568009701	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
272568009702	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
272568009703	putative active site [active]
272568009704	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
272568009705	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
272568009706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568009707	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
272568009708	NAD(P) binding site [chemical binding]; other site
272568009709	active site
272568009710	acyl carrier protein; Provisional; Region: acpP; PRK00982
272568009711	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
272568009712	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
272568009713	dimer interface [polypeptide binding]; other site
272568009714	active site
272568009715	YceG-like family; Region: YceG; pfam02618
272568009716	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
272568009717	dimerization interface [polypeptide binding]; other site
272568009718	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
272568009719	putative amphipathic alpha helix; other site
272568009720	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
272568009721	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
272568009722	active site
272568009723	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
272568009724	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
272568009725	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
272568009726	putative ADP-binding pocket [chemical binding]; other site
272568009727	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
272568009728	active site
272568009729	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
272568009730	Predicted permeases [General function prediction only]; Region: COG0795
272568009731	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
272568009732	Predicted permeases [General function prediction only]; Region: COG0795
272568009733	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
272568009734	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
272568009735	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
272568009736	active site
272568009737	metal binding site [ion binding]; metal-binding site
272568009738	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
272568009739	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
272568009740	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
272568009741	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
272568009742	catalytic residue [active]
272568009743	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
272568009744	acyl-CoA synthetase; Validated; Region: PRK09192
272568009745	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
272568009746	acyl-activating enzyme (AAE) consensus motif; other site
272568009747	active site
272568009748	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
272568009749	Uncharacterized conserved protein [Function unknown]; Region: COG3334
272568009750	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
272568009751	FHIPEP family; Region: FHIPEP; pfam00771
272568009752	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
272568009753	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568009754	TPR motif; other site
272568009755	binding surface
272568009756	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
272568009757	TPR repeat; Region: TPR_11; pfam13414
272568009758	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568009759	binding surface
272568009760	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
272568009761	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
272568009762	N-acetyl-D-glucosamine binding site [chemical binding]; other site
272568009763	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
272568009764	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
272568009765	Rod binding protein; Region: Rod-binding; pfam10135
272568009766	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
272568009767	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
272568009768	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
272568009769	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
272568009770	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
272568009771	flagellin; Reviewed; Region: PRK12687
272568009772	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
272568009773	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
272568009774	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
272568009775	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
272568009776	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
272568009777	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
272568009778	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
272568009779	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
272568009780	Cache domain; Region: Cache_1; pfam02743
272568009781	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
272568009782	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
272568009783	dimer interface [polypeptide binding]; other site
272568009784	putative CheW interface [polypeptide binding]; other site
272568009785	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
272568009786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568009787	active site
272568009788	phosphorylation site [posttranslational modification]
272568009789	intermolecular recognition site; other site
272568009790	dimerization interface [polypeptide binding]; other site
272568009791	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
272568009792	DNA binding site [nucleotide binding]
272568009793	Flagellar protein FlaF; Region: FlaF; cl11454
272568009794	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
272568009795	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
272568009796	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
272568009797	Walker A motif; other site
272568009798	ATP binding site [chemical binding]; other site
272568009799	Walker B motif; other site
272568009800	flagellar motor protein MotB; Validated; Region: motB; PRK09041
272568009801	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
272568009802	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
272568009803	ligand binding site [chemical binding]; other site
272568009804	flagellar motor protein MotA; Validated; Region: PRK09110
272568009805	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
272568009806	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
272568009807	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
272568009808	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
272568009809	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
272568009810	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
272568009811	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
272568009812	FliG C-terminal domain; Region: FliG_C; pfam01706
272568009813	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
272568009814	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
272568009815	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
272568009816	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
272568009817	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
272568009818	dimer interface [polypeptide binding]; other site
272568009819	putative CheW interface [polypeptide binding]; other site
272568009820	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366
272568009821	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
272568009822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568009823	active site
272568009824	phosphorylation site [posttranslational modification]
272568009825	intermolecular recognition site; other site
272568009826	dimerization interface [polypeptide binding]; other site
272568009827	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
272568009828	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
272568009829	putative binding surface; other site
272568009830	active site
272568009831	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
272568009832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568009833	ATP binding site [chemical binding]; other site
272568009834	Mg2+ binding site [ion binding]; other site
272568009835	G-X-G motif; other site
272568009836	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
272568009837	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
272568009838	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
272568009839	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
272568009840	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
272568009841	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
272568009842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568009843	active site
272568009844	phosphorylation site [posttranslational modification]
272568009845	intermolecular recognition site; other site
272568009846	dimerization interface [polypeptide binding]; other site
272568009847	CheB methylesterase; Region: CheB_methylest; pfam01339
272568009848	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
272568009849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568009850	active site
272568009851	phosphorylation site [posttranslational modification]
272568009852	intermolecular recognition site; other site
272568009853	dimerization interface [polypeptide binding]; other site
272568009854	CheD chemotactic sensory transduction; Region: CheD; cl00810
272568009855	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
272568009856	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788
272568009857	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786
272568009858	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
272568009859	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
272568009860	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
272568009861	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
272568009862	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
272568009863	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
272568009864	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
272568009865	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
272568009866	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
272568009867	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
272568009868	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913
272568009869	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
272568009870	flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795
272568009871	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
272568009872	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
272568009873	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
272568009874	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
272568009875	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
272568009876	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
272568009877	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
272568009878	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
272568009879	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
272568009880	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
272568009881	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
272568009882	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
272568009883	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
272568009884	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
272568009885	ATP binding site [chemical binding]; other site
272568009886	Walker A motif; other site
272568009887	hexamer interface [polypeptide binding]; other site
272568009888	Walker B motif; other site
272568009889	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
272568009890	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
272568009891	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
272568009892	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
272568009893	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
272568009894	TPR motif; other site
272568009895	TPR repeat; Region: TPR_11; pfam13414
272568009896	binding surface
272568009897	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
272568009898	TadE-like protein; Region: TadE; pfam07811
272568009899	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
272568009900	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
272568009901	hypothetical protein; Provisional; Region: PRK07208
272568009902	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
272568009903	UDP-galactopyranose mutase; Region: GLF; pfam03275
272568009904	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
272568009905	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
272568009906	active site
272568009907	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
272568009908	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
272568009909	E3 interaction surface; other site
272568009910	lipoyl attachment site [posttranslational modification]; other site
272568009911	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
272568009912	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
272568009913	catalytic site [active]
272568009914	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
272568009915	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
272568009916	alpha subunit interface [polypeptide binding]; other site
272568009917	TPP binding site [chemical binding]; other site
272568009918	heterodimer interface [polypeptide binding]; other site
272568009919	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
272568009920	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
272568009921	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
272568009922	tetramer interface [polypeptide binding]; other site
272568009923	TPP-binding site [chemical binding]; other site
272568009924	heterodimer interface [polypeptide binding]; other site
272568009925	phosphorylation loop region [posttranslational modification]
272568009926	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
272568009927	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
272568009928	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
272568009929	ATP-grasp domain; Region: ATP-grasp; pfam02222
272568009930	AIR carboxylase; Region: AIRC; pfam00731
272568009931	Protein of unknown function (DUF465); Region: DUF465; pfam04325
272568009932	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
272568009933	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
272568009934	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
272568009935	putative dimer interface [polypeptide binding]; other site
272568009936	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
272568009937	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
272568009938	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
272568009939	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
272568009940	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
272568009941	active site
272568009942	putative substrate binding pocket [chemical binding]; other site
272568009943	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
272568009944	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568009945	NAD(P) binding site [chemical binding]; other site
272568009946	active site
272568009947	Radical SAM superfamily; Region: Radical_SAM; pfam04055
272568009948	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
272568009949	FeS/SAM binding site; other site
272568009950	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
272568009951	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
272568009952	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
272568009953	aromatic arch; other site
272568009954	DCoH dimer interaction site [polypeptide binding]; other site
272568009955	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
272568009956	DCoH tetramer interaction site [polypeptide binding]; other site
272568009957	substrate binding site [chemical binding]; other site
272568009958	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568009959	ABC transporter ATPase component; Reviewed; Region: PRK11147
272568009960	ABC transporter; Region: ABC_tran_2; pfam12848
272568009961	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
272568009962	two-component response regulator; Provisional; Region: PRK09191
272568009963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
272568009964	active site
272568009965	phosphorylation site [posttranslational modification]
272568009966	intermolecular recognition site; other site
272568009967	dimerization interface [polypeptide binding]; other site
272568009968	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
272568009969	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
272568009970	RNA polymerase sigma factor; Provisional; Region: PRK12547
272568009971	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
272568009972	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
272568009973	DNA binding residues [nucleotide binding]
272568009974	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
272568009975	Histidine kinase; Region: HisKA_2; pfam07568
272568009976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
272568009977	ATP binding site [chemical binding]; other site
272568009978	Mg2+ binding site [ion binding]; other site
272568009979	G-X-G motif; other site
272568009980	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
272568009981	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568009982	Walker A/P-loop; other site
272568009983	ATP binding site [chemical binding]; other site
272568009984	Q-loop/lid; other site
272568009985	ABC transporter signature motif; other site
272568009986	Walker B; other site
272568009987	D-loop; other site
272568009988	H-loop/switch region; other site
272568009989	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
272568009990	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
272568009991	Walker A/P-loop; other site
272568009992	ATP binding site [chemical binding]; other site
272568009993	Q-loop/lid; other site
272568009994	ABC transporter signature motif; other site
272568009995	Walker B; other site
272568009996	D-loop; other site
272568009997	H-loop/switch region; other site
272568009998	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
272568009999	ligand binding site [chemical binding]; other site
272568010000	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
272568010001	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
272568010002	ATP binding site [chemical binding]; other site
272568010003	putative Mg++ binding site [ion binding]; other site
272568010004	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
272568010005	nucleotide binding region [chemical binding]; other site
272568010006	ATP-binding site [chemical binding]; other site
272568010007	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
272568010008	HRDC domain; Region: HRDC; pfam00570
272568010009	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
272568010010	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
272568010011	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
272568010012	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
272568010013	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
272568010014	amphipathic channel; other site
272568010015	Asn-Pro-Ala signature motifs; other site
272568010016	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
272568010017	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
272568010018	N- and C-terminal domain interface [polypeptide binding]; other site
272568010019	active site
272568010020	MgATP binding site [chemical binding]; other site
272568010021	catalytic site [active]
272568010022	metal binding site [ion binding]; metal-binding site
272568010023	glycerol binding site [chemical binding]; other site
272568010024	homotetramer interface [polypeptide binding]; other site
272568010025	homodimer interface [polypeptide binding]; other site
272568010026	FBP binding site [chemical binding]; other site
272568010027	protein IIAGlc interface [polypeptide binding]; other site
272568010028	Protein of unknown function (DUF461); Region: DUF461; pfam04314
272568010029	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
272568010030	ATP cone domain; Region: ATP-cone; pfam03477
272568010031	transcription antitermination factor NusB; Region: nusB; TIGR01951
272568010032	putative RNA binding site [nucleotide binding]; other site
272568010033	thiamine monophosphate kinase; Provisional; Region: PRK05731
272568010034	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
272568010035	ATP binding site [chemical binding]; other site
272568010036	dimerization interface [polypeptide binding]; other site
272568010037	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
272568010038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
272568010039	NAD(P) binding site [chemical binding]; other site
272568010040	active site
272568010041	glucokinase, proteobacterial type; Region: glk; TIGR00749
272568010042	Glucokinase; Region: Glucokinase; pfam02685
272568010043	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
272568010044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
272568010045	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
272568010046	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
272568010047	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
272568010048	active site
272568010049	HIGH motif; other site
272568010050	nucleotide binding site [chemical binding]; other site
272568010051	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
272568010052	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
272568010053	active site
272568010054	KMSKS motif; other site
272568010055	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
272568010056	tRNA binding surface [nucleotide binding]; other site
272568010057	anticodon binding site; other site
272568010058	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
272568010059	methionine sulfoxide reductase A; Provisional; Region: PRK14054
272568010060	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
272568010061	Walker A/P-loop; other site
272568010062	ATP binding site [chemical binding]; other site
272568010063	ABC transporter; Region: ABC_tran; pfam00005
272568010064	Q-loop/lid; other site
272568010065	ABC transporter signature motif; other site
272568010066	Walker B; other site
272568010067	D-loop; other site
272568010068	H-loop/switch region; other site
272568010069	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
272568010070	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
272568010071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568010072	dimer interface [polypeptide binding]; other site
272568010073	conserved gate region; other site
272568010074	putative PBP binding loops; other site
272568010075	ABC-ATPase subunit interface; other site
272568010076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
272568010077	dimer interface [polypeptide binding]; other site
272568010078	conserved gate region; other site
272568010079	ABC-ATPase subunit interface; other site
272568010080	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
272568010081	trimer interface [polypeptide binding]; other site
272568010082	active site
272568010083	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
272568010084	Flavoprotein; Region: Flavoprotein; pfam02441
272568010085	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
272568010086	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
272568010087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
272568010088	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
272568010089	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
272568010090	DNA binding site [nucleotide binding]
272568010091	catalytic residue [active]
272568010092	H2TH interface [polypeptide binding]; other site
272568010093	putative catalytic residues [active]
272568010094	turnover-facilitating residue; other site
272568010095	intercalation triad [nucleotide binding]; other site
272568010096	8OG recognition residue [nucleotide binding]; other site
272568010097	putative reading head residues; other site
272568010098	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
272568010099	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
272568010100	Initiator Replication protein; Region: Rep_3; pfam01051
272568010101	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
272568010102	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
272568010103	Magnesium ion binding site [ion binding]; other site
272568010104	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
272568010105	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
272568010106	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
272568010107	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
272568010108	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
272568010109	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
272568010110	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568010111	Sel1-like repeats; Region: SEL1; smart00671
272568010112	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
272568010113	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
272568010114	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
272568010115	HlyD family secretion protein; Region: HlyD_3; pfam13437
272568010116	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
272568010117	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
272568010118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
272568010119	Walker A/P-loop; other site
272568010120	ATP binding site [chemical binding]; other site
272568010121	Q-loop/lid; other site
272568010122	ABC transporter signature motif; other site
272568010123	Walker B; other site
272568010124	D-loop; other site
272568010125	H-loop/switch region; other site
272568010126	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
272568010127	oligomeric interface; other site
272568010128	putative active site [active]
272568010129	homodimer interface [polypeptide binding]; other site
272568010130	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
272568010131	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
272568010132	MobA/MobL family; Region: MobA_MobL; pfam03389
272568010133	AAA domain; Region: AAA_30; pfam13604
272568010134	Conjugal transfer protein TraD; Region: TraD; pfam06412
272568010135	Conjugal transfer protein TraD; Region: TraD; pfam06412
272568010136	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
272568010137	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
272568010138	oligomeric interface; other site
272568010139	putative active site [active]
272568010140	homodimer interface [polypeptide binding]; other site
272568010141	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
272568010142	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
272568010143	active site
272568010144	metal binding site [ion binding]; metal-binding site
272568010145	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
272568010146	Predicted transcriptional regulator [Transcription]; Region: COG2944